LOCUS       c00041_gnlPro..        13936 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NADAGIKK_46.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 12:53:42
            Original ID  :: gnl|Prokka|NADAGIKK_46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13936
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13936
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[644:3936]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      645..3936
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13936
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13936
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             645..2369
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-54, bitscore:
                     177.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAVL
                     PIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADAMI
                     DSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFHIAT
                     TGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAKKPVI
                     LAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYTANMAL
                     HECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGDSKIVLQ
                     ELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTKGEAIVAT
                     DVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVAVVGDGGFQ
                     MTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQPDFVKLSEAY
                     GIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGLHEMVGVKP"
     CDS             2366..2884
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_2"
                     /sec_met_domain="ALS_ss_C (E-value: 3.5e-31, bitscore:
                     101.0, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVSR
                     ITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEING
                     IIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQQKA
                     SSNKTISIV"
     CDS             2908..3936
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_3"
                     /sec_met_domain="IlvN (E-value: 1.7e-77, bitscore: 252.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.2e-68, bitscore: 221.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVIV
                     GVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKSLV
                     FAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEARDK
                     ALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGYQPEL
                     AYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKEVLKDI
                     QNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKEAVVSVA
                     QN"
     CDS             3923..5479
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg41_4"
                     /sec_met_domain="HMGL-like (E-value: 1.8e-99, bitscore:
                     326.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEAG
                     FPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKEGAHPRIHVFIATSDI
                     HLKHKLKMTREQVIERAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGAS
                     VINLPDTVGYLAPAEYGNIFRYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIENGAD
                     QIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLTGMAVP
                     RNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRL
                     TALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEFLSLQVHY
                     GTSQVPTATLSLKNQENAELIQEAATGAGSVEAIYNTLERCIDKDVELLDYRIQSNRKG
                     EDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMSGLKNHTAVG
                     S"
     CDS             5500..6597
                     /locus_tag="ctg41_5"
                     /transl_table=11
                     /translation="LKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIGG
                     AAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLFAN
                     LRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVDTLF
                     YKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKLEHML
                     VDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVH
                     GSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTRDLARSE
                     EFSSTQAITEEVKAAIMSENTISNV"
     CDS             6647..8065
                     /locus_tag="ctg41_6"
                     /transl_table=11
                     /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEGL
                     RQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHSVD
                     QGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRP
                     KTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMTVCNM
                     SIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFAKAVEEWKALRTDPGAVYDKSIVLDG
                     NKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKIEDIKVE
                     HVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLDQIFLEAG
                     FEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGH
                     FVDVRKFYQEKTVV"
     CDS             8078..8677
                     /locus_tag="ctg41_7"
                     /transl_table=11
                     /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFFD
                     WRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPSFA
                     DIFHQNCFKNGMLPIRMPYDNWKQLVGQYENKSLEMTVDLEKQLIHDSEGNQISFEVDP
                     HWKEMLINGYDEISLTLLLEDDIKQFESQRSSWLQA"
     CDS             8796..9800
                     /locus_tag="ctg41_8"
                     /transl_table=11
                     /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAMK
                     YDDTESDLHLGMAICFLELGELEEAKSVCEKMLKEGYGHYFTVLQVYMTILIQLKKYEE
                     VKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVLASP
                     EEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHISKFGE
                     SLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPFQPKLL
                     SADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL"
     CDS             10028..11302
                     /locus_tag="ctg41_9"
                     /transl_table=11
