LOCUS       c00019_gnlPro..        15970 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GHAGBILO_19.
ACCESSION   c00019_gnlPro..
VERSION     c00019_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 12:38:05
            Original ID  :: gnl|Prokka|GHAGBILO_19
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3700
            Orig. end    :: 19670
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15970
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[13700:16917]"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13217
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /neighbourhood="10000"
                     /product="Arginine2_Hcarbonate"
                     /protocluster_number="1"
     cand_cluster    1..15970
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Amidinotransf and OTCace and OTCace_N
                     and AA_kinase)"
                     /kind="single"
                     /product="Arginine2_Hcarbonate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15970
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Arginine2_Hcarbonate"
                     /region_number="1"
                     /rules="(Amidinotransf and OTCace and OTCace_N and
                     AA_kinase)"
                     /tool="gutsmash"
     CDS             1941..2468
                     /locus_tag="ctg19_6"
                     /transl_table=11
                     /translation="MAIDFSKYIASVKDFPNKGIVFRDITPILQDGELYRAATHELAEY
                     AKSRKADIIVGPEARGFIVGCPVATELGLGFVPARKPHKLPREVERASYDLEYGSNSLE
                     MHKDAIKPGQRVVLCDDLMATAGTLRASKKLIENLGGKLVGAAFYIELPDLKGREKLPD
                     VDIYSLVQYHGA"
     CDS             complement(2612..2788)
                     /locus_tag="ctg19_7"
                     /transl_table=11
                     /translation="MATAREVAKNEGFLPGISAGANIHGAIEIAKKLGKGHAVITVVPD
                     GDDRYLSTALFNA"
     CDS             complement(2817..3296)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_8"
                     /sec_met_domain="PALP (E-value: 4.4e-29, bitscore: 92.3,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAAAKGYHIIIVMPETMSVERRKLMKGYGAELILTPGADGMKGS
                     IAKAEELVKEKGYFMPMQFENTENPNIHELTTGPEIIAAMNGISKSVDAFVAGIDTGGT
                     LSGIGHALRRENSSTKIFALEPTESPLLKDGKTGKHGIQGIAAGFIPKNLDKYLR"
     CDS             complement(3363..3539)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_9"
                     /sec_met_domain="PALP (E-value: 5.7e-14, bitscore: 42.7,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTIYNSVTELIGNTPLLKLNRVVPDDAADVYVKLEFENPAGSIK
                     DRIALAMIKKAER"
     CDS             complement(3555..3869)
                     /locus_tag="ctg19_10"
                     /transl_table=11
                     /translation="MDKTQIMQDPRLTINSVDDNGHLFMVSSLEKPEQNFIFSHIEYGR
                     KGLKKEYEREIAAHPERHYKKPENYSLSNPLFQWKDTQKTFFNNWLTQVKKSKLVLLDK
                     "
     CDS             complement(4168..4332)
                     /locus_tag="ctg19_11"
                     /transl_table=11
                     /translation="LANRVKIGVLNLMHDKLDTQQRFARVLPDADLTFFYPRMHYQNRP
                     VPPEVAKTS"
     CDS             complement(4345..5349)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PLDc"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_12"
                     /sec_met_domain="PLDc_2 (E-value: 1.3e-27, bitscore: 87.0,
                     seeds: 83, tool: rule-based-clusters)"
                     /sec_met_domain="PLDc (E-value: 3.2e-09, bitscore: 27.4,
                     seeds: 30, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LSGEAQPFISTSKKHWFTTPRLNYHLHRKLVIIDHHISYIGGFNI
                     GDQYVNKSPKFGHWRDTHLRVIGQSPILMEVRFAMDWNTSIRRTNLPKFELKELKPFTV
                     NRKDINDNKNVAMQIVYSGPDNQHYGIRRGYEGIIAGAKKYIYIQMPYLIPEESILEAL
