LOCUS       gnlProkkaCCADKMLJ_69   10499 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CCADKMLJ_69.
ACCESSION   gnlProkkaCCADKMLJ_69
VERSION     gnlProkkaCCADKMLJ_69
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 07:01:31
            Original ID  :: gnl|Prokka|CCADKMLJ_69
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10499
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..186)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 2e-17,
                     bitscore: 54.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.1e-09, bitscore: 27.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVAAMLAKY
                     GSRPDVTEEDLRQCIDD"
     protocluster    1..10499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[0:499]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..10499
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10499
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(272..499)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg66_2"
                     /sec_met_domain="TIGR03973 (E-value: 1.2e-25, bitscore:
                     80.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 7.2e-25, bitscore: 77.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISYYKIKAYRNYVRRDKFLRVREVSIMERIKTIATRDLTKSVKT
                     GGCGECQTSCQSACKTSCGVANQQCENSNK"
     CDS             complement(447..542)
                     /locus_tag="ctg66_3"
                     /transl_table=11
                     /translation="MKRLSEKILTKGALRDILLQDKSVPELCPAR"
     CDS             complement(539..826)
                     /locus_tag="ctg66_4"
                     /transl_table=11
                     /translation="MPERTTQNAQTLLSPRVPRDTEHERYHPELEEELKECLFCLKRNE
                     MMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHTVLTRYQPMGG"
     CDS             complement(1263..2957)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 251.1; E-value: 4e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg66_5"
                     /transl_table=11
                     /translation="MAIGAPAASACWFGDKSDVTILYTNDVHTYIDKQSPKLTYAAIAD
                     LKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIKLMNAAGYDVATPGNHEFDYGMD
                     RAKAIMKEADFPYLSCNWVDLRTTLRVLPSVKVFVRGGRRIAFVGVTTPETFTKSTPAY
                     FMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLADVVIGLGHLGVDPSSSPWTSEE
                     VIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQTGSYFANVGEMTIAADGTITTK
                     LIPTHEGMDAGIAAMQTGWVNTVDDMLGEKIAVGDSDFYVSDPATGKRRIRSAETNLGD
                     FVADGIYTYFNEVEKLHCDVAIMNGGGIRADVPAGDWTFKTCKQVSPFGNVACLMSVTG
                     KQIQDALEFAARFAGEDGKENGGFLQVAGATYEIHTDIPNTVQTDEKNVWIGSATGTPR
                     VQNVKIYDKASGSYLPLDLGATYALAGMNYTLRNLGDGFAMFDGAELIKDYVSEDYLVM
                     STYAMIFDGADAAGLPHLSSANSPLAAYPGYLLNYEQPYGAGRITIL"
     CDS             complement(2914..3060)