                     /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGFR
                     KGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGESL
                     IFTAKVTVKPEVKLGDYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAVEEG
                     NTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVTFPEE
                     YHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRLEEAKE
                     NEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELYTQFSGQ
                     DEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNMPVENIKQ
                     AIGSTDAMKEDLKVRKAIDFLVENR"
     CDS             11574..12836
                     /locus_tag="ctg41_10"
                     /transl_table=11
                     /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTEI
                     VEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKVDD
                     VELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLI
                     QAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQ
                     GGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLEKEDLL
                     SKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKMLELDNV
                     ELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVITGATVTH
                     GEPPRLLLKDGTEVSQDKTSA"
ORIGIN
        1 actcttgata gattaataaa aaaattataa aaacttttaa catttgcaat tccttttgta
       61 ccaataatga aagcgtatac aatatagttt gattaatcga aattgtctaa taattttaaa
      121 aaatgctgtt gacactgcgt ccaaagcggc gtaatatgag ttcaacaaaa gataaacgca
      181 agcttcacaa gcgaaaatca tcgcagtatg attctaaaaa aatgaaaaac aaacgacctt
      241 cttgaacagc tggaaagccg ttccgaaggc tgaatatgaa aagcgcagat gaggataagt
      301 agccttgaaa aagctttcca cagagaaccg ggttagctga gaaccggcga agctttacaa
      361 ggtgaactcg cctcagagtg ccagtctgaa atgacagtag gacttggccg ggtgaacttg
      421 attcactcgt tactaaagcg gatagaaata tccatgagac ggccgattaa caggccgtaa
      481 acaagggtgg taccgcggaa agaaaagcct tttcgcccct tttagctatc gcagttactg
      541 cgcggctgat tgtgggcgga agggcttttt ttattgaata atcagctata tagataatga
      601 aaagatgatc tttaaaggat gaaaatccaa aaggaggaac taaaatgggg actaatgtac
      661 aggtggattc agcatctgcc gaatgtacac agacgatgag cggagcatta atgctgattg
      721 aatcattaaa aaaagagaaa gtagaaatga tcttcggtta tccgggcggg gctgtgcttc
      781 cgatttacga taagctatac aattcagggt tggtacatat ccttccccgt cacgaacaag
      841 gagcaattca tgcagcggag ggatacgcaa gggtctccgg aaaaccgggt gtcgtcattg
      901 ccacgtcagg gccgggagcg acaaaccttg ttacaggcct tgctgatgcc atgattgatt
      961 cattgccgtt agtcgtcttt acagggcagg tagcaacctc tgtaatcggg agcgatgcat
     1021 ttcaggaagc agacatttta gggattacga tgccagtaac aaaacacagc taccaggttc
     1081 gccagccgga agatctgccg cgcatcatta aagaagcgtt ccatattgca acaactggaa
     1141 gacccggacc tgtattgatt gatattccga aagatgtagc aacaattgaa ggagaattca
     1201 gctacgatca tgagatgaat ctcccgggat accagccgac aacagagccg aattatttgc
     1261 agatccgcaa gcttgtggaa gccgtgagca gtgcgaaaaa accggtgatc ctggcgggtg
     1321 cgggcgtact gcacggaaaa gcgtcagaag aattaaaaaa ttatgccgaa cagcagcaaa
