LOCUS       c00047_gnlPro..        16506 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFPCCBAL_99.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 08:46:25
            Original ID  :: gnl|Prokka|HFPCCBAL_99
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 164143
            Orig. end    :: 180649
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16506
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[174143:178700]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16506
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16506
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="2"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             478..672
                     /locus_tag="ctg47_118"
                     /transl_table=11
                     /translation="MKKTELALLYMPYASADVARRHLNKCIRRNRELLEALEATGWAFW
                     IHWLTPLQVELIEKYLGEP"
     CDS             complement(676..2475)
                     /locus_tag="ctg47_119"
                     /transl_table=11
                     /translation="MDRFKELGIDTHGRTSGKMKTKCPWCHAQRTDKRDKSLSVNLDTK
                     LYLCHYCGAHGSAAIYAGKGRKLGDPLVKFPTATGSNSSCPPTEKPHGDPEQGALTQKQ
                     IEWCRDVRHIPPEVLVEAGVAFASISMPISGKEKGWEKRDCLCFNFFENGELVNTKFRD
                     SQKHFKLLQGARTIPYNIDAIRDTPECILVEGEFDALSYMAVGRTDVISVPNGANSQLD
                     WLDELSESHFEQKQVIYLSVDTDRKGRELCRELSRRLGVDRCRIVTYGEAYKDANELLV
                     AEGPDALLKALEDAPIPRLEGTFTAEDLREGLHQLFEEGYTSGVELGIPNLDEIMRLET
                     GRVLTVTGIPGHGKSDFVDEIVLRLCTRQDWRAGYFSPENTPIEYHHAKLAEKLLGHRF
                     RKDFSTEEEFARVVDYLSQRVWHILPDGDFTLGNVLSKARELVHRHGIRVFVIDPYNYI
                     NHQIPAGMTETGYIGSFMNSLARFARLNSCLVILVAHPRKMNKQYGTQKTEVPTMYDIN
                     GSANFFNMTDYGIVVDRQDEMGIVYIHVEKTRFRNFGTKGNAAFCYDVTNGRYSPCTPP
                     PEPGMQVQPWKGAKDLFSSEGWI"
     CDS             complement(2504..3808)
                     /locus_tag="ctg47_120"
                     /transl_table=11
                     /translation="MTTSNSANTKQSNNASQKRKPIHNGYFNHPTSSSSNIPMSILIRE
                     QGLEIYGLYWVMLEEAHAQLKCCVNIQTMGIIANIFHAQPEHLELLYHHYFRRPGKGYN
                     SHILYADFCEESAIRSYFPHPLLAYTDNELLRMIMQDGLKAYGLYWLVMEKLYQQPQHF
                     LAPQTASFIQNLYDVSDELMESVLYNYGLFYLDEKMNLHSKAIDDYREALDNMEDEKKR
                     NTKPHVNNSLKANGNAEDFNTREMKNTSNIQKNPSPIINKEINKKNSSSEESGKEKEEE
                     NGLKVTDLNAVTPDMRPNAWEENLQEAMNDTSWYEVVAIQSGIPRLMMEEKEWFFNYLR
                     EQIILRGNESSMNSLHEIKNYFANLTRQGSHVSSTTQVALKKFLKNRQEQQQCSPYETI
                     TNGIRTYDGHPIPAYAKPRPSAAHIWNPVTNEWTR"
     CDS             4141..4557
                     /locus_tag="ctg47_121"
                     /transl_table=11
                     /translation="MKLIFFHRRAEYNPCHSTRKPFSTMHVIVWEKPVGGVFVVGAAEI
                     VFIFCQCPCNGKAGSVCSLQAEIGVVPSHPVYQFFYLVCTAHRFSQCQQCAVILFRILA
                     DNSCPTGNRQATVILHRFFHTDFFVLKCSHFSSC"
     CDS             complement(4820..5251)
                     /locus_tag="ctg47_122"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTLINEIQ
                     AAMKRQNERIRDLKKAIGENNNVIRSDSWIKRLRKRFQW"
     CDS             complement(6238..6708)
                     /locus_tag="ctg47_123"
                     /transl_table=11
                     /translation="MTKSDLLPNKESTFTRLINKKMEITDLKQMTKEEVFNFIRQRLSF
