LOCUS       gnlProkkaDDAJDNLD_40   13479 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DDAJDNLD_40.
ACCESSION   gnlProkkaDDAJDNLD_40
VERSION     gnlProkkaDDAJDNLD_40
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 03:22:18
            Original ID  :: gnl|Prokka|DDAJDNLD_40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 45133
            Orig. end    :: 58612
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13479
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11620]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11620
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13479
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13479
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(751..2004)
                     /locus_tag="ctg40_42"
                     /transl_table=11
                     /translation="MFENIRLSFRGIWAHKMRSFLTMLGIIIGIAAIIAIVSTIKGTNE
                     QIKQNLVGAGENTVEISLYQGEWEYEMEYNGIPEGVPLVADEVVEQLKEIPHVENVSRY
                     LSRQDYNGVYHLNTGLSGGYVKGVDAAYFDTCNYIMKEGRGFTQQDFDQYHKVAILDED
                     SADALFQGEEAVGETIEIQQEPYVVVGIVTKAKKFEPVINSIDDYYTYAQDSAGSVYVP
                     ATTWPIIYQYDEPQNVVLRVESTDDMTSAGKAGADLLNGYLSVSDTTIQYKAKDLMEQA
                     QQIQELSSSTNTMLIWIAGISLIVGGIGVMNIMLVSVTERTQEIGLKKAIGARKSRILG
                     QFLTEAAVLTSLGGLIGVLVGIILAQVISYVTTTPVAISVPAAVGAVAFSMVIGIVFGV
                     FPSYKAANLNPIDALRHE"
     CDS             complement(2018..3694)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 43.2; E-value:
                     4e-13)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_43"
                     /transl_table=11
                     /translation="MKIKKVIAVIAGIAVALSAAVGGVYGYKSYQDKKLVAEVQPVSSL
                     NWGYWGDTETSYGTVTNDSSQEIYLDDSRMIKEVYVEKGDEVQKGDPLLAYDTAELQIE
                     IERKKLDISTIENNIERQKYKYEMLKTQTPVKKDPPKLNEEQLAWYQHMDEENRLTETD
                     KNDGRIYNYLTATSIPYNVTTNAAGELVYPAGTAEEPYIYYVNQNAYAYGGFFNAIRPT
                     AEGGSGKHVRVIVCKKDADGKMVLDTDEATGRQTPVTDDTVSPNTVELNGSDFPADYDE
                     SRMWYLFSGKEYIPTSLADEYMQAYEDFMADWEVPKGYTSEELYQEAADIEEKLKTLDI
                     QRRQEQLALESMEKSATDGVVYAEVDGVVKTVGDPDEKPEQGQAFLVVTGDDGLYVKGT
                     ISELLLDDVPVGTVVSANSWESGMTFDATITEISDYPVSGNSWGEGNPNVSYYEYTAYI
                     EDSSALRNGEAVDLSISTNQSDGGGIFIEKAYVRSEDGKSYCMIADENNRLKKQYVVTG
                     RTVYGSAVEIKSGLTEDDRIAFPYGKNAVEGAAVTDESSNY"
     CDS             complement(3691..4380)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 222.1; E-value:
                     1.3e-67)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_44"
                     /transl_table=11
                     /translation="MILNLQNIYKDYQQEKLVVPVLKDVSLTVEEGEYVAIMGPSGSGK
                     TTLMNIIGCLDRPTSGTYELAGENVLKLKDRELSDLRLKSIGFVFQSFQLMSRESAVEN
                     VALPLSYAGVRKKERRSRATKALERVGLGDRVNFRPTQLSGGQKQRVAIARAMVNHPKI
                     LLADEPTGALDSKSGEQIMELFDSLNEEGVTIVMITHDPKIAAKAKRIVRIIDGEIYEG
                     EEDGAVS"
     CDS             complement(4377..5750)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 77.6; E-value:
                     1.4e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_45"
                     /transl_table=11
                     /translation="MGKKSVGILIGVAAVAAVLGGTGYYFRDDIRQMIPIFDDGSSEDK
                     VYVEKVSRIMNQYAGVSNRYNGVVETQDSYEVNVDSSRTISEIKVEVGDEVEEGQTLVT
