LOCUS       gnlProkkaHDKMOJKM_28   13574 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDKMOJKM_28.
ACCESSION   gnlProkkaHDKMOJKM_28
VERSION     gnlProkkaHDKMOJKM_28
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 07:40:11
            Original ID  :: gnl|Prokka|HDKMOJKM_28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 10125
            Orig. end    :: 23699
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13574
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8574]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8574
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13574
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13574
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3252..4067
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="MELATEALSYNNQNIASEAPKLLLCSSIASVSDQGSNKGVTPLAG
                     IGKEHPELNWYYLYLPNKELKRYIGVFSGRKSVKLRKPSGEAEERYFCFKVFSYTSADH
                     RKRFEQCAYTKEEYTARRDSARVVKEAFATGSARKLNALTDEKEIEGNGWLFVCAPLDQ
                     LELILSAMFPRQYLVTDYNTHCAAVIPQRQMEEFIYLYESMPYNIELMNRPLEDYLQKK
                     QRIRITGGVFRGKEGCIMRLHRNTRLVFAFGNMTVAVSYLHAFPFEKVE"
     CDS             5001..6323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 207.8;
                     E-value: 3.3e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_12"
                     /sec_met_domain="CTP_transf_like (E-value: 1.6e-15,
                     bitscore: 49.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1e-119, bitscore:
                     390.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 9.7e-64, bitscore:
                     206.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENSKKVYVGMSADMIHPGHLNIIREAAKLGCVTVGVLTDAAIAS
                     YKRLPYLDYNQRSEIVRSLKGVDNVVPQETLDYVPNLERLKPDFVVHGDDWMQGVQSNV
                     RNRVIECLKQWGGKVVDIAYTKGFSSSAENERLKEIGTTPEIRQKRLRRLINAKKIVRI
                     LESHNGLTGLIAENVSVIVNGVKHEFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLND
                     TLECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKVGLKQNSLFGTDAVQIQ
                     DTIEGFCNKIRTGKNAQVSDDFMIIARIESLIAGKSIDDALARAAAYVEAGADGIMIHS
                     KNKSGDDIKEFCQRFRVANVSTPIVVVPTTYSHITETELASWGVNVVIYANHMLRSAYP
                     SMVNCAKSILMHERSQEAVNDYCMPIKEILELIPGTKKTLK"
     CDS             6320..7459
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 53.7;
                     E-value: 2.5e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_13"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.8e-19, bitscore:
                     61.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-17, bitscore:
                     55.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPDFFINSLSQRGIDFFAGVPDSLLKNICAYIADHKDGHHNII
                     AANEGAAVGLAAGHYLATGHIPVVYMQNSGEGNIINPLASLTDKDVYSIPLLLLIGWRG
                     MPGVHDEPQHVKQGKVTIPLLDVMGIKHVVMSKDEKELLKQIEDALFFMETKNEAFAFV
                     IEKDTFDSYELQSGSTSTLSMSREETIQAIASSIGQEDCIVSTTGMISRELFEHRTQMK
