Select genomic region:
Overview
1.1
1.2
2.1
2.2
2.3
4.1
4.2
4.3
5.1
6.1
6.2
7.1
7.2
9.1
14.1
15.1

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaHKECNGDP_1 (original name was: gnl|Prokka|HKECNGDP_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRP-metallophore,NRPS,RiPP-like | 77,356 | 129,149 | bacillibactin | NRP | 100%
Region 1.2 | other | 652,422 | 693,840 | bacilysin | Other | 100%

gnlProkkaHKECNGDP_2 (original name was: gnl|Prokka|HKECNGDP_2)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | transAT-PKS | 88,275 | 176,508 | macrolactin H | Polyketide | 100%
Region 2.2 | terpene | 491,264 | 512,004 |
Region 2.3 | PKS-like | 594,778 | 636,022 | butirosin A/butirosin B | Saccharide | 7%

gnlProkkaHKECNGDP_4 (original name was: gnl|Prokka|HKECNGDP_4)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | transAT-PKS,T3PKS,NRPS | 132,777 | 242,882 | bacillaene | Polyketide+NRP | 100%
Region 4.2 | NRPS,transAT-PKS,betalactone | 302,758 | 440,601 | fengycin | NRP | 100%
Region 4.3 | terpene | 463,580 | 485,463 |

gnlProkkaHKECNGDP_5 (original name was: gnl|Prokka|HKECNGDP_5)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 5.1 | lanthipeptide-class-ii | 112,189 | 135,371 | mersacidin | RiPP:Lanthipeptide | 100%

gnlProkkaHKECNGDP_6 (original name was: gnl|Prokka|HKECNGDP_6)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 6.1 | NRPS | 1 | 58,235 | surfactin | NRP:Lipopeptide | 91%
Region 6.2 | NRPS,transAT-PKS | 136,691 | 214,421 | bacinapeptin | RiPP | 50%

gnlProkkaHKECNGDP_7 (original name was: gnl|Prokka|HKECNGDP_7)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 7.1 | transAT-PKS-like | 1 | 46,470 | difficidin | Polyketide | 53%
Region 7.2 | T3PKS | 162,411 | 203,511 |

gnlProkkaHKECNGDP_9 (original name was: gnl|Prokka|HKECNGDP_9)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | LAP,RRE-containing | 26,754 | 49,931 | plantazolicin | RiPP:LAP | 91%

gnlProkkaHKECNGDP_14 (original name was: gnl|Prokka|HKECNGDP_14)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 14.1 | transAT-PKS | 1 | 34,055 | difficidin | Polyketide | 46%

gnlProkkaHKECNGDP_15 (original name was: gnl|Prokka|HKECNGDP_15)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 15.1 | transAT-PKS-like | 1 | 23,013 | difficidin | Polyketide | 26%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRP-metallophore,NRPS,RiPP-like | 77,356 | 129,149 | bacillibactin | NRP | 100%
Region 1.2 | other | 652,422 | 693,840 | bacilysin | Other | 100%
Region 2.1 | transAT-PKS | 88,275 | 176,508 | macrolactin H | Polyketide | 100%
Region 2.2 | terpene | 491,264 | 512,004 |
Region 2.3 | PKS-like | 594,778 | 636,022 | butirosin A/butirosin B | Saccharide | 7%
Region 4.1 | transAT-PKS,T3PKS,NRPS | 132,777 | 242,882 | bacillaene | Polyketide+NRP | 100%
Region 4.2 | NRPS,transAT-PKS,betalactone | 302,758 | 440,601 | fengycin | NRP | 100%
Region 4.3 | terpene | 463,580 | 485,463 |
Region 5.1 | lanthipeptide-class-ii | 112,189 | 135,371 | mersacidin | RiPP:Lanthipeptide | 100%
Region 6.1 | NRPS | 1 | 58,235 | surfactin | NRP:Lipopeptide | 91%
Region 6.2 | NRPS,transAT-PKS | 136,691 | 214,421 | bacinapeptin | RiPP | 50%
Region 7.1 | transAT-PKS-like | 1 | 46,470 | difficidin | Polyketide | 53%
Region 7.2 | T3PKS | 162,411 | 203,511 |
Region 9.1 | LAP,RRE-containing | 26,754 | 49,931 | plantazolicin | RiPP:LAP | 91%
Region 14.1 | transAT-PKS | 1 | 34,055 | difficidin | Polyketide | 46%
Region 15.1 | transAT-PKS-like | 1 | 23,013 | difficidin | Polyketide | 26%

No secondary metabolite regions were found in these records:
  gnlProkkaHKECNGDP_3 (original name was: gnl|Prokka|HKECNGDP_3)
  gnlProkkaHKECNGDP_8 (original name was: gnl|Prokka|HKECNGDP_8)
  gnlProkkaHKECNGDP_10 (original name was: gnl|Prokka|HKECNGDP_10)
  gnlProkkaHKECNGDP_11 (original name was: gnl|Prokka|HKECNGDP_11)
  gnlProkkaHKECNGDP_12 (original name was: gnl|Prokka|HKECNGDP_12)
  gnlProkkaHKECNGDP_13 (original name was: gnl|Prokka|HKECNGDP_13)
  gnlProkkaHKECNGDP_16 (original name was: gnl|Prokka|HKECNGDP_16)
  gnlProkkaHKECNGDP_17 (original name was: gnl|Prokka|HKECNGDP_17)
  gnlProkkaHKECNGDP_18 (original name was: gnl|Prokka|HKECNGDP_18)
  gnlProkkaHKECNGDP_19 (original name was: gnl|Prokka|HKECNGDP_19)
  gnlProkkaHKECNGDP_20 (original name was: gnl|Prokka|HKECNGDP_20)
  gnlProkkaHKECNGDP_21 (original name was: gnl|Prokka|HKECNGDP_21)