                     SKELQEQFRHVNKDDLAKEHRRFEMSGNESKTGQCTIFNTAILNEFADLGIYDYTSYLF
                     LDFHNGTPTVYLKYFSENENLEYTFTGYTTTEIIFAILELTIFSGKPKRNRS"
     CDS             6840..8054
                     /locus_tag="ctg47_124"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRKVDMNTIYNYLNALESAFIIQRIPRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFAPLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             complement(8135..8389)
                     /locus_tag="ctg47_125"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             8812..9816
                     /locus_tag="ctg47_126"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSADHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPKTGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKYGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
     CDS             complement(10001..11161)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_127"
                     /sec_met_domain="OAD_beta (E-value: 7.6e-153, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(11163..11594)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_128"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.3e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(11619..12539)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_129"
                     /sec_met_domain="OAD_gamma (E-value: 7.4e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQNNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWIGLFDSGRKLLDQIVVPAGVLGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(12571..14124)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_130"
                     /sec_met_domain="CT_Btheta (E-value: 2.2e-289, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(14153..14557)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_131"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.4e-23, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(14733..15731)
                     /locus_tag="ctg47_132"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPVARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNDMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMKKTYALQYPGVLAVWKALEDARQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRVNWNWLNKLLVKFYV"
     CDS             15882..16424
                     /locus_tag="ctg47_133"
                     /transl_table=11
                     /translation="MLEEILAYNKQFVENKGYESYITNKYPDKKIAILSCMDTRLTALL
                     PAALGIKNGDVKMIKNAGGVISHPFGSVIRSLLVAIFELGVEEIMVIAHSDCGACHMHS
                     EVMLEKMKARGINPDYIDMMRFCGVDFHSWLDGFEDTEKSVRGTVDFIVRHPLIPSDVT
                     VYGFIIDSTTGELTRIV"
ORIGIN
        1 gggtaaatgt gcccaatcct tcgagcttca ctgtccggct gttgagcaac tgctcgcgca
       61 tcactgccat caggtttcgg atcacgttgt gcacgtcacc ggccgtcagt gatgaccgtt
      121 cggcaatcgt ttcgccaatc atttgcgtat ccactacgtt tcccatttta atcaggcagg
      181 gatgccattt cttctttttg tccttcgatg cgatattgga ctgaaccgct ttgtaaatca
      241 acatactgat ttcctccttt ttaagtgaat aaataagatt ttattgagtc agtaaacgaa
      301 cgttttctgt ctcttttaca gtagcaaaga taccccaacc ggcaggggag gaaacatgaa
      361 acggtatctg ccggtaagtg aaggcaaacg cttgaatatc tgtgtatttg cttgcatttc
      421 tacgcaaaaa acagtatctt tacatgacgt aaataataaa ttaaaagaag aaaatctatg
      481 aagaaaacgg aattggcatt actctatatg ccgtatgcaa gtgccgatgt ggcaagaaga
