LOCUS       gnlProkkaLBJPAOGG_81   16873 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LBJPAOGG_81.
ACCESSION   gnlProkkaLBJPAOGG_81
VERSION     gnlProkkaLBJPAOGG_81
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 12:07:49
            Original ID  :: gnl|Prokka|LBJPAOGG_81
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16873
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16873
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9871:10583]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9872..10583
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16873
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16873
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             3..875
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="MKLLYAAQMTAFDKDGNINLDGIRALVRHNIDVNKVDGLYVCGST
                     GEAFMLNTDEKKQVMETVYDEANGAIDLVAQVGSLNLKEAKELAKFATDLGYPKLSAVT
                     PFYYNFTFEQIKDYYNEILKDVDNKLLIYSIPALTGVALTTDQFAELFENPKIIGIKYT
                     NADFYLLERVRNAFPDKLILSGFDEMLLPALALNVDGCIGSTYNLNAPRVREEMDAFEA
                     GDIDKARQLQNISNDMITDLIANDIYPTLKLVMKHMGVDAGYVKKPMSHPTPEMEARAT
                     AIYEKYFKN"
     CDS             909..1595
                     /locus_tag="ctg65_2"
                     /transl_table=11
                     /translation="MKNTFLNTVKGSLIISCQALPNEPLHSSFIMSRMALAAKEAGAAG
                     IRANSVVDIQAIQDEVDLPLIGLSKVDYPASPVYITPTIKEMRAVAATGCAVVACDVTG
                     QPRPNGEKLAEIVATMRTEFPDTLLMADTDTIENVKVADKLGFDIIGTTMHGYTPATTG
                     ANIADNDFAYLKEVLQATSRPVIAEGKVDTPEKMKRCLDLGCHAVVVGGAITRPLEIAQ
                     RFISAL"
     CDS             complement(1734..2939)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 125.7; E-value: 3e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-54, bitscore:
                     175.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLDQTNNYRYVIVGGGMVAGYAIKGIRQEDPEGAILVISQEAD
                     VPYERPALSKKLWLDDEFTEENIRIGAEDYPNVTFKFKTTVTAINRQDKVITLTDSEQI
                     KYEQLLLATGGEPRQIQGPADPHVLVFRQWSDYRKLRKFSGPNKRVVIIGGGYVGTELA
                     SSLTQNGTKVTMIFPEKALGEGKFPESIRAEYEATFKRNGVTLMSGQFVQSYQRQGDHL
                     TLLTKDGTAIAADTIIVGLGVTPRISLAEDSSLDLADGGVKVDEYLNTSDPAIWSAGDI
                     ASYPDHILGRQRIEHVDHARLSGELVGRNMAGAHMSYQHTPYFYSMIFDISWQAIGNID
                     PKLQLIFDRRTHGSLVYFIDAGKLVGVLVWNVKVNLDDVRALLANAPATDDLVGSIREQ
                     EG"
     CDS             3407..3778
                     /locus_tag="ctg65_4"
                     /transl_table=11
                     /translation="MRLWHEQLIHQLPRQQLLGQHRELAALRGNGWGKNHATVNYVFKY
                     SPYKLYQFHVLVMDEMQLRGYHPNKIWYDPNYRGQFCPPYDHLTPIALTTPIYPEHNAS
                     YLAECVRNLAAKGIIMPTT"
     CDS             complement(3974..4522)
                     /locus_tag="ctg65_5"
                     /transl_table=11
                     /translation="MSKLIAKNVFQLPKMNLLVLTTSAFLLALDVILYKIAIGPAYFQL
                     SFGFLSMACIGYLYGPIWGGLLEMISDILSFTIFGSGAFQIAFLLTAFLGGFIDGLFLY
                     RKSVNWLSVVMTQILVMIFVSLMMDSWLISVLFGTNFKVLLLGRLARVIIQIPLQVIAI
                     FYFIKALEKRHVFDRMRLR"
     CDS             complement(4717..4851)
                     /locus_tag="ctg65_6"
                     /transl_table=11
                     /translation="MIKSILKFCLAAILIVSGVLIGGTVLTAKGIDNLGDKLQDKLHG"
     CDS             complement(4868..5113)
                     /locus_tag="ctg65_7"
                     /transl_table=11
                     /translation="MHWLWVLIIGAIIGAIAGAITNKGKSMGWISNIIAGLVGSAIGEA
                     LLGSWGPQLAGMAIVPSIIGGVIVVAITSFVLTRMD"
     CDS             5459..6913
                     /locus_tag="ctg65_8"
                     /transl_table=11
                     /translation="MTEKLTTETGQPWANNEHSQTAGARGPVLMQDYNLLEKLAHFDRE
                     RIPERVVHAKGAGAKGFFELENDMGEYTKADLFNGVGKKTPVILRFSQVAGEKGYPDTV
