LOCUS       gnlProkkaJIOHCKLC_23   15339 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIOHCKLC_23.
ACCESSION   gnlProkkaJIOHCKLC_23
VERSION     gnlProkkaJIOHCKLC_23
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:51:00
            Original ID  :: gnl|Prokka|JIOHCKLC_23
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15339
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15339
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1285:5339]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1286..5339
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..15339
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15339
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(3..74)
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MIVEKKSHMTYNEKRLNHHFRKTH"
     CDS             complement(173..346)
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MNSVRRRHPELSPASPHKLRHTGATLARKSGVPLEIISEALTHSD
                     KQITKTYVNTKI"
     CDS             490..753
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MAHDFASWVSGDSMEPKYHNGSVALIRETGFDYDGAVYAVVCNSQ
                     TYIKRVYLEAEGLRLKYKDIFISYDEDPRVVRIIIGNFIPLK"
     CDS             1003..1107
                     /locus_tag="ctg23_4"
                     /transl_table=11
                     /translation="MENTEFSLELDVTEVSTEQGYVSGGVTSTGCCKD"
     CDS             1286..1564
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.8e-15, bitscore:
                     45.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLVANPQFFHNLTKEKIYKNSTFRNYVKRSITRATPFGLFSSIG
                     VGTFSDISYHQKIGENYTKKISVSGEWLSSICMMLENKDSVLLQLHI"
     CDS             1715..4078
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     577; E-value: 1.1e-174)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_6"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.3e-65, bitscore:
                     210.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.3e-19, bitscore:
                     59.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLELVLQSKSPDLEKQKILDYIRNLITNEFLFTNLRKVAISHKDL
                     DDLTNILKDINNQRKLTEDLLQIKNSIEQYAKLELGEGISQYTEICKKMSYIFNDKKQH
                     YLKVDLVNCCDSVLPKNLKKKMEDFVNFISKINLAKGYRNRELESFTEKFVEKYGEYVE
                     VPIKELLDGNLGLGLPKQTLGTHVKSSSSVEEQNFLSYLSKEVFKAVKNCKKEIDISNI
                     PLGLLYPNSDRFVANQLELYCEIKNFESQPVISVVPNTGSDMIGKSIGRFASYFPNSYI
                     SLDSQLDNVELIEFPRDSKNLNVMSAQNAHSKKLLLSYDDNDNTSIELDSVVVGVIKTE
                     YRYKLYFRDLRTGSIVNFVTTSMLNHKSNGVFSDLARFLLAVSLEWQDNPFSVFRIIEN
                     FDYLPYIPKIKYGNIILSEEKWVLSDIDKNDLSSIKQWKKDFDVPRLLYFHKADERLLV
                     DLENDLDTQWLLKQNVDKLYFTRFEKYDGKNCEFIFGFENYQSSINHYSMQEKSVRRLT
                     NNFYKNYVKTFSSDWIYFRLYGINSSILLELRERLLLFTDELLVEKLISDFHFVNYSDK
                     DNGSLRLRFKINNDDNFEDLRFRIAHWIDFLLESGFCNDVSFNLYEREIERYGGDNFIT
                     VCERMFSIDSFLTLKLFSKKLLNDKDLFSVLHSTFLYIRLLGIPLKRLLELLKGNLTQN
                     RYRKSFKKLFPNNTIVVKEFKEYFDYKNQFEIFNEVFREFPPIDGYFEGKNDIVYSLLH
                     MHMNRVGMFPYREKEYLYFIMYIAEPLNNYKEFT"
     CDS             4116..5339
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     308.8; E-value: 9.3e-94)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_7"
                     /sec_met_domain="LANC_like (E-value: 2.9e-52, bitscore:
                     168.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDSDIIDRLQRAYYTENRSYLSEYPSIIIYLSYRLINCDNKEYS
                     KLLYNRVNYYLQELLKSIKLNSTNNISLCYGFTGYVYALEFLSKNCKGYDKLLDTLETI
