LOCUS       gnlProkkaLFBKNOKG_27   17170 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFBKNOKG_27.
ACCESSION   gnlProkkaLFBKNOKG_27
VERSION     gnlProkkaLFBKNOKG_27
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:35:54
            Original ID  :: gnl|Prokka|LFBKNOKG_27
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17170
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17170
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4745:7170]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4746..7170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17170
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17170
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             3..164
                     /locus_tag="ctg27_1"
                     /transl_table=11
                     /translation="MDTDRSMKVIELLRDLAHKRNKIIIVVTHDLRLKDMADKVYQIID
                     GKMTILEK"
     CDS             294..407
                     /locus_tag="ctg27_2"
                     /transl_table=11
                     /translation="MPTKIWLKPEQLDLYIKHLERFRDLYSKLDCSGIVNL"
     CDS             636..737
                     /locus_tag="ctg27_3"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             907..1176
                     /locus_tag="ctg27_4"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1336..1635
                     /locus_tag="ctg27_5"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1735..2646)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 96.3; E-value: 2.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg27_6"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALFITSTTKFELI
                     TFGIPLVGQEILDSVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2876..2965)
                     /locus_tag="ctg27_7"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2962..3564)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_8"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.6e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALELDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3658..4749)
                     /locus_tag="ctg27_9"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4746..6065)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_10"
                     /sec_met_domain="Streptide_RRE (E-value: 1e-24, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.1e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.5e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6135..6227)
                     /locus_tag="ctg27_11"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6310..7170)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg27_12"
                     /sec_met_domain="TIGR01716 (E-value: 5.2e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7410..8222)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.8; E-value: 2.9e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg27_13"
                     /transl_table=11
                     /translation="MLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIFTEHKGNYG
                     YRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAENLIQRQFE
                     ASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQVKAMLEQAF
                     TEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESFFGILKSEM
                     FYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8240..8806)
                     /locus_tag="ctg27_14"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8985..9143)
                     /locus_tag="ctg27_15"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9155..9286)
                     /locus_tag="ctg27_16"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9479..9808)
                     /locus_tag="ctg27_17"
                     /transl_table=11
                     /translation="MAAAKLVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQ
                     PYMTESAYSQELTSQNDAMNQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSD
                     LKNAN"
     CDS             complement(10208..13387)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 496.3; E-value: 3.3e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg27_18"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDHFQKSLEERLRQSNKDMEKRQAQLDGHFASQVWSE
                     EELSVLEQTPASEKLTRLEEFLSQRQENVTKQKSILKAAHEDLAQLQKSLQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELTVQSKDFLQKEEELETWKENIIYAQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLDSLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLIIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVAKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13384..14592)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.8; E-value: 6.5e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg27_19"
                     /sec_met_domain="Metallophos_2 (E-value: 4.6e-10, bitscore:
                     31.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFKTLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 cattagatac agatagatcc atgaaagtaa tcgagttact cagagattta gcgcacaaaa
       61 gaaataaaat tattattgta gttactcatg acttaaggtt aaaagatatg gcagacaaag
      121 tttatcaaat aattgacggt aaaatgacaa tcctggagaa gtaatttaat ttatgactaa
      181 aaatcagcaa aaatataatt atgactaagg aatattttat taactaaatg ttgagatagc
      241 acaaggaaat atttgtgcta tcttttttat ttattaggaa aagagaaaaa attatgccaa
      301 cgaaaatatg gttaaaacca gaacaattag atttgtatat taaacattta gaacgattta
      361 gagacttata tagtaaacta gactgttctg gtatagtaaa tttgtaacac tcctacctaa
      421 taagttaaac tattcattag aataggagac ataacatgaa acactatcca gacgaaacac
      481 gataaaaaat tgttcgactg cacattcaag acggatgaac attaaaaagc ttagctgctg
      541 aatatggcgt atcccaagcc tcaatctcta attgggtaag acattatcgc aaagaatgcc
      601 aaactaataa taaagaaaaa tcacagcttg aactcatgga ggaggttcgt aaattacgtc
      661 aagaaaaggc agagcttgaa aaggaaaatg atttcttaaa aaaagcagcg gcattctttg
      721 caaaggaaat cgattagagg catatcgttt tattgataac tataaagaag attttggttt
      781 gcgttggttg ttcttgcata tgaatattca tcccaatgct tattataatt atcttaaaaa
      841 gacaaggact aactatcatc gtcaaaagaa agctattctt aatactattc gagatatcta
      901 ccatgagtgc aatggaaaga agtaaatcaa ttcttcgaaa cagaaagcat caaactttct
      961 gatatagagc cttcgaaagt tagttatagg gaggtacaaa ggaatcaaat caataccact
     1021 atttataatg aaaaaggtaa tataaaggat attgatacta gcattataag agatatgtac
     1081 gataaaagca aacctacttt aaaacaggga gcctatatat ccgctatagc agcttctcta
     1141 gaaggggggt actgcattta taacagcaat aattaaaaaa agcgcttagg gaaaactatt
     1201 agtgagttta caaaagacga ttgtcttgaa atttctaaag atagtggaat tggagctata
     1261 aaaggaagta ctcgaggcat tacgatatac gccctaacga attacacagc tactcctgca