Compact view
gnlProkkaHKECNGDP_1 - Region 1 - NRP-metallophore,NRPS,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 77,356 - 129,149 nt. (total: 51,794 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 77355 - 129149:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 77355 - 129091:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_102: Gly - Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (456..855): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGLIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGLIWK (97% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1513..1929): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg1_104: diOH-Bz
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): diOH-Bz
  nrpys: diOH-Bz
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Small clusters prediction:
      Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
    Single AA prediction:
      dhb (diOH-Bz)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PLPAQGVVNK
    Nearest Stachelhaus code(s):
      diOH-Bz PLPAQGVVNK (100% 8Å match)
      diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaHKECNGDP_1 - Region 2 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 652,422 - 693,840 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaHKECNGDP_2 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 88,275 - 176,508 nt. (total: 88,234 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 88274 - 176508:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  ctg2_110 + ctg2_109 + ctg2_108 + ctg2_107 + ctg2_106 + ctg2_105 + ctg2_104

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_111: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 75.0%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 91.9
    inactive: 31.2
    Methoxymalonyl-CoA: 26.1
    Methylmalonyl-CoA: 19.6
    Propionyl-CoA: 16.9
    fatty_acid: 13.9
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

gnlProkkaHKECNGDP_2 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 491,264 - 512,004 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaHKECNGDP_2 - Region 3 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 594,778 - 636,022 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
NRPS/PKS substrates
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

gnlProkkaHKECNGDP_4 - Region 1 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 132,777 - 242,882 nt. (total: 110,106 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 132776 - 242882:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_147: mal
  PKS_AT (4..285): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 87.5%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 100.2
    inactive: 46.7
    Methoxymalonyl-CoA: 38.4
    Methylmalonyl-CoA: 24.9
    Propionyl-CoA: 23.1
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_148: mal
  PKS_AT (7..293): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 35.4
    inactive: 26.4
    Methoxymalonyl-CoA: 14.9
    Benzoyl-CoA: 14.0
    Methylmalonyl-CoA: 9.2
    Isobutyryl-CoA: 8.8
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_149: mal
  PKS_AT (4..282): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 91.7%
    inactive: 66.7%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 92.5
    inactive: 29.1
    Methoxymalonyl-CoA: 23.3
    Methylmalonyl-CoA: 10.9
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_154: pk - Gly
  Search NORINE for peptide: strict or relaxed
  CAL_domain (74..476): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 26.7
    NH2: 9.4
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (1145..1540): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGMIWK
    Nearest Stachelhaus code(s):
      Gly DILQLGMIWK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_157: Ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (492..896): Ala
  nrpys: Ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVSNMAIIYK
    Nearest Stachelhaus code(s):
      Ala DVSNMAIIYK (88% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaHKECNGDP_4 - Region 2 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 302,758 - 440,601 nt. (total: 137,844 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 302757 - 440601:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (mal - Asn) + (D-Tyr - D-Asn - Ser - Glu) + (D-Ser - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 302757 - 380040:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal - Asn) + (D-Tyr - D-Asn - Ser - Glu) + (D-Ser - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 362931 - 440601:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg4_264: Ser - Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (267..674): Ser
  nrpys: Ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      ser (Ser)
    Single AA prediction:
      ser (Ser)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLIDK
    Nearest Stachelhaus code(s):
      Ser DVWHFSLIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1789..2188): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_265: Tyr - Asn - Ser - Glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (268..662): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DALSVGEVVK
    Nearest Stachelhaus code(s):
      Tyr DALSVGEVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1779..2174): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (3287..3694): Ser
  nrpys: Ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      ser (Ser)
    Single AA prediction:
      ser (Ser)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code(s):
      Ser DVWHFSLVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (4336..4743): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDLGVVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_266: pk - Asn
  Search NORINE for peptide: strict or relaxed
  CAL_domain (36..478): pk
  minowa: fatty_acid
  Prediction, score:
    fatty_acid: 624.6
    NH2: 18.6
    shikimic_acid: 0.0
    Acetyl-CoA: 0.0
    AHBA: 0.0
  AMP-binding (2956..3351): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_267: mal
  PKS_AT (6..290): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 62.5%
    inactive: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 75.7
    inactive: 30.0
    Methoxymalonyl-CoA: 20.4
    Propionyl-CoA: 11.8
    Methylmalonyl-CoA: 11.0
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg4_287: X
  AMP-binding (12..445): X
  nrpys: Asp, Asn, Glu, Gln, Aad
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      -GLHIAAPVK
    Nearest Stachelhaus code(s):
      Z-ahmohOrn FGLHIASTCK (56% 8Å match)
      Ile DGLFIGIPVK (32% 8Å match)
    Stachelhaus code match:
      60% (weak)
ctg4_291: Ile
  Search NORINE for peptide: strict or relaxed
  AMP-binding (473..866): Ile
  nrpys: Ile
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      ile (Ile)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFYGITFK
    Nearest Stachelhaus code(s):
      Ile DAFFYGITFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_292: Pro - Gln - Tyr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..866): Pro
  nrpys: Pro
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
    Small clusters prediction:
      pro (Pro)
    Single AA prediction:
      pro (Pro)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVQFIAHVVK
    Nearest Stachelhaus code(s):
      Pro DVQFIAHVVK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1500..1901): Gln
  nrpys: Gln
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGSVEK
    Nearest Stachelhaus code(s):
      Gln DAWHFGSVEK (100% 8Å match)
      Glu DAWHFGSVEK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2532..2924): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTITAEVAK
    Nearest Stachelhaus code(s):
      Tyr DGTITAEVAK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_293: Glu - X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (468..873): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1505..1898): X
  nrpys: Ala, Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVFWIGGTFK
    Nearest Stachelhaus code(s):
      Ala or Val DVFWIGGTFK (97% 8Å match)
      Val DVFWIGGTFK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_294: Tyr - Thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (474..867): Tyr
  nrpys: Tyr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Polar aromatic ring (Tyr, bOH-Tyr)
    Single AA prediction:
      tyr (Tyr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DGTLTAEVAK
    Nearest Stachelhaus code(s):
      Tyr DGTLTAEVAK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1509..1905): Thr
  nrpys: Thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
    Small clusters prediction:
      thr (Thr)
    Single AA prediction:
      thr (Thr)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code(s):
      Thr DFWNIGMVHK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg4_295: Glu - Orn
  Search NORINE for peptide: strict or relaxed
  AMP-binding (463..868): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      glu (Glu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWHFGGVDK
    Nearest Stachelhaus code(s):
      Glu DAWHFGGVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1500..1905): Orn
  nrpys: Orn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Long positively charged side chain (Orn, Lys, Arg)
    Small clusters prediction:
      Orn and hydroxy-Orn specific (Orn, OH-Orn)
    Single AA prediction:
      orn (Orn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVGEVGSIDK
    Nearest Stachelhaus code(s):
      Orn DVGEVGSIDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaHKECNGDP_4 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 463,580 - 485,463 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaHKECNGDP_5 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 112,189 - 135,371 nt. (total: 23,183 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg5_109