                     LLALTKDRLREIKSSNIVKEEYFDVIQGVSSVARYLLSKEESTSEQELLVKEILNYFAD
                     LIINEPTIYVEYMPNEKLRKRFPSGYINLGVAHGILGPLYVLALGFEKFNITKHIPSIE
                     KGLSYYENAFFTNTIGKIIGWNGRVSDYEENEEFRFNISWCYGSLGMARVLYNIAKIID
                     SQKLREMAMDVFTSSIDYLNSSEILNNGICHGRSGIMLLFNLMYLDTGKTQFKAISDNL
                     FKEIINDASNSEYIFVERDIYFRGVTFDEVIDYIDFGLLNGVSGIVITLMAQRTGNAYP
                     LDRMLFMQ"
     CDS             5363..6628
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 93.6; E-value: 2e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg23_8"
                     /transl_table=11
                     /translation="MRKILKNKLYLKVLVSDLISNFGDTLYFIALMTYVTEIKESNLAI
                     SIVNISETLPILFTIFFGIIADKTLNKVKMIIKTLWLRVILYLLVAVAMNFKPSIIVVI
                     IASLVNLVADTLGQFENGLFYPISNRIVKKSDREETMAFRQTVVSTMNIVNQSLGAFLI
                     TFFSFSHLAFINSLTFAISLLIMLAIRNQINSYYDETISTSKISQFDFKASFSEIISNL
                     KLSINHLFSIGNMKEALLVIPILNGSLAILIPLVVVNLSKDSNLTIVNSAITISLLGIS
                     TVSGGILGGTLILISKKFKSLSIGTLLKMNLTIVLLSFVAFYFQNIYLIILSSFLSSVL
                     VSALNPKMGTIIFNNIDETKLATIFGGMVTYFQIGDIVSRLLFSTLVIYLPYGYIALIY
                     IAVVFVAILYTLKSSNHIEREF"
     CDS             6856..7368
                     /locus_tag="ctg23_9"
                     /transl_table=11
                     /translation="MMFDDRLEIYSPGKLPNIVTVENIKHERFSRNPRIARTLTEFGWV
                     REMNEGVKRIYSEMESYFLHEPKYTEPGNKVVLTLENNILSRHLRVNDKMMKKYDEFND
                     LNDDEKAILHIMYNTGEKMTTALAARITNRGRNFASKLLKSLVNKEILEWHGTSKQDRN
                     QYYTLAE"
     CDS             complement(7705..8922)
                     /gene_functions="other (smcogs) SMCOG1077:phage integrase
                     family protein (Score: 110.6; E-value: 2.2e-33)"
                     /gene_kind="other"
                     /locus_tag="ctg23_10"
                     /transl_table=11
                     /translation="MSIKKTKNGTYQLRLYIPEDVQAKLGLGKLFERKYKTRREAKEVE
                     LKLSIDIKNAKSGKSHINIKNKGEIIFKKFYEDIWLEPYKAGQTTTTIKPPTKATVFQT
                     ENIFRLHILPILGKYSIEYPNNNKQLILSLLTPKANSYANFKVIRSYVNSVFDWAEELE
                     YIPSNKLRKTITRIKANKKILLKESKREEDLSLDKEELKLWLQAFDIDLEKGLIDLKDY
                     TLFYTTFFLSDRKSESYALQWKHINFSTGETLIEQALDRFGNIKPTKGRKKTLFKTPIE
                     LIELLANWKARQQEELKLFGLRQTQKQFVFTYNDRSNNINLPLHVDYLNYRMKSVRRRH
                     PELAPASPHKLRHAGVTLAKQAGYSLEAISEALTHSDKQITKTYVNTKDIVNRTVGDIA
                     FRSLKK"
     CDS             complement(8933..9205)
                     /locus_tag="ctg23_11"
                     /transl_table=11
                     /translation="MLVQLPEEQTQEIQQMIATLIKNEIHHFKEDIGADSTFLNKKQTY
                     NYLGISNNTLDIGIAMGLPYIRIGKSISFNKKSINQWMTRLEISA"
     CDS             complement(9267..10457)
                     /locus_tag="ctg23_12"
                     /transl_table=11
                     /translation="MIKESFPFDILNLFDTKGTPPFNFSNQYLNPNTKILDFNNATLYE
                     VDFDSLSPDTKAKLQEGAYKIGESRKVEGNLRAVIVDTTDQKNRVEDLTLRKMTNNNEN
                     QVPSDLIAQAQLKQIYNLLLDIKESQDYQIRWERNNSILAPFYSARTKVIEANNSKDFR
                     EKVKSLKDANTLFEESVSAIKSDIISNRDEIIKKISQPTYRQASLQTHADFLLQDIEIM
                     TKIVGMQIYIDLTLNNEGIAHDRLLSFQGSMELVSKQNIPYKTNYLKELAKKLLYVKEL
                     KWIKNNSIPKVSLLELIHNHYSYSKNNRDLFININTKLIEFHQDSNVNLSNTETAKIET
                     EKKMTLKTKKCKTCKKTISSPKTIPICDACRNKGKQLTVVGVALLVFFNKIINKKN"
     CDS             complement(10704..10961)
                     /locus_tag="ctg23_13"
                     /transl_table=11