                     QGHEKDFLTVGSMGHASQIALGIALEKTDRRIWCFDGDGAVIMHMGSMAIIGSKQPKNY
                     IHVVFNNGAHDSVGGQPTVGLDIDLPGIARSVRYNAVHTVSDMNGLKKVLSDIRLEDGP
                     VLLEVKVRKGNRKDLGRPTTTPIQNKEAFMGFLQDKELN"
     CDS             7462..8574
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_14"
                     /sec_met_domain="Fe-ADH (E-value: 1.7e-71, bitscore: 232.4,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEYYIGPDLNTQLAALLQKLNVTKVFLVRGKKSYTSCGASDVMD
                     AVLSGRGIKTVCFFDFLTNPRVEDVRKGVLLCKSQCPNIILAVGGGSALDMAKLIRYHI
                     YKETDSYIPLVVIPTTAGTGAETTHFSVCYINGEKQSIADSAMLPDYAFVCSELTSHND
                     AYLTACTGFDAVAQAIESYWSVNSTDESRSYSLKALGLLWKQLPLLIKNLDNKELRSEV
                     AEGAYYAGRAIDITTTTAPHAFSYKFTSLYGIPHGHAVALTFPYFFALNLYGERLQSTL
                     DSYEYGQRMKLLVQFLDADRSDFLSCQLHMSTYISSLGLSAKALTFDELASAVSSFNEQ
                     RGRNNPVVIDEEVKSGLQNYFMELKESDKE"
     CDS             8611..9330
                     /locus_tag="ctg28_15"
                     /transl_table=11
                     /translation="MRIQNLYYKLGGKKGGFLQTKWSGYIQKKTVKRNRKLLQDKGICA
                     LDAMSAACKEAGVSFGMEFGTLLGAYRNQGFIPYDDDMDLTMWAEDCSRDFENVLLKYG
                     FYKKRAFYLVTVDSNGKRTRKLTEIALDYDGLQVDIFFSFRKTEITRSIFVYCPPVVNE
                     KMTAREFVLPIGLSPRLVTVRNKQYPAFADPHKTLSLIYGEDFMIPRKNASATKSIQSN
                     VIIHDMFVAYGEGFMLE"
     CDS             complement(9597..9740)
                     /locus_tag="ctg28_16"
                     /transl_table=11
                     /translation="MHKEFNKTLTPDILINKDKRGSLNQSAINGEPIHNIQYANMPINT
                     LK"
     CDS             9754..10779
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_17"
                     /sec_met_domain="Polysacc_synt (E-value: 3e-17, bitscore:
                     54.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTANLDIRRQTIINLCGQIPAGLITAILAYNGLGVYALVFQTII
                     ASCIRVIMLWLYTPWRPQEKFNRESFLSLWNFGSKLLGANLIGTAFNQVSSVLIGKYIG
                     KSDLGYYSKASNLCGNIDSVSSGVVQKVALPMLSEFQKDKVLLSEKFREMMRLLIMGMA
                     PLISFFCFTASDIIVILWTEKWIQCAFVFQILIVGAAFNPIGHMSLSLMQTVGNSALIF
                     KLEVPKKIIYCIYLAIGFCYGLVGLAVAQVLINITGALINMWATKRIVKYSYMRQIVDV
                     LGYMVIAFIVGYIWFNMIHTGYMFFNILLMFMLIVFTYFAILVMIKDAILIKYVRKIIG
                     L"
     CDS             10983..12263
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_18"
                     /sec_met_domain="Wzy_C (E-value: 2.2e-08, bitscore: 25.8,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIICVFIFLIISLLLIVNFKCTFMVVSACSMVLGCMNGVGPFGM
                     YQAVSIAAFSIFMLRYFYWKDMRTYPLLFSSILLIVSYVLSNHYAVYRHYGSLVSCIVV
                     DVASLFVFYQIISKNSRYIFIYIRTCVILSLVVGVYTLVETIISSNHYMFIVNSLELYS
                     QDIIVEDIRFGMKRAQAIFGMHTTLGGFSTMMAGLLLWVRLNCTLYVKKLGKKKLSIAI
                     GLMIIAVFLTGTRSTIAGLAVVLMSFFSFKHVKMKYVFIAIVSVVIGFMALDAYLDKII