                     /locus_tag="ctg66_6"
                     /transl_table=11
                     /translation="MRYAKNKRRSFSCETTYFPSQLFKGCWCDRCRCIHGHRCACRIGL
                     LVW"
     CDS             3061..3255
                     /locus_tag="ctg66_7"
                     /transl_table=11
                     /translation="MRQALPSCPFNSSSIAQNTAANKPKSFFWNKLFSRFALFWHTLYH
                     FYTKKASPCPVAEQRRGLF"
     CDS             complement(3300..5015)
                     /locus_tag="ctg66_8"
                     /transl_table=11
                     /translation="MDHKSAYIIGSGLAALTAACYLVRDGQMKGEHVHVFEKNALAGGA
                     CDGYKYDIGYVMRGGREMDNHFEVMWDMLHSIPSLETEGASVLDEYYWLNKEDPNFSLC
                     RATVNRGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDKKITDFFDDEVLNSNFWMYW
                     RTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRYNQYESIILPMVRYLESFGV
                     QFHYNTKVTDVKFDIQKGRKLASSVTVEHEGETTNIDLTENDLLFITNGGCVESCTVGA
                     QDKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEPELSNWESATITTLDDKIPQ
                     YIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQFKDQPKNQLCVWVYGLFSDK
                     PGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSANTVPVMMPYIDAFFMPRAM
                     GDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGMEAVYTLLNIDRGVPEVWGST
                     YDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIEGTDLEKFLKEYNAI"
     CDS             complement(5440..5703)
                     /locus_tag="ctg66_9"
                     /transl_table=11
                     /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTIASIEVVGGCNGNLKGICQ
                     LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEQMN"
     CDS             complement(5709..6524)
                     /locus_tag="ctg66_10"
                     /transl_table=11
                     /translation="MPIERLASIAARTGLHAIALSDHDTLLSAQYAYAHTGQDGVELIP
                     AVELTGYDFDRQHRVHLLCYYPDVDCPALREHCAIMKERRNACALQSAKELEQLYPQFT
                     TDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGWNPRGIVLHSPEYLPV
                     RQVLATAKASGGAVVFAHPTVYKSMPLLRELAAEGAVDGIEVYHPSNSPEDSAECLALC
                     KQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAVAQLRAIAEKRKRERT"
     CDS             complement(6584..8803)
                     /locus_tag="ctg66_11"
                     /transl_table=11
                     /translation="MPADGNAPAALAAKGFDAAAVAAAKTGTMAYNIMQAHNTSGDVEN
                     LKIKFDAMASHDITFVGIIQTARASGLEKFPIPYVLTNCHNSLCAVGGTINEDDHRFGL
                     SAAKKYGGIFVPPHMAVIHQYMRERFAGCGKMILGSDSHTRYGALGTMAIGEGGGELAK
                     QLLGRTYDVARPGVVAIYLTGSLPAGCGPHDVAIALVGKLFKSGYVKNKVMEFVGPGIA
                     SLRQDTRNAIDAMTTETTCLSSIWETDEVTQRFLAVHGRAADYKKLAPADLAYYDGVVE
                     VDLSAIRPMIALPMHPSNAFTIEELNANLEDILHACEQDVQKLIGRKDVQLDLCSKIEN