                     /translation="MGNGGQWMNAPGYQTTHTPTEHSALSFSPGQAGADPTYGHIAFVE
                     QVKSDGSILISESNIKGLGVVSYRTFDAETAKQITYVIGH"
     CDS             complement(10937..11278)
                     /locus_tag="ctg23_14"
                     /transl_table=11
                     /translation="MVLSTRQQMVASTSPIPLALGKGVLKPCKNSIPISMSMEVHQKPL
                     NRRKEKPETEAVSQQGMSHKAIASPKKSIPQATQDCLILGDNVPGLSITEEKKSVLASE
                     SIWEMVANG"
     CDS             complement(11469..11657)
                     /locus_tag="ctg23_15"
                     /transl_table=11
                     /translation="MIEQDHRPVKRHNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTL
                     FGFSVCTEIKVLLGIPA"
     CDS             complement(11663..12157)
                     /locus_tag="ctg23_16"
                     /transl_table=11
                     /translation="MTINHFKGKQFQQDVIIVTVGYYLRYNLSYREVQEILYDRGINVS
                     HTTIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDEIYIKIKGKWHYLYRAIDADGLTLDI
                     WLRKKRDTQTAYAFLERLVKQFDEPKVVVTDKAPSITSAFKKLREYGAFIKGQNIVPLN
                     T"
     CDS             12307..13524
                     /locus_tag="ctg23_17"
                     /transl_table=11
                     /translation="MKQSQAKKHDNTMTNKILMRLIALVLGLLFLEILIIHSKNEQQKS
                     VSNQVQTARIMANGDLLYHDGLYMSALQADGSYDFTENFTYVKPWLKQADLVLGDFEGT
                     INPDYPLSGYPLFNAPQSVTAAISDAGYDVMDLAHNHILDSGLEGAFTTADAFKEVGID
                     PVGVYENPVRDKAPLFIKNVNGIKVAILSYAYGFNGLESNLTEKEIANHLSNLDEKRMK
                     VEIERAEKEADVTVIMPQMGVEYRLEPTDEQVKLYHKMIDWGADIIFGGHPHVVEPSEV
                     VKKDGQQKLIIYSMGNFISNQRIETMDGVDSAAWTERGVLMDVTLEKKNCQTTIKTAQA
                     HPTWVNRTPKGTISPEGYPLYTYQTYILEDFIKGGKYRNKLDEETKERIDTAYKEMNAH
                     VNLKWK"
     CDS             13845..14111
                     /locus_tag="ctg23_18"
                     /transl_table=11
                     /translation="MKAIITVVGKDKAGIVAGVATKIAELGLNIDDITQTILDEFFTMM
                     AVVSSEDKKDFTHLRAELEAFGESLNVKINIQSSAIFDAMHNL"
ORIGIN
        1 atatgagtct ttctaaaatg atggtttagt cgcttttcat tataggtcat atgggacttt
       61 ttttctacaa tcaaaaaggc tccataatct ccatagagga tttacccact acagaaatta
      121 tagagccatt tttttaagct tctatatgca atatctccag cagtttgatt tactatattt
      181 ttgtgttaac ataggtcttt gtaatttgtt tatcactatg agttaatgcc tcggaaataa
      241 tttctagggg aacgccagat tttcttgcaa gagtggcacc tgtgtgtctt aacttatgtg
      301 gtgaagcagg ggatagttct ggatgcctac gtctgacaga attcattcta tagttgaggt
      361 aatctgtatg aagtggaagg ttgatattat tggatcggtc attataggta aacacaaact
      421 gcttttgagt ctggtgtaaa ccaaatagtt ttaattcctt attatgaaac ggtttacttt
      481 acggaggagt tggcgcatga ctttgcctca tgggtgtctg gagattctat ggagccaaag
      541 tatcacaatg gttcagttgc tctcattcgt gaaacaggtt ttgactatga tggtgccgta
      601 tatgctgtgg tatgtaatag tcaaacatac attaagcgag tatatcttga agcagagggt
      661 ctacgtctaa agtataagga tatctttatt tcttatgacg aggatccacg agtagtgaga
      721 attattattg gaaattttat acctctcaaa taatacgttt ttctagtcct gaattgtcaa
      781 cttgtttgct tttttgataa tgattctagt tttcaaaaat gtaatgacat ctgttaagga
      841 tttcttatga aatatcttct gataacagag cttgtttgat agtacagacg gattttattt
      901 tataatactc cgaaacaaaa agaatgaatt ttctaaaaat tattgacaaa taaatttgct
      961 tttagtatta taaacacaac ttaaagaaga ggcagagtta tcatggaaaa tactgaattt
     1021 tcattggaac ttgatgtaac tgaagtttca acagaacaag gttatgtttc tggtggtgta
     1081 acatctacag gttgttgtaa agattagttt tataattgat tgaataaggc aggtatacga