      541 catttaaata aatgcatccg ccgaaaccgg gagctgctgg aggctctcga agctaccggc
      601 tgggcgtttt ggatacattg gctcacaccg ttgcaggtgg agctgattga gaagtatttg
      661 ggagagcctt aatccctaaa tccatccctc tgacgagaat aagtctttgg ctcccttcca
      721 cggttgcacc tgcatgcccg gttcgggtgg cggcgtacaa ggggaatatc ttccgttggt
      781 cacatcgtag cagaacgctg cgtttccctt tgttccgaaa ttacggaaac gggttttctc
      841 gacgtgtata tacacgatcc ccatttcatc ctgacggtct accactattc cgtagtccgt
      901 catgttgaaa aagttggccg agccgttgat gtcatacatg gtgggaactt ccgttttctg
      961 cgtgccgtat tgcttgttca tctttctcgg atgcgccacc agaatgacga ggcaggagtt
     1021 gagccgggca aaacgtgcca gactattcat gaatgaaccg atataccctg tctccgtcat
     1081 gcctgccggg atctgatggt tgatgtaatt gtacgggtcg atgacaaaca cacggatgcc
     1141 gtgacggtgt accagttcgc gtgccttcga caagacgttg cccagtgtga aatccccgtc
     1201 cggaagaatg tgccagacgc gttgcgaaag ataatccact acgcgggcga attcctcctc
     1261 cgtagagaaa tctttgcgga aacggtgtcc cagcagtttt tccgccagtt tggcatgatg
     1321 atactcgatt ggcgtgttct ccgggctgaa atatcccgct cgccaatctt ggcgggtgca
     1381 gagccggagc actatctcat ccacaaagtc cgatttgcca tgtccgggaa taccggtgac
     1441 ggtgagcacc cgccccgttt ccagcctcat gatttcgtcc agattcggta ttcccaattc
     1501 cacgcccgaa gtatacccct cttcaaacag ttggtgcaac ccctcccgta agtcttctgc
     1561 cgtaaacgta ccttccaggc gggggatggg cgcgtcttcc agtgccttca gtagtgcgtc
     1621 cgggccttcc gccacgagca gttcgttggc gtccttgtat gcttcgccgt aggtgacgat
     1681 acggcagcgg tctaccccca gccgtcggga gagttcccgg cacagttccc gtcccttgcg
     1741 gtcggtgtcc accgacagat aaatcacttg tttctgctcg aaatgagatt ccgacaattc
     1801 gtccagccag tccagttgac tgttggcacc gttcggcacg gaaatgacat ccgtccggcc
     1861 gacagccatg taggagaggg catcaaattc cccttccacg aggatgcact ccggcgtgtc
     1921 gcggatggcg tcgatgttgt aagggatggt gcgcgctcct tgcagcaatt tgaagtgctt
     1981 ttgtgagtcg cggaactttg tgttcaccaa ttccccgttt tcgaaaaagt tgaagcagag
     2041 acagtccctc ttttcccagc ctttctcctt tccggatata ggcatcgaga tggaggcgaa
     2101 agccacgcca gcttccacca atacttccgg cggaatgtgg cggacgtcac gacaccattc
     2161 aatttgcttc tgtgtgagtg ccccttgctc tgggtcgccg tgcggctttt cagtgggcgg
     2221 acaactggag ttgctacctg ttgccgttgg aaatttgacc aacggatcac ccagctttct
     2281 gccttttccg gcatatatgg ctgccgaacc gtgtgcgccg cagtagtggc acaaatacag
     2341 tttggtatcg aggttgacac ttagtgattt atcacgctta tccgtccgtt gggcatgaca
     2401 ccagggacat tttgttttca ttttgccgct tgtgcgaccg tgggtatcaa tacccagttc
     2461 tttgaatcta tccatattta gtaaatgatt gagagataat atgctatcgt gtccattcgt
     2521 tcgtcaccgg attccagata tgtgccgccg aaggtcgcgg cttggcataa gcggggatgg
     2581 gatgcccgtc gtaggtacgt attccgttgg tgatggtttc gtagggcgaa cattgctgtt
     2641 gctcttgccg gtttttgaga aacttcttca gtgccacctg cgttgtggat gacacatggc
     2701 ttccctgccg ggtgagattg gcgaaatagt tttttatttc gtgcaggctg ttcatcgagc
     2761 tttcattccc ccgtaagatg atttgctccc gtaaatagtt gaagaaccat tctttttctt
     2821 ccatcatcag ccgggggatg cccgactgaa tggctacgac ttcataccag gatgtgtcgt
     2881 tcattgcctc ctgtagattt tcttcccatg cgttggggcg catatcgggt gtcacagcgt
     2941 tcaagtccgt caccttcaaa ccattttctt cttctttttc ttttccgctt tcttcagaag
     3001 aagaattttt tttgtttatt tctttattta taatggggga tggatttttc tgtatatttg
     3061 acgtattttt catttcccga gtgttaaaat cctctgcatt tccgttggct ttcagagagt
     3121 tattgacgtg cggtttcgtg ttgcgctttt tttcatcttc catgttgtca agtgcttccc