                     RDVRGFALKFYTQQGNYDLVGNNTPVFFVNDPLKFPDFIHSQKRDPKTNRRTQNMQWDF
                     WAHSPESLHQVTYLMGDRGLPASYRTMNGYGSHTFKWVNQNGEQFWVKYHFISDQGVKN
                     MTAQAAEKAMSQDLDYLQDDLYDAIQEKNYPSWTMYVQILPYEEGLNYKWDIFDVTKVI
                     SHKDYPLIKVGKLTLNENPTNNFTDIEEAAMSPANFVPGIEPSPDKLLQGRLFSYKDAQ
                     RYRLGANFEDLPVNKPVVPVHNYERDGYMKINNQGAEVNYEPNALHGPEEVPDAALSPD
                     SVRGETRAQPYRYQVDYTTQAGDLYRLMSEPEQERLINTIKDALGQVTLPGVKELEIKQ
                     FYEADKNYGTRVANALGMNIADIISD"
     CDS             complement(7071..7508)
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MIRLYTQSSCHSSRVARQWLEAHGIEFKEKNFSVDSPTVQDLKRI
                     LSLTEHGVDDIISARSKDYPEIAPKLPEMPLNEALKLLCDHPKLLRRPIIISDSKIQVG
                     FNEDDIRQFIPRPVRRLKFNALLSRLDGNTGDHIINKRMVE"
     CDS             complement(7864..8607)
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MISVYICEDDPKQLQQIRQIITKVIVDQQLDMSICLACQDPHELL
                     DKVNAQQPQKAIYVLDIALNSDINGIQLASQIRDMGRRSKIIFITTHTELSLMVFQYQV
                     EALDFILKDFPDSLYERFSKVLHVAQDRFQTDENDQDDYVQIKIGETVRSINVKSIIFF
                     ESSTSPHKIVVHLDDGELEYYGLLKDVPDLSPNFYRCHKSYVVNLKRIKSLDKHLRRLT
                     MTNGEKVLCSAQANRYLAKWLAKKS"
     CDS             complement(8600..9862)
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MLVVAIQEFFFFLLIRSLLRRLFIIKFFDLMFLLIDFIASYILFV
                     YLGIYLSLLNLIVFIFYTWWYERNLMKSVIVTLQVFIWSIVMDHVSNLVMQVVRYSIGY
                     LPVFICIQLVSLVIINIVLSRTDFTPTFEQDNLNRITAISLLIIYFYIILSEGWNNNFK
                     MIFSNLVILLVMICLLLVSYGEYLKNVKTRYEVQKQRIQIQNDTRYMNEIEAHYNELRR
                     FRHDYQNMLISIDEYLKTDDLEGLQEYYQKNLAPVSNRVLKEKYNLEDLSRVKVKSIKS
                     ILFSKLSYAQSQEIEVHFDLKEPLIDIIVNELDLDIALGIMLDNAIEASVGHADGEIMS
                     AIFIEKNSTVFLIQNNVFEQLPPLWKLKEAGYSTKGKNRGIGLNSLSKIVNRNENMILE
                     TRVLGAVFLQRLTVKRVSQND"
     CDS             complement(9872..10000)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_12"
                     /sec_met_domain="TIGR04223 (E-value: 7.9e-08, bitscore:
                     22.6, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDRMFKLLGHLFQYVGGKQLVMCCTGLLFEVKIPDELKSKD"
     CDS             complement(9981..10583)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_13"
                     /sec_met_domain="AgrB (E-value: 3.1e-36, bitscore: 114.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKPEQKLLLYKLSDRLFAAIQKNLQLERRQALLVKLGIDTVLNV
                     IPKLIITIILALLLHELVPVLVFMGSFLVLRGFAYGRHLKSDLLCTILTIFVFVGVPYI
                     VNFFDSIPGMMRGILGLILTVAIGLLAPADTLKNPITSKSLRKKLKKQAILLASMLSVL
                     QLVVNPYFGMIILISMVIAVLLLVPLKGGKTNERSNV"
     CDS             complement(10951..13065)
                     /gene_functions="other (smcogs) SMCOG1223:ATPase (Score:
                     961.7; E-value: 5.4e-291)"
                     /gene_kind="other"
                     /locus_tag="ctg65_14"
                     /transl_table=11
                     /translation="MANFYGNDPFFNNDMDDVFNQLFRRMDNQNSERARYLVNGQSLTP
                     DEFAQYRATGKLPQNNKTIEVSKDGKQAVKKGGILEKLGTNLTEQARDGLLDPVIGREN
                     EIQETAEILSRRTKNNPILVGDAGVGKTAVVEGLAQAIVAGKVPETIQDKEIYSIDLSS
                     LEAGTQYRGSFEENIKQLVKEVKAAGNIILFFDEIHQIIGTGATGGEDGGKGLADIIKP
                     ALSRGELTVIGATTQDEYRNTILKNAALARRFNDVVINEPTAADTLRILQGVKKLYEKH
                     HHVVLPDDVLKAAVDYSIQYIPQRTLPDKAIDLIDMTAAHLAAKNSQTDVETLDQRVKK
                     LEAAKEAAVKSEDFTKAADIKKSIEETKQKIKKTDQKEKITATIDDVAQSVERLTGIPV
                     ADMGANDIEHLKNLDKRLKSKVIGQDEAVEMVAKAIRRNRAGFSEGDQPIGSFLFVGPT
                     GVGKTELAKQLALDMFGNKNAIIRLDMSEYADRTAVSKLIGTSAGYVGYEDNANTLTER
                     VRRNPYSIVLLDEIEKADPQVLTLLLQVMDDGRLTDGQGNVINFKNTIIIATSNAGFGN
                     EALSGDKQRDQSLMDKLAPFFRPEFLNRFNGIVEFSHLTKQDLSQIVDLMLADVQKTLA
