LOCUS       gnlProkkaKAALHNMO_24   12988 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KAALHNMO_24.
ACCESSION   gnlProkkaKAALHNMO_24
VERSION     gnlProkkaKAALHNMO_24
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 12:00:14
            Original ID  :: gnl|Prokka|KAALHNMO_24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12988
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12988
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[387:3341]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      388..3341
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12988
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..12988
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     protocluster    1..11854
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[621:1854]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      622..1854
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     CDS             388..555
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_1"
                     /sec_met_domain="TIGR04404 (E-value: 1.5e-39, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
     CDS             622..1854
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     8.5e-17, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9e-24, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.6e-08, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.7e-07, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     CDS             1851..3341
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="skfc (E-value: 6.3e-291, bitscore: 955.3,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 3.1e-15, bitscore: 46.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQF
                     IKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKQYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL"
     CDS             3360..4079
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 178.6; E-value:
                     2.5e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg19_4"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGDINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVIETADRVILIRDGKLMQDLYVPQFEEQ
                     AEWRKEVIRLLGEWSDE"
     CDS             4144..5487
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MPFLIMLLFVGAIGFQVSFVSRSTTWDMSIAGWVLTGVFILYTAF
                     GLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFSVTWKALLWIISAIFGDVLIVLLSG
                     DHINLLGRSIIFVGLFFIAEVWLMSVSCARTVKKMKRVYVLVFLLMLGIYSICLYRFFF
                     LQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIGIITVSFMTIAFTSRQVEMKESLVK
                     EAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGIWSFLWLELLLFKKYLFFHSIHTVM
                     LSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSGIVRHSQSGTLHLFPGALWKKIIIL
                     ELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIYIWFMTIRLFAFTHTNRNDIKLSLP
                     QYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVCIGSLSWCLFYRFR"
     CDS             5534..6049
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     CDS             6054..6479
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     CDS             6726..7703
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="PF00561 (E-value: 1.9e-09, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGKG
                     TVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     CDS             7705..8376
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 126.9; E-value: 1.4e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     CDS             8373..9359
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE"
     CDS             9418..9681
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAVR
                     AKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD"
     CDS             complement(9666..10436)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 112.1;
                     E-value: 5.4e-34)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg19_12"
                     /sec_met_domain="Pkinase (E-value: 2.6e-34, bitscore:
                     108.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     CDS             complement(10522..11379)
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     CDS             11511..12695
                     /locus_tag="ctg19_14"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEAYKKYQ
                     AAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
ORIGIN
        1 aaccaaagtc attgctttct taatcactaa agtttatttg aaaataatct cttgatttaa
       61 tttcctcgaa gagatttttt gtcaatctat taggcatcag aatttttata acataatgga
      121 ccgtcttttt gacgttttgt ttatagaaca agaaaatatt caaaacataa gtggaaaatt
      181 aggggtgagc tcctgttttt ctcgagagga tagcttgtca gcttttctat ttttaaaggg
      241 ttaaaatatt ctatttatac taattaatgt aatttttagg ataatataca aaatccccct
      301 tacttcgaca attgcaatct ggtattatcg tatcgcatgg gagctatgtc aatagactct
