LOCUS       c00086_gnlPro..        15545 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNBHGGCD_86.
ACCESSION   c00086_gnlPro..
VERSION     c00086_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 03:18:22
            Original ID  :: gnl|Prokka|HNBHGGCD_86
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 22912
            Orig. end    :: 38457
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15545
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[32912:36354]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13442
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..15545
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15545
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(3..1973)
                     /locus_tag="ctg86_19"
                     /transl_table=11
                     /translation="MTTFVRFLNKKILQNPTNMIKYIGWFFNLMLQLIHFTQEREILYM
                     KMKREDVRNIAIIAHVDHGKTTLVDELLKQSGVFRANQEVQERVMDSNDIERERGITIL
                     SKNTAITYKGTKINVIDTPGHADFGGEVERVLKMVNGVILVVDAFEGVMPQTKFVLMKA
                     LELSLPVIVCLNKVDRPEARPNEVVDEVLELFMDLDASDEQLDCPFLFASARDGYAVRE
                     IGDLVNNKKDMTPLFETIIDYIPAPEGDPDANTQVLISTIDYNEYVGRIGIGKVDNGCL
                     KVNQEAVVVNHHEPDKQKKVRISKLYEFDGLNKVDVAEAKIGSIVAISGIADIHIGDTI
                     CAPENPVAIPFQKISEPTLSMNFMVNDSPLAGQEGKFITSRHLRDRLFKELNTDVSLRV
                     EETESPDCYKVSGRGELHLSVLVENMRREGYEFAVSKAEVLYHTDENGKKTEPMEIAYV
                     DVPDEFTGTVIDKLSQRKGELVNMKPITGGYTRLEFNIPSRGLIGYRGDFMTDTKGNGI
                     INTIFNGYAPYRGEIAYRKLGSLIAFESGESVTYGLFSAQDRGTLFIGPGEKVYAGMVI
                     GSCARAEDIELNVCKKKHLTNTRSSSADEALTLVPPKVLSLEQALDFIDVDELLEVTPE
                     SLRIRKRILDPTLRKRANMKK"
     CDS             2130..2765
                     /locus_tag="ctg86_20"
                     /transl_table=11
                     /translation="MADKMFENNQVSIVGEIVSDFRFSHEVYGEGFYMVDVAVNRLSNY
                     MDYIPLMISERLIDVNEDMVGQNIYVTGQFRSFNRHEEKKNRLVLSVFVRELEFLDEID
                     DEVKSNQIFLDGYVCKEPIYRKTPLGREIADLLIAVNRSYGKSDYIPCICWGRNARFAS
                     GFDVGGHVQIWGRIQSREYVKKLSETQTEKRVAYEVSVSKIDFLEELD"
     CDS             3160..4050
                     /locus_tag="ctg86_21"
                     /transl_table=11
                     /translation="MSIFKGAGVAIVTPMKNNEEVNYDRLEQMIEYQINQGTDCIIIAG
                     TTGESSTLTTEEHAEVIKAAVKFAKHRIPVVAGTGSNCTREAIHLSEEAEKAGVDGLLC
                     VTPYYNKATQGGLIRYYTEIANSVKLPIIMYNVPSRTGCNILPETAAKLYHDVENIVAI
                     KEATGNVAQAAKTMYLTDGKLDLYSGEDGIVVPLMSIGAIGVISVWSNVAPKDVHDMCM
                     AFFDGDTKKAMEIQLKAQPLIEALFSEVNPIPVKKALNLMGMEAGPLRSPLTEMTDANA
                     AKLAEAMKNYGIKLA"
     CDS             4155..4922
                     /locus_tag="ctg86_22"
                     /transl_table=11
                     /translation="MIRAIMSGCNGKMGQVITGICKEDAEIEIVAGIDLYDGIKNDYPV
                     FPNISVCDVAADVIIDFSNAKAVDDLLVYSVDKQIPVVLCTTGLSEEQLKKVDEASKKV
                     AVLKSANMSLGINMLMELLKQAATILAPAGFDMEIVEKHHNQKLDAPSGTALALADSMN
                     EALDNAYTYTYDRSKERKKREKTEIGISAVRGGSIVGEHEVIFAGLDEVIEFKHTAYSR
                     SVFAKGAVQAAKFLSGKPAGFYDMGDVIKATIA"
     CDS             5019..6983
                     /locus_tag="ctg86_23"
                     /transl_table=11
                     /translation="MGQTDLRYLKSLSNQYPTIATAATEIINLQAILSLPKATEHFITD
                     VHGEYDQFLHVLKNGSGAIKRKIEDEFGNAISAAEKKAIATLIYYPEQKLEQVLKTEDN
                     LEDWYKVTLYRLIRICKNASSKYTRSKVRKALPKDFAYVIEELLTGRQEISDQEAYYNE
                     IIRSVIRTGRAAELVIAFCNLIRRLVVDHLHVVGDIFDRGPYPNLIMDTLMEHHSVDIQ
