LOCUS       c00005_gnlPro..        16675 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HLMHPNGB_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 04:17:18
            Original ID  :: gnl|Prokka|HLMHPNGB_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16675
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16675
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3117:6675](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3118..6675
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16675
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16675
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(545..1699)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1906..3084
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLWKDHKVHKGD
                     KNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGFLY"
     CDS             3118..6675
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_3"
                     /sec_met_domain="PFOR_II (E-value: 5e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.2e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.9e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.7e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00025, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-24, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6800..6988
                     /locus_tag="ctg5_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6999..7859)
                     /locus_tag="ctg5_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7887..8717)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-28, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8714..9940)
                     /locus_tag="ctg5_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10413..11699
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11662..11994)
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12022..14775)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.5e-20, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPHFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAKPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15108..16334)
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 ttgagtaaac taattcagtt ataacaaacg aagttgtcaa ctaaaaccag tacacatcat
       61 tccattgctt gaaaccagag tttcatcggt gtgaaactgt agtttcatcg gtgagaaact
      121 agagtttcat acgcttgaaa ctttagttcc aaacgctcga aactatctga aactactgtt
      181 gatttgattg acttaaccgc atgttccaat cacattgaac gcatcagcta cttcaatagt
      241 actgctctct ctgaaaacat taaatcatat atcagtcaat aatacataaa ttatcagtcc
      301 ttaatacttg atttctcaat tattaatatc tgagaaatca aacgttaaca gttgagatat
      361 cagatattaa catcctgtaa atcaaagaat aacacagtaa aaacggtatt tatcaggacg
      421 atgcagagtg agagcaagtc cttgctctca ctctgctacc actggatctc taacagctaa
      481 aacatcgatg aataaaggga tacagacgaa ctgttagagc atgagagcaa aagcactatc