                     LSFTDTESVGGSNTDMRSIQFELAALFMMQSPFLGNGISYTFEYVADKYKEMCGAESLW
                     IPIMIDFGMLGITAIIVFIIQVGYYIKKYCEIRLLFFLLGILVFNSLSSIPAFSFTQLF
                     YLFVIIAFLKKHQVSICNSPSSSPSIK"
     CDS             12227..13210
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_19"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.1e-34,
                     bitscore: 110.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLSIIIPVYKVEKYIRDTLQSIYRQQYDENLFEVIVINDGTPDD
                     SMRIVAEFTNKHANLHIINQKKQGLSCARNAGLKIAQGEYVWFVDSDDTVTEESIGKVI
                     ECIERSKADVIGFSILKVSEANRVSEVESAIWNEHCRFSSNQIVCDKSILFSLHTGAAV
                     RYVYRRAFLQMNHLRFYPGILYEDQEFLPRVFSLANSFYISSFISYRYLLRSSGSIMSQ
                     FSLRSLRDTLTIVRSYETWLQEEIKGKSALINAYINGCIFNHTYWLLSFKAVTFRDEQK
                     EFMRDHYVEIRRKCLTAGWKSLKGNFRLTRAVRLLMVFLIPHHLIK"
ORIGIN
        1 tcgtgtgcaa agtacttttc atgaggggga agctctgacg gatgattggg cgactagttc
       61 atttggatat ggttcggcca tgcaggaaaa tctggcggga attgaggatt atacccgtgt
      121 gggatgtatt atccaaccgg agcaattggt aaaatatggt gaattgtgtt tgcgtgagaa
      181 tgaaatagct tacgctgatc ccggtttctt ccgtctgttt gattttgaat tgctgaaagg
      241 cgaccgcacc tcttgtcttt ccatgccggg ccaggttgtg atcacggaac ggattgcccg
      301 taaatatttc agagatgaag accctgtcgg gaagatactt atctttaaca gtaatatggg
      361 aaaaatgtct tgtgaggtaa ccggagtcat gaaaggaatg ccttctaatt cgcatataca
      421 ttataatttt cttttatcat atgccacctt acctaaatgg gtacaggagt attggtataa
      481 acatgaagcc tatacatatg tattgctgga ttcgcccgag cgcaaagaag agatagaacg
      541 tgcttttcct caattggccg agaagtataa aactgaagag gcattgaaaa acaagacttg
      601 gggagtgagg ttggagccat tggagaagat tcatcttaat cctcaattag gttatgaggc
      661 cgagttgaaa gggaaccgtt cggccattat cgcattgatt ttcggagcta ttgctatttt
      721 gattatcgct tggatcaatt atataaacct gacagttgcc cgttctatgg agcgtgcaaa
      781 ggaggtgggg gtgcgcaggg tagtgggagc tttcccgaaa cagcttgtca atcaattcct
      841 tttcgaggca tttgtaatga atctgattgc ctttgtcata gctctcgggc taatcgaatt
      901 attacttcct gcattcaatc agttggtagg acgcaccatc actttctcgg tatggttcac
      961 cgaatattgg ggcattttag tcttgctgct ttttgtagcc ggtatttata tctcgggtta
     1021 ctatcccgcg cgtgcgttgt tacgcaaaaa gccgattgta ttgttgaaag gtaagtttca
     1081 gaacagtcgt gccggagaga atacacgtaa aatattggtt attgtacaat atacagcctc
     1141 catgatattg ctttgtggta cactgattgt ttttgcacaa ctcaattaca tgcgttgcca
     1201 gtctttgggg gtaaagaccg atcagatttt ggtaatcaag tttcccgggc ctaccgaggg
     1261 aatgaaaaca aagatggaag ccatgcggaa agcgatcaga aagttgccgc tggcttcaaa
     1321 agtaacttgt tccggagctg taccaggtga agaagtagcc atgtttttat ccaatcatcg
     1381 tgcgcatgat gcattgaagc agaaccggtt gtacgaaatg ttaagttgcg accctgacta
     1441 tatagatgca tacggactgg aggtggtagc cggacggggt ttttccgagg aatatgggga
     1501 cgatgtgaat aaattggtta tcaacgaaac agccgcccgt atgttaggat atatggataa
     1561 tgatgatgcc attggtgagg aaatagctgt tgaaacggta ggagagccca tgcaggtaat
     1621 cggggtagtg aaggattatc atcagcaagc gttgaataaa ggttatacag gggtaatgct
