LOCUS       gnlProkkaBNKOPIDN_172  15368 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BNKOPIDN_172.
ACCESSION   gnlProkkaBNKOPIDN_172
VERSION     gnlProkkaBNKOPIDN_172
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:31:13
            Original ID  :: gnl|Prokka|BNKOPIDN_172
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15368
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3934:7072]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3935..7072
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..15368
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15368
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             3..395
                     /locus_tag="ctg164_1"
                     /transl_table=11
                     /translation="MARDLSFDWLGDARERFQVGEHILVRILAIQGDSPETLSIHADVK
                     SVEGNTSKENLKNCRVQGKYAGTVEDIHKGTVFVRLELGVNAIAHSCYDSRTVGKKDKV
                     SFVVTHIDEERNVAVGIITRIIKQNI"
     CDS             complement(1076..1741)
                     /locus_tag="ctg164_2"
                     /transl_table=11
                     /translation="MKKKEIVIGVSVLISASLPISVYAASNESMSSRGFIIDETNEFED
                     IVKQILDVKSKHPEWSEQQISDFMDQIHAIKKDGVIDIWNALTSSEKKLVIRYPFDALK
                     VNKAKEIATKQTERKFGKNGLGDRSDAFRHGIWNAEMTVLIGSEKAELFATAHEDKDTT
                     GNESDGYTKDEHKKMDLHNNEIGRKLGADNLSAPEEKMAEIIYDEIMREDSLFVWLHE"
     CDS             complement(1796..3892)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 257.4; E-value:
                     4.6e-78)"
                     /gene_kind="transport"
                     /locus_tag="ctg164_3"
                     /sec_met_domain="Peptidase_C39 (E-value: 4.2e-31, bitscore:
                     97.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKKVHYVSQLGSMDCGIACLTMILNYYGCKSDIVDIGAEIQIG
                     RDGMTLAQMKELAEKYGFKFAAYQYNHEEKNLIEYLPAILCNDSHYVVVDKTKKKGKYI
                     LFDPANGKRVVDFLELKNGYKDILVSVIPSRNIKKIKKTKFKIEVKFSQFMIAIMLMLM
                     CQLITLAVPMVVQKVIDSLSSAHITIHIWKITLLVLLIMCAHFVLSLLRQKILLNINMK
                     LFKTMISNMIHKIFRLDVSFFEWHSAGDIGNRFNSINQLNDILTNGFINIIIQGITSLV
                     CLAVMTSISPYLTAFVLVVSIIQIAIMILLNGKNLIKTKEYIYSQSTIQGELIDTLENI
                     MEIKCMGMDNAVKSNLQNSYSKLIERFKGKTRISNLMNSFSSTLNLIFPLMIYVIGSYS
                     VKQGGLTIGQLIAYATLVGYFTAPFTTVVLLLPSINSIKEVLLRYKELMIFRENYHTGV
                     LVPGKFENLKISSVSYCYNSGQAYALNNVSLDLRRGERIAIVGLSGSGKSTLIKAILGA
                     VDINQGCIEINNYDIRSMSKEQIYKWFSVVTQNPMCLNASIRKNIDIIGDAPDEKIWKV
                     LDIVALKEEVLSMPLGLDTLVGEGGQNISGGQKQRIAIARALLSDTEVVIFDEATSNLD
                     QLTEKKIYDNLRSTNKTQIIITHRLSSIRDTDYIYVLNRGSIIEQGTHLDLMKKKGWYF
                     ESIQ"
     CDS             complement(3935..7072)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     852.5; E-value: 7.4e-258)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg164_4"
                     /sec_met_domain="DUF4135 (E-value: 1.2e-104, bitscore:
                     340.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.8e-58, bitscore:
                     187.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNNCDNNSYFYERNYYKDVPIKDTQILEYWNNILGKDVIESID
                     KAYGVSIEQILFSEYSLNHKYISFATLNQEYSDMCNEKAISYLTKKGTKVLFDQFVLRF
                     LGYGKRVLERKSRKGYIVKVIQDCFLKNLAERILDVSLSTLIFEMYLAKEQGELRGNDE
                     AEEYNDYNQRFLGNDKYIKELFSIYPGLKRMLIELMENLANNYILLQERMEKDTLLLED
                     KFGGKKSWTEVKDIRTSGSDSHKKGNSVFLIQFQDGTKIVYKPHGLKVEKAYQSFLEFI
                     SSNCKKDFRQFLILDCGDYGWEEFVVNLPCNSEAEVRNYYYRIGVLVFCNYILNVNDIH
                     TENLIANGGYPVVVDAETVLDNKRDKKKKSGREKIYDKIHESVLYSGVLPFYKYTKNGK
                     GINMSALNGQEGEQYPILIPRLKNAGTSNMHYEYERPITQASNNLLRLGEKVKEPNQYI
