LOCUS       gnlProkkaAMEPOAEB_121  11558 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AMEPOAEB_121.
ACCESSION   gnlProkkaAMEPOAEB_121
VERSION     gnlProkkaAMEPOAEB_121
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 02:44:53
            Original ID  :: gnl|Prokka|AMEPOAEB_121
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11558
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11558
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3086:4752]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3087..4752
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11558
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11558
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             140..940
                     /locus_tag="ctg121_1"
                     /transl_table=11
                     /translation="MKTALTIAGSDSSGGAGIQADIKTMTANGVFAMSAITALTAQNTT
                     GVTAIFDTTPQFLAQQLDAVFTDIYPDAVKIGMVSSAPLIDTIAERLHFYGAKHIVVDP
                     VMVATSGAKLLQDDAVQALTEKLLPLAEVLTPNIPEAEILSGMSIANAADMEAAARTIS
                     ERYGCAVLCKGGHQINDADDLLWRNGTGKWFKGKRIANPNTHGTGCTLSSAIASNLAKG
                     YDLDTAVERAKAYISGCLSAMLDLGHGSGPMDHTFNLKGDFVRD"
     CDS             933..1610
                     /locus_tag="ctg121_2"
                     /transl_table=11
                     /translation="MTDLPFVSALVQADLPVWEQCLQAEFLQKMENGTLSEDCFKSYLV
                     EDSLYLREYAKIFAWGMTKATTMAAMRTYYSLLSFVQENEDLTRLRYLEQYGLREADIQ
                     SLPLRPESRAYLDCMIDAARTGEGEAECLMACLPCMLSYGWLFQKLLQRSPAVKDTYYG
                     ALVLDYAGPGYDAACRAWAERAEAACTGLSPERAARCRAIFRACSEHELRFWEMCAAPR
                     TDI"
     CDS             complement(1672..3090)
                     /locus_tag="ctg121_3"
                     /transl_table=11
                     /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG
                     ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQSAPQNGKRPVLL
                     AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHAMAQQGNTPFG
                     VYVTSPDYLGGVQDIPALAAVCRAQGVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS
                     AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSPSYLILQSLDACNAVLAGDY
                     PRRLVQCCVALEGLRRSLNKAAAARQCPVPLAVAGAQQEPMKLTLDAAALGCTGTTLAE
                     ALRRAQLECEYADPRYVVLMFTPENPPQDYTRLQTALEQLLAAVPAGLPRPENRAGEFA
                     ALQQQAVQRCTIRQAVLGAQVRIPVHKALGRVCAMPTVSCPPAIPVAVSGEEITPAAIA
                     LMQRYGIEELSVLR"
     CDS             complement(3087..4538)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.9e-31,
                     bitscore: 97.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.2e-16, bitscore: 48.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.9e-17, bitscore: 52.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-20, bitscore:
                     63.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVA
                     AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH
                     VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM
                     NFDMVKKLVAYCREQEKIHNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV
                     NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHFNTDFTNDIFHMADLGFT
                     ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA
                     YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL
                     AAKGIEVPIELGSTCNACADGEACE"
     CDS             complement(4606..4752)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_5"
                     /sec_met_domain="TIGR03973 (E-value: 1.2e-26, bitscore:
                     82.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 6.9e-26, bitscore: 79.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERIKTIATRDLTKSVKTGGCGECQTSCQSACKTSCGVANQQCEN
                     SNK"
     CDS             complement(4873..5160)
                     /locus_tag="ctg121_6"
                     /transl_table=11
                     /translation="MPERTTQNAQTLLSPRVPRDTEHERYHPELEEELKECLFCLKRNE
                     MMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHTVLTRYQPMGG"
     CDS             5644..5748
                     /locus_tag="ctg121_7"
                     /transl_table=11
                     /translation="MVKEQSKSQNAVDLYDPTGEKRIQKSPQAFLNPE"
     CDS             complement(5893..7653)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 251.1; E-value: 4e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg121_8"
                     /transl_table=11
                     /translation="MKQLISRRSFLKAAGVTAAAASMAIGAPAASACWLGDKSDVTILY
                     TNDVHTYIDKQSPKLTYAAIADLKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIK
                     LMNAAGYDVATPGNHEFDYGMDRAKAIMKEADFPYLSCNWVDLRTGLRVLPSVKVFVRG
                     GRRIAFVGVTTPETFTKSTPAYFMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLA
                     DVVIGLGHLGVDPSSSPWTSEEVIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQ
                     TGSYFANVGEMTIAADGTITTKLIPTYEGMDATIAAMQTGWVNTVDDMLGEKIAVGDSD
                     FYVSDPATGKRRIRSAETNLGDFVADGIYAYFNEVEKLHCDLAIMNGGGIRADVPAGDW
                     TFKTCKQISPFGNVACLMSVTGKQIQDALEFAARFAGEGGKENGGFLQVAGATYEIHTD
                     IPNTVQTDEKNVWIGSATGTPRVQNVKIYDKASGSYLPLDPGATYALAGMNYTLRNLGD
                     GFAMFDGAELIKDYVSEDYLVMSTYAMIFDGADAAGLPHLSSTNSPLAAYPGYLLDYEQ
                     PYGAGRITIL"
     CDS             complement(7943..9715)
                     /locus_tag="ctg121_9"
                     /transl_table=11
                     /translation="MYYSSGNYEAFATPKKPEGVDHKSAYIIGSGLAALTAACYLVRDG
                     QMKGEHVHVFEKNALAGGACDGYKYDIGYVMRGGREMDNHFEVMWDLLHSIPSLETEGA
                     SVLDEYYWLNKEDPNFSLCRATVNCGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDK
                     KITDFFDDEVLNTNFWMYWRTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRY
                     NQYESIILPMVRYLESFGVQFHYNTKVTDVKFDIQKGRKLASSVTVEHAGETSNIDLTE
                     NDLLFITNGGCVESCTVGAQNKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEP
                     ELSNWESATITTLDDKIPQYIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQF
                     KDQPKNQLCVWVYGLFSDKPGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSA
                     NTVPVMMPYIDAFFMPRAMGDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGME
                     AVYTLLNIDRGVPEVWGSTYDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIE
                     GTDLEKFLKEYNAI"
     CDS             complement(10082..10345)
                     /locus_tag="ctg121_10"
                     /transl_table=11
                     /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTIASIEVIGGCNGNLKGICQ
                     LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEEMN"
     CDS             complement(10351..11211)
                     /locus_tag="ctg121_11"
                     /transl_table=11
                     /translation="MSCDLHIHSTCSDGAVPIERLASIAARTGLHAIALSDHDTLLSAQ
                     YAYAHTGQDGVELIPAVELTGYDFERQHRVHLLCYYPDVDCPALREHCAVMKERRNACA
                     LQSAKELEQLYPQFTTDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGW
                     NPRGIVLHSPEYLPVRQVLATAKASGGAVVFAHPTVYKSMPLLRELAAEGAVDGIEVYH
                     PSNSAEDSAECLALCKQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAAAQLRAIAEKR
                     KRERT"
     CDS             complement(11226..11558)
                     /locus_tag="ctg121_12"
                     /transl_table=11
                     /translation="MGSAREQAASCQRVLGAGANIVTEYATKRYRSNLINWGMLPLQLA
                     GATPFGLGDYVLIPNVREALKGDLQSIKAYVLGDTVKEFELYMAPLTTDERQILADGCL
                     INFYKH"
ORIGIN
        1 aagcgggctg agagtgggct gtattgccct gacctgtgac ctgatttgga tcatgccaac
       61 gtagggagat agcgctttta tctgcggata tgtctttgcg ggcatatccg catctttgct
      121 gtaaaggagc attttaccca tgaaaactgc attgaccatt gccggcagtg attccagcgg
      181 cggcgccgga attcaggccg atatcaagac catgaccgcc aacggcgtgt ttgccatgag
      241 cgccattacc gccctgacgg cacagaacac caccggcgtg accgccattt ttgacaccac
      301 accgcagttt ctggcgcagc agctcgatgc cgtgttcacc gatatttacc cggatgcggt
      361 aaagatcggc atggtatcct ctgccccgct catcgacacc atcgccgagc ggctgcattt
      421 ttacggcgca aagcacatcg tggtggaccc tgtgatggtg gccacctccg gtgcaaagct
      481 gctgcaggac gatgctgtgc aggcgctgac cgaaaagctg ctgccgctgg ccgaggtgct
      541 tacccccaac atcccggagg ctgagatctt gtccggtatg agcattgcaa acgctgccga
      601 catggaggcc gctgcccgca ccatcagcga gcgctacggc tgcgccgtac tgtgcaaggg
      661 cggccaccag atcaacgatg ctgacgacct gctgtggcgc aatggcaccg gcaagtggtt
      721 caagggcaag cgcatcgcaa accccaacac ccacggcacc ggctgcactc tgtccagcgc
      781 cattgcctcc aatctggcaa agggctatga ccttgacacc gccgtggagc gcgccaaggc
      841 ctacatttcc ggctgtctgt ccgccatgct ggacttaggg cacggctccg ggcccatgga
      901 tcataccttt aacctgaagg gagattttgt ccgtgactga cctgcccttt gtttcggcgc
      961 tggtgcaggc cgacctgccc gtgtgggagc agtgtttgca ggccgagttt ttgcaaaaga
     1021 tggagaacgg caccctgagc gaggactgct ttaaaagcta cctcgtagag gacagcctgt
     1081 atctgcggga gtacgccaaa atttttgctt ggggcatgac caaggccacc accatggctg
     1141 ccatgcgcac ttactattcc ctgctgtcct tcgtgcagga gaacgaggac ctgacccggc
     1201 tgcggtatct ggagcagtac ggtctgcggg aagctgatat ccagtccctg cccctgcgcc
     1261 cggaaagccg cgcctatctg gactgcatga tcgacgctgc ccgcaccggc gagggggaag
     1321 ctgagtgcct gatggcctgc ctgccctgta tgctgagtta tggctggctg ttccagaagc
     1381 ttttgcagcg ctcccccgcc gtaaaggaca cctactacgg cgcgctggtg ctggactacg