      541 tttttcactg ggggagagta agcaaaagaa acgcacgata ccggctttga ggcgtcaccg
      601 gtactaacgg caaatatccg gcacacaccc gattattctc tacggacaaa gggaacgaag
      661 ccgacatctg ccgatgttcc tccaaagcct gaccggctaa aggataataa tcaatccgaa
      721 aaactccttc cgcatccgca gccaaataac gatccgtcaa gagccatgcc accaccccca
      781 tattcattcg cagattaatt tcgacacaag gatgaatccg gtaaacaggc gcttcatccg
      841 gaaaatgaca aatcatcata tccactccca agtatccatg ataaaagcca ccgaacaaag
      901 ctgacaattc ttcttccaaa cgagtccgca gcctgataaa ttcttcttgt ggcacataag
      961 ccgatagttt ctgcagaatc ttctcgtcag acagcaagtc attccctgca tacatcccac
     1021 tcccacccgt gtggaagacc gaatatccgg caaaaacaac ccttcctctc ccgtcagcat
     1081 aaaactccat agcgaaatct tccaccttat tatatatagg ttcgcctacc accccaccct
     1141 gagaagcagc gacacgggca caccaaccgg aaataaaagt agtaaatatg cctttacacc
     1201 aattcaatcc tttcccgctt ccggaaagcg gagcttttaa caagcacgct tcccgccctt
     1261 cgacgaacgc actgcactcc gccaaagtac tcaaataaaa agattctcca cagaagtatt
     1321 cattcaaccg caacccaggc aacaacttta ccgcctgcag acgatgcgaa tgctctctca
     1381 gaatattcat ataatccgca gaaggcagct ccgtctgatc tgcccccaat gtcatcaaac
     1441 gcttccgcaa agcagggtcc cacccccacg gagagaactt ccggtcttta ccgtcagcca
     1501 cttccggttc cgtcaacaag gccacatcca tgcccaaaag ttcactcttt gttttcagga
     1561 agtccgcatt ataagcagac ggtgcaagca ccgcacttcc cgcttcggca taccacatag
     1621 gaagcaacgc caggtcactc gccatctgtc gggcggaagc cggcgccata tagttcgtct
     1681 caccgcttgc caacgccata tcatgctccg gattgaatat ataaacaggt cttttcgtca
     1741 tgtcaaagat ggattcaaca cattattctg caaatatata caggaaataa tcaggaactt
     1801 acacaataaa gagaaactta taaattaaag cacatttttg ctatctctac tttgcaaatc
     1861 ctaaaaaaag cactatattt gccagccgaa aaacaaagaa acgaaatgga atcattctat
     1921 cgcacacacg cctacctcgt tgagcacacc aatgcccccg ttcgccgcga tcttatggac
     1981 gagatcgact ggagtgaccg tctgattggt atcaaaggga cacgtggcgt aggaaaaacc
     2041 actttcctcc tgcagtacgc caaagagaaa ttcggcaccg accgttcctg tctgttcatc
     2101 aatatgaaca acttttattt ctccggtcac agccttgttg acttcgccaa cgagtttcag
     2161 aaacgtggcg gaaaagtact gctgatcgac caggtgttca aacatcccga atggagcaaa
     2221 gagctacgaa tgtgctatga ccgtttcccc agcctgaaga ttgtcttcac cggttcttcc
     2281 gtcatgcgac tcaaagagga aaacctcgaa ttgcgtgaca ttgcgaaaag ttataacctg
     2341 cgcggattct ctttccgtga atttctgaac ctgcagacag gaatgaaatt ccgggcatac
     2401 agcctcgaag aaatcctcag tacacatgaa cagatagcca aaggagtact ttccaaagta
     2461 cgaccgctgg attattttca ggattacctg catcatggtt tctacccttt cttccttgaa
     2521 aaacgtaatt tctcggagaa tctgctgaaa acaatgaaca tgatggtaga agtggatatc
     2581 ttgctgatca aacaaattga gctgaaatat ctttcaaaga taaaaaaatt actatatttg
     2641 ttggccgtgg acggaccgaa agctccgaac gtgagccaac tggcaagtga cgtacagaca
     2701 tcccgcgcta cggtaatgaa ctatatcaag tatctggcag acgcgcgtct gattaatctg
     2761 gtttacccga aaggagaaga attcccaaag aaaccgtcaa agattatgat gcacaactct
     2821 aacctgatgt actccattta tccggtgaaa gtggaagaac aggatgtact cgacacgttc
