LOCUS gnlProkkaAKHABFJA_24 16666 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|AKHABFJA_24. ACCESSION gnlProkkaAKHABFJA_24 VERSION gnlProkkaAKHABFJA_24 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 11:36:19 Original ID :: gnl|Prokka|AKHABFJA_24 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 16666 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..16666 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[2704:6666]" /cutoff="20000" /detection_rule="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="1" /tool="antismash" proto_core 2705..6666 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="1" cand_cluster 1..16666 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /kind="single" /product="lanthipeptide-class-i" /protoclusters="1" /tool="antismash" region 1..16666 /candidate_cluster_numbers="1" /contig_edge="True" /product="lanthipeptide-class-i" /region_number="1" /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))" /tool="antismash" CDS 3..251 /locus_tag="ctg21_1" /transl_table=11 /translation="MLSNGIVGFVVVAAGMVGNATAADMTAANIRTFKTCAYYLPLAGI VASLVVFLLTVKIDENMHDRIVEQLEARLASEETDKQ" CDS 669..1325 /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 140.9; E-value: 8.7e-43)" /gene_kind="transport" /locus_tag="ctg21_2" /transl_table=11 /translation="MPVISATNLSIGYKNSPIVSDINLRLNTGRIVCLLGANGAGKTTL MKTLLGRIRPVSGEVTYTGTNINEMSAAIDHPSFFPYLSGRENVEVVSAFWGLDVDPET ALNNVGINHAAHGRKAKDYSTGMKERLELCLALVPHPRFLFLDEPQNGLDPDGIASLSE TLRAYRDRGNCVVISTHLLHEIQGVPDECIVIRHGRAAQFTDLTGVNLADLYQGR" CDS 1328..2056 /locus_tag="ctg21_3" /transl_table=11 /translation="MSAVSPVRALVAYYWNVWYFLAAVFGAVASLLLGSWISGAANGTP IAGGYSFFFTGTQPVICLALLFVCDARVAKAHYGGLPRHVYSAWKPCSLRTIFRALILA AVNLLSVLCFDVIMVLMGTGMHPNLAVVLCFVVLQSLLTALIYSIVEIAVNPEVAGIVS AILCYVWVLLPGDLSDYATPYVANALRVVGLNLNGTVMSPAETASRSSVGPVVVVVPIV VLLVVYVLLSWFRREGVDRK" CDS 2053..2679 /locus_tag="ctg21_4" /transl_table=11 /translation="MKSLLRIERVALIRWSMLAFVAVLLLPLFFLRYGSMGAVAQSAMV MALPITTAGLVFSHARVPRSYRSFSIHDRLLLRFTLKSLLLGVAVSICLTLLYGFAVGF IVNKRPLSLHVALMFAFTAVVLSLACFVLRLWASPVVAWSIVGFFIVAGLPVSSGMFEG SPILHAVIPTTWMLSGARFAGYVIPVGVVVAMASAWLLLKAVKRV" CDS 2705..5464 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_C" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_N" /gene_functions="biosynthetic-additional (rule-based-clusters) Lanthipeptide_LanB_RRE" /gene_functions="biosynthetic-additional (smcogs) SMCOG1155:Lantibiotic dehydratase domain protein (Score: 201.6; E-value: 2.7e-61)" /gene_kind="biosynthetic" /locus_tag="ctg21_5" /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-09, bitscore: 28.9, seeds: 20, tool: rule-based-clusters)" /sec_met_domain="Lant_dehydr_N (E-value: 9e-29, bitscore: 90.1, seeds: 73, tool: rule-based-clusters)" /sec_met_domain="Lant_dehydr_C (E-value: 3.6e-13, bitscore: 39.8, seeds: 35, tool: rule-based-clusters)" /transl_table=11 /translation="MRIAALPVDKFPKKGSSALSVFADTVISEPGIRAVLENSAPSFYA AVTKNLAEDSKTERTKVLKVARSALKYLSRLTTRATPFSTFATVGVLENVVSNPDGLEL EVGQRRILERIAVGIDDIEKTFTFNPSAYLLGERLYIPSPSKSQETISVRYSEAVQAVK QVTEGRLIGLEQLSSTLATKFGTSEGLSAFIDGLIDSGILLAAPISYQMRDWKEDLASS DVTSTVQLFSLARFSGTFPSNLIDDTGLAIELMGRLFSFSTQNRNIESFTERYISRYGN FRFPANQVIDNYDGIGLLPPLESEDLQPAGQGKARFDLTNKFLSEVIFTNSDKSSIDLS RYASRILREWPAVEFASSYDVILKVEKVNSQTCEASTNFVFDDIGTIPLAGRAMARFAE LSAEMKNNHREIVTRASGLERTERLPLLYRYNSPRPDFLSGNSSVSGNALSLGFLPHVE QAVSIVGLSDISVFESSGKMYCFDERHQKVANIHLPGLVNQDLLSGIGRSLVQISQMNQ ATPYWSWLGYENHANHLPEIRLGVTILSREKWKLTNRGIGALDDLKRVLADRRVPRYIY