     1321 gcagtagcaa gttcattgtg cactgcttca tttggtatcg ctaaagaagc atacaaattc
     1381 cgtaaaaact taatcacaaa agaagaattt ttactaaatt cgcaaatatt atgtgttgaa
     1441 gtatcagtta gtgcattatc ctcaatatta ggacatgctg taattccaat acctatttta
     1501 ggatccgtta ttggaaataa tataggaact ttcctatatg aaatcgctaa agataatctc
     1561 acaatgaaag agaaattact gatagcagat tatttcaaag agatacaaga atataactat
     1621 tttttagata attaatttga attatataat catcaacttc agagagatta agaattacta
     1681 taaactttta gggaaggcat tttctcctga ctataatatc gcttttcagg gatcttatga
     1741 atttttaaat atgtttttta aaaatacgtt aacctctcct attttctctg cttcaggtaa
     1801 atagatagaa acggttgtcg aataaacaaa agaaggtaca ctcacaattg aaagcaattg
     1861 actaataact gcataaatag ccaacaattc tactcctaat ctcgacatca aggcatcaaa
     1921 caccataata aacaaaacac tatccagaat ttcttgacca accaaaggaa taccaaatgt
     1981 tattaattca aatttagttg tagatgtaat gaataaagcc ttcaaaatca ttggataaac
     2041 cataaacaag taactaagcg atatgaaagc taaggataca atcgttgata tggctgctcc
     2101 cttaattccg atttgtggta ccagtacata atttaacaca acatctatta atgaactgat
     2161 aagtccaacc cacataattg gttttgtttt cttttgaact cttaataaat ttgtcagcga
     2221 aaagtttaat aatgtcaatc cgatatatgg agacatgaag actaaataaa tggtggataa
     2281 ggacaatagt tgccctttaa atccatagag ctgcttcaag attacatttc caaaaataat
     2341 gacaaaaacc gcaaaggcaa ctccgataat taaatctaag gttagatttg atttcaataa
     2401 atcatcaaac ctgttagttt gccgattaga gtacgcctta gagcttttaa tattaaatga
     2461 caaactgaat gctcctaaaa gtccaccaaa agcaaataag agattctgaa taatggaaat
     2521 tcctgacaga gcaattgagg aattgttcac agcaaaatgc aatgctatct gcccaataat
     2581 tacttgacca atatttgtta aaactaaggg aaaggcaaat ttgttaattt cttttgaatc
     2641 tatcattttt cctctctaaa aggcttcaaa tgtaagtaaa gatcagattt aactaaattt
     2701 gcataaataa tatgcaaaat aggagtttct tctaaaaatg aaataattgc ctgcttacaa
     2761 tcattagcag atacctcata atcttgctgt aatagttcta caatcttgtc taaagaaaaa
     2821 tttttagaaa tgcaataaag tatttctgct cctatttcat caaatgaata gtactctaat
     2881 caagtagatc gtatcctatg tattcatctg ctactttatt tacaatgaaa tctctcttac
     2941 ctcttatcac aaaatgttct ttcatacgac tactccacct cctttttgtt cataaaagca
     3001 ggctaaatca gagcccagta acgttccatc taattccaag gcactgcatc gacatccccc
     3061 accacaccat ggtaggggac attctgaaca tttcccagaa atatcatcaa atgtaattga
     3121 tcttagttta ttaaatacag cagaatggtg ccaaatttcg ctaaactttt gttctttaac
     3181 atttccagca actaattcat ctataccatt catcaagtca cacccgtata catctccttt
     3241 atgattaatt gaacatgctc taactccagc ttgacaagat atttcccttg gcttatcaaa
     3301 atttatatct actttttgat gccaaacatt ttctaataaa tctgatctat tataaaatgc
     3361 aagcggaaaa taatgtgtca aaaaaacatc actttcatta ggaggaacaa ttttaaattt
     3421 aactttgaac tctcctttag aaatccgctc tgttaaatca agaaaaacag gataccattg
     3481 ttttttatct gctaaaatac taccgtcatt agccctacca gtaggacaaa taaccataac
     3541 tgacatatac tcaataccaa gcatatcatt caatcttata ctctaaagaa aatatctgct
     3601 aaatttgcaa acaattgtgc tatcaataat ttggcaaatg aattagaaat acaactttta
     3661 agttcttttc tctctgttag aaaatgaata agatactaag caacaaagag ctactatacc
     3721 aaatattaaa taattgctcc taatactaaa gttatcagca aaaataccag ctaggaaatc
     3781 agctaacata aaactaatcg aaataaacaa attatatact gaccatgata ctgctctatt
     3841 tttttctatt gacatattaa atttataata aaaatgatta ttgtagttgg aattaagaac
     3901 acgcattaat aaaaggatta taatttggat gattagatta gtttgaaaaa acatgagtat
