LOCUS       c00063_gnlPro..        12603 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LLILHNAC_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:04:30
            Original ID  :: gnl|Prokka|LLILHNAC_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12603
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12603
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2150:11639]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2151..11639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     protocluster    1..12603
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[609:11639]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="2"
                     /tool="gutsmash"
     proto_core      610..11639
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /neighbourhood="10000"
                     /product="Arginine2putrescine"
                     /protocluster_number="2"
     cand_cluster    1..12603
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(3, [AdoMet_dc, Amidinotransf,
                     Arginase, OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="chemical_hybrid"
                     /product="Arginine2putrescine"
                     /product="Putrescine2spermidine"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12603
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2putrescine"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(3, [AdoMet_dc, Amidinotransf, Arginase,
                     OKR_DC_1, OKR_DC_1_7_arginine, OTCace]) or
                     ((OKR_DC_1_5_ornithine or OKR_DC_1 or Orn_Arg_deC_N) and
                     minimum(1, [Arginase, OTCace, OTCace_N, PAD_porph])))"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             610..2079
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: OKR_DC_1_7_arginine"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_1"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.1e-11, bitscore:
                     34.9, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 7.7e-131,
                     bitscore: 426.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAGSQKRAPVYEALEQLKKRRVVPFDVPGHKRGRGNPELVELLG
                     EKCVSLDVNSMKPLDNLCHPVSVIKEAEELAAEAFRADHAFFMVGGTTSSVQSMVLSVC
                     RAGDKIILPRNVHKSVINALVLCGAIPVYVNPEVDKKLGISLGMEISEVERAILENPGA
                     VAVLVNNPTYYGICSDLRSIVKLAHEHEMLVLVDEAHGTHLYFGEDLPVCAMDAGADMA
                     SVSMHKSGGSLTQSSLLLTGKNVNWEYVSQIINLTQTTSASYLLMSSLDISRRNLALRG
                     RESFRKVAEMAEYARAEINDIGGYYAYGKDMVNGGSVYDFDVTKLSVYTRGIGLAGIEV
                     YDLLRDEYDIQIELGDIANILAYISIGDRIQDIERLVGALADVKRLYSKDPAQMLNTEY
                     INPTVLVSPQAAFYAEKKCMPIRETAGKICGEFVMCYPPGIPILAPGEMITPEIIEYII
                     YAKEKGCSMQGTEDPAVEHLNVLVDDRQVWK"
     CDS             2151..3044
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_2"
                     /sec_met_domain="Spermine_synth (E-value: 5.8e-54,
                     bitscore: 172.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.4e-14,
                     bitscore: 43.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEYGLGKVEESVELWFSDNQTDHVKVSVKVEKQLFGEQTDFQRID
                     VFESREFGRFLSSDGSIVFSEKDEFIYDEMIVHVPMAVHPHVKKVLVIGGGDGGVAREL