     1681 tttccataaa gataagattg actggattcc tcagcgttat atttcggttg tgatgaaacc
     1741 gggtgatcct tcggaattag tatcacagat aggagaaata tggaataatt actttgcgga
     1801 ttccagtttt gattatttct tcctcgacca gttctatgac cggcagtacc gtcaggatga
     1861 ggctttcggc gtattgatgg gaggttttac cggattggct atttttatct cctgcttagg
     1921 tttatgggtg ttggttatgt tctcttgtgc cgtccgtacc aaggagatgg gcattcggaa
     1981 agtattgggg gcatctcgtt ggaatttgtt ttatcagttg ggtaaaggtt tctttattcc
     2041 tattattatc gctattctga ttgcgttgcc tgtggcatgg ggcagcatga atgcatggtt
     2101 ggctcattat ccgttccgaa cagaattgaa agtgtggttc tttctgcttc ctgtggtctt
     2161 gatgttgttg atttcttttc tgactgtagc aggacaaacc ataaaggttg tttatagtaa
     2221 acccgctcgg tcattgaaat atgaataatg gaatataaga tatccgtggt tagtaattca
     2281 tttacaagga atatcattta aaaccaatat aaattatcgt accagttcat tatggcagat
     2341 caatactgat aaactttgaa aaccttttga atttttctac aaaactaatt ttgtatctaa
     2401 aattatttta ttaattttac agcgttttta aggagagtct aactctctat agttacaaat
     2461 gagcgatgag aaagggtgcc ctgatggcat cctttctctt ttgtagtgtg tttttgtata
     2521 atctatattg tattttactt atgtcacgat tatgtgaaat cacgatacat cttttgtatt
     2581 tccgtttctt ttacttttat cagacttaat cgtttttctt gcattaaaaa acaattggac
     2641 ctccctttgt tatatattta acactctttt aatctcattt tgttgaacaa tctacgcgat
     2701 tcaaatgtta atataatgtg tttttcatag taatagattt aagattaata gttagtattt
     2761 gcttgtgaaa gtcagtacac ttacggataa aagcgtttat ccgaaaagaa aagagaggcg
     2821 accggaaacg gaagcctctt tctttttgag catttttagt tcaccataat tattgtgaga
     2881 ggaaaattga ttctgattgt ataaataata taatgtgttg aaaataagat ttttcccttt
     2941 ttaagccttt aataaaaaat ggagttctct tagtaagaga accccatttt gctgcaaaga
     3001 tagctataat tccttaatac agaaaattcc gcattaaaaa agtattccaa agtatgctta
     3061 taaatgacaa ttgtttgcaa aaataatatg aaaggttata actataggac actctatcag
     3121 gcatttaagt aaacttgggg ttctcttact aagagaaccc caacaaaaaa acgaacattg
     3181 atggcttatt cgagcctcat tttttagaag aataatttaa ttatgatgtt ttgatggaaa
     3241 taaaaagtcc tatggagctt gcaaccgaag cactctctta taataatcaa aacatagcga
     3301 gcgaagcgcc taagttactg ctctgcagtt caatcgcttc cgtctcagac caggggtcaa
     3361 ataagggagt cacgccattg gcgggaatag ggaaggaaca tcctgaactc aattggtatt
     3421 atctgtatct gcctaacaaa gaattgaagc gctatatcgg cgtttttagt ggcaggaagt
     3481 ccgtaaaact tcgtaagccg tcaggtgaag cagaagaaag atacttttgt ttcaaggtat
     3541 tttcctatac ttcggcggac cacaggaaac gcttcgagca atgcgcctat actaaggagg
     3601 aatatactgc ccgtcgtgat tccgcccggg tagtgaaaga agcctttgcc accggttccg
     3661 cccggaaatt gaatgctttg acggacgaga aagaaatcga aggcaacggc tggctgtttg
     3721 tctgcgctcc tttggatcag ttggaactta ttttgtctgc tatgtttcct cgccagtatt
     3781 tggtgacgga ctataacacg cactgtgcgg cggtcatccc tcaacgtcag atggaggaat
     3841 ttatctattt gtacgaatcc atgccttaca atatcgagtt gatgaaccgt cctttggagg
     3901 attatcttca gaagaaacaa cgcatccgga ttaccggtgg cgttttccga gggaaggagg
     3961 ggtgcattat gcggctgcat cgaaatacaa ggttagtgtt cgcttttgga aatatgacgg
     4021 tggctgtgag ttatcttcac gcttttccgt ttgagaaggt tgagtgaaga tagtttctgt