AGASDNKILLDTSAFDHLRLLKHVIENSDEDIWIERGVEPEDLGVTKSESDDKARFATE IVISVSSTDWAETATLPVAQIPPVGLNLDLSKRSVLESSTAFTFVVLCNDSNQERVLAT AFDVLDDAGLEAYFVRYSEEGRPSLRIRVRGSFDDTFIRVFCDSVLSLRLATDVEFNLR LPEYSRYGGPECFKYLESFWCLESTQLVKMFTRLSSDTPEQVQKAKSNYMRFLIQQLGF TRHYVSAVAESYEHEFEADRHSIRKAARALRSVFSSDDMPEVFTDEMQEVLARFSSCQL QSNASAQDVKQSIAHMSANRLGLDRKDEAIFWRALLNHLRSADFGGEE" CDS 5461..6666 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: LANC_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1140:Lanthionine synthetase C family protein (Score: 104; E-value: 1.3e-31)" /gene_kind="biosynthetic" /locus_tag="ctg21_6" /sec_met_domain="LANC_like (E-value: 1.1e-23, bitscore: 73.7, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MKTRNDIQQEVTLIASNLEDIIPIRYQEANRTKSFNINGGTPAAI LYLSVLDALFPDAGYDVQAHNYATSMILEYKHTPNIGIGLFGGTTLLAWCLQSISRGGS RYQGAIRELESRIVFQARQQLTFLSNVNAPISSEYYDVISGLSGVVLYGMRFRSDGLRL ISRQICSRFCELLATSNFHAFGSLSATSGQDSVAQKTTTDYGYAHGILGVLMSCILSDV NHDNNMEPFAAIRQLVDISNHSRNYILPYSSSDYTETVSNGRYAWCYGNMPFYFLSLML KPVDPIIAESLLNVAIAPLKVNTSQVHDLGVIGLVDNSICHGRAGIVLGLHPYLSHKDS RPIRDQLLEEIDCSVANPIDSGFLEGDLGTLAVRVALEYTDSIAHLPAFFPFVSPTLWE GI" CDS 6663..7535 /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 139.1; E-value: 3.2e-42)" /gene_kind="transport" /locus_tag="ctg21_7" /transl_table=11 /translation="MIARALNVTLIYGKSRNPVLHSLNLEIDSGQVLPILGGNGTGKTT LLKALSGLLRPHLGRILIDDSDLYQKRGSALRRLSSSLYSERSFYYRLSARENLRYFLS LRGIYGRTAMSSIDMALDRFDLLGLQDIPFMHLSLGQRKRLGLARAFAAPASLYILDEP TANLDAKSCRLVYQAMTDKSADGASILFSTHNVADLATSTGNVIYLKNGNATRVHLETR DSITARKRFRIVGSLDPESIASIPEVSCVISQSEVEVDIPVGKSLGSVLQSFERIGIEV NEVIDDRSR" CDS 7537..8346 /locus_tag="ctg21_8" /transl_table=11 /translation="MHSFLIGLYLYLRREFLELVTYKLSLMLGVVSAVVGIVQFAFLAV FLQQGNSFPSLQNYGGSVMAFLVSGALFTGFMSSSLSSFSQLISSEQRTGTLEAVLTTP FSIGRVIAYAAVSSFIQLVIGTFLMITFFGIAFSIPFNVNPWQLILVMILGYFTLVGLG LAGGGVLLVTKKGDPVTWLLTTFTTLFSGVLYPVEILPQWLQSISWYVPTTRILSSLRG ALTGYTSMFMLDVVYLIVASIVSMSIGLLVFRWGLNRAIWDGSATSY" CDS complement(8640..12935) /locus_tag="ctg21_9" /transl_table=11 /translation="MRFGKKGAGAVASITAAAALLACLVPVALADNGGGGSGEDGGGSG GGPTQTADVHWIYKDSWPATLDGMKTALSDAKVRLSSDLANGQNQFVNMNKTLSDAIDE CQRSYTGEGNADCRLVAVGYVRLADGSFNGSYVSSNAKNRWEAQWKAEAKGDYTYQGQK YSTSTTWKDKLGTRSVDSLAQESIDSNPNASFRVIVLAQNQPPVDYKLNVTTSHKQKTD MQVGSTDPIGDVIHADNGGSAIRETLNGTAIIHYENGPYLPAKSVSKPISFPSNGDTQL DDLASPKDFGMEHWAEGTYWIDIQVPKQGRMQAAVDTADRDPTESWKVSSVPPEPPVKK IEDGVSADRMTNRTTITYGTGRGGYEMRFRDVIEPNGVEYSVDNYRLIDRIDGNRDVSG EFEINWDKASNTVSAARSADKGEMPMDHVYEFSFDVTVSKPSDFQQVKDHAWGKWNHEP EADAGKKQFDTWRPNPDKSWIRLNAKGQWEAVIDPKETNRTGADDMTLLDGDRVASVVN GTIAKNLIQAPETLTLTDDWSAADYLFDADDKSKIKVYEADAGTDRESSVTDIANHGRD VTDQWTITMEGTTVTATAGRAYREGLKGLKTAKQVTLLIPGKAAYANGKGAGQVRDDFG KQASDELSFCTAPDGKALTNKGSQTVNTHTIPTNEPKICGYIPPVVKDVVGESSQGGDQ ASVDGRVVYPGQRLEYRLETQPHLPGNLAYSVSEVAVTDTYDEHLEVDKQTLEVTDLST GRFIPKTEYETQWNDAQHAVRLVFSDGYVKTNWRNGANPRIIVRFEGTVAKDAPTDTKI GNQWALTLNNMITPSNKVWNEPPDFTPVKKDTQADPSISIDGKTALLGDRIYYRVTIDA KQTNQAYKVWRLGMTDDWDDEYLSLDAKRIEVTDTATGKDVTAKFNIAAIDGVAYVYAK TADTKVPATGETIKGDPQPKNLKEYAEKKDHDPLKEPAIDQSMLGTSYEVSLPMTVIKV TDGHIVKNKATQVVNDTRKDTNEVANPLKPVNPSKDVVVKVDGESIDKRSVYLNGLFLY RLDSSVLPAHRAYQKVTDWSITDPLDTEHDQYTGQWAVYAMRDLTEQGRVIARKGVKIA GSGFDASVYGGELFTLTQDDKGVVTVTATQRMLDLVSGNDESEQAWTAFIQCKRVKTGE HIANRFDETLNGTKRPSNQVETHTPDMTPSLKIEKWDEASGWPAGDRDQVKDALAMQGD TRIVFTITNTSTTDPDTKQGAWYRTKDLNLKDQLVAGDGRVTDLEYPADWDSRVLKPGE SVEVKGILKGVTDHHTDRATVTGTPLVECVVSDPDPFDGKDETSAPDDAVTIDGRLVCP DTEVVSNTDDWNGYRTGLAHTGAAIQGVIAAAITLLAVGVGLVAARRFRHGNSAGGRHS ESAQSSDIADTDEDVAETTDEIPYESSVS" CDS