LOCUS       gnlProkkaMLEOMEED_6    12924 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLEOMEED_6.
ACCESSION   gnlProkkaMLEOMEED_6
VERSION     gnlProkkaMLEOMEED_6
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:07:46
            Original ID  :: gnl|Prokka|MLEOMEED_6
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12924
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12924
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[291:3245]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      292..3245
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12924
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..12924
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     protocluster    1..11758
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[525:1758]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      526..1758
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     CDS             2..148
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MTFYKIIDRLFDVLFIEQENIQNISGKLGVSSCFSREDSLSAFLF
                     LKG"
     CDS             292..459
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2"
                     /sec_met_domain="TIGR04404 (E-value: 1.6e-39, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
     CDS             526..1758
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_3"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     9.1e-17, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.6e-24, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-08, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.8e-07, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     CDS             1755..3245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_4"
                     /sec_met_domain="skfc (E-value: 6.8e-291, bitscore: 955.3,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 3.3e-15, bitscore: 46.4,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQF
                     IKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIICQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKQYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVLVCMPLWQFKLQKHMHHDQPKHTSL"
     CDS             3264..3983
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 178.6; E-value:
                     2.5e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_5"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGDINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQGCSAFVSTHSLEFVIETADRVILIRDGKLMQDLYVPQFEEQ
                     AEWRKEVIRLLGEWSDE"
     CDS             4048..5391
                     /locus_tag="ctg5_6"
                     /transl_table=11
                     /translation="MPFLIMLLFVGAIGFQVSFVSRSTTWDMSIAGWVLTGVFILYTAF
                     GLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFSVTWKALLWIISAIFGDVLIVLLSG
                     DHINLLGRSIIFVGLFFIAEVWLMSVSCARTVKKMKRVYVLVFLLMLGIYSICLYRFFF
                     LQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIGIITVSFMTIAFTSRQVEMKESLVK