     3961 agctaatact ggtaacatca agcttacttc aaacttaatt tttagataac tccccaaagc
     4021 catagatata ttaaacataa atagtataat tcccagcata tctagtgaaa gtccctgttc
     4081 atttaagaat atccctgcat aagaattgct aatcataatt agagttgaga atgctactcc
     4141 taatattatt aataaccatg gaatattttg aatattatcg aggctaaaaa atttttgttt
     4201 attattttgt tcctttttaa tctcgggtaa tcctattaaa tataataaac tgaaaattac
     4261 aaatacaatg gatataataa taggataaat ataattccta tgcaataaag gtggagatat
     4321 aatcgtaata atagcaataa aaatatattt taatgtgttg agatttttca aaaatgattt
     4381 atatacaact tcgtcatcaa ttatttcaaa attataagaa ataagaactc ctgaagataa
     4441 tgattctgac aatccaaaaa atatcgctga aatatatatt atatttgatt ttccaaacaa
     4501 taggccccat aatgctaaaa ttaataataa atttgaaata gccaaaattt tcttgtaacc
     4561 aatcttactt gaaatataac ttaaaggaat atcaaaaact gagccacata gctcagtaat
     4621 aactgataaa gtagctattt ctgtgaacga aaaacctaag tgctttaata gtaaaattcc
     4681 tacaaagtag tacggtaatc cagatagaaa catattcatt ccgtataaat taaaaatctt
     4741 cttactcata agttacaaac tgggtctcta aaatattttg gactcttctc cttaatcaag
     4801 ttaacatagc agccaccctc gcaaattttt aacaatccac aagataaaca cttagaattc
     4861 ttcgttctaa aagaacgaat ccctccatac aacggatcat cataccaaac atctaacaaa
     4921 tctttttcaa aggcattctg cttagtttga ttaactccta aaaaagcaat gcaaggcaag
     4981 atatccccat tagacattat ttccatctta gtatattttg cacgacatcc ataatacatt
     5041 tcgccaaact ctgaaaattc aattgaatta tttatcaact ccggataagc ggtgaaaaga
     5101 tgacatccct cagtagcaaa atttaaatta gcttcccgtt gagttatata atctgtaaca
     5161 tactcattca accttctcaa atcagctaaa tcgtattttt tctttatttt cgtatatcct
     5221 gttacctcag aataattagc tactgaaaat ctatctattt tattctctat acaaaaatca
     5281 accaattcta taatctgctc atagctttgc tttgtataca ctgcattaat tctacatttt
     5341 tttccaacct ctttaaagta cttcgctaat ttaatttgtc tatcaggtct cacccccatt
     5401 aattcaaaat ttaatttagg atctaaagtc tgcaaagata aaaccggtgt aatatattta
     5461 gatttagcta gaatttccac tgtacttttc tttattaatt gggcattagt tgttatagta
     5521 gtctttatct tcagttcttc acaagctatc aacaaattat caatatcaaa atatctagtc
     5581 ggttcccctc ctaaaattga aacacttaac actccattat cttttgcttg gcgcaaaatt
     5641 ctttcccaat ctttagcagg tttggcattt ctatcttcac gatttgctaa aaaacaaaaa
     5701 ccacatttta aatcacagta catactgggg tatattacta gttcaagcgg aaaactcaat
     5761 atgttatgtt tttttaattt tgctacatgc tttctcgcat tttgaagagt ctcgtcagga
     5821 tttttcgatg atccctcaat attattatca gaatagatat ttaataagag tactcgctct
     5881 agtttccctg cttttatttc tttcttaaaa aaggacgtag caatttcaaa accatgattt
     5941 tgaaccaaat aaagaaaata agcttcactc tcatctaact caattcggtc aaaagttact
     6001 ttatttatca aaattccacc aaacttttct agtctaaata aaaaatcttc tgaaattgtc
     6061 atcatattga atacctttct aaaaaagcag aggaaaatat agcctcttct taacttatgg
     6121 gataaattac tttatcactc ccagccgtca ccttttgcca tcaccttcca gccgtcacct
     6181 tttgccattg aactagactc aaggactttt tcaagctctt tagacatatt tggtactcct
     6241 ttcgaatatg atactgtgat tatatttctt ttcaacactt acaataaaat attcccatat
     6301 ttgcattttc taactactag ctaaaatttt ttctaaatgt ccttcataag tctttgctaa
     6361 gtgatgactt cctgctaatt tcatcgctcc aacacacttc ttcatttcaa taattgcttt
     6421 cacatttcca tcctctttat attgataaag attttgtgca tacttaaaga ctaaacgttc
     6481 atatacttct gtctcaataa aaaagcattg atttagctgc ttttcaaaat ataaagcatc
     6541 cataaatttt tctctttcaa cacatgtaat atatccattt aaaagcatcg ttgaaattaa