     1141 ggtacttacc tttttttaca agagaattat gtttaagata aaagataatt acatttatag
     1201 gtaatgcgtt aatgattcaa gacttataga aaaacttagt gaaaataatc ttgaaatatt
     1261 ttttgataac aaagttttta aagaaatgtt gctagtggcg aaccctcaat ttttccataa
     1321 tttaactaaa gaaaaaatat ataaaaattc cacctttaga aactatgtaa aaagatcaat
     1381 tacaagagca acgccgtttg gattgtttag ttcaattggt gtaggaactt tttctgatat
     1441 ctcatatcat caaaagattg gagaaaatta tacgaaaaaa atctcggtta gtggagagtg
     1501 gctaagttcg atttgtatga tgttagaaaa taaagattct gtcttattac aactacatat
     1561 atagtggaac caaaaagtac ttgaattatc agataagtat caattaagta atgtcaatta
     1621 ctggggaatc tctgagataa gtaaggattt atttatcaag aaaactggac ttttagaatt
     1681 catacaaaaa ttaacgtata aatcggaagt cagtgtgtta gaactggtac ttcaaagtaa
     1741 atctcctgat ttagagaagc agaaaatttt agattatata cgtaatttga ttactaatga
     1801 atttttgttt acaaacttgc gaaaagttgc aataagccat aaagatttag atgatttaac
     1861 caacatttta aaggatatta ataaccaaag aaaattaacc gaggatttat tacaaataaa
     1921 aaatagtatt gagcagtatg caaaattaga gttgggagaa ggcatttctc aatatactga
     1981 aatttgtaaa aaaatgtcgt atatttttaa tgataaaaaa cagcattacc tgaaggtgga
     2041 tttagtaaat tgttgtgatt cggtgctgcc caaaaattta aaaaagaaaa tggaggattt
     2101 tgttaatttt atttcaaaaa ttaatctggc taaaggttat cgaaacagag aattagaatc
     2161 atttacagaa aaatttgttg aaaaatatgg agaatacgta gaagttccaa ttaaagaatt
     2221 attagatggt aatttaggac tgggtttacc aaaacaaact ttgggaactc atgtaaagtc
     2281 atcaagtagt gtagaagagc aaaatttttt gtcttatctg agtaaagaag tcttcaaagc
     2341 tgttaaaaat tgtaaaaaag agatagatat atcaaatata cctttaggat tgttataccc
     2401 aaattcggat agatttgttg caaatcagtt agagttatat tgtgaaatta agaattttga
     2461 atctcaacct gttatatcag ttgtcccaaa tacagggagt gacatgatag ggaagtctat
     2521 tggaaggttt gcctcctatt ttcctaattc ttatatctcg ttagattcac agttggataa
     2581 tgtagaatta atagaatttc caagagatag taagaattta aatgttatgt cggcacagaa
     2641 tgctcattct aaaaagttat tattatctta tgatgacaat gataacacat cgattgaatt
     2701 agattctgtg gtggtggggg ttataaaaac agaatatcga tataaattat attttaggga
     2761 tttacgaacc ggctcaattg ttaattttgt aacaacatca atgctaaatc ataaatcaaa
     2821 tggagtattt agcgatttag caagattttt gctagcggtt tctttagaat ggcaagataa
     2881 tccgttttca gtgtttagga taattgaaaa ttttgattat cttccctata ttcccaaaat
     2941 taaatatgga aatataattt taagtgaaga gaagtgggtt ttgtcagata tagataaaaa
     3001 tgatttatct tctattaaac agtggaaaaa agattttgat gtacctagac tactgtattt
     3061 tcataaagct gatgagcgtc tattggtcga tttagagaat gatttagata cacagtggct
     3121 tttaaaacaa aatgtggata aactgtattt tacacgtttt gaaaaatatg atggtaaaaa
     3181 ttgtgagttt atctttggat ttgaaaatta tcaaagtagt ataaatcatt attctatgca
     3241 ggaaaaatct gttagaagat tgacaaataa cttttataag aactatgtta aaacattttc
     3301 gagtgattgg atctatttta gattatatgg aattaattca tcaattctac ttgaactaag
     3361 agagcggctt cttttgttta cagacgagct attggttgaa aagctaatta gtgattttca
     3421 ttttgtaaat tatagcgata aggataatgg atcgcttcga ttacgattta aaataaataa
     3481 cgatgataat tttgaagatt taagatttcg aattgcacat tggatagact tcctactaga
     3541 aagtggtttt tgtaatgatg ttagttttaa tttatatgag agggaaattg agagatatgg
     3601 tggagataac tttataacag tttgtgagag gatgttttct attgacagtt ttcttaccct
     3661 aaagttattt tcgaagaaat tattaaatga taaagattta ttttctgttt tgcattcgac
     3721 atttttatat attcgattat tagggatccc attaaagcga ttacttgagt tgctgaaggg
     3781 gaatttgact caaaatagat atcgtaaaag ttttaaaaag ttattcccaa ataacacaat
     3841 agtagtaaag gaattcaaag aatattttga ttacaaaaat cagtttgaaa tttttaatga
     3901 agtatttaga gagttcccgc ctattgatgg atattttgaa ggtaaaaatg atatagtcta