                     DEICEGFFDAYTFCLDNKKLILNYVSIFENIEVRHLVQDTQRYSMLLHTSYNPDFLQDA
                     KDRQLFLCAVLKNVEQMQGNMEIAKLEIKDMLNMDIPYFYSNTSKEDLYGSEGEVVKNY
                     FAESSIQHLRNKICSMGKKDREEQIRFIKIILTDLNDVKVEKPKKDINELCISRSDNEH
                     GQKEYKKNAILKILHTLEQKAFYGDDGQDINWIGITSIGNSENSSWNIQPLGVYLYEGL
                     GGIALFYNALQQSDFDVDLSAACKAFETMMFQYTDDMLERSTDLEKESSGAYAGEASVI
                     YVYEVLYKITGKQKYLEYAEKHCKILEYALKADENNDLIYGNAGAVIVLLNLYHLAQKD
                     IYLQLACEAGNILIKNQNKGKWCCGNGQSLSGLSHGITGIIYALTKLNNEQFHIEYQKA
                     IHSGLIYENTMYSDKYNNWLDNREEAKKEENSDNRCMAAWCHGAPGILLARSKMYNLVK
                     DSSDYITVQCDIERALFATKMYGFTDNDCLCHGNLGNTEILLEYSKECNDEEVRHMMLS
                     ARTQIAMDIINENYDCARSYLHGYKIPGFMTGISGMGYSLLRDLYPELPCILALEI"
     CDS             complement(7189..7389)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg164_5"
                     /transl_table=11
                     /translation="MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSD
                     GSQFCTSTKECNWGTIMFVCC"
     CDS_motif       complement(7249..7389)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS"
                     /locus_tag="ctg164_5_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7189..7248)
                     /prepeptide="core"
                     /locus_tag="ctg164_5_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="2129.5"
                     /monoisotopic_mass="2127.9"
                     /core_sequence="QFCTSTKECNWGTIMFVCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEP
                     RVSDGS"
                     /leader_location="[7248:7389](-)"
     CDS             complement(7664..8449)
                     /locus_tag="ctg164_6"
                     /transl_table=11
                     /translation="MGNIISTELLKIKRYSVVKAGLVMMSLSVLMSCFYSIASTNKVWD
                     FQYFIQQVIISNCTLFFPIIITLVAVYIISRETTDDTLKSILTVPISYKKLLIAKFWLL
                     LFLTIVFSIFNALLSICFNAFLGFSGMNIHMMLMSAAQIIVSDILVYISVLPIIIVCAF
                     AEGKSLLGVAVAFIYGYFATMEGSMLNWFPIKAAMILVDPKCGSEYGITYKIPPAAMSI
                     IGVLVVSILLFQMLNRTKKNVYMKSKRKVKVKQTRRKGW"
     CDS             complement(8455..9264)
                     /locus_tag="ctg164_7"
                     /transl_table=11
                     /translation="MLDLVRCEFTKLKRRKITLMLIVLSCFFPLIVVMTTKNGMSGDLS
                     THYLKMRFDLSFTMTQGYGLVFLAPCLIGMLATILFFMERDNDTFKNIRTVPVTITKMI
                     LAKICVLFIYGTLFSLASVSFTIFFSWILKVGIIYDLAYKLGFSIIFGLVITIASLPIV
                     VIIVYFNKSYLVSTLLAFFYSILNWGIIGLFETMAVKGTAKFLNLFPVICAMDWTSGKL
                     VDHVIKDNLSKEAYIMFPSDIYAFLVLGVTLFLSLMLMIRFYKKWTR"
     CDS             complement(9257..10180)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 179.5; E-value:
                     1.4e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg164_8"
                     /transl_table=11
                     /translation="MSQYIIQTRDLTKTYGEQKSVSNLNMHVRKGKIYGLLGRNGAGKT
                     TTMKMLLNLIEPTSGSIRIFNRDIRLEEKKILPRIGSLIESPGFYPNLTGTENLRIFAK
                     LRGIPRTDAIEQALKLVNLPYKDKKLYSQYSLGMKQRLAIALAVMHDPEILILDEPING
                     LDPIGIAEIRTFIEDLSKNRGKTILISSHILSEIAVLADDIGIIDKGVLIEEGSMKELE
                     EKNGKYIHFKVSDNAQAARILSVYYKESNFKVSGNQDINVYNLSISIPDIVRSFVQEGV
                     DVMDAHLCEDTLEDYFKKVTGGEGIA"
     CDS             complement(10213..10311)
                     /gene="allorf_10213_10311"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_10213_10311"
                     /protein_id="allorf_10213_10311"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIRSSIIFFVLNKLQGSCQVSVRFLSEKYIIL"
     CDS_motif       complement(10261..10311)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MIRSSIIFFVLNKLQGS"