                     WGNHDVYWMGAASGSAACICNVIRISAKYGNLDLLEDGYGINLVPLARFAMKWYDKDSC
                     DCFKLDYREDEYDVHDAFLDEKMHKAITIMQFKLEGQLIKEHPEFEMEKRLLLDKINIE
                     KGTVCVEETEYPLKDVSFPTIDWEDPYRLSEDEADVMERLVTAFVNCEKLQRHVRFLYT
                     QGSLYKVYNGNLLYHGCVPLNEDGTFTRVNVFGKEYAGKELYDVLEGYARKGYYAIDPK
                     EKKKGQDILWFIWENQNSPVFGKAKMTTFERYFIADKKTHQEPKNPYYRLLEKEEVVNR
                     ILEEFGLEGAEAHIINGHIPVEAKKGESPVKCNGKLLIIDGGFSKAYQPKTGIAGYTLI
                     YNSYGLVLAAHEPFESVEKAVQDGSDIVSHTVLVQQVVRRKTVADTDIGKSLKESIHDL
                     EELLAAYRAGTIVEKNRAE"
     CDS             7067..7894
                     /locus_tag="ctg86_24"
                     /transl_table=11
                     /translation="MLIGNHLSASKGYAAMGKAALALDANTFAFFTRNPRGGKAKEIDE
                     KDVEKFLNFAKEHEFGKIVAHAPYTMNLCAAKEDVRSFSKEMLLDDLKRMEYTPYNYYN
                     FHPGSHVGQGAEKGIALIAEALNEALKPEQTTTVLLETMAGKGTEVGRTFEELREILDR
                     VELNDKMGVCLDTCHVWDGGYDIVNDLDGVLNEFDRVIGLDRLKAVHFNDSMNDCGSHK
                     DRHAKIGEGKIGAEAMRRVALHPLLEGRPFILETPNDDEGYRREIQMVREWTR"
     CDS             8479..9933
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg86_25"
                     /sec_met_domain="OKR_DC_1_C (E-value: 3.1e-12, bitscore:
                     37.9, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.6e-130,
                     bitscore: 426.2, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKEQQMRAPVYEALEKLKKRRVVPFDVPGHKRGRGNPELVELLG
                     EKCVSLDVNSMKPLDNLCHPVSVIKEAEELAAEAFRAEHAFFMVGGTTSSVQGMVLSCC
                     KAGDKIILPRNVHKSVINALVLCGAIPVYVNPEVDVKLGISLGMQVSEVERAILENPDA
                     VAVLVNNPTYYGICSDLRSIVRVAHEHHMLVLVDEAHGTHLYFGENLPVCAMDAGADMA
                     SVSMHKSGGSLTQSSLLLTGKGVNWEYVSQIINLTQTTSASYLLMSSLDISRRNLALRG
                     KESFAKVAQMAEYARDEINSIGGFYAYGKDMVNGGSVYDFDVTKLSVYTRDIGLAGIEV
                     YDLLRDEYDIQIELGDIANILAYISIGDRIQDIERLVGALADIKRLYSKDPAKMLNTEY
                     INPKVLVSPQVAFYSQKESMPVRQTAGRICGEFVMCYPPGIPILAPGEMITPEIIEYIV
                     YAKEKGCSMQGTEDPEVENLNVLAKK"
     CDS             10001..10864
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_26"
                     /sec_met_domain="Spermine_synth (E-value: 8.2e-52,
                     bitscore: 166.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 6.6e-13,
                     bitscore: 39.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWFSDYHTEKVKVSVKVQKQLFGLQTEFQRIDVFDSDEFGRFL
                     SSDGSIVFSEKDEFVYDEMIVHVPMAVHPHVKKVLVIGGGDGGVARELGYYDEIEQIDV
                     VEPDRVFVEVCKEFFPDNACGLSDERVTVYYEDGLKFLRMKHDEYDLIINDAIDPLGHT
                     AGLFTKEFYGNCFRALKDDGIMVYQHGSPFYDEDEESCRGMHRKASHSFPISRVYQAHI
                     PTCSSGYWLFGFASKKYHPLDDLDAKRWKERKIKTWYYTTNLHKGAFMLPRYVEDMLEE
                     EEGRKK"
     CDS             10962..12221
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_27"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.6e-44, bitscore:
                     143.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 5.7e-35,
                     bitscore: 111.4, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Epimerase (E-value: 2.5e-07, bitscore:
                     21.3, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLLIIGCGGVAGVAIHKCCQNSKTFTEICIASRTKSKCDALKE
                     KLEKTTDTVITTAQVDADNTEELIALIKKYQPDAVLNVALPYQDLTIMDACLACKVDYI
                     DTANYEPEDTDDKEWRAIYEKRCKEEGFTAYFDYSWQWAYREKFKEAGITALLGSGFDP
                     GVTSVFTAYALKHYFDEIETIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWENGH
                     WVETKPMEIKREYNFPQVGEKDMYLLHHEEIESLAKNVPGVKRIRFFMTFGQSYLTHMK
                     CLENVGMLSTSPIEYEGREIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGKKDGKEK
                     TIYIYNVCDHQECYKEVGSQAISYTTGVPAMIGAALVVDKVWDKDGVFNIEEFDPDPFM
                     DMLNQYGLPWVVDENPQTVA"
     CDS             12309..13442
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_28"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 8.5e-14,
                     bitscore: 42.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWQEIPTPCYVVDEKKLKQNLKILQNLEQETGCHVLLAQKAFSM
                     FSLYPLIGQYISGTTASGIFEARLGKEEMGKENHVFAPAYKEKDMEELVQICDHVIFNS
                     FAQYEKYQHYFLQQECTASAGIRVNPECSTQEGHEIYDPCGPGSRLGVVKSEFPDQLPE
                     GIEGLHFHTLCEQNADDLITTWHAFEEKFGSYLKQVKWLNLGGGHHITRADYQLDELKK
                     LICEIRRKYNVRVYLEPGEAIALNAGYLVTEVMDIVHNGMDILILDASAACHMPDVLEM
                     PYRPPLKDGYLPGEKPHTCRLSSMTCLAGDVIGDYSFAQKKQVGDRLVFEDMAIYSMVK
                     NNTFNGMPLPGIAVLREDGDVEMIKEFGYEDFKGRLS"
     CDS             13414..14637
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg86_29"
                     /sec_met_domain="PAD_porph (E-value: 1.7e-117, bitscore:
                     383.2, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISKADCPEMIKDTTPVQDGFFMPGEFEQHQGCIMIWPERPGSW
                     RNGAKEAETAFSAVIRAIAASETVYVAAGKKGIDHAKAFAESLKKEENLHPVVVFEMET
                     DDSWARDVAPTFLVNRTDGKISDLTAAGNGTAQTGDDVKNSQVRGVNWSFNAWGGEVDG
                     LYASYEKDNAFAWNFCRKFEFDCYDAEPFVLEGGSIHSDGEGTLLVTESCLLSAGRNPS
                     LTKEQIEEQLKCYLGVEKVLWLPRGIYQDETNEHVDNVCAFLRPGEVVLAWTNNQNDPQ
                     YAMSKASFEYLSSVRDAKARKLIIHKLPIPDIPVCITKEELEGYEFEEGEDVREVGERL
                     AASYVNFYFSNNAVVMPVFGGENEESDLRAQQIMAKLCPDRKIIPVYARDILTGGGNIH
                     CITQQIPL"
     CDS             14793..15545
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg86_30"
                     /sec_met_domain="CN_hydrolase (E-value: 1.1e-47, bitscore:
                     153.5, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKAAAEGANIILLPELFEREYFCQQRRYDFYSYARTVEESEAV
                     AMGVRLAKELGVVLPISFYERDVNNLYNSIACIDGDGTILGVYRKTHIPDDHYYQEKFY
                     FTPGDTGFKVFDTKYGCIGIGICWDQWFPETARAMALLGAELLFYPTAIGSEPILECDS
                     MPHWRRCMQGHAAANLMPVIAANRIGREVVQPCAENGGQESALEFYGSSFLTDETGEVI
                     LSASRDKEEILSQTYELDELRAKRLEWGL"
ORIGIN
        1 gattattttt tcatattagc acgtttacgt aaggttgggt ctaagatacg cttacggata
       61 cgaaggcttt ccggtgttac ctccagaagt tcgtcgacat caataaagtc aagtgcctgc
      121 tctaagctta aaacttttgg cggaaccagt gtcagtgctt catcagcaga agaagaacgt
      181 gtattggtaa gatgtttttt cttacatacg tttaactcga tatcctcagc tcttgcacag
      241 gaaccgatga ccattccggc ataaactttt tcgccaggtc cgataaataa agtaccgcgg
      301 tcctgggcag agaacagacc ataagttacg gattcgccgg attcaaatgc gatcagggaa
      361 ccaagtttac ggtatgcgat ctcaccacgg taaggagcat agccgttgaa aatggtattg
      421 atgataccgt ttcctttggt gtctgtcatg aaatctccac ggtaaccgat gagaccacgg
      481 gatggaatat taaactccag acgggtgtaa ccgccggtga tcggtttcat attgacaagc
      541 tcacctttac gctggcttaa tttatcgata acagtaccgg taaactcatc cgggacatcg
      601 acgtaagcga tctccatagg ctctgtcttt ttaccgttct cgtctgtgtg gtataaaact
      661 tctgctttgc tgactgcaaa ctcataacct tcacggcgca tgttctcaac taaaacggat
      721 aagtgaagct caccacggcc ggatactttg tagcagtccg gactctctgt ctcttctaca
      781 cgcagagaaa catcggtatt taattctttg aacagacggt ctcttaaatg gcgggaagtg
      841 atgaatttac cttcctgtcc ggcgagcggg ctgtcgttta ccatgaagtt catggaaagc
      901 gtaggctcag aaatcttctg gaacggtatt gcaaccggat tttccggtgc acagatcgta
      961 tctccgatgt ggatatctgc gataccggag attgctacga tcgatccgat ctttgcttct