complement(13240..13551) /locus_tag="ctg21_10" /transl_table=11 /translation="MSQRIHLSENQLHAGLVFPQMKETTPVKKRPIVRTILFPNSSRAL VDKTGKILSVLMGPEQIIGISGFQIRTRLGKNGVQCRSDWGQNVRKCVDLVQIDKIFR" CDS 14047..15252 /locus_tag="ctg21_11" /transl_table=11 /translation="MSTFNPEGIALKQRLAFNPERIALARRLEGVTQKELSTRSGLSQA KLSKLQNGIISFNESDAVKLSGALDYPISYFEESGTVIPLSELTYRKTSRSSMGELNSV STEYSLLMDVIQKLCHVLKMKKNPAAWIDEIAPHEQSLSEEKIERLAIRTRECLGLKPD GAVPNVTRAIERAGIIVSPMRSLNMRGGANLTSEGVTAPSSQWHAMCIGYLGNGALGGD RLRFTKAHELGHLILHRYRKPDSPQLVEREAHIFAGAFLISQLDARLVLKSNLSLRDFL PIKAGWGISIAALISRSHNLGIIDRQRYTSLNIQLSGKGWKKQEPVPVGIENPLLLKQM ITSAYGFKTDQGLKIDSIGLASELGAPFRYLDYWSDGLDDEGMHWGIAANRFEQRPNRM IA" CDS complement(15586..15843) /locus_tag="ctg21_12" /transl_table=11 /translation="MNDNHNENEEPFDGTSEDSTLEDQMSAHIAAIAASGVAAEAEALA NRQADMAAKERRETRLAILAAIGIFGAVIVYIITHIAENH" CDS complement(15990..16397) /locus_tag="ctg21_13" /transl_table=11 /translation="MDYSMEVSVLGDRISIGEEAHVITLGVNTGFPAGSTAGLAYTLSP LQARVLGAQMRAAADAAEGHPGMPSDEEVNAAAKVFCGGVWNGFDPASMMPTEQFDRFW GDGEGHQLYLEIARHALIAARMSILAGQNES" ORIGIN 1 gcgccctgtc caacggcatc gtgggcttcg tggtcgtcgc cgccggaatg gtcggtaacg 61 ccaccgccgc cgacatgacc gccgcgaaca tccgcacgtt caagacctgc gcctactacc 121 tgccgctcgc cggcatcgtc gccagcctcg tcgtcttcct cctgaccgtc aagatcgacg 181 agaacatgca cgaccgcatc gtcgagcaac tcgaagcgcg cctcgcctcc gaggaaaccg 241 acaagcagta agaaatccaa ctacaaacaa aaagaccttg ggtgggttgt catctataga 301 tgacaaccca cccaccactc aagtcgttcg aatcgtaact gcgcaattat ttacagtaag 361 tagttattcg cattgcgggc aactgcttac tgtccattac gttcagattc gaaagattgg 421 agaagtcatg gccacttttg accttgatac ccatgttgag gaaactgagg gggacgctcg 481 tcctctgatt acctcgaagt tcatgtgcac ccctggctgc ccgaccggcg gccttgcctg 541 cttcacttcc caatgtacca atggttgtag cttcaccggt ggaagcaagc attagcaacg 601 tcgtcgtagc atcgtgcgtt cctagaggca agccttgtct ctaggaacgc ctttttggaa 661 ggtggatcat gccagttata tcggcgacca atctctcgat tgggtacaag aattccccga 721 ttgtcagtga catcaacttg cggttgaata cgggtaggat cgtctgtctg ctcggggcga 781 acggcgcggg taagaccacg ttgatgaaga cgctgctcgg gcggatcagg cccgtgagcg 841 gggaggtcac atacaccggg acgaacatca acgagatgtc cgcggcgata gaccatccca 901 gtttctttcc ctacctgtct ggtagggaga acgtcgaggt ggtctccgcg ttctggggtc 961 tggacgtgga cccggagacg gcgttgaaca atgtgggcat caaccacgcg gcgcatggac 1021 ggaaggcgaa ggactattcg acgggtatga aggagcgtct ggagctgtgt ctcgcccttg 1081 tgccgcatcc gaggtttctg ttcctcgatg agccgcagaa cggattggat cccgatggca 1141 tagcctcctt gtccgaaacg cttcgcgcct atcgggacag ggggaactgc gtcgtcatct 1201 ccacgcatct gcttcatgag attcagggag tcccggatga atgcatcgtg attcgacatg 1261 gccgggccgc gcaattcacg gatctgaccg gggtaaacct cgcggacctg tatcagggga 1321 ggtaaaggtg agtgccgttt ctcctgttcg cgcgttggtc gcctattact ggaacgtatg 1381 gtattttctc gccgcggtgt tcggagccgt ggcgtccctt ctgctgggtt cgtggatttc 1441 aggcgcggcg aacggaaccc cgatagctgg aggatacagc ttcttcttca ccggcaccca 1501 gccggtgatt tgtcttgcgc tgctctttgt gtgcgatgcc agggttgcga aggcgcacta 1561 tggaggtttg ccccgccacg tgtattccgc atggaagccg tgctcgctca gaaccatatt 1621 ccgggctttg attctggccg ctgtgaacct gctgagcgta ttatgcttcg acgtcatcat 1681 ggttctgatg ggtaccggga tgcatccgaa tctggccgtc gtcctgtgct tcgtcgtgct 1741 gcaaagcctt ttgactgccc tgatttattc gatcgtcgag attgccgtca atcccgaagt 1801 cgccgggatc gtctcggcca ttctttgcta tgtatgggtt cttctgccgg gcgacttgtc 1861 cgactatgcg acgccctacg tcgcgaacgc cctacgggtc gtcgggttga atctgaacgg 1921 caccgtgatg tcgccggcgg aaacggcgag ccgatcgtct gtcggccctg tggtggtggt 1981 cgtcccgatt gtggtgctcc tggttgtcta tgttttgttg agctggttcc gtcgcgaagg 2041 agtggacagg aaatgaagtc cctattgcgt