LOCUS       gnlProkkaFMJMGOMK_135  13652 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FMJMGOMK_135.
ACCESSION   gnlProkkaFMJMGOMK_135
VERSION     gnlProkkaFMJMGOMK_135
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 07:32:58
            Original ID  :: gnl|Prokka|FMJMGOMK_135
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 195696
            Orig. end    :: 209348
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13652
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13652
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13652
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2151..3161
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg71_152"
                     /sec_met_domain="PF04055 (E-value: 1.6e-17, bitscore: 57.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDDMTNLSLKH
                     RELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATLCVSSQVGC
                     KMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNLDEVLKALE
                     LLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAELMPAEKAF
                     SITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRVNLIRFHAI
                     PGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEKNNES"
     CDS             3180..4220
                     /locus_tag="ctg71_153"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4225..5319
                     /locus_tag="ctg71_154"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5329..6570
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.2; E-value:
                     2.3e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg71_155"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6557..7084
                     /locus_tag="ctg71_156"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7090..7863
                     /locus_tag="ctg71_157"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGYELIDDFIEK
                     SESDSPLCKKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7870..8265
                     /locus_tag="ctg71_158"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg71_159"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMAIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg71_160"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-10, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVV"
     CDS             complement(10370..10654)
                     /locus_tag="ctg71_161"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10691..11758)
                     /locus_tag="ctg71_162"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPAVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKELNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKMPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11832..13343)
                     /locus_tag="ctg71_163"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 cgctcatttc cagttgaatg gcttttcaca ggcggatgcc aagtcgttct caaagcaata
       61 tttgtctact tactccaagg ctttgtctgc acagcaggaa gatattcttg cttcgtgggt
      121 gctggctgaa caaccgcgct gtttaagtgt attgctcaac gagctggttt cgttcggtca
      181 gtacgatgct ctcaatgaat atatgcgtgg atattgccgg ctcaatgagg ttgggcaatt
      241 ctatgacagt gtgctacggc gtttgtcggc tgattatggt tccgaagaga ttggaagaac