     1021 gcgacatcta ctttatttaa gccgtcaaat tcatataatt tgctgatgcg gacttttttc
     1081 tgtttgtccg gttcatgatg gtttaccaca acagcttcct gatttacttt taagcatccg
     1141 ttgtcgactt taccgatacc gatacgtccg acatactcgt tgtaatcgat ggtactgatg
     1201 agtacctgtg tgtttgcatc cggatcacct tctggagccg gaatgtaatc aatgatagtc
     1261 tcaaacagag gtgtcatatc ttttttgtta tttacaagat ctccgatctc gcgaacggca
     1321 tagccgtctc ttgcagatgc aaacaggaac ggacagtcta actgctcatc ggatgcgtct
     1381 aagtccatga ataactcaag tacttcatcg acaacctcgt tcgggcgggc ttccggacgg
     1441 tctactttat ttaaacatac gataaccgga agagaaagtt ctaatgcttt catcagtacg
     1501 aatttggtct gaggcataac accctcgaat gcgtcaacga caaggataac accgtttacc
     1561 attttaagga cacgctcaac ctcaccacca aagtccgcat gaccaggagt atcgatgaca
     1621 ttgatctttg tacctttata ggtaatggct gtgttttttg aaaggatcgt gataccacgt
     1681 tctctctcga tatcattgga gtccatgaca cgttcctgaa cttcctgatt cgcgcggaat
     1741 acgccgctct gctttagcag ctcatcgacc agagttgttt taccgtggtc aacgtgtgca
     1801 ataatggcaa tattacggac atcttcacgt ttcattttca tatacaaaat ctctctttcc
     1861 tgtgtgaaat gtattaactg taacataagg ttaaaaaacc aacctatata ttttatcata
     1921 tttgtgggat tctgcaatat ttttttattc aaaaacctga caaaagttgt cattacattc
     1981 gttttcttat cgacatgttc catgaaaatt tgaatgtgat acatggtaaa aatattatgt
     2041 caggcaggtc ataccgggca gaaacggttc gaaaagaaaa aacgcacaaa aaaatatagg
     2101 tgtatgaccg caaggaaggg agaatattca tggcagataa aatgtttgaa aacaaccagg
     2161 tgtcgatcgt gggggagatt gtatcggatt tccggttcag ccacgaagtg tacggagagg
     2221 gattttatat ggtcgacgtg gcagtcaacc gtctcagcaa ttatatggat tacataccat
     2281 tgatgatttc ggaacgattg atcgatgtca atgaggacat ggtcggacag aatatttatg
     2341 tgacaggaca gttccgctca ttcaaccggc acgaggaaaa gaaaaaccgg cttgtacttt
     2401 ccgtttttgt gagagaactg gaatttttag acgagattga cgatgaggta aagagcaacc
     2461 agatcttttt agacggctat gtatgtaagg agccaattta ccggaaaaca ccgcttggaa
     2521 gagagatcgc agatcttctg atcgctgtga accgctctta tggaaaatca gattacattc
     2581 cgtgcatctg ctggggacga aatgcaagat ttgcctccgg ttttgatgtg ggcggacatg
     2641 tgcagatctg gggcaggatc cagagccgcg aatatgtcaa aaaattatcg gagacgcaga
     2701 cggaaaaaag ggttgcatac gaagtatccg tcagcaaaat tgatttttta gaggaattgg
     2761 attgacagta gaaatagatg gtgctatgat tgctaaaaga tacatattgc ttgatagagg
     2821 ttgcgtgctt taagagtagt tttccggatg tggcagaagc agaggatgga ggataaaagg
     2881 aaagaacgcc gaaggagtat atttgctgcg gatatgttcc tgggcataag gtaaagaacc
     2941 ttatgactgt catcttaagc tgaaatggca gaaagatggg gcgctatcgg attcgacata
     3001 tactgggtaa tacatatgat tagaatttac gaaccggctc atcagagtcg gtttttttaa
     3061 ttcataggga aattacgtcc tatgaataaa taaaataccg tgtgcacaaa gcagtgtatc
     3121 ctaacgtatc ataatacagg aaccaggagg attattaata tgtctatttt taaaggagcc
     3181 ggtgtggcaa tcgtaacacc aatgaaaaac aatgaggaag taaattatga cagattagag
     3241 cagatgatcg agtatcagat caatcaggga acggactgta tcattatcgc aggtacaaca
     3301 ggtgagagct ctacgctgac gacagaagag catgcagagg tgatcaaagc tgctgttaaa
     3361 tttgcaaaac accgtattcc ggtcgttgca ggaaccggtt caaactgtac aagagaggca
     3421 atccaccttt cggaagaagc ggaaaaagcc ggcgtggatg gactgctctg cgtaactcca
     3481 tattataaca aagcaacaca gggaggtctg atccgctact acacagagat tgcaaattct
     3541 gtaaaacttc ctattatcat gtacaatgtt ccaagccgta ccggatgcaa tatccttccg
     3601 gagacagctg caaaactgta ccatgatgtt gaaaacatcg ttgcgatcaa agaggcaacc
     3661 ggaaatgttg cacaggcagc aaagaccatg tatttaacgg atggaaagct tgatctgtat
     3721 tccggcgagg atggaatcgt agtaccgtta atgtcgatcg gagcaatcgg tgtgatctcc
     3781 gtatggtcaa acgtggcacc gaaggatgta catgatatgt gtatggcatt ctttgacgga
     3841 gatacgaaaa aagcaatgga gatccagcta aaggcacagc cgctcattga ggcgctgttc