                     IIAANSGIDVRIMVPCMPDHPFVYRATEYYAKYLVAHGVKVYKYNDGFIHAKTMVSGSN
                     ISSVGSANQDFRSYTLNFEVNSFNYNPALTQELKKIFEKDLDKCTLLTNDYFAQQSSWL
                     KFKQYFSRLLSPIFNEKPSIGLSDGGFTLYLKNAVLFLYLFFISYIAMITIKK"
     CDS             complement(5409..5894)
                     /locus_tag="ctg19_13"
                     /transl_table=11
                     /translation="LRLLYGRSLEVAAALLQLGHGWLVLTVLPGIGFILYLFFGRQLSP
                     DEIFAIQEEQKKVQRHYLAEQRDMLKEYDLLPEKECLPRVRMLSELNLNNDDAILTFDN
                     QVKVFISGPELFDQMITDIKNAKKSVSLEFYTFYSDQLGHRVLKALEEAAVNGAKVE"
     CDS             6107..6604
                     /locus_tag="ctg19_14"
                     /transl_table=11
                     /translation="MRKQIISAAGIMLAVIGLGAATTQSVDAAVTNPVRQGKRLNLTRN
                     ATVYNRHGVKVGHLRKGKLYKVRAIKVINGNTYVKIRKNRFVKEEAFLPYMKSTVKVVN
                     RIKKHSFVYDENGEKIPGKFLKRGAEVNYLGHKEINKKPFIKIADGEYVKALNVLTTVT
                     NH"
     CDS             complement(6672..8945)
                     /locus_tag="ctg19_15"
                     /transl_table=11
                     /translation="MSEKFHGLTQAEADKRLKKDGLNEVPEPEYNFFKEFLSKLWNLSA
                     WILEGALILECILGKWIQSLFVLLMLLFAAFNGASKKKQSRRVLNTISHKLTPKVAVER
                     DGKWIKIDSKQLVRGDLISLQRGDVLAADVKMVSGKIACDESSITGESKPVKKNIDDTA
                     YAGTTVVEGDGLAIVTATGKDSRSGKTINLINNSAAPGHLQQLLTKIIYYLCLLDGVLT
                     LVIIIASFFKGGNFDTFINMLPFLAMMFIASIPVAMPSTFALSNSFEATRLSKEGVLTA
                     DLTGIQDAANLNLLLLDKTGTITENKTAVASWSDLSDLSDKDVLALAGSATDKRNAGII
                     DIAIDEYLKENNIPVMDVEHFTPFTSDTGYSMAEVDGHNVKLGSFKQLSLIDKNANEAV
                     EGINFKAGRSVAVLIDDKLAGVFILQDKVRKDSKAALAELKKRGVRPIMLTGDNQRTAA
                     AVAEQVDLTGNVISIHDFDESTDIDELAGIADVLPEDKLKMVKFFQEKGYIVGMTGDGV
                     NDSPALKQAEVGIAVSNAADVAKRSSKMVLLDDGLSSIVKILDAGHRVYQRMTTWSLTK
                     LARTAELTMLLTFGYLFFNYIPMALNAMVIYTIMNNMVTMMIGTDRTHITYKPENWNMA
                     RLAKIAFSLAAGWTVIGIAFISYLNMHGWSHNSISTMVYVYLVLSAMLIVLITRTRKYF
                     WQDYPSKLVGIVQIADVALTFILALCGLAMAQISWQNLLITVVVALIAAIIIDLIYQPV
                     MKNR"
     CDS             9074..9928
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     77.3; E-value: 2.1e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg19_16"
                     /sec_met_domain="LysR_substrate (E-value: 4.8e-30,
                     bitscore: 95.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 7.9e-25, bitscore: 77.3,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKQLRYFLVVAEEKQITSAAKRLYIAQPPLSYQLKQLERELGA
                     QLFKRTAHGMELTDAGQILQSYASEILSLSESVKNQVHKTISGELGTIAIGMASSSTGL
                     IPMKSFQDLTKFYPEINFDIYEDNTFGIIDKLEKKTIDLGIVRTPYNRNGLNAKTLTTE
                     RMMAVTVDPKFKDKTELRIKDLNEQPLIIYRRFEEIFNQTFAHHGIKPFYAVKCDDSRT
                     AITWAKRKMGIALVPESIASTYAPDDLLPIKHSNWITHLQLVWRKDQKVTPLMKRIIDS
                     LSR"
     CDS             10001..11230
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: Amidinotransf"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_17"
                     /sec_met_domain="Amidinotransf (E-value: 2.3e-105,
                     bitscore: 342.9, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLIHVYSEIGKLKTVMLHRPGRELENLSPDILNRMLIDDIPYL
                     KIAQKEHDYFAHTLEKQGVHVVYLEDLLAQSLTNEDVRTKFVDQLLEESNIKKEDPLHQ
                     LLMDYLMAMPVNEMVKQIIAGIRKNEIQNATPSLADLAEDPDYPFYLDPMPNVYFTRDQ
                     QAAIGNGMTINRMTFRARKRESLFMETVLKHHPDLKNANIPIWRDRYTHGRLEGGDELI
                     LNNHVLAIGISQRTSAAAITDLAHSLFGHSSYDTILAIKIPHNHAMIHLDTVFTMINYD
                     QFTVHPFILDKSGKIDIYVLEQDDHGEIKITPETDLIKVLKNYLHLSEIDLIPTGGGDA
                     IAAPREQWNDGSNTLAIAPGEVVTYDRNYVSNDLLRKHGILVHEIHSSELSRGPGGPRC
                     MSCPLVREDL"
     CDS             11242..12282
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_18"