                     KKSIKLEVTKAAKDWLMEQGYDEAMGARPLRRVIEQQIRDKVTDFYLDHLDVKNLKADL
                     VDAEIVISAA"
     CDS             complement(13456..13689)
                     /locus_tag="ctg65_15"
                     /transl_table=11
                     /translation="MSVENNYCKLQQAHDQKCRVSLRFYKTNGQMAETVGYVTTIVPKA
                     IAFMAITGHRHLIQLNRIITVSLQSQDRRYVM"
     CDS             complement(14326..15426)
                     /locus_tag="ctg65_16"
                     /transl_table=11
                     /translation="MTVINGYEQSDREQKLTILNLPSLEAAAKKIIPSGGFGYISGGSE
                     DEWTLKQNTMAFNHVQIVPRALTDMEQPSTQTQAFGIDLKTPIMMAPAAAQGLAHARGE
                     AATAEGMAQVGALMAQSTYSSTSIADTAAAGKGAPQFFQLYMSKDWDFNQSLLDEAVKA
                     GAKAIILTVDATVDGYREADIINNFQFPIPMANLTKFSEGDGKGKGIMEIYAAAAQKIS
                     PADVRRITEYTNLPVIVKGIQSPEDALLAIGAGAQGIYVSNHGGRQLNGGPASFDVLHE
                     IAQAVNGRVPIIFDSGVRRGSHVFKALANGADLVALARPIIYGLALGGAQGVASVVSHL
                     NDELLIDMQLAGTKTIEDVKRAKLLR"
     CDS             complement(15453..16871)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 339.8;
                     E-value: 5.2e-103)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_17"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.1e-09, bitscore:
                     27.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-32, bitscore:
                     103.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFFQEMNQDPIFADVAEFHKQVTTAEQIPYVVDEAIRSAYATRS
                     VSVVIIPDDLSGQDIEFDGFKTASLSGSQQVLMPKSDDVQQTIAALKAAQHPVLWIGKG
                     AYNARQEVIAVSEKFSLPVLSTAPATGIMPTDHPNFMGSRGRLGTKPAFEVSQAADLVL
                     FVGTNFPFARYLPQGIKFIQVNNNLADLGKQHDADITVLADAKEFFQALLQSEVTIKPT
                     KFLKAAQRDKQNWNRWLKTIATDDQGGLTAEGVLEAIKDNATDDAVFGLDVGNNTEWAI
                     RQLPLNKQQTFTMSAWYGTMGFGLPAGLAAQLNYPKKQVWSISGDGGYAMVMPDLLTEV
                     KYHLPVINVVLENKVLGFIQHEKLLANQAPYGIDLIGADWAKMADNMGAIGFKVTNLKE
                     LKATFQKVTQLQQNGNQLPIVIDAKIKNVDPIDTSFVPVDPENFDADTIAKYRERYGIA
                     EADQPALSQLLNEL"
ORIGIN
        1 gtaaaaaact attatatgca gcacaaatga cagccttcga caaagacggt aatattaatt
       61 tagatggcat ccgtgctctc gttcgccaca acattgacgt caataaggtt gatggcttgt
      121 atgtttgtgg tagtactggt gaagccttca tgctgaatac tgacgaaaag aaacaagtca
      181 tggagaccgt ctatgatgaa gcaaacggtg cgattgactt agttgcccaa gttggctcac
      241 taaatctaaa agaagctaaa gaactcgcta agtttgcgac tgatcttggc tatccgaaat
      301 tatcagccgt aacgcctttc tattacaact ttacttttga acaaatcaaa gactactaca
      361 acgaaatcct taaagatgtt gacaacaaat tattaatcta ttccatccct gctttaactg
      421 gtgttgcctt aacaaccgat caatttgcgg aactctttga aaatccaaag atcatcggaa
      481 tcaagtacac caacgcagac ttttacttac ttgaacgggt acgcaatgcc tttccagaca
      541 aactcatctt atctggattt gacgagatgc ttttgcctgc ccttgcattg aatgtcgacg
      601 gttgcatcgg ctcaacgtat aacttaaatg caccacgtgt tcgtgaggaa atggacgctt
      661 ttgaagctgg cgatattgac aaagcacgtc aactgcaaaa catcagtaac gatatgatta
      721 ctgatttaat tgccaacgac atttatccaa cgcttaaatt ggtcatgaaa catatgggtg
      781 ttgatgccgg ttacgttaag aaaccaatga gccatccaac ccctgaaatg gaagcaagag
      841 ctacggcaat ttacgaaaaa tacttcaaga actaatctaa tttatactag tagaaagcgg
      901 tcttttttat gaaaaataca ttcttaaata cagttaaggg atcattaatt atctcgtgtc
      961 aggcgttacc taatgaacca ctgcatagtt catttattat gtcacgaatg gcccttgccg
     1021 ctaaggaagc tggggccgcg ggtattcgcg ctaattccgt tgttgatatt caggccattc
     1081 aagacgaagt tgatctaccg ctcattggtt taagcaaagt cgactatccc gcctcacctg
     1141 tttacatcac gccaacaatc aaagagatgc gagccgttgc tgctacgggc tgtgccgtag
     1201 ttgcctgcga tgtcacgggt cagccgcgtc ctaacggtga aaaattggca gagattgtgg
     1261 ccaccatgcg aacagaattc cctgataccc tcttgatggc tgatactgat accatcgaga
     1321 acgtcaaagt agcggataag ttaggctttg atattattgg gaccacgatg cacggctaca