                     SYYEEIEQIDVVESDRTFVDVCRKFFPDNACGLEDPRVNIYYEDGLRFLRTKHDAYDLI
                     INDAIDPLGHTAGLFTKEFYGNCYRALKEDGIMVYQHGSPFYDEDEESCRVMHRKASHS
                     FPISRVYQAHIPTCSSGYWLFGFASKKYHPLTDLNVERWKARGIKTWYYTTNLHKGAFM
                     LPKYVEDMLEEEEGRK"
     CDS             3178..4437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_3"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 3.2e-44, bitscore:
                     141.8, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.8e-34,
                     bitscore: 108.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLLIIGCGGVAGVAIHKCCQNSKTFSEICIASRTKEKCDALKE
                     KLQGTTDTVITTAKVDVDNVDELIALIRDYKPDAVLNVALPYQDLTIMDACLACKVDYI
                     DTANYEPEDTDDPAWRAIYEKRCKEAGFTAYFDYSWQWAYQKRFADAGITALLGSGFDP
                     GVTSVFTAYALKHYFDEIEYIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETKPMEIKREYNFPQVGEKDMYLLHHEEIESLAKNVPGVKRIRFFMTFGQSYLTHMQ
                     CLEDVGMLSTSPIQYEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGKKDGKEK
                     TIYIYNVCDHQECYREVGSQAISYTTGVPAMIGAALVVDKVWDKDGVFNIEEFDPDPFM
                     DMLNQYGLPWVVDENPETVA"
     CDS             4477..5673
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_4"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 2.7e-15,
                     bitscore: 46.3, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWNELPTPCYVVDQKKLKENLIILHNLEQDTGCHVLLAQKAFST
                     YALYPLIGQYISGTTASGLYEARLGAEEMGRENHVFAPAYKDSDMEELVTLCDHVIFNS
                     FAQYVRHRKKVAAQNVASGTEHRVSIGLRINPEYSTQEGHAIYDPCAPGSRLGMTREAF
                     EKGLAGLGMRRQEDGSYELPEDVEGLHFHTLCEQDADDLERTFLAFEEQFASYLKQVRW
                     LNLGGGHHITRPGYQIERLKKLIGYIRETYGLAVYLEPGEAVALNAGYLVTEVCDIVHN
                     GMDILILDASAACHMPDVLEMPYRPPLRDSFPAGEQKYTYRLSSLTCLAGDVIGDYSFT
                     HEIQIGDRLVFEDMAIYSMVKNNTFNGIPLPSIAMLREDGEVEMLKQFGYEDFKGRLS"
     CDS             5730..6953
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: PAD_porph"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_5"
                     /sec_met_domain="PAD_porph (E-value: 1.1e-117, bitscore:
                     382.6, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKMQKCAEDPKERMTTPQTDGFFMPGEYEPHDGCILIWPSRPG
                     SWIYGARDARIAFRDVIAAIAQSENVYVAAGRDAIDSAREMLTGEDAPWKKRVTVFELE
                     TDDAWARDVAPTFVKDGAGRVRAVNWSFNAWGGSVDGLYASWALDDAFAKAFAAKYGYA
                     CYDAAPFVLEGGSIHSDGEGTLLVTEACLLSAGRNPGLTREEIEEKLRTYLGIKKVLWL
                     PRGIYQDETNEHVDNVCAFLRPGEVVLAWTDDETDPQYPLSQQTLAYLEGETDARGRKL
                     VIHKLPIPDHPVCITEEELAGYSFAEGEDEREAGERLAASYVNFYFSNEAVVLPAFGGE
                     NEESDRRAAALLAQWNPGRKIIPVQARAILVGGGNIHCITQQIPAAKMQQQKCSSGKVD
                     RDKKRKRV"
     CDS             6950..7828
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_6"
                     /sec_met_domain="CN_hydrolase (E-value: 9.4e-56, bitscore:
                     178.7, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRVKVAAIQMRCAASVEENLKKAEAMVRKAAAEGANVILLPELF
                     EREYFCQQRRYDFYHYAKPVMENDAVRMGMRLAAELGVVLPISFYERDVNNLYNSIACI