attgagcgcg tggcattgat ccgttggtcg 2101 atgctcgcct ttgtggccgt gctgctgctt ccgctgttct ttttgcgtta cgggagcatg 2161 ggcgcggtgg cgcagtcggc gatggtgatg gcacttccca taaccacggc cggccttgtt 2221 ttctcccatg cgagggtgcc ccgctcatat cgttccttca gcatccacga tcggctcctg 2281 cttcgcttta ccttgaagtc actattgctt ggtgtcgcgg tcagcatctg cctgactctg 2341 ctgtacggat ttgccgtcgg atttatcgtc aataagagac cgctctcgtt gcatgtcgct 2401 ttgatgtttg cgttcaccgc tgtcgttctt tcccttgcat gcttcgtcct gcgactctgg 2461 gccagtcctg ttgtcgcttg gagcattgtc ggcttcttca tcgtcgccgg ccttccggtc 2521 agctccggca tgttcgaggg ctcgccgatt ctgcatgccg ttataccgac cacatggatg 2581 ctaagcgggg cgcgatttgc cggttatgtg attccggtcg gtgtagttgt tgccatggca 2641 agtgcatggc tgctgcttaa ggcggtgaaa cgtgtctaga tatactctgc tcggatctcc 2701 atacgtgagg attgcagcgc ttcccgtcga caagtttcct aagaaaggca gttccgcgtt 2761 atcggtgttc gcggacaccg tcatatccga acccggtatt cgtgcagttc tagaaaactc 2821 tgctccatca ttttacgctg ctgtcacaaa aaatcttgca gaagattcga agactgagcg 2881 aacaaaggtt ttgaaggtag ctcgaagcgc gctaaaatac ttatcgcgcc ttacaactag 2941 agcgactcct ttttcgactt ttgcaaccgt tggagtgctt gagaatgttg tatcaaatcc 3001 cgatggtctt gagttagaag taggacagcg acgtattctc gagcggatag ccgtagggat 3061 tgatgacatt gaaaagacct tcacatttaa cccatccgct tatcttcttg gtgaacggct 3121 ttacattcca tcaccatcaa agagccaaga gacgatttct gttcgttaca gcgaagccgt 3181 acaagctgta aaacaagtaa cagaaggtcg cctaattggt cttgaacaac ttagctcaac 3241 actcgcaacc aaattcggaa cctctgaggg cctaagtgct tttatcgatg gccttatcga 3301 ttccggcata ctccttgccg caccaatctc ctatcaaatg agggattgga aggaggatct 3361 agcatcgtca gatgttacct caaccgtaca gctattttcg ctggcacgat tcagtggcac 3421 gtttccaagt aatctcatcg acgatacagg attggcaatt gagttgatgg gaagactgtt 3481 ctcattttca actcaaaata ggaatattga atcctttacg gaacgctata tttctagata 3541 tggtaacttc cgttttcccg ccaaccaagt tatcgataac tatgatggca ttggtctgct 3601 tccgcctctt gaatcggaag accttcagcc tgcagggcaa ggtaaagctc gatttgattt 3661 gaccaacaaa tttctatctg aggttatatt tacaaattca gataagtcaa gtatcgattt 3721 aagccgttat gcttctcgca tattaagaga atggccggca gtggaatttg cttcatccta 3781 tgacgtcata ctgaaagtcg aaaaagtaaa ttcccaaaca tgcgaggctt cgaccaactt 3841 tgtgttcgac gatattggaa caatcccttt agcaggacgt gccatggcta ggtttgctga 3901 gctctctgcc gagatgaaga acaatcatcg tgaaattgtc acccgagcat ctggccttga 3961 gcgcaccgag agattaccac tcctatatcg ttataattcc ccgaggccgg attttctaag 4021 tggaaattct tctgtatccg ggaatgctct atccttggga tttttgcctc atgtcgagca 4081 agctgtttca atcgttggtt tgtcagacat ctcagttttc gagagttccg gcaagatgta 4141 ctgcttcgat gaaaggcatc aaaaagttgc aaatatccac cttcctggct tggtaaatca 4201 agacttgcta tcgggaatag gtagatcatt ggtgcaaatc tctcaaatga atcaagccac 4261 accatattgg agctggttgg gttatgaaaa tcacgctaat cacttaccgg agatccgcct 4321 aggagtcaca atactatcac gagagaaatg gaagttgact aataggggaa ttggggcgct 4381 tgatgatttg aaacgagttt tggctgatcg aagagttcct cgatatatct atgctggtgc 4441 gtcagacaac aagattctgc ttgatacttc agctttcgac catcttcgac tcctaaagca 4501 cgtcatcgaa aactctgatg aggatatctg gatagagaga ggcgtcgaac cagaagattt 4561 aggtgttacg aagtctgagt cagacgataa agctaggttt gctacggaaa ttgtcatttc 4621 ggtttcttcg actgattggg cggagacggc gactctgcct gtcgctcaga ttccgcccgt 4681 cggtctcaat ctagacttgt caaaacggtc cgttctagag agttcaaccg cttttacctt 4741 tgttgtgcta tgcaacgact ctaatcagga gagggttctt gcaactgcct ttgatgttct 4801 tgatgacgct ggtctcgaag catactttgt tcgctactct gaggaaggtc gcccaagttt 4861 acgtatccgc gtgcggggaa gctttgacga cacgttcatt cgggtgtttt gcgattcggt 4921 actctcgcta cgcctcgcga cagatgtcga attcaatctt agacttcccg agtattcacg 4981 gtatggaggt cccgagtgct ttaaatattt