                     EAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGIWSFLWLELLLFKKYLFFHSIHTVM
                     LSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSGIVRHSQSGTLHLFPGALWKKIIIL
                     ELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIYIWFMTIRLFAFTHTNRNDIKLSLP
                     QYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVCIGSLSWCLFYRFR"
     CDS             5438..5953
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     CDS             5958..6383
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     CDS             6630..7607
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_9"
                     /sec_met_domain="PF00561 (E-value: 2e-09, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGKG
                     TVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     CDS             7609..8280
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 126.9; E-value: 1.4e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     CDS             8277..9263
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE"
     CDS             9322..9585
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAVR
                     AKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD"
     CDS             complement(9570..10340)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 112.1;
                     E-value: 5.4e-34)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg5_13"
                     /sec_met_domain="Pkinase (E-value: 2.8e-34, bitscore:
                     108.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     CDS             complement(10426..11283)
                     /locus_tag="ctg5_14"
                     /transl_table=11
                     /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     CDS             11415..12599
                     /locus_tag="ctg5_15"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEAYKKYQ
                     AAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
ORIGIN
        1 tcagactttt tataaaataa tagaccgtct ttttgacgtt ttgtttatag aacaagaaaa
       61 tattcaaaac ataagtggaa aattaggggt gagctcctgt ttttctcgag aggatagctt
      121 gtcagctttt ctatttttaa agggttaaaa tattctattt atactaatta atgtaatttt
      181 taggataata tacaaaatcc cccttacttc gacaattgca atctggtatt atcgtatcgc
      241 atgggagcta tgtcaataga ctctatgcaa aaattgagag gaggtttact tatgaaaaga
      301 aaccaaaaag aatgggaatc tgtgagtaaa aaaggactta tgaagccggg aggtacttcg
      361 attgtgaaag ctgctggctg catgggctgt tgggcctcga agagtattgc tatgacacgt
      421 gtttgtgcac ttccgcatcc tgctatgaga gctatttaac atttgagaat agggagttga
      481 gcgtatttgc ttatactcct tattttctct taagggggat tttatatgtc atatgatcgt
      541 gttaaagatt ttgatttgcc agagttagcg gttcatttac agcctcatgg tgctgtaatg
      601 attgatagaa aaagtatgtt ttatttcaga ctcagtggac gtggagcaca gttggcgttt
      661 ctgttatcaa aaaacaaaaa tcttcataaa acggcacgta tttgggagat tatgaaaaaa
      721 gaagagatga gtgctgacca attaaaagaa gagcttagtg cccatccatt tacggaggct
      781 tggacggaag ggctgttaga tcagccttta cacgtttcgg gttcgctaga ttcatattta