     3901 tccgaagtga acccgatccc tgttaagaaa gcgctgaatc tgatgggcat ggaggcagga
     3961 ccgcttcgtt ccccgctcac agagatgaca gatgccaatg ctgcaaaact tgcggaagca
     4021 atgaagaatt atgggatcaa gctggcgtaa ggggcagtgg aacacggaaa gccagatttg
     4081 aaaaaacacc ggaaatgttg gttcgcagcg tttccggtgt tgctttaaat aaagaaaaga
     4141 gaggaaaaaa caatatgata agagcaatta tgagtggatg caacggaaaa atgggacagg
     4201 tgatcacagg gatctgcaag gaggatgcag agattgagat cgtggcagga atcgatctct
     4261 acgatggcat caaaaacgat tacccggtat tccccaatat ctctgtctgt gatgtggcag
     4321 cggatgtgat cattgatttt tccaacgcaa aagcagtgga tgatcttttg gtatatagtg
     4381 tggacaagca gatcccggta gtactctgca cgacaggact ttctgaggag cagttaaaaa
     4441 aggtggacga ggcatcgaaa aaagttgccg tattaaaatc tgccaacatg tcgcttggaa
     4501 tcaatatgtt aatggagctg ttaaaacagg ctgcaaccat tttagcaccg gccggttttg
     4561 atatggagat cgtcgaaaaa caccacaacc agaaactgga tgcgccgagc ggtacggcac
     4621 ttgcacttgc cgattccatg aatgaggcac ttgacaatgc atatacctat acttatgacc
     4681 gcagcaaaga gcgcaaaaag agagaaaaaa cagagatcgg tatctctgca gtgcgcggcg
     4741 gcagcatcgt aggagaacat gaggtgatct ttgcaggact tgatgaggtg atcgagttta
     4801 agcatactgc atattccaga agtgtatttg caaaaggagc tgttcaggca gcaaaattct
     4861 tatctggcaa accggctggt ttctatgata tgggggatgt gatcaaggct acgatcgcgt
     4921 agagcattga caataaatta acgttggttg cccccgctca tttcctatga taagataaaa
     4981 aagcagcaaa tgaacgtgaa aaagaaatga ggaatactat ggggcagacc gacctgcgtt
     5041 atttaaaaag tttatcaaat cagtatccga ccattgccac agcggcgaca gagattatca
     5101 atttacaggc gattcttagc ctgccaaaag caacagaaca ttttatcaca gatgtgcacg
     5161 gggagtacga ccagttttta catgtgctaa aaaatggatc cggtgccatc aagcggaaaa
     5221 tagaggatga atttggcaat gcaatcagcg cggcggagaa aaaagcgatc gccacgctga
     5281 tctattaccc ggaacagaag ttggaacagg tgttaaagac ggaagataat ttggaggact
     5341 ggtacaaagt caccttatac cgcctgatcc gcatctgtaa aaatgcatct tccaagtata
     5401 caaggtcaaa agtgcggaaa gcacttccaa aagactttgc ctatgtgatt gaggaacttt
     5461 tgaccggcag acaggagata tccgatcagg aggcatatta taatgaaatt atccggtcgg
     5521 tcatccgcac cggaagggcg gcggagcttg tgatcgcgtt ctgtaatctg atccgccggc
     5581 ttgttgtgga tcatctgcat gtggtcgggg atatttttga caggggacca tatccgaatc
     5641 tgatcatgga cacactgatg gagcatcact ctgtggacat ccagtggggc aatcacgatg
     5701 tgtactggat gggagcggcg tcgggcagtg cggcatgcat ctgtaatgtg atccgcattt
     5761 ctgcaaaata tggaaacctt gatctgttag aggacggtta cgggattaat ctggtgccgc
     5821 tggcaagatt tgcgatgaag tggtatgata aggattcctg tgactgtttt aagctggatt
     5881 accgggaaga tgaatatgat gtgcacgacg catttttaga tgaaaaaatg cataaggcga
     5941 tcacgatcat gcagtttaaa ctggaaggtc agctgatcaa agaacacccg gaatttgaga
     6001 tggagaaaag acttcttctc gataagatca acatcgaaaa ggggaccgtg tgtgtggagg
     6061 aaaccgagta tccgctcaag gatgtcagtt ttccgacaat cgactgggaa gatccatatc
     6121 gtctctcaga agatgaggcg gatgtgatgg agcgtcttgt gactgcattt gtgaactgtg
     6181 aaaaactgca gcgtcatgtg cgttttttgt atacacaggg aagtctttac aaagtatata
     6241 atggaaacct tctctaccat ggctgcgtgc cgctgaatga ggatggcacg tttaccagag
     6301 ttaacgtttt tggaaaagaa tatgccggaa aagagcttta tgatgtgctt gagggctacg
     6361 cgcgaaaagg ctattatgcg atcgacccga aggagaagaa aaagggacag gacattttat
     6421 ggtttatctg ggaaaaccag aattccccgg tgtttggaaa ggcaaagatg acgacgtttg
     6481 agcgttattt tattgcagat aaaaaaacgc atcaggagcc gaaaaatcct tattacaggc
     6541 tgcttgaaaa agaggaagtg gtcaaccgga ttttagagga attcgggctt gaaggtgcgg
     6601 aggcgcacat cattaacggt catattccgg tggaggcaaa aaaaggagag tctccggtca
     6661 aatgtaacgg aaagcttctg atcattgacg gcggtttttc caaggcatat cagccaaaga
     6721 cagggattgc cggatatacg ctgatttata attcttatgg tctggtgctt gcggcgcatg
     6781 aaccgtttga atcggtagaa aaagcggtgc aggacggaag cgatatcgta tcccatacgg