      301 gcttctgatg ctttcactta ctttagaagg atttaccgaa gatgaagtga agagcatggc
      361 agacattaat cagatacttt ggtcgcagtt gagagtggaa atgagcagct ggctcaccaa
      421 caaaggagga cgatattgca ttggtgatac acaaatggta gaggcgatcg aacgctattt
      481 cgctcaagat gacgaatgta tagatgatag tcgccatgaa attatttccg ctctgctgga
      541 tgaggaagaa atcctttccc atccgttgac ttttgccgat tataactatc gcatgaaaca
      601 gttctgctac catgattcgt atcgctataa agtggagatt acctatcaat gctataagat
      661 gcaagaatgg gatatattga aggattggat ttgtgatgtg gagattttcg agattctgta
      721 tcgcacgaat cgttttctgt tggaagatag ctggaaggcg atcatgaacg acaatcctga
      781 agttacgcct gaagtctatg ccgaattgga ctttgatgag atcgattctt ttttaattcc
      841 tgtcattgct aatgatatgg ctactttctt gagcagttct ttccatctga cgaaggcggc
      901 agctgctgtg agtgagaaga gtatggaagg tgctgccatg ccactcattg ccaagtcggt
      961 attgaagatg aatgagggat gtcggtatgc ccgtaatgaa gaatacgaaa cggcatgcga
     1021 ctgtttcctg aaagcattgg tgatgcagga aaacattgtg ccgactccgg aactggagat
     1081 tgccaatacc tgccgaaatc tagctctggc atattactac aatgagcaat acaatgaagc
     1141 ggcgatctat ttgaataggg cgcttgatta tcatgcggct tctgctgacg agaagagtca
     1201 ggcagaagtc attgaacttt ccgaatatct ggcttattgt gattactata aggatgagga
     1261 agagagtgct gccgagaaat tccggaaagt agctgaaatg cacgagtcat tgaatggcag
     1321 actgtccggt ggagtggcta aatgtttgcg tatgcagggt aaatgtcttt attatatcaa
     1381 acgatacgat gaagcatgga tgctgatgaa tcaggcgttg gacattgcta tacagataga
     1441 tagcaaaaaa cagatcgtcg cttgtcataa acagttgtat tatctgtgca gggaattcaa
     1501 acggatgatg aatgaacgtg gcgatgagca ggcgtctact ttattcttcc gtgagtctct
     1561 tctgcatgaa atgtatttca gcgaaaaacc gcgtctggcg gaactgactg tccgatatga
     1621 ggcattgaga tgtgatatta tgcagcagta ttacatgaat aaagactatg ataacgtgat
     1681 tcgtattgcg acgtctttgg atattcacga tgatgctgac cctaatgctt cctgtctggt
     1741 atattattac aaagcacagg cttatgtgaa gttggagaat tatccaatgg cgaaagaggc
     1801 tttcttcaga gaacttgaac tgcgaaagaa gtatttggga tgggaggaag aagatacgat
     1861 tctggcttgt cagaacttag gggttttgca cagcttttgt aatgaacggg aagaggcgct
     1921 ggcttgtttc cgtgaggcgt acggttatga agtgaaaaag aatggcgagg attctgaaat
     1981 ggcgcaaaag ctacttcaat atatcagcgt ggttgaatca taacggaggc atacttccct
     2041 tttttgttaa cttttacatt cctgctatac ggaaatcgac tttatttcct tacatttgca
     2101 gatataaact atcaacagaa agaagaatgt ctaaatatcc ccttttagga atgactcttg
     2161 tagagcttca atcattgaca aaaagactgg gtatgcccgg ctttgctgcc aaacagattg
     2221 catcctggct ttacgaaaag aaggtagcct cgattgatga tatgactaat ttgtcattga
     2281 aacaccggga gttgctcaag cagaactatg aggtgggagc ggaagctccg gtagatgaaa
     2341 tgcgctctgt agatggtacg gtgaagtatc tttataaagt gggtgagaac cattttgtag
     2401 agtcggttta tataccggat gatgaccggg caacgttgtg cgtgtcgtca caagtgggct
     2461 gcaagatgaa ctgtaagttc tgtatgaccg gcaaacaggg gtataccgct aacctgaccg
     2521 ccagccagat catgaaccag attcattcgc tgccggaacg ggataaactg actaatgtcg
     2581 taatgatggg aatgggcgag ccgctcgata acctggatga ggtattgaag gcattggaac
     2641 tactgaccgc tacctacggt tacgcatgga gtccgaagcg tatcacgctt tctacagtcg
     2701 ggctacggaa aggattgcag cgttttatcg aagaaaatga ctgccacctt gccatcagcc
     2761 ttcactctcc gctgaccgtt cagcgtgctg aattaatgcc ggcggaaaag gcgttttcaa
     2821 tcaccgaaat ggtggaactg ttaaaaaact atgattttag taaacaacgt cgactttcgt