      841 cctattagtt gtaccttaca gttgacaaat gcttgtaatt taagctgttc gttttgctat
      901 gccagctcag gtaaaccata tcctgaggaa ttatctagtg aacaatggat attggttatg
      961 caaaagctag cagcccatgg agttgctgat attacgctga ccgggggtga agcaaagctg
     1021 atcaaagggt ttaaagaatt agtcgttgtt gcaagttcgt tgtttaccaa tgtgaatgta
     1081 tttagtaatg gattgaactg gcgagatgaa gaagttgaat tacttagtca cttaggcaat
     1141 gtttctgtac agattagtat tgatggtatg gataatacac atgaccaatt aagaggcaga
     1201 aaaggcggct ttaaagaaag tatgaatacc attaaaaaat tatcagaagc aaacattcca
     1261 gtgattgtcg ctatgaccat taatgagtcc aatgctgatg aagtatcaga tgtggtggag
     1321 caatgtgcca atgcgggtgc ttttatcttt cgtgcaggaa aaacgttatc tgttggacgt
     1381 gcgacagaag gctttaaggc tttggatatt gattttgaag aaatggttca aatacagctt
     1441 agggaagcac gtcataaatg gggagatcgc ctgaacataa ttgattggga gcacgaagag
     1501 agttcgttca caacagattt ttgtacacca ggatatcttg cttggtatat aagagcagat
     1561 ggatacgtaa ctccttgcca attagaagat ttgccgctag ggcatatttt agaagatagc
     1621 atggctgaca ttggttcacc tgctcgtttg cttcagttaa aatgtgaagc aaaaaattgc
     1681 aaatgtatag ggaaaattga gctatctgaa ccggacttac cttttcaaaa agaagtcaag
     1741 gcagggattc aggaatgaat agtctatcat tggtgttctg gagtatttta gcagttgttg
     1801 gattactgtt atttattaaa ttcaaacccc caacaattgc ttcactactc ttaagcaaag
     1861 atgaggcaaa agaaataagc attcaattta taaaagagtt tgttgggata gatgtagaga
     1921 actgggattt ttattcagta tattggtatg accacgatac agtaaataaa cttcatcact
     1981 taggcatact taagaaaaat agaaaggttt tatatgatgt tgggttggtc gaatcatgga
     2041 gagtccgttt cgttcaccag aatcaatcat ttgtagttgg tgtcaatgcc aatcgagaaa
     2101 tcactttttt ttatgcggat gttccgaaaa aaaccctttc ggggaagttt gaacaagttt
     2161 ctccagagac actcaagcag aggttaatgg cttcacctga tggactttgg tctagagcaa
     2221 atatgactgg tactggtaaa aaagaggagg attttcgcga ggtcagtact tattggtaca
     2281 tagcggaagc gggagatatt cggctcaaag tgactgttga attacagggc ggccgaattt
     2341 cttatattgg tactgaacaa gaaatactaa cagatcaaat gagtaaagtc attcgagatg
     2401 aacaagtgga atcgacattc ggagtatctg gtatgctggg ttcagcttta gcgatgatcc
     2461 ttgcgattct catccttgta tttatggatg tgcaaacaag cataatcttc agtcttgttc
     2521 tgggtttgtt gattataata tgccagtcat tgacgctgaa agaagatatt caattaacaa
     2581 ttgtaaatgc ttatgatgca agaatgagtg tcaaaacggt cagtttatta ggtattttgt
     2641 ctacacttct tacaggatta ttaacaggat ttgtagtatt tatatgttca ttggcaggaa
     2701 atgcgcttgc tggtgatttt ggatggaaaa cgtttgaaca accaatagtt cagattttct
     2761 atggaatagg agcagggctc attagtttag gagtgacttc tctgctgttt aacttattgg
     2821 agaaaaagca atatttacga atttcacctg agctttctaa ccgaactgtc tttctatcag
     2881 gttttacctt taggcaagga ttgaatatga gcatacaaag ttcaattgga gaagaggtca
     2941 tctatcggct attaatgatt ccagtcattt ggtggatgag tggaaatatc ctcatctcca
     3001 ttattgtatc ttccttttta tgggcggtga tgcaccaagt aactggatat gacccaaggt
     3061 ggatacgttg gctgcatcta tttatattcg gttgctttct gggagttctc ttcatcaaat
     3121 ttggttttat ttgtgtatta gtagctcatt tcattcataa tttagtactc gtctgtatgc
     3181 cgctgtggca gttcaagctt cagaaacata tgcatcatga tcagccaaag catacttcac