                     GKLRVDQGVIAGCAGGLYDSIYEAASILKGHTGGCGDYALSVYPGSQPIMMELVRTGVI
                     SELMASGATIRTAFCGPCFGAGDVPANGALSIRHTTRNFPSREGSKPGSGQLSGVALMD
                     ARSIAATTANGGILTPATDVDYDPTVPEYQYDASSYDTRVYQGFGKGDYDALLKFGPNI
                     KDWPEIAPLGDNLLLKVASYITDPVTTTDELIPSGETSSYRSNPLGLAEFTLSRKDPEY
                     VGRAKAVQAEENARRAGAGDAALLAKVNAVPGCEQLNWNDIQIASTIFAVKPGDGSARE
                     QAASCQRVLGAGANIVTEYATKRYRSNLINWGMLPLQLAGATPFGLGDYVLIPNVREVL
                     KGDLQNIKAYVLGDTVKEFELYMAPLTTDERQILADGCLINFYKH"
     CDS             complement(9021..10382)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 290.8; E-value: 2.7e-88)"
                     /gene_kind="transport"
                     /locus_tag="ctg66_12"
                     /transl_table=11
                     /translation="MTKDMTQGSPLKLLLAFAVPLMLGSLFQQFYNLADTIIVGRFVGV
                     EALAAVGSVGGLNYLVLGFVNGIACGFSIPISWTFGAHDHHEMRRYTANTVWLSIAFAT
                     VLTIVTVAMTHLVLVWTNTPADIIDLADIYIRTIFAGIPFTLLYNVTSALMRALGDSKR
                     PLYFLLVASVLNIGLDLACIILFNMGVFGAAFATVFSQAVAGIGSLIYIMRHYPELRWN
                     KEEGRISAPHCAKLCAMGLPMGLQCSITAIGSVVLQGAVNGLGSDIVAAQTAGGKAAQF
                     LSVPLESIGTAMTTYTSQNMGAKDLGRVNRGVNTALGIGCVYSVASFLILRVLDKPLIG
                     LFLDAGETAIMANAQDFIFWNSVFYIPLAVLIIYRYTIQGLGHSGLAMFAGVAEMIARA
                     MVGFWFVPLWGYFAACIASPVAWLFACFFLIPAYFVVFRRLQKEKQQEAAAKVQ"
ORIGIN
        1 gtcgtcgatg cactggcgca gatcctcctc ggtcacgtcc gggcggctgc cgtactttgc
       61 cagcatggcg gcaacgatct cgtctgcggt atgctccggg tacatggcga tgacatcgta
      121 ggccacctcg tccacaacgt gcaccgagcc gctgcaggtg tccagcacga tgttataacc
      181 gttcaattga tactgatgta ccattttaca ctccattcca gattacacaa aaaaatgccg
      241 cccggcaaag gcggcataag gtttgcaaaa attacttgtt gctgttctcg cactgctggt
      301 tagccacgcc gcaggaggtc ttgcaggcgg actggcagga agtctggcac tcgccgcagc
      361 caccggtctt aacgctcttg gtcaggtcac gagtagcaat agtcttaata cgctccatga
      421 tagaaacctc tctaactctc aaaaatttat cgcgccggac atagttccgg tacgctttta
      481 tcttgtaata ggatatcacg cagcgcgcct tttgtcaaga ttttttcgct aagccttttc
      541 acccgcccat gggctggtag cgggtaagca ccgtgtgcag ccccagttcc cgggcgcgcg
      601 ccagtaagta ccggtagcgg cacagcagcg cctgccgctc gtagatgcgc tgctcgatca
      661 ggtccgtatc cacctccata tcaaacatca tctcgttgcg cttcaaacag aacaggcatt
      721 ccttcagctc ctcctccagt tccggatggt agcgctcgtg ctcggtatcc cgcgggacgc
      781 ggggcgaaag cagggtctgg gcattctgtg tggttcgttc cggcataggc atcctccttc
      841 tggtgctttg taaggttttg taccttccag tataggcggt gcggtgcgca gaacctgccg
      901 aagcgtggca gcgctccggc atagattatc cggcgctgct gcggcatttt ccaaaaaagt
      961 acaacttttt tcaaaaatat gcttgacaac tccgggcttt tcccgtataa tagcacacgt
     1021 tgagcggctc accccgcaaa acacaacaga atattgggga tttgcatagt ggtagtgcgg
     1081 tagactctga ctctacttgt gggagttcga ttctctcatc cccaaccaga ctaaagccat
     1141 ctgaggaagc tcaggtggct tttctgtttg tatgattccg cgcggaaaaa ctattataga