agaatcgttc tggtgtcttg agagcaccca 5041 actggttaag atgtttaccc gcttatcatc ggataccccc gagcaggtac aaaaagccaa 5101 aagcaattat atgcgtttcc ttatccagca actggggttc accagacatt acgtatctgc 5161 cgtagcagaa agctatgaac atgagtttga agcagatcgg cattctatta gaaaagccgc 5221 cagagctctg cgaagtgttt ttagttccga cgatatgccc gaagtgttta ccgacgaaat 5281 gcaagaggtt cttgcgcgtt tttcatcctg ccagcttcaa agtaatgctt cagcccaaga 5341 cgttaagcaa tctattgcac acatgtctgc aaatcgcctt gggcttgatc gtaaagacga 5401 ggccatattc tggcgggctc ttctcaatca tctaagatcc gcagattttg gaggtgagga 5461 atgaagacac gtaatgacat tcaacaggag gtgaccctca ttgcaagtaa tctcgaagat 5521 atcatcccca ttcggtatca agaggctaat cgtacgaaaa gctttaacat taacggaggg 5581 actcctgccg caattctata tttaagtgtc cttgacgcat tatttcccga tgctggatat 5641 gatgttcagg ctcacaacta cgcgacaagc atgattttgg aatataaaca taccccaaac 5701 attggaattg gactgttcgg ggggaccaca ctattggctt ggtgtctgca gtcgatttcc 5761 cgtggaggaa gcagatatca aggcgcgatt agagaacttg aatcgaggat cgtctttcag 5821 gcaagacaac aattgacatt tttatcaaac gtgaatgcgc caatatcatc cgaatattac 5881 gacgttatat ccggactctc tggcgtggtt ttgtatggca tgcgattccg gtccgatggg 5941 ctgcgattga tttctcggca gatttgcagt agattttgcg aactattagc aacttcgaat 6001 ttccacgcct tcgggtcttt atcagccact tcgggacagg attccgtggc tcagaagacg 6061 accaccgact atggttacgc gcatggtatt ttgggagtat tgatgagttg cattctttcg 6121 gatgtgaacc atgataataa tatggaacca ttcgctgcga taaggcagct tgttgatatt 6181 tcgaatcact cgagaaacta catacttcca tactcttcct cagattatac tgaaaccgtt 6241 agtaatggac ggtatgcctg gtgttacggc aacatgccct tctatttttt gtcactaatg 6301 ctgaaaccgg ttgatccaat aattgcggaa tctctattga atgtcgctat tgctcccctg 6361 aaggttaata ccagtcaagt acatgatctt ggcgtaatcg gtcttgttga taactctata 6421 tgccatggcc gagcgggaat agtcctaggg cttcacccct acttgagcca caaggatagt 6481 cggcctattc gcgatcagct ccttgaagag atcgattgtt ctgttgcgaa tcctattgac 6541 agtggatttc tcgaaggcga cttgggcacc ttggctgtcc gagtggcact agaatacacc 6601 gactctattg cgcatctacc ggctttcttt ccttttgttt ctcctacact ttgggaggga 6661 atatgattgc tagagcatta aatgtgacac tgatctatgg aaaatcgaga aatccagtct 6721 tgcatagttt gaaccttgaa atcgattcag ggcaagttct tccaatcctt ggcggtaatg 6781 gaacaggaaa aacgacactg ttgaaagcac tatcggggct acttcgccca cacttgggtc 6841 gaatcctaat tgatgattcg gatctttatc agaagagagg gagtgcactg cgaaggctct 6901 cgagctcgct ctactccgaa agatcatttt attatcgctt gtcagcccga gaaaatctcc 6961 gctatttctt gtcgcttcgt ggcatttatg gcaggactgc aatgtcgtca attgacatgg 7021 ctctggacag attcgatttg cttggattgc aggatattcc attcatgcac ttatccctag 7081 ggcaacgaaa gcgactagga cttgcgcgag cgttcgctgc gccagccagt ctctatatct 7141 tagatgaacc tacggcaaac ctagatgcca agtcatgcag gcttgtctat caagccatga 7201 cggacaagag cgccgacgga gctagtatac tattctctac ccacaacgtg gccgaccttg 7261 ctacctccac aggaaatgta atatatctta aaaatgggaa tgcgacacgt gttcatctcg 7321 agactcgaga ctccattact gcccgcaagc gttttagaat agtcggatct cttgaccctg 7381 aatccattgc atcaattccc gaagtgtctt gtgtgatttc tcagtccgag gtcgaggttg 7441 atatacctgt tggtaagtct cttggatcag tgcttcaatc ctttgaacga attgggatcg 7501 aggtcaacga agtaattgat gaccggagta gataaaatgc attctttttt aatcggcctc 7561 tacctgtatt tgcggagaga attccttgaa ctcgtaactt ataagctctc cttgatgcta 7621 ggtgttgttt cagcggttgt tggcatagtt cagtttgctt tcttggctgt ttttctccag 7681 cagggaaaca gttttccttc attacagaat tatggtggaa gcgtgatggc gtttctggtc 7741 tctggagcgc tttttactgg ttttatgagt tcttctctct ccagtttctc gcaactaata 7801 tcctctgagc agcggacagg tacattggaa gctgttttga ctacaccatt ttctattggc 7861 cgagtgattg catatgctgc ggttagctca tttattcaat tggtaatcgg cacgttttta 7921 atgatcactt tttttgggat tgcattctct