                     YDTSDLTMKIEQAKLELEGIQNEIDNYNKQIDTLTKEMEKVDESERYDYTTQIQNIQNS
                     IAQKQFDMESKKLEISKEQKQVSSSSVVSKVAGVVKEINEKGVDSNGNSAPFMTILQTG
                     EYRIKGSIDEQNVWMLSEGQEVVIRSRVDSTKTWSGTIGKIDTESPQQGNDNGYYSTSS
                     AGDTQSASKYPFYVDLDSVDGLILGQHVYIELDQGQEEVKEGLWLYGSYIVQDEDTPYV
                     WAANEKNRLEKHYIELGEYDADMDEYEIVSGLAEDDYIAWPMAGLYEGVTTVTDEAEVD
                     YSSPLYNQPADGNLYDTEGVYDTELLYDVLDSVYDTELPDEMYDSMDAGEGTEAEVAE"
     CDS             complement(5929..7167)
                     /NRPS_PKS="Domain: Aminotran_1_2 (76-364). E-value:
                     2.4e-14. Score: 45.1. Matches aSDomain:
                     nrpspksdomains_ctg40_46_Aminotran_1_2.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_46"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.3e-14, bitscore:
                     45.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTMEDIEAVDMEIAQAIKDEFDRQNSHIELIASENWVSPAVMSA
                     MGSVLTNKYAEGYPGKRYYGGCDCVDVVEELARERAKKLFGCDYVNVQPHSGAQANMAV
                     QFAVLKPGDTVMGMNLDHGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVMEIALE
                     CKPKMIIAGASAYARTIDFKKFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYADVV
                     TTTTHKTLRGPRGGMILCNQEAADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPE
                     FKVYQQNIIDNAQALCKGLMNRGIRIVSGGTDNHLMLVDLTNFDQTGKAVEKLLDSVNI
                     TCNKNTIPNDPKSPFVTSGVRLGTPAVTSRGFNTGDMDQIAEAIAMMIKEGEPAADRAR
                     AIVAELTAKYPLK"
     aSDomain        complement(6076..6939)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg40_46_Aminotran_1_2.1"
                     /evalue="2.40E-14"
                     /label="ctg40_46_Aminotran_1_2.1"
                     /locus_tag="ctg40_46"
                     /protein_end="364"
                     /protein_start="76"
                     /score="45.1"
                     /tool="antismash"
                     /translation="ARERAKKLFGCDYVNVQPHSGAQANMAVQFAVLKPGDTVMGMNLD
                     HGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVMEIALECKPKMIIAGASAYARTI
                     DFKKFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYADVVTTTTHKTLRGPRGGMIL
                     CNQEAADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPEFKVYQQNIIDNAQALCK
                     GLMNRGIRIVSGGTDNHLMLVDLTNFDQTGKAVEKLLDSVNITCNKNTIPNDPKSPFVT
                     SGVRLGT"
     CDS             complement(7305..7586)
                     /locus_tag="ctg40_47"
                     /transl_table=11
                     /translation="MDGMKLFAIYLAVMNVLGVAVMWSDKRRARLHRWRIPEKVLFGVS
                     LLGGSAGTWAGMYLFRHKTKHWYFVVGMPLILVCQAALAIYLVHLYVL"
     CDS             complement(7852..10014)
                     /locus_tag="ctg40_48"
                     /transl_table=11
                     /translation="MKKSKAIVILIVILGALAGLAYYASIILSSTGIGEEMSIPLGLDL
                     SGGVSITYQVVDDNPSAEDMSDTIYKLQKRVEGYSTEASVYQVGDDRITVEIPGVSDAN
                     AILEDLGNPGSLEFQLPDGTVYMTGDQVADAQAGTTTDSYGNKQYVVQLKLTDDGAKLF
                     ADATTDNVGNYLPIVYDGETISYPQVKEAITGGTAQISGMKTYEDAETLATQIRIGSLS
                     LKLQELESSVVGAQLGSQAISSSLKAAAIGLVIVMIFMIVMYQIPGLAAAIALAIYTCL
                     VIATLYLFEITLTLPGIAGIILSIGMAVDANVIIFARIREEIATGKTVNSSMKIGFKKA
                     MSAILDGNITTIIAALVLIALGSGTVKGFAYTLMIGIVLSMFTALVVTRWILYSFYAIG