                     DADGTVLGVYRKTHIPDDHYYQEKFYFTPGDTGFQVFSTRYGRIGVGICWDQWFPESAR
                     CMALAGAELLFYPTAIGSEPILECDSMPHWRRCMQGHAAANLMPVVAANRIGEETVEPC
                     EENGGQRSALVFYGSSFLTDETGEILAEAGRDEEEILVQEYDLDELDARRLEWGLFRDR
                     RPECYGIISGR"
     CDS             7859..8389
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MRYSRNWEQNTMLEKGRVCMKDREELLKEIALMLERQDMLSKLTE
                     NQCLDEYGYSETHCIDYIGRLELPNVTKVAEHMGMTRGAISKMTKKLLAKGLIEKYTLE
                     TNKKEVYFKLTDQGRLLFDEHAKRHKRWEKRDMEFLARYSVEDVRTVSRFMTEFNGYLE
                     EQIETITGTQAEG"
     CDS             complement(8481..9182)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MSITILNYHDQAFVDQINTEAAARAEAERAAAEAAKAQAAGSDFS
                     SVLTNATDAYSGSTACSEDLSAIFDEAANTYGVSSTLLKSIARAESNFNTSAVSSAGAV
                     GIMQLMPATAASLGVTDSYDAYQNIMGGANLISQLLARYNGDTSLALAAYNAGSANVDK
                     YGGIPPFSETQNYVQKVLSYMGSDTNTVASASTAETSEDVATTVSNFIAANNISQDTVE
                     KLLTLLEVLNA"
     CDS             9265..10020
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="MKTKQAEQKGTYLRAFRAAFPYTVPVLTGYLFIGMAFGVMIQEKG
                     YNFLWAMLMSLVIYAGSGQYLAVNFFAPGVSLFNVIFMEFMVNIRHIFYGLSLLERFSE
                     MGKKRLYMIFSLTDETYSLFFVTKVPKDVKEEQFLFAIAVLDQSYWIIGSGIGALLGNV
                     LPFSAEGIDFAMTALFVVIMVEQWMEKQNRPSVVIGLVCGLVCRLVFGADNFILPTMIC
                     VMVILLSCKKIFDKMIPEDGKEGGEPECQ"
     CDS             10011..10343
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="VPVSVGRSLAIIFTVAGTIFFTRLIPFLFFPKGKEIPPIIRYLGR
                     VLPPAVIGMLVIYCLKNVSVLAVPFGLPEFIAVAAVIVLHVWKRNNLLSIGVGTALYMF
                     LIQVVF"
     CDS             10362..11639
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2putrescine: Orn_Arg_deC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_11"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 5.4e-29, bitscore:
                     91.0, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 8.2e-22,
                     bitscore: 67.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKPFVTKEQLEEIVKKYPTPFHLYDEKGIRENAKAVKEAFAWN
                     PGFREYFAVKATPNPFILDILKEYDCGCDCASLTELMLADSQGFDGKHIMFSSNDTPAE
                     EFAFANELGAIINLDDFTHIDFLEKTIGRIPETISCRYNPGGVFKMSNGIMDNPGDAKY
                     GFTHEQIIEGFKILKEKGAKHFGVHAFLASNTVTNEYYPKLARELFELVVELRDKTGCD
                     IRFINLSGGVGIPYTPDQTPNDIRVIGEGVRVAYEEILVPAGLGDVAIYTEMGRFMLGP
                     YGCLVTTAIHEKHTHKEYIGVDACAVNLMRPAIYGAYHHITVMGKEDAPCDHKYDVTGS
                     LCENCDKFAIDRMLPKIDMGDLLVIHDTGAHGFSMGYNYNGKLKSAEVLLKEDGSTQLI
                     RRAETPEDYFRTFDCFDILKDMKHPK"
     CDS             11683..12432
                     /locus_tag="ctg63_12"
                     /transl_table=11
                     /translation="MCIDTERFERARGRVIGIERQRLGIGTLSEKTVHAVLKNYYAPDE
                     DMHEIPIENFVADIFDGEAVIEIQTRSFQNMRRKLAAFLPLYPVTIVYPIPHVKWLHWM
                     DEETGEISPGRKSPKKGNAYQAFIELYKIRPFLKDPNLRLRLDLIDMEEYRLLNGWSRD
                     KKKGSDRFDRIPLTFVEEVRVDRREDYMQFIPYEIPEEFTAKDFAACAKIPVRLAQTVL
                     LILTDLLIVERIGKQGRSYLYRICEIE"
     CDS             12533..12601