     1381 caccagccac gactggtgcc aacattgctg ataatgactt cgcctactta aaggaagtcc
     1441 tccaagccac atcacgccct gttatcgctg aaggtaaggt ggatacgccc gagaagatga
     1501 aacgttgcct tgacttaggg tgccacgcgg tcgttgtcgg gggcgccatt acccggccac
     1561 tcgaaatcgc acaacgcttc attagcgcct tataatttta gacattaaaa ataaaagcca
     1621 gtcgtaagca aaataactta cggctgactt ttcatttgtt actgaaccat cgttaatgat
     1681 ggtcgatttg tcctgacgta tattcacaat agcgcaaatg tctcatccag atactatccc
     1741 tcttgctctc gaatggaacc taccaaatca tccgtggctg gagcgttcgc aagcaatgcg
     1801 cgaacatcat caaggttcac cttaacattc caaactaaaa caccaactaa cttaccggca
     1861 tctatgaaat aaacaagcga tccatgcgtt cgccgatcaa aaatcaattg caatttagga
     1921 tcaatattac cgattgcttg ccaggaaata tcaaaaatca tggaatagaa gtatggggta
     1981 tgttgatagc tcatgtgagc acctgccata ttacggccaa ctaattcacc agaaagtcgg
     2041 gcgtggtcca cgtgctcaat ccgttgccga cccaagatgt gatctggata agaggcaata
     2101 tctccagcag accagatggc tgggtcacta gtattgagat actcatcaac tttcacacca
     2161 ccatcagcta aatccaaact actatcttca gccaaactaa tccgcggcgt gacacctaac
     2221 ccaacaataa tcgtatcggc tgcgatcgcc gtaccatcct ttgtcaatag agtcaaatga
     2281 tcaccttggc gttgatatga ttggacaaac tgaccactca tcagtgtgac accattacgt
     2341 ttgaacgttg cttcatactc agcccgaatg gactcaggaa atttaccctc gcccagcgct
     2401 ttttctggaa aaatcatcgt aactttagtc ccattttgag tcagtgacga tgcgagctct
     2461 gtaccaacat atccaccacc aatgatcaca actcgcttgt tcggaccact aaatttacgt
     2521 aacttgcgat aatctgacca ctgtctaaag actagcacat gtggatcagc aggtccctgg
     2581 atttgtcgag gttctccgcc agttgccagc aatagctgtt catacttgat ttgctcacta
     2641 tcagtcaatg taatgacctt atcttgccga ttaatagccg taaccgttgt cttgaactta
     2701 aaagtcacat taggataatc ttcagcacca atccgaatgt tctcttcagt aaactcatca
     2761 tctagccata gctttttact cagtgccggc cgttcatacg gaacatccgc ctcttgcgaa
     2821 ataactaaga ttgcgccctc tggatcttcc tgtcgaattc ccttgatggc atagccagca
     2881 accattccgc caccaacaat gacgtatcga tagttgtttg tctgatccaa atcactcatt
     2941 taatcgcctc cataacttta ctttttctag gaccattgta atataaaaac gccatgattc
     3001 gaaaaatgac gctcaagatt attaatcatt gattcctttt atcagaacaa taattttatt
     3061 tgcataccgt caaacatcta tcaaacaccg ctgtgatcaa aattaagaac tgctgctaac
     3121 acaacataaa ataatgttat ttttaattac tcaacccaac tttcaaggta agcattctaa
     3181 ggaatgtttg atcatatcag ttgttgctat ggccgttttt tttgatcttg tactaaacta
     3241 ttgatcaatt cgctatgcta taataattgc gaatattcac tttaactatc cgtcgtttac
     3301 aatcatcacc cgttcaaaag tatcagtata ttcggcatca taatgatgag ttggtccttt
     3361 taatattcac ctgttaattt taaaattcga taagggagtg tggcctatgc gtctatggca
     3421 tgaacaatta atccatcaat taccacgaca acaattacta ggtcaacacc gtgagcttgc
     3481 cgcattgaga ggcaatggtt ggggtaaaaa tcatgcaacc gttaattatg ttttcaaata
     3541 ttccccttac aagttgtatc aatttcatgt attagtgatg gatgaaatgc aacttcgcgg
     3601 ctatcatcct aataaaatat ggtatgatcc aaattatcgt gggcagtttt gcccgcctta
     3661 tgatcacctc actcctattg cattaacaac accaatctat ccagaacaca acgccagcta
     3721 cttagcagaa tgtgtccgca atttagctgc taagggaatt atcatgccca ccacatagcc
     3781 gctcttttat tttgctgggt accaactcaa ccatcgatac ccaaattgtt tttccgcagt
     3841 cataataagg ccagttaata ttaaaaaagg ttgaactaga cttgaagtgc aatagaaaag
     3901 ttagacttat ttgtttaacg attgtagcgc atttcatacc atgttcaacc tctttttgta
     3961 gcatccatcg atgttatcta agcctcattc tatcaaaaac gtgtcgtttt tctaacgcct
     4021 taatgaagta aaaaatagca atcacctgta atggtatctg aatgatgacg cgtgccaatc
     4081 ttcccaacaa taacacttta aaattagtgc caaatagtac tgaaattagc catgagtcca
     4141 tcatcagact aacaaaaatc attacaagta tttgcgtcat cacaacggat aaccaattga
     4201 ctgatttacg atataaaaac aaaccgtcaa taaatccccc taaaaatgca gttaacaaaa
     4261 aggcaatctg aaacgcgccg gaaccaaaaa tagtaaagct taatatatcg gagatcatct
     4321 ccaagagacc accccaaatg ggaccatata gataaccaat acaagccata gacaaaaagc
     4381 caaaagataa ttgaaaatac gctggtccga tagcaatttt gtataaaata acgtctaagg
     4441 ccaataagaa agccgatgta gtcagcacta ataaattcat ttttggcaac tgaaaaacat