                     /locus_tag="allorf_10213_10311_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(10213..10260)
                     /prepeptide="core"
                     /locus_tag="allorf_10213_10311_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="1762.1"
                     /monoisotopic_mass="1761.0"
                     /core_sequence="CQVSVRFLSEKYIIL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIRSSIIFFVLNKLQGS"
                     /leader_location="[10260:10311](-)"
                     /alternative_weights="1780.1"
     CDS             complement(10320..11237)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 150.3; E-value: 1.7e-45)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg164_9"
                     /transl_table=11
                     /translation="MKLFYVVLVILLFYNLGLTLYVFKINRRLKEFNQILLEIEKGQSK
                     QKFLLKKNNRIDQVGFRVNSILYKYEKRIEESNIELEANKQLMTSLSHDVRTPMTTLIG
                     YLDALDLKLVSSDKEEQYLRLAKEKAYDLKKYIEVLFEWFRINSDEEQLEIKAVDITEE
                     TRRIFLDWIPIIEEHRIGYNIEIPEKAIIVEIDEDCYMRAINNIVQNIFTHSKAANISI
                     TASEGNGKFRLEIGDDGIGIAKEDLNYIFERLYRCNKGRSGKGNGLGLNISKLLLEKMG
                     GTISAFSEPGKGTVFCIEFSVIQR"
     CDS             complement(11243..11932)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 193.2; E-value: 7.7e-59)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg164_10"
                     /transl_table=11
                     /translation="MRKDIIIIDDDRDLCTLLQESLLQENICADISCNGFDGIKSVKDK
                     EYQLVVLDVMMPGISGFEVLERIRDMSNVPILMLTAKDDSTSKVKGLRAGADDYLTKPF
                     EMEEFFARVLSLIRRYTRLNNMASKAILKYGDLRIDLESGIVELSGEELKLSAKEYDVL
                     IYLAKNQGKILTKKQIYENVWNEEYVYDDDNIMAVISRLRKKIERTAENSYIQTVRGLG
                     YRFNKEL"
     CDS             complement(12681..15089)
                     /locus_tag="ctg164_11"
                     /transl_table=11
                     /translation="MGFFVNLYRIEVGKMKGNNEKKVIGHLARQDLNSVRLKKFCGILT
                     IILSTALIIVVTLYFVQTQRFSIQDAEGRYQATFMDVNSKVVNKMKAMKNVEMGETRTL
                     GTLNQGTYKITIRTMTESLLKLGRYPELKGKLPEMEKEVVVTDSYLEEVQSKAKIGDSI
                     EIDLGDGKESYVIAGILPMQSTADTHSIYVSDKLIERKMPGALYSIYFKINDTQGWNEA
                     GIKSEIDKIAQQLDVPKDSIVYSSYYFSLISQKSIQYISVILGVSLVIAIISSIVIYSI
                     FFVSVLERIGKYGQMRTLGMTKKQIRKIIKIEGNVLTLKGCFWGCVFGGIIAYFIQPKG
                     WYLVNTILISGMASAFVYFVVMLSLYKPAKIASAASPIEALRYFADTEVNINRKHSYKK
                     ITLWRLALLSVQRNKKKTFLTILSLGICGIVLMASSSYLNSIDPYNMAKKSMPNGEIKI
                     ELGTYGPQSYTSKQYFDLQKNNILNQELLKKLEDMQAVESIKQYKGTVCDITLPNGDTD
                     IFVVDGIQSGDITNLKKFLVDGEIDFKKMQQKNGIVVSEASEWETLWDWEVKIGDTINI
                     LDSEGVPVKYEVVGIVENGADYGGYNMVYMPLSNMEELRKDVLNLTYQLSIKTTSDTNV
                     SKTEDMIRKMFQNEMPIQFTTIDDVAASYKQRIDAYRKPVYGLVIFVGIFGIVNLLNML
                     FSNMATRKREYGMLQCVGLTDKQLSSIVVKEGILYSVGSISISLIFGTIFGIILCNVFS
                     SFSVFGKVIYHFPFKEMTVYFSILIIVQMIFAYIIINFYKRESLIDRIK"
     CDS             complement(15138..15368)
                     /locus_tag="ctg164_12"
                     /transl_table=11
                     /translation="MYGHLRRYKKIVKKTYIILYKFLMKGGVKMLEHKENKELTEAEVN
                     AYDLVIICYGKLRKDCLTDCLDGTYWLSPEQ"
ORIGIN
        1 tccttgcaag agatctgtct tttgactggc tgggtgatgc cagggaacga ttccaggtag
       61 gggaacatat tctggtccgg atcttagcta tccagggaga ttccccggaa acgctctcta
      121 tccatgcaga tgtaaaaagc gtggaaggca acaccagcaa agaaaatctg aaaaattgtc
      181 gggtacaagg aaaatatgcc ggtacggtgg aagacatcca caaaggaact gtttttgtcc
      241 ggttagaatt gggtgtcaac gccattgctc acagttgcta cgacagccgc accgttggga
      301 agaaagataa ggtgtccttt gttgtgacac atattgatga agaacggaat gttgctgttg