     1381 tccctgtggc acacaccctt ttggggctcg gaggcttccc ggctgaccat ccgctttttc
     1441 tagggatggc gggaatgcac ggtacttata cagccaatat ggcccttcat gaatgtgatc
     1501 tattaatcag tatcggcgcc cgttttgatg accgtgtcac aggaaacctg aaacactttg
     1561 ccagaaacgc aaagatagcc cacatcgata ttgatccagc tgaaatcgga aaaatcatga
     1621 aaacacagat tcctgtagtc ggagacagca aaattgtcct gcaggagctg atcaaacaag
     1681 acggcaaaca aagcgattca agcgaatgga aaaaacagct cgctgaatgg aaagaagagt
     1741 atccgctctg gtatgtagat aatgaagaag aaggttttaa acctcagaaa ttgattgaat
     1801 atattcatca atttacaaaa ggagaggcca ttgtcgcaac ggatgtaggc cagcatcaaa
     1861 tgtggtcagc gcaattttat ccgttccaaa aagcagataa atgggtcacg tcaggcggac
     1921 ttggaacgat gggattcggt cttccggcgg cgatcggcgc acagctggcc gaaaaagatg
     1981 ctactgttgt cgcggttgtc ggagacggcg gattccaaat gacgcttcaa gaactcgatg
     2041 ttattcgcga attaaatctt ccggtcaagg tagtgatttt aaataacgct tgtcttggaa
     2101 tggtcagaca gtggcaggaa attttctatg aagaacgtta ttcggaatcc aaattcgctt
     2161 ctcagcctga cttcgtcaaa ttgtccgaag catacggcat taaaggcatc agaatttcat
     2221 cagaagcgga agcaaaggaa aagctggaag aggcattgac atcaagagaa cctgttgtca
     2281 ttgacgtgcg ggttgccagc gaagaaaaag tattcccgat ggtggctccg gggaaagggc
     2341 tgcatgaaat ggtgggggtg aaaccttgaa aagaattatc acattgactg tggtgaaccg
     2401 ctccggagtg ttaaaccgga tcaccggtct attcacaaaa aggcattaca acattgaaag
     2461 cattacagtt ggacacacag aaacagccgg cgtttccaga atcaccttcg tcgttcacgt
     2521 tgaaggagaa aatgatgttg aacagttaac gaaacagctc aacaaacaga ttgatgtgct
     2581 gaaagtcaca gacatcacaa atcaatcgat tgtccagagg gagctggcct taatcaaggt
     2641 tgtctccgca ccttcaacga gaacagagat taatggaatc atagaaccgt ttagagcctc
     2701 tgtcgttgat gtcagcagag acagcatcgt tgttcaggtg acgggtgaat ctaacaaaat
     2761 tgaagcgctt attgagttat taaaacctta tgggattaaa gaaatcgcga gaacaggtac
     2821 aacggctttt gcgaggggaa cccagcaaaa ggcgtcatcc aataaaacaa tatctattgt
     2881 ataaaacata acaagggaga gattaaaatg gtaaaagtat attataacgg tgatatcaaa
     2941 gagaacgtat tggctggaaa aacagtagcg gttatcgggt acggttcgca aggccacgca
     3001 catgccctga accttaaaga aagcggagta gacgtgatcg tcggtgttag acaaggaaaa
     3061 tctttcactc aagcccaaga agacggacat aaagtatttt cagtaaaaga agcggcagcc
     3121 caagccgaaa tcatcatggt tctgcttccg gatgagcagc agcaaaaagt atacgaagct
     3181 gaaatcaaag atgaattgac agcaggaaaa tcattagtat tcgctcatgg atttaacgtg
     3241 catttccatc aaattgttcc tccggcggat gtagatgtat tcttagtggc ccctaaaggc
     3301 ccgggacact tggtaagaag aacatatgag caaggagctg gcgtacctgc attgttcgca
     3361 atctatcaag atgtgactgg agaagcaaga gacaaagccc tcgcttatgc taaaggaatc
     3421 ggcggcgcaa gagctggcgt attagaaacg acatttaaag aagaaacaga aacagatttg
     3481 ttcggtgagc aagcagttct ttgcggcgga ttaagcgcgc ttgtcaaagc cggatttgaa
     3541 acattaactg aagcaggtta tcagcctgaa cttgcatact tcgagtgcct tcatgagctg
     3601 aaattaatcg tagaccttat gtacgaagaa ggacttgcag gaatgagata ttcaatctct
     3661 gacaccgcac agtggggaga tttcgtatca ggtcctcgcg ttgtggacgc taaagtaaaa
     3721 gaatctatga aagaagtatt aaaagatatc caaaacggta cattcgcaaa agagtggatc
     3781 gtcgaaaacc aagtaaaccg tcctcgtttc aacgctatca atgcaagcga gaacgaacat
     3841 caaatcgaag tagtgggaag aaagcttcgt gaaatgatgc cgtttgtgaa acaaggcaag