     4501 ttttcgcaat aagtttagac ataggccaat cctctttttt tgattttaat cataccctca
     4561 ttcttaataa aagtaaatat tacttttatt cgattgaagg tagtttaaaa ttgtcgctct
     4621 tgatttagtt ccttgaactc aatgatatta ctcatactaa aagccactaa caggtcaact
     4681 agtacaccca tcagtggctc attgtaaaat taatttttat ccatgtaact tatcttgtaa
     4741 tttatcaccc aagttatcaa ttcccttagc agtaagtacg gtcccaccaa taagaacacc
     4801 acttacgatt aagattgcag ctaaacaaaa ctttaaaatg cttttaatca tcgcaatcat
     4861 ctccttacta atccatccgt gtcagaacaa atgaggttat cgcaacaaca atcacaccac
     4921 caataattga aggaacaatt gccattccgg ctaattgtgg tccccatgat cccaaaagag
     4981 cttccccaat tgcagatcca accaatccgg caataatatt actaatccac cccatcgatt
     5041 tacctttatt agtaatagca cctgcaattg caccaataat agcaccaatg atcaaaaccc
     5101 ataaccaatg cataaaatcc ctcctagact tattaaaccg cttaaataca ataatagaat
     5161 tacacgaata tttaagacga ttcataaatg attacttctt ataattatca ttttacaatt
     5221 atcgataatg atagacaaat ataacacatt atttaataaa tgggtcgcta ctatttctca
     5281 tgtgacaatt ccgggtggcc tagaaaatat caaacagctt gatagctgat taaaattaaa
     5341 ctacgccaca tgaacgatta acttaactgt gcataatgat tgaagtcact ctgttaaggt
     5401 gttagcgttt aaattgtgca agagctttct tgtaatttac gtgaaaaggg cgattaaaat
     5461 gacggaaaaa ttaacgacgg aaaccggcca accatgggct aacaatgaac attcccaaac
     5521 ggcaggagct cgtggtcccg tattaatgca agactataat cttttggaaa aactagccca
     5581 ttttgatcgt gaacgaattc cagaacgggt cgttcatgct aagggggccg gagcaaaagg
     5641 tttttttgaa cttgaaaacg acatggggga atatactaag gcagacttat ttaatggtgt
     5701 cggtaagaaa actcccgtaa tcttaaggtt ctcacaagtt gccggtgaaa aaggttatcc
     5761 tgacaccgtt cgagacgtgc gcggttttgc cttaaaattt tatactcagc aaggcaatta
     5821 tgatctcgtt ggaaacaaca caccggtctt ttttgtaaac gaccctttaa aatttcctga
     5881 cttcatccat tcacaaaaac gggatcctaa aacgaaccgt cgtacgcaaa atatgcaatg
     5941 ggatttttgg gctcattctc cagaatcatt gcaccaggtc acttatttaa tgggcgaccg
     6001 aggacttcct gcgtcctata gaaccatgaa tggttacggt tcccatactt ttaaatgggt
     6061 taatcagaat ggcgaacagt tttgggttaa gtatcacttc atctcagacc aaggcgttaa
     6121 aaatatgact gctcaagcag ctgaaaaagc aatgagccaa gatttagatt atttacaaga
     6181 tgacctatat gatgcaattc aagaaaaaaa ttacccatca tggacgatgt atgtccaaat
     6241 cttgccatat gaggaaggtc taaactataa atgggacatt tttgatgtca ctaaagtcat
     6301 ctcccacaaa gactatccac taattaaagt cggcaaacta actttaaatg agaatcccac
     6361 taataacttt accgatattg aagaggcggc catgtcgcca gcaaattttg ttcctggtat
     6421 cgaaccatct cccgacaaat tactacaagg tcgcctattc tcctataaag atgcacagcg
     6481 atatcggtta ggtgccaact ttgaagattt acccgtgaac aagccggttg ttccagttca
     6541 taattatgaa cgtgatggtt acatgaaaat taataatcaa ggtgctgagg tcaactacga
     6601 gcctaatgca ctgcatgggc cagaagaggt accggatgcc gcactttcac ctgattctgt
     6661 tcgtggtgaa acacgcgcac agccttatcg ctatcaagtt gattacacaa ctcaagcagg
     6721 cgacctatat cgcttaatgt cagaacccga gcaagaacgc ttaattaata ctatcaaaga
     6781 tgcgttaggc caagttactt tgcctggtgt caaagaactc gaaatcaagc aattttatga
     6841 ggccgacaaa aactacggta cacgcgtggc taatgctctg ggaatgaata ttgctgatat
     6901 tatcagtgat taatattttg accggatgtt atccagcgcg atattatttt tgttataaag
     6961 aatgatgatg ccgtctcatg gttattaact aaagagcgac aggttagact catatcgtgt
     7021 aagtctagcc tgtcgctctt taattaacaa aaaatcttag atatagctta ctactcgacc
     7081 atccttttat taataatgtg atcccctgta ttaccatcta gacgactcaa caatgcattg
     7141 aactttagtc gccgaactgg tcgtggaata aattggcgaa tatcatcttc attaaagcca
     7201 acttgaattt tactatcact aatgatgata ggccgacgta acaacttcgg atgatcacac
     7261 aacaatttaa gtgcctcatt caatggcatt tcgggtaact taggcgcaat ttcaggatag
     7321 tctttagatc gagctgagat aatatcgtct acaccatgtt cggttaaact caaaatacgt
     7381 tttagatctt gcaccgtggg cgaatcaaca ctaaaatttt tctccttgaa ctcaatccca
     7441 tgtgcttcca accattgccg tgcaactcta gaagaatgac agcttgattg tgtatataac
     7501 ctaatcattc ctaatctgcc cctctctcgt taaaattcat cacagcgtat tgatcgacat
     7561 taacttctgc ctgtcacaac atcctttaaa ctaaacgcat tcgttactgt catgaccaat
