LOCUS       c00022_gnlPro..        15971 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EHJMNBFK_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 12:42:58
            Original ID  :: gnl|Prokka|EHJMNBFK_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15971
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15971
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2754:5971]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2755..5971
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..15971
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15971
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             complement(130..735)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="LysR_substrate (E-value: 6.1e-19,
                     bitscore: 58.7, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRIAYFNQLGRRQLDRIVDQFKQKHSDVEIELIGMGHDEAFD
                     KLAKNEVDLAISDLRDDQLDFKKEILGQEAVMAILQKGSYPSGVQMINKDDLADLTCFI
                     VAKPEEEAAELHLFKDIYQIRSPFIASNSVEEAALLVASGSGYFLMNETTASLISNDTL
                     QRLFLLSNGQQMWQKIAAFYTNEDAVIKDFILLAKKVY"
     CDS             complement(738..899)
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MSKQKKVRLLKFLSVVVSGINVVISLLIMLNKYQIRKDKKQIADE
                     SHAPLDEN"
     CDS             complement(915..2081)
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MKLKKNQDNLKQIASLIEYAFLKDSDLTTDSNFMTRYDHSDGYGY
                     FDQEKLTSYMMVNKFKAEIFGHHVPVAGIGYVASYPEYRGRGHISKLMKEILFDLHDQK
                     IPVANLAPFSEKFYRHYGFSNSIYQKEYRFSGAALASFRLPRKGKIIRGKWNDLIVQNG
                     VIQLYERQLHTDDERNTIIREAWWWNRLDDYYHHREIAVYFDEAGRPMSYLIYRIIDNC
                     FMADELYSITPQGLLSILGFMAVHIGSIKEFCMTLPGKSLLAELFPEQNELDIQLHPYM
                     MSRIIDFQKVLSCMRPLQGGTFNIEVNYDDQCPWNIGVWQLTNYDHQVKCERKEDELVD
                     FSGPITTWTQILLGRLTMESAIKFGLITDYRIKKLDFVKGKVSFYDYF"
     CDS             complement(2388..2738)
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MNIFQEGNPQNIAQVLAGKDYRVALQQAIFKKYPDATLVDINLNI
                     PGPIKNNRYLIKLFDYGIKQLEEIWQNKGYDYKLVKALNNDAGCENFYVLRESSKVVKL
                     STILFEENNKIG"
     CDS             complement(2755..3687)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="AA_kinase (E-value: 6.2e-38, bitscore:
                     121.2, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVVALGGNAIEAGDNSAAAQEKQVEKTMKVVAKMIENGDQVA
                     IVHGNGPQVGNLLLQQYKGSSKDNPAMPLDTVVAMTQGSIGYWMQKALDDQFKHTNYPH
                     QAVALITQIIVNANDPAFKNPTKPIGPFYTFNEMQKQKIYHPEYTYKQDAGRGYRQVVS
                     SPKPVKIINAPVIDTLLKSKFVPIAAGGGGIPVVVKDDSLQGVAGVIDKDFSAAKLAED
                     IQADELVILTTVDNAYVNYNQPDQAPIGKIKIDQLKKYLEAGQFAAGSMKPKIEAVIDF
                     VEKKGKTAIITSLRNASKLDDGVGTIVYN"
     CDS             complement(3690..4730)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="OTCace (E-value: 1.2e-50, bitscore: 162.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 1.9e-48, bitscore:
                     154.8, seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSLLKCKDYTPAELNYLIDFALHLKELKKENIPHE
                     YLKGKNIALLFEKSSTRTRSAFVVACNDLGANPEYMGAGEIHLGKKESIEDTAKVLGSM
                     FDGIEYRGFAQKDVEDLAKYSGVPVWNGLTDKWHPTQMLADFMTIKEKFGHLKGLTLAY
                     VGDGRDNVADSLLVAGSMLGVNVHIVTPKPLFTHPDVQKIAGGFAKDSGSRNLITDDIE
                     QGVKGANIIYTDVWVSMGENDWSERIKLLMPYTVTMKMMHMTGTPDDHLIFMHCLPAFH
                     DCTTKVGEEIYEKYGLSEMEVTDEVFNSQYAWQFTEAENRLHSIKAIMAATLGNLFIPS
                     VDEGSK"
     CDS             complement(4742..5971)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="Amidinotransf (E-value: 2e-104, bitscore:
                     339.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLIHVYSEIGKLKTVMLHRPGRELENLSPDILNRMLIDDIPYL
                     KIAQKEHDYFAHTLEKQGVHVVYLEDLLAQSLTNEDVRTKFVDQLLEESNIKKEDPLHQ
                     LLMDYLMAMPVNEMVKQIIAGIRKNEIQNATPSLADLAEDPDYPFYLDPMPNVYFTRDQ
                     QAAIGNGMTINRMTFRARKRESLFMETVLKHHPDLKNANIPIWRDRYTHGRLEGVDELI
                     LNNHVLAIGISQRTSAAAITDLAHSLFGHSSYDTILAIKIPHNHAMMHLDTVFTMINYD
                     QFTVHPFILDKSGKIDIYVLEQDDHGEIKITPETDLIKVLKNYLHLSEIDLIPTGGGDA
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGILVHEIHSSELSRGPGGPRC
                     MSCPLVREDL"
     CDS             complement(6044..6898)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     75.2; E-value: 9.5e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="LysR_substrate (E-value: 4.6e-30,
                     bitscore: 95.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 3.4e-24, bitscore: 75.2,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKQLRYFLVVAEEKQITSAAKRLYIAQPPLSYQLKQLERELEA
                     QLFKRTAHGMELTDAGQILQSYASEILSLSESVKNQVHKTISGELGTIAIGMASSSTGL
                     IPMKSFQDLTKFYPEINFDIYEDNTFGIIDKLEKKTIDLGIVRTPYNRNGLNAKTLTTE
                     RMMAVTVDPKFKDKTELRIKDLNEQPLIIYRRFEEIFNQTFAHHGIKPFYAVKCDDSRT
                     AITWAKRKMGIALVPESIASTYAPDDLLPIKHSNWITHLQLVWRKDQKVTPLMKRIIDS
                     LSR"
     CDS             7027..9300
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MSEKFHGLTQAEADKRLKKDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEGALILECILGKWIQSLFVLLMLLFAAFNGASKKKQSRRVLKTISHKLTPKVAVER
                     DGKWIKIDSKQLVRGDLISLQRGDVLAADVKMVSGKIACDESSITGESKPVKKNIDDTA
                     YAGTTVVEGDGLAIVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFDTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTA
                     DLTGIQDAANLNLLLLDKTGTITENKTAVASWSDLSDLSDKDVLALAGSATDKRNAGII
                     DIAIDEYLKENNIPVMDVEHFTPFTSDTGYSMAEVDGHNVKLGSFKQLSLIDKNANEAV
                     EGINFKAGRSVAVLIDDKLAGVFILQDKVRKDSKAALAELKKRGVRPIMLTGDNQRTAA
                     AVAEQVDLTGNVISIHDFDESTDIDELAGIADVLPEDKLKMVKFFQEKGYIVGMTGDGV
                     NDSPALKQAEVGIAVSNAADVAKRSSKMVLLDDGLSSIVKILDAGHRVYQRMTTWSLTK
                     LARTAELTMLLTFGYLFFNYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     RLAKIAFSLAAGWTVIGIAFISYLNMHGWSHNSISTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGIVQIADVALTFILALCGLAMAQISWQNLLITVVVALIAAIIIDLIYQPV
                     MKNR"
     CDS             complement(9368..9865)
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MRKQIISAAGIMLAVIGLGAATTQSVDAAVTNPVRQGKRLNLTRN
                     ATVYNRHGVKVGHLRKGKLYKVRAIKVINGNTYVKIRKNRFVKEEAFLPYMKSTVKVVN
                     RIKKHSFVYDENGEKIPGKFLKRGAEVNYLGHKEINKKPFIKIADGEYVKALNVLTTVT
                     NH"
     CDS             10078..10563
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="LRLLYGRSLEVAAALLQLGHGWLVLTVLPGIGFILYLFFGRQLSP
                     DEIFAIQEEQKKVQRHYLAEQRDMLKEYDLLPEKECLPRVRMLSELNLNNDDAILTFDN
                     QVKVFISGPELFDQMITDIKNAKKSVSLEFYTFYSDQLGHRVLKALEEAAVNGAKVE"
     CDS             10623..11627
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_12"
                     /sec_met_domain="PLDc_2 (E-value: 1.2e-27, bitscore: 87.0,
                     seeds: 83, tool: rule-based-clusters)"
                     /sec_met_domain="PLDc (E-value: 3.1e-09, bitscore: 27.4,
                     seeds: 30, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSGEAQPFISTSKKHWFTTPRLNYHLHRKLVIIDHHISYIGGFNI
                     GDQYVNKSPKFGHWRDTHLRVIGQSPILMEVRFAMDWNTSIRRTNLPKFELKELKPFTV
                     NRKDINDNKNVAMQIVYSGPDNQHYGIRRGYEGIIAGAKKYIYIQMPYLIPEESILEAL