                     IRDEKFYGRAKERRTLNFLGKRGVFFAVSLAMIAAGFIGMGVHAAKGSGALNYGLDFVG
                     GTSTTADYGKDYTIEEIENTIVPVVADVIGDNDIMANKVEGTTQITVKTRTLTLDERDT
                     LEQALVDQLGADESSITSQSISSTVSNEMRSDAIVAVIVASICMLIYIWFRFKDIRFGA
                     SAIIALLHDVLVVLAVYSLLRISVGNTFIACMLTIIGYSVNDTIVIFDRIRENLGRTAA
                     KQTPELLAEVANKSLTQTLSRSINTSLTTFIMVFMLFLLGVASIREFALPLMAGLLCGA
                     YSSICIATELWYIMRLHLGRNRLIKK"
     CDS             complement(10001..11371)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Quinohemoprotein_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_49"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.3e-35,
                     bitscore: 112.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Quinohemoprotein_rSAM_RRE (E-value:
                     2.1e-09, bitscore: 29.2, seeds: 15, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.2e-16, bitscore: 50.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.2e-13, bitscore: 41.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.2e-18, bitscore:
                     58.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYKNNGYDIVLDVNSGAIHVVDDVTYDVIALYEGHTREEIVN
                     SLRERYPETEVEEALDEVQMLVDNEELFTKDTYENYIMDFKKRPTVVKALCLHIAHDCN
                     LACQYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGNRRNLEVDFFGGEPLMNWQVVK
                     DLVAYGREQEKLHDKKFRFTLTTNGVLLNDEVMEFCNREMGNVVLSIDGRKEVHDKMRP
                     FRKGAGSYDLIVPKFQQFAESRHQDKYYVRGTFTHYNLDFSEDVLHLADLGFKQISVEP
                     VVAEPKEPYAIREEDLPKLFEEYDKLAVEMIRRHKSGEDFNFFHFMIDLEGGPCVAKRL
                     SGCGSGTEYLAVTPWGDFYPCHQFVGNEKFLLGNVDEGILNTDIRDEFKCCNVYAKEKC
                     RKCFARFYCSGGCAANAYNFSGDICGAYDIGCELQKKRIECAIMIKAAEEEQKNEEE"
     CDS             complement(11480..11620)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_50"
                     /sec_met_domain="TIGR03973 (E-value: 1.2e-27, bitscore:
                     87.4, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 8.9e-28, bitscore: 87.8,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHVKTLNTRKLQNTIKKGGCGECQTSCQSACKTSCTVGNQSCEN
                     R"
     CDS             complement(11737..12129)
                     /locus_tag="ctg40_51"
                     /transl_table=11
                     /translation="MKLGYKIKPRDTKSNPTTAILAAVFVMFLISGLLLLLLALLLYRM
                     EPGESVIKIGIVAVYVISGLCGGFLMGKRMREQKFLWGLAAGVIYFLLLFGVSPLVKGT
                     GDLQMTRIFSTLILCGASGMAGGMLS"
     CDS             complement(12183..13061)
                     /locus_tag="ctg40_52"
                     /transl_table=11
                     /translation="MRYILENDTLRVEIESFGAEIKSVKRKADGREYMWCGDPKYWGRT
                     SPVLFPFVGAPKNKEYRYEGRTYSMGQHGFARDMEFTLEAQEGKSIWFVLSSTEETYAK
                     YPFRFRLHIGYTLDENEVSVHWKVDNTDEKPMYFSIGAHPAFLCPINGEQDKTGYRLRF
                     GNLTERLHHHGNTPDGMAVMTDEELELEDGEAVITPGFFDKCTYMVEGAQTGEVSILDR
                     DGEAYVTVRFDAPLFALWSPEGKEAPFLCIEPWYGRCDAVDFEGSLAERPYENALAAGG
                     SFDAEYAIVFA"
     CDS             complement(13083..13478)
                     /locus_tag="ctg40_53"
                     /transl_table=11
                     /translation="MLQTEHERYLTEEIYKRPVFVTDYPKEIKAFYMKMNEDGKTVAAV
                     DCLVPGIGEIIGGSQREDDYDKLLARINELGLREEDYEFYLDLRKYGSARHAGFGLGFE