     2881 ttcgttaaca ctttatggaa agaccataag gtacataaag gagataaaaa cgtctctttc
     2941 atggtagacg aagtgatgcc gttcaaaatt tgtgcggaag gtacaaaaat aaagaataac
     3001 ccggacgtga cgtatgcgtt gcaaaaggct gagataggcc gcggcaacca aatacctctt
     3061 tggatgttcg gattcttata ctaaaaagat ttatttactt aaatatttaa tttagttatg
     3121 actaaacaga agaaattcat cacatgtgat ggtaaccaag ctgcagcaca tatctcgtat
     3181 atgttctctg aagtagcagc tatctacccc atcactcctt cttcgactat ggctgagtac
     3241 gtagacgaat gggctgccgc aggacgtaag aacatcttcg gcgaaacagt attggtacag
     3301 gaaatgcaat ctgaaggtgg tgctgccggt gcagttcacg gttctcttca ggctggtgca
     3361 ttgactacta cttacactgc ttctcagggt cttcttttga tgatccctaa catgtacaag
     3421 attgccggtg aattcttgcc ttgtgtattc cacgtttctg ctcgtacact ggcttctcac
     3481 gcattgtgta tcttcggtga ccatcaggac gtaatgtcag ctcgtcaaac cggcttcgct
     3541 atgttggcag aaggttctgt acaggaagtt atggatttgg caggtgttgc tcatctggct
     3601 actatcaaat cacgcgttcc gttcatgaac ttcttcgatg gtttccgtac ttctcacgaa
     3661 atccagaaga tcgaaatgtt ggaaaacgac gacctcgctc cgctgatcga ccaggaagct
     3721 ttggctgaat tccgtgcccg tgcactgaat ccgatgaagc cggttgcccg tggtatggct
     3781 gaaaaccccg accacttctt ccaacatcgt gaatcatgca ataactacta tgaagcagtt
     3841 cctgctatcg tagaagaata catgaacgaa atttccaaga tcacaggccg caaatacggt
     3901 ttgttcgatt actacggtgc agaagatgca gaacgcgtaa ttatcgcaat gggttctgta
     3961 actgaagctg cccgcgaagc tatcgaccac ttggtagcaa acggcgaaaa agtaggtatg
     4021 gttgccgtac acttgtatcg tccgttctct gctaaacact tcctggctgc tgtacccaag
     4081 actgcaaaga gcatcgcagt gcttgaccgt acaaaagaac cgggtgctaa cggcgaacct
     4141 ctttaccttg acgttaaaga ctgcttctat ggcgcagaaa atgctcctgt tatcgttggc
     4201 ggtcgctacg gtctgggttc taaagataca actccggcac agatcatctc tgtattcgag
     4261 aacttggcta tgccaatgcc gaagaaccac ttcactatcg gtatcgtaga cgacgttacg
     4321 ttcacttctc ttcctcagaa agaagaaatc gctctgggcg gtgaaggtat gttcgaagct
     4381 aaattctacg gtctgggtgc tgacggtacg gtaggtgcca acaagaactc tgttaagatt
     4441 atcggtgaca acaccgacaa acactgtcag gcttacttct cttacgactc caagaagtcg
     4501 ggtggtttca cttgttctca cctgcgtttc ggtgatactc cgatccgttc tacttacttg
     4561 gtaaatactc cgaacttcgt tgcttgtcac gttcaggctt acctgcacat gtacgacgta
     4621 acacgtggtt tgcgtaagaa cggttctttc ttgctgaaca ccatctggga aggcgaagaa
     4681 ctggctaaga acctgcctaa caaggtgaag aaatactttg cacagaacaa catctctgta
     4741 tactatatca acgcaactca gattgcaatg gaaattggtc tgggcaaccg taccaataca
     4801 atccttcagt ctgcattctt ccgtatcaca ggcgtaattc ctgtagatca agctgttgaa
     4861 cagatgaaga aattcatcgt taagtcttac ggcaagaagg gtgaagacgt tgttaacaaa
     4921 aactacgctg ctgtagaccg cggtggtgaa tacaagactc tgactgtcga tcctgcttgg
     4981 gctaacttgc cggatgatgc aaaagcagaa aacaatgatc ctgctttcat caacgaagta
     5041 gttcgtccga tcaatgcaca ggacggtgac ttgctgccgg tatctgcatt caagggtatc
     5101 gaagacggta cttggtatca aggtacttcc aaatacgaaa aacgtggtgt agctgcattc