                     /sec_met_domain="OTCace (E-value: 1.3e-50, bitscore: 162.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 2e-48, bitscore: 154.8,
                     seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLQNVFQGRSLLKCKDYTPAELNYLIDFALHLKELKKENIPHE
                     YLKGKNIALLFEKSSTRTRSAFVVACNDLGANPEYMGAGEIHLGKKESIEDTAKVLGSM
                     FDGIEYRGFAQKDVEDLAKYSGVPVWNGLTDKWHPTQMLADFMTIKEKFGHLKGLTLAY
                     VGDGRDNVADSLLVAGSMLGVNVHIVTPKPLFTHPDVQKIAGGFAKDSGSRNLITDDIE
                     QGVKGANIIYTDVWVSMGENDWSERIKLLMPYTVTMKMMHMTGTPDDHLIFMHCLPAFH
                     DCTTKVGEEIYEKYGLSEMEVTDEVFNSQYAWQFTEAENRLHSIKAIMAATLGNLFIPS
                     VDEGSK"
     CDS             12285..13217
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Arginine2_Hcarbonate: AA_kinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_19"
                     /sec_met_domain="AA_kinase (E-value: 6.5e-38, bitscore:
                     121.2, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVVALGGNAIEAGDNSAAAQEKQVEKTMKVVAKMIENGDQVA
                     IVHGNGPQVGNLLLQQYKGSSKDNPAMPLDTVVAMTQGSIGYWMQKALDDQFKHTNYPH
                     QAVALITQIIVNANDPAFKNPTKPIGPFYTFNEMQKQKIYHPEYTYKQDAGRGYRQVVS
                     SPKPVKIINAPVIDTLLKSKFVPIAAGGGGIPVVVKDDSLQGVAGVIDKDFSAAKLAED
                     IQADELVILTTVDNAYVNYNQPDQAPIGKIKIDQLKKYLEAGQFAAGSMKPKIEAVIDF
                     VEKKGKTAIITSLRNASKLDDGVGTIVYN"
     CDS             13234..13584
                     /locus_tag="ctg19_20"
                     /transl_table=11
                     /translation="MNIFQEGNPQNIAQVLAGKDYRVALQQAIFKKYPDATLVDINLNI
                     PGPIKNNRYLIKLFDYGIKQLEEIWQNKGYDYKLVKALNNDAGCENFYVLRESSKVVKL
                     STILFEENNKIG"
     CDS             13891..15057
                     /locus_tag="ctg19_21"
                     /transl_table=11
                     /translation="MKLKKNQDNLKQIASLIEYAFLKDSDLTTDSNFMTRYDHSDGYGY
                     FDQEKLTSYMMVNKFKAEIFGHHVPVAGIGYVASYPEYRGRGHISKLMKEILFDLHDQK
                     IPVANLAPFSEKFYRHYGFSNSIYQKEYRFSGAALASFRLPRKGKIIRGKWNDLIVQNG
                     VIQLYERQLHTDDERNTIIREAWWWNRLDDYYHHREIAVYFDEAGRPMSYLIYRIIDNC
                     FMADELYSITPQGLLSILGFMAVHIGSIKEFCMTLPGKSLLAELFPEQNELDIQLHPYM
                     MSRIIDFQKVLSCMRPLQGGTFNIEVNYDDQCPWNIGVWQLTNYDHQVKCERKEDELVD
                     FSGPITTWTQILLGRLTMESAIKFGLITDYRIKKLDFVKGKVSFYDYF"
     CDS             15073..15234
                     /locus_tag="ctg19_22"
                     /transl_table=11
                     /translation="MSKQKKVRLLKFLSVVVSGINVVISLLIMLNKYQIRKDKKQIADE
                     SHAPLDEN"
     CDS             15237..15842
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_23"
                     /sec_met_domain="LysR_substrate (E-value: 6.4e-19,
                     bitscore: 58.7, seeds: 361, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRIAYFNQLGRRQLDRIVDQFKQKHSDVEIELIGMGHDEAFD
                     KLAKNEVDLAISDLRDDQLDFKKEILGQEAVMAILQKGSYPSGVQMINKDDLADLTCFI
                     VAKPEEEAAELHLFKDIYQIRSPFIASNSVEEAALLVASGSGYFLMNETTASLISNDTL
                     QRLFLLSNGQQMWQKIAAFYTNEDAVIKDFILLAKKVY"
ORIGIN
        1 gaagttgaat acgctaaagg acatggcgtg gatactatta ttacggatca ccatactttt
       61 caagaaaata agccagatgc ttatgcaatt gttcactgta attatccggg tcaagaatat
      121 ccttttgatg attattgtgg tgcaggtgta gcttatacga tttgtcgtga gcttatgcag
      181 gatcctgtac cagaattgct agatttagca atgatcggta ctattggtga catggttaaa
      241 gttactggtg aaggccatat tattgtaaaa cgtgggttag atgttcttaa tcaaaccgaa
      301 cgaccgggct taagagcgct tatcaaaaat gccggtttaa cgctagaaac gattaatgag
      361 acagatatag gctttaatat tgctcctaga cttaatgctg tgggacgttt ggctaatgct
      421 aatctggcag tagagctttt gcttagtgat gatgatcttg aggcacagaa gatcgcagat
      481 cagattgaag acttaaataa taagcgtaaa gagctaacta ctgaggttta cgatcgctgc