                     IIAANSGIDVRIMVPCMPDHPFVYRATEYYAKYLVAHGVKVYKYNDGFIHAKTMVSGSN
                     ISSVGSANQDFRSYTLNFEVNSFNYNPALTQELKKIFEKDLDKCTLLTNDYFAQQSSWL
                     KFKQYFSRLLSPIFNEKPSIGLSDGGFTLYLKNAVLFLYLFFISYIAMITIKK"
     CDS             11640..11804
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="LANRVKIGVLNLMHDKLDTQQRFARVLPDADLTFFYPRMHYQNRP
                     VPPEVAKTS"
     CDS             12103..12417
                     /locus_tag="ctg22_14"
                     /transl_table=11
                     /translation="MDKTQIMQDPRLTINSVDDNGHLFMVSSLEKPEQNFIFSHIEYGR
                     KGLKKEYEREIAAHPERHYKKPENYSLSNPLFQWKDTQKTFFNNWLTQVKKSKLVLLDK
                     "
     CDS             12433..12609
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_15"
                     /sec_met_domain="PALP (E-value: 5.4e-14, bitscore: 42.7,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTIYNSVTELIGNTPLLKLNRVVPDDAADVYVKLEFENPAGSIK
                     DRIALAMIKKAER"
     CDS             12676..13155
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_16"
                     /sec_met_domain="PALP (E-value: 4.2e-29, bitscore: 92.3,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAAAKGYHIIIVMPETMSVERRKLMKGYGAELILTPGADGMKGS
                     IAKAEELVKEKGYFMPMQFENTENPNIHELTTGPEIIAAMNGISKSVDAFVAGIDTGGT
                     LSGIGHALRRENSSTKIFALEPTESPLLKDGKTGKHGIQGIAAGFIPKNLDKYLR"
     CDS             13184..13360
                     /locus_tag="ctg22_17"
                     /transl_table=11
                     /translation="MATAREVAKNEGFLPGISAGANIHGAIEIAKKLGKGHAVITVVPD
                     GDDRYLSTALFNA"
     CDS             complement(13504..14031)
                     /locus_tag="ctg22_18"
                     /transl_table=11
                     /translation="MAIDFSKYIASVKDFPNKGIVFRDITPILQDGELYRAATHELAEY
                     AKSRKADIIVGPEARGFIVGCPVATELGLGFVPARKPHKLPREVERASYDLEYGSNSLE
                     MHKDAIKPGQRVVLCDDLMATAGTLRASKKLIENLGGKLVGAAFYIELPDLKGREKLPD
                     VDIYSLVQYHGA"
ORIGIN
        1 ttagctatta caacgctcaa aataatcgtg ctcggagtct aacaggtttt caggaacggc
       61 ttgaagttgc agttttagct tacaatatgg catattgtct agaacgattt aactagcacc
      121 acgcgtagat taatatactt ttttagctaa caaaataaaa tctttaatta ctgcatcttc
      181 attggtataa aaagctgcaa tcttttgcca catttgttgt ccattagaca ataaaaacaa
      241 tcgttgtaaa gtatcattac taattaaact ggcggttgtt tcattcatta aaaaatatcc
      301 tgatccagaa gctactaaca atgctgcctc ttctacggaa tttgaagcaa tgaatgggct
      361 tctaatctga taaatatctt taaataaatg gagttctgca gcctcttctt caggcttagc
      421 tacaataaaa caggttaaat cagctagatc atctttattg atcatctgaa caccgctagg
      481 ataactaccc ttttgcaaaa tagccattac tgcttcctga cctaagattt ctttcttaaa
      541 atcgagctga tcatcacgca aatcactaat tgctaaatca acttcatttt tggctaattt
      601 atcaaaagct tcatcgtgtc ccattccaat taattcaatt tctacatcag aatgtttttg
      661 cttaaattgg tctacaattc gatctaattg tcttctacca agttggttaa agtatgctat
      721 tctcaatttt ttcatagtta attttcatcc aatggggcat gactttcatc tgctatttgt
      781 tttttatctt ttctaatttg atatttgttg agcataatca atagcgaaat aaccacattt
      841 attccactaa ctaccacgct taaaaatttt agtaatctaa ctttcttttg cttactcatt
      901 ttggatacct tcttctaaaa ataatcataa aatgagactt taccttttac aaagtccaac
      961 tttttaattc gataatctgt gatcaaacca aatttaattg cggattccat agttaaacgt
     1021 cctaataaga tttgagtcca tgttgtaatt ggaccagaga aatcaactag ttcatcttct
     1081 tttcgttcac acttaacttg gtgatcataa ttagttaatt gccaaacgcc aatattccat
     1141 ggacactgat catcataatt aacctcgatg ttaaaagtac ccccttgcaa tgggcgcatg
     1201 catgacaaga ctttttggaa atcaataatt ctactcatca tatatggatg aagttgaata
     1261 tccaattcat tttgctctgg aaaaagttca gccaataaag acttcccagg caatgtcata