     5161 gttcccgaat ggaatgctga aaactgtatt cagtgtaaca agtgtgctta cgtttgtcct
     5221 cacgcttcta tccgtccgtt cgtactcgat gctgaagagc agaagggtgc taagttcgag
     5281 caactgaaag ctgtaggtaa agtattcgac ggtatgacat tccgtattca ggtagacgtt
     5341 ctcgactgtc tgggttgcgg taactgtgcc gacatctgtc cgggtaatcc gaagaagggt
     5401 ggcaaggcat tgaccatgaa acaccttgaa agccagttgg ccgaagctga taactggact
     5461 tactgcgcag aaaacgtgaa gagcaaacaa cacctggtag acatcaaggc taacgtgaag
     5521 aactctcagt tcgcaactcc gttgtttgag ttctcaggcg cttgctccgg ttgtggtgaa
     5581 actccgtacg tgaaattgat ttctcagttg ttcggtgacc gtgaaatggt tgctaacgct
     5641 acaggatgtt cttctatcta ctcaggttca gttccttcta ctccgtacac tatgaacgaa
     5701 aagggtcacg gtcctgcatg ggctaactcc ttgttcgaag acttctgtga atttggtctg
     5761 ggtatggaac tggctaacga aaagatgcgt gcccgtctgg tgaaagtgat gaacgaagct
     5821 atcgcttctg attgctgccc ggctgaatac aaagaagtat ttgctgaatg gatcaacaat
     5881 atgctggatg cagaaaagac taaggaactg gccgaaaaga tcattccgat ggtagaagct
     5941 gctaaagata aatgcaacca ctgcaagcaa atcgctgatc tgcaacaata tcttgttaaa
     6001 cgcagccaat ggatcatcgg tggtgacggt gcttcttatg atatcggtta cggtggtctt
     6061 gaccatgtaa tcgcttccgg taaggacgtt aacatccttg tattggatac tgaggtttac
     6121 tctaacacag gtggtcagtc ttctaaagct actccggtag gcgctatcgc taagtttgct
     6181 gctgcaggta agcgtgtacg taagaaagac ctcggtctga tggctactac ttacggttat
     6241 gtatatgttg ctcagattgc tatgggtgct gaccaggctc agactctgaa agctatccgt
     6301 gaagctgaag catatccggg accatcactg atcatcgctt acgctccatg tatcaaccac
     6361 ggtctgaaag ccggtatggg taagagccag gaagaagaag aaaaggctgt taagtgcggt
     6421 tactggcact tgtggcgtta caaccctgct ttggaagaag aaggcaagaa tccgttccaa
     6481 ctggatagca aagaacctaa ctgggaagac ttccaaggtt tcttgaaggg tgaagttcgt
     6541 tacgcttctg taatgaaaca atatcctgct gaagctgaag aactgtttaa agctgctgaa
     6601 gaaaacgcta aatggcgtta caacagctac aaacgtcttg ccagagaaaa ctggggagct
     6661 gatacagctg aataataagt agaaatactt tgtacataat aaaaggcagg aatcctggaa
     6721 acagattcct gccttttttg tttatatctt agaagtaacg attacttctc acgaagatat
     6781 tcattaaaac tctaaagata tgatcggatt tgttatttgg attatcggtt tgatactgac
     6841 tttcagagct gccatagaga tttggaatat aaatgcggct gtagagaaaa gacttatagc
     6901 gattgtatta atcgttctta ccagctggct gggactactt ttctactact tctatggtaa
     6961 agaaagaatg gcgggatggt tgaagtagtg tttgcatatc aatctttctc aggaatccaa
     7021 ctgttcacca gttcctgatg ttcttccatc cattgacggg cagcctgtct ttccgttgtc
     7081 tgcgcctctt ccagagcagt cattaaggag ctgatttccg catctgtcag acgaatgttg
     7141 cccaaaagtt cggcagcaaa agggtctttc tcgctaaaac ctttccatgc tatggtatga
     7201 atggattccg tatttccata tatcagcttc gggtcctgaa gaactttcag cttgaaacgg
     7261 tcgaacatcc agtgaggcgt ccatcccgtc acgacaatcc agtctttctt atcaatcgct
     7321 ttctttaggg aagcagtcat ggcaggtccg ctcgaagtca tcagtttata atccaatcca
     7381 tagtctttga tggcctgatc ggtagctttc ataataccgg ctccggcatc aataccgaca
     7441 atctgaccgg agaaacgttc cttttccgcg ttcagttctt cgattgagtt gatcgtaacg