     6601 tcgtctgtta tttggaattt ctttgtaaaa atcagaacgc ctaaacattt ctcttgctaa
     6661 gaccatgaaa acatcatgat ttaatacatc taaagtattc gagaaaatca ataactcata
     6721 gtacccccag tattctacac taaagagata atctgttaaa tatgtcaaat catcctttgt
     6781 atagtaagtt tctcctgata aatcctgtag acgaattttc aataaaataa tattgatttg
     6841 atgaaatttt tctcgcctat cttccagttc catctgagaa taaagtaatt ttttcatacc
     6901 ttctacgtca cgtgttgaca caaaatgacg tactttcgat aacagttcgt ttaactcatc
     6961 tctatgaaaa tcatggaccg catacataaa ttcatctatt ggcatattga tttcatctaa
     7021 aataaacatg aactttgaaa tcgttaaatc tgtttctcct ttctcaaatc gagagagctg
     7081 agacgttgat ataccagcct ttgcgacgtc ttttaatcgt aatcctctcg attctcgaaa
     7141 ctttttaaaa atttctccaa attttttcat actacacctc catcacgcat atatgggaat
     7201 aattttcatt tgctttcatc atatcataca ataaagaaaa acaaaagtga ggattatcac
     7261 atgaaaaagc aaattttact aacacttctt cttgtcgtat ttgaaggcat tatcgttatc
     7321 gtcgtgggat aaagagtctg ggacaaaagt cctttagctc caaaaagcaa cggcataatg
     7381 tactgacccc aaaaagttag acaaataatt taagtaaagg atttagttct gtattgtaca
     7441 ggactgagtc cttttagttt taccttaatg cgtttgttgt tgtaataatt aatatagtct
     7501 gcaattgctt gttccaaatg ctcaattgac ttaaacgtct tctcataacc ataaaacatc
     7561 tcagacttaa gaatgccaaa gaaggattcc atcatgccgt tgtctggact attgccttta
     7621 cgtgacatgg atggttggat tcctttctcc tctaaaaaat gatgatagaa atcatgttga
     7681 tattgccatc cctggtcact atggagaatt gtatttttgt aatgtttctc tgtaaaggct
     7741 tgttctaaca tagctttcac ttgtatcaag ttcggtgact tagaaagatt gtaggcgata
     7801 atttcactat tgaagccatc taaaattggc gacaaataga gtttttggct gcttgctgga
     7861 atggcaaatt ctgttacatc tgtgtagcat ttttccaatg gtttggatgc ttcgaactgg
     7921 cgttggatga gattctctgc tttcatacca acctctcctt gatatgaaga atacttacgt
     7981 ttacggcgaa ttctagcggt taaaccaagt actttcataa gacgttgaac tctcttatga
     8041 ttaatcacaa ttcctcgatt tctcaattca agagtcattc gacgatagcc gtaatttcct
     8101 ttatgctcag taaaaatggc ttgaatttca gctttaatgt cataatcctt atcattttga
     8161 tccagctgtt ttaagtggta ataataggtt gaacgagcaa gcttaataat ctttagaagc
     8221 atatctaaag aaaactcagt taccaatcct cggacaattt ccgtttttct tcttgctctt
     8281 tttcttccct caatcggagt tctctcaact ttttaagaac tgcattctcc gctctaaggt
     8341 actcattttc tgcttgaaga cgttccattt cttccagttt tttctttggc ttacgtccca
     8401 ttttagataa ccttcctctt gttttctcaa caatagtata cccgtttttc ttatagtgtg
     8461 cgagccagtt aggaagcgtc ccacgatttg ggagagcata ttcaagagaa actctatctt
     8521 gagaatagcc tttatatagg actttatcaa tcatttcttg ttttaattca ggagagtagt
     8581 aacgattctt tcctttttta gcgatttcta ttccgtatcg atcaatcaat ttaatcatgt
     8641 agctaagatt agaaatgttt atcccaaatt tatttgaaag ctgatctaag ctatatcctt
     8701 ggtttctaag ttcatagatt tgaaccttat cttcataagt caatttcata ataaaaacac
     8761 cccgaaagtt agattttttc tgtctaactt ttggggtgca gttcataaaa ccgttgcttt
     8821 ttgcatgatt gtgatagact tggtgaaata gaattgacca aaaatcttct gaaatataac
     8881 aagagagtga ctcgaattta aaaagctaga gttccacaat tggaaatctc tagctttttt
     8941 gtgactgaga actttttgtc ccagcctcta ctttctactg actactatcc tgcatgccct
     9001 aagtcgagat agagaatatc tcgcttagtg gcatactcta gcgcatgttc aacagcctca
     9061 aataaatctg aagctagaaa ccttttcgta aagacggttt cgtctttacg cttaaatttc
     9121 gcaacataac tatgtttagt cattttttct ccttctaata ttcatattgt cctttaacac
     9181 cactatagat ccagtaaact gctttatcat aaacttgttt aaaggagata cctaatcgat