     2881 ttgaatatat tgtttttaaa gggctcaatg attcgcaggt ctatgccaaa gagttgctga
     2941 aacttcttcg cgggctggat tgcagggtga atctgattcg ttttcatgcc ataccggggg
     3001 tagaccttga gggggcggat atggatacga tgacccgttt tcgtgattat ctgacgtcac
     3061 acggactttt caccactatc cgttcatcca gaggcgaaga tatttttgcc gcttgcggta
     3121 tgctgtcgac agcgaaacag gagaaaaata atgaaagtta atatataaaa ccgaacatca
     3181 tgaaaaagta ctcttttatt ttatgcatcg ctttggtagc ctttgtcgtt gcatcttgtg
     3241 gtctgaaagg aaatcacacc tctagtggtc gtgcttacga gcttttggtt gtagtagatc
     3301 acggtgtttg ggatcgtgct gccggaaggg ctttacatga tgcgctcgat gctgatatgc
     3361 ccggtttgcc gcagtcggaa ccttctttcc ggattatgta tacttcaccg aaagattatg
     3421 attctacgct gaagttgata cgtaacatta ttattgtaga tatacaggat atatatacga
     3481 aagcctcgtt caaatatgcg aaggacgtgt atgccaatcc gcagatgata ttgactatcc
     3541 aggctccgaa cgaagaagag tttgagaagt ttgtggaaga gaacaaaaag acgattgtcg
     3601 acttctttac ccgtgcggaa atgaaccgtc agattacgtt cctggaaggg aaacacagta
     3661 atttcatttc gcagaaagtg gacagtttgt tcggatgcga catctgggtg gatgccgaac
     3721 tggctaattc aaagaccggg gatgatttct tctgggcttc taccaacaca ggtactgccg
     3781 accgtaactt tgtgatgtac tcttatccgt acactgacaa ggatacgttt accaaagaat
     3841 attttgtgca caaacgtgac tccgtgatga aagccaatat ccccggattc aaggaaggcg
     3901 tttatatgtc gaccgatagt ttgctgaccg atgtccgtcc gatcaatgta cagaacagct
     3961 acacaatgga agcacgtggc ctgtggcgta tgaagggcga ctttatgggt ggtccgtatg
     4021 tgtctcatac tcgtctggac gagaaaaacc aacgaattat tacagcagaa atatttgttt
     4081 attcacctga taaaatgaaa cgcaacctgg tacgccagat ggaagcatct ctgtatacac
     4141 tgaaacttcc gaatgaagtt cagcagaagc agattccatt gggagaagca tctaaggaag
     4201 cggaacaaac taataaataa aaacatggaa gataacaaga taaggatagg tatcacccaa
     4261 ggagatatta acggggtggg ctatgaggtg attcttaaga cattttccga ccctacgatg
     4321 ttggaactat gtactccgat catttatggc tcaccgaaag tagcggctta tcatcgcaaa
     4381 gcgctggata tacagaccaa tttcagcatt gtcaactctg ctaccgaagc ggggtacaac
     4441 cgtttgagcg ttgtgaactg tacggatgat gaggtgaaag tggaattttc caaacccgat
     4501 cccgaagccg gtaaagctgc gttgggggct ttggaacgtg ccatcgaaga atatcgcgaa
     4561 ggattgatag acgttatcgt aacagctccg atcaacaaac atacgattca gtcggaagag
     4621 ttctccttcc ccggacatac ggaatatatc gaagaacgtc tgggcaatgg tgataagtca
     4681 ttgatgattt tgatgaagaa tgacttccgg gtggctttgg tgacgacaca tatccctgtc
     4741 agagagattg cgactacgat taccaaagag ctgattcagg agaaactgat gatattccat
     4801 cgttgtctga aacaggattt cggtatcggc gctccgcgta ttgcggtgct ctctctcaat
     4861 cctcatgccg gagacggtgg tttgttggga atggaagagc aggaagtgat tatccctgcc
     4921 atgaaagaaa tggaagagaa aggaatcctt tgctacggtc cttatgcggc cgacggcttt
     4981 atgggttcag gcaattatac tcattttgac ggtatcctgg cgatgtatca cgatcagggg
     5041 ctggctccgt tcaaggcctt ggctatggaa gacggggtga actatacggc aggactgccg
     5101 gtagtacgta cttctccggc tcatggaacg gcatacgata ttgcaggtaa gggagtggct
     5161 tgtgaagatt ctttccgtca ggcaatctat gttgccatcg acgtgttccg taatcgtcag
     5221 cgggaaaaag tggctcgtgc caatccgttg cgtaaacagt attacgagaa acgtgacgat
     5281 agtgataaac tgaagctgga tacagtagac gaagattaaa aacgagtgat gacgaaagca
     5341 gagatacaac aagtgaaaca gcgtttcggt attattggaa atactgaagc attgtcgcgc
     5401 gccatagatg ttgccattca ggtagctcct accgatttgt ctgtgctgat taccggagaa