      361 gcatcattac aaggattatc aaacaaaata tctgattacc aaaagcaata tgaaaaggag
      421 ctcactacat ccatttctta ttgcgataca agatattcca tgctatactg agcgagtata
      481 gctaatcgag aaagagatgc ggatgcaatt tcgaccagcc ctctagtttt taaaggaggg
      541 tgatgcccat gaacacaatg gaagtactca cattgctttt agtagttttt gcggctctga
      601 cttacataga taatcgacat gataagaaat agcatccacg ataaaccctg agaaagtttg
      661 atggatgcta tgtcttaaca tagaaaaaaa ttaaatttta ctgagggcat cagatcttgc
      721 atctgattac ctttcttaat tagattatac actgggggat atgagaaatc aagtccccct
      781 ttattattgt tattgtcatt acttaaacta aatcgacaaa taatatgttg ataaatattt
      841 ttctacagcc ccctcattct catttgacca tcatttaaca gatttcacat ctaattcatg
      901 gctatacatt agtacttggt tctcattctg attcttcttt caaatttagt cagagcagac
      961 atttttaacg actattattt ctattcaaaa acagtcacag atatctaaac atcaataaaa
     1021 tatctgcgac tgtcttagag atatatttca tttcagttca tacgttctaa ctttttcatt
     1081 catgcagcca tacaaacagc gaatcttctc tcattatctc gtcatatatg atttccgcca
     1141 ttttctcttc tggtgcagat aggttatctg cacctaattt cctccctatt tcattgttat
     1201 gtaaatccat ttttttgtgc tcatcttttg tatatccatc gctttcgttt ccagtagtat
     1261 ctttatcttc atgtgctgtc gcaaaaagct ctgctttttc acttcctatc aaaactgtca
     1321 tttcggcatt ccatattccg tgtctaaatg cgtcactcct gtcacccaaa ccattttttc
     1381 cgaattttct ttcggtttgt ttagtggcaa tttcctttgc tttattgact tttagtgcat
     1441 caaacggata tcgaatcact aattttttct cagaagaagt aagtgcgttc caaatgtcta
     1501 tgacgccatc tttcttaata gcatgaatct gatccataaa atcacttatc tgctgttcac
     1561 tccattccgg atgttttgac ttaacatcta aaatttgctt aacgatatcc tcaaactcat
     1621 tagtttcatc aattataaaa cctctagaac tcatactttc atttgaagca gcataaactg
     1681 aaatgggaag tgatgcacta atcagtacgc tcaccccaat aactatctct ttcttcttca
     1741 tctgtaatac ctccccatac aatggctttt catatcataa tttaattcct atctgtcatt
     1801 gaatactctc aaaataccat ccctttttct tcatcaaatc caaatgtgtt ccctgttcaa
     1861 tgatgcttcc cctgttcaat acatagatat aatccgtatc tcgaatagag gaaagtctat
     1921 gagtaatgat aatttgcgtt ttattggtag accttaggtt atcataaatt ttcttttctg
     1981 taagctgatc cagattactg gtagcttcat caaaaataac tacctccgta tcgctaagca
     2041 gagctcttgc tatggcaata cgctgttttt gaccacctga aatattttgt cctccttctc
     2101 caacaagtgt atccaatccc aacggcatac ttaaaacttc ctcttttaat gctacaatgt
     2161 ctagtacctt ccatattttc tcatccggag catcacctat aatatcaata ttctttctta
     2221 tacttgcatt taagcacata ggattttgag taactactga aaaccattta taaatctgtt
     2281 ccttcgacat tgatctgata tcataattat ttatctcaat acatccttga ttaatatcca
     2341 cggcacccag tatggctttt atcaaggttg attttccact acccgataaa ccaacaatag
     2401 caattctctc gcctcgccta agatcaagag aaacattatt caatgcgtat gcctgcccac
     2461 tattgtagca atatgaaacc gaacttattt ttaaattttc aaattttcca ggtacaagaa
     2521 ctcccgtatg ataattttct ctaaaaatca ttagttcctt ataacgtaaa agcacttctt
     2581 taatactatt gatactcggt aacaacaata caacggtagt aaaaggtgct gtaaaatatc
     2641 ccactaaggt tgcataggct ataagttgtc ctatcgttaa ccctccttgc ttcacactat
     2701 aacttccaat cacgtaaatc attaaaggga aaatcaagtt taaggttgag gaaaaactat
     2761 tcatcaaatt actaattcga gtttttccct tgaatctttc tattaactta ctataagaat
     2821 tttgtaaatt tgatttaact gcattatcca tccccataca ttttatttcc attatattct
     2881 ccagagtatc tatcagttct ccctgtattg tactctgtga gtatatatac tctttcgtct
     2941 ttatgagatt tttaccattt aataaaatca ttatggcgat ctgtataata gaaacaacta
     3001 gaacaaatgc agtcaaatat ggagatatac tggtcataac agctaaacat accaaggatg
     3061 taatcccttg gattataatg tttataaatc cattggtaag aatgtcgttc aactgattta
     3121 tactattgaa acggttccct atgtcacctg cggaatgcca ttcaaaaaaa cttacatcca
     3181 aacggaaaat tttatgaatc atattagaaa tcattgtttt aaaaagtttc atgttaatat
     3241 tcaataaaat tttctgtctt agtaagctca atacaaaatg ggcacacata atcagaagaa
     3301 ctaaaagtgt aattttccat atatgaattg taatatgggc agaagataaa ctatctatta