                     /locus_tag="ctg63_13"
                     /transl_table=11
                     /translation="MKNTAIKLSGILLAGAVFFSTLL"
ORIGIN
        1 cgggagtaaa ttctaccaca taagcgagca gtggaattta aataaaaaat ttaggagtag
       61 ataagaatcc agagaaatac attgcttttt agaagtgtgt gtgttatact tcaaatcaca
      121 tgaatgcgaa agctttttca tgcaaatatt tgcccaccaa gagattggtt aagcccatac
      181 ggacaggcgg ggcagctgcc gatggtggag agatccacgt tattgattga gttagaagct
      241 caaattttat aagttgatga cgactgcagg cgaaggactg caggaccctg aatcgtatgc
      301 gatagagata tcacttgtga aacggtcaat aagagtagta atagcaaata tttgctggcg
      361 aagatgccaa cgtagactct gataatagtt tttgcagcat gtaggacaga ttacataaag
      421 tatgactatg agaatgtgac aaggcaggtg atgtgtgcgc agcatacagg catctgtctt
      481 tttttgtgta ataggaaact tcgtccctat tacataaaaa cgttccgcgg ggatgcgtac
      541 ctcgcggtga ggtacataat gctttgcata ccgcatcagg gagcatcaaa acagaatgtg
      601 aggagaatca tggaagcagg atcccagaag cgcgctccgg tctacgaagc gctggaacaa
      661 ttaaaaaaga gaagagtcgt tcctttcgat gtgccggggc acaagagagg gcgtggcaac
      721 ccggagctcg tggaacttct gggggagaaa tgtgtgagtc tggatgtgaa ttccatgaag
      781 ccgcttgaca acctgtgcca tccggtgtcg gtcatcaaag aggcggagga actggcggcg
      841 gaggctttcc gggcagatca cgcgtttttt atggtgggag gaacaacgtc ctccgtgcag
      901 agcatggtgt tgtcggtctg tcgtgccggg gataagatca tcctgccgcg caatgtacat
      961 aagagtgtga tcaatgcact ggtactctgc ggcgctattc cggtctatgt gaatccggag
     1021 gtggacaaaa agcttggcat ttcactcggt atggagatct cggaggtgga gcgggcgatt
     1081 ctggagaatc cgggcgcggt ggcggttctt gtgaacaatc cgacttatta cggaatctgt
     1141 tccgatttgc gctccatcgt gaagctggca catgaacacg agatgcttgt gcttgtggat
     1201 gaagcgcacg gcacccatct gtatttcggg gaggaccttc cggtctgcgc gatggatgcc
     1261 ggtgcagata tggcgtccgt ctccatgcac aaatccggag gaagcttaac acagagctcc
     1321 ctgcttttaa caggaaaaaa tgtcaactgg gagtatgtca gccagattat caacctcacc
     1381 cagacgacaa gcgcgtcgta tcttctgatg tcaagtctcg acatttcgcg gagaaatctg
     1441 gcgctgcgcg gaagggaatc gttccgcaaa gtggcggaga tggcggaata cgccagggcg
     1501 gagatcaacg acatcggcgg atattatgct tacggcaagg atatggtgaa cggcggaagc
     1561 gtctatgact ttgatgtgac gaagctctca gtctacacgc gaggaatcgg tctggcagga
     1621 atcgaggtct atgatctgtt gcgggatgag tacgatatcc agattgagct gggggacatt
     1681 gccaacatct tagcctacat ttcaatcggc gaccgcatcc aggatatcga gcggctggtg
     1741 ggagcgttgg cagacgtcaa acgcttgtat tccaaggatc ctgcacagat gttaaataca
     1801 gaatatataa atccgaccgt tcttgtttca ccgcaggcgg ctttttacgc agagaaaaaa
     1861 tgcatgccga tccgggagac ggcaggaaag atctgcggag agtttgtgat gtgctatccg
     1921 ccgggaattc cgattctcgc gccgggtgag atgattacgc cggagatcat cgaatatatc
     1981 atctatgcca aggagaaggg ctgctccatg cagggaacgg aagatccggc ggtggagcac
     2041 ttaaatgtct tagtggatga ccggcaggtg tggaaataag accgccggaa gaatagctct
     2101 taaggaagag catacggtca ggaagaaccg gcagaaggaa gcagcagacc gtggaatacg
     2161 gtctggggaa ggtggaagag agcgtggagt tatggttttc ggataatcag accgatcatg
     2221 tgaaggtgtc ggtcaaagtg gagaagcagc tgttcgggga gcagacggat tttcagagga
     2281 tcgacgtgtt tgaatccagg gaattcggca gattcttaag ctccgacggc agcatcgtct
     2341 tctcagaaaa ggatgagttc atctacgatg agatgattgt gcatgtgccg atggcggtgc