     7621 ccaatacccc gtgaacacat ctttattata ggctctgaac aagggacata ccgaccgttt
     7681 taagacgaat aatctgagga taatcgtttt aagtacactt ttaaacggtt taggaaagaa
     7741 cgaacccagt acacgtaatg ctgacaaata ccactgcaat ttctaatcga ataacgctga
     7801 attttcatca cgtagcacat aaaaagtcgc ctactaattt ggcaggcgac ttccttggaa
     7861 ctattatgac tttttagcaa gccatttagc tagataacga ttagcttgtg cagaacaaag
     7921 cactttttca ccatttgtca tggttaatcg tcgcaagtgc ttgtccaatg acttaatgcg
     7981 tttcaagtta acaacatatg acttatgaca tctatagaaa ttaggactca aatcaggaac
     8041 gtcctttaac agtccatagt attctaattc accatcatcc aaatggacta cgattttatg
     8101 gggactggtt gaactttcaa aaaatataat acttttaaca ttaattgatc tgaccgtctc
     8161 accaattttt atttgaacat agtcgtcttg gtcattttca tcggtttgaa aacgatcttg
     8221 cgccacgtgt aaaaccttgc taaatcgctc atacaaggaa tctggaaaat ccttaagaat
     8281 aaaatctaat gcctcaactt gatattgaaa caccatcaaa gataactccg tgtgtgtcgt
     8341 gataaaaata atcttgctgc gacggcccat gtcacgaatc tggctagcta gttgaatacc
     8401 attaatatct gaattaaggg caatatctaa cacatagatt gccttttgag gctgctgtgc
     8461 attaaccttg tctaacaatt cgtggggatc ttggcatgct aaacagatac tcatgtctag
     8521 ctgttgatcg acgattacct tagtaatgat ttgccgtatt tgttgtaatt gtttcggatc
     8581 atcttcgcaa atgtagacac taatcattct gagatactcg cttcaccgtc aagcgttgta
     8641 agaataccgc tcctaagact ctggtttcga gtatcatgtt ctcattgcga ttaacaatct
     8701 tacttaaact attcaatcca atcccccgat tcttgccctt agtggaataa cctgcctctt
     8761 tcagcttcca taagggtggt aactgttcaa aaacattgtt ttgaatcaag aacaccgtac
     8821 tatttttttc gataaaaatg gcactcataa tctctccatc agcatgtcct accgatgctt
     8881 cgattgcatt atccaacata atccctaatg caatgtctaa atccaattca ttaacaataa
     8941 tgtcaattaa tggttccttt aaatcaaaat gaacttcaat ctcttgcgat tgtgcatagc
     9001 tcaacttact aaataggata ctcttaatcg acttcacttt gactcgactc aaatcttcaa
     9061 gattatattt ttcttttaac acccgatttg aaaccggtgc aagattcttt tgataatatt
     9121 cttgtaaacc ttctaaatca tcagttttca aatattcatc tatcgaaatc aacatattct
     9181 gatagtcatg tctgaaacgt cgcaactcat tatagtgagc ttcgatttca ttcatatagc
     9241 gagtatcatt ttgtatttgt attctttgct tttggacttc atatctagtt ttcacgtttt
     9301 ttaaatattc accatacgaa accaataata gacatatcat aactaataaa atgaccaaat
     9361 tactaaatat catcttaaag ttattattcc atccctcact gagaatgata taaaagtata
     9421 tgattaacaa cgatatcgcc gtaattcgat tcagattatc ttgttcaaag gttggtgtaa
     9481 aatctgttcg agatagaaca atatttatta taaccaagct aactagttga atacatataa
     9541 aaacaggcag atatcctatt gagtatctca ctacttgcat aaccaaattg cttacatgat
     9601 ccatcactat agaccaaata aacacctgaa gcgtaacaat caccgacttc atcaaattac
     9661 gttcatacca ccatgtatag aaaataaaaa caatcaagtt taacaaagat aagtagatgc
     9721 ctaaatatac aaacaaaata tagcttgcta taaaatcaat taacagaaac ataaggtcaa
     9781 aaaattttat gataaacaat cgtcgcaata aggatcttat taaaagaaaa aagaaaaatt
     9841 cttgaatggc aactacgagc ataacatttc actaatcctt actctttagt tcatccggaa
     9901 ttttaacttc aaaaagtaat cctgtacaac acattactaa ttgcttacca cctacatatt
     9961 gaaaaagatg accaagtagc ttaaacattc gatctttcat tagtcttccc tcctttcaat
    10021 ggtacgagta acagaactgc tattaccatt gaaattaaaa taatcattcc aaaataagga
    10081 ttaacaacta actgtaaaac acttaacatg gatgctaata aaatagcctg cttctttaac
    10141 tttttacgta gtgactttga tgtgattgga ttttttagcg tatccgctgg cgcgagtagc
    10201 ccgattgcca cagtgagtat taagcctaat atacctctca tcatcccggg aatactatcg
    10261 aaaaaattaa caatatacgg cacacccaca aacacaaaga tagttaatat cgtacataac
    10321 aaatccgatt tcaagtgacg tccataggca aagccacgca aaactaaaaa actacccata
    10381 aaaactaaca ctggaaccaa ctcgtgtagc agcaacgcta agataatagt aattatcagc
    10441 ttaggaataa catttaatac agtatcaatg cctagtttaa ctagtaatgc ctgccgtctt
    10501 tctagttgaa gattcttttg aatcgcagcg aataaccggt cgcttaattt ataaagcaat
    10561 agtttttgtt ctggcttttc catatcccac tcctataatg ctcaaataca tacctgtatc
    10621 aacagtttaa aacagtatta attaattgaa aagaatacat aaatagatta attattcaat