     3361 ctttttgcac aaccattgga acagctaatg taataagttg acacataagc atcaacataa
     3421 ttgcaatcat aaattgagag aattttacct ctattttaaa tttggttttt tttattttct
     3481 taatatttct acttggaata acggatacaa gaatatcctt gtatccgttt tttaattcta
     3541 aaaaatcgac aactcttttt ccatttgctg gatcaaacag aatatatttt cctttcttct
     3601 tagttttatc aactaccaca tagtgggaat cattacacaa aatggctgga agatactcta
     3661 ttaagttttt ttcttcatga ttatactggt atgcagcaaa tttaaatcca tacttttctg
     3721 ctaattcttt catttgagct aaggtcatac cgtctctgcc aatctgaatc tctgccccta
     3781 tgtccacgat atcactttta cacccgtaat aattaagaat cattgtcaga catgctatgc
     3841 cacaatccat gcttcctagc tgtgaaacat aatgcacttt tttttgaaac atcaagttcc
     3901 tccctttgtt aaatattact tagcaattac gctcctaaat ctccagagcc aaaatgcatg
     3961 gtaattctgg gtacaaatct cttaatagag agtatcccat tcctgagatt cctgtcataa
     4021 atcctggtat cttataccca tgcaaataag accttgcaca atcgtaattt tcatttataa
     4081 tatccatagc aatttgtgtt ctcgcagaca acatcatatg tcttacttct tcatcattac
     4141 attcttttga atattcaagt aatatttctg tattccccaa attcccatga catagacagt
     4201 cattatctgt aaatccatac atttttgtcg caaatagtgc acgttcaata tcacattgta
     4261 ctgttatata atcactactg tctttaacca ggttatacat cttacttctt gccaataaaa
     4321 tccctggtgc cccatgacac catgctgcca tgcatctatt atcagagttt tcttcttttt
     4381 ttgcctcctc ccgattgtct aaccaattat tatatttatc agaatacatg gtattttcat
     4441 atattaatcc agagtgtatt gccttttgat attcaatatg aaattgctca ttatttaact
     4501 ttgtaagagc ataaattata cctgtaattc catgtgacag cccagataag ctctgcccgt
     4561 ttccgcagca ccacttaccc ttattctgat tttttataag aatgttccct gcttcgcacg
     4621 ccaattgcaa atatatatcc ttttgagcta agtgataaag attaagaaga acaataacgg
     4681 cacctgcatt accataaatc agatcattat tttcatctgc tttcaatgca tactctaaaa
     4741 ttttgcaatg tttttctgca tattctaaat atttttgttt tcctgttatc ttatataaaa
     4801 cttcgtatac atatataaca gaagcttccc ccgcataagc accgctactt tccttttcta
     4861 aatccgtgga tcgttccaac atatcatcgg tatattgaaa catcatggtc tcaaatgctt
     4921 tgcaggctgc tgacaaatcc acatcaaaat ctgattgctg tagtgcatta taaaaaaggg
     4981 caattcctcc taatccttca tataaataaa cccctaatgg ttggatattc caagaagaat
     5041 tttcagaatt tccaatagat gttattccta tccaatttat atcctgccca tcatcaccat
     5101 aaaaagcttt ttgctctaat gtatgtaaaa tttttaatat ggcatttttt ttatattcct
     5161 tttgtccatg ttcattatcg cttctactta tacaaagttc atttatatct tttttaggtt
     5221 tctcaacttt tacatcattc aaatctgtta aaattatttt tataaatcta atctgttctt
     5281 ctctatcttt cttgcccata gaacagatct tatttctaag atgttgaata ctagactcag
     5341 caaaatagtt cttcaccact tccccttctg atccataaag atcttctttt gaagtattgc
     5401 tataaaaata tggaatatcc atattcagca tatcctttat ttccagtttt gcaatttcca
     5461 tattcccttg catctgttcc acatttttta acactgcaca caaaaatagt tgcctatctt
     5521 tcgcatcttg aagaaaatcc ggattgtatg atgtgtgcaa tagcatggaa taccgctgag
     5581 tatcttggac taaatgccta acttcaatat tttcaaatat cgaaacatag tttaatataa
     5641 gcttcttatt gtccaaacaa aatgtatatg cgtcaaaaaa accttcgcat atctcatcta
     5701 tatactgatt aggttctttt accttttccc ccagtctcag taaattatta ctagcttgag
     5761 taataggtct ttcatattca taatgcatat ttgatgtccc agcatttttt aatcttggaa
     5821 tcagtattgg atattgctct ccctcttggc cattaagagc actcatattt ataccttttc
     5881 catttttagt gtatttataa aaaggcagta ctccagaata caacactgat tcatgtatct
     5941 tatcgtaaat tttttctcta cctgattttt tctttttgtc ccttttatta tctaagacag
     6001 tctcggcatc tacaacaacc ggatatcccc cattagcaat aagattttca gtatgtatat
     6061 cattgacatt taatatataa ttgcaaaaaa caagcactcc tatccgataa taataattcc
     6121 tgacttcagc ctcactgtta caaggaagat taactacaaa ttcttcccat ccatagtccc
     6181 cacaatccag aatcaaaaat tgcctaaagt cctttttaca attggaagaa ataaattcca
     6241 aaaatgactg atatgctttc tccaccttca gtccgtgtgg tttataaact atttttgttc
     6301 catcttgaaa ctgaattaaa aaaacactat ttcctttctt atgtgaatct gaaccactcg