atccccttca acgttaaccc gtggcaactc 7981 atattggtca tgattctcgg ctacttcaca cttgttggcc tcgggctcgc gggtggagga 8041 gttcttttgg ttacaaagaa aggcgacccg gtgacatggt tgttgacaac ttttacgaca 8101 ttattttccg gagtacttta tccggtcgaa attcttccac agtggcttca atcgattagt 8161 tggtatgtgc caaccacgcg gatattgagt tctctccggg gggcattaac cggctatacc 8221 agtatgttta tgcttgatgt ggtttacctt atagttgcaa gcatagttag tatgagtata 8281 ggattgctag tatttagatg gggtctaaac agagctatat gggatggttc cgcgacaagt 8341 tattaaataa tcatacattt gggatattga agtttgacaa tatggcatag aaaagcgttt 8401 cttgtcaaat atcatatgaa ctttgggatt gacatactct attagaatat tgtaccagat 8461 taaggtcatt atttcaaaaa aatgactcta ttctaataga atgtttcctt ctttcgtcgc 8521 gccaaaagaa acatcaattg taatccgtaa taatttgatg aatacatgat agttcttcca 8581 atcgtaagat actccgactg gaagaactat catgacggga agcaggtccg acgtccgggt 8641 cagctcacgg acgattcgta aggaatctca tccgtagtct cggcgacatc ctcatcggta 8701 tccgcgatat cgctggactg cgccgattct gagtgacggc cgccagcact gttcccgtgt 8761 ctgaaccggc gggcggcgac cagtcccacg ccgacggcga gcagggtgat tgccgctgcg 8821 atcacgccct ggatggcggc gccggtatgg gcgagcccgg tccggtagcc gttccagtcg 8881 tcggtgttgc tgaccacttc ggtgtcgggg cagacgagcc tgccgtcgat cgtgaccgcg 8941 tcatcgggtg cggacgtctc gtccttgccg tcgaacggat ccgggtcgga gacgacgcat 9001 tcgaccagcg gcgtgccggt gaccgtggcg cggtcggtgt gatgatcggt cacgcccttg 9061 aggatgccct tgacctcgac gctctcgccg ggcttgagga cacggctgtc ccaatcggcg 9121 ggatattcga gatcggtcac ccggccgtcg ccggcgacca gctggtcctt gaggttcagg 9181 tccttggttc ggtaccatgc gccctgcttg gtgtcggggt cggtggtgct ggtgttggtg 9241 atagtgaaca cgatgcgcgt gtcgccctgc atggccagcg cgtccttgac ctggtcgcgg 9301 tcgccggccg gccagccgga ggcctcgtcc catttctcga tcttcaggct cggggtcatg 9361 tcgggcgtgt gcgtctcgac ctggttggat ggacgtttgg tgccgttgag ggtttcgtcg 9421 aaccggttgg cgatgtgttc gccggtcttg acgcgcttgc actggatgaa cgcggtccat 9481 gcctgctcgc tttcgtcgtt gccgctgacg aggtcgagca tgcgctgggt cgcggtaacg 9541 gtgaccacgc ccttgtcatc ctgcgtaagg gtgaacagtt cgccgccata cacactggcg 9601 tcgaagccgc tgccggcgat cttcacgccc ttgcgggcga tcaccctgcc ctgctcggtc 9661 aggtcgcgca tggcgtacac ggcccattgg ccggtgtact ggtcatgctc ggtgtcgagc 9721 gggtcggtga tgctccagtc ggtgaccttc tggtaggcgc ggtgcgcggg tagcacggag 9781 ctgtcgaggc ggtagaggaa caggccgttg aggtacacgc tccgcttgtc gatggattcg 9841 ccgtccacct tcacgaccac gtccttggac gggttgacgg gtttgagggg gttggcgacc 9901 tcgttggtgt ccttgcgggt gtcgttgacg acctgcgtgg ccttgttctt cacgatatgt 9961 ccgtcggtga ccttgatgac ggtcatcggc aggctcacct cgtagctcgt gcccagcatc 10021 gactggtcga tggccggctc cttcaacggg tcgtggtcct tcttttcggc gtattccttg 10081 aggttcttgg gctgggggtc gcccttgatg gtctcgccgg tggccggcac cttcgtgtcc 10141 gcggtcttgg cgtacacgta ggcgacgccg tcgatcgccg cgatgttgaa cttcgcggtc 10201 acgtccttgc cggtcgcggt gtcggtgacc tcgatgcgct tggcgtcgag ggagaggtat 10261 tcgtcgtccc agtcgtcggt catgccgagt ctccagacct tgtaggcctg gttggtctgc 10321 ttggcgtcga tggtcacgcg gtagtagatc cggtcgccca gcagcgcggt cttgccgtcg 10381 atgctgatgg acgggtcggc ctgggtgtcc ttcttcaccg gcgtgaagtc gggcggctcg 10441 ttccatacct tgttgctcgg ggtgatcatg ttgttcaggg tcagggccca ctggttgccg 10501 attttggtgt ccgtgggcgc gtccttggcg accgtgccct cgaagcggac gatgatgcgc 10561 gggttcgcgc cgttgcgcca gttggtcttc acgtacccgt cggagaacac gaggcgcacc 10621 gcgtgctgcg cgtcgttcca ctgggtctcg tactcggtct tcgggatgaa cctgccggtg 10681 gacaggtcgg tgacctccag ggtctgcttg tccacttcaa gatgctcgtc ataggtgtcg 10741 gtgaccgcca cctcgctgac cgagtacgcg agattgccgg gcaggtgggg ctgggtctcc 10801 agacggtatt ccaagcgttg gcccgggtag acgaccctgc cgtccacgga cgcctggtcg 10861 cctccctgcg