     4081 tcttgtgctc atcttttatt gaaataagca ttattgagca aaataatatt tgaatttgct
     4141 tggatatatg atgaaaaatc atgttccttg caaaattaac tcatacttat ggcaaaacag
     4201 ataactccta ctcctccctt gaaaggggca ggccgcaatt gatttcatta cggaaatcag
     4261 caaaaaaaga aggtcaccca gcagaaaagg ctaaggtgaa agagggggca tgcgcataaa
     4321 ggcgttgctg acctttaatt tctagcactc gtatgaataa agatattcgg gtaatttgct
     4381 tgtcagaaga ttatgaattt aaaccgtttg actgtggaaa tgatgatctg aatggtttct
     4441 tgttacaaga ttattggatg atgaggaaca gccgatagat aacctagggg agtgagccat
     4501 tcgaaaattt actactcaac gaaacaattc actttattac ggtagtgatg ccggtgctga
     4561 aatggctgcc acatatcatg gtgtgattgg aacggtgaag cttttgggta gctctatctg
     4621 gaatttcatc ggaatttttt tcaaaaatat ctttaacgga tgcagggagt atgttaatat
     4681 ggttcctgac aaaatcactt tggctacaag ttaatgttaa attcaaagct gattaattaa
     4741 cagaactcag tttagggcac agttatgtgc ccttttaaag ggggatgctc taaattgagt
     4801 gcttagagat ggtaagagtc tctgttgaat atcatcatct caacttgcaa aatgtatttg
     4861 tactaagaaa ctaaaatata tttagcatta ctttccttta ataacagtcg tatgactaaa
     4921 gttcgttgca tattaaacga tgatatctac atacatgatg ctggatatgt aaaaatgtaa
     4981 attcaaattc aatcaattat atggaaaata gtaagaaagt ttatgtgggg atgagtgcgg
     5041 atatgataca tcctggtcat cttaatataa tccgcgaagc ggcaaaactt gggtgtgtaa
     5101 cagttggcgt gctgacagat gctgctatag caagttacaa gcgtttacct tatcttgact
     5161 ataatcaacg atcagaaata gttcgttcct tgaaaggagt ggataatgtt gtccctcaag
     5221 aaacattgga ttatgttcct aatcttgagc ggttgaagcc tgattttgtt gttcatggag
     5281 atgactggat gcagggagtc cagtccaatg ttcgtaatcg ggttatagaa tgtctgaaac
     5341 aatggggagg aaaagttgtc gatatagctt ataccaaagg cttttcttct tccgcagaaa
     5401 atgaacgtct gaaagagata ggaactactc ctgaaatccg tcagaaacgt cttcgtcgtt
     5461 taattaatgc caagaagata gttcgcatat tggaatccca taatggcttg accggtttga
     5521 tagcagaaaa tgtatctgta atcgttaatg gcgttaagca tgaatttgac ggtatgtggt
     5581 caagttcatt gacagactct actagtaaag ggaagcctga cattgaagct gtagatttga
     5641 ccacacgttt gcatgacttg aacgacacgt tggaatgtac aacgaaacct gtcatattcg
     5701 atggagatac gggcggtaaa attgaacatt ttgtattcac agttcgtacc ttggagcgct
     5761 taggaatttc tgctgtcatc atagaagata aggtaggttt aaagcagaat tctttgttcg
     5821 gtacagatgc ggttcagatc caagatacta ttgaaggatt ttgtaataag atccgtacag
     5881 gaaaaaatgc acaagtgtcg gacgatttta tgataatagc ccgtattgaa agcctgattg
     5941 ccggaaaaag tatagacgat gcactggcgc gtgcggcggc gtatgtggaa gcaggtgcag
     6001 atggcattat gattcatagc aagaataaaa gtggggatga tattaaggaa ttttgtcaaa
     6061 gattccgggt tgctaacgta tctactccca ttgttgtagt acctactact tacagtcaca
     6121 taacagaaac cgaattggct tcatggggtg tgaacgtagt aatttatgca aatcacatgt
     6181 tgcgaagtgc atacccctct atggttaact gcgccaaatc aatccttatg cacgaacgct
     6241 cacaggaagc tgttaatgat tactgtatgc ctatcaagga gattttggaa cttatacccg
     6301 gaacaaaaaa aacactaaaa tgatttcacc tgattttttt attaatagcc tttcccagag
     6361 aggcattgat ttctttgccg gagttcccga ttcattgctg aagaatatct gtgcctatat