     3181 tataatcgtc tattgcttta gaatggaggt tcattttctc atccagataa aagagtccgt
     3241 aattgtataa tacactttcc atcagttcgt cgctcacatc ataaaggttc tggatgaagg
     3301 aagcagtttg cggtgccaga aaatgttgtg gctgttgata gagcttttcc atcacaagcc
     3361 aatatagtcc gtaggctttc agtccgtctt gcataatcat ccgcagcagt tcgttgtcgg
     3421 tgtatgccag tagggggtgc gggaaataac ttctgatggc agattcttcg caaaagtcgg
     3481 catagagtat atgcgagttg tatcctttgc cgggacgccg gaaataatgg tggtagagga
     3541 gctcaagatg ttcgggttgg gcatggaata tattggcgat gattcccatt gtctggatat
     3601 tgacgcagca tttaagctgt gcatgagctt cttcgagcat cacccagtat agtccgtata
     3661 tttccagtcc ttgttcccgt atcaaaatac tcatgggtat attgctggaa gaagaagtgg
     3721 gatgattgaa gtaaccgtta tgaatcggtt ttctcttttg tgatgcgttg ttcgattgtt
     3781 tggtatttgc tgaattagat gttgtcataa taaaatatat tagtttctgt tttaaattct
     3841 atttttctga aaatacagat acgaagaatc cggccacttc tttggaaagc agcaaatatc
     3901 gtactcattc ttcatgatgg aatcggagta ttctcttcgt gtatgtaatc tgtaatatag
     3961 ggaattttcg gagcagggga gatttaattc cgaagttctg aaaaagcaat gcaggaaaaa
     4021 cagataactg cctctgtcaa aaaacaagga agcagcattg acatgatttt ttctcttact
     4081 tgcggttgca aagtaactac tttatttcgt atatgtccta caactttcct tatttaatcc
     4141 atgaaattaa ttttttttca cagaagagcc gaatacaatc cctgccactc gacacgtaag
     4201 ccattttcta caatgcacgt catagtatgg gagaaacctg ttggaggggt tttcgtagta
     4261 ggggcggccg aaatagtgtt catattctgt cagtgtccct gtaatggaaa ggcaggttcc
     4321 gtctgttcgt tgcaggcaga aatcggcgtt gtcccatctc atccggtcta tcagttcttc
     4381 tacttggtat gcacggcgca tagattctcc cagtgtcaac agtgtgccgt aattctcttc
     4441 cgcatcttgg cggataatag ctgcccgacg ggaaaccgtc aggcaactgt cattcttcat
     4501 cgtttttttc atacagattt ctttgtgctg aaatgctcac atttcagttc ttgttagtgg
     4561 tgtaaatgta gtgaatttac ttgactttac aaaggataaa attacttata taatggatga
     4621 ttagttaaat aaatggaata aaatattttg tatttttcat tgtttgaata taggctttaa
     4681 agagcttatg gaggagttta aagaaagctg tggagggaat gggaataggc tgcaaagggc
     4741 aaaggacggc cctctttatc ctctgtggtg aaaaccgtgc aataatgtcc cacatggtaa
     4801 ttggtacact gataattatt caccattgaa accttttgcg cagccttttt atccaactgt
     4861 cactacgtat aacgttgtta ttctctccaa tcgctttttt caaatcccgg atccgttcat
     4921 tttgtctctt cattgctgcc tgtatttcgt ttatcaacgt atttatttcc ttctgcagct
     4981 gaatttcctt ttctttcaat tgaataatgt gggcgtattt ctcgcagacc attgttttat
     5041 ctatgcacag ttgttccagc gtatcaatat attctgctgt aatgccggct ttacttcggc
     5101 gaaagagttc cagaatacat tcttcgtcaa cattcggaac attgtctatg tataacatag
     5161 ggaattgtcc catttccacc caaagcagga tcgcttcttt ttcgatgtga tacttaatca
     5221 ctgctttttc tacactaatc cattttggca tatcgctttt gttttaatgt gttataaaaa
     5281 aggagtaaat aacgtattgt ccggagaggt gcaacgaaca cccacgattt ttatgatttc
     5341 ggtcggctgg ggaattggtt ggggtataag gattgttgaa accgaccgga tacaataaaa
     5401 gcgtgagtgc tgttgtacca ttatctaaac ttaaggctta gcaacaccct tcaccagata
     5461 atgataaaca acagacaccc acgccaaacg tttatatata acaaatctct aatcgatatg
     5521 ttgatatacg actatctacg tggagtatct gttgtatcat ctctcggtgt gaaaaaactg
     5581 ctaattttta agtttgagag acaatacgtt atttactcca ttaaggaata aaaaaacgct
     5641 tttgcctgtt tcatcacgct gatgggcaga aagcgtgtga caaagatata tgtttttttc
     5701 ggaataggat ggaaaagagg aaataaatgc aggaaatatg gtatgagaat agagagtatt
     5761 gtccggagag gtgcaacgaa cacccacgat ttttatgatt tcggtcgggt ggggtattgg
     5821 ttggggtata aggattgttg aaaccgactg gatacaataa aagcgtgagt gctgttgtac