     3901 aagaaggaag cggtggtctc cgttgcgcaa aattaatttt ttcgatacga cgcttcgtga
     3961 tggtgaacag tcccctggag tgaacttgaa tacacaggag aaacttgcca tagctaagca
     4021 gctcgaaaga ctcggggcag atatcattga agcgggattt cccgcttcgt cccgaggtga
     4081 ctttttagct gttcaggaaa tcgcaagaac cattaaaaat tgttcagtaa ctggtctggc
     4141 ccgttgtgta aaaggtgata ttgatgctgc ttgggaagcg ttaaaagaag gtgctcatcc
     4201 gagaatacat gtttttatcg ctacatcgga cattcatttg aagcacaagc tgaaaatgac
     4261 acgtgagcaa gtcattgaaa gagcggttga aatggtgaaa tacgcaaaag aacgttttcc
     4321 gattgtgcaa tggtcagctg aagatgcctg ccgcactgaa ctgccgtttc tagcagaaat
     4381 cgtcgaaaaa gtgattgacg caggcgccag tgttatcaat cttccggaca ctgtcggcta
     4441 cctggctccg gcggaatacg gaaatatctt tagatatatg aaggaaaacg ttccgaacat
     4501 tcacaaagca aagctttcag cccactgtca tgatgatttg ggaatggcag tcgcaaactc
     4561 tcttgctgcg attgaaaatg gcgctgatca aatcgaatgt gctgtgaacg ggatcggtga
     4621 aagagccgga aacgcggcat tagaggaaat tgccgtagcc ctccatacca gaaaagattt
     4681 ctaccaagtc gaaacaggca ttacactgaa cgagattaag agaacaagtg atttagtaag
     4741 caaactgaca ggcatggctg tcccgcgcaa caaagcggtt gttggagata atgcatttgc
     4801 tcatgaatca ggcatccatc aggacggctt tttaaaggaa aaatcgactt atgaaattat
     4861 ttcaccggag cttgtcggcg taaccgcaga tgcgcttgtc ctaggtaaac attccggacg
     4921 ccacgcattt aaagaccggc tgactgcttt aggattccaa tttgacagtg aagagattaa
     4981 taaattcttt acgatgttca aagagttgac tgagaagaaa aaagaaatca ctgatgagga
     5041 tcttgtttct cttattttag aagaaaaagt aacagatcgc aagattgggt atgaatttct
     5101 ttctcttcaa gtacattacg gaacaagtca ggtccctacg gctactcttt cgttgaaaaa
     5161 tcaagaaaac gcagagctta ttcaggaagc tgcaactgga gctggaagcg tggaagcaat
     5221 ctacaatacg cttgagcgct gcatcgataa ggacgtagag ctcttagact accgcattca
     5281 gtctaacaga aaaggcgaag atgcatttgc ccaggtgtat gtaagagttt tggtgaacgg
     5341 aaaagaatca gcagggcggg gcatagcgca agacgtatta gaagcatcag cgaaagctta
     5401 tttgaacgca gtcaaccgtc aattggtttt ccagtcgaat atgagcggat tgaaaaacca
     5461 cacagctgtc ggatcataaa agaaaggaga acggttaact tgaagaaacg tattgctcta
     5521 ttgcccggag acgggatcgg ccctgaagta ttagaatcag cgacagacgt actgaaaagt
     5581 gttgccgaac gctttaacca tgaatttgaa tttgaatatg gcctgattgg aggggcggct
     5641 attgatgaac atcataaccc cctcccggag gaaaccgttg ctgcttgtaa aaatgcagac
     5701 gcgatattgc ttggtgctgt cggcggaccg aaatgggatc aaaatccttc ggaactgaga
     5761 ccggaaaaag ggctgctcag catcagaaaa cagcttgatt tgtttgcgaa tttacggcct
     5821 gtgaaggtat ttgaaagcct ttctgacgct tcgcctttga aaaaagaata tatagataat
     5881 gttgatttcg ttatcgttcg tgagctcaca ggcggcttgt atttcggcca gccgagcaaa
     5941 cgctatgtaa acactgaagg tgagcaggaa gcagtagata cactgtttta taagcgaacg
     6001 gaaattgaac gagtgatcag agagggcttc aaaatggcgg cagccagaaa aggcaaagtg
     6061 acctctgtag ataaagcgaa tgttcttgaa tcaagccggc tgtggcgtga agtggctgag
     6121 gacgttgcac aagagtttcc tgatgtgaag cttgagcaca tgcttgtgga taacgcggcc
     6181 atgcagctaa tttatgcacc gaatcaattt gatgtcgtgg tgactgaaaa tatgttcggt
     6241 gatattttaa gcgatgaagc gtccatgctt acaggctcgc tcggaatgct cccgtcagcc
     6301 agcctatcaa gctctggcct tcatctgttt gaacctgttc atggctccgc gcctgatatt
     6361 gctggtaaag ggatggcaaa tccgttcgca gccatattgt cagcggcaat gcttttgaga