ctg5_106
Leader:
MSQEAIIRSWKDPFSRENSTQNPAGNPFSELKEAQMDKLVGA
Core:
G D M E A A C T F T L P G G G G V C T L T S E C I C
Core with dehydrations:
G D M E A A Cys Dhb F Dhb L P G G G G V Cys Dhb L Dhb Dha E Cys I Cys

#### MIBiG 3.1 matches for ctg5_106

30.0% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N N G G W C T L T K E C
25
28.6% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α
11
L P G G G G V C T L T S E C I
25
L G C T L T E C+
10
L G N K G A Y C T L T V E C M
24
12.8% BGC0001229 (SBI_06990): Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
18
C T L T S E C
24
C T L+ E C
28
C T L S K E C
34

#### antiSMASH-DB 4.0 matches for ctg5_106

100.0% NC_017912.1 and 14 others:
NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptide NZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptide NZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptide NZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptide NZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptide NZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptide NZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptide NZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptide NZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptide NZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptide NZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptide NZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptide NZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide
Lanthipeptides: MUS_RS20065_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T F T L P G G G G V C T L T S E C I C
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
96.2% NZ_BORO01000007.1: Lanthipeptides: KI343_RS07745_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T L T S E C I C
1
G D M E A A C T W T L P G G G G V C T L T S E C I C
26
92.3% NZ_JALASB010000016.1 and 3 others:
NZ_JALASR010000012.1 Lanthipeptides: MOD87_RS16305_lanthipeptide NZ_JALAUW010000005.1 Lanthipeptides: MOE83_RS03160_lanthipeptide NZ_JALAXQ010000010.1 Lanthipeptides: MOF24_RS12150_lanthipeptide
Lanthipeptides: MOD42_RS18070_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T+T S E C I C
1
G D M E A A C T W T L P G G G G V C T I T S E C I C
26
with 98 more sequence matches
92.3% NZ_KZ454939.1: Lanthipeptides: CEF20_RS01155_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T+T S E C I C
1
G D M E A A C T W T L P G G G G V C T V T S E C I C
26
40.0% NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide
Lanthipeptides: GTU71_RS12805_lanthipeptide
8
T F T L P G----G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S N V L G N Q G G W C T L T V E C
25
40.0% NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
8
T F T L P G----G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S N Y L G N N G G W C T L T K E C
25
40.0% NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
8
T F T L P----G G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S D Y L G N K G G W C T L T K E C
25
39.3% NZ_FOBE01000018.1: Lanthipeptides: BMW61_RS13085_lanthipeptide
2
D M E A A C T F T L P G G G G V C T L T S E C
24
+M A A L G C T L T E C
5
E M S A A----L G N R G S Y C T L T K E C
23
36.7% NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide
Lanthipeptides: BH683_RS28205_lanthipeptide
8
T F T L P----G G G G V C T L T S E
23
T F T L G G C T L T E
5
T F T L S D F L G N D G G W C T L T K E
24
35.3% NZ_SDLS01000001.1: Lanthipeptides: EIZ45_RS45960_lanthipeptide
2
D M E A A C T F T L P G G G G V C T L T S E C I C
26
D+ A T L P G +C T T E C C
10
D L A E A R T A A L P S S G Y I C T F T F E C N C
34
34.6% NZ_CP034669.1: Lanthipeptides: EJ065_RS32040_lanthipeptide
15
G G V C T L T S E C I C
26
G V C T L T+E C C
11
G Y V C T L T T E C G C
22
34.6% NZ_CP035495.1 and 1 other:
NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide
Lanthipeptides: ET495_RS17535_lanthipeptide
9
F T L P G G---G G V C T L T S E C
24
+T+P G G C T L+ E C
2
W T I P G T S T I G R F C T L S W E C
20
34.6% NZ_JALMDK010000017.1: Lanthipeptides: allorf_059288_059443_lanthipeptide
14
G G G V C T L T S E C I C
26
G G +C T L T E C C
3
G G Y I C T L T W E C N C
15
33.3% NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T L T E C+
5
T F S L S D Y W G N K G N W C T L T H E C M
26
33.3% NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T L T E C+
5
T F S L S D Y W G N R G Y W C T L T H E C M
26
33.3% NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G G C T T E C+
5
T F S L S D Y W G N K G G W C T A T H E C M
26
33.3% NZ_GG657757.1 and 1 other:
NZ_GG657757.1 Lanthipeptides: SSQG_RS20730_lanthipeptide
Lanthipeptides: SSQG_RS20730_lanthipeptide
8
T F T L P G----G G G V C T L T S E C
24
T F+L G G C T L T E C
8
T F S L S G I F G N D G D C C T L T K E C
28
33.3% NZ_JAJAGO010000028.1 and 1 other:
NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide
Lanthipeptides: LHJ74_RS33590_lanthipeptide
8
T F T L P G G G G----V C T L T S E C
24
T F+L G C T L T E C
5
T F S L S D A A G N D G W W C T L T K E C
25
32.3% NZ_PVMZ01000043.1 and 1 other:
NZ_PVMZ01000043.1 Lanthipeptides: CLV67_RS49720_lanthipeptide
Lanthipeptides: CLV67_RS49720_lanthipeptide
9
F T L P G G---G G V C T L T S E C
24
F T+P G G V C T + E C
2
F T V P G T S T I G Y V C T Y S Y E C
20
32.1% NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01725_lanthipeptide
Lanthipeptides: EL241_RS01725_lanthipeptide
10
T L P G G G G V C T L T S E C
24
+L G V C T L T E C
9
S L G N K G Y V C T L T K E C
23
31.0% NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G G C T++ E C+
5
T F S L S D Y W G N K G G W C T V S K E C M
26
31.0% NZ_LR027842.1: Lanthipeptides: E0E39_RS15855_lanthipeptide
9
F T L P G G---G G V C T L T S E C
24