     3241 tctaatgatt aggagaagat ttgatgcaat tgatgcaagt acaaaattta agcaaatgct
     3301 atcgaaatgg tgatggggtt gaacatttgt ctttctcaat tcaacgagga gaaatcgtgg
     3361 cgctattggg gccaaatgga gctggaaaaa caacgacaat tcgatgtttg acaggtctct
     3421 ataagccgga taaaggagat atcctcattg agggttctcc tccaggagat ataaatgttc
     3481 aaaaaaaagt cgcgcttatt cctgatcagc catatttgta tcccgcttta actgctgctg
     3541 aacatattca gtttagggca agaggatatc atccaggtaa aaaagatgta aaagaaaggg
     3601 tttatcatgc attgaaggaa gtgcacttgg aggagaaagc aaaccaattg tgtggtcagc
     3661 tgtcaagagg ccaaaagcag cgggttgtcc tggcgggggc gattgttcaa gacgctttgc
     3721 tgtatatatt agacgaaccg actgtgggcc ttgatatccc atcaaaacag tggctctcta
     3781 actggttaaa aactaaaacc gatcaagggt gttcagcatt tgtatcaact catagtctag
     3841 agtttgttat agagacagca gacagggtga tattaattag agacggcaaa ctcatgcagg
     3901 atttgtatgt tcctcaattc gaagaacaag cggaatggag aaaagaagtg attcgtcttc
     3961 taggggaatg gtcagatgaa taatatcatt tcttttttat ggcttcagtc aaaaaggcgt
     4021 tttgtaagtc aaggtcagga aaaaaaaatg ccttttttga tcatgctcct ttttgttggg
     4081 gccatcggat ttcaagtaag ttttgtttct agatctacga catgggatat gagtattgct
     4141 ggttgggtac ttacaggtgt ttttatcctt tatacggcat ttggactttt ttcaaatcga
     4201 ttaccaagtc aaatggcaga tattatatgg ctttatggca ctgccacatc tttttcaaaa
     4261 gttgtgtata gtgttttatt tttcagcgtc acttggaagg cgttgctttg gatcatctca
     4321 gccatattcg gtgatgtatt aattgtgctt ctgtctggtg atcatatcaa tttattaggc
     4381 cgatccataa tttttgtagg gctctttttt atcgctgaag tgtggttgat gtcggtctct
     4441 tgtgccagaa cagtgaagaa aatgaaaagg gtatacgttt tagtctttct tctaatgtta
     4501 ggcatttact ccatatgtct ttatcgcttc ttctttctcc aacattcatc tgggatatgg
     4561 gagagcattg cccgttttat tagtggcgtt ggattagtgt ttgatacatt gtcaccgttg
     4621 tatgtggttg tatttattgg gattatcaca gtctctttta tgacaattgc ttttacgagc
     4681 cgtcaggtag aaatgaagga atcgttggtg aaagaagctg aattctggga ggaatttcaa
     4741 gaacgtcaat ttggttcagg tcaaattata cagaaaccaa aaacgacttg gtggggcttg
     4801 caaggtctaa atggcatttg gtcttttctg tggttggaac tgttgctttt taaaaaatat
     4861 ttattttttc atagcattca tacggtcatg ctcagtggcg tcttttatgt cgtcattttc
     4921 atgtatccag aatggtttta tcttctattc tttcttatcg tctcggcagt catgttaagt
     4981 tcctattatt caggaattgt cagacattct caatcaggca cccttcattt attccccggt
     5041 gccctttgga aaaaaatcat tattctagag ctgacgaata cagtctggtt gtatattctt
     5101 tactgtgttt ctattacttt tatggcagtt gggaatttag tttattggta tatatatggc
     5161 ttagggatat atatatggtt catgacaata aggctttttg cttttaccca tacaaaccga
     5221 aacgatatta agctttcatt gcctcaatac tacaagtcat tttttatggc attaggcctg
     5281 agcggcattt gtttgtatgt cattcattta ttgactgctg actggtatac attagtggtg
     5341 gtcgtctgca tagggagcct aagttggtgc ctgttttatc gtttcagata gtggttatgt
     5401 agagttattg ttttaaaacg aggagagggg ctcttttatg aattcaaatg gtgataaatt
     5461 gtcgttatct gttcagaatt tagcgaatac aaatgagatc acaattgttc aagcgatagg
     5521 tgagctaaag aaatcgggaa aagatgcaat accagttttg gttgaggcct taaaagagga
     5581 aggctctttg tgtaatattg ctgcagctgt tttaggtgag tttggggaag acgcgagtga
     5641 agcagcggag gagctatcat gtttattaaa aagtcatgcg gaagatacaa gaatggcagc