     1441 ccggtcccgg ctacgatgcc gcctgccgtg catgggcaga gcgcgccgag gcggcctgca
     1501 ccggcctttc gccggagcgt gccgcccgtt gccgcgcgat cttccgcgcc tgctcggagc
     1561 acgagctgcg cttctgggag atgtgcgccg caccccggac ggatatttaa gaataaatat
     1621 agagaacccg gaaggtctgc ggactttccg ggttctcttc ttataaaatc tttatcgcag
     1681 caccgagagt tcctcaatgc cgtagcgctg catcagggcg atggccgccg gggtgatctc
     1741 ctcgccgctg accgccacag ggatggcggg cgggcaggac accgtaggca tagcgcacac
     1801 ccgccccagt gccttgtgca ccgggatgcg cacctgtgca cccagcaccg cctgccggat
     1861 ggtacagcgc tgcaccgcct gctgctgcaa ggcggcaaac tcccctgccc ggttctcggg
     1921 gcggggcagc ccggcgggta cggcagccag aagctgctcc agcgccgttt gcaggcgcgt
     1981 gtagtcctgc ggtgggttct ccggggtgaa catcagcacc acatagcggg ggtcggcgta
     2041 ctcgcactcc agctgtgcgc ggcgcaaagc ctctgccagc gtcgttcctg tgcagccaag
     2101 ggcggcggca tccagcgtga gcttcatcgg ctcctgctgt gccccggcaa ctgccagcgg
     2161 caccgggcac tgccgcgccg ctgcggcctt attcaggctg cggcgcagac cttccagcgc
     2221 cacgcagcac tgcaccagcc gccggggata gtcccctgcc agcaccgcgt tgcaggcatc
     2281 cagcgactgc aaaatgaggt aagaggggct ggtagagccg aacagcgcca gcgcgccccg
     2341 cacagccgct tcgtcctgca caggggcatc gtgcgccaga tgcagatacg caccgccggt
     2401 gaccaccggc agggtcttgt gggcagagtc gcagcacatg gccgcaccct gcgcgatggg
     2461 gtgacagttc tgcggcaaaa agcgcagata ggcgccgtgg gcgttatcca ccagcaaagg
     2521 cacgccctgc gcccggcaga ccgccgccag cgccgggata tcctgcaccc cgcccagata
     2581 atccgggctg gtgacgtata cgccaaaggg ggtgttcccc tgctgtgcca tcgcgtgcaa
     2641 agcccctgtc agcgcttcgg ctgtgacggg gcagctgcac agtgcaccct ctgcctgcgc
     2701 agacggccaa agccagcgga tatcaaaatc cagcagcgcc gccgcgtaca gcagcgcctt
     2761 gtgggcgttg cgggcagcca gcagcaccgg gcgcttgccg ttttgcggtg cgctttgcag
     2821 cgccagaaac agcatggcac ggatgcactg agacgagcct tcggtgctgt aatagctgtg
     2881 cgccgtgccg aacagccggg tggcgttggc ttcactctcg gcaataatgc cctccggcgc
     2941 gtaaagctcg tctgcgccgc agatctcggt gatatccagc ggctcaaagc ctaaaaggct
     3001 ctgccccttg tggccgggca tgtgcagccg ggcggtgccg gactttgcat agctgcgcac
     3061 aaaatccacg atgggggtgg tcatgctcat tcgcaggctt cgccatcggc gcaggcgttg
     3121 caggtagagc ccagctcaat gggcacctca atgcccttgg ctgccagttc ctgattctcg
     3181 gctaccttga tcatgatagc gcactccatg cgctttttga acagctcgca gccgtactcg
     3241 tacacgccgg taatgctgcc ggtggcgtgg taggagttgg cagcgcagcc gccggagcag
     3301 tacagctttg cccagcagtc ctgacactcc ttgcgggcgt aggcgttgca gtgcttgaac
     3361 tcatcccgca cagcggtgtt ggtaacgccc ttccagatat cgcccagcag gtacttgggg
     3421 tcacccacga actggtggca ggggtacaga tcgccccaag gggtaacagc catgtactcg
     3481 gtgccggagc cgcagccgga gatgcgctta tagatgcagg ggccgccggt caggtcgatc
     3541 atgtagtggt agaaggtaaa gcctctgccc tcgcggtcgc gcttaatcat ctccttggca
     3601 aggatctcgt actgctcctt caggatgggc agatcggcct cggtcagggc gctggggtcg
     3661 ctggggtcgc agaccaccgg ctccatgctc agctcggtaa agccgaggtc tgccatgtgg
     3721 aagatatcgt tggtaaagtc ggtgttaaag tgggtatagg tgccgcgcat atagtagttc
     3781 ttgtcgccgc gcttcttgac gaactcctgg aacttgggca cgatgcggtc gtagctgccg
     3841 ttgcctgcac agtccacgcg gaagcggtcg ttgacctcct tgcggccatc cagactcagc
     3901 accacgttgt ggcactcctt gttgcagaag tcgatgacat cgtcatcgat cagcacgccg