+T+P G G V C T++ E C
2
W T V P G T R T I G A V C T V S W E C
20
31.0% NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide
Lanthipeptides: CN325_RS21835_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G V C T L T E C
11
L G N D G S V C T L T K E C
24
30.8% NC_015760.1 and 5 others:
NZ_CAJHJN010000010.1 Lanthipeptides: JMZ68_RS09030_lanthipeptide NZ_JACLQK010000036.1 Lanthipeptides: H7U04_RS11500_lanthipeptide NZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02800_lanthipeptide NZ_JAQCST010000021.1 Lanthipeptides: PGZ09_RS09470_lanthipeptide NZ_OU540596.1 Lanthipeptides: JQ838_RS05640_lanthipeptide
Lanthipeptides: SALIVB_RS03310_lanthipeptide
13
G G G G V C T L T S E C
24
G G V T L T E C
1
G N G V V L T L T H E C
12
30.8% NZ_CP036455.1 and 4 others:
NZ_JAGPXN010000019.1 Lanthipeptides: KBX06_RS22045_lanthipeptide NZ_JAODUN010000003.1 Lanthipeptides: BXY51_RS10560_lanthipeptide NZ_KB895893.1 Lanthipeptides: C569_RS0129325_lanthipeptide NZ_KB900614.1 Lanthipeptides: SALPAC6_RS0114155_lanthipeptide
Lanthipeptides: EKD16_RS25235_lanthipeptide
13
G G G G V C T L T S E C
24
G V C T L T E C
1
S S G W V C T L T I E C
12
30.8% NZ_JACHJG010000002.1: Lanthipeptides: FHS38_RS07010_lanthipeptide
8
T F T L P G G G G V C T L T S E C I C
26
+F P G V C + C I C
7
S F P T P I T G R V C N P D T G C I C
25
30.8% NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide
Lanthipeptides: EL241_RS01720_lanthipeptide
10
T L P G G G G V C T L T S E C
24
L G +C T L T E C
7
N L G N K G R I C T L T K E C
21
30.8% NZ_LT630004.1: Lanthipeptides: BQ5796_RS17475_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G C T L T E C+
6
L G N D G K F C T L T V E C M
20
30.0% NZ_AKXV01000031.1 and 8 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N Q G G W C T L T K E C
25
30.0% NZ_BJTV01000004.1 and 7 others:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N H G G W C T L T K E C
25
30.0% NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N T G G W C T L T V E C
25
30.0% NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N S G G W C T L T K E C
25
30.0% NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T L+ E C+
5
T F S L S D Y W G N N G N W C T L S H E C M
26
30.0% NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G G C T++ E C+
5
T F S L S D Y W G N K G G W C T I S H E C M
26
30.0% NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
10
T L P G G G G V C T L T S E C
24
+L G G C T L T E C
11
S L G N H G G W C T L T K E C
25
30.0% NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G +C T+T E C+
5
T F S L S D Y W G N N G W L C T I T H E C M
26
30.0% NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: HCC61_RS30395_lanthipeptide
Lanthipeptides: HCC61_RS30395_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L T N T G G W C T L T V E C
25
30.0% NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T T E C+
5
T F S L S D Y W G N N G N W C T A T H E C M
26
30.0% NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T L+ E C+
5
T F S L S D Y W G N R G N W C T L S H E C M
26
30.0% NZ_QLLX01000002.1 and 1 other:
NZ_QLLX01000002.1 Lanthipeptides: K378_RS05175_lanthipeptide
Lanthipeptides: K378_RS05175_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L T N Q G G W C T L T V E C
25
29.6% NZ_CP022163.1: Lanthipeptides: MEBOL_RS24465_lanthipeptide
11
L P G--G G G V C T L T S E C
24
+P G G G +C T ++E C
7
V P G N S G G W I C T Y S T E C
22
29.6% NZ_CP025249.1 and 1 other:
NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide
Lanthipeptides: CWT12_RS00385_lanthipeptide
15
G G V C T L T S E C
24
G V C T L T E C
13
G Y V C T L T K E C
22
29.6% NZ_CP071875.1: Lanthipeptides: J4I02_RS02880_lanthipeptide
14
G G G V C T L T S E C
24
G G +C T L T E C
8
G G A I C T L T H E C
18
29.6% NZ_CP114875.1: Lanthipeptides: O4Z47_RS14375_lanthipeptide
13
G G G G V C T L T S E C
24
G +C T L T S E C
7
S S G D I C T L T S E C
18
29.4% NC_014643.1 and 2 others:
NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS11600_lanthipeptide NZ_KV804818.1 Lanthipeptides: HMPREF2804_RS11135_lanthipeptide
Lanthipeptides: HMPREF0733_RS11155_lanthipeptide
4
E A A C T F T L P G G---G G V C T L T S E C
24
+A F T+P G G C T++ E C
4
Q A G G L F T V P G T T T V G H F C T I S W E C
27
29.0% NZ_GG657754.1 and 1 other:
NZ_GG657754.1 Lanthipeptides: SSOG_RS49055_lanthipeptide
Lanthipeptides: SSOG_RS49055_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C
24
G E +F + G C T T E C
3
G G A E Y V V S F V M G N L G N F C T A T L E C
26
28.6% NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G C T L T E C
10
L G N K G Q W C T L T K E C
23
28.6% NZ_CP006058.1 and 25 others:
NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide NZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide
Lanthipeptides: BAMY6639_RS13800_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G C T L T E C
10
L G N K G A W C T L T V E C
23
28.1% NZ_CP015591.1 and 19 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptide NZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide
Lanthipeptides: A7A70_RS27565_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G G C T L T E C+
14
L G N N G G Y C T L T K E C M
28
28.1% NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptide
Lanthipeptides: HGK68_RS15160_lanthipeptide
4
E A A C T F T L P G G---G G V C T L T S E C
24
A +T+P G G C T++ E C
1
R A G G I W T I P G T K T I G A F C T I S Y E C
24
27.6% NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G C T L T E C
10
L G N T G Q F C T L T K E C
23
27.6% NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G C T L T E C
10
L G N T G R F C T L T K E C
23
27.5% NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
5
A A C T F T L P G G G G V C T L T S E C