     5461 agtggagtcg ggaaagaaag ttttccgcag attattcatc aatatagccg gaggaagcac
     5521 gggcagtata ttgctgtcaa ctgtggtgct attccggagg gtacgattga ttccgaactg
     5581 ttcggacatg agaaaggtgc gtttaccggt gcgattggcg aacggaaagg gtactttggc
     5641 gaagctgacg gcggtactat ttttcttgat gaagtagggg agttgccgat gtctacccag
     5701 gcacgtttgc tccgtgtact ggagagtggc gagtttatga aagtaggttc gtccaaagta
     5761 caaaaaacgg atgtgcgtgt ggtggcggct accaacgtca atctgacaca agcgattgca
     5821 gaaggacgtt tccgtgaaga tttatattac cggttgaata cggtgcctat ccagataccg
     5881 cctttgcgtg aacgtggtga cgatgtgctc ctgttgttcc gtaagttttc cgcagacttt
     5941 gcagagaaat accggatgcc tgctattcag ttgacggagg atgcgaagaa agagttgttg
     6001 gcttacccgt ggccaggaaa cgtgcgtcag ttgaagaata tcaccgagca aatatctatc
     6061 attgaaacca atagggagat ctctgctgct atcttgcaga attatcttcc cgcacaaaat
     6121 acgcaacgtc ttcccgcgct gatgggaacg cgtgagagta aaggctttga gagcgaacgg
     6181 gagattcttt attctgttct gttcgatatg cgccaggaag tggcggagct gaagaagatg
     6241 gtgcacaacc tgatggcgga acgtgccgga caggtggggc aggtaggaca aatgggaacg
     6301 gtggttacta ctccggtagt gacggcgcat caaccttcgg tacctgctat cattcacacc
     6361 atgcagccta cggtttgcaa ggatgatgat gacatacaag acacggaaga atatgtagaa
     6421 gaatctcctt tgtcactgga cgaagtggag aaagaaatga tacgcaaagc acttgagagg
     6481 catcatggaa agcggaagag tgcggccaag gacttgaata tttccgagcg tacactctat
     6541 agaaaaataa aagaatatga attggattaa gaaaataata cgccctttgt tactgttcgg
     6601 cttgccgttg gtagtcattg cgtgcactgt ttcctataag tttaacggat cgtctatcaa
     6661 ttatgataag gtaaagacca tttcgatagc cgacttcccg atcaagtcgg agtatgtgta
     6721 tgctccgttg gcaaccaagt ttaatgagga cctgaaagat atcttcatcc ggcagacccg
     6781 tctgcaactg ctcaagccga gtcaaaatgc cgacttgcag attgacggag aaatcacagg
     6841 ttacaatcag tacaatcagg ctgtatctgc cgacggttat tcttcggaga cgaagttgac
     6901 tatcaccgtt aatgtacgtt ttgtcaacaa caccaatcat gccgaagact ttgaacaaca
     6961 gttttctgcg ttccgtacct acgactctag ccagttgctg actgccgtac aggacggatt
     7021 gattgctgaa atgtctaaag agatcaccga ccaaattttt aatgcaactg tagcaaactg
     7081 gtaatataaa tgacttctgt taactttcaa caatggattc agcatcccga gacgctgaat
     7141 agggatactt tgtacgaact gcgcaatctt cttgcgaggt atccgtattt tcagtcactt
     7201 cgtctgctgt atctgaagaa tctgtatatt ctccatgata ttagttttgg tggagaactg
     7261 cggaaagcag ttctttacat tgcagacaga cggcagttgt tccggttgat tgaaggtgac
     7321 cgctatgatg tgcaggcacg gaaaaaggga gtacctctca cggaggtgct gaaagacgaa
     7381 ccgtccgtag accgcacatt agcattgatc gacgctttct tgtccacagt acccgaagag
     7441 gtgactgccc gcaccagctt cgactattcg atggattaca cctcttatct tttggaggag
     7501 actccggcca cggaacagcc ggccgaagaa acgcccaaac tcaaaggcta cgaactgatt
     7561 gacgacttta tagaaaagag cgagagcgac tctcccctct gcaagaaacc tttaagagaa
     7621 gaaatgccat cttcgccaac ctcttcggac gaacttaccg aagaagaaac gatgaaggaa
     7681 gaagaggaag atgacagctg ttttacggaa actttggcaa aaatctatgt taaacagcaa
     7741 cgatattcaa aagctcttga aataattaaa aaattaagct tgaaatatcc aaaaaaaaat
     7801 gcttactttg cagaccaaat cagatttttg gagaaattga ttattaacgc taattcaaaa
     7861 taactaaaaa tgtacttatt attcgttatc ttaatggtta ttgcagcctt gttgatgtgt
     7921 ttcatcgtgc tgattcagaa ctcaaaagga ggcggacttg cttctggttt ctcttcatct
     7981 aacgccatca tgggcgtgcg caagactaca gattttctgg aaaaagcaac atggggctta