     5881 cattatctaa atcgaggtct tagcataccg tgcaccagat aatgataaac aacagacacc
     5941 cacgccaaac gttttatata acaaatctct aatcgatatg ttgatatacg atcatctacg
     6001 tggagtatct gttgtatcat ttcccggtgc atgaaatttg ctaagtttcg atttgggaaa
     6061 caatacgtta tttactccat gaaggaataa aaaccgcctt cgcctgtttc atcacgctga
     6121 tgggcagaaa gcgtgtgaca aagatatatg ttttttcgga ataggatgga aaagaggaaa
     6181 taaatgaaag ccataaaagt cttttgacct cgcattgtct ttccgtgcaa ttctttttta
     6241 gctgcgattt cttttgggtt ttccggagaa gatagtcagt tcaagaattg caaagatgat
     6301 ttccgttgtg gtatatccgg taaatgtata ttccaaattt tcattttcgg agaagtattt
     6361 gagataaacg gttggagtgc cattgtggaa gtcgagaaaa agataagaag tataatcata
     6421 gatgccaaga tcggcaaact cgttcagaat cgctgtgttg aaaatcgtgc attggcctgt
     6481 ctttgattca tttccggaca tttcgaatct gcgatgttct tttgcgagat cgtctttatt
     6541 cacatgtctg aattgttctt gcagctcttt actgaaagaa aggcgttgtc tgatgaaatt
     6601 aaaaacttct tcctttgtca tttgttttaa atcggttatt tccatttttt tattaattag
     6661 tcgggtaaag gtactttctt tatttggtaa taaatcggat ttagtcatat ttcttttatt
     6721 tatttttcgg cttgtaaccc taaaagaatc tgaatttatg gatttattta gggttataac
     6781 cctaaaaact ttccgaaaat agtatatctt tgtgcttata accctaaaaa cttttgaata
     6841 tgattaatcg tgaacagtat atggaacaaa ttgttccttt tatagataag ccgtttgtaa
     6901 aagtgataac gggtattcgt cgcagtggaa agtcggtagt gctgcgtctg attcgtgacg
     6961 aactgttgag gagaggagtt cgtgaagaac gtatcatcta tctgaatttt gaaagttttc
     7021 agtggataga tctgaaagag gcgaaggctt tgtatgctta tattcgggga caggcgggag
     7081 atgcgggtaa atattatatt ctcttggatg aaattcagga agtggacggt tgggaaaaag
     7141 tggtcaactc acttctggta gatttggata cggatattta tgtgaccggc tccaactcac
     7201 gtatgttatc gtccgaactg gcaacttatt taacgggacg gtatgtcgct ttccatgtca
     7261 tgaccttgtc ttttagagaa tatctgactt tccatgactt gcaggccaat gatccgacac
     7321 tcaaccggaa ggaggaattt cagaaatatc tccgtatggg aggattccca gccatacata
     7381 ctgccgatta tggatatgag gctatctata aaattgttta cgacatctat tcttctgtca
     7441 ttcttcgtga cacggtgcag cgtcacaata tccggaatgt ggaactgctc gaacgggtag
     7501 tgaagtttgt tttcgataat ataggcaata agctgaacgc taaaaatata gccgattact
     7561 tcaaaagtca gcaacggaag gtggatatga ataccatcta taattatctg aatgcattgg
     7621 aaagtgcttt tatcattcaa cgtattcccc ggtatgatat taaaggaaag gaaattctgc
     7681 agacgaatga gaagtatttt gtaagcgacc tttctttgat ttattccgtg atgggctatc
     7741 gtgaccggtt gattgcaggt atgttggaga atctggtctg tctggagttg aaaagaaggg
     7801 gttatgaagt gtatgtaggc aaacaggatg ataaagaagt ggattttgta gccatccgtc
     7861 gggaagaaaa gatttatgtg caagtaacgt atcagttagc ttcacaggca actgttgaga
     7921 gggagtttgc tcctttgctc gccattaacg accattatcc taaatatgta gttagcatgg
     7981 acagcttgtg gcaggataat gtggagggtg tcaggcatcg tcatatagcc gatttcttgt
     8041 tggatgatgc ttgacgttaa ggaatataga aaacgaaaaa gaggagattc tcgcagagaa
     8101 tttcctcttt tttcatcttt cacgaaagat cgaattattt cttcttacgg tcaccgtaac
     8161 ggctcatgaa cttgtcaaca cgacctgcag tatctaccaa tgtagattta cctgtataga
     8221 acgggtgaga agtgtttgag atttcaatct tcagcaacgg ataagtttca ccttcgaatt
     8281 cgatggtttc tttagttgct acagttgatc tagacaaaaa catgtcacca tttgacatat
     8341 ctttaaatac taccggacgg tatgattctg gatgaaggcc ttttttcatt tcagtatctg
     8401 tttttttaat ttatattctg ttactatttt ggtaagaaat agtgtaatgg tcattttcag
     8461 agcgcaaaga taatgctttt ctgtgaaata gaaaaaggtt ttctaaaatt tctgatttct