24
A A ++ L G V C T L T E C
16
A A A S Y I L G N P G H V C T L T V E C
35
26.9% NC_009480.1 and 10 others:
NZ_CP033724.1 Lanthipeptides: EFE39_RS10220_lanthipeptide NZ_CP047051.1 Lanthipeptides: GRD74_RS10365_lanthipeptide NZ_CP047054.1 Lanthipeptides: GRD61_RS10460_lanthipeptide NZ_CP053860.1 Lanthipeptides: DQP62_RS10825_lanthipeptide NZ_CP076352.1 Lanthipeptides: KN218_RS09900_lanthipeptide NZ_CP085137.1 Lanthipeptides: LHJ48_RS10290_lanthipeptide NZ_CP085140.1 Lanthipeptides: LHJ47_RS10305_lanthipeptide NZ_CP095274.1 Lanthipeptides: MU580_RS10460_lanthipeptide NZ_PSTW01000024.1 Lanthipeptides: C5C03_RS09675_lanthipeptide NZ_SISU01000002.1 Lanthipeptides: EOG37_RS09890_lanthipeptide
Lanthipeptides: CMM_RS10575_lanthipeptide
12
P G G G G V C T L T S E C
24
G +C T L T E C
1
S S S G W L C T L T I E C
13
26.9% NZ_BMEX01000022.1: Lanthipeptides: IEV46_RS16225_lanthipeptide
13
G G G G V C T L T S E C
24
G G V C T T +C
2
G C G N V C T W T K D C
13
26.9% NZ_BMMB01000007.1 and 1 other:
NZ_BMMB01000007.1 Lanthipeptides: IEX62_RS15675_lanthipeptide
Lanthipeptides: IEX62_RS15680_lanthipeptide
12
P G G G G V C T L T S E C
24
P G G + T L T +C
3
P G D G W I T T L T D D C
15
26.9% NZ_CP050134.2 and 3 others:
NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide
Lanthipeptides: HBA49_RS00770_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G C T+T E C+
5
L G N N G R W C T I T K E C M
19
26.9% NZ_CP061274.1 and 1 other:
NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide
Lanthipeptides: H9X71_RS09850_lanthipeptide
12
P G G G G V C T L T S E C
24
G +C T L T E C
1
A S S G W L C T L T I E C
13
26.9% NZ_LWKZ01000001.1: Lanthipeptides: A6A06_RS41385_lanthipeptide
13
G G G G V C T L T S E C I C
26
G C T+T+E C C
2
S S G Y F C T I T T E C F C
15
26.7% NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide
Lanthipeptides: IE314_RS15865_lanthipeptide
15
G G V C T L T S E C
24
G G C T L T E C
16
G G W C T L T K E C
25
26.7% NZ_CYXV01000003.1: Lanthipeptides: ARB75_RS04585_lanthipeptide
14
G G G V C T L T S E C
24
G G C T L T E C
8
G G I A C T L T G E C
18
26.7% NZ_FNHR01000005.1 and 1 other:
NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide
Lanthipeptides: BLQ37_RS05590_lanthipeptide
8
T F T L P----G G G G V C T L T S E C I
25
T F+L G C T++ E C+
5
T F S L S D Y M G N N G N W C T I S H E C M
26
26.7% NZ_RKNR01000012.1 and 1 other:
NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide
Lanthipeptides: EGW35_RS11615_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G G C T T E C+
12
L G N T G G W C T A T K E C M
26
26.5% NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
3
M E A A C T F T L P G G G G V C T L T S E C
24
+ T L G V C T T E C
8
F S S V V T L A L G N N G Y V C T W T H E C
29
25.8% NZ_QGGR01000002.1: Lanthipeptides: BC793_RS05490_lanthipeptide
9
F T L P G G---G G V C T L T S E C
24
+T+P G G +C T++ E C
2
Y T V P G T S T I G W I C T V S W E C
20
25.7% NC_015957.1: Lanthipeptides: STRVI_RS53125_lanthipeptide
15
G G V C T L T S E C I C
26
G V C T L T+E C C
24
G W V C T L T T E C G C
35
25.0% NC_002570.2 and 3 others:
NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide NZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide
Lanthipeptides: AYT26_RS02480_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G C T L T E C+
14
L G N K G A Y C T L T V E C M
28
25.0% NC_018499.1 and 20 others:
NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptide NZ_JANIOB010000033.1 Lanthipeptides: NQ113_RS28005_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptide NZ_JH791925.1 Lanthipeptides: IE3_RS28545_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide NZ_NUML01000015.1 Lanthipeptides: COD66_RS20150_lanthipeptide NZ_NUML01000015.1 Lanthipeptides: COD66_RS20145_lanthipeptide NZ_NUVR01000040.1 Lanthipeptides: COI88_RS26655_lanthipeptide NZ_NUVR01000040.1 Lanthipeptides: COI88_RS26650_lanthipeptide
Lanthipeptides: BCK_RS27860_lanthipeptide
15
G G V C T L T S E C I
25
G G C T L T E C+
18
G G Y C T L T K E C M
28
25.0% NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
8
T F T L P G G G G V C T L T S E C I
25
+ T L G V C T T E C+
15
S M T L G N N G W V C T A T K E C M
32
25.0% NZ_JAQDBP010000004.1 and 18 others:
NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptide NZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptide NZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptide NZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptide NZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptide NZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptide NZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptide NZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide
Lanthipeptides: PGY07_RS07085_lanthipeptide
2
D M E A A C T F T L P G G G G V C T L T S E C
24
D+ + +L G V C T++ E C
1
D L T S N K V D S L A S S G V V C T I S V E C
23
25.0% NZ_KE384107.1: Lanthipeptides: G586_RS23925_lanthipeptide
10
T L P G G G G V C T L T S E C
24
+L G C T+T E C
9
S L G N R G S Y C T I T K E C
23
24.1% NZ_KV795763.1 and 2 others:
NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide
Lanthipeptides: allorf_248182_248337_lanthipeptide
15
G G V C T L T S E C I
25
G V C T+T E C+
15
G R V C T V T V E C M
25
23.8% NZ_BMFU01000012.1 and 7 others:
NZ_BMFU01000012.1 Lanthipeptides: IEW26_RS25375_lanthipeptide NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_JAHXMW010000012.1 Lanthipeptides: KZX51_RS23855_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: FS579_RS24445_lanthipeptide
Lanthipeptides: IEW26_RS25375_lanthipeptide
5
A A C T F T L P G G G G V C T L T S E C
24
A A ++ + G V C T L T E C
18
A A A S Y F M G N P G H V C T L T V E C
37