      361 atgcaaaaat tgagaggagg tttacttatg aaaagaaacc aaaaagaatg ggaatctgtg
      421 agtaaaaaag gacttatgaa gccgggaggt acttcgattg tgaaagctgc tggctgcatg
      481 ggctgttggg cctcgaagag tattgctatg acacgtgttt gtgcacttcc gcatcctgct
      541 atgagagcta tttaacattt gagaataggg agttgagcgt atttgcttat actccttatt
      601 ttctcttaag ggggatttta tatgtcatat gatcgtgtta aagattttga tttgccagag
      661 ttagcggttc atttacagcc tcatggtgct gtaatgattg atagaaaaag tatgttttat
      721 ttcagactca gtggacgtgg agcacagttg gcgtttctgt tatcaaaaaa caaaaatctt
      781 cataaaacgg cacgtatttg ggagattatg aaaaaagaag agatgagtgc tgaccaatta
      841 aaagaagagc ttagtgccca tccatttacg gaggcttgga cggaagggct gttagatcag
      901 cctttacacg tttcgggttc gctagattca tatttaccta ttagttgtac cttacagttg
      961 acaaatgctt gtaatttaag ctgttcgttt tgctatgcca gctcaggtaa accatatcct
     1021 gaggaattat ctagtgaaca atggatattg gttatgcaaa agctagcagc ccatggagtt
     1081 gctgatatta cgctgaccgg gggtgaagca aagctgatca aagggtttaa agaattagtc
     1141 gttgttgcaa gttcgttgtt taccaatgtg aatgtattta gtaatggatt gaactggcga
     1201 gatgaagaag ttgaattact tagtcactta ggcaatgttt ctgtacagat tagtattgat
     1261 ggtatggata atacacatga ccaattaaga ggcagaaaag gcggctttaa agaaagtatg
     1321 aataccatta aaaaattatc agaagcaaac attccagtga ttgtcgctat gaccattaat
     1381 gagtccaatg ctgatgaagt atcagatgtg gtggagcaat gtgccaatgc gggtgctttt
     1441 atctttcgtg caggaaaaac gttatctgtt ggacgtgcga cagaaggctt taaggctttg
     1501 gatattgatt ttgaagaaat ggttcaaata cagcttaggg aagcacgtca taaatgggga
     1561 gatcgcctga acataattga ttgggagcac gaagagagtt cgttcacaac agatttttgt
     1621 acaccaggat atcttgcttg gtatataaga gcagatggat acgtaactcc ttgccaatta
     1681 gaagatttgc cgctagggca tattttagaa gatagcatgg ctgacattgg ttcacctgct
     1741 cgtttgcttc agttaaaatg tgaagcaaaa aattgcaaat gtatagggaa aattgagcta
     1801 tctgaaccgg acttaccttt tcaaaaagaa gtcaaggcag ggattcagga atgaatagtc
     1861 tatcattggt gttctggagt attttagcag ttgttggatt actgttattt attaaattca
     1921 aacccccaac aattgcttca ctactcttaa gcaaagatga ggcaaaagaa ataagcattc
     1981 aatttataaa agagtttgtt gggatagatg tagagaactg ggatttttat tcagtatatt
     2041 ggtatgacca cgatacagta aataaacttc atcacttagg catacttaag aaaaatagaa
     2101 aggttttata tgatgttggg ttggtcgaat catggagagt ccgtttcgtt caccagaatc
     2161 aatcatttgt agttggtgtc aatgccaatc gagaaatcac ttttttttat gcggatgttc
     2221 cgaaaaaaac cctttcgggg aagtttgaac aagtttctcc agagacactc aagcagaggt
     2281 taatggcttc acctgatgga ctttggtcta gagcaaatat gactggtact ggtaaaaaag
     2341 aggaggattt tcgcgaggtc agtacttatt ggtacatagc ggaagcggga gatattcggc
     2401 tcaaagtgac tgttgaatta cagggcggcc gaatttctta tattggtact gaacaagaaa
     2461 tactaacaga tcaaatgagt aaagtcattc gagatgaaca agtggaatcg acattcggag
     2521 tatctggtat gctgggttca gctttagcga tgatccttgc gattctcatc cttgtattta
     2581 tggatgtgca aacaagcata atcttcagtc ttgttctggg tttgttgatt ataatatgcc
     2641 agtcattgac gctgaaagaa gatattcaat taacaattgt aaatgcttat gatgcaagaa
     2701 tgagtgtcaa aacggtcagt ttattaggta ttttgtctac acttcttaca ggattattaa
     2761 caggatttgt agtatttata tgttcattgg caggaaatgc gcttgctggt gattttggat
     2821 ggaaaacgtt tgaacaacca atagttcaga ttttctatgg aataggagca gggctcatta
     2881 gtttaggagt gacttctctg ctgtttaact tattggagaa aaagcaatat ttacgaattt
     2941 cacctgagct ttctaaccga actgtctttc tatcaggttt tacctttagg caaggattga
     3001 atatgagcat acaaagttca attggagaag aggtcatcta tcggctatta atgattccag
     3061 tcatttggtg gatgagtgga aatatcctca tctccattat tgtatcttcc tttttatggg
     3121 cggtgatgca ccaagtaact ggatatgacc caaggtggat acgttggctg catctattta
     3181 tattcggttg ctttctggga gttctcttca tcaaatttgg ttttatttgt gtattagtag
     3241 ctcatttcat tcataattta gtactcgtct gtatgccgct gtggcagttc aagcttcaga
     3301 aacatatgca tcatgatcag ccaaagcata cttcactcta atgattagga gaagatttga
     3361 tgcaattgat gcaagtacaa aatttaagca aatgctatcg aaatggtgat ggggttgaac
     3421 atttgtcttt ctcaattcaa cgaggagaaa tcgtggcgct attggggcca aatggagctg
     3481 gaaaaacaac gacaattcga tgtttgacag gtctctataa gccggataaa ggagatatcc
     3541 tcattgaggg ttctcctcca ggagatataa atgttcaaaa aaaagtcgcg cttattcctg
     3601 atcagccata tttgtatccc gctttaactg ctgctgaaca tattcagttt agggcaagag
     3661 gatatcatcc aggtaaaaaa gatgtaaaag aaagggttta tcatgcattg aaggaagtgc
     3721 acttggagga gaaagcaaac caattgtgtg gtcagctgtc aagaggccaa aagcagcggg
     3781 ttgtcctggc gggggcgatt gttcaagacg ctttgctgta tatattagac gaaccgactg
     3841 tgggccttga tatcccatca aaacagtggc tctctaactg gttaaaaact aaaaccgatc
     3901 aagggtgttc agcatttgta tcaactcata gtctagagtt tgttatagag acagcagaca
     3961 gggtgatatt aattagagac ggcaaactca tgcaggattt gtatgttcct caattcgaag
     4021 aacaagcgga atggagaaaa gaagtgattc gtcttctagg ggaatggtca gatgaataat
     4081 atcatttctt ttttatggct tcagtcaaaa aggcgttttg taagtcaagg tcaggaaaaa
     4141 aaaatgcctt ttttgatcat gctccttttt gttggggcca tcggatttca agtaagtttt
     4201 gtttctagat ctacgacatg ggatatgagt attgctggtt gggtacttac aggtgttttt