      541 atggaattag ttcatgaaaa tagttggcaa aagcaaaata ctttagtttt atatgatcct
      601 gattttcatg aaggagtttt ggggcttgtt gctaacaaga tagtggaaaa actgcataaa
      661 ccaacaattg ttttaactaa aaacgatgaa ggggagatta agggatcagg tcgttcattc
      721 agtggtttta acttatttga tgctcttaat ccgttaaaag aaagtctatt gaccaaattt
      781 ggaggtcatg attttgcttg tggtttatcc atggaagaag ataaagtaaa tgacctacgg
      841 gaaaagtttg aagccgattt tcatgttgac agtggtttag agactaaaga gtacgatatg
      901 gaattgccta tgcatgactt atcacctcaa actttggctc aaattaatca agtgggacca
      961 tttggtactg gtgatccgca gccaattttt agtatttcgg atccaactat tacacacttt
     1021 ttcaaaatag gaaaagataa gaatcatgtt aaattaacag ctaataaaaa agacggcaat
     1081 ttagcaattg tgggatttaa taaggattat ttgaataata atttgttacc atttatttca
     1141 aaaatctttg ttactctctc tttgaatact tatcgcaaac aagtatcttt gcaaggcatc
     1201 atggaaggaa tagcttttgc atcccccaaa ttagctatgc caacatcagt aattgattta
     1261 agacaagaga aatttgtcat gggctttgca gatcgttatt tgctttttga caaaaagaat
     1321 attccaattg ttaagaattg ccttcaaatt gatgatgata aaattagctt ggttaaagat
     1381 tatgatcaat cgggtgaaac agtagctttg cttgatgtgc ctcgcaatca agtggaatta
     1441 aatgcagctt tagaaaaaga ttatcaacaa atttatttac gctttttatt agatcagtta
     1501 cctgttgaac atattccagc aaagagttat ttcggaaaag tgttaaagta tatttatgcc
     1561 catccagcat taaagcctga agactattgc actgtagcac catatctagg tttggattat
     1621 gatagtgtat tgtttatttt gcgagtattc tttgaattag gttttgttaa attagatgat
     1681 caaaaattag ttggtgagtc taatccaaag aagcaaccat tgacagcttc taaatattta
     1741 atggtaacga gttcacaaat taaatttatt aatcaactaa gaacgatacc tactcaaaaa
     1801 ttaattacat atattaataa tttggtaaaa aggtagataa atatcaagat ttcagtgctt
     1861 ttataacaaa tctttggtaa aatatacaag tcaaaagtgt ttgaatacaa acgcacagaa
     1921 ttatggaggt ttttcttctt atggcgattg attttagtaa atatattgca agtgttaagg
     1981 actttcctaa taagggaatt gtctttcgcg atattacacc tattttgcaa gatggtgaat
     2041 tgtatcgtgc tgctactcat gaattggcag aatatgcaaa gagtagaaag gcagatataa
     2101 ttgtaggtcc tgaagcacgt ggctttattg taggctgtcc tgttgcaact gagttaggct
     2161 taggttttgt tccagcaaga aagccacata agttgccaag agaagttgaa cgtgcttcat
     2221 atgacttgga atacggttca aatagccttg agatgcataa agatgcaatt aagcctggcc
     2281 aaagagttgt tctctgtgac gatttaatgg ctactgcagg tactttaaga gcttctaaga
     2341 aattaatcga aaatcttggt ggtaagcttg taggtgctgc attttacatt gaattgcctg
     2401 atttaaaggg tagagaaaag ttgcctgatg ttgatattta cagcttagtg caatatcatg
     2461 gtgcttaaat aaattcaata ttgatctaat tagtaaaggt cattatacta aaagtgttgt
     2521 accagcattg actggtgcac aatcaacaga aataaaaata atactcctaa ggaaattttc
     2581 cttaggagta tttgtttaca gaaattaagt tttaagcatt aaataatgca gttgaaaggt
     2641 aacgatcatc gccgtctgga actacagtaa tcacagcatg tcccttgcct aactttttag
     2701 caatttcgat tgcaccatgg atgtttgcac cagctgaaat accaggtaag aagccttcgt
     2761 ttttagctac ttcacgagct gtagccattg cttcatcagt agaaactgta attatatcat
     2821 cgtagatatt tatctaaatt cttagggatg aaacctgcgg caataccttg gataccatgt
     2881 ttacctgttt ttccatcttt taagagtgga gattcagttg gctcaagtgc aaatatctta
     2941 gtggatgaat tttcacgcct aagtgcatgt ccaattcctg ataaagtacc accagtatca
     3001 ataccagcaa caaaggcatc aacggatttg ctgataccat tcattgcggc aataatttct
     3061 ggaccagtag ttaattcatg aatattagga ttttctgtat tttcaaattg cattggcatg
     3121 aagtagcctt tttctttaac taattcttcg gccttagcaa ttgaaccttt cataccgtct
     3181 gcacctggtg tcaaaatgag ttcagcacca tagcccttca ttaatttacg acgctcaaca
     3241 ctcatagttt ctggcataac aataataatg tgatagccct tagctgcagc aaccatggct
     3301 aaaccgatac cggtattgcc tgaagtaggt tctacaattg tgccacctgg ctttaagttg
     3361 ccttaacgtt cagctttttt gatcatagct aaagcaattc tgtctttaat tgaaccagct
     3421 ggattttcaa attccaactt tacatagaca tctgccgcgt cgtcaggtac aacgcgattc
     3481 aacttaagta atggagtgtt gccgataagt tctgtaactg aattataaat tgtagacata
     3541 atgtatacct cgttttattt atctaataat actaatttgc tttttttaac ttgggttagc