     5701 ggcgatttca ttaatgagaa tcgggaagcc cagtctgccc tttgtcatca aaatcgctca
     5761 agaaagtgaa gggcaatcgt gcttttgggc atcttggtgt attgcatgga ttgatccgtc
     5821 ttgcattgaa cctaagatgt ataaatgtct aaaatacgag catgaacatc cttcaggaat
     5881 agttgctccg tttgcggctg aagaggcatt aggaaagctg attgcttttc agctgaaaga
     5941 taaggaggac tgaaaggatg aaagatgaac aaatgttgac tgaatggcca agtcatttac
     6001 catggttgaa tcaatcacag aatgatttta catttccaag tgacacatat cttcttcttt
     6061 atttttggtc aatgagctgt ccaaactgtc accaattaac agacaaagtc cttcaagata
     6121 taaaggatat gaatgtgaaa gtaatcggag tacatgtccc ctatatagaa gaagagaaat
     6181 ctatggaggt tgtcttgacg tatgctcttg ataggggact agctattccg attgtattag
     6241 accaaaacta tgagatcgtc acaacttgtc acgtacaagg catccccagc ttttgtctat
     6301 taagtcaata cggtcagatc attactaaaa cgatgggaga tgttggttgg gataagatgt
     6361 taaaaaagat tgcaggcttg tgaaattttc cgtcttgtat gtgcgacaaa cggttgaata
     6421 ttatgatgaa acggtccttc ctataagcag gaaggttttt taatgaaata tttttttatt
     6481 agtaggtaaa ttcatcaaat gttctgctat gctccaaatg tacacctttc cgtaagggca
     6541 aagtcaaatg tgaaaaaaaa ctgttccaaa gttaatcaga aatttatttt catattgtat
     6601 ccttcggtat caagtgaaag gagcatcata tgaaaacatt atggaaagtc ctcaaaattg
     6661 tttttgtcag cttggctgct ttggttttgc ttgtatccgt ctcggtattt atttatcacc
     6721 atttccagct aaataaggag gcggcactgc tgaaaggtaa aggcacagta gtcgatgttg
     6781 acggtaaaaa gatgaatgtg tatcaagagg gaagcgggaa ggatacgttt gtgtttatgt
     6841 ccggttcggg tattgctgcg cctgcttatg aaatgaaggg gctgtacagc aagttttcaa
     6901 aagaaaataa gattgctgtt gtagatcggg caggttatgg atacagtgaa gtgtctcacg
     6961 atgacagaga tattgatacg gtattggaac agacgaggaa agcgcttatg aaaagcggaa
     7021 ataagcctcc ttatatttta atgcctcatt cgatatccgg gattgaagcg atgtattggg
     7081 cacagaaata tcctaaggaa atcaaggcca ttattgcgat ggatattgga ttgccccagc
     7141 agtacgtcac gtataaattg agcggagttg accgattgaa agtgagaggg ttccacctgt
     7201 taacctcgat tggttttcat cggtttatac cttccgctgt atataatcct gaggtgattc
     7261 gacagtcgtt tttaactgat gaagaaaaag aaatctataa agccattaac tttaagcaat
     7321 tttttaatgc agatatggag catgagcttt tacagtctta ccaaaacggc agcaaatctg
     7381 tgaatctgcc tgcgccaaag gaaactcccg tcttgatttt agatgcagtc tctgaccaaa
     7441 atagacattc aaagtatgct atacaaaacc gaaaagacta tgaagcgttt gcggctcaat
     7501 tcaatactgc cgatataaag gaactgaggg gaacacacag tatttattta tatcagcctg
     7561 atcaaatata taaactgtcc atggagttta tgagaaaggt tcgctaggat gaagggttat
     7621 cgtattttaa tcgttgagga cgatgtgatg attggtgatt tgctgcaaaa gattttgcag
     7681 cgcgagggat atcgtgtgat atggaaaaca gatggagcgg atgtgctttc ggtgattcag
     7741 aaggtggatt tggtcattat ggatgtgatg ctgccgggtg aagacgggta tcaaatgtct
     7801 gcaaaaatca aaaagctggg gctgggcatt ccggttattt ttctctcagc ccgcaatgac
     7861 atggacagca agcttcaagg tttgcagatc ggcgaggatt atatggtaaa gccctttgat
     7921 ccgagagagc tgctattaag aatgcggaat atgcttgagc atcattatgg gacctttacg
     7981 caaatcaaac atttgtatat tgatgcggta acgaaaaaag tgttcaatga aagcctgcat
     8041 gatgaggtat tatttactgc gattgagcgg aaaattttct tttatttata tgaaaataga