23.7% NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
8
T F T L P G G G G V C T L T S E C I
25
++ L G V C T T E C I
16
S Y A L G D K G Q V C T A T V E C I
33
23.5% NZ_BQXZ01000001.1 and 1 other:
NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide
Lanthipeptides: OCU69_RS05000_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C
24
G + + + G V C T T E C
5
G T I S I T L S V Y M G N K G S V C T W T I E C
28
23.5% NZ_CP040417.1 and 9 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
15
G G V C T L T S E C
24
G V C T L T E C
15
G K V C T L T W E C
24
23.3% NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS0118200_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS0118200_lanthipeptide
Lanthipeptides: K329_RS0118200_lanthipeptide
15
G G V C T L T S E C I
25
G G C T L+ E C+
16
G G W C T L S Q E C M
26
23.1% NZ_CP086242.1 and 1 other:
NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide
Lanthipeptides: LL038_RS25355_lanthipeptide
12
P G G G G V C T L T S E C
24
G +C T T+E C
1
A S S G A I C T A T T E C
13
23.1% NZ_MJEH01000022.1: Lanthipeptides: BFG57_RS09480_lanthipeptide
12
P G G G G V C T L T S E C
24
P G G + T+T +C
4
P G D G W I S T I T D D C
16
22.9% NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS23445_lanthipeptide
Lanthipeptides: EMA17_RS23445_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G C T L T E C
17
L G N H G N W C T L T K E C
30
22.2% NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C
24
G + + + G V C T T E C
5
G T I S I T L S V Y M G N D G K V C T W T V E C
28
21.9% NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
13
G G G G V C T L T S E C
24
G C T L T E C
11
N D G K Y C T L T W E C
22
21.6% NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide
11
L P G G G G V C T L T S E C
24
L G V C T T+E C
19
L G N D G W V C T W T A E C
32
21.6% NZ_BCEY01000006.1 and 1 other:
NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide
Lanthipeptides: GOZ53_RS01290_lanthipeptide
8
T F T L P G G G G V C T L T S E C
24
+F L G +C T T+E C
16
S F A L G N D G W I C T W T A E C
32
21.2% NC_018089.1 and 13 others:
NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptide NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide NZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptide NZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptide NZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptide NZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptide NZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide NZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide
Lanthipeptides: SMUGS5_RS08725_lanthipeptide
3
M E A A C T F T L P G G G G V C T L T S E C I
25
+ + + L G +C T+T E C+
6
V N S T F S I V L G N K G Y I C T V T V E C M
28
21.1% NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
10
T L P G G G G V C T L T S E C I
25
T G V C T T E C+
18
T F G N K G K V C T Y T V E C V
33
20.6% NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
8
T F T L P G G G G V C T L T S E C
24
++ L G +C T+T E C
12
S W A L G N N G H L C T V T V E C
28
20.6% NZ_CP042598.1 and 2 others:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide
Lanthipeptides: FUT28_RS13825_lanthipeptide
15
G G V C T L T S E C I
25
G G C T T E C+
20
G G W C T A T K E C M
30
19.4% NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
11
L P G G G G V C T L T S E C I
25
L G V C T + E C+
18
L G N D G W V C T W S K E C M
32
19.4% NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
13
G G G G V C T L T S E C I
25
G V C T T E C+
20
N D G K V C T Y T V E C V
32
19.4% NZ_CP034248.1: Lanthipeptides: EIM92_RS14995_lanthipeptide
13
G G G G V C T L T S E C
24
G G +C T++ E C
6
S G G V I C T I S H E C
17
19.2% NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: allorf_0090688_0090780_lanthipeptide
Lanthipeptides: allorf_0090688_0090780_lanthipeptide
2
D M E A A C T F T L P
12
E A A C+++ P
1
S R E A A C S W S Q P
11
18.9% NZ_CP115450.1 and 1 other:
NZ_CP115450.1 Lanthipeptides: O1G21_RS35415_lanthipeptide
Lanthipeptides: O1G21_RS35415_lanthipeptide
6
A C T F T L P G G G G V C T L T S E C
24
A ++ + G +C T+T+E C
13
A A S W A M G N N G Y L C T V T A E C
31
18.8% NC_006322.1 and 7 others:
NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide NZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide
Lanthipeptides: BLI_RS20295_lanthipeptide
13
G G G G V C T L T S E C I
25
G +C T+T E C+
16
N N G Y L C T V T K E C M
28
18.4% NZ_BMRY01000003.1 and 28 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
8
T F T L P G G G G V C T L T S E C
24
++ L G C T T+E C
17
S Y V L G N N G N F C T A T A E C
33
17.9% NZ_LUCO01000016.1: Lanthipeptides: BMBG_RS27155_lanthipeptide
15
G G V C T L T S E C
24
G V C T L++E C
20
G R V C T L S A E C
29
17.6% NZ_LMFO01000023.1: Lanthipeptides: allorf_629531_629758_lanthipeptide
15
G G V C T L T S E C
24
G C T T+E C
18
G N F C T F T T E C
27
16.7% NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24800_lanthipeptide
Lanthipeptides: LL065_RS24800_lanthipeptide
8
T F T L P G G G G V C T L T S E C
24
++ L G +C T + E C
16
S Y A L G N Q G K I C T W S V E C
32
16.7% NZ_FNVT01000006.1: Lanthipeptides: C4V41_RS24485_lanthipeptide
3
M E A A C T F T L P G G G G V C
18
+E+ T T P G G G C
20
V E S E I T M T G P G G S G R C
35
16.2% NZ_JAQFWW010000005.1: Lanthipeptides: PDT38_RS15180_lanthipeptide
15
G G V C T L T S E C I
25
G C T L++E C
21
G K Y C T L S A E C F
31
12.5% NZ_CP011152.1 and 5 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28820_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28815_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28820_lanthipeptide
10
T L P G G G G V C T L T S E C
24
T L G C T+T E C
45
T L G N K G H A C T I T K E C
59