     9241 tggctacatc aagaattgaa atttgcttac attcctctat attcataaaa tatcatcatt
     9301 ttgtcgtagt attcggcaat gatggaacag atgaggattc ttctaaagtt ttaggagttg
     9361 ccttatctag atcatctaac ccagatttcc aaacctgtac ttggttgacc aataacttac
     9421 caggtagttt caaatagttc aaattaaccg ttctggtttc tgtttggttt gtctttgatt
     9481 agttggcatt ctttaaatca gatacataag ttacattata agagaccatg gcaatggctt
     9541 gattcgtagt ctgattgaca aagatatctg ctttttcaaa atgataatcc aaaatatagt
     9601 ccttatacac ttggttcatg gcatcatttt gacttgtcaa ttcttgagaa taggccgatt
     9661 cagtcatata aggttgaata cgtgtattat tttcccctag tttttctttc gtatagtact
     9721 gtgtcaaaaa ttcttttaca gtatctgatg ataaaatact tgctttatct tctgcttgtt
     9781 tgtcctctac aagtttagct gcagccaatt cgatttcttt tcgactttgt ttggcagtag
     9841 aatgttgacc aatagaatta gcagtaagtt gtggtgttga tgaggtggat atactaaaaa
     9901 atgaggagga aattgataat tacttcacct agctaaaagt tcaacgaatt agggagacat
     9961 taggtagcct catattactt tgattagttt ttgctataac attgtcaaat atgatgacaa
    10021 aaaaatccgt ccgcactttt ttacgagtag gacgaattaa atatgttata caaaccatca
    10081 gctttttaac aattctacat aaggtagttg ttgatgcaac tacctttttt ctatgctgat
    10141 tagaacaaat ttgacatggc tacaactgcg attatctgat atagagtatt atataaactg
    10201 attcctccta ccccttatcc acaattttaa tacggctact gccatcgtgc gacttgatga
    10261 taactagttg ctgagcaata ccttctttca tatcgtctac gtggctgatg acaccgacca
    10321 tgcggttttc accgatttgt tccagaacag aaatggcctt ggtcagggct tccttatcca
    10381 gtgagccaaa cccttcatcg atgaagagag cttcaacaac ggcacccttg ctggtatttt
    10441 ggacaacttc tgagagggat agggcaatgg ccagtgcagc gataaaggtt tcaccaccag
    10501 acaaggattt aacggagcgt tcactacctg tcagctggtc atagacgttg atatccaaac
    10561 cgaagtgatc acgcgccctg cgtccttcct cacttagaac aaaggaatag cggttatccg
    10621 ttaatagtcc gatgtagtta gcattggcat agtccaagat ttgttggaaa tactgacgga
    10681 taacgtagac ctcaagatta agacgaccag ttagagcagt attttctccc ttaaccacct
    10741 taaccaaatc actgagttct tggtgggcct taaaggcctc ttggttactg tcttgaaggg
    10801 ttttagccgc ttggtaggta gccgtcgcat ccttaagtcc cttttccatg acagaaaact
    10861 gagcgagctg cctatcatag atttcctgac aattctgtac tgcttgcgct agactatcga
    10921 gatctggttg ttcttgattt tggagaagct cttgcccctt acgaatctgc gcctgtaatt
    10981 cttgtttgag cgttgcatag gtcgttaatt tggcctgaag cataggaata gcttgattat
    11041 ttacctcaat aagccagagt tcgacctgct ctaagtcatt agcgagggct ccttcagcct
    11101 tgagactttg ctctaattca gcagataatc gcttaacatc ttgatttacc ttatctttag
    11161 acttagttat actctcaatc tgccccttta ttcctttaat gtcggcatga agttggttgt
    11221 aggcttcgct attttccttg acttgcttat tgtagaggtt cagctcctga tgagcaaggg
    11281 aaatccgttc ttgatatacc tcaacagact caagttctgg atgagcttcc tgcaggtcct
    11341 ctaggcgttc ttgagcttgg tcaagcactg ccttggcctc ttgataggtt ttagccaaat
    11401 ctgtcgcttt tttttgagcc ttacctagct catcttgata tcggatataa tctgtctctt
    11461 ccttatcata acgtttttgt aactcttgat aatactgctc aaccttcagg agtagggctt
    11521 gcccacggtc agtttcatag tctatcgaaa aatcaaaatc aaaccgtccc ttaacgtgct
    11581 cttctaattc ttgatagtgc ttttcaagag ttgccttgac tttagccact tggtcaagca
    11641 aatcctgacg tttagatgca acttcactca aggtagcctg acgatttgat aaagtagcga
    11701 cttgcttttc tttttgagct tgaagcttct ccacctgatc catgagattt ttcaaggcca
    11761 cttcatcagc ctgtgctcca ccaacattag ggtgttccag agcaccacaa accatacaag
    11821 gatgcccctc ctctaactct gcctgcagtt ggacaataat gagttgacgg cgtgaaacca