     6841 ttctggtgca gcaggtcgtg cggagaaaaa cggttgccga tacagatatc ggaaaaagtt
     6901 taaaagagtc gatccatgat cttgaggagc tgctcgcggc atacagagcg ggcacgatcg
     6961 tggagaagaa ccgggcagaa taaaagagca ttcgcgtata cagacaggag tattattgtg
     7021 cacaaaatta aggtgcgcga agcgcagtgc agaaatgagg attgatatgt taataggaaa
     7081 tcatttatcc gcatccaaag gatatgcggc gatgggaaag gcagcgctgg cgttagatgc
     7141 caataccttt gcttttttta caagaaatcc gcgtggcggt aaggcaaaag aaatcgatga
     7201 aaaagatgtg gaaaagtttt taaattttgc gaaggagcac gaatttggaa agattgttgc
     7261 gcatgcgcca tatacgatga acctctgcgc tgcaaaagag gatgtccgtt ctttttcaaa
     7321 ggaaatgctg cttgatgact taaaacgcat ggagtataca ccgtacaatt attataattt
     7381 tcatccgggt tcccatgtgg gacaaggggc ggaaaaaggg atcgcattga ttgcggaagc
     7441 attaaatgaa gccttgaaac cggagcagac aacgaccgtt ttacttgaga cgatggcggg
     7501 aaaaggaact gaggttggaa gaacgtttga ggagttaaga gaaatcttag accgtgtgga
     7561 attaaacgat aaaatgggag tctgcctcga tacctgccat gtgtgggatg gcggttatga
     7621 cattgtaaac gaccttgacg gtgtgttaaa tgagtttgac cgtgtgatcg ggctcgaccg
     7681 gctgaaggca gttcacttta atgacagcat gaacgactgt ggctcccaca aggaccgtca
     7741 tgcgaagatc ggtgagggaa agatcggtgc agaggcgatg cggcgcgttg cattgcaccc
     7801 gcttttagaa ggaagaccgt ttatcttaga gacaccgaac gatgatgagg ggtacagacg
     7861 ggagatacag atggtccggg agtggacgcg gtaagatcgc tgcaaacctg aatagaaaat
     7921 aaaaatatcc taaaacgaaa taaaaaagaa aataccagaa ttttacagaa tacgttattg
     7981 catttgccat gtgtgtatgc tatacttcaa atcacatgaa tgcgaaaatt gttttcatgc
     8041 aaatattcgt tacaatagat ggaaaaggat ctattgtttg cccaccaaga gattggttaa
     8101 gcccatacgg acaggcgggg caactgccga ttgcggtgta agccgcgtta ttgattgagt
     8161 tagaagctca aattttataa gttgattacg gggatgatac ccggaatcca atatcacttg
     8221 tgaaacggtc aataagagta gtatacgcaa atatttgctg gcaaagatgc caacgcggac
     8281 tctggagaaa atagtttttg cagaatgtag atagattaca taaagtatga ctatgatgat
     8341 aacgacgata gaagaacagg tgatggatgc ctgttctttt tttgcgtttt tcagcctgac
     8401 ggtaatgtca gggaaaaaca tttgatgaaa agcagagcat gcagattttt atggaagcca
     8461 agggggattt ttttagtcat ggacaaagag cagcagatgc gtgcgccggt ttatgaggca
     8521 ctggaaaagt taaaaaaacg aagagtggtg ccgtttgatg tgccgggaca taagagagga
     8581 aggggaaatc cggagctggt agagctgttg ggagaaaaat gtgtgagtct ggatgtcaat
     8641 tccatgaagc cgcttgacaa tctctgtcat ccggtttcgg tgatcaagga agcggaggag
     8701 cttgccgcgg aggcatttcg cgcggaacat gcatttttta tggttggcgg aaccacttcc
     8761 tccgttcagg gaatggtgct ttcctgctgt aaggcagggg ataagatcat tttgccgcga
     8821 aatgtgcaca agagtgtgat taatgcactg gtgctctgtg gagcgattcc agtttacgtc
     8881 aatccggagg ttgatgtgaa acttggcatt tcactgggaa tgcaggtgtc agaggtggaa
     8941 cgtgcgattt tagagaaccc ggatgcagta gcagttttag tcaacaatcc gacttactat
     9001 ggaatctgtt cggatctgcg gtctatcgtg agagtggcgc atgaacatca tatgctggtg
     9061 ctggtggatg aggcacacgg aacgcatctg tattttgggg aaaatcttcc ggtatgtgcc
     9121 atggatgccg gggcggatat ggcgtctgtc tccatgcaca agtcgggggg aagcctgacg
     9181 cagagctctc ttcttctgac cggaaagggt gtgaactggg aatatgtcag ccagatcatc
     9241 aatctgacgc agacgacgag tgcatcttat cttctgatgt cgagccttga tatttcgcgg
     9301 agaaaccttg ccttgcgagg gaaggaatct tttgcgaaag tggcacagat ggcggagtac
     9361 gcgagggatg agatcaattc tatcggtgga ttttatgcgt atggcaaaga tatggtaaac
     9421 ggtggcagtg tctatgattt tgatgtgaca aaactgtctg tatatacgag agatatcggg
     9481 cttgcaggca ttgaggtcta tgatctgctg cgggatgaat atgatattca gatcgagctt
     9541 ggagatatcg caaatattct tgcctatatt tccatcggtg accggataca ggatattgag
     9601 cggcttgtgg gtgcacttgc agacatcaaa cggctgtatt cgaaagatcc ggcaaaaatg
     9661 ctgaatacgg aatatattaa tccgaaggtt ttagtgtcgc cgcaggtggc attttattcg