     4261 atcctttata cggcatttgg acttttttca aatcgattac caagtcaaat ggcagatatt
     4321 atatggcttt atggcactgc cacatctttt tcaaaagttg tgtatagtgt tttatttttc
     4381 agcgtcactt ggaaggcgtt gctttggatc atctcagcca tattcggtga tgtattaatt
     4441 gtgcttctgt ctggtgatca tatcaattta ttaggccgat ccataatttt tgtagggctc
     4501 ttttttatcg ctgaagtgtg gttgatgtcg gtctcttgtg ccagaacagt gaagaaaatg
     4561 aaaagggtat acgttttagt ctttcttcta atgttaggca tttactccat atgtctttat
     4621 cgcttcttct ttctccaaca ttcatctggg atatgggaga gcattgcccg ttttattagt
     4681 ggcgttggat tagtgtttga tacattgtca ccgttgtatg tggttgtatt tattgggatt
     4741 atcacagtct cttttatgac aattgctttt acgagccgtc aggtagaaat gaaggaatcg
     4801 ttggtgaaag aagctgaatt ctgggaggaa tttcaagaac gtcaatttgg ttcaggtcaa
     4861 attatacaga aaccaaaaac gacttggtgg ggcttgcaag gtctaaatgg catttggtct
     4921 tttctgtggt tggaactgtt gctttttaaa aaatatttat tttttcatag cattcatacg
     4981 gtcatgctca gtggcgtctt ttatgtcgtc attttcatgt atccagaatg gttttatctt
     5041 ctattctttc ttatcgtctc ggcagtcatg ttaagttcct attattcagg aattgtcaga
     5101 cattctcaat caggcaccct tcatttattc cccggtgccc tttggaaaaa aatcattatt
     5161 ctagagctga cgaatacagt ctggttgtat attctttact gtgtttctat tacttttatg
     5221 gcagttggga atttagttta ttggtatata tatggcttag ggatatatat atggttcatg
     5281 acaataaggc tttttgcttt tacccataca aaccgaaacg atattaagct ttcattgcct
     5341 caatactaca agtcattttt tatggcatta ggcctgagcg gcatttgttt gtatgtcatt
     5401 catttattga ctgctgactg gtatacatta gtggtggtcg tctgcatagg gagcctaagt
     5461 tggtgcctgt tttatcgttt cagatagtgg ttatgtagag ttattgtttt aaaacgagga
     5521 gaggggctct tttatgaatt caaatggtga taaattgtcg ttatctgttc agaatttagc
     5581 gaatacaaat gagatcacaa ttgttcaagc gataggtgag ctaaagaaat cgggaaaaga
     5641 tgcaatacca gttttggttg aggccttaaa agaggaaggc tctttgtgta atattgctgc
     5701 agctgtttta ggtgagtttg gggaagacgc gagtgaagca gcggaggagc tatcatgttt
     5761 attaaaaagt catgcggaag atacaagaat ggcagcggcg atttcattaa tgagaatcgg
     5821 gaagcccagt ctgccctttg tcatcaaaat cgctcaagaa agtgaagggc aatcgtgctt
     5881 ttgggcatct tggtgtattg catggattga tccgtcttgc attgaaccta agatgtataa
     5941 atgtctaaaa tacgagcatg aacatccttc aggaatagtt gctccgtttg cggctgaaga
     6001 ggcattagga aagctgattg cttttcagct gaaagataag gaggactgaa aggatgaaag
     6061 atgaacaaat gttgactgaa tggccaagtc atttaccatg gttgaatcaa tcacagaatg
     6121 attttacatt tccaagtgac acatatcttc ttctttattt ttggtcaatg agctgtccaa
     6181 actgtcacca attaacagac aaagtccttc aagatataaa ggatatgaat gtgaaagtaa
     6241 tcggagtaca tgtcccctat atagaagaag agaaatctat ggaggttgtc ttgacgtatg
     6301 ctcttgatag gggactagct attccgattg tattagacca aaactatgag atcgtcacaa
     6361 cttgtcacgt acaaggcatc cccagctttt gtctattaag tcaatacggt cagatcatta
     6421 ctaaaacgat gggagatgtt ggttgggata agatgttaaa aaagattgca ggcttgtgaa
     6481 attttccgtc ttgtatgtgc gacaaacggt tgaatattat gatgaaacgg tccttcctat
     6541 aagcaggaag gttttttaat gaaatatttt tttattagta ggtaaattca tcaaatgttc
     6601 tgctatgctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt
     6661 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc
     6721 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg
     6781 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg
     6841 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc
     6901 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg
     6961 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag
     7021 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat
     7081 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc
     7141 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca
     7201 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg
     7261 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt
     7321 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag
     7381 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg
     7441 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa
     7501 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac
     7561 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac
     7621 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg
     7681 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat
     7741 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg
     7801 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat
     7861 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg
     7921 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg
     7981 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg
     8041 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat
     8101 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt
     8161 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat
     8221 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt
     8281 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga
     8341 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt
     8401 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt
     8461 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt
     8521 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat
     8581 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc
     8641 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg
     8701 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc
     8761 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata
     8821 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg
     8881 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca
     8941 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa
     9001 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg
     9061 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg
     9121 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg
     9181 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga
     9241 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga
     9301 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac
     9361 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg
     9421 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg
     9481 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca
     9541 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac
     9601 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg
     9661 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc
     9721 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt
     9781 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc
     9841 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc
     9901 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca
     9961 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg
    10021 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc
    10081 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa
    10141 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg
    10201 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt
    10261 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa
    10321 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata
    10381 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct
    10441 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc
    10501 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt
    10561 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca
    10621 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct
    10681 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt
    10741 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg
    10801 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct
    10861 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga
    10921 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga
    10981 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga
    11041 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc
    11101 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt
    11161 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt
    11221 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt
    11281 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga
    11341 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt
    11401 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat
    11461 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga
    11521 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg
    11581 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc
    11641 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt
    11701 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag
    11761 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca
    11821 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg
    11881 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg
    11941 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag
    12001 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg
    12061 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag
    12121 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca
    12181 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa
    12241 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa
    12301 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc
    12361 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt
    12421 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc
    12481 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa
    12541 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg
    12601 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg
    12661 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt
    12721 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt
    12781 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg
    12841 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat
    12901 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag
    12961 caggtctgct gttttctcat ttatgagt
//