     7501 taatccggaa ccaccagccc gatacgggca ccatcataaa tatccccgat aacttcgagt
     7561 ttatccccgt attgtttcat ataatcttcc atagtgacag gcatccagac atccataaat
     7621 acgtctgctt tcttacggga gatagaggta aatataggtg caaggtcggc attcagcaac
     7681 tttacatcgt acccctgatc ttcaaaaatc gctttggcaa ggtttgtcat tgcaatacct
     7741 tccgaccagt tggcataagc gatacttatc ttcttactct ttccgttgtc tccgcaggaa
     7801 acgaaggtta agagtatgcc ggcaataaac attgccgcaa tcatttttat cttattcatt
     7861 gattattcct ttctttggtg tgattcttat ttctttttac tttttctgtt atctgccata
     7921 ccctgagtga tgcggtccag cacgatcgcc aatatcacga ctgcgatacc gccttcaaat
     7981 ccgagtccga ttttcatttg ggtgatacct ttcagcacga tttctcccaa tcctccggca
     8041 gaaatcatgg cagcaatcac taccatcgaa agtgacatca tgatcgtctg gttgattccc
     8101 gtcagaatag taggcaacgc caaaggcaat tgcaccttat aaagaagctg ccagggagta
     8161 gctccaaaag agcgggaggc ttctactacg tttttaggaa cctgacgaat gcccagaccg
     8221 gtcagacgaa ccacaggagg cattgcaaag atgatggtgg caaaagctcc cggcacagtt
     8281 cccaatccga agaatagaac ggcaggaatc agatagacaa aggcaggcat tgtctgcata
     8341 aagtcgagga cagggcgcat tatcttgtta caacgatcac tgttggcagt ccagattccc
     8401 aacggaacgc ctaaaagcaa tgccagacaa gtggaagaaa gtaccaatgc caatgtctgc
     8461 atcgtttctt cccaaaagcc catgccgtaa ataagcaata aacccaagag ggtaaatacg
     8521 gctgtcccct tacccgactt aaaccaggcg agcgcagcca gcactgcaat tgtgatataa
     8581 aaaggtattc caaacagtac gtgctgaaaa ccgtctatga atcctccgat ccccatgctg
     8641 agagcatcaa aaaaggaagc aaaatgttct gtgagccaat taatggcagt ctctatatat
     8701 tgtccgatat ttatcataat tctattgcgt tttgaatgat ttcattaatt tcttctttat
     8761 cttttcccgt tacttcgatg atcaatgagg aaagtggcac tacgccttca aactcccgat
     8821 tctcatttac gacccagatt ggcgagttcg tttttgtcat caacggaaga atatcttcca
     8881 gcaccgtatc acccagcact gaatgaactt catgccttac tacggactcg atggagcgga
     8941 tttgctcttt tcgtagtttc agcaagtcat tcaaccgcac ctctcctact aacagattat
     9001 tggaatcgac taccggaaga acggtcagat tccgttcgcg catcttacgg atcagcacct
     9061 ccgggccttc tttcttcaaa cgtgccacta tgggtttatc taccataaca gaggaagctg
     9121 ttataatctt gcttcgatct acattctcca caaatcgttc tacataagcg ttggcaggtt
     9181 cggtcaggat ttcttccgat gtaccgattt gtacaatttc tccatccttc atgatagcaa
     9241 tccggtcacc caatttaatc gcttcactca ggtcgtgagt aataaagaca atcgtttttt
     9301 tcatcttcga ctgcaaagtc agcagttcat cctgcatctg cacacggatc aaaggatcga
     9361 gtgccgagaa ggcctcatcc atcaacagga cttcgggatt attggccaaa gcccgcgcca
     9421 gcccgacacg ctgctgcatc ccacccgaca gttcacttac catctgattc tcgtagcctt
     9481 tcagccccac cagttgcata ctttccatcg ctttctgctc ccgttctccc ttttttactc
     9541 cctgtagttc gagcccgaaa gctatattat gcaagacaga acggtgagga agcagaccga
     9601 agttctgaaa gaccatagcc agttctttcc ggcgaatctg caacagttcc ttatccgaca
     9661 ctttggctat gtctgttcca ttgataatca cttctccgga agtagggcgt atcaaacggt
     9721 tgatgcagcg gagtaaagtg gactttccac taccggacag ccccataatg acgaatattt