    10681 attgttttaa gactagaaat aaacatttaa agatacatca gtttaattat tcatacgaaa
    10741 ctaaagtttc atataaaaag atcgttaata taaatcagtt tcatcgatac tcccccttaa
    10801 tttttcctta gattacaagt caaactagac ttaatttcac taattcacat tactcaatag
    10861 attaatatca aatggtgaaa atcaacgaaa aaaggagatc tatcaagcaa tctcctctta
    10921 cataaagtta tttatgaaca ctgatttaag ctaagctgcc gatatcacaa tctcagcatc
    10981 cactaaatca gccttcaagt ttttgacatc taagtggtca aggtagaaat ccgttacctt
    11041 gtcacgaatt tgttgttcaa ttactcgccg taatggccgc gcacccatcg cttcatcata
    11101 gccttgttcc atcagccaat ctttggccgc tttagttacc tcaagtttga tggatttttt
    11161 ggctaacgtt ttttgtacat ccgccaacat caaatcgaca atttgactta agtcttgctt
    11221 agtcagatgt gaaaattcca cgattccatt aaaacggttc agaaattctg ggcggaaaaa
    11281 tggtgctaac ttatccatta atgactgatc tcgttgcttg tcaccactta atgcttcatt
    11341 accaaagcca gcattagaag tagcgataat aatcgtattt ttgaaattaa tgacattgcc
    11401 ttgtccatcc gttaagcgcc catcatccat cacttgtaac agtaacgtta atacttgtgg
    11461 atcagccttt tcaatttcat ctaataatac aatggaatat ggattacgcc gaacccgttc
    11521 agttagagta ttagcattat cttcatagcc tacgtatcca gccgaggtac caattaattt
    11581 cgacacagct gtacgatcag catattcact catatctagc cgaataatcg catttttatt
    11641 tccaaacata tctaaggcta attgcttagc taattcagtc tttcctacgc cagttgggcc
    11701 cacaaacaga aaacttccaa ttggctgatc accctctgaa aagcccgcac ggttacgccg
    11761 aattgccttc gctaccattt caaccgcttc atcttgaccg attaccttac ttttcagacg
    11821 cttatcaaga tttttcaagt gctcaatatc attagcgccc atatcagcaa ctggtatacc
    11881 agttaaacgt tcaaccgatt gtgccacatc atcaatcgtg gcagtgattt tttctttttg
    11941 atccgttttt ttaatttttt gcttggtttc ctcgatcgac ttcttgatat cagcggcttt
    12001 tgtaaagtcc tccgatttaa cggcggcctc cttagctgcc tctaattttt taacgcgttg
    12061 atccaatgtc tcaacatcag tttgcgaatt tttagccgct aaatgagccg cagtcatgtc
    12121 gatcaaatcg atagctttat ctggcaaagt gcgttgtggt atatattgga ttgaataatc
    12181 cacagccgcc ttcaaaacat catctggtaa tacaacatga tgatgctttt cgtacagctt
    12241 tttaacacct tgtaatatac gtaaagtgtc agcggccgtc ggttcattaa tcacaacatc
    12301 attgaatcgc cgtgccaaag ccgcattttt caaaatagta ttgcgatatt catcttgagt
    12361 cgtagccccg attacagtca gctcgccacg tgacaaagca ggtttaatga tatcagccaa
    12421 tcctttgcca ccatcttcac caccagtggc gcccgtgccg ataatctgat gaatttcatc
    12481 gaagaataga ataatattac cagctgcttt aacttccttt actagctgtt taatattttc
    12541 ttcaaaagaa ccgcgatatt gagttcctgc ttccaaagac gataaatcaa tcgaatagat
    12601 ttctttatct tgaatcgttt ctggaacttt accagccaca attgcttgtg ccagaccttc
    12661 gacgactgca gttttaccta caccagcatc accaactaag attggattat ttttcgtcct
    12721 acgactcaaa atttctgcag tttcttgaat ctcattctca cgtccaatca ctggatctag
    12781 taatccatca cgagcctgtt ccgtcaaatt agtccctaac ttttctaaaa tccccccttt
    12841 tttaacagcc tgtttaccat ctttagatac ttctattgtt ttattatttt ggggtagctt
    12901 accagttgct cggtattgag caaactcatc cggtgtcagc gattgtccat taactaaata
    12961 ccgtgcacgc tccgaatttt gattatccat gcgccgaaat aattgattga aaacatcatc
    13021 catatcattg ttgaaaaaag gatcatttcc gtagaaattg gccatattac aacacctcca
    13081 taaaaattta tatgtggaac ttagtgacca taatatcctt taaaactaca actgaatcgt
    13141 atcacgattt ttatgtatcg ttaagcaaag tgcttataga atcaattaga aataattaga
    13201 ataattttgt ttaaacaaaa gagaaatcaa tttcataaaa tgaattgatt tccctacaag
    13261 gttccctatt taatagccct tgataaagaa cttgaattaa caagttactt tccagaccaa
    13321 ttttaattta agagactgcg actcaaaaag cacacccagt atcaagttaa ggccaactag
    13381 ttatcgttaa tattgccact taaatatcaa tactagcaat catgatacac gcgtaaaatc
    13441 ataaaccaaa acatattaca tgacgtaacg gcggtcttgg gactgtaaac tcacagtaat
    13501 gattctattg agttggataa ggtgccgatg accagtaatt gccataaatg caattgcttt
    13561 cggtacaatc gtagtgacat agccaactgt ctcggccatc tgcccatttg ttttataaaa
    13621 ccgtaatgag actcgacatt tttgatcatg cgcttgttgt aatttacaat aattattttc
    13681 aacactcaaa ttaaagtctc ccgttcaaag aattcaggtt tatttattcg tcagtgaatc
    13741 tatgtgtttg tttttctcat tgttgacggc gtaagtccac attaaggagt cagctattca