     3601 cagttattga aaaatgtttt ctgagtatct ttccattgaa acaatggatt tgataatgaa
     3661 taattttctg gcttcttata atgtcgctct ggatgtgcag caatctctct ttcatattct
     3721 tttttaaggc cttttcggcc gtattcgata tgagagaaaa taaaattttg ctcaggcttt
     3781 tctaaagaag agaccataaa tagatgccca ttatcgtcaa ctgaattaat ggttaatcgt
     3841 ggatcttgca taatctgtgt tttatccatt tcagcgtaac gagcatgtgg agcgataaat
     3901 ccttggctga gaccatttaa taaaggatgt ggttcgataa ttaaatgagg aaaaacacca
     3961 aagatttttt tgaatattgt aaaaataatc taaagcggcc attgcacccc agcaaaaata
     4021 taattgctgc aacttgtatt tatctaatag ttggagcaaa catcggactt cctcgatgta
     4081 ggtaacttga tcaaaatcaa gatgatctaa aggtgcgccc gtaatgataa agccatcaaa
     4141 ctctttgatt cgattaagat ctaatggcta ggaagttttt gcaacttcag gtgggacagg
     4201 acgattttga taatgcatac gtggataaaa gaaagtcagg tctgcatctg gcaaaacgcg
     4261 tgcaaatctt tgttgagtat ctaacttatc gtgcattaaa ttcaaaacgc ctatttttac
     4321 tctattagcc aagttttatc ctccttactt tttaatagtt atcattgcta tataacttat
     4381 aaaaaataag taaagaaata aaactgcatt ttttaaatac aaagtaaaac ccccatcgga
     4441 tagaccgata gagggctttt cattaaaaat aggtgataat aatcttgaga agtattgctt
     4501 aaattttaac catgatgatt gttgagcaaa gtagtcatta gttaaaaggg tacatttatc
     4561 taagtccttc tcaaaaattt tctttaattc ttgagttaaa gcagggttgt agttgaatga
     4621 gtttacctca aagtttaatg tatagcttcg aaaatcttga ttggcggaac caactgaaga
     4681 aatattagaa ccgctaacca tagtttttgc atgaataaaa ccatcattat atttgtatac
     4741 tttaacgcca tgggctacta aatacttagc ataatattct gtagcacgat aaacaaatgg
     4801 atgatcgggc atgcaaggaa ccataattcg aacatcaata ccgctgttag cagcgataat
     4861 taaggcttca agaattgatt cttcaggaat taaataaggc atttgaatat aaatgtattt
     4921 tttagctcct gcaataattc cttcatagcc tcgtctgatg ccgtaatgtt gattatcagg
     4981 tcctgagtaa acaatttgca tagcgacatt tttattatca ttgatatctt ttcgattgac
     5041 agtaaatggt ttaagttcct ttaattcaaa tttaggtaaa tttgttcttc tgattgacgt
     5101 gttccagtcc attgcaaacc ggacctccat tagaattggc gattgcccaa ttacacgtaa
     5161 atgggtatcc cgccaatgac cgaattttgg tgatttattg acatattgat ctccaatatt
     5221 aaatccgcca atatagctaa tatggtggtc aataataact aattttctat gtaagtggta
     5281 attgagtcgt ggggtagtaa accagtgctt ttttgaagtg gaaataaatg gttgagcttc
     5341 gccgctcaat tctcttaaat ggtcacaaaa gcttggctta gtgcctcttg atccagaggt
     5401 atcataaatt actctacctt agcaccatta actgcagcct cttccaaggc ttttaaaaca
     5461 cgatgcccta attggtcaga ataaaaagta taaaattcta agctgacgga ttttttggca
     5521 tttttgatat cagtaatcat ttggtcaaaa agttctggtc cagaaataaa aactttgacc
     5581 tgattatcaa aagttaaaat cgcatcatcg ttgttaagat ttagttccga aagcattctt
     5641 actcgtggaa gacactcttt ttcaggtaga agatcgtact ctttaagcat gtcgcgttgc
     5701 tcagctaaat aatgtctttg tacctttttt tgctcttctt gaatagcaaa gatttcatca
     5761 ggtgaaagct gacgaccaaa gaaaagatat aggataaaac caataccggg cagaacggtt
     5821 aatacaagcc atccatgccc aagttgcaac aacgctgcgg cgacttctaa agaccgtcca
     5881 tacagcaaac gcaatattga taatccataa gacttcgata gtcctacgga ttatatccca
     5941 agttaaaatc atgaataatt actcccttgt aagtagtgtt ataaataatt ttagcagaat
     6001 taagcaaata gttataaaac agatgagtaa aaaatgcttc caattcgata atttttgata
     6061 aaataaggga tgaagaatgg tataaacact acgggggtgg attatgatga gaaaacaaat
     6121 tatttctgct gcaggtataa tgttagcagt tattggatta ggcgcagcaa ctacacaaag
     6181 cgttgatgca gctgttacta atccagttag acaaggtaag agattaaatc taactagaaa
     6241 tgctactgtt tataatagac atggtgttaa agttggacat ttaagaaagg gaaagcttta
     6301 caaagtacgt gccataaaag taattaatgg taatacttat gtaaagattc gtaaaaatag
     6361 atttgttaag gaagaagcct tcttgccata tatgaagtct actgtaaaag tagttaatag
     6421 aatcaaaaag cattcctttg tttatgatga gaatggtgaa aaaatcccag gcaaattttt
     6481 aaagcgtggt gctgaggtta actatttagg ccataaagaa attaataaaa aaccatttat
     6541 caaaattgct gatggtgaat atgttaaggc tttgaatgtc ttgactacag ttactaatca
     6601 ttaatcaaaa aaacactctg aaaactacat tgtagtaatg tagttttcag agtgtttttg
     6661 ttttaagtta attatctgtt tttcattact ggttgataaa tcaaatcaat aataattgct