     1201 tagagcgaac ccggaaagtc cgcaggactt tccgggttcg ccttttcacg ggaaatataa
     1261 atttacagaa tggtgatgcg gcctgcgccg tagggctgct cgtagttgag caggtagccg
     1321 gggtatgcgg ccagcgggct gttggcgctg gacaggtgtg gcagacccgc agcatctgcg
     1381 ccgtcaaaaa tcatagcgta ggtagacatc accagataat cctcggacac atagtccttg
     1441 atcagctctg cgccgtcaaa catggcaaag ccatcgccca gattacgcag ggtgtagttc
     1501 atgccggcca gtgcgtaagt agcgcctaga tccagcggca gatagctgcc ggaggcctta
     1561 tcgtagatct tcacgttctg cacgcgcggg gtgccggtgg cgctgccgat ccagacgttc
     1621 ttctcgtcgg tctgcacagt gttggggata tcggtgtgga tctcgtaggt agcaccggcc
     1681 acctgcagga agccgccgtt ctccttgccg tcctcgcctg caaagcgggc tgcaaactcc
     1741 aatgcgtcct ggatctgctt gccggtgacc gacatcaggc aggccacgtt gccaaagggg
     1801 ctgacctgct tacaggtctt gaaggtccag tcgcctgcgg gcacatcggc gcggatgccg
     1861 ccgccgttca tgatggccac atcacagtgc agcttttcca cctcgttgaa gtaggtgtag
     1921 atgccgtcag ccacaaagtc gccgaggttt gtctcggcag agcggatgcg gcgcttgccg
     1981 gtggcggggt cagagacgta gaaatcgctg tcgcccacag cgatcttctc gcccagcata
     2041 tcgtccacgg tgttcaccca gccagtctgc atggcggcga tgcctgcgtc catgccctcg
     2101 tgggtgggga tgagcttggt ggtaatggtg ccgtccgcag cgatggtcat ctcgccaacg
     2161 tttgcaaagt aagagccggt ctgggtcagg gtgacagcct tgccggaagc atcctgcacc
     2221 tgcttgttct ccattacggt atgggagtgg ccgtcgataa aggcgtcaaa gccgctggtg
     2281 tgggcaatga cttcctcact ggtccacgga gaggaagagg ggtctacgcc cagatgaccc
     2341 agaccgatga ccacgtctgc cagaagcttt gccttatcaa tggccttctg cacggcgtca
     2401 tagagctttt tgccgtcctc gccgccctga atatcgtaga tgtacttgcg ctgtgcctta
     2461 tccataaagt aggccggggt ggacttggta aaggtctcgg gggtggtcac gcccacaaag
     2521 gcgatgcgtc tgccgccgcg cacgaacacc ttgacagagg gcagcacacg cagcgtagtg
     2581 cgcaggtcta cccagttgca ggacaggtac gggaagtcgg cttccttcat gatggccttg
     2641 gcgcggtcca taccgtagtc aaactcgtgg ttgccggggg tggcgacatc gtaaccggca
     2701 gcgttcatca gcttgatgat ggaagcaccc tcgtccatgg agccgtaggc ggtgccctgc
     2761 acatggtcgc ctgcatccac cagcagcaca tccttgccgg cgttctgata gctctgcttc
     2821 aggtcggcaa tggcggcgta ggtcagcttg gggctctgct tgtcgatgta ggtatggaca
     2881 tcgttggtgt acaggatggt gacgtctgac ttatcaccaa accagcaggc cgatgcggca
     2941 ggcgcaccga tggccatgga tgcagcggca gcggtcacac cagcagcctt taaaaagctg
     3001 cgacgggaaa taagttgttt cacaggaaaa cgacctcctt ttatttttgg cgtatcgcat
     3061 ttgaggcagg ctcttccctc ctgccctttc aatagctcta gcatagcaca gaacaccgcc
     3121 gcaaacaagc caaaatcatt cttttggaac aaattatttt cacgtttcgc tttattttgg
     3181 cacacattgt accattttta cacaaaaaag gcctccccgt gccctgtcgc agagcagcgg
     3241 agaggtcttt tttagggggt gttgacccgt tgccgggtct atcggaggag aaggaaatat
     3301 cagatagcgt tatactcctt gaggaacttc tcaaggtcgg tgccctcgat cttcttcaaa
     3361 gcttccttca gagccagacg cgggatcagc ggcagatcca tgtcggtgat cttcttgccg
     3421 tcgcgcagct tcacggtggc atcgatcaga gcgcgcacat cgtaggtgct gccccagacc
     3481 tcgggcacgc cgcggtcgat gttcagcagg gtgtacacag cttccatacc ggtgcgcatg