     2401 atccgcatgt gaaaaaagtg ctggtcatcg gtggcggaga cggcggtgtg gcgagagaac
     2461 tttcctatta tgaggagatc gagcagatcg acgtcgtgga atccgaccgg acattcgtgg
     2521 atgtgtgcag gaagtttttc ccggacaacg cctgcggact ggaagatccg cgcgtcaata
     2581 tctattacga ggatggactg cgctttctgc gcacaaagca tgatgcctac gatctgatca
     2641 tcaatgatgc gatcgatccg ctcgggcata cggcgggatt gttcaccaag gaattttatg
     2701 ggaactgtta ccgcgcatta aaagaagacg gcattatggt ctaccagcac ggcagtcctt
     2761 tttatgacga ggatgaggag tcctgccgcg tgatgcaccg caaggcgagt cacagtttcc
     2821 cgatcagccg tgtgtatcag gcgcacattc cgacctgttc ctccgggtac tggctgttcg
     2881 gatttgcgtc aaaaaaatat cacccgctga cggacctgaa tgtggagcgc tggaaagcgc
     2941 gcgggatcaa gacctggtat tatacgacca atcttcataa gggagcgttt atgctgccaa
     3001 aatatgtcga ggatatgctt gaggaagagg aaggcagaaa gtagatggca gatgcgggac
     3061 agaacggact ctgacgggac agtcagcgga gcgttctgtc atccgttggc agaatgatat
     3121 aaataatata aaaatagaaa atacagccgc gggacggcag gaagagagga taagtagatg
     3181 ggaagattat tgattatcgg atgtggcgga gtagcagggg tggcaattca caaatgctgc
     3241 cagaacagca agactttttc ggagatctgt attgcaagcc gcacaaaaga aaaatgtgac
     3301 gcgttaaagg aaaagctgca gggaacgacg gatacagtga tcacgacagc gaaggtggat
     3361 gtggataatg tggacgaact gatcgcactg atccgtgact acaagccgga tgccgtgtta
     3421 aatgtggcgc tgccttacca ggatctgacg attatggatg cctgcctggc atgcaaggtg
     3481 gactacatcg ataccgcgaa ctacgaaccg gaagataccg acgatccggc gtggcgtgca
     3541 atttatgaga agcgctgcaa ggaggcgggc tttaccgcgt acttcgatta ttcctggcag
     3601 tgggcatatc agaaacgctt tgcggatgcc ggcatcacgg cgcttcttgg cagcggcttt
     3661 gaccctggcg tgacgagcgt gtttaccgcc tatgcgctga agcattattt cgatgagatc
     3721 gagtacatcg atatcttaga ctgcaacggt ggagaccacg gttatccgtt cgccaccaat
     3781 ttcaacccgg agatcaacct ccgcgaggta tccgcaaacg gctcctactg ggaggacgga
     3841 cactgggtag agacaaaacc gatggaaatt aaaagagaat ataatttccc gcaggttggc
     3901 gagaaagaca tgtatctgct tcatcatgag gagatcgagt ctctggcaaa gaatgtgccg
     3961 ggagtcaagc gcatccgctt cttcatgacc ttcggtcaga gctatctgac ccatatgcag
     4021 tgtctggagg atgtcggaat gctctccact tccccgatcc agtatgaggg aagagagatc
     4081 gtgccgatcc agttcttaaa ggcattgctt ccggacccgg cgtcactggg tcctagaacc
     4141 gttggcaaga cgaacatcgg ctgtattttt accggcaaga aggatggcaa ggaaaagacg
     4201 atctatatct acaacgtctg cgatcaccag gagtgctaca gggaggttgg ctcacaggcg
     4261 atctcctaca cgacaggagt tccggcaatg atcggtgcag cgcttgttgt agataaggtg
     4321 tgggataagg acggcgtttt caatatcgag gagtttgatc cggatccgtt tatggatatg
     4381 ctcaaccagt acggactgcc gtgggttgtc gatgagaacc cggagacggt ggcgtagccg
     4441 ttcgtaaaaa gagccggaca gggagagacg agagcaatga agtggaatga acttccgaca
     4501 ccatgctatg tggtggatca gaaaaaatta aaagagaatt taataatatt gcataatctg
     4561 gagcaggata cgggatgcca tgtcctgctg gcgcagaaag cgttttccac atatgcgctc
     4621 tatccgttga tcggacaata catcagcggt accacagcga gcggactcta cgaggcgcgt
     4681 ctcggcgcag aggagatggg gcgtgagaac catgtgtttg ctccggcgta caaggacagt
     4741 gacatggagg aactggtcac gctctgcgac catgtgattt ttaattcctt tgcgcagtat
     4801 gtcagacaca ggaagaaggt ggcggcgcag aatgtcgcca gtggtacgga gcaccgtgtc
     4861 agcatcggac ttcggatcaa tccggagtat tccacgcagg agggacatgc gatctatgat
     4921 ccctgcgcgc ccggttccag actaggcatg acaagagagg cgtttgagaa aggacttgcc