     6721 gcaattaatg caaccacaac ggtaattaat aagttttgcc aactaatttg agccattgct
     6781 aaaccgcata aagctaaaat aaaggttaat gcgacatcgg caatttgaac aatacctaca
     6841 agtttagatg ggtaatcttg ccagaagtat ttacgagttc tagtaattaa tacaattaac
     6901 attgcactta gaactaagta aacatagacc atggtagaga tagaattgtg actccagcca
     6961 tgcatgttga ggtagctgat aaaagcgata ccgataactg tccaacctgc agcaagagag
     7021 aatgcgattt tggctaacct tgccatattc caattttctg gtttgtaagt aatatgggta
     7081 cggtcagtac caatcatcat ggtaaccatg ttattcatga ttgtgtaaat aaccatagca
     7141 tttaatgcca ttggaatata gttgaagaag agatagccga aggttaaaag catagttaat
     7201 tcggcggttc tggcgagctt agtaagtgac caagtagtca tccgttgata tacacggtga
     7261 ccagcatcaa gaattttaac aatagagctt aagccatcat ctagaagcac catcttactt
     7321 gaacgcttgg caacatcggc agcgttagaa acagcaatac caacttcagc ttgctttaaa
     7381 gcaggagagt cgttaacacc atcaccagtc ataccaacga tataaccttt ttcttggaag
     7441 aatttaacca tcttaagttt atcttcaggt aaaacatcgg caatccctgc taattcatca
     7501 atatcggtgc tttcatcaaa gtcatgaata gagataacgt taccagttaa atcaacttgt
     7561 tcagcgactg ctgcggcagt tctttgatta tcaccagtta acatgattgg acgtacgccc
     7621 cgttttttaa gttctgctaa agcagcctta gagtcctttc ttactttatc ttgtaagata
     7681 aatactcccg caagtttgtc atcaattaac acggcaactg agcgtccagc tttaaaattg
     7741 atgccttcaa ctgcttcatt tgcattctta tcgattaatg aaagttgctt aaatgaacct
     7801 aacttaacat tgtgaccatc tacttcagcc atagaatagc cagtgtcaga agtaaatggg
     7861 gtaaagtgtt caacgtccat gacagggata ttgttttctt ttaagtattc atcaatggcg
     7921 atatcaatga tacctgcatt acgcttatca gttgcactac cggctaaagc aagtacatct
     7981 ttatctgaca aatcgcttaa atcgctccaa ctagcaactg cagttttgtt ttcagtgatt
     8041 gttcccgtct tatcaagtaa aagcaagttt aagttagctg catcttggat accagttaaa
     8101 tcagctgtta agacgccttc tttacttaaa cgggttgctt caaatgaatt ggacaatgca
     8161 aaggttgacg gcatcgcaac cggaattgaa gcgatgaaca tcatggctaa gaatggcaac
     8221 atgttgataa acgtatcaaa attaccaccc ttaaagaatg aagcaatgat aataactaag
     8281 gtaagtacac cgtcaagtag gcaaaggtag taaataatct tagttaaaag ctgttgcaag
     8341 tgaccaggtg cagctgaatt gttgatcaag ttaatggtct taccacttct tgaatcttta
     8401 ccagttgcag taacaattgc taatccatcg ccttcaacaa cagtagtacc agcataagct
     8461 gtgtcatcaa tgttcttttt aacgggcttg gattcaccgg taattgagct ttcatcacag
     8521 gcgatcttac cgctaaccat ttttacatcg gctgcaagta catccccacg ttgaagtgag
     8581 attaagtcac ctctaactaa ttgcttagag tcaattttga tccacttacc atcgcgttct
     8641 acagccacct taggggttag cttatgtgaa atggtattta atacccgccg tgactgtttc
     8701 ttcttggatg caccgttaaa agccgcaaaa agaagcatca acaagacgaa caaagattga
     8761 atccatttgc ctaagataca ttcgaggatt aaggcacctt ctagaatcca ggcagaaaga
     8821 ttccataatt ttgatagaaa ttccttaaaa aagttgtatt cgggttcagg tacttcgttt
     8881 aacccatctt ttttaagtct cttatctgct tcggcttgag ttaagccatg aaatttttca
     8941 gacattttat tccctccaaa tctaccttaa taaagtagca catatgttgt ttgaatgaaa
     9001 atactaaatt aaaatataag atatagaaat ttttaataag agatacaact aaaataaaaa
     9061 ggatagatta ttaatgaata ttaaacaatt acgctacttt ttagtagtag ccgaagaaaa
     9121 gcaaatcact tcagcagcta aaagactata cattgcacaa ccgccgctga gttatcaatt
     9181 aaagcaacta gaaagagaac taggagcaca attatttaag cgtactgctc atggaatgga
     9241 attaacagat gctggacaaa ttttgcagag ctatgctagt gaaattctct ctttatcaga
     9301 aagcgtgaaa aatcaggttc ataaaactat ttcaggtgaa ctaggcacga ttgcaatagg
     9361 catggcttca tcatcaactg gactaattcc tatgaaaagt tttcaagatt taactaagtt
     9421 ttatccggaa atcaactttg atatttatga agataatacc tttggcatta tcgataaatt
     9481 ggaaaagaag acaatcgatt taggaattgt gcgtacgcct tataatcgta atggcttaaa
     9541 tgcaaaaact ttaactactg aaagaatgat ggcagttact gttgatccca aatttaagga
     9601 taagacggaa ttaaggatta aagatctaaa tgagcagccc ctcattattt atcgaagatt
     9661 tgaagaaatt tttaaccaga cttttgctca tcatgggatt aagccgtttt atgctgttaa
     9721 atgtgatgat tctagaacag cgattacttg ggcgaagaga aaaatgggga ttgctcttgt