     6361 ttcttatatc ttttacttca gtccagctct ttttcccacc aaatttatct tctaaaagta
     6421 aagtatcctt ttccattctt tcctgcaata atatataatt atttgccaaa ttttccatta
     6481 attctatcag cattctttta agacctggat atatggaaaa taattctttt atatacttat
     6541 cattaccaag aaatctctga ttatagtcgt tatattcttc tgcttcatca tttcctctaa
     6601 gttctccttg ttcttttgct aaatacattt caaaaataag agtgcttaaa gaaacatcta
     6661 aaatcctttc cgctaaattt ttcaaaaaac agtcctgaat tactttaaca atatatcctt
     6721 ttctactctt tctttctaaa acccgtttcc catatcccag aaacctgaga acaaattgat
     6781 caaataatac ttttgtccct tttttagtca aataggatat agccttctca ttacacatat
     6841 cagaatattc ctgatttaac gttgcaaagc taatatattt atgatttaac gaatactctg
     6901 aaaataatat ctgctctata gaaaccccat aagccttatc tattgattca ataacatctt
     6961 tacctaaaat gttattccaa tattctaata tttgagtatc tttgattgga acatccttat
     7021 aataatttct ttcataaaaa taggaattat tgtcacaatt atttttatcc ataataatct
     7081 cctccattat gtaaaaaatt ttgaatttgc atatgatatc tatgcataga agccaaacct
     7141 attcattcag tagtcatcat acctgtggtt tcataccact ctcataaact aacagcaaac
     7201 aaacataatt gttccccagt tacattcttt tgttgatgta cagaactgag acccatcgga
     7261 aactcttggt tcaccagcac ctgcggaaaa attgtttaaa tccgcctctt taatttcctt
     7321 cattacattt cctgccggat tcatgaaatt ttctggtctt gtcattggat ttctataatt
     7381 tttcttcata aggcacgctc ctaactgctt cttgcataga taccatatgt aaattcaaaa
     7441 tgtctatatc tatacgattt aatttttcac aaaatactgc aggaatacag aacccttcag
     7501 gttcatccta agatatttat tttttcattt ctcatttcct taaaaggttc tgttaagttc
     7561 acttgactag cagtatgtat tttctcttct ccttccttac aaacatatat taaaattgtt
     7621 tatgattacg gacaacattt ctttacattc aatccaccat tttttaccac cctttccgtc
     7681 ttgtttgttt tacctttact tttctttttg atttcatata aacattcttt ttggttctgt
     7741 ttagcatttg aaacaatagt atggaaacca ccaaaacccc aattatagac atcgccgcag
     7801 gaggaatttt atatgttatt ccatattcgc ttccgcattt aggatcaaca agtatcattg
     7861 cagccttgat tggaaaccaa ttaagcatac ttccttccat tgttgcaaaa tatccgtaga
     7921 tgaatgcaac ggcaactccc agcaatgatt ttccttctgc aaaagcacaa acaataataa
     7981 tgggaagtac tgatatatac accaatatgt cagatacaat aatctgagcg gctgacatca
     8041 gcatcatatg aatattcatt ccagaaaatc ctaaaaaagc attaaaacat attgacaaaa
     8101 gagcgttaaa aatactaaaa actatagtta aaaataaaag cagccaaaat ttagcaataa
     8161 gtaacttttt atatgaaata ggtactgtta aaatagattt taatgtatca tctgttgttt
     8221 ccctggaaat aatgtacaca gcgactaatg taataataat cgggaaaaat aatgtacaat
     8281 tactaataat tacctgctgt ataaaatact gaaaatccca tactttattt gtgcttgcaa
     8341 ttgaataaaa gcaactcatt aacacagata gcgacatcat aactaatcca gcttttacaa
     8401 ctgaatatct tttaattttt aataactctg ttgatataat atttcccatt taaattacct
     8461 cgtccatttt ttataaaatc taatcataag cattaaagat aagaacaatg ttactcctaa
     8521 taccaaaaat gcataaatat ctgacggaaa cataatatat gcttcttttg acaaattatc
     8581 ttttattaca tgatctacca gtttaccgct tgtccagtcc atcgcacata taactggaaa
     8641 tagatttaga aattttgcgg tacctttcac tgccattgtt tcaaataaac cgataattcc
     8701 ccaatttaga atcgaataaa aaaatgccaa caatgtagac actaaatagg atttattaaa
     8761 atatactatt ataaccacaa taggaagtga cgctatcgtt atcacaagcc caaatataat
     8821 actaaatcct agcttgtatg ctaaatcata tataatacca accttcaata tccatgaaaa
     8881 gaatattgta aatgatacac tcgccaggct aaaaagagta ccatatataa aaagtacaca
     8941 gatctttgca aggatcattt tggtaattgt cacgggcact gttctaatat ttttaaatgt
     9001 atcattatct cgttccataa agaacaagat tgtcgcaagc attcctatta aacaaggtgc
     9061 aaggaataca agaccatagc cctgtgtcat agtaaaggat aaatcaaacc tcattttcaa
     9121 ataatgtgtg ctcagatcac cagacatccc gttcttagtt gtcataacca caattaaggg
     9181 gaaaaaacat gataatacaa tcagcatgag cgtgattttc cttcttttca attttgtaaa
     9241 ctcacatctg actaaatcaa gcaattcctt cccctcctgt cactttttta aaatagtcct
     9301 ctaaagtatc ttcacacaaa tgagcgtcca tcacgtctac tccttcttga acaaaggaac