aggattcgcc gaccacgtcc ttgacgacgg gcggtatgta gccgcagatc 10921 ttcggctcgt tcgtggggat ggtgtgcgtg ttgacggtct gggagccctt gttcgtcagc 10981 gccttgccgt ccggcgcggt gcagaacgac agttcgtcgc tcgcctgctt gccgaagtcg 11041 tcgcgcacct ggcccgcgcc cttgccgttg gcgtaggccg ccttgccggg aatgagcagc 11101 gtgacctgct tcgcggtctt caatcccttc aatccctcgc gataggcccg gcctgcggtg 11161 gcggtcaccg tggtgccttc catcgtgatc gtccactggt cggtgacgtc cctgccgtgg 11221 ttggcgatgt cggtgacgct ggactcgcga tcggtgccgg catcggcctc gtacaccttg 11281 atcttcgact tgtcgtcggc gtcgaacagg tagtcggcgg ccgaccagtc gtccgtgagc 11341 gtcagggttt ccggggcctg gatgaggttc ttggcgatgg tgccgttgac caccgaggcg 11401 acccggtccc cgtccagaag cgtcatatcg tcggcgccgg tccggttggt ctccttcggg 11461 tcgatgaccg cctcccactg gcccttcgcg ttcaggcgga tccagctctt gtcgggattc 11521 ggccgccacg tatcgaactg tttctttccg gcgtcggcct cgggctcgtg gttccacttg 11581 ccccacgcat ggtccttgac ctgctggaag tcggagggct tcgacacggt cacgtcgaag 11641 ctgaactcgt agacatggtc catgggcatc tcgcccttgt ccgccgaacg cgcggccgac 11701 accgtgttcg acgccttgtc ccaattgatt tcgaactcgc cggaaacgtc gcggttgccg 11761 tcgatcctgt cgatgagcct gtagttgtcc acggagtatt cgacgccgtt gggttcgatc 11821 acgtcgcgga aacgcatctc gtagccgccg cggccggtgc cgtacgtgat ggtggtgcgg 11881 ttcgtcatcc ggtcggcgct cacgccgtcc tcgatcttct tgaccggggg ttcgggcggc 11941 accgagctca ccttccagga ttcggtcgga tcgcggtccg cggtgtccac ggccgcctgc 12001 atgcggccct gcttgggtac ctggatgtcg atccagtacg tgccctcggc ccagtgttcc 12061 atgccgaaat ccttcggcga ggcgagatcg tcgagctggg tatccccatt gctcgggaag 12121 ctgatcggct tgctcacgct cttcgcgggc aggtaggggc cgttctcgta atggatgatc 12181 gcggtgccgt tcaacgtctc cctgatcgcg gaaccgccgt tgtcggcgtg gatgacgtcg 12241 ccgatcgggt cggtggagcc gacctgcatg tcggtcttct gcttgtggct ggtggtcacg 12301 ttcagcttgt aatcgaccgg cggctggttc tgcgccagca cgatcacgcg gaacgaggcg 12361 ttcgggttgg agtcgatcga ctcctgtgcc agcgagtcaa cgctgcgcgt gccgagcttg 12421 tccttccacg tggtcgaggt cgagtacttc tggccctgat acgtgtagtc gcccttcgcc 12481 tcggccttcc actgcgcctc ccaacggttc ttcgcgttcg agctcacata gctgccgttg 12541 aacgaaccat ccgccaagcg cacgtagccc accgccacca gacggcagtc cgcgttcccc 12601 tcacccgtat aggagcgttg gcactcatcg atcgcgtcgc tcaaagtctt gttcatgttc 12661 acgaactggt tctgcccgtt cgccagatcg gacgacagac gcaccttcgc gtcactcaac 12721 gccgtcttca tgccatccag cgtggccggc cacgaatcct tgtagatcca atgcacatcg 12781 gccgtctgcg tcggaccacc gcccgaaccg ccaccgtcct caccggaacc accgccaccg 12841 ttatcggcca acgctaccgg aaccagacag gccagcaacg ccgcggcggc ggtgatcgac 12901 gccaccgcac cggcgccctt cttcccgaac ctcatacgaa atcctttccc acatacgaca 12961 gaagcgcccc tctccgggaa agggaggaga cggggactcc agaacccgcc tcctcccggg 13021 tccctggaag aaaagcacgc ccgcaagccc gacggccggc cgccggaccc cgaacgcacc 13081 atcagcatca ccccgcgcca ggtggttctg cggcggacaa cacaacgtac atggcgtttt 13141 tgtggccaac ggccatttgc gaccattccg ctcatgagtt aaaataggtc gtgaaatatt 13201 ccattagtac ttgatagcag ggaagcggca ttgaaatatt catctgaaga ttttgtcaat 13261 ctggacgagg tccacgcact tgcggacgtt ctgaccccaa tcggaccggc actgtacacc 13321 gttcttgccg aggcgcgttc ggatctggaa accagatatc ccgatgatct gttctggccc 13381 catcagaacc gacagaatct ttcccgtctt gtcaaccaac gcacggctcg aatttgggaa 13441 caatatggtt ctgacgattg gacgcttttt gaccggagtg gtttccttca tctgagggaa 13501 aacgagaccg gcgtgaagct gattctccga aaggtggatc ctctgactca tggagttcct 13561 aagtcaaatg cgacccgtgc cagccgtgca tacttttcac agagccagtg catcccgaag 13621 ggacagttgc aagcagtgga tccaggcctg ttcgacgaag gaaagctgat tcccgatctt 13681 cacgatattg gcttggtgtg cacttgggat gagatgacgg atggaggtgt atccatcgtc 13741 gtttataaga cagaaggccc ggggcgatac