     9781 tcctgaatct attgcttcta cgtatgcacc tgatgatctt cttcctatta aacatagtaa
     9841 ttggattacg catttgcaat tagtgtggcg caaggatcaa aaggtgacgc ctttaatgaa
     9901 aagaataata gattcactaa gccgttaaga ttgtaacttc tacctaattg atccataatt
     9961 attgtaaaca aatacataat ttgaattagg agactatata atgactgact taattcatgt
    10021 ttattccgaa attggcaaat taaaaacagt tatgctgcat cgaccgggaa gagaattaga
    10081 aaatctttca ccagatatct taaatcgaat gttaattgac gatattccat atttaaaaat
    10141 agctcaaaaa gagcatgatt attttgccca cactttggaa aaacagggag ttcatgttgt
    10201 ttatttagaa gatttactag ctcagtcttt gactaatgaa gatgtccgta caaaatttgt
    10261 ggatcaatta ttagaagaat ccaatataaa aaaagaagat ccattacatc aattactgat
    10321 ggactattta atggcaatgc cagtaaatga aatggttaag caaataattg ctggtattag
    10381 aaaaaatgaa atacaaaatg caactccttc attagccgat ctagctgaag atccagatta
    10441 tccattttat ttggatccaa tgccaaatgt gtattttact cgtgatcaac aagcagctat
    10501 tggtaatggc atgactatta atagaatgac atttagagct agaaaacgtg agtcattatt
    10561 tatggaaacc gttttaaagc atcatcccga cttaaaaaat gccaatattc ctatttggcg
    10621 tgatcgttac acccatggac gtttagaagg tggcgatgag ctgattttaa acaatcatgt
    10681 tttagcaatc ggtatttctc aaagaacttc cgctgccgca atcactgacc ttgctcatag
    10741 cctgtttggt cattctagtt atgacacaat tttagcaatt aaaataccac ataatcatgc
    10801 catgatacat ctggatacag tctttacaat gattaattat gatcagttta ccgttcatcc
    10861 ttttatttta gacaaatcag gaaagattga tatttatgtt ttagagcaag atgatcatgg
    10921 tgagattaaa attaccccag aaactgattt gatcaaagtg ttaaagaatt atttgcactt
    10981 atcggagatt gacctaattc caaccggagg tggggatgca attgcagccc caagagagca
    11041 gtggaatgat ggctcgaata ctttggctat tgcgccaggt gaagtcgtta catatgatcg
    11101 taattatgta tcaaatgatt tgttaagaaa gcatggcatt ttagttcatg aaattcattc
    11161 aagtgagctt tctcgtggcc ctggaggtcc aagatgtatg tcatgtccac ttgttcgtga
    11221 agatttgtaa gaggcgtcaa aatgaaatat ttacaaaatg tatttcaagg cagaagttta
    11281 ttaaaatgca aagactatac tccagcggag cttaactatc taattgattt cgcacttcat
    11341 ttgaaggaac taaagaaaga aaatattccg catgaatatt taaaaggaaa gaatatagct
    11401 cttttatttg aaaaatcttc aacaagaaca cgttcagcct ttgtagttgc atgcaatgat
    11461 ttaggcgcaa atcctgaata tatgggtgct ggtgaaattc atttaggtaa aaaggaaagt
    11521 attgaagata ctgcaaaggt tttgggcagt atgtttgacg gcattgaata tcgcggtttt
    11581 gctcaaaaag atgtagaaga tttggctaaa tattctggtg tccctgtttg gaatggttta
    11641 acagataaat ggcatccgac ccaaatgttg gctgacttta tgactattaa agaaaagttt
    11701 ggacatttaa agggacttac tttagcttat gtaggcgatg gacgtgataa tgttgccgac
    11761 agtcttttag tggctggcag catgcttgga gttaatgtac acatagttac gcccaagcct
    11821 ttattcactc accctgatgt acaaaaaatt gcaggaggtt ttgccaaaga ttctggatca
    11881 agaaatttga ttactgatga cattgaacaa ggcgttaaag gtgcaaatat tatttatact
    11941 gatgtctggg tatcaatggg tgaaaatgac tggagtgaga gaatcaaatt gttaatgcct
    12001 tacacggtta caatgaagat gatgcatatg acaggcaccc cagatgatca tctaatcttt
    12061 atgcactgtt tgcctgcgtt tcatgattgc actactaaag ttggcgaaga aatttatgaa
    12121 aaatatggtc taagtgaaat ggaagtgaca gatgaagtct ttaactctca atacgcttgg
    12181 caatttactg aagcggaaaa tagattgcat tctatcaaag caataatggc cgctactttg
    12241 ggcaatttgt ttattccgtc agttgatgaa ggaagtaaat aaagatgaaa agaatagttg
    12301 tagctttggg tggcaatgct attgaagcgg gtgataatag tgcagctgcc caagaaaagc
    12361 aggttgaaaa gacaatgaag gttgttgcta aaatgattga aaatggtgat caggtagcga
    12421 ttgttcatgg taatggcccg caggttggta atttgctttt gcaacaatac aaaggttcaa
    12481 gtaaagataa tcccgctatg ccgcttgata cagtagtagc aatgactcaa ggcagtatcg
    12541 gctattggat gcaaaaggcc ttagacgatc aatttaaaca tacaaattat ccacatcaag
    12601 ctgttgcttt gattactcag ataatagtta atgcgaatga tccagctttt aagaatccaa
    12661 ctaaaccaat tggcccattt tatacattta acgaaatgca gaagcaaaaa atctatcatc
    12721 ctgaatatac ttataagcaa gatgcaggtc gaggctatcg tcaagtagtt tcttctccaa
    12781 agcccgttaa aattattaat gcaccagtca ttgacacttt actaaagagc aagtttgttc
    12841 ctattgctgc cggaggtggt ggaattcctg ttgtagtgaa agacgatagt ttgcaaggcg