     1321 caaaactctt taattgaccc tatatgaact gccataaagc ctaatatgct taataatcct
     1381 tgaggcgtaa ttgaatataa ttcatcagcc ataaaacagt tatcaattat gcgataaatc
     1441 aagtagctca tcggccgacc agcttcatcg aagtaaacag caatctctcg atgatgataa
     1501 taatcatcta atctattcca ccaccaagct tctctgataa tcgtatttct ttcatcgtca
     1561 gtatgcaact gacgttcata taattgaatc acaccatttt gaacaatcaa atcattccat
     1621 tttccacgaa ttatcttacc tttgcgtggt aatctgaaag aagcaagtgc agcccccgaa
     1681 aagcgatatt ctttttggta aatactattg ctaaaaccat aatgacgata aaatttttct
     1741 gaaaatggag ctagatttgc aactgggatt ttttgatcat gcaaatcaaa aagaatttct
     1801 ttcattaatt tagatatatg tccacgtcct ctatattcag gatatgatgc cacataacca
     1861 atacctgcca ctggaacatg atgaccaaat atctcagctt taaacttatt gaccatcata
     1921 taactggtca atttttcttg atcaaaatat ccatatccat cactatgatc atatcgggtc
     1981 ataaagttac tatctgtagt caaatcagaa tcttttaaaa aagcatattc aatcaatgaa
     2041 gcaatttgtt ttaaattgtc ttggtttttc tttaatttca tagttttcct tacaatatat
     2101 attcataact tcacttatat tttagaacat tttatgtatt tttcgttagc tttttttaag
     2161 atttaaatga aaaaacagga tgattagcct cccatcccgt tttaattatt tacatacttc
     2221 gcatataaac tagaaatgta tctttgcatc tcttctactg agtgtcgccg tgatcgagca
     2281 cactctttag cagggcgatt gcataaatag cagcggcgac tagagtattc aagctcttgg
     2341 cgtgaaagtg cagttcttcc tttaattaat acatcggcat caaataatca tcctatttta
     2401 ttattttctt caaataaaat tgtagataat ttaactactt tgctagattc tcgcaaaaca
     2461 tagaaatttt cacatccagc atcattattt aatgctttta ctaatttata gtcatatccc
     2521 ttattctgcc atatttcttc taattgttta attccgtaat caaataattt gattaaatat
     2581 cgattatttt taattggccc tgggatattt aagtttatat caaccaaagt cgcatcagga
     2641 tactttttaa aaatagcttg ctgcaaagct acacgataat cttttccagc taatacctga
     2701 gcaatatttt gcggatttcc ttcttgaaaa atgttcattt atatctcacc gcagttaatt
     2761 ataaacgatt gtacctactc catcatcaag tttacttgca tttcttaaag aagtaataat
     2821 tgcagtcttt ccttttttct ctacgaaatc aatgacagct tcaatttttg gcttcatgct
     2881 gcctgcggca aattggccag cttctagata cttctttaat tgatcaatct ttatttttcc
     2941 aataggagct tgatcaggtt gattatagtt cacgtaggca ttgtcaacag tagttagaat
     3001 aactagttca tctgcttgaa tatcttcagc tagttttgcg gcactgaagt ctttatcaat
     3061 tactcctgct acgccttgca aactatcgtc tttcactaca acaggaattc caccacctcc
     3121 ggcagcaata ggaacaaact tgctctttag taaagtgtca atgactggtg cattaataat
     3181 tttaacgggc tttggagaag aaactacttg acgatagcct cgacctgcat cttgcttata
     3241 agtatattca ggatgataga ttttttgctt ctgcatttcg ttaaatgtat aaaatgggcc
     3301 aattggttta gttggattct taaaagctgg atcattcgca ttaactatta tctgagtaat
     3361 caaagcaaca gcttgatgtg gataatttgt atgtttaaat tgatcgtcta aggccttttg
     3421 catccaatag ccgatactgc cttgagtcat tgctactact gtatcaagcg gcatagcggg
     3481 attatcttta cttgaacctt tgtattgttg caaaagcaaa ttaccaacct gcgggccatt
     3541 accatgaaca atcgctacct gatcaccatt ttcaatcatt ttagcaacaa ccttcattgt
     3601 cttttcaacc tgcttttctt gggcagctgc actattatca cccgcttcaa tagcattgcc
     3661 acccaaagct acaactattc ttttcatctt tatttacttc cttcatcaac tgacggaata
     3721 aacaaattgc ccaaagtagc ggccattatt gctttgatag aatgcaatct attttccgct
     3781 tcagtaaatt gccaagcgta ttgagagtta aagacttcat ctgtcacttc catttcactt
     3841 agaccatatt tttcataaat ttcttcgcca actttagtag tgcaatcatg aaacgcaggc
     3901 aaacagtgca taaagattag atgatcatct ggggtgcctg tcatatgcat catcttcatt
     3961 gtaaccgtgt aaggcattaa caatttgatt ctctcactcc agtcattttc acccattgat
     4021 acccagacat cagtataaat aatatttgca cctttaacgc cttgttcaat gtcatcagta
     4081 atcaaatttc ttgatccaga atctttggca aaacctcctg caattttttg tacatcaggg
     4141 tgagtgaata aaggcttggg cgtaactatg tgtacattaa ctccaagcat gctgccagcc
     4201 actaaaagac tgtcggcaac attatcacgt ccatcgccta cataagctaa agtaagtccc