    13801 gtaaaaacta aataactagt attcatgttc agctcagtat aatatgcatt gatggttact
    13861 aatcaaaaat cgatctctaa atatcctaat tactatgaaa ctttgaagtt aatttatgag
    13921 aaaaataact cacaacaaaa ctcatgatta caaccttgtc atcataacta gattatgaaa
    13981 cattcagcct cctaaataaa actggtatgc gcgcatgtgc gcatgtgtac agtatactat
    14041 tgccaagtat gtctgaataa ccgttttaag acttgaaaaa ctcagctggg tgctttagga
    14101 cgctttttgt gcattttaag acaatatcct aacttcaacg ccggcatagc ttcaattcgt
    14161 caatcagtgt cttagttcct cagctatttc tgttcagaac atcttcctat tacaataaaa
    14221 agcgttgatc tcagcagaat ttacttccac caaaaccaac gctaaagtgt tattatatca
    14281 ggtattttaa attcatttca gacattatat tcagcattac ttctactacc taagtaattt
    14341 agcacgttta acatcttcaa tcgtcttagt tcccgctagt tgcatatcga tcaacagctc
    14401 atcattaagg tgactcacta cggaagcgac accctgcgca ccacccaatg ctaatccata
    14461 gataatcggc cgagcaagtg ccaccagatc tgcaccattg gctaacgcct taaagacatg
    14521 ggagccacgc cgaacaccgc tatcaaaaat tattgggacg cgcccattaa cggcttgcgc
    14581 aatctcgtgt aaaacatcaa aggaagctgg accaccattt agttgccgac cgccatggtt
    14641 tgaaacatag ataccctgag caccagcccc gattgctaac aaggcatctt ctggtgactg
    14701 aatccccttc acaataactg gtaaattcgt atattccgta atacgccgaa catcagccgg
    14761 gctaatcttt tgcgccgcag cagcatagat ttccatgata cctttccctt taccatcccc
    14821 ttcgctgaac ttagtcaagt tagccattgg gattggaaac tggaaattgt tgataatatc
    14881 agcttcacga taaccgtcaa ctgttgcatc aactgtcaaa atgattgcct tagcaccagc
    14941 cttcactgct tcatccagta aactctgatt aaaatcccaa tctttgctca tatataattg
    15001 gaaaaattgg ggcgcacctt taccagctgc ggcagtatct gcaattgacg ttgaagagta
    15061 agtactctga gccataagtg ccccaacttg agccatccct tcagcagtcg cagcttcacc
    15121 ccgtgcatgt gccaatcctt gagcggccgc tggagccatc ataataggcg ttttgagatc
    15181 tatgccaaaa gcttgagtct gtgtgcttgg ctgttccata tccgtcaatg ctcgtggcac
    15241 aatttgaaca tggttaaagg ccattgtatt ctgctttaaa gtccattcgt cttctgaccc
    15301 accactaata tagccaaagc ctccgctcgg gatgatcttt ttagcagctg cttccaatga
    15361 tggtaaattt aaaatcgtta acttttgctc acgatcactc tgttcatatc cattaataac
    15421 tgtcattata ctaatctcct ttacataacc ctttataatt catttaataa ttggctaagt
    15481 gccggttgat ccgcttcagc gataccatat cgttcacgat acttagcaat cgtatctgca
    15541 tcaaagtttt ctggatctac tggaacaaaa ctagtatcaa ttggatcaac atttttaatt
    15601 tttgcatcaa tcacaattgg tagttgatta ccattctgct gtagttgagt aactttctga
    15661 aacgttgctt tcaactcttt aaggttagtc actttaaaac caatcgcacc catgttgtct
    15721 gccatcttgg cccaatcagc accaatcaag tcaatcccat acggcgcctg attagcgagt
    15781 aacttttcat gttgaataaa gcctaatact ttgttttcta aaaccacgtt aatgactggc
    15841 aaatgatatt taacttccgt tagtaagtct ggcatcacca tggcataacc accatcacca
    15901 gaaatactcc aaacctgctt cttaggataa ttcaattggg cggccaaacc tgctggcaaa
    15961 ccaaaaccca tcgtgccata ccaagccgac atcgtaaaag tctgttgctt attcaatggt
    16021 aactgtcgga ttgcccattc cgtattattc ccaacatcca gaccaaagac ggcatcatca
    16081 gtagcattgt ctttaatagc ttctagcacc ccttcagccg tcaaccctcc ttgatcatca
    16141 gtagcaattg tcttgagcca ccggttccag ttttgcttat cacgttgagc agctttcaag
    16201 aacttagttg gcttaattgt cacttcggat tgaagtaatg cttggaaaaa ttcttttgca
    16261 tctgcaagaa cagtaatatc agcatcatgt tgtttgccta aatctgctaa attgttattg
    16321 acttgaataa acttaattcc ttgtggcaag taacgtgcaa acggaaagtt agtaccaaca
    16381 aacaaaacta gatctgccgc ttgcgagact tcaaaggcgg gtttagttcc tagtcgaccg
    16441 cgagagccca tgaaattagg atggtcagtt ggcataatac cagttgctgg agccgtcgac
    16501 aaaaccggca aactaaattt ttcagaaact gcgataactt cttgacgcgc attataggca
    16561 cccttaccaa tccataaaac agggtgttga gcagctttca aagccgctat cgtctgctga
    16621 acatcatctg atttcggcat taaaacctgt tgactgccgc taagtgaagc cgttttaaaa
    16681 ccatcaaact caatatcttg accagacaaa tcatctggaa tgataacaac agaaaccgaa
    16741 cgggtcgcgt atgctgatct aattgcttca tcaaccacgt atggaatctg ttcagccgtt
    16801 gtcacttgtt tatgaaattc ggctacatct gcaaaaattg gatcttggtt catttcttga
    16861 aagaagttcg tat
//