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg5_106 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 2399.0 Da
  Molecular weight: 2400.8 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2418.8 Da N = 1

gnlProkkaHKECNGDP_6 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 58,235 nt. (total: 58,235 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 58235:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val - Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg6_16: Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (469..867): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFFLGCVFK
    Nearest Stachelhaus code(s):
      Leu DAFFLGCVFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg6_17: Val - Asp - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (470..864): Val
  nrpys: Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWIGGTFK
    Nearest Stachelhaus code(s):
      Val DAFWIGGTFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1502..1904): Asp
  nrpys: Asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asp (Asp)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKVGHIGK
    Nearest Stachelhaus code(s):
      Asp DLTKVGHIGK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2547..2936): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (97% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg6_18: Glu - Leu - Leu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..867): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      gln (Gln)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDLGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDLGVVDK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1511..1908): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFMMGMVFK
    Nearest Stachelhaus code(s):
      Leu DAFMMGMVFK (100% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2550..2939): Leu
  nrpys: Leu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      leu (Leu)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWFLGNVVK
    Nearest Stachelhaus code(s):
      Leu DAWFLGNVVK (97% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaHKECNGDP_6 - Region 2 - NRPS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 136,691 - 214,421 nt. (total: 77,731 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 136690 - 214421:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - D-Phe) + (Asp - D-Asn - Gly) + (ccmal) + (ccmal) + (mal - D-Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg6_133: Glu
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1198..1599): Glu
  nrpys: Glu
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      glu,gln (Glu, Gln)
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAKDIGVVDK
    Nearest Stachelhaus code(s):
      Glu DAKDIGVVDK (85% 8Å match)
    Stachelhaus code match:
      100% (strong)
ctg6_137: mal
  PKS_AT (6..293): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 83.3%
    inactive: 75.0%
    2-Methylbutyryl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 111.1
    inactive: 50.8
    Methoxymalonyl-CoA: 39.3
    Isobutyryl-CoA: 31.6
    Methylmalonyl-CoA: 29.7
    Propionyl-CoA: 12.0
    CHC-CoA: 10.8
    fatty_acid: 10.4
    Benzoyl-CoA: 10.0
    trans-1,2-CPDA: 0.0
    Ethylmalonyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg6_138: Asp - Asn - Gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (264..665): Asp
  nrpys: Asp
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asp (Asp)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGHVGK
    Nearest Stachelhaus code(s):
      Asp DLTKIGHVGK (65% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1303..1697): Asn
  nrpys: Asn
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
    Large clusters prediction:
      Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
    Small clusters prediction:
      asp,asn (Asp, Asn)
    Single AA prediction:
      asn (Asn)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLTKIGEVGK
    Nearest Stachelhaus code(s):
      Asn DLTKIGEVGK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (2805..3198): Gly
  nrpys: Gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
    Single AA prediction:
      gly (Gly)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQMGMIWK
    Nearest Stachelhaus code(s):
      Gly DILQMGMVWK (85% 8Å match)
    Stachelhaus code match:
      90% (moderate)
ctg6_139: Val - Phe
  Search NORINE for peptide: strict or relaxed
  AMP-binding (248..645): Val
  nrpys: Val
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
    Small clusters prediction:
      Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
    Single AA prediction:
      val (Val)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAFWLGGTFK
    Nearest Stachelhaus code(s):
      Val DAFWLGGTFK (94% 8Å match)
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1287..1678): Phe
  nrpys: Phe
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
    Large clusters prediction:
      Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
    Small clusters prediction:
      Unpolar aromatic ring (Phe, Trp)
    Single AA prediction:
      phe (Phe)
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DAWTIAAICK
    Nearest Stachelhaus code(s):
      Phe DAWTIAAICK (91% 8Å match)
    Stachelhaus code match:
      100% (strong)