     8101 gacagtatcc tgacaaagga acatttcttt gaatatctat ggcagctcga agatagaaac
     8161 ccgaatattg tcaatgtgca tattaaaaaa attagagcta aaatcaatga tcaagcgggt
     8221 gagatgattg aaaatatata tggagaaggg tatcggctga ataccgttgt gaagaaatga
     8281 agctcaagac aaaatatcag ttgttattgt ttacggccgt cattagtgtt ccgatgctat
     8341 tgctggcggt cagtgttttg atgtcggtga tttatgacag catgtttaaa ccgatgaatc
     8401 atggtatgcc ctttcacagg tcgtttgcat acccggcaat gatcgttgta tttttgatat
     8461 cactcttatt gttagctttt ttattttcaa agtcgattca ttctctgttg cataaaatca
     8521 atctattaaa tcaaaccatt cggcatttgg cgagtgatca aagggtgccc gataaaattg
     8581 aagtgaagcg tgctgatgaa atcggggaac tgatcaagtc ggtcaatttg ttaattgaac
     8641 ggacgacata tcgtgaactg gagctgagac agcaggagga aatcaaaaag gagcttttgc
     8701 aaaaactgcg gcatgacatt aatacacctt taacggctct caggctgcag ttattttatt
     8761 tggaagacca atgtcatggt caggctgtat tcgaatcatt gtatcagcaa atcgaatata
     8821 tctcggaatt aactaatgaa ttcaatctat attccgctga gacgctggaa agctcttata
     8881 ttgtaaatga agaagtgcgt ctaaacgagc tattagaaac agcggtgaaa aagtgggatt
     8941 atttatacag tatgagtggg attgagctgc actataagcc ggcagatcaa gatgtgatat
     9001 ggatgagcaa cacgttatgg atggaaaggc tgtttgataa tatttttcaa aatacgttaa
     9061 ggcattcaaa agctaaaaag atggaagtca cgattgaaca tggcgatgtt tttattcgtg
     9121 atgacggtat tggatttgat cggaatgaga gcagtgaggg acttgggtta aagattattg
     9181 aggatacatg caggctgctt gcgattactt atgagctgca tacaaatgat aacggaacgg
     9241 ggttcttgtt ttcaaaagag tgaccccgct gatgtttttc tttctcctat aaaatttata
     9301 taatagggag aaagaaatgg ggtgaacatc atatgtttaa aaaaatcatc aaaacgatta
     9361 agtacctctc aagcagttct agtgaccgat atcgcagaca ccggcattac agcagcagcc
     9421 ggcgcagaca ttatcgcagc tacagcagca gttcgggcaa aagaagacac tacgaccgtt
     9481 atggcggcag tcatcgttac aaacgccgga gctacagcag cagttaatcc aaaaaaagtt
     9541 cttgttccgc ttttgggaca agggtttttt tatgtgaccg attgaatggc ccggtttaga
     9601 tcctcgcgaa tggaagcggt gtgctgatac tcttcctcaa tgcccaataa tcttttcagc
     9661 agcaaggtta cttcctttgt cagtgttaat tcctccagcc aagtgccgtt tttcttcttt
     9721 tttcctttat attgagagta cagcaagaat aacagcgttt ctccgagatc gaagaagtca
     9781 tcctgttttc gtacctttat ttcctccatt tcttcaggag tcaattgttt ggcaaggccg
     9841 aaatcgatga ggcagagcct gccatcattg atgatgatat taggcgttct gatgtcgctg
     9901 tggaagataa ggcgatcatg caggtattct ataatctcaa gcagctgcga aatcagttgt
     9961 aacgccataa gctctgtgaa cggctgtttt cgaaaaaata ataattcttc tatattctct
    10021 ccctcaatga actgcatgac ataataagcc tgtccgtcta tgatgaattc atctatgaag
    10081 cccggaattt gcgggtggtg aatgtttttg agcagtttta tttcctgctg gaatcggact
    10141 ttctcttttt cctttttggc ttttgtcggc cgaagctgtt ttaagacata aggtgtttga
    10201 gctaggatat cggtgcacaa ataaaccaaa ccgtagcctc ccataccgag gcactcttcg
    10261 attttgtatt gatgatttaa gataacgccg ttctttagag ggcggtcaaa tagcagtttt
    10321 tttagaagtt ttaatgccat gtctgcactt cccttggttg tactgactat agtttacctt
    10381 ctagacggag aataaaaaag agccggataa ccggctcggt ataagttaaa actgctttgt
    10441 cacgtcgtat tcataatcta tttttgcttt tacgttgctc atcgtcgatc tggctgtcgc