                     RCVMYLTGMSNIRDVIPFPRTVNNCEL"
ORIGIN
        1 gtgcaggccg gatgttccaa cagatcgtct atgatccccc ggtaaaatgc cgcatactcc
       61 tcattgatcc agttgatata gggttcaaaa aaggaaagtt ttgtgtaatt tccggtcagg
      121 atcacgtcat agcagggcgc cgcctgctct gcgtcaccct gtgcccccgc ttcttccgtc
      181 tcaactgcgg tgccctgtgc ccccgcttct tccgtctcaa ctgcggtgcc ctgtgccccc
      241 gcttttcccg tcttagcttc gtcttctccc tcccgcaatc cggttcccgc aagcggcaga
      301 aagccacgcg acacatactc cggataaaac tcttcaaaat atgccttctg tctccggtcg
      361 atgctgatat gccggtattt ttccggcaga tcttttaacc tgtcatcata aaagtacgga
      421 tggtcggcgg caatattata acagggaata tgataggtat cccagagata accgatcccc
      481 tcgcggtaca cgccggcctc cttttccaat ccctggaaat tgaaggtcac aagcaccgtc
      541 tctcgcggtc tgataaactt gcgcagcttt cccgcgctgc tctcctcctg tttcagatca
      601 tagaaaaata ctgcatatcc cagtttttga aactcccctg ccatctgatg ggagaaatag
      661 gataatgtct ccactccgcc ctccatcatg acaattcttt ttatcatgcc agctcctttc
      721 tgtccgcagc gctgtcatta ttttttttgc ttactcatgc cgcagcgcat cgatcgggtt
      781 taaattcgcc gccttgtagg acgggaacac accgaataca attccgatga ccatagaaaa
      841 cgccaccgct cccacggctg ccggaacgct gatcgccacc ggcgtcgtcg tcacatacga
      901 gatcacctgc gcgagaataa ttccgaccag cacgccgatg agaccgccca gactggtgag
      961 caccgccgcc tccgtcagaa actgtccaag aatccgggac ttgcgcgccc cgatcgcctt
     1021 tttcagaccg atctcttgcg tccgctccgt caccgatacc agcatgatgt tcatgacgcc
     1081 gataccgccg acaatcaacg aaatgccggc aatccagatc aacatggtgt tggtggaact
     1141 gctgagttcc tgaatctgct gcgcctgctc catcaggtct tttgccttat actggatcgt
     1201 cgtgtccgaa accgacagat acccgtttag cagatccgct cctgcttttc cggcgctggt
     1261 catatcatcc gtactctcca cgcgcagcac cacattctgt ggctcgtcat actgatagat
     1321 gatcggccag gtcgtcgccg gcacatacac agagccggcg gaatcctgcg cgtaggtata
     1381 atagtcatca atcgagttga tgaccggttc aaactttttc gcctttgtca caattcccac
     1441 cacaacatac ggctcctgct gaatctcaat cgtctccccg acagcttcct ctccctggaa
     1501 cagtgcgtcc gccgaatcct catccagaat cgccaccttg tgatactggt caaaatcctg
     1561 ctgcgtgaac ccgcgccctt ccttcataat ataattgcag gtgtcaaaat aagccgcgtc
     1621 aacgcccttg acataaccgc cggaaagccc ggtgttcaga tgatagactc cgttgtaatc
     1681 ctgccggctc agatagcgcg acacattttc cacatgcggg atctccttga gctgttcaac
     1741 cacctcatcc gccacaagcg gcacgccctc aggtatgccg ttgtactcca tctcatattc
     1801 ccactctccc tgatacaggg aaatctcgac ggtattctca ccggctccga ccaggttctg
     1861 cttgatctgc tcatttgttc ccttaattgt agatacaatc gcaataatag ctgcaatacc
     1921 gataataatt cccagcatcg tcaggaagga acgcatcttg tgagcccaga ttccgcggaa
     1981 agacaatctt atattttcaa acatctccgt tcctccttta ataattggat gactcgtccg
     2041 tgacggcagc gccctccacc gcatttttcc cgtacgggaa tgcgatgcgg tcgtcctccg
     2101 tcagcccgga cttgatctct accgcagatc cgtagaccgt tcttccggtc accacatact
     2161 gttttttcag ccggttattc tcatctgcaa tcatgcagta cgactttcca tcctccgacc
     2221 tcacatacgc tttttctata aaaatgccgc cgccatccga ctgattggtc gatatggaca
     2281 gatctaccgc ctccccgttg cggagcgcgg agctgtcctc gatataagcc gtgtactcat
     2341 agtaggagac attgggattt ccttcgcccc acgagttgcc cgaaaccgga taatccgata
     2401 tttccgtgat tgtggcatcg aacgtcatac cgctctccca ggaattggca ctcaccacgg
     2461 ttcccaccgg cacatcatcc agcagcagct cgctgatcgt ccccttcaca tagagcccgt
     2521 catctccggt taccaccaga aacgcctgcc cctgctcggg cttctcgtcc gggtcgccga
     2581 ccgtcttcac gacgccgtcc acctccgcgt agaccacacc gtccgtcgcg cttttctcca