     3961 tagtttactt catatgcata tgaatagagt aggcatgttt ccatatagag aaaaggaata
     4021 tctttatttt atcatgtata ttgcagagcc gttgaataat tataaggaat ttacttaaaa
     4081 agtatgaaga aattatctgt aaagtagata aactcgtgtt ggatagtgat attattgaca
     4141 gattgcagag agcatattat acagaaaata gaagttactt atcagaatat ccaagtataa
     4201 ttatatattt atcctatagg ttgataaatt gtgataataa ggagtattct aagcttctct
     4261 ataatagagt aaattattat ctacaagaat tgctaaagtc tattaaattg aatagcacta
     4321 ataatatttc actttgctat ggatttacgg gctatgtata tgccttggaa tttttatcta
     4381 aaaattgtaa aggatatgat aaattactag atacacttga gacaatttta ttagctttaa
     4441 caaaagatag gctacgtgaa ataaaaagct ctaatattgt taaagaagaa tactttgatg
     4501 taattcaagg tgtctctagt gtagctagat atttgcttag caaagaggaa tcaacttctg
     4561 aacaagagtt attagtaaaa gaaatattaa attactttgc agacctaata attaacgagc
     4621 caactattta tgtggaatat atgccaaatg aaaaattaag gaaaagattt cctagtggct
     4681 atattaatct aggtgtagct cacggtatat tgggaccact atacgtgttg gcgttaggat
     4741 ttgaaaaatt taatataaca aaacacatac cttcaataga aaagggcttg agttactatg
     4801 agaacgcctt ttttaccaat acaattggaa aaataattgg ttggaatggt agagtcagtg
     4861 attatgagga gaatgaggaa tttagattta atataagttg gtgctatggc agtcttggaa
     4921 tggcaagagt actatataat atagcgaaaa tcattgatag tcagaaatta cgagaaatgg
     4981 cgatggatgt atttacttca tctattgatt accttaatag cagtgagatt ttaaataatg
     5041 gaatttgtca tggacggtct ggaataatgc ttttgttcaa tttgatgtat ttagatacag
     5101 gaaagacaca atttaaagca atttctgata atttatttaa agaaattata aatgatgctt
     5161 ctaattctga gtatatattt gtggagcgtg acatatattt tagaggcgta acctttgatg
     5221 aagttattga ttatattgac tttggattgc taaatggtgt ttcagggata gttataactc
     5281 taatggcaca aaggactgga aatgcctacc cattggatag aatgctgttt atgcagtgaa
     5341 gtttttaagt taaaggagaa gtatgagaaa aatcttaaaa aacaaactat atctaaaagt
     5401 tctggtttcg gatttgatat caaattttgg agatacatta tattttatag ctctcatgac
     5461 ctatgttacg gagattaagg agagtaattt agctatttca atcgtaaata tatcggaaac
     5521 tctacctatt ttatttacaa tattttttgg tatcattgca gataaaacgc ttaataaagt
     5581 gaaaatgatt attaaaacgt tatggctacg ggtgattcta tatttattgg ttgctgtggc
     5641 tatgaatttt aaaccttcta ttatagtagt cataattgct agtctcgtta atcttgttgc
     5701 agatacattg ggacaatttg aaaatggtct tttttatcca atttctaatc gaatagtgaa
     5761 aaagtcagat agagaagaaa ctatggcgtt taggcagact gttgtttcta cgatgaatat
     5821 tgtaaatcaa tcattggggg cgtttttaat tacttttttt agtttttctc acttagcttt
     5881 tataaattct ctaacttttg ctattagtct gttaattatg ttagcaatca gaaatcaaat
     5941 taatagctat tatgacgaga cgatttcgac tagtaagata tctcaatttg actttaaagc
     6001 ttcattttct gagattattt caaatttaaa gctctcgatt aaccatctat ttagtatcgg
     6061 aaacatgaag gaagctttac ttgttatacc tattctcaat gggagtttgg caattctcat
     6121 tccattagtt gttgttaatc tttctaaaga ttctaatttg acaattgtta attctgcgat
     6181 tacgatctcg cttttaggaa ttagcactgt ttcaggagga atacttgggg gcactttaat
     6241 tctaattagt aaaaaattta aaagcctttc cataggcact ttgctaaaaa tgaatttaac
     6301 gattgtttta ctatcattcg ttgcttttta cttccaaaat atttatttaa ttatattatc
     6361 atcatttctt tcgagtgtat tagttagtgc attaaatcct aaaatgggga ctatcatatt
     6421 taataatatt gatgagacga agttggctac aatatttgga ggaatggtga catatttcca
     6481 aataggggat attgtgtcaa ggttattgtt ttctacatta gtgatttact taccgtatgg
     6541 ttatatcgca ttaatatata tagcagttgt ttttgtggca attttatata cattaaaaag
     6601 ttcaaatcac atagaaaggg aattttaaat tagttaaatg attatagttt tccaaatttt
     6661 ctactatgaa aacctatttt caagattgag tactaaagtt cgagattttg ttcgtactca
     6721 gcttagagaa tttcaatatt tggatgatgg gcaatttaaa acattaccag agtatccaga
     6781 atttgcttgg tttgaaggga tgtaaatgcg gtaactcata gaaattgctc catttttggc