     9781 cgccttcatt aatggaaaga ttcgcatctt tcaccgcaac tgtacatccg gtcgctttca
     9841 atatttcact ttttgtttta ccttctttca acatcttcaa agccttctgc ttctcattgc
     9901 caaaaaccag atagagatct ttaatttcta ttttactcat acaataaaat ggtttaggtt
     9961 attaaaataa tatacacagc aagacaagaa caaacgataa caggaatctt tctttatatc
    10021 gtataaagtt ctgatttaaa taagggacaa ataacaatga atcccgaaat aattaataaa
    10081 atgattattg acagactgag taattaaaaa aggaatagaa tttgataaga taatcctttc
    10141 aacgaatagc aaaaaatagc atttttatgt ataaaaacag cctgttccag tatcttgctg
    10201 gcacaaagat acaaaaaacg gattaaacat acaaattata ttcaaaatcc ggggcataca
    10261 gagggcttta tttgtaatga tatggaaagt ttccgggtaa tattccccta tcactcagca
    10321 aaatagaaca aaccggcaga taaatataaa ataagtttga atatttcact taaacaccgt
    10381 atatttggcg tcaataacta aactagattt atatgttcaa cagggctatt acaattttcc
    10441 tggggaagga taattgtcat tacacaacaa aagaaaaaca aacaggtact gccacactag
    10501 acgacaaaag ccaagtacag ttccttagta aaaagaaccc caaaatgccg tttttctata
    10561 gccggcggaa tctctacatg ataggtttcc tgctcgcttt tatagtgact ctgctcgaat
    10621 ttatacgagg acggcatcaa aactttatgg tcttctcgga cgctactcaa ttcttctggc
    10681 aaggcatcag cccatacaca actgaatttg tagaagctca cggacgctac ttcctttatt
    10741 ctccagtttt cacggtattg ttcgctccgt ttgcgtatct gcctgcatgg ctgggacctt
    10801 tcgcgtggaa tctattcaat tattcgctgt tctttatggc gatcttcacg ctgccccaac
    10861 aattcaccca gcagcagaaa tgccgtatgt tcctttttct gttactgatt ttaggacaaa
    10921 gtttactttc atttcagtat aacataacgg tagcctattt attcttattc gcctatacgt
    10981 tattggaaaa agaccgtgga tttctggctg ttctgttaat catgatttcg ggatgtacca
    11041 aagtatatgg aattttcgaa ctggcattgt tgctgtgcta tcctcacgta tggcgtaact
    11101 ttggctatgc cgttacaatg ggcattgtat tgcttgcatt accgttaata aaaatagctc
    11161 ctgcagattt gctcccctat tatgaagaat ggtgccatag tcttgctgtt catcagtccg
    11221 ccggagctta tgattcattt ttctatgccc gccccattgc agcatggaca ttgccacact
    11281 tccgtgcact tcagatagga atgctcggct tgctgactct gctctttttg gggaatttcc
    11341 gcaaatggtc gtcttttgcc ttccgtgccc aggctttggg cattctcatg ggctgggtag
    11401 tattactgag tgactccgcc gagaagcata cctatattat cgcattggca ggtttcatgc
    11461 tctggtattg gagcagacca acacgtaccg caacagacaa gattctattt tggtgctgtt
    11521 ttgtgctgtt atgtatcgtt cctatcgaca tattcgtccc tgtacccatc agagatttca
    11581 ttaccaggac cttatggctt catgtatggg ttttctttat tgtatggata cggatgatat
    11641 ggcttacctt ccttgcatcc ttcattcatc cacgtgccac aaatgttctt tcagattaac
    11701 gcatccgtta gctttgaaag aaacttcttc tgccagcaag agttgttttt gttccaccca
    11761 accgggcacc agccttccgg tggaatttac aactctatgg cagggaatgg ataattcatc
    11821 cggcacttct ttcaatgcac gtcccaccat ccgcgagcat tggggtgccc ccaacagcaa
    11881 agcaatacct ccataagtag atacttttcc cacaggtatc tgggatacga cttcgtacac
    11941 ttccttccga aaggattcgg aaaagctctc tttatctact ttataatctt tcatatatcc
    12001 ctctttacga tatcaatgaa atcatccttt ccttttcagg aaatctgtcg ggctctctcc