     3961 ttggtggtca tggtaaagcg gaagttcttg ttgtggatct tctcctgctc gcggcagtag
     4021 gccaccagct ttttgaccat atcaaagttc atcagcggct cgccgccaaa gaagtccact
     4081 tccagattgc ggcgggtgcc gctgttctcg atgaggaagt ccatggcgcg cttgcccacc
     4141 tcaaagctca tcagggcgcg gtcgccgtgg tagcgtccct gcgaggcaaa gcagtaagag
     4201 cagctcaggt tgcagctgtg ggcaacgtgc aggcacagtg cctttaccac agtgttgcgg
     4261 ttcttgaagt caaaggccat gtccttatag acatccgggc tccacagctt gccgttttcc
     4321 ttcaggctgg tcacatcgtc gatgcactgg cgcagatcct cctcggtcac gtccgggcgg
     4381 ctgccgtact ttgccagcat ggcggcaacg atctcgtctg cggtatgctc cgggtacatg
     4441 gcgatgacat cgtaggccac ctcgtccaca acgtgcaccg agccgctgca ggtgtccagc
     4501 acgatgttat aaccgttcaa ttgatactga tgtaccattt tacactccat tccagattac
     4561 acaaaaaaat gccgcccggc aaaggcggca taaggtttgc aaaaattact tgttgctgtt
     4621 ctcgcactgc tggttagcca cgccgcagga agtcttgcag gcggactggc aggaagtctg
     4681 gcactcgccg cagccaccgg tcttaacgct cttggtcagg tcacgagtag caatagtctt
     4741 gatacgctcc atgatagaaa cctctctaac tctcaaaaat ttatcgcgcc ggacatagtt
     4801 ccggtacgct tttatcttgt aataggatat cacgcagcgc agcttttgtc aagatttttt
     4861 cgctaagctc tttcacccgc ccatgggctg gtagcgggta agcaccgtat gcagtcccag
     4921 ctcccgggcg cgtgccagta agtaccggta acggcacagc agcgcctgcc gctcgtagat
     4981 gcgctgctca atgaggtcgg tatccacctc catgtcaaac atcatctcgt tgcgcttcag
     5041 gcagaacagg cattctttca gttcttcttc cagttccggg tggtagcgct cgtgctcggt
     5101 atcccgcggg acgcggggcg aaagcagggt ctgggcgttt tgtgtggttc gttccggcat
     5161 aggcatcctc cttctggtac tttgcaaggt tttgtacctt ccagtatagg cggtgcggtg
     5221 cgcagaatgt gccgaagcgt ggcagtgctc cggcacagat tatccggcgc tgctgcggca
     5281 ttttccaaaa aagtacaact tttttcaaaa atatgcttga caactccggg cttttcccgt
     5341 ataatagcac acgttgagcg gctcaccccg caaaacacaa cagaatattg gggatttgca
     5401 tagtggtagt gcggtagact ctgactctac ttgtgggagt tcgattctct catccccaac
     5461 cagaacaaag ccatctgagg aaactcaggt ggcttttctg tttgcattat tctgcgcggc
     5521 gcaacgattc agaatgccct ccgctttgct ctgggcattt tcagcggaag gattatttta
     5581 atatttcgcg tttgtcgcac tctgcggagt gctccaaacg ctattttcac aggaggggcc
     5641 gcaatggtta aagagcagtc taaatcacaa aatgcagttg acctctacga ccccactggt
     5701 gaaaagagga ttcagaaaag cccgcaggct tttctgaatc ccgaataaaa aaaccgattc
     5761 cgctaattat gcgcagagcg gagcggagcg catttccaat cgttcgtacc tgcacacaca
     5821 aaaaccgggc agcccgcaga ctacccggtt ttttgctata ccgttgattt tgccttaata
     5881 aagagctttc ttttacagaa tagtaatgcg gcctgcgccg tagggctgct cgtagtcgag
     5941 cagatagccg gggtaagcgg ccagcgggct gttggtgctg gacaggtgcg gcagacccgc
     6001 agcatctgca ccgtcaaaaa tcatagcgta ggtagacatc accagataat cctcggacac
     6061 atagtccttg atcagctctg cgccgtcaaa catggcaaag ccatcgccca gattgcgcag
     6121 ggtgtagttc atgccggcca gcgcgtaggt agcgcccggg tccagcggca gatagctgcc
     6181 ggaagcctta tcgtagatct tcacgttctg cacgcgcgga gtgccggtgg cgctgccgat
     6241 ccagacattc ttctcgtcgg tctgcacggt gttggggata tcggtgtgga tctcgtaggt
     6301 agcacctgcc acctgcagga agccgccgtt ctccttgccg ccctcgcctg caaagcgggc
     6361 tgcaaactcc aatgcgtcct ggatctgctt gccggtgacc gacatcaggc aggccacgtt
     6421 gccaaagggg ctaatctgct tgcaggtctt gaaggtccag tcgcctgcgg gcacgtcagc