     8521 aatttatgat ttctgatttg ctatgcagat tttgatgatt aaatgaatga aaaatgaggt
     8581 ataaataagg agatataaat ccgaaggcat aaatcagaat tcagaaatca taaatcccaa
     8641 agtttgcaag gtggacatta caatctaatg tcacactcgt attcctgcta aattttgctg
     8701 tctgatttaa acctttttct actatatttt tctttccgat gttcgttatt cgatggataa
     8761 tgcttacttt tgcgtagaat ttttattcac taacaataaa ctttaaacaa aatggtaaat
     8821 tacaaagatt taggattggt aaacacaaga gaaatgtttg ctaaggctat caaaggtgga
     8881 tatgctatcc cagcattcaa cttcaacaat atggaacaaa tgcaggctat catcaaggct
     8941 gctgttgaaa ctaaatctcc tgtgattctt caggtttcta aaggtgctcg tcagtatgct
     9001 aacgctactt tgttgcgtta catggcacag ggtgctgtag aatatgctaa agaattaggc
     9061 tgcgcacatc cggaaatcgt tcttcatctt gaccacggag atacattcga aacttgcaaa
     9121 tcttgtatcg attcaggttt ctcttcagtg atgattgacg gttctcatct tccttacgaa
     9181 gaaaacgtag cattgactaa gaaagttgtt gaatacgctc accagtttga cgtaactgta
     9241 gaaggtgaac ttggcgtatt ggctggtgta gaagatgaag tttctgctga ccaccacaca
     9301 tatactgacc ctgaagaagt aatcgacttc gctactcgca ctggttgcga ctctttggct
     9361 atctcaatcg gtacttctca cggtgcttac aagtttactc cggaacaatg ccacatcgac
     9421 ccgaagactg gccgtatggt tcctcctcca ttggctttcg aagtattgga cgctgtaatg
     9481 gaaaaacttc cgggattccc tatcgttctt cacggatcat cttcagttcc ggaagaagaa
     9541 gtggaaacta tcaacaaata tggtggtgca ctgaaagctg ctatcggcat tccggaagaa
     9601 gaattgcgta aagctgctaa gtctgctgtt tgcaaaatca acatcgactc tgactcacgt
     9661 ctggctatga ctgctgctat ccgtaagact ttcgctgaaa aaccagctga attcgaccca
     9721 cgtaagtatc ttggtccggc tcgtgacaac atggaaaaac tgtacaagca caaaatcatc
     9781 aacgtgctcg gttctgacaa caaattggca cagtaataat ctccggatta ttccataaat
     9841 aaaagaaaga ggctgctccg gtttgaacac tggtagcagc cttttttatg acgtttaatc
     9901 gtttcagaac ggagggaaga taacactatg gctgtaataa agaacacccg tgtcacaact
     9961 gaatgtaaca cgggtgttct tatctattat ataatgtttc ttacatcaag aatccaagca
    10021 ggataccggc agcaacagct gaaccgatca ctccggcaac gttcggaccc atagcgtgca
    10081 tcagcaaata gttggtcgaa tcgtattcca aaccaatcac ttgcgagata cgtgcagagt
    10141 cgggaacagc agaaacacct gcattaccga tcaacggatt gatcttatta cccttcttca
    10201 ggaagatatt gaagatctta acgaagatga caccagatgc cgttgcaata acaaatgaca
    10261 atgcaccgag ggcaaagatc ttgatagagt caagcgtcag gaattcggat gcttgtgtag
    10321 aagcacctac tgtcagaccc aacaggatag tgattgtatc aatcaacgga ccactggcag
    10381 tattagccaa acggcgggtt acaccacttt ctttcaacag gttaccgaag aacagcatac
    10441 ccagcaaagg cagaccggaa ggaaccagga aacaagtcag caacaaaccg atgatcggga
    10501 aaatcacctt ctccgtgtga gaaacggcac gcggcggttt catgcggatg acacgttcgt
    10561 tcttggtggt gagcagacgc atgataggcg gctgtatcac cggaaccaac gccatatagg
    10621 agtaggcgga caccgcaatg gctcccatca ggttaggtgc tagcttggaa gaaaggaaga
    10681 tggccgtcgg gccgtctgct ccaccaatga taccgatagc accggcttgc attgggtcga
    10741 aacccatttc caatgcgatc atatatgcac cgaagatacc gaactgtgca gctgcaccaa
    10801 tcagcatcaa ttttggatta gagataagtg ccgagaagtc cgtcatggca ccgataccca
    10861 aaaagatgag tggcggatac cagccggagg tcactccctg atacaatata ttcaatacag
    10921 aaccttcttc ataaataccg actttcagcc cggcatccat attaaaaggt atattaccaa
    10981 tcaatatacc aaaaccgata ggaatcagca gcattggttc gaactctttg gctattgcca
    11041 aatagatgaa taccaagcca acgagaatca tgactacatg ccctaccgta gcattggcaa
    11101 agcctgtgta tgtccagaag tcggccaggt tatttcctaa aaagtttata aagtctccca
    11161 tattattcaa taattacgag gtcattacct tcaagaacag agtctccctt gttgacgttg