    12061 aaactgctct ttatagcact tggcgaaata agaaggtgaa ctgaaaccga cttcataacc
    12121 aatctccgct acggtcatgt ccgaagaagc aagcaaagaa gctgccttct tcaaacgggc
    12181 gatacggagc aattcattcg gagagtagtt agtcaatgat ttaatcttgc gataaagctg
    12241 cacacggctt agtcccatgt ctttgcccaa gtcctccaca ttcaaaccgg agtctcccat
    12301 tttctcttca atcaatgact tgaatctttc tacaaaatcc ttgtccatat cgcagacatc
    12361 ttcttttgcc aatgtctgcc cgtcaccaaa gaactgtttc agacgacggt gagaatcaat
    12421 cagattgcgg acacgtgcca gcaacagctg tgaactgaac ggctttgaaa tataagaatc
    12481 cgcaccaccg tcatatccct gaatacgctg ttcgtccagt gaacacgctg tcagcagaat
    12541 aaccggaata tgacaggtct gtaactcact tttcagccgg cggcaacatt caatgccatc
    12601 aatgcccggc atcatcacat cagaaatgat caggtccgga acatacttca tagccttacg
    12661 gattccttcg gagccgtctg ccgcttcaat caccgtatag tctgtatgca acaacgtatg
    12721 gacatacgaa cggatatcct cattatcatc aataatcagt acggacggtt tggaagagtc
    12781 atatcctttt tccagttctt cctcttccgc caatagaaca tctgttgtac gggaatccgc
    12841 agaaacaagg gtggtatccg gtttggcagc aacagcctca caagactgta cgggcagttc
    12901 aacggtaaag accgtgccct gtttctcatc actctctacg gagatcatac caccgtgcat
    12961 ttctacgaag gcttttacca atgccagtcc gattcccgaa ccggtatggt gcatatcgat
    13021 cttatagaaa cggtcgaata cattgcgaat atgttcggca gaaatcatgg aaccggtatt
    13081 tgccaccgtg aaacgtatcc atcgcttgtc ctctttacta agggaagaca gacggacggc
    13141 tattttcccg ttttccggtg taaacttaaa ggcattggac agaagattga aataaatacg
    13201 ttccagcttc tccatgtctg ccagtgtatg ataatccgta tccggcatac tatcaaaaga
    13261 aaaatggata tgcttcttac gggctgccgc ctgaaaagac tcattccatc cttcgaaaga
    13321 agaaaggaca tccaccgtaa ccggagtata ttccatcttg ccgttttcat atttacggaa
    13381 atccagaatc tgattgacca gacgcagaag gatattcaca tttcgctgaa tcagcatgag
    13441 catccggtgc tgatctccac tcaatgtctt gtccgccaat aaatgttcta ccgggtcggc
    13501 aaccaatgtc aacggagtac ggaagtcgtg agaaatattg gtgaaaaaga ccagcttggc
    13561 atgggtagct tcttccagtt gatgagagag ctgtatcaat tggtcacgct gttcttccag
    13621 tttgtcacgc tgctcttcca attgctgctt ctgcttaaaa agctctttat tcaagcgatt
    13681 cttagagcgg agtgatttat aaacgaccaa taataagccg gctaccaata aaaggataat
    13741 cagactgccg tataaaacta cctgttgtgt agctacctga gagaggtatc caccgatacg
    13801 tccgttgagc gtttcaatct ttttatcgag ttcggaaatg tgtgtggtct gcaactgcat
    13861 gacgtgtgcg ttggtacggt ccacaacagc ggtattcatc accgtttctt tgggataggg
    13921 tttcttctcc agaatgtcca tagccagttg cagtacctta tcgccattgg tcggatagat
    13981 aaaggtggca tccagcacac tgtccagtac cagttccagt ccgtttccct tacccggcaa
    14041 ggcatctatg ccgacaaaaa tcatttcctt ctcccgccct gccatctttg ctgcctgata
    14101 ggcacccgga gcgatacggt cattatgggc atacacagca tcaatcttag gatgcctccg
    14161 aagcatacta tccatttcta tctctgccgg accacgttcc cacgcagcat ccgctttatc
    14221 aatcagcttt atatccggga atttactgat ggcagccata aatccctgat gccgttccat
    14281 tgcaggagtc gaaccgctca atcctgtcag ttctactata tttcccttcc ctttcagact
    14341 ggaggcaata tagtttccta ccgaacgacc gatttcataa ttatcggctc cgatataggc