     4981 ggacttggca tgagacggca ggaggatgga agctatgaac tgccggagga tgtggaggga
     5041 ctccattttc acacgctctg cgagcaggac gcggatgatc tggaacgtac gtttttggcg
     5101 tttgaggagc agtttgcttc ttatttaaaa caggtccggt ggctgaatct gggcggagga
     5161 catcatatca ccagaccggg ttaccagata gagcgtttaa agaagcttat cggctatatc
     5221 agggagacct acggacttgc cgtgtatctg gagcccggcg aggcggttgc cttaaatgcg
     5281 ggatatctgg taacggaagt gtgcgatatt gtacacaacg ggatggatat tctgattctg
     5341 gatgcgtctg cggcgtgtca tatgccggac gttcttgaga tgccgtatcg cccaccgcta
     5401 cgggacagct ttccggcggg agaacagaaa tacacctacc ggctgtcctc gctcacctgt
     5461 ctggcggggg acgtcatcgg ggactacagt ttcacacacg agattcagat cggcgaccgt
     5521 ctggtgtttg aggacatggc aatctactcg atggtgaaga ataatacctt taatggaatt
     5581 ccgcttccgt cgatcgcaat gctccgggaa gacggggagg ttgagatgtt aaagcagttc
     5641 ggctatgaag atttcaaagg gcggttgtca taaccggttt tgaaagacat ccgggacaag
     5701 ggaagatgac ttggatgagg gtagaggaaa tggagaaaaa gatgcaaaag tgtgcagaag
     5761 acccaaaaga gagaatgaca acgccgcaga cggacggatt ttttatgccg ggggagtacg
     5821 aaccgcatga cggctgcatt ctgatctggc cgtcgcgccc gggttcctgg atttacggcg
     5881 cacgcgatgc gcggattgca ttccgggatg tgattgcagc gattgcgcag agtgaaaacg
     5941 tatatgtggc agccgggcgg gatgccattg actccgcgcg agagatgctg accggtgagg
     6001 acgcgccgtg gaaaaagcgt gtgacggtct ttgaactgga gacagacgat gcctgggcaa
     6061 gagatgtggc accgactttt gtgaaagacg gcgccggcag ggtgcgggca gtgaactggt
     6121 catttaacgc ctggggagga tcggtggatg gactgtatgc atcctgggcg ttggacgatg
     6181 cgtttgcaaa ggcgtttgcc gcaaagtacg gctatgcgtg ttacgatgcc gcgccgtttg
     6241 tactggaggg cggatcgatt cacagcgacg gtgaggggac gcttctggtg acggaggcgt
     6301 gccttttgag tgcggggcgc aatccggggc ttacgcgcga ggagatcgag gagaagctta
     6361 gaacgtatct tggcataaaa aaagtgctgt ggctgccgcg tggaatctat caggatgaga
     6421 cgaacgagca tgtggataac gtctgcgcgt tcctgcgccc gggcgaggtg gtgcttgcat
     6481 ggacggacga tgaaacagat ccccagtatc cgctatcaca gcagacgctt gcgtacctgg
     6541 agggcgagac ggatgcgcgc ggaagaaagc ttgtcattca caagcttccg attcccgatc
     6601 atccggtctg cattacagag gaggaactgg cagggtattc gtttgccgaa ggggaggatg
     6661 agcgggaggc gggagagcgt cttgcggcat cctacgtgaa cttttatttt tccaacgagg
     6721 cagtcgtcct tccagcgttc ggcggggaga atgaggagag tgacaggcgc gctgccgcac
     6781 tgcttgcgca gtggaatccg gggcggaaga tcattccggt gcaggcgcgt gcaattttag
     6841 tcggcggcgg gaatatccac tgtattacac agcagatccc ggcggcaaaa atgcagcagc
     6901 aaaaatgcag cagcggtaaa gtggacagag acaaaaagag gaaaagagta tgaacagagt
     6961 gaaagtggcg gcaattcaga tgcgctgtgc ggcatctgtg gaggagaatt taaaaaaggc
     7021 ggaagccatg gtgcgaaagg cggcggcaga gggagcaaac gtgatccttc tgccggaact
     7081 ttttgagcgg gaatattttt gccagcagcg ccggtatgac ttctatcatt atgcaaagcc
     7141 tgtgatggag aacgatgcgg tgcgcatggg catgcggctt gccgcggagc ttggcgtggt
     7201 gctcccgatc agcttttatg agcgggatgt gaacaacctg tacaattcca tcgcctgtat
     7261 cgacgcggac ggaacggtgc tcggcgttta tcgcaagacg catatcccgg atgatcacta
     7321 ctatcaggaa aagttctatt ttacgccggg ggataccgga tttcaggtat tttctacgcg
     7381 ctacggcaga atcggcgtgg gaatctgctg ggatcagtgg tttccggaga gcgcgcgctg
     7441 tatggcgctt gcaggggcgg agctgctttt ttatccgacg gcgatcggat cggaaccgat