     6481 gcggatgccg ccgccgttca tgatggccag atcacagtgc agcttttcca cctcgttgaa
     6541 gtaggcgtag atgccgtcgg ccacaaagtc gccgaggttg gtctcggcag agcggatgcg
     6601 gcgcttgccg gtggcggggt cggaaacata gaaatcgctg tcgcccacag cgatcttctc
     6661 gcccagcata tcgtccacgg tgttcaccca gccggtctgc atagcggcga tcgtggcgtc
     6721 cataccctcg taggtgggga taagcttggt ggtaatagtg ccgtccgcag cgatggtcat
     6781 ctcgccaacg ttggcaaagt aagagccggt ctgggtcagg gtgacagcct tgccggaagc
     6841 atcctgcacc tgcttgttct ccattacggt atgggagtgg ccgtcgataa aggcgtcaaa
     6901 gccgctggtg tgggcaatga cttcctcact ggtccacgga gaggaagagg ggtctacgcc
     6961 cagatggccc agaccgatga ccacgtctgc cagaagcttt gccttatcaa tggccttctg
     7021 cacggcgtca tagagctttt tgccgtcctc gccgccctga atgtcgtaga tgtacttgcg
     7081 ctgtgccttg tccataaagt aggcaggggt ggacttggta aaggtctcgg gggtggtcac
     7141 gcccacaaag gcaatgcgtc tgccgccgcg cacgaacacc ttgacggagg gcagcacacg
     7201 caggccggtg cgcaggtcta cccagttgca ggacaggtac gggaagtccg cttccttcat
     7261 gatggccttg gcgcggtcca tgccgtagtc aaactcgtgg ttgccggggg tggcgacatc
     7321 gtaaccggca gcgttcatca gcttgatgat ggaagcgccc tcgtccatag agccataggc
     7381 agtgccctgc acatggtcgc ctgcgtccac cagcagcaca tccttgccgg cgttctggta
     7441 actctgcttc aggtcggcaa tggcggcgta ggtcagcttg gggctctgct tgtcgatgta
     7501 agtatggaca tcgttggtgt acaggatggt gacgtcagac ttatcaccaa gccagcaggc
     7561 cgatgcggcg ggcgcaccga tggccatgga tgcagcggca gcggtcacac cagcagcctt
     7621 taaaaagctg cgacgggaaa taagttgttt cacaggaaaa cgacctcctt ttatttttgg
     7681 cgtatcgcat ttggggcagg ctcttccctt ctgccctttc aatagctcta gcatagcaca
     7741 gaacgccgcc gcagacaagc caaaatcatt cttttggcac aaataatttt cacgtcccgc
     7801 tttattttga cacacattgt accattttta cacgaatcct atacaaaaaa gacctccccg
     7861 cgccctgtcg cagagcagcg gagaggtcct ttttaggggg gattcagacc cgttaccggg
     7921 tctatcggag gagagggaaa tatcagatgg cgttatactc cttgaggaac ttctcaaggt
     7981 cggtaccctc gatcttcttc aaggcttcct tcaaagccag acgcgggatc agcggcagat
     8041 ccatgtcggt gatcttcttg ccatcgcgca gcttcacggt ggcatcgatc aaagcgcgca
     8101 catcgtaggt gctgccccag acctcgggca caccgcggtc aatgttcagc agggtgtaca
     8161 cggcctccat accggtgcgc atggagtact cggtggtgaa gatggtgtcg cgggcggtct
     8221 cggcaaactg gccaaggaag gcgaagttca cagcaccctc gggcacaaca tcgggacggt
     8281 cgcccatagc acggggcatg aagaaggcgt cgatataggg catcatcaca ggcacggtgt
     8341 tggcgctgtg ctctgccagt tcagcgatct gatcctcggg cacgccgatg tggtacagcc
     8401 actccatgca gatctcgcgg ccggtgcagt cacgcatggg ctttttgacg taatcgccgg
     8461 gcttatcgct gaacaggccg tacacccaga cgcacagctg gttcttgggc tgatccttga
     8521 actgctgctg acggttcagc gtccagctga gcagccagct ggagtccttg acggtaacga
     8581 tgccgccggt gacagtgtgg ccgctgaagg ggtcgcgctt gcagatcttg cggatatact
     8641 gggggatctt gtcgtccagc gtggtgatgg tagcgctctc ccagttgctc agctccggct
     8701 cggagcagaa cttctccggg tgaccgaaag agggatcctg tgcggcgatc ttcttccaca
     8761 gatcccagcc gttgccgggc tggatggtgg ggtcgaaacc ggtggcctta ttctgtgcgc
     8821 ccacggtgca gctttccacg cagccgccgt tggtgatgaa cagcagatcg ttctcggtca
     8881 ggtcgatgtt agaagtctcg cccgcgtgct ccacggtgac agagcttgcc agcttgcggc
     8941 ccttctggat atcgaacttg acatcggtga ccttggtgtt gtagtggaac tgcacgccaa