     4261 tttaaatgtc caaacttttc tttaatagtc ataaagtcag ccaacatttg ggtcggatgc
     4321 catttatctg ttaaaccatt ccaaacaggg acaccagaat atttagccaa atcttctaca
     4381 tctttttgag caaaaccgcg atattcaatg ccgtcaaaca tactgcccaa aacctttgca
     4441 gtatcttcaa tactttcctt tttacctaaa tgaatttcac cagcacccat atattcagga
     4501 tttgcgccta aatcattgca tgcaactaca aaggctgaac gtgttcttgt tgaagatttt
     4561 tcaaataaaa gagctatatt ctttcctttt aaatattcat gcggaatatt ttctttcttt
     4621 agttccttca aatgaagtgc gaaatcaatt agatagttaa gctccgctgg agtatagtct
     4681 ttgcatttta ataaacttct gccttgaaat acattttgta aatatttcat tttgacgcct
     4741 cttacaaatc ttcacgaaca agtggacatg acatacatct tggacctcca gggccacgag
     4801 aaagctcact tgaatgaatt tcatgaacta aaatgccatg ctttcttaac aaatcatttg
     4861 atacataatt acgatcatat gtaacgactt cacctggcgc aatagccaaa gtattcgagc
     4921 catcattcca ctgctctctt ggggctgcaa ttgcatcccc acctccggtt ggaattaggt
     4981 caatctccga taagtgcaaa taattcttta acactttgat caaatcagtt tctggggtaa
     5041 ttttaatctc accatgatca tcttgctcta aaacataaat atcaatcttt cctgatttgt
     5101 ctaaaataaa aggatgaacg gtaaactgat cataattaat cattgtaaag actgtatcca
     5161 gatgcatcat ggcatgatta tgtggtattt taattgctaa aattgtgtca taactagaat
     5221 gaccaaacag gctatgagca aggtcagtga ttgcggcagc ggaagttctt tgagaaatac
     5281 cgattgctaa aacatgattg tttaaaatca gctcatcgac accttctaaa cgtccatggg
     5341 tgtaacgatc acgccaaata ggaatattgg cattttttaa gtcgggatga tgctttaaaa
     5401 cggtttccat aaataatgac tcacgttttc tagctctaaa tgtcattcta ttaatagtca
     5461 tgccattacc aatagctgct tgttgatcac gagtaaaata cacatttggc attggatcca
     5521 aataaaatgg ataatctgga tcttcagcta gatcggctaa tgaaggagtt gcattttgta
     5581 tttcattttt tctaatacca gcaattattt gcttaaccat ttcatttact ggcattgcca
     5641 ttaaatagtc catcagtaat tgatgtaatg gatcttcttt ttttatattg gattcttcta
     5701 ataattgatc cacaaatttt gtacggacat cttcattagt caaagactga gctagtaaat
     5761 cttctaaata aacaacatga actccctgtt tttccaaagt gtgggcaaaa taatcatgct
     5821 ctttttgagc tatttttaaa tatggaatat cgtcaattaa cattcgattt aagatatctg
     5881 gtgaaagatt ttctaattct cttcccggtc gatgcagcat aactgttttt aatttgccaa
     5941 tttcggaata aacatgaatt aagtcagtca ttatatagtc tcctaattca aattatgtat
     6001 ttgtttacaa taattatgga tcaattaggt agaagttaca atcttaacgg cttagtgaat
     6061 ctattattct tttcattaaa ggcgtcacct tttgatcctt gcgccacact aattgcaaat
     6121 gcgtaatcca attactatgt ttaataggaa gaagatcatc aggtgcatac gtagaagcaa
     6181 tagattcagg aacaagagca atccccattt ttctcttcgc ccaagtaatc gctgttctag
     6241 aatcatcaca tttaacagca taaaacggct taatcccatg atgagcaaaa gtctggttaa
     6301 aaatttcttc aaatcttcga taaataatga ggggctgctc atttagatct ttaatcctta
     6361 attccgtctt atccttaaat ttgggatcaa cagtaactgc catcattctt tcagtagtta
     6421 aagtttttgc atttaagcca ttacgattat aaggcgtacg cacaattcct aaatcgattg
     6481 tcttcttttc caatttatcg ataatgccaa aggtattatc ttcataaata tcaaagttga
     6541 tttccggata aaacttagtt aaatcttgaa aacttttcat aggaattagt ccagttgatg
     6601 atgaagccat gcctattgca atcgtgccta gttcacctga aatagtttta tgaacctgat
     6661 ttttcacgct ttctgataaa gagagaattt cactagcata gctctgcaaa atttgtccag
     6721 catctgttaa ttccattcca tgagcagtac gcttaaataa ttgtgcttct agttctcttt
     6781 ctagttgctt taattgataa ctcagcggcg gttgtgcaat gtatagtctt ttagctgctg
     6841 aagtgatttg cttttcttcg gctactacta aaaagtagcg taattgttta atattcatta
     6901 ataatctatc ctttttattt tagttgtatc tcttattaaa aatttctata tcttatattt
     6961 taatttagta ttttcattca aacaacatat gtgctacttt attaaggtag atttggaggg
     7021 aataaaatgt ctgaaaaatt tcatggctta actcaagccg aagcagataa gagacttaaa
     7081 aaagatgggt taaacgaagt acctgaaccc gaatacaact tttttaagga atttctatca
     7141 aaattatgga atctttctgc ctggattcta gaaggtgcct taatcctcga atgtatctta