    10501 taatgtatta tatttaaaac tccatacctt tgccacactg agttgatccg acaaagagat
    10561 atcataagac cctgaagtcg agctgtttac aagggcacgg ctccattcgt tattttcgct
    10621 tgtcatgatc agatggcgtg tatttccctg gcttggtgtt tgagtggcgg ttgtttgaac
    10681 tctggttaca atggcatcac gcggtatccc agattggttt gttaaatcaa ccttgatcac
    10741 gctggagtca gaacctgagg ggctaaggct tgtatttcct ttattttcag caacgccgct
    10801 gaattggaac gttccgctgc ctgatttgat tcggtcttca attgaaagcg taaagtacat
    10861 gtttccagta taggtgcctc gtgacacttt cacatagaag gtatccgtcg tgttttgggc
    10921 gtctgcattt gcataaataa aagaagaaaa cgtattaggg ttaataactt ctgtcccttg
    10981 agaaacaggt attctgttct tgtcataaat ttcaattttc atccctgtat acgcgctctg
    11041 gtatgtactc ctcatgtata ctttttctcc cttattagcc gtaaaagtga aataggcttc
    11101 atcttgacca gcttccagta ttgttgtatc gatattttta tatttccaat aaccgatcgg
    11161 cattgcggta tcaaatgaat tgtttcctgt gatagcagtg actccgacag ctgatgccga
    11221 atacgtaaag gtagataaga cagaaagcat aacagcgaat tgaataagcc attttttcac
    11281 catgcaaaca acctcctttt atttccatca tacataataa cgatttaggt gtaaataaat
    11341 gttttttgag gttaatatat acattatatt cgccgataaa aaagaataag agagaatact
    11401 cgggagggaa ttcaatgcgt ctgaatcggc aatttatccg cactcagctg attgcacaga
    11461 acatattgag caagaatgcg cctgccaaac gggagaatgc gactgaaaat ccagcggcag
    11521 ttctggaaaa ggcatatagc aggcttaagt cacaatcttc aactggggga atcaatcagt
    11581 tcaattattc taaaaccagc gtgtcgggaa acagcgggac gttcagcaaa gtgtatcaat
    11641 cagcgaatga tcgaacagtg acagacacag gggaagaaac agtgattcaa tcccaaaacc
    11701 cctatgaatc tgagagtgat atcagaatca aaatactaga tgaaaaatac agcaggatga
    11761 atgcgattaa taaaacaaag tctgatccat taggctatat taaggataag taccaaaatt
    11821 caaagtctcc ttatttcaga agtgatctgt cagctgcaga aagacaggcc gcttacgata
    11881 atgaaacaga atggttattc aaagggaagg cgcaaaacta taaccttcag gatgctgtgt
    11941 ttcggaatgt cacatttcat ggggaagtgg aagctgagaa tgaaaaggtg tatcagcggg
    12001 gacaggttaa ccagcagctg caagtactgt tgaatcgaaa ccatattcat attccagagg
    12061 ggacagagct gacgtttaca atcacaccga ttgactatca ggtgcgggta agcgggacag
    12121 acgatcagga tctgatcaag caaattgagc aagtgctgca atctggagac aacagcaaag
    12181 aactattttt acacatcatg aaaagtcaaa gcagtgattc agcacaattt tccgaagagg
    12241 cctataaaaa gtatcaggca gctcgtgaga tgtatgaagt tacaggctac catttgaagg
    12301 atttagaagt gattgatggg cggtacgtca cgcctgaggg acgtgactta atggatgtat
    12361 ataaggaaga gcttgaaaaa gatccagtgc agaaacaaac ggcttcttat gctatatctt
    12421 actatcgttc agagctcagt aaaatcgcgg aagccgggta taatgccatt ccggatttca
    12481 tcctatcaat tgattacagc aatggatctc tgagagatgt gggacaaagc aagagctatg
    12541 ggaccggaga taccgggtgg cttgaagcat taaagcgtca aacgggtgtg aattattagg
    12601 taagctgttc atgtaggaca gcttattttt tatgagaatc taaggggtga attaatccca
    12661 atattcaaat aattgaacaa aggtgtttac ctgaaaaaaa caattgtatt ttccagagaa
    12721 atttattatg atgaaataag taatttagga gcttatataa caattttaag tttgaatttt
    12781 ctgattgtta tcactgattc atgtgaaggc aagcaggtct gctgttttct catttatgag
    12841 tattttgtta ggaggaggaa gaggagtggc aaataaagaa ttaaagaggg gcctgggcgc
    12901 gcgccatatt cagatgatcg cctt
//