     6421 acatctttcg ggcttgaaga ggaagcgaaa gctgtagaag atgcggtaaa caaagtcttg
     6481 gcttctggaa aaagaacaag agacttggca cggagtgaag agttcagcag cactcaggcc
     6541 attacagagg aagttaaggc agcaatcatg agtgaaaata caatttctaa tgtgtgacag
     6601 cttacgttaa gcagtcttag ctctaggtag agggaggaaa taaaagatga tgcctcgaac
     6661 aatcatcgaa aagatttggg atcagcatat tgtaaaacat ggtgagggaa agccggatct
     6721 tctctatatt gatttgcacc tcattcatga ggtgacgtct cctcaggcat ttgaaggctt
     6781 gagacaaaag ggaagaaagg tcagaagacc ccaaaacaca tttgcgacaa tggaccacaa
     6841 catcccgact gtcaatcgtt ttgagataaa ggatgaagtt gcgaaacgcc aggtaacggc
     6901 gcttgaaaga aactgtgagg aatttggcgt gcgccttgcc gatcttcaca gtgtggatca
     6961 agggattgtc catgtcgtcg gacctgaact aggcttaacg cttccaggga aaacgattgt
     7021 gtgcggtgac agtcatacat caacacatgg cgctttcggc gctcttgcat ttggaatcgg
     7081 gacgagtgaa gttgaacatg tcctttccac acagacactt tggcagcagc gtccaaaaac
     7141 actggaagtg cgcgtagatg gaacgcttca aaaaggggta acggcaaagg atgtcatcct
     7201 tgctgtcatc ggcaaatacg gtgtgaaatt cggcacaggc tacgtcattg aatacactgg
     7261 ggaagtattc agaaatatga cgatggatga acgaatgact gtttgtaaca tgtcaattga
     7321 agcaggagca agagcaggtt tgattgcacc tgatgaggtg acgtttgaat attgcaaaaa
     7381 tcgcaagtac acgccaaaag gcgaagaatt tgccaaggcc gtagaggaat ggaaggcgct
     7441 gcgcacagac ccgggcgctg tttatgataa atctatcgtc cttgacggca acaaaatttc
     7501 ccctatggtg acatggggca ttaacccggg aatggttctt cctgtcgatt ctgaagttcc
     7561 tgcgccggaa agcttttctg cagaagatga taaaaaagaa gcgattcgcg cttatgaata
     7621 tatgggactg actcctcatc agaaaattga agacattaaa gtggagcacg tatttatcgg
     7681 ttcctgcacg aattcccgca tgactgacct tcgccaggct gctgacatga tcaaggggaa
     7741 gaaggtagct gacagcgtaa gggccatcgt cgtgcccgga tcccaaagcg tgaagcttca
     7801 ggctgaaaaa gaagggcttg accagatttt cttggaagct ggatttgaat ggagagagtc
     7861 aggctgcagc atgtgtttga gtatgaataa tgatgttgtt cctgagggag agcgctgtgc
     7921 atcaacctct aaccgcaact tcgagggcag acaaggaaaa ggtgcaagaa cacatctcgt
     7981 cagcccggca atggctgcga tggctgccat tcacggacac ttcgttgatg tcagaaagtt
     8041 ttatcaggaa aaaacagttg tgtaaggagt gcgcgagatg gaacctttga aatcacatac
     8101 ggggaaagca gccgtattaa atcggatcaa tgtggataca gaccagatta ttcctaagca
     8161 atttttgaag aggattgaaa gaacaggcta cgggcgtttt gcattctttg actggagata
     8221 tgatgcgaat ggtgaaccga accctgaatt tgaattaaac cagcctgttt atcaaggagc
     8281 ttccatttta atagcaggag aaaacttcgg ctgcgggtca tcgcgtgaac atgctccgtg
     8341 ggcacttgat gattatgggt ttaaaattat cattgcgccg tcatttgctg atattttcca
     8401 tcagaactgc tttaaaaacg gcatgcttcc gatccgcatg ccatatgaca attggaaaca
     8461 gcttgtcggc cagtatgaaa acaagtcatt ggaaatgact gttgaccttg aaaagcagct
     8521 gattcatgac agtgaaggca atcaaatttc atttgaagtt gatccgcatt ggaaagagat
     8581 gctgattaac ggatatgatg aaatttcctt aacgctgctg ctggaggatg acattaagca
     8641 atttgaatca caaagaagct cttggcttca agcctgaaaa agcggccggt atttgtccgg
     8701 cggctttttt tgcctgatga aacctttcat ttcttgtgtt tgttcacagg tgttgataca
     8761 cttgaacaaa ataaatgcct gaaaggaata taggtatgac gcatgacaag aagaacgcaa
     8821 aaattattcc ttttcctcat ctgaaagacc gccttgtgga aaaagggatg tcatcactaa
     8881 aggaaaaaaa gtatcaagaa gcgcttgaac tgttttcaga agcgatgaaa tatgatgata