     2641 tggactcgag cgccagctgt tcctgtctgc gctggatatc gagcgtcttt aatttttctt
     2701 caatgtcagc cgcctcctga tagagttcct cggaagtata tccctttggt acctcccagt
     2761 ccgccataaa atcctcgtac gcctgcatgt actcatccgc aagggaagtc ggtatgtatt
     2821 cttttcccga aaacagatac cacatgcggc tctcatcgta atccgccgga aaatcgctgc
     2881 cgtttaactc gacggtattc ggggacactg tatcatccgt aaccggcgtc tgccgcccgg
     2941 tcgcttcatc ggtgtcaagc accatcttac cgtccgcatc cttcttgcag acgatcacgc
     3001 gcacatgttt tccgctgccc ccctccgcgg taggacggat ggcattgaaa aagccgccat
     3061 aggcgtatgc attctgattg acataataaa tatacggttc ttccgccgtt cccgccggat
     3121 acaccagttc ccccgccgca ttggtcgtca cattgtaggg aatggaggtt gctgtcagat
     3181 agttgtagat tctgccatcg ttcttatccg tctctgtcag gcggttttcc tcgtccatgt
     3241 gctgatacca ggcaagctgc tcctcgttca gcttcggcgg atctttcttc accggcgtct
     3301 gcgtctttaa catctcatac ttgtattttt gtctctcgat gttattctcg atcgtgctga
     3361 tatcaagttt tttgcgttca atctctatct ggagttccgc tgtgtcatag gcgagcagcg
     3421 gatctccctt ttgcacttca tcccccttct ccacatagac ctccttaatc atcctggaat
     3481 catccagata gatctcctgt gaggaatcgt tcgtgacggt gccataactt gtctccgtgt
     3541 ctccccagta tccccagttg aggctggaaa ccggctgcac ttccgcgaca agctttttat
     3601 cctgatagga cttatacccg tatacgccgc ccaccgcagc cgagagggcg accgcaatac
     3661 ctgcgatgac cgcaatcact ttcttaatct tcatgatact gctccgtcct cctccccctc
     3721 atagatctca ccgtcgatga tccggacaat ccgcttggct ttcgccgcga tcttgggatc
     3781 atgcgtaatc atgacaatag taacgccctc ttcgttcaag ctgtcaaaaa gctccatgat
     3841 ctgctcgccg gatttggagt ccagggctcc tgtcggctca tccgccagca gaatcttagg
     3901 atggttgacc atcgcgcggg cgatggcgac acgctgtttc tgtccgccgg aaagctgtgt
     3961 cggtctgaaa ttgacacgat ccccgagtcc tactctctct agcgctttcg tcgcgcggct
     4021 ccgtctctcc tttttgcgca ctccggcata gctgagcgga agcgccacat tttccacggc
     4081 actctcccgc gacatcagct gaaagctctg gaacacgaac ccgatacttt ttaagcggag
     4141 atccgagagc tccctgtctt ttaatttgag cacgttctcc cctgccagct cgtaagtacc
     4201 gctcgtcggg cggtcgagac acccgataat attcatcagt gtggtcttac cggaaccgga
     4261 cggtcccata atggcgacat actctccttc ctcgaccgtc agcgatacat cctttaacac
     4321 cggcacaacc agcttctcct gctgatagtc tttgtagata ttctgcagat tcagtatcat
     4381 tctgccacct ccgcctctgt cccttctccg gcatccatgc tgtcatacat ttcatccggc
     4441 agttctgtat catagacgct gtccaacaca tcatagagca gttccgtatc atagacaccc
     4501 tctgtatcgt acagattccc gtccgccggc tgattgtaaa gcggagaaga ataatccact
     4561 tccgcctcgt cggtcacagt cgtcacaccc tcatagagac cagccatcgg ccaggcaatg
     4621 taatcgtcct ctgcaagccc tgatacgatc tcatactcgt ccatatccgc atcgtactct
     4681 cccagctcaa tatagtgctt ctccagacgg tttttctcat tagccgccca cacgtacgga
     4741 gtatcttcgt cctgcacgat ataggagccg tacagccaca gaccttcctt cacttcctcc
     4801 tgtccctgat ccagctcgat gtacacatgc tgccccagga tcagtccgtc caccgagtcg
     4861 agatccacat agaacggata cttggacgct gactgcgtat ctcccgccga agaggtgctg
     4921 taataaccgt tgtcattccc ctgctgcgga ctctcagtgt cgattttccc gatcgttccg
     4981 ctccacgtct tcgtactgtc cacacgcgaa cggatcacaa cctcctgccc ctcggaaagc
     5041 atccagacat tctgctcatc gatgcttccc ttgatccggt actctccggt ctgtaagatc
     5101 gtcataaacg gcgcgctgtt cccgttgctg tccacgcctt tctcattgat ctccttgacc
     5161 actcccgcca ccttgctcac aacggaagaa ctgctgacct gtttctgctc cttggagatc
     5221 tcaagcttct tgctctccat atcgaactgc ttctgtgcga tggagttctg gatattctga
     5281 atctgcgtgg tgtaatcgta gcgttccgat tcgtccacct tctccatctc tttcgtcagt
     5341 gtgtcgatct gtttgttgta attatctatc tcattctgga tgccttccag ctccagcttc