     9001 agctttccag atagcgcacc atgggcagga tgatggactc gtactggtta tagcgggtaa
     9061 agcgcagggc ggtaaagtcc ggcagaccgc cgatgtggtg gatatagcgc ttgaggtaca
     9121 gcttcatttc caaagcgctg tgccagttct cgaaggcgaa catggtgcgc cagtacatcc
     9181 agaagttggt gttgagcacc tcgtcatcga agaaatcggt gatcttttta tcctgcagct
     9241 gctcgtccgg ggtgaagaac agcttcatga tctccatggc acccttatcg gacaggccga
     9301 acttgccatc ggtgtgggca tcctcgccgc agttgacggt ggcacggcac aaggaaaagt
     9361 tggggtcctc cttgttcagc cagtaatact cgtccagcac gctggcaccc tcggtctcca
     9421 gagacgggat ggagtgcagc agatcccaca tgacctcgaa gtggttgtcc atctcgcggc
     9481 cgccgcgcat cacatagccg atatcgtact tgtagccatc gcaggcaccg ccggccagtg
     9541 cgttcttttc aaacacatgg acgtgctcgc ccttcatctg accgtcacgc accagatagc
     9601 aggcagcggt cagcgcagcc agaccggagc cgatgatata agcggattta tgatccacac
     9661 cctccggctt tttgggggtt gcaaaagctt cgtagttgcc actggaatag tacataaaaa
     9721 agcctccctg cttcaaaaat atcttttcac agccttcatc gtgctgttct ctatggcaac
     9781 agtatacccc gcaaagtgaa cttgaacaac aaacaaactt tgcccggtgt atagattttt
     9841 tacatccgcc ctcatttgct ggaaatgcgt acaaattgtg acataaaagc gtagcgcaaa
     9901 atcatttaaa gcattcccgc aaaagtgcaa tgccgggcag cttgcaggct gtccggcatt
     9961 gctctaattc aaaataattt tccgctattc atgcccagag catagcggcg ggcattcaaa
    10021 accgtcccac acaaaaagag agccgccgca caaaggtctg tgcagcggct ctctatcggt
    10081 tttagttcat ctcttccagt gcctttttca ggttcttggc gatctggtcc gggcagctgg
    10141 tgctgcggaa gccgcacagc gtgccatcca gacgggcaat ggcgtcctct gccttcatgc
    10201 cggtgagcag ctggcagatg cctttcaggt tgccgttgca gccgccgatg acctcgatgg
    10261 atgcaatggt gtggtcatcg ttcagcacaa agttggtctg cttggagcag gtgcccttgt
    10321 tcgggaagga aaattccttg ctcatggtct ttacgtcctc tctcttttac gtttttcggc
    10381 gatggcgcgc agctgcgctg cggcttcgtc cggtgcggta caggtaccga tggggtgggg
    10441 gtgcttgtgg ttgcggccat ggaagtccgt acctgcggtc gccacaaggc cgtactgctt
    10501 gcacagtgca aggcactcgg cgctgtcctc cgcactgttg ctggggtggt acacctctat
    10561 gccgtccact gcgccctctg ccgccagctc gcgcagcagg ggcatacttt tgtacaccgt
    10621 ggggtgggca aacaccaccg cgccgccgct ggctttagcg gtagccagca cctgccgcac
    10681 cggcagatac tccggcgagt gcagcacgat gccccggggg ttccacccga acagcttgtg
    10741 gtaggtctcg ccgtagatgc tgccatcagt caggcccagc agttccagcg cctgcatcag
    10801 cccgcttttg aacagcactc cgctggcctt ggtggtctcc cacgcaaggt cggtggtaaa
    10861 ctgcgggtac agctgctcca gctcctttgc gctctgcaaa gcgcaggcgt tgcggcgctc
    10921 cttcatgacg gcgcagtgct cccgcagcgc cgggcagtcc acgtccgggt agtagcacag
    10981 caggtgcacc cggtgctggc gctcaaagtc gtagccggtc agctccacgg cagggatcag
    11041 ctctaccccg tcctgcccgg tgtgggcgta ggcgtactgg gcgctgagca gggtgtcgtg
    11101 gtcggaaagg gcgatggcgt gcagcccggt gcgggcggcg atggacgcca gccgctcgat
    11161 gggcacagca ccgtccgagc aggtggaatg gatatgcagg tcacaggaca tagcgggtta
    11221 cttccttagt gcttatagaa attgatcagg cagccgtcag ccaggatctg gcgctcgtca
    11281 gtggtgagcg gggccatgta caactcgaat tccttgacgg tatcgcccaa aacgtaggcc
    11341 ttgatgctct gcaaatcgcc cttgagtgct tcccgcacat tggggatgag cacatagtcc
    11401 cccagaccaa agggggtggc acctgccagc tgcaggggca gcatgcccca gttgatcagg
    11461 ttggagcggt aacgcttggt ggcgtactcg gtaacgatat tggcaccggc acccagcaca
    11521 cgctggcagc tggcggcctg ctcacgggca gagccgtc
//