     9361 gaactatatc tggtattgat atactgagat tatacacatt tatatcttgg tttcctgata
     9421 ccttaaaatt tgattcttta taatacactg acagtattct tgctgcttgg gcattatcag
     9481 aaaccttgaa gtgtatatat tttccatttt tttcttctaa ttccttcata cttccctctt
     9541 caatgagtac gcctttatca atgataccaa tatcgtctgc taaaacagca atttctgaaa
     9601 gtatatggct agagatcaat atagttttcc ctctattttt agataaatct tctataaatg
     9661 ttcttatttc tgcgattcct atcggatcta agccattaat tggttcatcc aaaattaata
     9721 tttctggatc atgcattacc gctaatgcta tagctaatcg ctgtttcatt cctaatgaat
     9781 actgcgaata taacttttta tctttatatg gtaaattaac aagttttaat gcctgttcga
     9841 tagcatcagt tcttgggatt cctctcaatt tcgcaaaaat tctaagattt tccgtacctg
     9901 tcaaattagg gtaaaatcca ggactttcaa tcagtgatcc tattcgaggt aatatttttt
     9961 tctcttcaag ccttatatct ctattaaaaa tacgtatgga acctgatgtc ggttctatga
    10021 ggtttagcag cattttcata gttgtggttt ttccagctcc atttctccct aaaagtccat
    10081 atatctttcc ctttcttaca tgcatattta gattggaaac acttttctgt tctccatatg
    10141 ttttagttaa atcacgtgtt tgtataatgt attgtgacat ttggtttttc tcctttcaga
    10201 atcttctatg ttttacagta taatatattt ttctgacagg aacctgacag aaacctgaca
    10261 agaaccttgt aatttattta atacgaaaaa gatgatactc gaacgtatca tcttttttgt
    10321 tacctttgta taactgaaaa ttcaatacaa aatactgttc ctttacccgg ttcactaaat
    10381 gcactaattg tcccacccat tttctctagc aataattttg aaatatttaa tcccagtcca
    10441 ttcccttttc cggatcttcc tttattacac cggtataatc tttcaaaaat ataattcaaa
    10501 tcttcctttg ctatccctat cccatcatca cctatctcga gtctaaattt accattcccc
    10561 tctgatgctg ttattgatat gtttgctgct ttgctatgag taaaaatatt ctgcacaata
    10621 ttatttatag ccctcatata acaatcctca tcaatctcaa caattatagc tttctcagga
    10681 atttctatat tatatcctat tcgatgttct tctattatag ggatccaatc caaaaaaatc
    10741 cttctggttt cttcagtaat gtcaactgct tttatttcca actgttcctc atctgaatta
    10801 atcctaaacc actcgaataa cacttcgata tattttttta agtcatacgc cttttctttc
    10861 gctagtctta gatattgttc ctctttatct gaacttacca gttttaaatc tagagcgtcc
    10921 aaatacccta ttaaggttgt catgggtgtt ctgacatcat gtgataaact tgtcatgagt
    10981 tgcttatttg cttccaactc tatgttactc tcttcgatcc ttttttcata tttatacaat
    11041 atagaattta ctctaaatcc aacttgatct atcctattat tttttttcaa tagaaacttt
    11101 tgtttgcttt gacctttctc tatttctaaa agtatttgat tgaactcttt tagtcttcta
    11161 ttaattttaa acacataaag tgtcaatccc aaattataaa ataaaagtat gactagcacc
    11221 acataaaata atttcattta tctcataact ccttattgaa tctatatcca agacctctta
    11281 cagtctgaat atacgaattt tctgctgttc gctctatttt ctttctcaat ctgctaataa
    11341 ctgccattat gttatcatca tcatatacat actcttcgtt ccaaacattt tcgtatattt
    11401 gtttcttcgt gagaattttt ccttgatttt ttgcaagata tataagtaca tcatattctt
    11461 ttgcagataa tttaagctct tcaccagaca attctactat gccactttct aagtcaattc
    11521 ttaaatcgcc atatttcaaa attgctttac tagccatatt atttaaacgt gtgtaacgtc
    11581 ttattagaga taatactctt gcaaaaaact cttccatttc aaaaggtttt gtcaaataat
    11641 catcagctcc cgcccgcaac ccttttactt ttgaggtgct gtcatctttc gctgtaagca
    11701 ttagtattgg tacattactc atgtctcgta ttctttctaa aacttcaaaa ccactgattc
    11761 ctggcatcat cacatccaat acaactaatt gatattcctt atcttttact gattttatcc
    11821 catcaaaacc gttgcatgaa atatctgcac aaatattttc ttgcaaaaga ctctcttgca
    11881 agagtgtaca taaatcccta tcatcatcaa taattataat atcttttctc atctcaagcc
    11941 tccagtaata tgtatatctc ttcaaattga ttgcaacaat tatattggta attattttat
    12001 cactatatta accgtttgta tcttacaata ttcttgtaat tcatatatcg aaccattttg
    12061 gctaactctt tatatatcaa atttttattt cttcatctca acttgacaaa cctctacaat
    12121 taaaaaaaat tcacccatac tagaataatc tgacaacgat tccaggtagg ggaacatatt
    12181 ctggtccgaa tcttaactat cccgggagat tccccagaaa cgctctccat ccatgcagat
    12241 gtaaaaatcg tggaaggcaa caccagcaaa gaaaatctga aaagttgtcg ggtacaggga
    12301 aaatatgccg gaacggtgga agacatccac aaaggaactg tttttgtccg gttagaattg