     6421 tgcagatcac aaagacggac atcataatat cattgcagct aatgagggtg cagctgtagg
     6481 tttggctgcc ggacattatt tagctaccgg tcatatacct gttgtctata tgcagaattc
     6541 cggtgaagga aatatcatca atccactggc gtcgcttacg gataaagatg tttatagcat
     6601 tccactcttg ctgcttatcg gatggcgagg aatgccaggt gtgcatgatg aaccacagca
     6661 tgtcaaacag gggaaagtga ctatcccgtt acttgatgta atgggcatta agcacgttgt
     6721 gatgagcaaa gatgaaaaag aattgttaaa acaaatagaa gatgccctct tttttatgga
     6781 aacaaaaaat gaagcttttg cttttgtgat agaaaaagat acattcgatt cgtatgaatt
     6841 gcaatcaggc agtacttcaa cattgtcaat gagtcgtgag gaaaccattc aggcaattgc
     6901 ttcatctatc ggtcaagaag actgcattgt gtctactact ggtatgattt ctcgtgagtt
     6961 gtttgagcat cgtacccaaa tgaaacaagg tcacgagaaa gattttctca ctgtaggttc
     7021 catgggacat gcttctcaaa tagctctagg tatagcattg gaaaagacag accgtaggat
     7081 ctggtgcttt gatggcgacg gagctgtaat tatgcacatg ggttctatgg ccattatagg
     7141 gagcaaacag ccgaaaaatt atattcatgt agtctttaac aatggtgctc atgattccgt
     7201 aggtggccaa cctacggtgg gcttggatat tgatttgccg gggatagccc gttccgtaag
     7261 atacaatgcg gttcatacgg tttctgatat gaacggtttg aaaaaagttc tgtcggacat
     7321 tcggttggag gatggtcctg ttttgctgga agtgaaagta aggaaaggca atcgtaagga
     7381 tttgggccgt cctactacca cgcctataca aaataaagaa gcttttatgg ggttcttgca
     7441 agataaagag ttgaattaat tatgcaagaa tattatatcg gaccagactt gaacactcaa
     7501 ttggctgctc ttctgcagaa actaaatgta acaaaggtgt tcttggtaag aggcaagaag
     7561 tcctatacat cctgtggtgc atcggatgtg atggatgccg tattaagcgg aaggggtata
     7621 aaaactgtct gtttttttga cttcttgaca aaccctagag ttgaagatgt caggaaaggg
     7681 gttcttctat gcaagtcaca atgtcccaat atcatattgg cggtaggcgg tggcagtgca
     7741 cttgatatgg ctaaactgat tcgttaccat atatataaag aaacagatag ctatattccg
     7801 ctagtggtta tccctacaac agctggaaca ggtgcggaaa caacccattt tagcgtgtgt
     7861 tatataaatg gggagaagca gtcgatagct gattctgcaa tgcttcccga ttatgctttt
     7921 gtctgttcgg agttgactag ccataatgat gcttatctga cagcttgtac aggatttgat
     7981 gctgttgcgc aagctataga atcctattgg agtgtgaatt caacggatga aagccgtagt
     8041 tattcgttga aagcattagg tctgttgtgg aagcaattgc ctttgctgat aaaaaacttg
     8101 gataataagg agctaagaag tgaagtcgca gaaggggcgt actatgcagg tcgtgctatt
     8161 gatataacga ctactactgc gcctcatgct ttttcttaca aattcacaag tctgtatgga
     8221 ataccgcacg gtcatgcggt ggcactaact tttccatact tttttgcatt gaatctttat
     8281 ggtgaaagat tacaatctac attggatagt tatgaatatg gacaaagaat gaagttgttg
     8341 gtacaatttc tggatgctga tagaagtgac ttcttgtctt gtcagctgca catgagtact
     8401 tatatttctt cattgggttt gtctgcgaaa gcattaacat tcgatgaatt agcttctgct
     8461 gttagctctt ttaatgaaca aagggggcgg aataatcctg ttgtcattga tgaggaggta
     8521 aaaagcggat tacagaatta ttttatggaa ttaaaagagt cggacaaaga ataggttgat
     8581 cctagccatt tccaatttaa attattaatt atgcgtattc aaaatttgta ttataagcta
     8641 ggggggaaaa aaggaggttt ccttcaaacc aagtggagtg gatatataca aaaaaaaacg
     8701 gttaagagaa atagaaagct attgcaggat aaaggaatat gtgctcttga tgctatgtcg
     8761 gcagcctgta aagaagctgg tgtcagcttt ggaatggaat ttggaaccct gcttggagcc