     6841 gattatatcc gaattatgat gtttgatgat cgattagaaa tttatagtcc aggtaagctt
     6901 cctaatatcg taacggttga aaatattaag cacgaacgtt tttctcgtaa tcctcgtatt
     6961 gctagaactt taacagaatt tggatgggta cgagaaatga atgagggagt gaagcgaatc
     7021 tattctgaga tggaatctta tttcttgcat gaacctaaat acacagagcc aggaaataaa
     7081 gttgttttaa ctcttgaaaa taatattttg agccgacatt tgagagttaa tgataagatg
     7141 atgaaaaaat atgacgaatt caatgattta aatgacgatg agaaagcaat tttacatatc
     7201 atgtataata ccggagagaa aatgactact gctttggccg ctagaataac aaataggggt
     7261 agaaattttg caagtaaatt attaaagagt cttgtaaata aagagatcct ggaatggcat
     7321 ggcacaagta agcaagatag aaatcagtac tatactttgg cagaatagcg gatctattta
     7381 taactggagt gcagaagagt gcagtagttc ggagtaaaac gcagtaagtg aatttcccct
     7441 gttttcctca aaaaatctca aactttttga aattctggac aaaagaaaag gcctagttgc
     7501 ctgtagtttc tacctattaa gttatattga aattcattgg tttaaaacca gatcttaaga
     7561 aagctcgtaa agcttcacaa ttctcaaaac gttaatcaat acgattatat caatgtttca
     7621 agacattcaa gagttatctc ttgggtgtct ttttttattc aaaattcgat agtttccacc
     7681 aaagtttcca ccaattttcc accattattt tttcaagcta cgaaatgcaa tatcgcctac
     7741 tgtccgatta actatatctt ttgtatttac ataagtcttt gtaatttgct tatcactatg
     7801 agttagagct tctgaaatag cttcaagaga ataacctgct tgtttggcaa gagtaacacc
     7861 tgcatgtctt agtttgtgtg gtgatgctgg tgcaagttct ggatgtctcc gtctgactga
     7921 cttcattcta taatttagat aatccacgtg aagaggtaaa ttaatgttgt ttgaacgatc
     7981 attataggtg aatacaaact gcttttgagt ttgacgcaat ccaaataatt ttaactcctc
     8041 ttgttgtctt gctttccaat tagctaatag ctcaattaat tcaataggtg ttttaaaaag
     8101 ggtcttctta cgacctttgg tgggttttat atttccgaaa cgatctaaag cttgttctat
     8161 cagtgtttct ccagtagaga aattgatgtg tttccattga agagcataac tttctgattt
     8221 tctatcggat aaaaagaatg tcgtataaaa gagagtgtag tcttttaaat caataagtcc
     8281 tttctctaag tctatgtcaa aagcttgtaa ccataatttc agctcttctt tatcgagaga
     8341 taaatcttcc tctcgtttgc tttctttaag gagaatcttt ttattagctt taattctagt
     8401 aattgttttg cggagtttat ttgatggaat atattctagt tcctcagccc aatcgaaaac
     8461 agaattaaca tagctcctaa ttactttgaa attagcatag ctatttgctt tgggagtaag
     8521 taatgaaaga ataagttgtt tattattatt tgggtattcg atagaatatt tacccagaat
     8581 gggtaaaatg tgtagcctga atatattttc tgtttggaaa actgttgctt ttgtgggtgg
     8641 ttttattgtt gttgtggttt gacctgcttt gtatggttcg agccaaatat cttcataaaa
     8701 ttttttgaat atgatttctc ctttattttt tatgtttata tggctttttc cagacttagc
     8761 atttttaatg tcgatagaaa gttttaattc tacttctttg gcttctcgtc tggttttata
     8821 ttttctttca aaaagtttac ctaaacccaa ttttgcttga acatcttctg gaatgtaaag
     8881 tcgtaattga tatgttccat tttttgtttt cttaatagac atatttacct ccttatgcgc
     8941 tgatttctaa tcttgtcatc cattgattga tacttttctt gttgaaacta atagattttc
     9001 cgattcggat atagggtaat cccattgcaa tcccaatatc aagtgtatta ttagagatac
     9061 ctaggtagtt gtaagtctgt tttttgttta gaaaagtgct gtcagcccca atatcctctt
     9121 taaaatgatg aatttcattc tttattagtg ttgcaatcat ttgctgaatt tcttgagttt
     9181 gttcttctgg caattgtact agcatatatt attctcctct taaaaataaa aaagaagagt
     9241 aaaatactct cctgctgtta aaaagattaa ttcttcttat ttattatttt gttgaaaaaa
     9301 actagcaaag cgaccccgac cactgtcaat tgtttgccct tattacgaca tgcatcacaa
     9361 attggtattg ttttaggtga tgagattgtt tttttacaag ttttacactt cttcgttttt
     9421 agtgtcattt ttttctccgt ttcgattttt gctgtttcgg tattgcttaa gttaacgtta
     9481 ctatcttggt ggaattcaat taatttagta ttaatattaa taaataagtc cctattgttt
     9541 tttgagtagc tgtaatgatt atgaattaat tctaacaaac ttacttttgg gatactatta
     9601 ttctttatcc attttaattc ttttacataa agaagttttt ttgctagttc tttcaaataa