     5401 gcctgctcaa tcttcatggt aaggtcactg gtgtcgtaag tgaccagagt ctgtccctcc
     5461 tcgacctcat cgccgacctc caccttgatc tcgctgatcg tccgggaaga atccacattc
     5521 acctcgtatg aatcctgcgt ctccaccaca ccgttatacc ggttggaaac acctgcatac
     5581 tgattcataa tgcgggatac cttttccaca tagaccttgt cctctgaact tccatcatca
     5641 aagatcggta tcatctgcct gatatcatcc cggaaataat aaccggttcc tcccagaaca
     5701 gcagccactg ctgccacacc gatcagaatt ccaacgctct ttttgcccat agctcctcct
     5761 ctgccccaga cgggttgctt tcttttcctt attctatcat cttttcagac ccgatacata
     5821 gcgtttaatt cttaataatt tttgtagagt agaacattaa aaaagcctcc gcgcatattg
     5881 aacactcaca atatgcacgg aagcctagtc tacacacttt gaaagatttt attttaacgg
     5941 atactttgcg gtgagctccg ccacaatcgc tctggcgcga tctgccgccg gctctccctc
     6001 cttgatcatc atggcaatcg cctccgcaat ctgatccata tccccggtat tgaatccgcg
     6061 ggatgtcacc gccggcgtac cgagacgcac accactcgtc acgaacggag acttcggatc
     6121 gttcggaatc gtatttttat tgcaggtgat atttacggaa tccagaagct tttccaccgc
     6181 ttttccggtc tgatcaaaat tcgtcaggtc gacaagcatc aggtgattgt cggtgcctcc
     6241 cgatacgatc ctgataccgc ggttcatcag tcctttgcac agcgcctgcg cattgtcgat
     6301 gatgttctgc tggtacacct tgaactccgg ctgcagtgct tccttgaagc agactgcctt
     6361 cgccgcgatc acatgcatca gcggacctcc ctggattcct gggaagattg ccttgttaaa
     6421 gttgtacttg tctgccgctt cctgattgca gagaatcatt ccgccgcgcg gtccgcgcag
     6481 agtcttgtgc gtggtcgttg tcacgacatc cgcatacggg atcgggcttg gatgaagtcc
     6541 cgccgcaacc agaccggcaa tgtgcgccat gtcaaccatg agcacggcac cgcaggcgtc
     6601 cgcgatctca cggaatttct taaagtcgat cgtgcgcgcg taggcactgg cacctgcaat
     6661 aatcatcttc ggcttgcact cgagggcaat ctccatcacc ttgtcgtaat cgatgaatcc
     6721 ctcgtcgttc acaccgtacg gtacgatatg aaaataggtt ccggaaaaat tgaccggtga
     6781 accgtgcgta agatgtccgc cgtgatccag attcataccc atcacggtgt cgcccggctt
     6841 taaaacagcg aactgcactg ccatattcgc ctgtgctccg gaatgtggct gcacgttgac
     6901 atagtcacag ccgaacagct tcttcgcgcg ctctcttgcc agctcctcca cgacatccac
     6961 acagtcgcat ccgccgtaat agcgcttccc cggatagcct tccgcatatt tattagtcaa
     7021 aacgcttccc atcgcagaca tcaccgccgg gcttacccag ttctccgatg cgatcagctc
     7081 gatatgactg ttctgtctgt caaactcatc ctttattgcc tgtgcgattt ccatatctac
     7141 cgcttcgata tcttccattg tatacatcgt atgtattctc ccttcctgaa ccgccgcact
     7201 gtctttctac gaaaaacatt tgtctttcta cggctatgct actcattata aatgactttg
     7261 tatctttatt caatcagaaa acacataccg tctataacaa tttgttataa aacatataag
     7321 tgcaccagat aaattgcaag tgccgcctgg caaaccagaa tgagcggcat tccgaccaca
     7381 aaataccagt gcttcgtctt gtggcggaac aaatacattc ctgcccaggt tcccgcgctt
     7441 cccccgagca ggctcacacc aaagagcacc ttctccggaa tccgccaccg gtgcagtctt
     7501 gcgcgcctct tatccgacca catgaccgcc acaccgagca cattcataac cgccaaatag
     7561 attgcaaaca acttcatccc atccatctca tttctcctca atgaccgttt ccatgtcact
     7621 ccacaaactg gacatccaga tctaccgctc cctcaattcc atccactctt ccctcttcac
     7681 tgtactgcca gaaggtaaat atggcagggt caatctctgc gccataccat tatacacgct
     7741 atcgtacgtt tcttcatgcc tgcttcccgt tattttcctt tttcctgcag ggaaataaaa
     7801 agggctgcaa atacatcttt ggtcaatgta ttgcagcctc taatatttgt tttatttctt
     7861 gatcagtctg tttctgccaa gatgcagtct catgatgtac cacagctccg ttgcaataca
     7921 gatggaagaa tatgctccgc agagcagacc tgccatcaac ggaagtgcaa actcacggat
     7981 acttgcaaca ccgagtaaga acagcatgaa taccatgata aaggttgtca gagacgtatt
     8041 gatacttcgt gaaagcgtct gtgtcaaact cttgttggca acctccgcca gaagctccgg