ggcgaaaaga accactatct atttaaattc 13801 ccgctatttg atagcgttcg tggcgatgag caatatgagt tcattccact acaagaggat 13861 caggaaaatc ttctgccgaa tttgctggcc gatcagaccg atgtcgaaga tgtggataat 13921 acagactctt cgtcgtcgga gaaaaatgag aatgaggacg caggcatgaa ttccgacaat 13981 aaaggaaatg aagctaacta ggaatagcta gtcgtatata gcataaatag atagagagat 14041 actgcaatgt ccactttcaa tccagaaggg attgcactga agcagcgtct tgctttcaat 14101 ccagaaagga ttgcactggc acgacgcttg gagggcgtca ctcagaagga gttgtccact 14161 cgttctggac tatcccaggc aaagctcagc aagcttcaga atggcattat ttcctttaat 14221 gaatcagatg cggtgaaatt atccggcgct ctagactacc ccatttctta tttcgaggaa 14281 tctggaacgg ttatcccatt atccgaactt acatatcgaa aaacatccag atcatctatg 14341 ggtgaattga attcggtttc tacggagtac tcattactca tggatgtaat tcaaaaatta 14401 tgtcatgtgc tgaagatgaa aaaaaatcca gccgcatgga ttgatgaaat agctccacac 14461 gaacaatcgc tctccgaaga gaaaatagag agattggcta tccgaacacg tgaatgcctc 14521 ggattaaagc ctgatggtgc cgttccgaac gtaacccgcg caatcgagcg ggccggaatc 14581 attgtttctc cgatgagatc attgaatatg cgcggcgggg caaatttgac tagcgaggga 14641 gtgactgcgc cttcgtcaca gtggcatgcc atgtgtattg gatatttagg taatggtgca 14701 ttaggaggcg atcgtttacg ctttactaaa gcccatgaac ttggtcatct gatcttgcat 14761 cgttatcgta aacctgattc accgcaatta gtggagcgtg aagcccatat atttgctgga 14821 gcttttctga tttcgcaatt agatgctcgc ttggttctta aatccaattt atcgttgcgc 14881 gattttcttc caattaaggc aggatggggc atttccattg ctgcgcttat ctcacgttct 14941 cacaatttag gaatcatcga tcggcagagg tacacctccc tcaacataca actatcaggc 15001 aaaggatgga agaagcaaga acctgtaccc gtcggaatcg agaatccgct attgctgaaa 15061 cagatgatta catcggcata cggatttaag acagatcaag gactgaaaat agattctatt 15121 ggcttggcca gtgagttggg agctccattt agatatctag attactggtc cgatggatta 15181 gatgatgaag gtatgcactg gggtattgcc gccaatcgct ttgagcaaag gcccaatcgt 15241 atgattgctt aatccttggt tctgtcaaat caactttgac atcggcaaca cgtctggttg 15301 ttggcgttcc caggaacgcc aacaaccttg ggaaacgaat tgatcattca cgtcgattct 15361 aatttaacag aacctaattt ctacataggg ttcttccgtt tccctcttga gtaagagtgg 15421 aagaacccta ttctgatatg gttgaattga tttatactca aatggtaatt taatttgata 15481 tatacctact caacaaagaa atgaattcaa ttatcggaag caatgatttg tagattagat 15541 ttttaaggtg tagggccata ctcgtttctc tttactttaa tcattctaat gattttcagc 15601 aatgtgagta atgatataaa cgatgacggc gccgaagatg ccaatggcgg cgaggattgc 15661 cagtctggtt tcacggcgtt ccttggccgc catatcggcc tgccggttgg ccagggcttc 15721 ggcttcggcg gcgacgccgc tggcggcgat ggccgcgatg tgcgcgctca tctggtcttc 15781 gagcgtggaa tcctcgctcg tgccgtcgaa gggctcctcg ttttcgttgt ggttgtcgtt 15841 catggttctg ctccgttcct gattgttgga ttgtttgctt tcctgattgt tggcttgctt 15901 gattgcttgc ttgattgctt gcatgtccga ttgcctgcat gcaatcaagt ttgattgttt 15961 gattgtctgc atgcgggctt gtttgcttgt cagctttcgt tttgcccggc gaggatggac 16021 atgcgggcgg cgataagcgc gtggcgcgcg atctccagat agagctggtg gccctcgccg 16081 tcgccccaga accggtcgaa ctgttcggtc ggcatcatgc tggcggggtc gaacccgttc 16141 cacacgccgc cgcagaacac cttcgccgcc gcgttcacct cctcgtcgga cggcatgccc 16201 ggatgcccct ccgcggcgtc cgcggccgcg cgcatctgcg cgccgagcac gcgggcctgc 16261 aatggcgaga gcgtgtacgc cagtcccgcc gtggagcccg cggggaatcc cgtgttcacg 16321 ccgagggtga tgacgtgcgc ctcctcgccg atgctgatcc ggtcgccgag cacggagacc 16381 tccatcgaat agtccatagt gtctcctttc cgcagacgca tcggctttcg ggatcgcgtc 16441 tgcatgtttg actgcctgaa tgtttggttg ttggcttgtt tgcctgctgg attgtcggat 16501 tgcctgattg tttgattgtc tgacgggtta cggctcgtcg tcgctgtcga gtcggtcgag 16561 ctcgcgttcg atggcgtcgc gcaggagctg ctgcatgggc aggtcgtgcg cggcggccgt 16621 ggtcttgagc cgggtcttga gcgacacggg tatgcgcagt gagagc //