     9661 tttgttttgt atggaatatt ttgtttagaa actaattcca tcgaaccttg aaaagatagt
     9721 agccgatcat gggctatccc ctcattattt agtgttaaat cgatataaat ttgcatacca
     9781 acaattttag tcataatttc tatgtcttga agtaaaaaat cagcatgtgt ttgtaaagag
     9841 gcttgacggt atgttggttg gctgattttc ttaataattt catctctatt tgaaattata
     9901 tcagatttaa tagcacttac tgattcttca aataatgtat ttgcatcctt tagtgactta
     9961 actttttctc tgaaatcttt gctattgttg gcttctataa cttttgtacg agctgaataa
    10021 aatggagcta gtatactatt atttctttcc catctaatct gataatcttg actttctttg
    10081 atatctaaca gtaagttata gatttgttta agttgagctt gagcgattag atcactagga
    10141 acttgatttt cgttgttatt agtcattttc cttaatgtca aatcttcaac acgattcttc
    10201 tgatcggttg tgtctacaat tacagcccta agatttcctt ctacttttct agattcccca
    10261 attttataag cgccctcttg aagtttcgct ttggtgtcag gagatagact gtcaaagtca
    10321 acctcatata gagtagcatt attgaaatct agtattttag tgttaggatt aagatattgg
    10381 tttgaaaagt tgaatggagg ggttccttta gtatcaaata agtttaagat atcaaatggg
    10441 aaactttctt taatcatgtt ggggagagct tgttcaaaag gactacttat ttcaaagata
    10501 tctgttgttt tgatatctgt ctcattttta aataaatcaa aagattgtaa gtttttttga
    10561 ttgattcttc tttttgcttt tctgatttag caacttcgtt cattagatca cctagtcatt
    10621 tttgtattaa ttataacatt tagtattgat tttaaacgta tctaaattaa taatactaaa
    10681 aattaatatt attaaaacca tcatcagtgt ccaatgacat aagtaatttg ttttgctgtt
    10741 tctgcatcaa aagtgcggta gctaacgact cctagtcctt tgatatttga ttcagagatg
    10801 aggatggagc catctgattt gacttgttcc acaaaggcga tgtggccata agttggatct
    10861 gctccagctt gccctgggct aaaagataga gcggagtgtt cggttggggt atgagttgtc
    10921 tgataccctg gggcattcat ccattggcca ccatttccca tatactttcc gaagctaaca
    10981 ccgacttctt ttcctcggtt atagacaaac caggtacatt gtccccaagg ataagacagt
    11041 cctgtgtggc ttgaggtatt gatttctttg gtgaggctat agccttgtgg gacatcccct
    11101 gttgtgacac cgcctccgtc tctggttttt cctttcgtct gttcaggggc ttttggtgta
    11161 cctccatgct catcgatata ggtatcgagt ttttgcatgg tttcagcacg ccctttccta
    11221 gagccagagg tatcggtgaa gtagacgcca ccatctgttg acgtgttgag agaaccactc
    11281 gcaaattttt gcgctttgtc atcttggact tttaaggttt catttttatt gccaatgatg
    11341 gtctgctttg tgagtccaac aacggctact tcatcgttaa aattattggc attttctgga
    11401 ttagagtcaa atgcggttct gttgcaaagt tttaaataaa gaataaaatc ccttacggta
    11461 tctatgattt aagctgggat tcccaataat accttgattt cagtacagac cgaaaacccg
    11521 aagagagtgc cttcttttcg agttttctta tataatcctc ggatggcttc catgccttta
    11581 atcgtggtag aggcagtgcg taaacttcga tagaatttat tgtgtctctt tactggacga
    11641 tggtcttgtt caatcaaatt attcaggtat ttaatggtac aatgttctgt cccttgataa
    11701 aagccccgta ttctcttagt ttcttaaagg cacttgtaat agagggggct ttatctgtga
    11761 ctacaacctt cggttcatca aactgcttaa ctaaccgctc aagaaaagca taggctgttt
    11821 gtgtgtcccg ttttttacgt aaccaaatat ccaaggttaa accatctgca tcgatggctc
    11881 gatacaaata atgccatttt cctttaattt tgatgtatat ttcatccatt ttccatgaat
    11941 aaaaggattt tttatttttc tttttccaaa tttgatagag tagtttgcca tattcttgca
    12001 cccaacgata aatcgtcgta tgagaaacgt taatgccacg atcatataag atttcttgaa
    12061 cttcacgata gctaaggtta taacgaagat aatagcccac ggttacaata atcacatcct
    12121 gctgaaattg ctttccttta aaatgattta tcgtcattcc tcctgctatc tttttctatt
    12181 attctacctg atttgatagt agatttaaaa ctttgcaaca gaaccgatgt aaccgtttat
    12241 taatcttttt tatcatctat ggataacatt tttttgttac actaggagta tgaaaaagga
    12301 gatatgatga aacagagcca agctaaaaag catgacaata cgatgactaa taagattttg
    12361 atgaggttga ttgctcttgt cttaggtttg ctttttcttg aaattttgat tattcatagt
    12421 aaaaatgagc agcaaaagag tgtttcaaat caagtacaga cagcacgtat catggctaat