    11221 atggcagtaa tcttaccgtc cttatccgca ttgatattgt tttccatctt catggcttcc
    11281 aatatgataa tggtctgtcc tttctttaca gtatcgccta cattcacttt gatgtcgagg
    11341 atcacacccg gcagcggaga ttttactcct gattttccgg tagacggagc ggtcggtttc
    11401 actacttgag taggagcagc aggagcatta ggcatcgggc gtactgtcac gggtttcgca
    11461 acaggcttcg gctgtttctc catttctact ttatagtgtg taccgttcac ttctacatga
    11521 gcgatattat cttcaatatc tccgatggtt actttatatg agttaccgtt gattttatat
    11581 ttatattctt tcatcgtttt aactttttaa aaggtgactt actttctggg aggagtttca
    11641 cgcaaagtgt aaatcttcga actccatggt gagtaactgc gttttacgcg agtgatggtc
    11701 agtaccgttt cttctacgtc gtgcacttca tcctgcattt cgtgcaatgc catagaaatc
    11761 gcagcgtaaa cttcgcccgg agcctgtgac agttccttag cttcatgctt gtcaatgcct
    11821 ttagatttca tagcattgcg cttgctcaaa tttacagcta cttttcctac aatcttgaag
    11881 gcaataaaga gaagaatcaa tccgcagaat actacgctca tggcagaaat ggacattcca
    11941 acgccatcag catcgtgttc ttcaaacttt tccatcttgg aattgctgtc aagagtcttg
    12001 ttgttggtgc tcggagtcac gtatttgtca ccgcttccac tttttacttc ccattcagct
    12061 gctccgtcgc tgacacgagc gtatgactgg ttgggaccaa gaacacctgc gggcactaca
    12121 atctggtcga gcagctttct accggagtca aacagaccga tccagttggc cgtttccgga
    12181 ttcagcttga agctggtgtg gaaagtaccg cggttaggtt cgccatctgc ccagaatagt
    12241 gcatgttgac gtggcttcac taatgtaagt atatcacctt tcgggataaa gtaagtaact
    12301 gtatcgcccg gttggctgct tactttcaac aagcaagctg ccaggtcggc gctaccgaat
    12361 gatttattga atatttcaat ccatgcgctg tgcaatccgt agtcatcttg aaaattattc
    12421 tgattgtcta tcaggatttc gtttagtacc agcttgttgt tcgacttttg ctctccacaa
    12481 gaagtcagcc caatcagcaa cagcaaagaa aggaatattc cgattttggt tttgttcata
    12541 atcgttcttg ttttaatgtg aaaagtaaga ttacaacgga atattaccat gcttcttagc
    12601 cggattactc aatttcttag tctgcaactg ctgcaaagca cggattacgc ggaaacgtgt
    12661 gttgcgtggt tcaatcacat cgtcgatgta gccgtatttg gctgcattgt aaggattggc
    12721 aaacagtttc gtgtattctg cttctttttc agcaaggaat tgagcgggat tttcctgatc
    12781 tttggcttcg cgtgcgtaca atacttctac tgctcctgct ccacccatta ctgcgatttc
    12841 ggcagtaggc catgcgtagt tcatgtcacc gcgaagttgc ttacagctca ttacgatgtg
    12901 agaaccaccg taagatttac gcaatgtgat agtaacctta ggcacagtag cttcaccgta
    12961 agcatacaac agtttagcac catgaaggat aacgccattg tattcctgac ctgttcccgg
    13021 aaggaatccc ggtacgtcta ccaacgatac gataggaata ttgaatgcat cgcagaaacg
    13081 aacaaaacgt gcacccttac gagatgcgtt gctgtcgagc acaccagcca gatacttagg
    13141 ctgattagca acgataccta ccgattgtcc gttgaagcgg gcgaaaccga tgatgatatt
    13201 ctttgcataa tctttctgga tttcaaggaa ttcaccgttg tccacaatag cgccgatcac
    13261 ttcgtacatg tcatacggtt tagtagggct gtcggggata atatcattca aagaatcttc
    13321 caaacggtcg attgggtctg tacaatctac ataaggagct tcttcaaggt tgttttgagg
    13381 aatataactc aacagtttac gaatcagttc gaaaccttct tcttctgttt tagcggtgaa
    13441 atgagtcaca cctgatttag tggagtgaac gcttgcgcca ccgaggtttt cctggctaac
    13501 gtcttcacct gttacggtct tcacaacttt tggtccggta aggaacatat aagaagtacc
    13561 ttccatcatt agcgtgaagt cggtcagagc cggagaataa acagcaccgc cggcacaagg
    13621 accgaagata cctgaaatct gtgggataac accggaagca aggatattgc gttggaagat
    13681 ttctgcataa cctgccaaag cgttgatacc ttcctgaata cgtgcaccac ccgagtcgtt
    13741 gataccgata cagggagcgc ccatcttcat ggcttgatcc atgattttac aaattttcaa
    13801 tgacatcgtt tctgacagtg aaccggcaga aacagtgaag tcctgtgcga acacatatac