     8041 gctatcttca tggtggtaat gagcattgct actgcttatg tagttcctcg ctctgctgtt
     8101 gctaaagacg cagtgttgga acaggcacag aaagaacaac agactaaccc gtataactta
     8161 cccgcaggta cggctgcgcc gcaaactgaa gctcctgcta ccaatgcacc tgctacagaa
     8221 actccggcac cggctactga aactcctgct cctgcagcag agtaattcac tccgttgtca
     8281 ggtaagactt tggggtaaaa ccattaatgg gaaggtgcag acggatgctg catttctttg
     8341 atatttaagt gcggattacg cagattacac ggattttcaa tcttccgcgt ggtcagtgta
     8401 atccgcactt aactttttct tgtaaaaaca atctcttttt gatagaaaca aacgagattt
     8461 aactaccttt gttggtcgta tgaagattat taactactat ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactact atgggacagt cttgattatg gtttcttcac aagcgcttac
     8701 gggtggttta atgtattcct attgatgctg attttcggtg gtatcatttt ggataagatg
     8761 ggagttcgtt tcaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtaaccctgg ctgcattggg gtatgctatc ttcggtgtag gtgtggaaat tgccggtatc
     8941 acagtttcca agattatcgt aaaatggttc aagggtaagg aaatggcatt agctatggga
     9001 cttgaaatgg ctacggcacg tatcggaaca actctggcaa tggtgctcac ggttcctttg
     9061 gccgactttt tcggatctac ggatgagagt ggcacatttc ataccaatat tcctgctccg
     9121 attttgtttt gtctgattat gttgtgcgtg ggtacgattg ctttcttcct ttatactttc
     9181 tatgataaga agttggatgc ttctttggat gcagaaggat tggagccgga agagccgttc
     9241 cgtatgaaag atattgtgta tatcattacc aataaaggat tctggctgat tgcattacta
     9301 tgtgtattgt tctactcggc tgtattcccc tttatcaagt atgctgccga cttgatggtg
     9361 cagaagtata acgtagatcc gaagttggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcgattatcc tgactccgtt gttcggctcg ctttatgacc gtatcggtaa gggagctacg
     9481 ttgatgataa tcggatcagt gatgcttatt tttgtgcata cgatgtttgc tctgcctata
     9541 ctgaatatat ggtggtttgc tactattatc atgattatat tgggatttgc cttctcgttg
     9601 gtgccttcag ctatgtggcc gtctgttccg aagattattc cggaaaaaca gttgggtacc
     9661 gcatacgcat tgattttctg ggtacagaac tggggattga tgggtgttcc tttgttgatc
     9721 ggatgggtgt tgaatactta ttgcaaaggt ccggtagtag acggtgcaca gacttatgac
     9781 tacacgttgc cgatggctat ttttgctctc tttggtgtgc ttgctctgat tgtggctttg
     9841 atgttaaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactaggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacaaaa
     9961 gggtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttcgtga gattatagaa aaactcgcag accactttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagttgtata aataggaact tattattatt tatttgataa
    10381 atacagccca aagtatgacg gcaattgcta tcaggacccc catgataata agcgttcccc
    10441 aaacaaaata attgctgtct ttctctttct ttttctccga gtcgtggatg atacgttcca
    10501 tttcttcggg ggtggtgttg ggtagtggat aaggttcgtt tgcacggttt agatgcttca
    10561 acttatcgtt agcacgttca cgacgtaggc gggaagcttc ccgtccctct tttattcggc
    10621 gtatcatgtc gaatgcatgt ccttcaccaa ccatattctt tgttttttag aagtttactt
    10681 cctcgttttt ctatttccct tcttctctgt ccactttgag caatcctccc gtattcggat
    10741 caaaataaac tttgatggta gaattcttgt tgaacaaaac cggagccaga tattctatca
    10801 caccaaattg agtaatagga agttcacctt cgtaaagttt ctttttaccg tcggtcagtg
    10861 taaccatagc ttgtccgggg acgttgtagg cgattccatc caaatctttc ttcttcttac
    10921 cgtcttcctg tggcatcttg accgatttca ggtctttcag actgatataa aacggagttc
    10981 ctgccaaatc attgttggca actacaccta acttcttcga gaagcggaaa gcaacttcat
    11041 tgttgagttc cttgtcagga gtaaggcgga cagtgaatgt tctctcttct ttgttgcagg