     3541 gagtactcgg tggtaaagat ggtatcgcgg gcggtctcgg caaactgacc gaggaaggca
     3601 aagttcacag caccctcggg cacaacatcg gggcggtcgc ccatggcacg gggcatgaag
     3661 aaggcgtcga tatagggcat catcacaggc acggtgttgg cgctgtgctc tgccagttcc
     3721 gcgatctgat cctcgggcac accaatgtgg tacagccact ccatgcagat ctcgcggccg
     3781 gtgcagtcgc gcatgggctt cttgacgtaa tcgccgggct tatcgctgaa caggccgtac
     3841 acccagacgc acagctggtt cttgggctga tccttgaact gctgctgacg gttcagcgtc
     3901 cagctgagca gccagctgga gtccttgacg gtgacgatgc cgccggtgac ggtatggccg
     3961 ctgaaggggt cgcgcttgca gatcttgcgg atatactgag ggattttgtc gtccagcgtg
     4021 gtgatggtgg cgctctccca gttgctcagt tccggctcgg agcagaactt ttccgggtga
     4081 ccgaaggagg ggtcctgtgc ggcgatcttc ttccacagat cccagccgtt gccgggctgg
     4141 atggtggggt cgaagccggt agccttatcc tgtgcaccca cggtgcagct ttccacgcag
     4201 ccgccgttgg tgatgaacag cagatcgttc tcggtcaggt cgatgttggt ggtctcgccc
     4261 tcgtgctcca cggtaacaga gcttgccagc ttgcggccct tctggatgtc gaacttcaca
     4321 tcggtgacct tggtattgta gtggaactgc acgccgaagc tttccagata gcgcaccatg
     4381 ggcaggataa tggattcgta ctgattatag cgggtaaagc gcagggcggt aaagtccggc
     4441 agaccgccga tgtggtggat atagcgcttg aggtacagct tcatctccag agcgctgtgc
     4501 cagttctcga aggcgaacat ggtgcgccag tacatccaga agttggagtt gagcacctcg
     4561 tcatcgaaga aatcggtgat ctttttatcc tgcagctgct cgtccggggt aaagaacagc
     4621 ttcatgatct ccatggcacc cttatcggac aggccgaatt tgccatcggt gtgagcatcc
     4681 tcgccgcggt tgacggtggc gcggcacaag gagaagttgg ggtcctcctt gttcagccag
     4741 taatactcgt ccagcacgct ggcaccctcg gtctccagag acgggatgga gtgcagcata
     4801 tcccacataa cttcgaagtg gttgtccatc tcgcggccgc cgcgcatcac atagccgata
     4861 tcgtacttgt agccatcgca ggcgccgccg gccagtgcgt tcttttcaaa cacatggacg
     4921 tgctcgccct tcatctgacc gtcgcgcacc agatagcagg cagcggtcag cgcagccaga
     4981 ccggagccga tgatataagc ggatttatga tccacgccct ccggcttttt ggggtgtgca
     5041 aaagcttcat aattgccact ggaatagtac ataaaaaagc ctccctgctt caaaaatatc
     5101 ttttcacagc cttcatcgtg ctgttctcta tggcaacagt ataccccgca aagtgaaccg
     5161 gaacaacaaa caaactttgc ccggtgtata gattttttac atccgccctc atttgctgga
     5221 aatgcgtaca aattgtgaca taaagcgcag cgcaaaatca tttaaaacac tccctcaaaa
     5281 gtgcaatgcc gggcagcccg caggctgccc ggcattgcac taatttaaaa taattttccg
     5341 ctattcatgc ccagagcata gcggcgggca ttcaaaatcg tccccgcgca aaaagagagc
     5401 cgccacacaa ggttctgtgc agcggctctc cggtggattt tagttcatct gttccagagc
     5461 ctttttcagg ttctttgcaa tctggtccgg gcagctggtg ctgcggaagc cgcacagcgt
     5521 gccgtccaga cgggcaatgg catcctctgc cttcatgccg gtaagcagct ggcagatgcc
     5581 cttcaggttg ccgttgcagc cgccgacgac ctcaatggaa gcaatggtgt ggtcatcgtt
     5641 cagcacaaag ttggtctgct tggagcaggt acccttgttc gggaaggaaa attccttgct
     5701 catagtcttt acgtcctctc tcttttacgt ttttcggcga tggcgcgcag ctgcgctaca
     5761 gcctcgtcgg gtgcggtaca ggtgccgatg gggtgcgggt gcttgtggtt gcggccatgg