    13861 cagacgtcct tcgatcgtac cgcagccggt tactacaccg tctcccgggt aatgtttttt
    13921 ctccatgccg aagttcgtgc atctgtgctc aacgaacatg tccatttctt cgaagctacc
    13981 ctcgtcaagc agcatagcca gacgctcgcg tgctgtgtat ttcccttttt cgtgttgctt
    14041 cgcaattgct ttttcaccgc ctccgatacg tgctacggca cggcgttcaa taagctcttt
    14101 aattttttca agttgattac tcatgagttc ttgttagttt tagagtttat gattaatgtt
    14161 cgcagagttc tgttaacaca cccaaagttg atttcgggtg aaggaaagca atattcaaac
    14221 cttcggcacc cttgcgggga gctttgtcga taaggcggat ttctttgctt tctgcttctg
    14281 ccaaagcatt ggctacgcca tcttctacag caaaggctac atggtgaaca cctgcacctt
    14341 tgttttcaat gaatttggca atagtactct ccgggcaagt cggctccaac agttcaattt
    14401 tggtttcgcc tacttttaaa aaagcagttc ttactttctg atcttccact gtttcaatgt
    14461 tgtaacactt cagacctaat acattttcgt agtaaggaag ggcttcttcg atgcttttta
    14521 cagcaatgcc cagatgttca atgtgtgaaa tcttcataac tatacttttt ttatttggtt
    14581 ttaatcatgt gcttatatgg cataaaacag cacaaagaaa ggcatttctt acctaataaa
    14641 gaaatatttc tgcatttaat tattggatta ttaaacagaa aaaatggtag ggaaggagca
    14701 tgaagagtcg ttttgcaatc ttgagattac atttagacat aaaatttgac taagagtttg
    14761 ttcagccaat tccaattgac acggaaccag cggcgggtac tgctttgctt tcctccgaat
    14821 cggagaacga aatcacgata accgtgtttg cggaacggaa gtcctacatc cataaattcc
    14881 atgtgacgga atccccgttg gcgggcgtct tccaatgcct tccaaacggc cagcactccc
    14941 ggatactgaa gtgcgtatgt ctttttcatt cctccggaaa accaaaggta cgcgtcatct
    15001 cccgagtaga tacagacgga accgccaatg attttctctt tgtattttac tacgaatatt
    15061 tttgcctgtt gtcctttgat tagcatatcg ttcatgtgac ggaaaaagtc gttggcaggg
    15121 aaatatctgc gtatgcggga ggaataaacc ttatgcagca tccgtgagaa atcgtgtatt
    15181 tcttccacgg tatgtgcctc ctctactttg gctccattct tgagtccttt ttttatctga
    15241 cggatgcgtg acgggctgaa ccggtcttcc gtctttttca tactgtgcag cgaattgcgt
    15301 acccgcagcc agttgacagg gaaataatca ttggcacgga aaacccggta accgaacatc
    15361 gaattattga gattccggaa ttcgatcagg acacagctac gcgatgcttc ttgtgtgaga
    15421 tgttcgagca tatcgccaaa gacttcttct gccttttctt tgttggtcga aagcgactca
    15481 tccagaaatt caccttcgct atatactacg caatgtttca ctaaagagga gggaagccac
    15541 tttttcgctt tgcggatggc agcaagcagg cgtgccacag gcctgccgtc ttctgttgcc
    15601 actattaata aaggagtata ccccggagtc gcttcataaa tctgaaataa ctctttggaa
    15661 tggaaggcgt tttttcccgg cagttcagga atgtccttcc catgataata tgtggttagt
    15721 ttaagtggca tctaggtaca aatttacact ttttattctt tattcaacaa caaaacagag
    15781 attttgttgg aactgcttga tatatatagt tgtaaaaaat gcacctttat atattttttc
    15841 tatctttgcg taatcgaaca gaacttttaa aaagcggaac tatgttagaa gaaattttag
    15901 cttacaacaa gcaatttgtt gagaataagg gatacgaatc gtatattacc aataaatatc
    15961 ccgataagaa aatagctatt ctttcctgta tggacacccg actgactgct ttgcttccag
    16021 ccgcattagg aattaagaat ggcgatgtaa aaatgataaa aaatgcaggt ggcgttattt
    16081 cccatccttt cggtagcgtg atacgtagtt tgctcgttgc tatttttgag ttgggggtag
    16141 aggagataat ggtgattgct cattctgact gtggagcttg ccacatgcac agtgaagtaa
    16201 tgctcgaaaa aatgaaagca cgcgggatca atccggatta tattgacatg atgcgtttct
    16261 gcggagttga ctttcattcg tggctggatg gcttcgaaga tacggaaaag tcggtgagag
    16321 gaacagttga ttttattgta cgccatcctt tgatcccttc agatgtgaca gtctacgggt
    16381 ttattattga ttctacgacc ggggaattaa ctcggattgt atagataatt cgggatattc
    16441 ctaaaataat aaaatttaag gcaactaatt cattgcgagt tagttgcctt ttttgtatct
    16501 ttaagc
//