    14401 agtatattta tccgaaagaa tcttccggtc tacaagaata acggggatgc ctttctgata
    14461 agcttcttct acaatcggag tcataggagc agcttcgtta gcggaaataa tcagcagatc
    14521 gactccttcg tccataaaat aatggacatc ttccgcctgc ttactgttat catcccctgc
    14581 cgaacggatt tccaccgaaa cgccattata aaacattgct tcccgaagaa tctcatcatt
    14641 catcttatgt cgccatgaat catcgctgca ttgagccacc ccaatacgaa aatggggtgt
    14701 atcctgccgg caagccgtca tcccgattaa accaaacagc accagcatcc acttcagata
    14761 tctcatcgtc ttcatccatc tcatcatttc atagttcttt ctgtaatcca attaagaaca
    14821 aaaataagaa ataatactgt aaagttctct aacttcagct atttattatt ctaaaaagaa
    14881 ggaaagcagt cctctttcag accatcggaa agtattaaca aaagtataaa gcgtaaaaca
    14941 aacacttaat caatgttata aaacatagcg ttttacttgg ataatttgca gatttcacag
    15001 aagtccgtat ctttgcactg tgtttttcat agtattagat ttaaggttaa caaaggttgg
    15061 agcaaggcgt tgctcctttt tttatgccct gacctttcat ctaccggtta gttttcatcc
    15121 cattcctttt ccagtttacc atcaatagtg tagcgtttcc atcgtcctac acggcgacca
    15181 ttcttatatt ccccacattc acgaagctgg tcattcttta cataacgagc ttcgaacggt
    15241 ccgttctgcc ttccgttcac ataggtagaa gtttcccaat aatcaaagcg gttgctcact
    15301 atcagccgtc gttccttgcc atgcaatctg ccggcctgat aggtagcttc atatctcaat
    15361 tcaccatttt ccagattata ttcacggtat aaaccgtctt tacggtcgtt cttcatataa
    15421 tattctttct gccttacccc acttccattg gcaaatgaga catggagtcc atcttctttt
    15481 ccatccagat aggtttcaat catcagcgta tcgccgcttt cggcaaaagt agtccaccga
    15541 ccattcttct ttccattctt ataactaccc agtatacgtg gcgagccaaa cgtaaacacg
    15601 gacgaatatt caccgtcctg caaaccttct tcattgaaat aaacggtctc atacaaatca
    15661 taagtacctt tcagaaaagt atactgtttg cctacctgct tcccgtcctt gtaattatgc
    15721 tctttccgca aagtaccgtc agattcgtac gacagttgct tcccgtgctc tttccccatc
    15781 cggaagtttc tttcactttc cacttttccg gtagtaaagt aacttttgct cgtaccgtcc
    15841 agcttacctt ccttatagga cttttcttct ttcagcttac cgtcaaactt ggagttaatc
    15901 ttgaagaggc catccttccg cccttcttta taacttcctt ccgttattaa tatattgtcc
    15961 acatattctt tgtatccgcc atcataaaaa ccatctttaa aagatgccag cacataggcg
    16021 gaatgataac catctatgat gcgatgttcg ccattcaatg ctttttccgt tttcagttcc
    16081 tgaaacaaca gtctgccatc gcctacatta acaacagata cctgatcgat cttatattct
    16141 ttttgcgcaa acaaaggaag agcaagatat aaaaacaaaa atacgttcca gctttttgat
    16201 ctgaggaagt tcgaaatgtg tttcataaag tagttttctc tttttgattt attatttaaa
    16261 aacctgccgc aaagataggc aatcggctta taaaacaagg caaggaagag ggggacaatt
    16321 agaaaaaaga acatctgtta ttatcattct aataattaac agattaagta gtaaatcaaa
    16381 acacagggaa gggggacatt tactgaaata agaaacagaa aagaagatgt gtcaaaagca
    16441 actaaattcc cctccttcgg gaaggaggag agtttagttg cttttgacac accttctttt
    16501 tgaatttaaa gagattctac aacaatctgt ctttcagaac taccggaagt tcgggcattg
    16561 caccgctctg cgtacaaaca taagcggaaa cttcgacagc cagcttatga gcttcgggaa
    16621 cagacttgcc attcagaatg gaagcacaga aagcggcagt aaaggaatcc cccgc
//