     5821 aagtccgtgc ccgcagtagc cacaaggccg tactgtttgc acagggcaag gcactcggcg
     5881 ctgtcctccg ggctgttgct ggggtggtac acctctatgc cgtccactgc gccctctgct
     5941 gccagctccc gcagcagggg catactttta tacaccgtgg ggtgggcaaa caccaccgcg
     6001 ccgccgcttg ccttggcggt agccagcacc tgccgcaccg gcagatactc cggcgaatgc
     6061 agcacgatgc cccgggggtt ccacccgaac agcttgtggt aggtctcgcc gtagatgctg
     6121 ccatcggtca ggcccagcag ttccagtgcc tgcatcagcc cgcttttgaa cagcacccca
     6181 ctggcctttg tggtctccca tgcaaggtcg gtggtaaact gcgggtacag ctgctccagc
     6241 tcctttgcgc tctgcaaagc gcaggcgttg cggcgctcct tcatgatggc gcaatgctcc
     6301 cgcagcgccg ggcagtccac gtccgggtag tagcacagca ggtgcacccg gtgctgccga
     6361 tcaaagtcat agccggtcag ctccacggcg ggaatcagct ctaccccgtc ctgcccggtg
     6421 tgggcatagg cgtactgggc gctgagcagg gtatcgtggt ccgaaagggc gatggcgtgc
     6481 agcccggtgc gggcagcgat ggacgccagc cgctcgatgg gcacagcacc gtctgagcag
     6541 gtggaatgga tatgcaggtc acaggacata gcgggttact tccttagtgc ttatagaaat
     6601 tgatcaggca gccatcagcc aggatctggc gctcgtcggt ggtgagcgga gccatgtaca
     6661 gctcaaactc cttgacggta tcgcccagaa cgtaggcctt gatgttctgc aggtcgccct
     6721 tgagtacttc ccgcacattg gggatgagca catagtcccc cagaccaaag ggggtggcac
     6781 ctgccagctg caagggcagc ataccccagt tgatgaggtt agagcggtaa cgcttggtag
     6841 cgtactcggt aacgatattg gcaccggcac ccagcacacg ctggcagctg gcggcctgct
     6901 cacgggcaga gccatcgccg ggcttgaccg caaagatggt agaggcaatc tggatatcgt
     6961 tccagttcag ctgctcgcag ccgggcacgg cgttcacctt tgccagcaga gcagcatccc
     7021 ctgcaccggc acggcgggcg ttctcttcgg cctgcacagc cttggcgcgg cccacatact
     7081 ccgggtcctt gcggctgagg gtgaactcgg ccagacccag ggggttagag cggtaagaag
     7141 aggtctcacc ggaggggatc agctcgtcgg tggtggtgac ggggtcggtg atataagaag
     7201 ccaccttcag cagcaggttg tcgcccagcg gtgcgatctc cggccagtcc ttgatgttgg
     7261 ggccgaactt gagcagggcg tcgtaatcgc ctttgccaaa gccctgatac acgcgggtgt
     7321 cgtagctgga agcatcgtac tggtactccg gcacggtggg atcgtaatca acgtcggtgg
     7381 caggggtcag gatgccgccg tttgcggtgg tggctgcaat gctgcgggca tccatcagtg
     7441 ccacaccgga cagctggccg ctgccgggct tggagccctc gcggctgggg aagttgcggg
     7501 tggtgtgacg gatggacaga gcgccgtttg cgggcacatc gcctgcgccg aagcaggggc
     7561 cgcagaaggc ggtgcggatg gtagcgccgc tggccatcaa ctcgctaatg acgccggtgc
     7621 gcaccagttc catcatgatg ggctggctgc cggggtaaac gctcagagcg tagtcgccgc
     7681 agccgccggt atgacccttg aggatggaag cagcctcgta gatgctgtcg tacagaccgc
     7741 ctgcgcagcc tgcaataacg ccctgatcca cccgcagctt accgttttcg atcttgctgc
     7801 acaggtccag ctgcacgtcc ttgcggccga tcagcttctg cacatcctgt tcgcaggcgt
     7861 ggaggatgtc ctccaggttt gcgttcagct cctcaatggt aaaggcgttg gaggggtgca
     7921 tgggcagggc gatcatggga cggatggcgg aaagatccac ctccaccacg ccgtcatagt
     7981 aggcaaggtc tgccggtgca agctttttat agtctgctgc acggccatgc actgccagaa
     8041 aacgctgggt gacttcatcg gtctcccaga tggaggacag gcaggtagtc tcggtggtca
     8101 tggcatcaat ggcgttgcgg gtatcctgcc gcagggaggc aatgccaggg cccacgaact