    11101 tgccggagaa catttgcgtc atggcttctt cctgtgcatt cagattgtcg agcataatct
    11161 taagctgtgc cccatctgaa ggcatattat cagcctgtcc gcgcaataag gcatttttgc
    11221 tttcgcggat gttatagatc tctttagcca ccagctcggc catcttagcg gtagagctag
    11281 ccatcagaat ctcttcggtc aggaattcgc gaggattcgc tttcttttgg aggactgcgg
    11341 gggcgggagc agcttttttg cctacactgc tattgctgta aggaacattg atcgttttca
    11401 caatgccatc ctctgtcagt tccataagcg gtgctactgt cttatccttc aattttacga
    11461 aatacgtagt ttcgctgttg ggcacaccta cggatttcac ttttacgcta gccagttccc
    11521 agtactcttc aggatcggcg gaaacattag tcaaccgcag gtaacgatca gcatatttgc
    11581 tgaattctcc cggagtatag ttgactttgt tggcttttat ttcaagttct atttgggttt
    11641 tgggaagact gtaaaccact ccatagtctt ttcctcgggt aacccctgtc agtacttcgg
    11701 tttgtgcata ggcggacgtt gtcataagta gtcctgctgc tataatcaac tttttcatat
    11761 tcggttcttt tttaactggt tttgaaaaca aagttaatga agttattgaa aaaagggtaa
    11821 cttcttaact tttattcgct tacaagtcgc catgctgtcg gcagacaggt gataatatcg
    11881 cttgcgatca ttccgatcat tccttgcttc ttttgagcga catcgcccgc caatccgtga
    11941 atgtaagtgc cgattttagc ggcttcctcg gtggggtaac cttgggcaag cagtgccagg
    12001 attactccgg tcagtacgtc accgctacct ccggttgcca ttcccggatt tccggttggg
    12061 ttgaagaagc atttaccttc gggggtgata atggcggagt aggctccttt taaaataatg
    12121 tgaacatggg cggcacgggc cagttcgcaa gccttcatca gacgttcgta agagtcctgg
    12181 catttgccgg tcagacgttc cagttctttc ggatgcgggg tgaggatgga acccttcggt
    12241 aggtgggtaa gggtatggcg gtggttggcg aggatattaa gtgcgtcggc atccactaca
    12301 acaggagtct ggcagtgttc cagttgttcc aacaaggctg cttccgtttc ctcgtttcgt
    12361 cccagtcccg ggccgatgcc gactgcttga tagtcgtccg tgtcggtagg tacggcaaaa
    12421 caggtttcgt tgatgtcggt ttctacgatt gcttcgggta tggaggtttg caagatgtcg
    12481 ttgttgcaca ttggcgcatg gacagtcagc aaccctactc ccgaacggag gcaggcgcgg
    12541 gcagcgagaa cagaggctcc tgccattcct tttgaaccgg caatcaatag tgcatggccg
    12601 aagttcccct tgtgggcaaa ctgtttgcgt ggcttgatga gtgaacggat ttgctctatt
    12661 tccaacattt cgtagttcgt ttccatctct tcaataccgt cttcgcttaa ttggatgtcc
    12721 agcacttccc attctccgac aaattccgtg ttctctgcga aaagaaaggc gagcttcggc
    12781 agttgcagac tgaaagttac gtcggcacgg ataatattag cttttacgtt gaatgtgttt
    12841 tcttctccca tcagtccgga aggaatgtcg atggctacta ccatagcagg ggaggaattg
    12901 atgtatttca ctacggcagc gaatccgccg ctcaacggtt tgttcaggcc tgaaccgaat
    12961 aatccgtcga ttaccagatg gtcgggcgtc agggcgggag gtacgaattg ggtactgatc
    13021 tcgtggaatt ttacttcttc catcatttct accagttctt tattggtctg gcagtcgggt
    13081 gaaagttctc ctttcgtgtt gaagagaaat acctcgattt tatatccttt ttcagccatc
    13141 atgcgggcta cggcgagagc gtctccgcca ttattccccg gtccggcaaa gatagtgacc
    13201 ggcgtttccg tattccatct gtctgtgatg gcttttgtta atacggttgc tgcacgttcc
    13261 atcagatcga ttgatgcaat aggttcgttc tcaatggtat aagcgtccaa tttcttgata
    13321 ctgctgcttg gaaatatttt cattgcgatg ttcttttagt tttcggatta caaatgtaca
    13381 tgattcttct gacttttccc gtttgttgtg ggaagaaaac cataattgca acttttaatt
    13441 catcattagt tctatctttg ggtcagagaa atatctgctt ttgaactatt aagtgttaga
    13501 ataactccgc caaaaaataa ttcaatgcag caccattatg aacttacttt tatttctcct
    13561 gaaaaagatt tctggttctt cgtcaaattt ggtggtaatc tcttttttat ttcaactgtc
    13621 ttcttctttc ttaatcctat taaaagttgt ag
//