     9721 caaaaggaat ccatgccggt tcgtcagaca gcgggaagga tctgcggtga atttgtcatg
     9781 tgctatccgc ctggaattcc gattttagca ccgggtgaga tgatcacgcc ggagatcatt
     9841 gagtacattg tttatgcaaa agaaaagggg tgctccatgc agggaacgga ggatccggaa
     9901 gttgaaaatc tgaatgtgct tgcaaagaaa taacagcata gatcagcaaa aataaagatt
     9961 cctgtgaaaa gaagattttt tcaaaagaag ggggaagatc atggaacttt ggttttcgga
    10021 ttaccacacg gaaaaagtca aggtgtcggt caaggtgcag aaacagttat ttggtttaca
    10081 gaccgagttt cagcggatcg atgtgtttga ttcggatgag tttgggcgtt ttttaagttc
    10141 cgacggcagt attgtttttt cggaaaaaga tgagtttgtc tatgatgaga tgatcgtgca
    10201 tgttccgatg gcggtgcatc cgcatgtgaa aaaggtgtta gtcatcggcg gcggtgacgg
    10261 cggcgtggca cgagagcttg gctattacga tgagatagag cagatcgatg tcgtggagcc
    10321 ggaccgtgta tttgtcgagg tctgcaagga attttttccg gacaatgcgt gcgggttatc
    10381 ggatgaacgc gtgacggtat actatgagga tggattgaaa tttttgcgga tgaaacatga
    10441 cgagtatgat ctgatcatca acgatgcgat tgatccgctt ggacatactg caggactgtt
    10501 taccaaggaa ttttacggaa actgcttccg tgccttaaaa gatgacggaa tcatggtata
    10561 tcagcatgga agtccgtttt acgatgaaga tgaggaatcc tgccgcggta tgcaccggaa
    10621 agcaagtcat agctttccaa tcagccgcgt gtatcaggca catataccga cgtgttcttc
    10681 cggctactgg ctgttcgggt ttgcgtcaaa gaaatatcat ccgctcgatg atctggatgc
    10741 aaagcgctgg aaagagcgga agataaaaac ctggtattat accaccaatc tgcacaaggg
    10801 agcatttatg ctgccgcgat atgtggagga tatgttagag gaagaagaag gacgtaagaa
    10861 ataataaaaa ttaaattaaa atttattttt tcacacgcaa gatttgtgcc ccggcacaaa
    10921 cttgagatgc gcaaaaagac agcgcaggaa aggagattaa aatgggaaga ttattaatta
    10981 tcggatgtgg cggagttgca ggagttgcga ttcacaaatg ctgccagaac agcaaaactt
    11041 ttacggagat ctgcattgcg agcagaacaa aatcgaaatg tgacgcctta aaagagaaac
    11101 tggaaaaaac aacggacact gtcatcacaa cagcacaggt ggatgcggac aatacggagg
    11161 aactgatcgc cctgatcaaa aaatatcagc cggatgctgt gttaaatgtt gctttgccat
    11221 atcaggattt aacaattatg gatgcctgcc ttgcatgcaa agtagactat atcgataccg
    11281 caaattatga gccggaggat acggatgaca aagaatggcg tgccatctat gaaaaacgct
    11341 gtaaagaaga gggatttaca gcatattttg actattcctg gcagtgggca taccgtgaaa
    11401 aattcaaaga ggcaggaatt acggcattgc ttggaagcgg gtttgatccg ggagtgacca
    11461 gtgtatttac cgcttatgcc ctgaaacatt atttcgatga gatcgagacg attgatatct
    11521 tagactgtaa cggcggcgac cacggctatc cgtttgcaac caattttaac ccggagatca
    11581 acctgcgtga ggtttccgca aacggttctt actgggagaa tggtcactgg gtagaaacaa
    11641 aaccaatgga aattaaaaga gaatataatt tcccacaggt tggcgagaaa gatatgtatc
    11701 tgctgcatca tgaggaaatt gagtcccttg caaaaaatgt acctggagta aagcggatcc
    11761 gtttctttat gacctttgga cagagctatc tgacacatat gaaatgttta gaaaatgtcg
    11821 gaatgctctc aacatcaccg atcgagtatg agggcaggga gatcgtaccg atccagtttt
    11881 taaaggcgct gcttccggat cctgcatcat taggaccgcg cacggttgga aaaacaaata
    11941 tcggctgtat ctttacggga aaaaaagacg gaaaagaaaa gacgatttat atctataatg
    12001 tctgtgacca tcaggaatgt tacaaagaag tcggttccca ggcaatttct tatacaacag
    12061 gtgttccggc tatgatcggt gcagcgttag ttgtcgataa agtctgggac aaagacggtg
    12121 tattcaatat tgaagagttt gatccggatc cgtttatgga tatgttaaac cagtatggtc
    12181 tgccatgggt tgtggacgaa aatccgcaga cggtggcata aaataagaat atgtgtgaaa
    12241 cgggttggat aaaattttaa atttgtcagc ttttgcgcag cggatttttg cagaaatgga
    12301 gaattatcat gaaatggcag gagattccta ccccgtgtta tgtggtagat gaaaagaagc
    12361 taaaacaaaa tttaaaaata ttgcagaatt tggaacagga aaccggctgc catgtgcttc
    12421 tggcacagaa ggcattttcc atgttttcac tgtatccgct gatcgggcag tatatcagcg
    12481 gaacgacggc gagcggaatc tttgaggcgc gccttggaaa agaggagatg ggaaaggaaa
    12541 atcatgtatt tgcaccggct tataaggaaa aagatatgga agaactggtg cagatctgcg
    12601 atcacgttat ttttaattcc tttgcgcagt atgaaaagta tcagcactat tttttgcagc