     8821 tatcgtaatc aagggtttat tccttatgat gatgatatgg accttaccat gtgggcagaa
     8881 gactgttcta gggattttga aaatgtacta cttaaatatg gtttctataa aaaaagagct
     8941 ttctatcttg taaccgtaga ttctaatgga aagagaacaa ggaagctgac ggaaatagca
     9001 ttggattacg atggattaca agttgacata ttcttcagtt tcagaaaaac ggaaataaca
     9061 cgctcgattt ttgtttattg ccctcctgtt gtaaatgaaa aaatgacggc tcgtgaattt
     9121 gtactgccta tagggctttc tcctcgatta gtgactgtaa ggaataagca atatccggct
     9181 tttgcagacc ctcacaagac tctttcttta atttatggag aggattttat gattccacgt
     9241 aagaatgcca gtgcgacaaa aagtattcaa tcaaatgtaa taattcatga tatgtttgta
     9301 gcttatggag aaggttttat gttagagtag tgtggttgta gacttttatt tctttccatg
     9361 aagagaacat cgggttttgt tgctgttatt tggagtttga ttgaacggtt gtcaagtcag
     9421 gtaataagtt tccttttggg tattgtatta gcgagattgt tgtcccctag cgattatggt
     9481 atcgttggaa tgacaatgat ttttatatta ttgtcaaatg tgtttattga agcaggcttt
     9541 gccaatgcat taatacgtaa aacaaatcga actgagcagg atttgtcaac agcattctat
     9601 tttaatgtgt tgattggcat attggcatat tgtatattat ggattggttc accgtttata
     9661 gctgattggt tcaaagaacc tcttttgtct ttattaatta ggatatcagg tgtcaatgtt
     9721 ttattaaatt ctttatgcat cgttcaaaca gccttgttaa cagcgaattt agatattcgt
     9781 cggcaaacaa tcattaattt gtgtgggcaa atacctgcag ggctgataac agctattttg
     9841 gcgtataatg ggttgggagt ttatgctcta gttttccaaa caataatagc ttcgtgcatt
     9901 agggttatta tgttatggct ttatactcca tggagacctc aagaaaaatt taatagagaa
     9961 tcttttctct ctttgtggaa ttttgggagt aaattactag gtgctaattt aataggaaca
    10021 gcctttaatc aggttagttc tgtgttaatt ggcaaatata taggaaaaag tgatttggga
    10081 tattactcca aagcgtcaaa tctatgtgga aatattgata gcgtttcatc gggagttgta
    10141 cagaaagtgg cattgcctat gttgtctgaa tttcaaaaag acaaagttct attatcagag
    10201 aaatttcgtg aaatgatgcg tttgcttatc atgggtatgg cgccattgat ttcttttttc
    10261 tgctttacag catctgacat tattgtaata ctttggactg aaaagtggat tcagtgtgct
    10321 ttcgtatttc agatacttat agtaggggca gcctttaatc ctataggaca catgagtctt
    10381 agtttaatgc agacagttgg aaattctgca ttaatattta aattggaagt ccctaagaaa
    10441 attatctatt gcatttattt agctataggt ttctgctatg gcttagtcgg tttggctgtc
    10501 gcccaagtat taatcaatat aacaggagct cttattaata tgtgggcaac aaagcgtatc
    10561 gtcaaatata gttatatgcg acaaatagta gatgttttgg gttatatggt gattgctttt
    10621 attgtgggct atatatggtt taatatgata catactggat atatgttctt taatatttta
    10681 ttaatgttta tgttgattgt gtttacttat tttgcaatac ttgttatgat taaggatgca
    10741 attttaatta aatatgtaag aaaaataatt ggactctagc tattaaacct gtttagatga
    10801 ttttttttct tctttcatat tcgtgcatca tccattgttt ctgtatcata gaaatgctac
    10861 ccattctatt tcagccccaa aggagtaata tccttggagt tagtatttga tgcggaagag
    10921 cacaaaaata acaatatgca atattatgcc atcaactata tgattaaata tacgattctt
    10981 ttatgaatat tatctgcgtt ttcatctttt tgataatcag tttactatta attgtaaatt
    11041 tcaaatgtac tttcatggtg gtgtctgcat gtagtatggt gttaggctgt atgaatggag
    11101 tgggaccttt tggtatgtac caagctgttt caattgctgc attcagtatt tttatgttgc
    11161 ggtattttta ttggaaggat atgcgaactt atccgctctt gttcagctca atattattga