    11881 aagtccttct taactcctct tccaattctt tgagaatttc ttgagcttga tcaatatcaa
    11941 aagataacgt ttgatgacgt ttttcggtct ttgtcaactc ctgattcaag ttctctattt
    12001 ctttcaggtc ctgagcaagt tgattctcca cactgtagcc cacaatctgg aagagttttt
    12061 cggcctcatg taaactatct aaactaagac gattagcctc caagtcagac aaggacttgt
    12121 taagcatctc aacctctttt ctagcctgct gataggtctc ttccaactgc ttgtagttag
    12181 tcgttgaacg tttgattttc tcctgttctt gggcaagact ctgggcatag ataatattct
    12241 ctttccaagt ttcaagctcc tcttcttttt gaagaaaatc cttagattga actgtgagtt
    12301 cctctttttt agccttaaca tcctcaaacg cctgttgctt ttcacttaag gcttcttgag
    12361 caatttcaag gtcctgctct aattgcatca actgtttccg atactgcttc aaggtccgaa
    12421 tggtttcctg cagaccttga gcaaactgta attcctccag atgcactttt gcctctgcct
    12481 gtccttgagc cccctcctca atttccagac ggtaacgttc cttggcttgc tccaattctt
    12541 gaaaaatctt tgccaaatct tgggcagttt gcaagctctt ctgcagttgt gccaaatcct
    12601 cgtgggcagc cttcaagata cttttttgct tcgtaacatt ttcttgacgc tgagacaaaa
    12661 actcttcaag acgtgtcaat ttttcagagg ctggcgtttg ctccaagacg gataattctt
    12721 cctcagacca aacctgactg gcaaaatgac catctagctg agcctgacgc ttttccatat
    12781 ccttattact ctgacgaaga cgctcttcca agctcttttg aaaatggtca aaaatacccg
    12841 ttccaaagat tttctttaaa atttgagtct tggtcttaga atcttctttc aagaaacggc
    12901 tgaaatcatt ttgtggaagg agaataatct gtttgaactg ctcagcattg agccccaaaa
    12961 tctgctcaat ctggtcactc acttccttga tcttatcccc aagcttttca atttcctgac
    13021 caccaatctt atccacaatg actagagaag ccgtcgcctt ttgcatggta gtgcccccac
    13081 cctgcttggc cctctcttgc tggagaactc ggtcaatgcg ataaaggtga ttgccttgtt
    13141 ggaaatagaa agtcaccttg gtcaaatcat cctctggacc agcgaaagtt gaccgcatct
    13201 cctcaacatt acgatcacca ctggtcgtag caaacaaggc taccgtcatg gcatcaaaga
    13261 gagtactctt accagcccct gtatcccctc caatcaaaaa gaggggagca tggtcaaact
    13321 gagtgaaatt aataacttcc ttacgatatg gtccaaaatt ggtcaattct aactggactg
    13381 gtctcattgt cgactcctct caatctcctc aaaaacactt tccacaaggg cagtctgtct
    13441 ctcagataag acatcgcctc cagttactgt ctggtaaaaa tcaaatacga tttcctgggg
    13501 cgactgcatt tccaaatctt ttaagtgctg atcaacggtc aagttttctt ccctaacatc
    13561 acccagacga ctgaaagtaa tttctacaat gtctgtccca taaatctctt ccagtcgggc
    13621 acgcacattg ataccctcta attccttacg actagacagt tgaatatcaa aggcgaacca
    13681 ggctttttga caaggttgat tcttataaaa ttcaggtgac atcaaggttt taaaagattc
    13741 ctgtaaagcc acaatcggcc gtttaacctc tagagtatgg aaggtctgag acatatcacc
    13801 agacgcatcc aattcaagaa tatagacacc cttttcttcc ttacgcttgg cttctttgac
    13861 attaaaggcg actggactgc ctgaatattg cacgcgcttg gtaggactag caaaacgcgt
    13921 atggatatgc cctaaggcaa cataatcgaa agacttgaaa aggtcactgg tcacattggt
    13981 aagaccacct accgtattac tggtttcaga caacatcaat tctcgaagac cctgaccatc
    14041 gctatcatcc ttcttagaaa ccgcaaaatg cgtcaccaag acatgagctt tgtcaggatc
    14101 aaaagctttt tccatatcct caagaatgta ggtcaaggca tcaccaatcc cctgaatttc
    14161 ctttccctca tcatccttat agtaaatacg agcatcaata ggatcgataa aaggcagcag
    14221 aaaaatctgg caattctcca actcaatggg ctcaaaagcc tcctccaaac gtgtacttaa
    14281 atgaaggccc tgatgttgaa agaagtcacg cccaaaatgt aaacgttcag ccccatcgtg
    14341 attaccacta atcgcataga caggaatctg ctcctccagt accaagcggg ccaaggtctt
    14401 attaaaaagc ttaatcgcat ccacaggggg caccgcacgg tcatagaggt ccccagaaat
    14461 gataacccca tccacttttt cgctaatagc caaatccaca atttgttgaa aagcccactc