     7501 cttagagtgc gacagtatgc cgcactggag acgctgtatg cagggacatg cggcagccaa
     7561 tctgatgccc gttgttgcgg caaaccggat cggggaggag acggtagaac cctgtgagga
     7621 aaacggcgga cagcgttcgg cgctcgtttt ttacggatcg tctttcctga ccgatgagac
     7681 cggagaaatt ctggcggagg cagggcgcga cgaggaagag atactggtgc aggaatatga
     7741 cctggacgag ctggatgcca gacggctgga gtgggggctg ttccgcgaca ggcgcccgga
     7801 gtgctacggc atcatcagcg gcaggtaaaa gaaatatatt gttgacatgg aaacaataat
     7861 gagatacagt aggaactggg aacaaaatac catgttagaa aaaggaagag tctgcatgaa
     7921 agatcgggaa gagctgttaa aagaaatcgc gctcatgctg gagcggcagg atatgctttc
     7981 caaactgacg gaaaaccagt gtctggatga atacggctat tcggagacac actgtatcga
     8041 ctatatcgga agactggaac tgccgaacgt cacgaaggtg gcggagcaca tggggatgac
     8101 gcgcggcgcg atcagcaaga tgaccaagaa gcttcttgcc aaagggctga tcgaaaaata
     8161 tacgctggag acgaacaaaa aggaagtata tttcaagctc acggatcagg gcaggctttt
     8221 gtttgatgag catgcgaagc gccataagcg atgggagaag cgcgatatgg aatttctggc
     8281 gcgctattcc gtcgaggatg tgaggacggt gagccgtttt atgacggagt tcaacggcta
     8341 tctggaagag cagatcgaga cgatcacagg gacgcaggca gaaggatgat attgtgtaat
     8401 aggaacgaag tttcctgtta cacaaaaaag aatcctgcag gcaggattct catgtgttac
     8461 tgttgtatga aatgtaattg ttaagcgttt aacacttcaa gaagcgtaag cagcttctct
     8521 accgtgtcct ggctgatgtt gtttgctgcg ataaaattgc ttaccgtcgt tgcaacatct
     8581 tcggaagtct ctgcagtgga tgcggatgcc acggtgttcg tatcgcttcc catataggag
     8641 agaaccttct ggacataatt ctgtgtctcg ctaaacggtg gaataccgcc gtatttatcg
     8701 acatttgcgc tgccggcgtt gtatgccgca agtgcaagag aggtatcacc gttgtacctg
     8761 gcaagcagct gggagatcag attcgcaccg cccatgatat tctggtaggc gtcgtaggaa
     8821 tctgtgacac cgagagatgc tgcggtggca ggcatcagct gcatgatacc gacggcaccg
     8881 gcgctgctga cagcgcttgt attaaaattg gattctgctc ttgcgattga ttttaaaaga
     8941 gtggaggaga cgccgtaggt gtttgccgcc tcgtcaaaga tggcggaaag gtcttcggag
     9001 caggccgtgc tgccggagta ggcgtcggtg gcattcgtta aaacggaaga aaagtcagat
     9061 cccgcagcct gtgctttggc agcttcggcg gcagctctct ccgcttcggc gcgggcagca
     9121 gcctcggtgt tgatctgatc cacaaatgcc tgatcgtgat aatttaagat cgtaatactc
     9181 attggtaact cccttgaaaa caacttcact gaatgtataa ctagaaaaag tatagcataa
     9241 tttacgggat taggaaagaa aaaaatgaaa accaagcaag ccgaacagaa agggacatat
     9301 ttacgtgcat tccgggcagc atttccctac acggtaccgg tgctcaccgg ctatctgttt
     9361 atcggaatgg cgttcggagt gatgatacag gaaaaaggtt acaacttctt gtgggcaatg
     9421 ctcatgagcc tggtgatcta tgcgggcagc ggacagtatc tggcagtcaa cttcttcgcg
     9481 ccgggcgtca gccttttcaa tgtgattttc atggaattta tggtgaatat ccgccatatt
     9541 ttttatggat tgtcactgtt ggaacgtttt tccgagatgg ggaaaaagcg gctctacatg
     9601 atcttttccc tgacggatga gacctactca cttttctttg tcacaaaagt gccgaaggat
     9661 gtgaaggagg agcagttctt atttgcgatt gccgtgcttg accagagtta ctggatcatc
     9721 ggctccggca tcggcgccct gcttggaaat gtacttccgt tctccgcgga gggcattgac
     9781 tttgcaatga cggcattgtt tgtggtaatc atggtagaac agtggatgga gaagcagaac
     9841 cgtccgagcg tggtgatcgg gctggtatgt ggactggtgt gcaggctggt gttcggagcg
     9901 gacaatttta tccttccgac catgatatgc gtcatggtca tcctgctttc ctgcaaaaaa
     9961 atattcgata aaatgattcc ggaggacgga aaggaaggag gcgagccgga gtgccagtaa
    10021 gtgttggaag atcgcttgcg atcatattta ccgtggcggg aacgatattt tttacccggc