    11221 ttgtatctta tgtgttgagc aatcattacg ccgtataccg tcattatggt tcattggttt
    11281 cctgcatagt ggtagatgta gcttcactgt ttgtattcta tcaaattata agtaaaaata
    11341 gccgatatat atttatatat ataagaactt gcgttatttt gtcgttggtt gttggtgtat
    11401 ataccttggt agaaacaata atttccagta accattatat gttcattgtc aattcattgg
    11461 aactatattc tcaagacatc atcgtagagg atatacgttt tggcatgaaa cgtgcgcaag
    11521 ctattttcgg catgcacact acgttaggag gtttctccac tatgatggct ggacttttac
    11581 tttgggtacg cttgaattgt acgctgtatg taaagaagtt gggaaagaaa aagctttcaa
    11641 tagctattgg cttgatgatt atagccgtgt ttcttacagg tacgcgtagt acgatagctg
    11701 gactggccgt agtgttaatg tcctttttca gctttaagca tgtaaagatg aagtatgtat
    11761 tcatagcaat tgtctcagtg gtcataggtt ttatggcttt ggatgcatat cttgataaga
    11821 taatcctttc atttaccgat acggaaagtg taggaggaag caatactgat atgcgttcca
    11881 tccagttcga actggcagct ttgttcatga tgcagtctcc tttcttggga aacggtatca
    11941 gctatacatt tgaatatgta gccgataagt ataaggagat gtgtggtgcg gaaagtttat
    12001 ggattcccat catgatagac ttcggcatgt tgggaattac agctattatt gttttcatta
    12061 tacaagtggg gtattacatt aagaaatact gcgaaattcg attgcttttt ttcttattag
    12121 gtatattggt gttcaactca ttaagttcta taccagcttt ttcttttacc caattatttt
    12181 atctgtttgt tataattgca tttttaaaaa aacatcaagt gtctatatgc aactctccat
    12241 catcatcccc gtctataaag tagagaaata catacgggat acattgcaaa gtatatatcg
    12301 tcagcagtac gacgagaacc tttttgaggt gattgtgata aacgacggta cacccgatga
    12361 ttctatgcgt atagtggctg aatttacaaa caagcatgct aatctgcata ttatcaatca
    12421 aaaaaaacaa ggattgagct gtgcccgcaa tgcggggttg aagatagccc aaggtgaata
    12481 tgtatggttt gtggacagcg acgatactgt gactgaggaa agtataggga aggtcattga
    12541 atgcatagag agaagtaagg cggatgtgat aggttttagc atactcaaag tcagtgaagc
    12601 gaatagagtg tctgaagtgg aatcagccat ttggaacgaa cattgtcgtt tctcatctaa
    12661 ccaaattgtc tgtgacaaaa gcattttatt ctcacttcat acgggtgctg ccgttcgcta
    12721 tgtttacaga cgggctttcc ttcaaatgaa tcatcttcgt ttttatcccg gcatcctcta
    12781 cgaggaccaa gaatttcttc ctcgcgtatt cagtttagcc aatagctttt acatttcttc
    12841 attcatttcc tatcgctatc ttttgcgctc atcaggctct atcatgtcgc agttctcgtt
    12901 gcgctcatta cgtgatacgc tcaccattgt gcgtagctat gagacatggc tgcaggaaga
    12961 gataaaagga aaatcagcct tgataaatgc ttatatcaat gggtgcatct ttaatcatac
    13021 ttactggttg ttgtcgttta aggctgttac ctttcgggac gaacagaaag aatttatgcg
    13081 cgaccattat gttgaaatac ggaggaagtg tctgacagca gggtggaagt cgctaaaagg
    13141 aaatttcaga ctgacgcgtg cggtccgcct cctgatggta ttcctcattc cacatcacct
    13201 cataaaatag ataaacttaa attattaatt atacattcaa gtaaatgaaa agatttttat
    13261 tacttcttct cttggcgttt gccatgtggg aactgcaagc gcaaattccc tactttgcca
    13321 gtacggccgg tgatgggaaa ctctatggat acacttcact gaaactacgt cctggtatca
    13381 atacacaaga gacttatacc acattccaat acggcattgg aaattccgta gctttgggta
    13441 cggatatcta tacaggagta ggttcaaatt atatgggatt cctggcccgt tatggtgtgt
    13501 cactgagtaa atggttcaat gttggtgcac agtttactcc atcgtttaat ttaagccata
    13561 actttgagtt tggt
//