    14521 ctgctcctcc aacaaagacc agccattgag ggttcgtcct acatgccaat ctgacgtatg
    14581 taaaaacttc atgacaacct cctcattcat tttgtcttac ttctattgta ccttatcaag
    14641 ctaaatactg cttaaaagtt tcacaggctt tgatagtttt cccgtttttt agctgtaaag
    14701 atcaaaaaat ctctcccaag ctatcctgta ctgaccccaa aaagttagac aatttatgta
    14761 agcaaaggat ttagctctgt attgcacagg attgagtcct tttagtttta ccttaatgca
    14821 tttgttgttg tagtaatcaa tatagtctag attaccctgc ctcaattggt taagtaattt
    14881 aaatacctct aaccaagaaa atcaatatta tctattcttt taattgactt ttatagattc
    14941 taagcattat catataggtt ggtactagtg cacatcttgt attttaggca ataatattta
    15001 ctcacttttc gttattgtca gtaccgatcc tttttaaatt tttcactatg aaaacctaaa
    15061 aataatccga accctaaggg ctcctgactt tttactttat tctaggcttt ttttatccgt
    15121 agcttgttag ctgacttgga actaggcatg tagtatttac tatttcccta cttgagattt
    15181 tttataagtc acatgcatta ttccatctga acgaatggta tgatttttat ttcttttaga
    15241 gaaacaccgg taatagctaa ttcctatctt aaatcacttg aaatatattt ataatgtgtt
    15301 ggagtgctaa tcagtaccgc ttgtagattt ttggaagata ctaacacact aatgatttaa
    15361 tctcctttaa aacatgaaaa gagaagcctc caaagcttct cttttataat tatcaaataa
    15421 tgtacaacta gattcttaat aactacctaa tttagtggtt caatcatgaa gcttaattga
    15481 tagctatctg ctgagctaag caagaattcg tcatgaactg gagcacccca tgtgtcgtca
    15541 ccacctacac ccatttgagc agcaagaact ttaatccatg tagcatcaga ttcttgcaac
    15601 tcatattggt gacgagcatt ttcaatttgt tcagtactgt tacgcaaagc actgaattcg
    15661 aatgctttat taagtgcggt gaatttaaga ccattatggt tatcatcaga tactgtgaat
    15721 tcacgagtac catagtgatt accagattct tgtggcatta gatatggagc aaatgtcttt
    15781 tcaacagatg tttcatatcg accaagatag gcaccaggaa gtttatcacg gtagctttct
    15841 tctgcaccgt atccataata gctaaggttt gtaaattgtg aaccgatagc aaattctaga
    15901 ccaaattcag ggaagtttgg caaacctgct ttaccatcat agtttgcagt aacaaagatt
    15961 cgacccttgt aatcaacttg ataagttacc ttaacttcga catcagacaa gcctggcaat
    16021 tcatgaacat aagtcacttt aatagagtcg tcttcgattt gaatttgagt atctgtaact
    16081 ttactatagt ttccagcaac cttccagcct gccatttcga atggatatcc agcaccacga
    16141 tcgttgtcag tgtaagcacg agtgaagcta agtttaggac ctttctcaat gaattcaaca
    16201 ccattatact tagcagatac taaagtattt tgtgcacgtg aaagcaagat tgagaagttt
    16261 tgtccttgaa taccgatgtt gaagtcgcct tcaacaacat tcaaaggtgc tttaactggt
    16321 gtttcagtgc taatcttttc aacaacatat tgaccacgaa caatttcatg acctttagga
    16381 gcccattcag ttgcttccct cagaacacaa gcaacttcgt aaatttgttc agaatttgaa
    16441 gcctcgacta caaagttaac tgggaatgtt gcttcttcgc ctggtttaac atcaaagtga
    16501 tattcacttt cactaacttt tctaccatct tcgtaaactc tagctaggaa agtataagca
    16561 gaaagatctt cgaagagatt atcattcttg atagttactg atttttcatc aacagcaatc
    16621 ttaatattag agtaaagatg tttaactgtt tgaagttttg gagttagggt acgatctgca
    16681 aagacgatac catttccaca aaattcgtag tcagaaggtc tatcatgcca gtcaccacca
    16741 tatgatagga attcgctacc atttggaagt gttttgtaaa tagcttggtc aatgaagtcc
    16801 caaataaatc caccttggta ttctggatat ttctctaagt cagtgtagag ttgcaatcca
    16861 ccaccagagt tacccattgt gtgcatgtat tcacatgaaa tataaggttt ttgaggtttg
    16921 ttagttaggt tacctgaagc aaagtgttta tcactaacgc ttgaaagatc aactagttta
    16981 ccagttgtga ggtattcttc gatatcagct ggtttcgcat acatacgact ttcgatgtct
    17041 gtaatgtaat caaactcacg acaccatgca acaccttcat agtgaactgg acgagtattg
    17101 tcaacactac ggaagtaatc agccatgtca gcaatatctt taccagcata tgattcatta
    17161 ccacaagacc
//