    12361 ggcgtcaacg ccattgctca cagttgctac gacagccgca ccgttgggaa gaaagataag
    12421 gtgtcctttg ttgtgacaca tattgatgaa gaacggaatg ttgcagtggg gattatcact
    12481 cgtattatta aacagagtat ttaacagtcc ataatgtgaa aggtaggaaa tcaactgaac
    12541 gctttcctac cttttctgtt atcttttctc accctcatac tcaattttca aaccaaaaat
    12601 atattgcagt ttatgaagca aaagaacaaa tacaatgccc atatattaat ttataaaatt
    12661 cttttattag tagatatact ctattttatt ctatctatca gactctctct cttgtaaaaa
    12721 ttaataatta tataggcaaa tatcatttga acaataataa gtattgaaaa atataccgtc
    12781 atttctttaa atgggaagtg atatatcact tttccaaaaa cactaaagga actaaataca
    12841 ttacacagta taatcccaaa aatagttcca aaaatcaaag aaattgaaat cgaaccaacg
    12901 gaatataaga ttccctcttt tactactata gatgataatt gtttatcagt tagacctaca
    12961 cattgtagca ttccatattc tcgtttacgt gttgccatat ttgaaaacag catatttagc
    13021 aaattaacaa taccaaaaat tcctacaaat ataactaaac cataaactgg ctttctatat
    13081 gcatctatcc tttgtttata tgaagcagca acatcatcta tggtagtaaa ttggataggc
    13141 atttcatttt gaaacatctt tctaatcata tcttctgttt ttgaaacatt tgtatcactt
    13201 gttgttttta tactcaattg ataagttaaa tttaatacat cttttcttaa ttcttccata
    13261 ttagataaag gcatatacac catattgtag ccgccataat cagcaccatt ttctacaatt
    13321 cctacaacct catattttac tggtacaccc tcgctatcta aaatattaat tgtatcacca
    13381 attttaactt cccaatccca taaagtttcc cactcacttg cttccgaaac tacaattcca
    13441 tttttctgtt gcattttctt aaaatctatt tcaccatcta ctaaaaattt ctttaaatta
    13501 gtaatatccc ccgattgtat tccgtccaca acaaaaatat ctgtatcgcc attcggtaat
    13561 gttatgtcac aaactgttcc tttatactgt ttaattgatt cgacagcttg catatcctct
    13621 aattttttta gcaactcttg atttaaaata ttattttttt gtaaatcaaa atattgttta
    13681 ctcgtataag actgtggtcc gtatgttcca agttcaattt ttatttcacc atttggcatt
    13741 gatttttttg ccatattata tggatcaata gaatttaagt aggaagagct agccataaga
    13801 actattccac aaattcctaa agaaagtatt gttaaaaacg tttttttctt attacgctgc
    13861 acacttaaca atgctaatct ccacaatgta atttttttat atgaatgttt cctatttata
    13921 tttacctctg tatctgcaaa atatcgtaat gcttctattg gagaggctgc agatgctatt
    13981 tttgctggtt tataaagaga taacattaca acaaaataaa caaacgcact cgccatacct
    14041 gatattaaaa tagtattcac taaataccat ccttttggtt gaataaagta agctataata
    14101 cccccaaaaa cacatcccca aaaacaacct tttagagtta aaacattccc ttctattttt
    14161 attatttttc tgatttgctt tttagtcata cccaatgttc tcatctgtcc atattttcca
    14221 attctctcca aaacagaaac aaaaaatata ctataaataa ctatacttga tataattgca
    14281 atgactaaac tcacgcccaa aataacactt atatattgaa tacttttctg actaataaga
    14341 gaaaaataat aagatgaata aacaatgcta tcctttggta catctaattg ttgtgctatt
    14401 ttatcaattt cactctttat tccggcttcg ttccagcctt gagtatcgtt aattttaaaa
    14461 tatatgctat ataaagcccc tggcattttt ctttcaatca atttatcaga tacatatatc
    14521 gaatgtgtat ctgcagtact ctgcataggt aaaattcctg caataacata gctttctttt
    14581 ccatctccta aatctatctc tatagaatca cctattttgg cctttgattg aacctcttct
    14641 aaatatgaat cagttactac aacttctttt tccatttcag gtaatttccc ctttaattcg
    14701 ggatatcttc ctaactttag taacgactct gtcattgttc ttatagtaat tttataagtc
    14761 ccctggttta atgtccccag tgttctagtt tctcccattt caacattctt catggctttc
    14821 attttattga caaccttaga attaacatcc ataaatgtcg cttgataccg accttcagca
    14881 tcttgaattg aaaaacgttg tgtttgtaca aaataaagtg ttaccactat aattaatgct
    14941 gttgacaata ttatcgttaa aatgccacaa aacttcttta acctcacact attcaaatcc
    15001 tgtcttgcta aatgccctat tacctttttt tcattattgc ctttcatttt tcctacctca
    15061 attctatata aatttacgaa aaatcccatt ttcaaaacca aattctgatt ttgaaaatgg
    15121 gtttttccta gcacatctta ctgctctggt gataaccaat aagtaccgtc taagcaatca
    15181 gttaagcaat cttttctcag tttaccgtag caaataatga cgagatcata cgcattaact
    15241 tctgcctctg ttaattcctt attctcttta tgttccagca ttttgactcc tcctttcatt
    15301 aaaaatttat ataaaattat atatgtcttt ttgactatct ttttatatct tcttaaatgt
    15361 ccgtaaag
//