    12661 aggagtgcac tgcaagtgcc gggatccgcg tgaacccgga gtgctccaca caggaagggc
    12721 atgagatcta tgatccatgc ggaccgggat caaggcttgg tgtggttaaa agtgaatttc
    12781 cggatcaact gccggaggga atcgaaggat tacattttca tacactctgc gagcagaatg
    12841 cggatgatct gatcacgacc tggcatgcgt ttgaggagaa gtttggcagt tatttaaaac
    12901 aggtaaaatg gctgaactta ggcggcggtc atcatattac aagagcagac tatcagttgg
    12961 atgaattaaa gaagttaatc tgtgagatca ggcgaaaata taatgtccgg gtctacttgg
    13021 aaccgggtga ggcgatcgca ttaaatgcgg gctatcttgt cacggaggtt atggatatcg
    13081 tacacaatgg aatggatatc ctgattctgg atgcatcggc ggcatgccac atgccggatg
    13141 tgcttgaaat gccatataga ccgccgctaa aagacggtta tctgccgggc gaaaagccgc
    13201 atacctgccg gctttcttcc atgacctgcc ttgccgggga tgtgatcggt gattacagct
    13261 ttgcacagaa aaaacaggtg ggagaccgtc tggtctttga ggatatggca atttattcca
    13321 tggtcaaaaa caatacattt aacgggatgc cgctgcccgg aattgcagtc ttacgggaag
    13381 atggagatgt cgagatgata aaggagtttg gttatgaaga tttcaaaggc agactgtcct
    13441 gagatgataa aagatacaac accggtacag gacggatttt tcatgccggg tgagtttgag
    13501 cagcatcagg gatgtatcat gatctggccg gagcgtcccg gttcctggag aaatggcgcg
    13561 aaggaagcag aaacagcgtt ttcagctgtg atccgtgcaa tcgccgcgag tgagacagtg
    13621 tatgtcgctg ccggaaaaaa ggggattgac catgcaaaag catttgcgga aagtctgaaa
    13681 aaagaagaaa acttacatcc ggtggttgtc tttgagatgg agaccgatga ttcctgggcg
    13741 cgggatgttg cgccgacctt tctggtaaac agaacggatg gaaagatttc agacctgaca
    13801 gcagcaggaa atggtacggc gcagacaggt gatgatgtaa aaaactcaca ggtgcgcggt
    13861 gtaaactggt cttttaatgc ctggggcggt gaagtggatg gactatatgc ttcttatgaa
    13921 aaagacaatg cgtttgcatg gaatttctgc agaaaattcg agtttgactg ttatgatgcc
    13981 gaaccgtttg tgttagaggg cggttctatc cacagcgacg gagagggaac attgcttgtc
    14041 acggagtcct gtctgctcag tgcggggaga aacccatcgc ttacaaagga gcagattgaa
    14101 gaacagttaa agtgttacct tggcgttgag aaagttttat ggctgccacg cgggatctat
    14161 caggatgaga ccaacgagca tgtggacaat gtctgtgcat ttctaagacc aggtgaagtt
    14221 gtgcttgcat ggaccaataa ccagaatgat ccgcagtatg cgatgtcgaa agcgagtttt
    14281 gagtatctaa gttcggtgcg ggacgcaaag gccagaaagc tgatcatcca caaacttcca
    14341 attccggata ttccggtctg tatcaccaaa gaagaactcg aaggatacga atttgaggaa
    14401 ggtgaagatg tcagggaagt cggagaacgg ctcgccgcct cctatgtaaa cttttatttt
    14461 tccaacaatg cggtagtcat gcctgtattt ggcggagaaa acgaagaaag cgacctgcgt
    14521 gcacagcaga ttatggcaaa actctgcccg gacagaaaaa tcataccggt gtacgcaaga
    14581 gacatactga caggcggtgg aaacatccac tgtattacac agcaaattcc cttataggga
    14641 atttattgta caaccttccg tataggagaa ttaattcact gtgcaaaaat aaaaagaaca
    14701 gaaaggatac acgcatgaga cagataaaag cagccgcaat tcagatgaaa tgcgacttgg
    14761 agcacaagaa aaacttacaa aaagcagaac aaatgatccg caaagctgcc gcggaaggcg
    14821 caaatatcat tttactgccg gaactttttg agcgggaata tttctgccag cagcgcagat
    14881 atgattttta cagctatgca agaactgtgg aggagagtga agctgtggca atgggagtac
    14941 gtcttgcaaa agaattgggc gtggtgcttc caatcagctt ttatgagcgt gatgtcaata
    15001 atctctataa ttcgatcgca tgcattgatg gagatggaac gatcctcggt gtgtatcgga
    15061 aaacccacat cccggatgat cattattatc aggaaaaatt ttattttaca ccgggagata
    15121 ccggatttaa agtgtttgat acaaaatacg gttgcatcgg tattggaatc tgctgggatc
    15181 agtggttccc ggagacagcg cgtgcgatgg cgctgctcgg tgcagaatta ttgttttacc
    15241 cgacagcgat cggctcggaa ccgattttag aatgtgacag tatgccgcac tggagacgct
    15301 gcatgcaggg acatgcggct gcaaatctga tgcctgtcat tgccgcaaac cggatcggca
    15361 gggaagtagt gcagccatgt gcggaaaatg gcggacagga gtcggcactg gaattttatg
    15421 gttcctcatt tctgacggat gaaacaggag aggtgatctt aagtgcttcc agagataaag
    15481 aagaaatcct gagccagacc tatgaactgg atgaacttcg ggcaaaacga ctggaatggg
    15541 gactt
//