     8101 cgtctgcttt gcagctgtcc tgcccaggtt ctcacggata cggtcaaaga taacgatcgt
     8161 atcattgaca gagtaaccga tgatcgtcag catacatgcg ataaaggtat ttccgacgga
     8221 aatacgaagc agtgaataaa ccgcaagcac taccagcaca tcgtgcagca gcgcaatgat
     8281 cgcacttgca ccgaaacgga tatccttgaa ccggaaccag atgtagatca gcatgcagat
     8341 cgaagctacg atcacggcaa cgatggcatc ggaacgcatc tcattgctga cagtggagct
     8401 gatactctgt gatgtgatgg aagattcatc cgctccaagc tgatccacca gtgcctgctc
     8461 cagcgtatct ctctcatcca gcgtcagggt acgcgtcttt accgtaatct gtgtcgtacc
     8521 ttccactttg ttcgccatga tgtcattgtc gccgatcaca tctgcaacca ccggaacgat
     8581 ggtattctca atctcttcaa tcgtgtaatc cttaccataa tctgcagtgg tggaagtacc
     8641 tcccacaaaa tccagaccat agttcaacgc tccgcttccc ttggccgcat gaacgcccat
     8701 tccgataaat cccgctgcaa tcattgccag agaaaccgca aagaatacgc ctctctttcc
     8761 aaggaagttc agcgtcctgc gctcttttgc acggccatag aacttctcgt cacggatacc
     8821 gatggcatag aaggaataca ggatccatct tgtcacgaca agcgctgtga acatggaaag
     8881 tacaatacca atcatcagag tgtatgcaaa acccttaact gtaccggaac ccagcgcaat
     8941 cagtaccagc gccgcgatga tcgttgtgat gttaccgtca aggatggctg acattgcctt
     9001 cttaaaaccg atcttcattg aagaattgac cgtcttgccc gtcgcaatct cctcacggat
     9061 acgcgcgaag ataatgacat tcgcatcgac cgccataccg atacttaaga tgatacccgc
     9121 aatacccggc agtgtcagtg taatctcaaa taagtataat gtagcaatta ccagacaggt
     9181 atagattgcc agcgcgatgg ctgccgccag acccggaatc tgatacatca caatcatgaa
     9241 gatcatgacg atcactaaac cgatggctgc tgcctttaag ctggaagaga ttgcctggct
     9301 tcccagctgt gctcctacaa cgctggattc cagctcctgc agctttaagg aaagagaacc
     9361 gatacggatc tgtgttgcca gtgtctcggc atcctcatat gtcttcatgc cggaaatctg
     9421 tgcggtaccg ccggtgatgg cttcctttac ctgcggatag ctgatcgtct cgccgtcata
     9481 cacgatcggc agataattgc cgacattgtc tgtggtggca tccgcaaaca gctttgctcc
     9541 gtcgtctgtg agctttaact gtaccacata ctgcttgttg ccgtagctgt ctgtggtggt
     9601 tcccgcctgc gcatccgcaa cctggtcacc cgtcatgtaa accgttccgt ccggaagctg
     9661 gaactccagg gaacccggat taccgagatc ctccagaatc gcattggcat ccgatacgcc
     9721 cgggatctca accgtaatac ggtcgtctcc cacctggtaa accgacgctt ctgtgctgta
     9781 gccctctaca cgcttctgca gcttgtagat cgtatcgctc atatcctccg cactcggatt
     9841 gtcatccaca acctgatagg taatggagac accgccggat agatccagac caagcggaat
     9901 actcatctct tccccgattc ccgtcgaaga aagaatgatg gatgcataat aagcaagtcc
     9961 cgccagtgcg ccaaggatca cgatcaaaat aacaatcgct ttactcttct tcattctttt
    10021 gttcctcctc tgcagctttt atcataatcg cacattcgat gcgctttttc tgaagctcac
    10081 atccgatgtc atatgctccg cagatgtcgc cgctgaaatt gtaggcattc gccgcgcagc
    10141 cgccgctgca gtagaatctt gcgaaacact tgcggcattt ctccttcgca tagacattgc
    10201 agcatttaaa ctcgtcgcga atgtctgtat ttaagatgcc ctcatcgaca tttccgagaa
    10261 ggaacttttc atttccgaca aactgatggc acggatagaa atcgccccac ggggtgaccg
    10321 ccagatactc ggttcccgaa ccgcagccgg aaagacgctt cgccacacac ggaccgccct
    10381 caagatcgat cataaagtgg aagaaattaa aatcttctcc gctcttatga cgtctgatca
    10441 tctcaactgc cagcttgtca tactcctcga agagcttcgg cagatcctcc tcccggattg
    10501 cgtacggctc cttcggctcc gccacaaccg gctccaccga aatctgcttg aatccgagat
    10561 ctgcaagatg cagcacatcc tccgagaaat caagattata atgtgtaaag gttcctctca
    10621 cataatactt atcctgatgt ctgctctccg cgaactgctg gaacttcggc acgatcagat
    10681 cgtagcttcc cgcacccttg cggaacggcc gcatcttatc gtgaacttcc ttccgtccgt
    10741 caatacttaa aacgacattg cccatctcgc ggttacagaa ttccataacc tcatcattta