    12901 tagcaggagt aattgataaa gacttcagtg ccgcaaaact agctgaagat attcaagcag
    12961 atgaactagt tattctaact actgttgaca atgcctacgt gaactataat caacctgatc
    13021 aagctcctat tggaaaaata aagattgatc aattaaagaa gtatctagaa gctggccaat
    13081 ttgccgcagg cagcatgaag ccaaaaattg aagctgtcat tgatttcgta gagaaaaaag
    13141 gaaagactgc aattattact tctttaagaa atgcaagtaa acttgatgat ggagtaggta
    13201 caatcgttta taattaactg cggtgagata taaatgaaca tttttcaaga aggaaatccg
    13261 caaaatattg ctcaggtatt agctggaaaa gattatcgtg tagctttgca gcaagctatt
    13321 tttaaaaagt atcctgatgc gactttggtt gatataaact taaatatccc agggccaatt
    13381 aaaaataatc gatatttaat caaattattt gattacggaa ttaaacaatt agaagaaata
    13441 tggcagaata agggatatga ctataaatta gtaaaagcat taaataatga tgctggatgt
    13501 gaaaatttct atgttttgcg agaatctagc aaagtagtta aattatctac aattttattt
    13561 gaagaaaata ataaaatagg atgattattt gatgccgatg tattaattaa aggaagaact
    13621 gcactttcac gccaagagct tgaatactct agtcgccgct gctatttatg caatcgccct
    13681 gctaaagagt gtgctcgatc acggcgacac tcagtagaag agatgcaaag atacatttct
    13741 agtttatatg cgaagtatgt aaataattaa aacgggatgg gaggctaatc atcctgtttt
    13801 ttcatttaaa tcttaaaaaa agctaacgaa aaatacataa aatgttctaa aatataagtg
    13861 aagttatgaa tatatattgt aaggaaaact atgaaattaa agaaaaacca agacaattta
    13921 aaacaaattg cttcattgat tgaatatgct tttttaaaag attctgattt gactacagat
    13981 agtaacttta tgacccgata tgatcatagt gatggatatg gatattttga tcaagaaaaa
    14041 ttgaccagtt atatgatggt caataagttt aaagctgaga tatttggtca tcatgttcca
    14101 gtggcaggta ttggttatgt ggcatcatat cctgaatata gaggacgtgg acatatatct
    14161 aaattaatga aagaaattct ttttgatttg catgatcaaa aaatcccagt tgcaaatcta
    14221 gctccatttt cagaaaaatt ttatcgtcat tatggtttta gcaatagtat ttaccaaaaa
    14281 gaatatcgct tttcgggggc tgcacttgct tctttcagat taccacgcaa aggtaagata
    14341 attcgtggaa aatggaatga tttgattgtt caaaatggtg tgattcaatt atatgaacgt
    14401 cagttgcata ctgacgatga aagaaatacg attatcagag aagcttggtg gtggaataga
    14461 ttagatgatt attatcatca tcgagagatt gctgtttact tcgatgaagc tggtcggccg
    14521 atgagctact tgatttatcg cataattgat aactgtttta tggctgatga attatattca
    14581 attacgcctc aaggattatt aagcatatta ggctttatgg cagttcatat agggtcaatt
    14641 aaagagtttt gtatgacatt gcctgggaag tctttattgg ctgaactttt tccagagcaa
    14701 aatgaattgg atattcaact tcatccatat atgatgagta gaattattga tttccaaaaa
    14761 gtcttgtcat gcatgcgccc attgcaaggg ggtactttta acatcgaggt taattatgat
    14821 gatcagtgtc catggaatat tggcgtttgg caattaacta attatgatca ccaagttaag
    14881 tgtgaacgaa aagaagatga actagttgat ttctctggtc caattacaac atggactcaa
    14941 atcttattag gacgtttaac tatggaatcc gcaattaaat ttggtttgat cacagattat
    15001 cgaattaaaa agttggactt tgtaaaaggt aaagtctcat tttatgatta tttttagaag
    15061 aaggtatcca aaatgagtaa gcaaaagaaa gttagattac taaaattttt aagcgtggta
    15121 gttagtggaa taaatgtggt tatttcgcta ttgattatgc tcaacaaata tcaaattaga
    15181 aaagataaaa aacaaatagc agatgaaagt catgccccat tggatgaaaa ttaactatga
    15241 aaaaattgag aatagcatac tttaaccaac ttggtagaag acaattagat cgaattgtag
    15301 accaatttaa gcaaaaacat tctgatgtag aaattgaatt aattggaatg ggacacgatg
    15361 aagcttttga taaattagcc aaaaatgaag ttgatttagc aattagtgat ttgcgtgatg
    15421 atcagctcga ttttaagaaa gaaatcttag gtcaggaagc agtaatggct attttgcaaa
    15481 agggtagtta tcctagcggt gttcagatga tcaataaaga tgatctagct gatttaacct
    15541 gttttattgt agctaagcct gaagaagagg ctgcagaact ccatttattt aaagatattt
    15601 atcagattag aagcccattc attgcttcaa attccgtaga agaggcagca ttgttagtag
    15661 cttctggatc aggatatttt ttaatgaatg aaacaaccgc cagtttaatt agtaatgata
    15721 ctttacaacg attgttttta ttgtctaatg gacaacaaat gtggcaaaag attgcagctt
    15781 tttataccaa tgaagatgca gtaattaaag attttatttt gttagctaaa aaagtatatt
    15841 aatctacgcg tggtgctagt taaatcgttc tagacaatat gccatattgt aagctaaaac
    15901 tgcaacttca agccgttcct gaaaacctgt tagactccga gcacgattat tttgagcgtt
    15961 gtaatagcta
//