gnlProkkaHKECNGDP_7 - Region 1 - transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 46,470 nt. (total: 46,470 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 46470:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  ctg7_1 + ctg7_2 + ctg7_3 + ctg7_4

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
gnlProkkaHKECNGDP_7 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 162,411 - 203,511 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaHKECNGDP_9 - Region 1 - LAP,RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 26,754 - 49,931 nt. (total: 23,178 nt) Show pHMM detection rules used
LAP: ((((goadsporin_like or PF00881 or TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or TIGR03602) and not cyanobactin_synth)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
gnlProkkaHKECNGDP_14 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 34,055 nt. (total: 34,055 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 34055:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg14_3: X
  AMP-binding (15..363): X
  nrpys: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      IGNPTGTIFK
    Nearest Stachelhaus code(s):
      2,3-dohHda IGNPTGTIMK (74% 8Å match)
    Stachelhaus code match:
      90% (moderate)
ctg14_6: mal
  PKS_AT (4..281): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 79.2%
    inactive: 62.5%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 86.6
    Methoxymalonyl-CoA: 24.9
    inactive: 23.4
    2-Methylbutyryl-CoA: 14.3
    Methylmalonyl-CoA: 14.1
    Propionyl-CoA: 13.1
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0

gnlProkkaHKECNGDP_15 - Region 1 - transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 23,013 nt. (total: 23,013 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 23013:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (ohmal - mal) + (mal) + (ccmal)
Non-colinear ordering:
  ctg15_2 + ctg15_3 + ctg15_4 + ctg15_5

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form