    10801 aaagcacacc gtttgttgtg agcgtaaagc gaaacttctt gtcgtgaagc ttctcctgct
    10861 ctctgccgta tgccacaaga tccttgacca cctgccagtt cataagcggt tccccgccga
    10921 aaaaatccac ctccaggttg cgtctgttgc cggaattggc aatcagaaaa tcaagtgcct
    10981 tcttcccgac ttcaaaggac ataagagccc ttctcccgtg gtactcgccc tcctcggcaa
    11041 agcaatactg acaggcaagg ttgcagtcat gcgcaatgtg caggcacaga gccttcacaa
    11101 ccgtcgggcg ctttttgaaa tccatgatat agttctcgta ggtatccttc gtaaaaagct
    11161 cctcattgtc gaccagcatc tgcacctcat caagtgcctc ttccacttca gtctccggat
    11221 agcgctcccg cagagaattc acaatctcct ctcttgtatg tccttcatac agggcaatga
    11281 catcgtatgt cacgtcatcc accacatgaa tcgcgccgct gtttacatcc agaacaatat
    11341 catagccgtt gttcttatac tgatgaacca ctataatatt tcctctcttt ctaattctga
    11401 ctattataac gtacaaatga ccgcacgctt cgcgaacggt cgtctgtagg taatgctatg
    11461 cacttatgcc cgtgaaaaat tatctgttct cacagctctg gtttcctacg gtgcaggatg
    11521 tcttacatgc agactgacat gatgtctggc actcgccgca tccgcccttc ttgatggtgt
    11581 tctgtaactt tctggtattt aatgtcttaa cgtgcttcat aataatctct cctttatatc
    11641 ttacaataaa attctattaa cccgtatagt atagcacatg accggttaga tgaaaagcct
    11701 ttttttgctg aactttcgcc ccacagagcg gctttttcag cttaacattc ctcccgccat
    11761 gccggatgca ccgcagagga tcagcgtcga aaaaatgcgc gtcatctgaa gatcacccgt
    11821 accctttacg agcggcgaca caccaaacag cagcaggaaa tagatgactc ccgccgccag
    11881 tccccacaaa aacttctgtt cccgcatccg ttttcccatc agaaaacctc cgcaaagccc
    11941 ggaaatcaca tagaccgcca caattccgat cttaatgacg gactctcccg gctccatcct
    12001 atataagaga agcgccagaa gaagcagcag aagaccgctt ataaggaaca tcacaaacac
    12061 ggcggcaagg atggctgtcg tcgggttgct ttttgtatct ctcggtttta ttttgtatcc
    12121 cagcttcata gatagacctg cctgattctt tctatcctat ctatatgccg gttcgcgtgc
    12181 ggctatgcaa acacgattgc gtactctgcg tcaaaactgc ctccggctgc aagcgcattc
    12241 tcatacgggc gctccgccag gcttccctca aagtcaaccg catcgcatct tccataccac
    12301 ggctcaatgc acaggaacgg cgcttccttt ccttccggag accacagagc aaacagcggc
    12361 gcatcaaagc gtaccgtcac ataggcctcg ccgtcacgat ccaggattga cacctctccc
    12421 gtctgcgctc cctccaccat gtaggtgcac ttgtcaaaga atccgggcgt aatcacagcc
    12481 tctccatcct ccagttccag ctcctcatcc gtcatgactg ccatgccgtc cggcgtgttg
    12541 ccgtgatgat gcagtctttc ggtaagattt ccgaaccgga gacgataccc cgtcttatcc
    12601 tgttccccgt tgatcgggca caaaaatgcc ggatgtgcgc cgatggaaaa atacatcggc
    12661 ttctcatcgg tgttgtccac cttccagtga acggagactt cattttcgtc cagcgtgtat
    12721 ccgatgtgca gccggaaccg gaacggatat tttgcatagg tctcctctgt ggaggagaga
    12781 acaaaccaga tgctctttcc ctcctgtgcc tccagagtaa actccatatc gcgcgcgaat
    12841 ccgtgctgtc ccattgaata tgttctgccc tcataccggt attccttgtt cttcggcgca
    12901 ccgacaaacg ggaagagcac cggcgatgtt ctgccccagt atttcggatc tccgcaccac
    12961 atatattccc tgccgtccgc cttgcgtttc acagacttga tctccgcgcc gaacgattcg
    13021 atctcgaccc gcagcgtgtc attttccaaa atatatctca tgcttcacct cagtcttccc
    13081 tcttacagtt cgcagttgtt gaccgttctc gggaacggaa tgacgtcacg gatgttggac
    13141 ataccggtca ggtacatcac gcagcgctcg aatccgagtc cgaatcctgc atgtcttgcg
    13201 gaaccatact ttctgagatc gaggtagaac tcataatcct cctcgcgaag tcccagctcg
    13261 ttgatacgcg ccagaagctt gtcgtagtcg tcctctctct ggcttccgcc gatgatctct
    13321 ccgattcccg gaaccagaca gtcgactgcc gctaccgtct tgccgtcctc gttcatcttc
    13381 atgtagaacg ccttgatctc cttcggataa tctgtcacaa ataccggacg cttgtaaatc
    13441 tcctctgtca gatagcgctc atgctccgtc tgaagatcc
//