     7201 ggcaaatgga ttcaatcttt gttcgtcttg ttgatgcttc tttttgcggc ttttaacggt
     7261 gcatccaaga agaaacagtc acggcgggta ttaaaaacca tttcacataa gctaacccct
     7321 aaggtggctg tagaacgcga tggtaagtgg atcaaaattg actctaagca attagttaga
     7381 ggtgacttaa tctcacttca acgtggggat gtacttgcag ccgatgtaaa aatggttagc
     7441 ggtaagatcg cctgtgatga aagctcaatt accggtgaat ccaagcccgt taaaaagaac
     7501 attgatgaca cagcttatgc tggtactact gttgttgaag gcgatggatt agcaattgtt
     7561 actgcaactg gtaaagattc aagaagtggt aagaccatta acttgatcaa caattcagct
     7621 gcacctggtc acttgcaaca gcttttaact aagattattt actacctttg cctacttgac
     7681 ggtgtactta ccttagttat tatcattgct tcattcttta agggtggtaa ttttgatacg
     7741 tttatcaaca tgttgccatt cttagccatg atgttcatcg cttcaattcc ggttgcgatg
     7801 ccgtcaacct ttgcattgtc caattcattt gaagcaaccc gtttaagtaa agaaggcgtc
     7861 ttaacagctg atttaactgg tatccaagat gcagctaact taaacttgct tttacttgat
     7921 aagacgggaa caatcactga aaacaaaact gcagttgcta gttggagcga tttaagcgat
     7981 ttgtcagata aagatgtact tgctttagcc ggtagtgcaa ctgataagcg taatgcaggt
     8041 atcattgata tcgccattga tgaatactta aaagaaaaca atatccctgt catggacgtt
     8101 gaacacttta ccccatttac ttctgacact ggctattcta tggctgaagt agatggtcac
     8161 aatgttaagt taggttcatt taagcaactt tcattaatcg ataagaatgc aaatgaagca
     8221 gttgaaggca tcaattttaa agctggacgc tcagttgccg tgttaattga tgacaaactt
     8281 gcgggagtat ttatcttaca agataaagta agaaaggact ctaaggctgc tttagcagaa
     8341 cttaaaaaac ggggcgtacg tccaatcatg ttaactggtg ataatcaaag aactgccgca
     8401 gcagtcgctg aacaagttga tttaactggt aacgttatct ctattcatga ctttgatgaa
     8461 agcaccgata ttgatgaatt agcagggatt gccgatgttt tacctgaaga taaacttaag
     8521 atggttaaat tcttccaaga aaaaggttat atcgttggta tgactggtga tggtgttaac
     8581 gactctcctg ctttaaagca agctgaagtt ggtattgctg tttctaacgc tgccgatgtt
     8641 gccaagcgtt caagtaagat ggtgcttcta gatgatggct taagctctat tgttaaaatt
     8701 cttgatgctg gtcaccgtgt atatcaacgg atgactactt ggtcacttac taagctcgcc
     8761 agaaccgccg aattaactat gcttttaacc ttcggctatc tcttcttcaa ctatattcca
     8821 atggcattaa atgctatggt tatttacaca atcatgaata acatggttac catgatgatt
     8881 ggtactgacc gtacccatat tacttacaaa ccagaaaatt ggaatatggc aaggttagcc
     8941 aaaatcgcat tctctcttgc tgcaggttgg acagttatcg gtatcgcttt tatcagctac
     9001 ctcaacatgc atggctggag tcacaattct atctctacca tggtctatgt ttacttagtt
     9061 ctaagtgcaa tgttaattgt attaattact agaactcgta aatacttctg gcaagattac
     9121 ccatctaaac ttgtaggtat tgttcaaatt gccgatgtcg cattaacctt tattttagct
     9181 ttatgcggtt tagcaatggc tcaaattagt tggcaaaact tattaattac cgttgtggtt
     9241 gcattaattg cagcaattat tattgatttg atttatcaac cagtaatgaa aaacagataa
     9301 ttaacttaaa acaaaaacac tctgaaaact acattactac aatgtagttt tcagagtgtt
     9361 tttttgatta atgattagta actgtagtca agacattcaa agccttaaca tattcaccat
     9421 cagcaatttt gataaatggt tttttattaa tttctttatg gcctaaatag ttaacctcag
     9481 caccacgctt taaaaatttg cctgggattt tttcaccatt ctcatcataa acaaaggaat
     9541 gctttttgat tctattaact acttttacag tagacttcat atatggcaag aaggcttctt
     9601 ccttaacaaa tctattttta cgaatcttta cataagtatt accattaatt acttttatgg
     9661 cacgtacttt gtaaagcttt ccctttctta aatgtccaac tttaacacca tgtctattat
     9721 aaacagtagc atttctagtt agatttaatc tcttaccttg tctaactgga ttagtaacag
     9781 ctgcatcaac gctttgtgta gttgctgcgc ctaatccaat aactgctaac attatacctg
     9841 cagcagaaat aatttgtttt ctcatcataa tccacccccg tagtgtttat accattcttc
     9901 atcccttatt ttatcaaaaa ttatcgaatt ggaagcattt tttactcatc tgttttataa
     9961 ctatttgctt aattctgcta aaattattta taacactact tacaagggag taattattca
    10021 tgattttaac ttgggatata atccgtagga ctatcgaagt cttatggatt atcaatattg