     8941 ctgaatccga tcttcactta gggatggcca tctgcttttt agagctgggc gagctggaag
     9001 aggcaaaaag cgtgtgcgag aagatgctca aagaaggtta tggccattat tttacggttt
     9061 tgcaggtgta catgaccatc ttaattcagc tcaaaaaata cgaggaagtc aaaagcacca
     9121 ttgaagccgt tttggaagaa aatcagctac cggcagaaag cgccgagcaa ttttataagc
     9181 tgctggattt cagccggaaa atgaccgatc cggatcgtga ggacgaggct tgggccgaag
     9241 aatatgagga tacaattgac accgagaaag tgctggcaag ccctgaggag caaatgaatc
     9301 tcattcattc cttaaaagac cgtaacgtag caaagtatac aggattgctc aaaacaatcc
     9361 tccaagaccc ctcagcccac ccgattatca aaacgatgat tgtcatgctg ttggctgagc
     9421 atgagtacag taaacctgtg cacattagca aatttggcga gtcgttgaca attgaaccat
     9481 ctgagattgt tccgcctgat gccgccccga ttctgcaccg tgttctcagg gtgctggatg
     9541 agacacttgg aaatgaaaat ccaaccttat atgcggcagt agaagaattg tggagaagac
     9601 atttatacgt tttatatccg ttccagccga aattgctgtc ggctgacctt tgggcggctg
     9661 ccctgcataa agtcggttac gagatgcacg gaattgaaat tgaaagcgaa gaacttcata
     9721 tgatgtatga atttaccgac agagaactcg atgaagcttg cacaatgtta aaagatattg
     9781 aagaaatttc ttatttgtaa atcgcgccat atagttgaaa gcgctatgtg ttatgttata
     9841 atatagtggt tgtatttgtg tataacgggt tataagaaat acggttggac aggctttgca
     9901 gttcattatt aacatctata cataatgatt ctgatctttg gcagctttgt ttttgttgga
     9961 cgaagccgaa tgattgcttt agaatggaag accgacacaa cctgaataga tttttggagg
    10021 gaaacacatg tctgtaaaat gggaaaaaca agaaggcaac gaaggcgttt taacggttga
    10081 agttgatgct gaaacgttta aaacagcact tgatgatgca tttaaaaaag tagtaaaaca
    10141 agtttcaatt cctggattcc gtaaaggtaa aattcctcgc ggattattcg aacagcgctt
    10201 tggcgtagaa gctctttacc aagatgcttt ggatattctt cttcctgtag aataccctaa
    10261 agcggttgaa gaagctggaa tcgagcctgt agaccgtcct gaaatcgatg ttgaaaaaat
    10321 cgaaaaaggc gaaagcttaa tcttcactgc gaaagtaaca gtaaaacctg aagtgaagct
    10381 tggcgactac aaaggcttag gcattgaaaa agacgacaca actgtaactg acgaagatgt
    10441 tcaaaacgaa ctaaaagcgc ttcaagagcg tcaagctgag cttgttgtaa aagaagaagg
    10501 cgctgttgaa gaaggaaaca cagttgttct tgatttcgaa ggattcgttg acggcgaagc
    10561 attcgaaggc ggaaaagctg aaaactactc tctagaagta ggttctggtt cattcatccc
    10621 tggcttcgaa gatcaattag ttggccttga agcaggtgct gagaaggatg ttgaagtgac
    10681 attccctgag gagtaccacg ctgaagatct tgcaggcaaa ccagctgtgt tcaaagtgaa
    10741 aattcacgaa atcaaagcga aagagcttcc tgagcttgac gatgaattcg caaaagatat
    10801 cgatgaagaa gtggaaacac tcgctgaatt aactgaaaaa actaagaaac gtttagaaga
    10861 agcaaaagaa aacgaagctg acgctaaatt gcgtgaagag cttgttctga aagcttctga
    10921 aaatgctgaa atcgatgtgc ctcaagcaat ggtcgatact gagcttgacc gcatgctgaa
    10981 agaattcgaa cagcgtctgc aaatgcaagg catgaacctt gagctttaca ctcaattctc
    11041 aggccaagat gaagctgcgt taaaagagca aatgaaagaa gatgctgaaa aacgcgtaaa
    11101 atctaacctg actcttgagg cgattgcgaa agcggaaaac cttgaagtat cagatgagga
    11161 agttgatgct gagcttacta aaatggctga agcatacaac atgcctgttg aaaatattaa
    11221 acaagccatc ggttctactg acgcgatgaa agaagattta aaagttcgca aagcaattga
    11281 ttttcttgta gaaaaccgtt aatatggtgc ataataatag tactaataaa acagggcgcg
    11341 aatcattcgt gccttgtttt gtacaattat gagttatctc tttttcttgg ggcaatatag
    11401 ttaatgcagg gctgtttttt gtcatacata tagaatgtgc aagtcagaaa cacattgtta