     8161 ccatgacctt gtttttgacg tagccgctct tgaacagctt gcccacaagg gcaatggcta
     8221 catcgtgggg gccgcagccc gccggcagac tgccggtcag gtagatggcc accacacccg
     8281 ggcgggcaac atcataggtg cggcccagca gctgctttgc cagctcgccg ccgccctcgc
     8341 cgatagccat ggtgcccagt gcgccgtagc gggtgtggga gtccgagcca aggatcattt
     8401 tgccgcagcc ggcaaagcgc tcgcgcatat actggtggat gactgccatg tgcgggggca
     8461 caaagatacc gccgtacttt ttggcagcgg acaggccaaa gcggtggtcg tcctcgttga
     8521 tggtgccgcc cacagcgcac aggctgttgt ggcagttggt aagcacataa ggaatgggaa
     8581 acttttccag cccggaagca cgggcggtct ggataatgcc cacaaaggtg atgtcatggc
     8641 ttgccatggc atcaaacttg atcttcaggt tctcgacatc gccgctggtg ttgtgtgcct
     8701 gcataatatt gtaggccatg gtaccggtct tagccgcggc aacggcagcg gcatcaaagc
     8761 cctttgctgc cagtgcagcg ggtgcattgc catctgcggg cacccactct ccgtgcgcat
     8821 agtacgcacc gccggtgctg catttgatca tatccaacat ctcgattcgc ctctcttttt
     8881 gtattttccc gcccgccgca attgcgggca ttgccccggc agtgcggggt cacccctgcc
     8941 ctgccctgtt acggcaaagc cgtatttact tgttattata gcatgaaagg gcgaaaagaa
     9001 aaagcatttt ttatgaaccc ttactgcacc tttgcggcgg cttcctgctg cttttccttt
     9061 tgcagtctgc ggaacaccac aaaataggcc gggatcagga agaagcaggc aaagagccat
     9121 gccaccgggc ttgcgatgca ggcggcaaag tagccccaca gcggcacgaa ccagaagccc
     9181 accatggcgc gggcgatcat ttcagccaca ccggcaaaca tggcaaggcc ggagtgtccc
     9241 agaccctgaa tggtgtagcg gtagatgata agcactgcca gcgggatgta gaacacactg
     9301 ttccagaaga tgaagtcctg cgcattggcc ataatggcgg tctcgcctgc gtccaggaac
     9361 aggccgatca ggggcttgtc cagcacgcgc aggatgagga aggaggccac gctgtacacg
     9421 cagccgatgc ccagtgcggt gttcacgccg cggttcacgc ggcccagatc cttcgcgccc
     9481 atattctggc tggtgtaggt ggtcatggcg gtgccgatgc tctccagcgg cacgctgagg
     9541 aactgcgcag ccttgccgcc ggcggtctgc gcggctacga tatcgctgcc cagaccgttc
     9601 accgcgccct gcagcaccac gctgccgatg gcagtaatac tgcactgcag acccatgggg
     9661 aggcccatgg cgcaaagctt tgcgcagtgc ggagcgctga tgcgcccttc ttccttattc
     9721 cagcgcagtt ccgggtagtg gcgcatgatg taaataaggc tgccgatgcc tgccacagcc
     9781 tgactgaaca cggtggcaaa agccgcgccg aacacgccca tgttgaacag gatgatgcag
     9841 gcaaggtcca gcccgatgtt cagcacgctg gccaccagca ggaaatacag cgggcgcttg
     9901 ctgtcgccca gtgcacgcat cagggcgctg gtcacattat aaagcagcgt gaaggggatg
     9961 cctgcaaaaa tggtgcggat atagatatcc gcaaggtcga tgatatcggc cggggtgttc
    10021 gtccacacca gcaccagatg ggtcattgcc accgtaacga tggtgagcac cgtggcaaaa
    10081 gcgatggaca gccacacggt attggcggtg tagcggcgca tctcgtggtg gtcgtgggca
    10141 ccgaaggtcc atgagatggg gatggaaaag ccgcaggcaa tgccgttgac aaagcccagc
    10201 accagatagt tcaggccgcc cacgctgcct accgctgcca gcgcttccac gcccacgaac
    10261 cgccccacga tgatggtatc ggccagattg tagaactgct ggaacaggct gcccagcatc
    10321 agcggcacag caaaggcaag cagcagcttc agcgggctgc cctgcgtcat atctttggtc
    10381 atggaaatat acctcctgcc cacacaaaaa agatggatgt tcgcattttt gccgtgaaaa
    10441 acgccctgcc ggaaaagcgg caggacgttg ataaagattc atgagtggta ttatagcgg
//