    10081 cgtttgctgt atggacggtc tttagaagtc gccgcagcgt tgttgcaact tgggcatgga
    10141 tggcttgtat taaccgttct gcccggtatt ggttttatcc tatatctttt ctttggtcgt
    10201 cagctttcac ctgatgaaat ctttgctatt caagaagagc aaaaaaaggt acaaagacat
    10261 tatttagctg agcaacgcga catgcttaaa gagtacgatc ttctacctga aaaagagtgt
    10321 cttccacgag taagaatgct ttcggaacta aatcttaaca acgatgatgc gattttaact
    10381 tttgataatc aggtcaaagt ttttatttct ggaccagaac tttttgacca aatgattact
    10441 gatatcaaaa atgccaaaaa atccgtcagc ttagaatttt atacttttta ttctgaccaa
    10501 ttagggcatc gtgttttaaa agccttggaa gaggctgcag ttaatggtgc taaggtagag
    10561 taatttatga tacctctgga tcaagaggca ctaagccaag cttttgtgac catttaagag
    10621 aattgagcgg cgaagctcaa ccatttattt ccacttcaaa aaagcactgg tttactaccc
    10681 cacgactcaa ttaccactta catagaaaat tagttattat tgaccaccat attagctata
    10741 ttggcggatt taatattgga gatcaatatg tcaataaatc accaaaattc ggtcattggc
    10801 gggataccca tttacgtgta attgggcaat cgccaattct aatggaggtc cggtttgcaa
    10861 tggactggaa cacgtcaatc agaagaacaa atttacctaa atttgaatta aaggaactta
    10921 aaccatttac tgtcaatcga aaagatatca atgataataa aaatgtcgct atgcaaattg
    10981 tttactcagg acctgataat caacattacg gcatcagacg aggctatgaa ggaattattg
    11041 caggagctaa aaaatacatt tatattcaaa tgccttattt aattcctgaa gaatcaattc
    11101 ttgaagcctt aattatcgct gctaacagcg gtattgatgt tcgaattatg gttccttgca
    11161 tgcccgatca tccatttgtt tatcgtgcta cagaatatta tgctaagtat ttagtagccc
    11221 atggcgttaa agtatacaaa tataatgatg gttttattca tgcaaaaact atggttagcg
    11281 gttctaatat ttcttcagtt ggttccgcca atcaagattt tcgaagctat acattaaact
    11341 ttgaggtaaa ctcattcaac tacaaccctg ctttaactca agaattaaag aaaatttttg
    11401 agaaggactt agataaatgt acccttttaa ctaatgacta ctttgctcaa caatcatcat
    11461 ggttaaaatt taagcaatac ttctcaagat tattatcacc tatttttaat gaaaagccct
    11521 ctatcggtct atccgatggg ggttttactt tgtatttaaa aaatgcagtt ttatttcttt
    11581 acttattttt tataagttat atagcaatga taactattaa aaagtaagga ggataaaact
    11641 tggctaatag agtaaaaata ggcgttttga atttaatgca cgataagtta gatactcaac
    11701 aaagatttgc acgcgttttg ccagatgcag acctgacttt cttttatcca cgtatgcatt
    11761 atcaaaatcg tcctgtccca cctgaagttg caaaaacttc ctagccatta gatcttaatc
    11821 gaatcaaaga gtttgatggc tttatcatta cgggcgcacc tttagatcat cttgattttg
    11881 atcaagttac ctacatcgag gaagtccgat gtttgctcca actattagat aaatacaagt
    11941 tgcagcaatt atatttttgc tggggtgcaa tggccgcttt agattatttt tacaatattc
    12001 aaaaaaatct ttggtgtttt tcctcattta attatcgaac cacatccttt attaaatggt
    12061 ctcagccaag gatttatcgc tccacatgct cgttacgctg aaatggataa aacacagatt
    12121 atgcaagatc cacgattaac cattaattca gttgacgata atgggcatct atttatggtc
    12181 tcttctttag aaaagcctga gcaaaatttt attttctctc atatcgaata cggccgaaaa
    12241 ggccttaaaa aagaatatga aagagagatt gctgcacatc cagagcgaca ttataagaag
    12301 ccagaaaatt attcattatc aaatccattg tttcaatgga aagatactca gaaaacattt
    12361 ttcaataact ggctaaccca agttaaaaaa agcaaattag tattattaga taaataaaac
    12421 gaggtataca ttatgtctac aatttataat tcagttacag aacttatcgg caacactcca
    12481 ttacttaagt tgaatcgcgt tgtacctgac gacgcggcag atgtctatgt aaagttggaa
    12541 tttgaaaatc cagctggttc aattaaagac agaattgctt tagctatgat caaaaaagct
    12601 gaacgttaag gcaacttaaa gccaggtggc acaattgtag aacctacttc aggcaatacc
    12661 ggtatcggtt tagccatggt tgctgcagct aagggctatc acattattat tgttatgcca
    12721 gaaactatga gtgttgagcg tcgtaaatta atgaagggct atggtgctga actcattttg
    12781 acaccaggtg cagacggtat gaaaggttca attgctaagg ccgaagaatt agttaaagaa
    12841 aaaggctact tcatgccaat gcaatttgaa aatacagaaa atcctaatat tcatgaatta
    12901 actactggtc cagaaattat tgccgcaatg aatggtatca gcaaatccgt tgatgccttt
    12961 gttgctggta ttgatactgg tggtacttta tcaggaattg gacatgcact taggcgtgaa