    11461 ccgtcttttt ggaaagtatg gtaaaatgca atacatactc gttcgtttca agaatcattt
    11521 tcttttgctc tgccggtaaa agaaaaagtg agacaagatt aaggggtgaa agaatgttta
    11581 aatttaacga ggaaaaagga caattaaaat gctcgttctg tggaaaaaca caagatcagg
    11641 ttcgtaagct tgtagctgga cctggtgtat atatatgtga cgaatgtatc gaactctgca
    11701 ctgaaattgt agaggaagaa ctcggaacag aagaagaagt agaatttaaa gacgtaccaa
    11761 agcctcagga aattcgcgaa attttgaatg aatatgtcat cggccaagat caagcgaaga
    11821 aatcacttgc tgttgctgtg tataaccact ataagcgcat taactctaac agcaaagttg
    11881 atgatgttga gctctcaaaa agtaatattt cattaatcgg ccctacggga agcggtaaaa
    11941 cccttctggc gcaaacattg gctcgcattt taaatgtgcc gtttgcgatt gcggacgcta
    12001 catctttgac tgaagctgga tacgtgggtg aagatgtaga gaatattctc ttgaagctca
    12061 tccaagctgc tgattatgat gtggaaaaag ccgaaaaagg cattatctat attgatgaaa
    12121 tcgataaagt ggctagaaaa tctgaaaacc cgtctatcac acgtgatgtg tcaggtgagg
    12181 gtgtacagca ggcattgctt aaaattcttg agggtacagt ggcaagcgta ccgcctcaag
    12241 gtggacgtaa gcatcctcat caagaattca ttcaaattga cacaacaaat attttgttca
    12301 tttgcggcgg agctttcgat ggtatcgaac aaatcatcaa acgccgttta ggccaaaaag
    12361 tgattggatt cggtgccgac aataaagctg ctgatcttga gaaagaagat cttctttcaa
    12421 aagtgcttcc tgaagatttg ctccgtttcg ggttaattcc tgaatttatc ggacgtcttc
    12481 cggttattgc aagccttgaa aagcttgacg aagaagcatt ggttgccatc ttaacaaaac
    12541 cgaaaaacgc tctagttaag caattcaaga aaatgcttga gcttgacaac gttgagcttg
    12601 agtttgaaga agaagcgctt tctgaaattg ctaaaaaagc aattgaacgc aagactggag
    12661 cacgcggact ccgttccatc attgaaggca tcatgcttga tgtgatgttt gagctgcctt
    12721 ctcgtgatga cattgaaaaa tgtgtaatca ccggggcaac tgtgacacac ggagagcctc
    12781 ctcgcctctt attaaaagac ggcactgagg taagccaaga taaaacatct gcataaagat
    12841 aagcacaaac ctcctgagtg gtaacactca ggaggttttt ttgcatgcaa ctcttccgga
    12901 aaaacgttta ttcccgtctt ctatgggaga tactagcaat cagaggaatg aattggatac
    12961 ataaattgtt tttcaggagg gaccaccatg agttggacag ggatcgcgtt atttattcag
    13021 ctgttttttg ggatcatcat cggtttgtat ttttggaatt tgcttaaaaa tcaaaggaca
    13081 caaaaggtca cgatagataa agaatcaaag aaggaaatgg agcagcttcg gaaaatgcgc
    13141 gctatcagct tgtccgagcc attatctgag aaggtccgcc ccaaaagctt taaagatatc
    13201 gtcggacagg aagacggcat taaagcatta aaggcggctt tatgcgggcc aaatcctcag
    13261 catgtgattg tctatgggcc accgggagtt gggaaaacgg ctgctgcgcg gcttgtgttg
    13321 gaagaagcaa aaaaacataa acaatcaccg tttaaagagc aggctgtctt tgtggaactc
    13381 gatgcgacaa cagcccgttt tgatgaaaga ggaattgccg atccgctcat cggctctgtc
    13441 catgacccga tataccaagg ggccggagcg atgggacagg ctgggattcc gcagccgaag
    13501 cagggagctg tcacccatgc ccatggcggt gtgctgttta ttgatgaaat aggggagctg
    13561 catcctattc aaatgaataa aatgctgaag gtgcttgagg acagaaaagt ctttttagat
    13621 agtgcgtatt acagtgagga aaatacacaa attccgaatc atattcatga tatttttcaa
    13681 aatgggctgc cggctgattt tcgcttgatt ggcgcgacca cgagaatgcc aaacgaaatt
    13741 ccgccagcta tccggtcccg ctgtttggag gtttttttcc gcgagcttga aaaggacgag
    13801 ttgaaaacgg ttgccaaaac agcagcggat aaaattgaaa aaaatatctc cgaagaagga
    13861 ctggatcttt tgaccagcta cacgcggaac gggcgggaag ccgtcaatat gattcaaatc
    13921 gcagcgggga tggctg
//