    10081 tgattccgtt tctgtttttc ccgaaaggaa aagagattcc gccgatcatc cggtatctgg
    10141 ggagggtgct gcccccggcg gtcatcggaa tgctggtgat ctactgcctg aaaaatgtgt
    10201 cggtgcttgc agtacctttt ggtctgccgg aattcattgc cgtggcggcg gtcatcgtgc
    10261 ttcatgtatg gaagcgcaac aatctgctca gcattggtgt cggaacggca ctttatatgt
    10321 ttttgataca agttgtattc taggaagaga ggaagaaccg tatgaagaag aaaccatttg
    10381 taaccaaaga acagttagaa gaaatcgtaa aaaaataccc aacgccgttt catctctacg
    10441 atgaaaaagg aatccgcgaa aatgcgaagg cagtgaagga agcatttgca tggaacccgg
    10501 gattccggga gtattttgcg gtaaaggcaa cgccgaaccc gttcattctt gacattttaa
    10561 aagaatatga ctgcggatgt gactgtgcgt cgctgacaga gctgatgctt gcggattccc
    10621 agggcttcga tggaaaacac atcatgtttt cctccaatga tacgccggcg gaggaatttg
    10681 catttgccaa tgagcttggt gcgatcatca atctcgacga ttttacacac attgattttc
    10741 tggaaaaaac gatcggcagg attccggaga cgatcagctg ccggtacaat ccgggaggcg
    10801 tctttaagat gagcaacggc atcatggata atccgggcga tgcaaagtac ggttttaccc
    10861 acgagcagat cattgaggga ttcaagatct taaaggagaa gggagccaag cattttggcg
    10921 tacatgcgtt tcttgccagc aataccgtga caaacgaata ttacccgaag cttgcgagag
    10981 aactgtttga actggttgtg gaactgcgcg ataagacggg atgcgatatc cgttttatca
    11041 atctctccgg cggtgtcggt attccgtaca caccggatca gacgccgaac gacatccgtg
    11101 tcatcggaga gggcgtccgg gtggcatatg aggagatctt agttccggcg ggacttggcg
    11161 atgtcgcaat ctacacggag atgggacgtt ttatgctggg accgtacggc tgcctggtga
    11221 caacggccat ccatgagaag catacccaca aggagtacat cggtgtggac gcgtgtgccg
    11281 tgaacctgat gcgcccggca atttacgggg catatcacca tattacggtg atgggcaagg
    11341 aggatgcgcc gtgcgaccac aagtatgatg tgacaggctc actttgcgag aattgcgata
    11401 agtttgcgat tgaccggatg ctgccgaaga tcgacatggg agatcttctg gtgattcatg
    11461 ataccggtgc gcatggtttt tccatgggat acaactataa cggaaaatta aagtcagcgg
    11521 aggtgctgct gaaggaagac ggatcgacac agctgatccg tcgtgccgag acgccggagg
    11581 actatttccg cacgtttgac tgctttgata tcttaaagga tatgaagcac ccgaaataag
    11641 cggtagatca ttccggaaaa agcacagcag cgaggatgag atatgtgcat tgatacagaa
    11701 cgttttgagc gtgccagggg cagagtcatt ggaatcgagc ggcagaggct tggaatcggc
    11761 acactctcgg agaagacggt acatgcagtg ctcaagaatt attatgcacc ggatgaggat
    11821 atgcatgaga tcccgattga gaattttgtt gcggatattt ttgacgggga ggcagtgatc
    11881 gagattcaga cgcggtcgtt ccagaatatg cggcggaaac ttgccgcatt tctgccgttg
    11941 tacccggtga ccatcgtcta tccgattccg catgtgaagt ggcttcactg gatggatgag
    12001 gagacggggg agatctctcc cgggcgcaaa tcgcccaaga agggaaatgc ataccaggca
    12061 ttcatcgaat tgtataagat ccggccgttt ctgaaagatc cgaatctgag actacggctg
    12121 gatctcattg acatggagga ataccgtctg ttaaacggct ggagccggga caaaaagaag
    12181 ggaagcgacc gcttcgaccg gataccgctt accttcgtgg aggaagtgcg tgtggaccgg
    12241 agggaggact acatgcagtt catcccctat gagattccgg aggagtttac tgcgaaggat
    12301 tttgcggcat gcgcgaagat tccggtgcgg ctggcacaga cggtgctctt gattctgacg
    12361 gatctattga ttgtggagcg gattggaaag cagggaagaa gttatctcta ccggatctgc
    12421 gagattgaat gaatctcttc ccaagcgggg cgttctgtgt tatactgact gccggatgta
    12481 tatttatgca gtatctatgt gagagataag gaagcatgag gtagatagta cgatgaaaaa
    12541 cacagcaatc aaattatccg gcatactgct tgccggagcg gtcttttttt cgacgctgtt
    12601 agg
//