    13021 aattcatcca ctaagatatt tgcacttgag ccaactgaat ctccactctt aaaagatgga
    13081 aaaacaggta aacatggtat ccaaggtatt gccgcaggtt tcatccctaa gaatttagat
    13141 aaatatctac gatgatataa ttacagtttc tactgatgaa gcaatggcta cagctcgtga
    13201 agtagctaaa aacgaaggct tcttacctgg tatttcagct ggtgcaaaca tccatggtgc
    13261 aatcgaaatt gctaaaaagt taggcaaggg acatgctgtg attactgtag ttccagacgg
    13321 cgatgatcgt tacctttcaa ctgcattatt taatgcttaa aacttaattt ctgtaaacaa
    13381 atactcctaa ggaaaatttc cttaggagta ttatttttat ttctgttgat tgtgcaccag
    13441 tcaatgctgg tacaacactt ttagtataat gacctttact aattagatca atattgaatt
    13501 tatttaagca ccatgatatt gcactaagct gtaaatatca acatcaggca acttttctct
    13561 accctttaaa tcaggcaatt caatgtaaaa tgcagcacct acaagcttac caccaagatt
    13621 ttcgattaat ttcttagaag ctcttaaagt acctgcagta gccattaaat cgtcacagag
    13681 aacaactctt tggccaggct taattgcatc tttatgcatc tcaaggctat ttgaaccgta
    13741 ttccaagtca tatgaagcac gttcaacttc tcttggcaac ttatgtggct ttcttgctgg
    13801 aacaaaacct aagcctaact cagttgcaac aggacagcct acaataaagc cacgtgcttc
    13861 aggacctaca attatatctg cctttctact ctttgcatat tctgccaatt catgagtagc
    13921 agcacgatac aattcaccat cttgcaaaat aggtgtaata tcgcgaaaga caattccctt
    13981 attaggaaag tccttaacac ttgcaatata tttactaaaa tcaatcgcca taagaagaaa
    14041 aacctccata attctgtgcg tttgtattca aacacttttg acttgtatat tttaccaaag
    14101 atttgttata aaagcactga aatcttgata tttatctacc tttttaccaa attattaata
    14161 tatgtaatta atttttgagt aggtatcgtt cttagttgat taataaattt aatttgtgaa
    14221 ctcgttacca ttaaatattt agaagctgtc aatggttgct tctttggatt agactcacca
    14281 actaattttt gatcatctaa tttaacaaaa cctaattcaa agaatactcg caaaataaac
    14341 aatacactat cataatccaa acctagatat ggtgctacag tgcaatagtc ttcaggcttt
    14401 aatgctggat gggcataaat atactttaac acttttccga aataactctt tgctggaata
    14461 tgttcaacag gtaactgatc taataaaaag cgtaaataaa tttgttgata atctttttct
    14521 aaagctgcat ttaattccac ttgattgcga ggcacatcaa gcaaagctac tgtttcaccc
    14581 gattgatcat aatctttaac caagctaatt ttatcatcat caatttgaag gcaattctta
    14641 acaattggaa tattcttttt gtcaaaaagc aaataacgat ctgcaaagcc catgacaaat
    14701 ttctcttgtc ttaaatcaat tactgatgtt ggcatagcta atttggggga tgcaaaagct
    14761 attccttcca tgatgccttg caaagatact tgtttgcgat aagtattcaa agagagagta
    14821 acaaagattt ttgaaataaa tggtaacaaa ttattattca aataatcctt attaaatccc
    14881 acaattgcta aattgccgtc ttttttatta gctgttaatt taacatgatt cttatctttt
    14941 cctattttga aaaagtgtgt aatagttgga tccgaaatac taaaaattgg ctgcggatca
    15001 ccagtaccaa atggtcccac ttgattaatt tgagccaaag tttgaggtga taagtcatgc
    15061 ataggcaatt ccatatcgta ctctttagtc tctaaaccac tgtcaacatg aaaatcggct
    15121 tcaaactttt cccgtaggtc atttacttta tcttcttcca tggataaacc acaagcaaaa
    15181 tcatgacctc caaatttggt caatagactt tcttttaacg gattaagagc atcaaataag
    15241 ttaaaaccac tgaatgaacg acctgatccc ttaatctccc cttcatcgtt tttagttaaa
    15301 acaattgttg gtttatgcag tttttccact atcttgttag caacaagccc caaaactcct
    15361 tcatgaaaat caggatcata taaaactaaa gtattttgct tttgccaact attttcatga
    15421 actaattcca tgcagcgatc gtaaacctca gtagttagct ctttacgctt attatttaag
    15481 tcttcaatct gatctgcgat cttctgtgcc tcaagatcat catcactaag caaaagctct
    15541 actgccagat tagcattagc caaacgtccc acagcattaa gtctaggagc aatattaaag
    15601 cctatatctg tctcattaat cgtttctagc gttaaaccgg catttttgat aagcgctctt
    15661 aagcccggtc gttcggtttg attaagaaca tctaacccac gttttacaat aatatggcct
    15721 tcaccagtaa ctttaaccat gtcaccaata gtaccgatca ttgctaaatc tagcaattct
    15781 ggtacaggat cctgcataag ctcacgacaa atcgtataag ctacacctgc accacaataa
    15841 tcatcaaaag gatattcttg acccggataa ttacagtgaa caattgcata agcatctggc
    15901 ttattttctt gaaaagtatg gtgatccgta ataatagtat ccacgccatg tcctttagcg
    15961 tattcaactt c
//