    12481 ggggacttgc tttatcatga cggtctctat atgagtgcct tgcaggcaga tggcagttat
    12541 gattttactg aaaattttac atatgtgaag ccatggttaa agcaggctga tttggtcttg
    12601 ggtgattttg agggaactat caatcctgat tatcctttgt caggctaccc tctgtttaat
    12661 gctcctcaat cagtgacggc agctattagt gatgccggct atgatgttat ggatttggcc
    12721 cataatcata ttttggactc tggtttagag ggagctttta caacagccga tgcatttaaa
    12781 gaggtgggca ttgaccctgt tggtgtttat gaaaatcctg tgcgtgataa ggcgcctctg
    12841 tttatcaaga atgttaatgg catcaaggtg gcaatacttt cttatgccta tggtttcaat
    12901 ggcttggagt caaatctgac cgaaaaagag attgcgaatc atttgtcgaa tcttgatgaa
    12961 aaacggatga aagtagagat tgagcgtgct gaaaaagagg ctgacgttac ggttattatg
    13021 ccacagatgg gcgtggaata tcgtttggaa ccgacagatg aacaggtaaa gctttaccat
    13081 aagatgattg attggggtgc tgatattatc tttgggggcc accctcatgt ggttgagccg
    13141 tctgaagtgg ttaaaaagga tggacagcaa aaactcatta tttactcaat ggggaatttc
    13201 atctctaacc agcgcataga gactatggat ggtgtggata gtgcagcatg gacagagagg
    13261 ggcgtcttaa tggatgtcac tcttgagaaa aagaattgtc aaaccacgat taagacagct
    13321 caagcgcatc caacctgggt taaccgcaca cccaagggaa caatttcgcc agagggatat
    13381 cctttatata cttatcaaac ctatatttta gaggatttca ttaaaggtgg aaaatacaga
    13441 aataaactag atgaagaaac taaagagcgt atagatactg cctataaaga aatgaatgct
    13501 catgttaatc taaaatggaa ataaagctaa gatatcgcta aaatttggcg atatttttct
    13561 ttatcgacaa gttaccaaca gacttatcca caggtgtgga taagtctgtt ctcagtgtta
    13621 aaccttgatt tttcaaggtt ttattagaat tgtattgttt tacttgttaa caagtttatc
    13681 cacaagttgt tgaattgata gagactgaat tttataaacg atactggtta aatgttgtag
    13741 aaacattcgt ttttttcaat aaaaaaggtg taatttctat aaaaaatagc gtttttaatc
    13801 aaaatatgct aaaattatat aaaataaaat gatggaggct tctcatgaaa gcgattatta
    13861 cagttgtagg taaggataaa gcgggtattg ttgcaggtgt tgcgactaag atcgcagaac
    13921 ttggtttgaa tattgatgat atcactcaaa caatccttga tgaattcttt accatgatgg
    13981 cggttgtatc atcggaagat aagaaagatt ttacacacct acgtgctgaa ttagaagctt
    14041 ttggtgaatc attaaacgtc aaaatcaata tccaaagctc agcgattttt gatgctatgc
    14101 acaacttata agataggggt agttgaaaat ggatattaaa caggttacag aaaccattgc
    14161 tatgattgag gagcagaact ttgatgttcg tactatcacc atgggaattt cacttctaga
    14221 ctgtatcgat tcagatattg ataaggcagc agaaaaggta tacaacaaga ttgtttctaa
    14281 ggctaagaac ttggtagctg ttggtgacga aattgcggct gaacttggta ttccgattgt
    14341 taataaacgt gtttctgtta ctccgatttc aattatcggt gcggcgacag atgcgacaga
    14401 ttatgtaccg tttgctaggg cactagaccg tgcagctaag gaaattggca ttaactttat
    14461 tggtggtttc tctgcattag ttcaaaaggg ctaccaaaaa ggtgatgaga ttcttattga
    14521 ttctatccca cgtgcgcttg ctgagactga ttttgtctgc tcatctgtta atattggttc
    14581 aacaaaaact ggtattaaca tgacagcggt acgtgatatg ggacgtatca ttaaagaggc
    14641 ttctgaggca gatccaatgg gtccaggtaa attggttgtc tttgctaatg cggttgaaga
    14701 taatccattt atggcaggtg ccttccacgg tgttggtgag gctgacgttg taatcaatgt
    14761 tggggtttca ggtcctggtg ttgtgcaacg tgctgttgag aaggtttcag gtgaaagttt
    14821 tgatgtttta gctgaaacag ttaagaaaac tgcctttaaa atcacacgtg tagggcagtt
    14881 ggttggtcaa atggctagcg aacgtctagg tgtcgagttt ggtattgtag acttgtctct
    14941 tgcaccaact ccagcagtag gtgattcggt agctcgtgta cttgaagcca tggggcttga
    15001 agttgttggt acgcatggta ctactgcggc tctagctctt cttaatgacc aagttaaaaa
    15061 aggtggtatc atggcatgta accaggtcgg tggtttgtca ggtgccttta tcccagtttc
    15121 tgaagatgaa ggaatgattg cagcagttca atctgggcat atcaaccttg aaaaattgga
    15181 agccatgacg gctatctgtt ctgttggtct agacatgatt gccattcctg ctgatacgcc
    15241 agatacaaca attgcggcca tgattgccga tgaagcggct attggtgtca ttaatcagaa
    15301 aacaacagct gttcgtatta ttccttatgg taaggaagg
//
