LOCUS       c00005_gnlPro..        14960 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIIMJMHO_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 09:25:40
            Original ID  :: gnl|Prokka|JIIMJMHO_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 163861
            Orig. end    :: 178821
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14960
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[173861:178721]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14860
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14960
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14960
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="2"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             complement(771..1751)
                     /locus_tag="ctg5_120"
                     /transl_table=11
                     /translation="MDKIYYKELIEKYFDGNITDAEIKELSDWIKNDRHLQNWWEEEFS
                     KSDAGINPVLRDKLFARIKEQTQGKEETQEKEKPRTIRMNPWKWAAAIVLPICIAFFTY
                     YLIDSSQTVGAPFIVKADKGDKATIELPDGTNVVLNSASQLSYLNNFGENVRRVQLNGE
                     AYFKVAHDEKHAFIVQVGDLEVKVLGTSFNVSAYEDAKDVTVVLLEGKVGVYAQKMSHI
                     MKPGDKIEYNKATHKITATQVHPSDYIEWTKGNIYFEKESLENIMKTLSRIYDVEIRFD
                     SNKLPNEYFTGTIPVGGIQNALNILMLTSPFYYEMDGSVIVLKEK"
     CDS             complement(1819..2415)
                     /locus_tag="ctg5_121"
                     /transl_table=11
                     /translation="MVNFTDEKHLLIDLKDGSFQAFERLYNMYSGKLYNFIMRLSSGNQ
                     YMAEEVVQSTFIRIWEVREKVDTNASFISFLCTIAKNLLMNMYQRQTVEYVYNEYLLKS
                     SVDRDSQTEENIDLHFLNDYIDSLAEELPAQRKKIFILSKRQNYTNKEIAEMMGISEST
                     VATQLSLAVKFMREQLMKHYDKVIALLIAFFVNEM"
     CDS             complement(2628..3926)
                     /locus_tag="ctg5_122"
                     /transl_table=11
                     /translation="MEEKELWMNKLKEKLADYSEPVPASGWEQLEKELMPPVEKKIYPY
                     RKWMMAAAAVILLAVVSSVSLYFLGTPAADEIRHIKTPALASTPDALPGVQQPDVQGTS
                     VEPVLRPVAREDRLAKIDKNLTEQKTNAGQSAIENNNEPVTGNENNPVIEEDQMLKGET
                     EQTKNEARQVDSENVGQATQSQDTERPNNRPRRPSGRDKLHIPAEKRASQKGTWSMGLS
                     VGNSGGASTEVGAGSHAYMSRVSMLSVSNGLMEIPNDQTLVFEDGVPYLRQAKQVVDIK
                     HHQPISFGLSVRKGLAKGFSLETGLTYTLLSSDAKLAGEDQQIEQKLHYVGIPLRANWN
                     FFDKKLVTLYVSGGGMVEKCVYGKLGSEKETVKPLQFSVSGAVGAQVNATKRLGIYVEP
                     GVAYYFDDGSDIQTIRKENPFNFNIQAGIRLTY"
     CDS             complement(3933..4481)
                     /locus_tag="ctg5_123"
                     /transl_table=11
                     /translation="MEELELSEQCRLGNNQARKELYEQYAGRMLGICLRYTGDRDTAQD
                     LLHDGFLKIFDSFDKFTWRGEGSLRAWMERVMVNTALQYLRKNDVINQSAPLEELPEEY
                     EEPDASDVEAIPQKVLMQFIEELPAGYRTVFNLYTFEDKSHKEIAQELGINEKSSASQL
                     FRAKSVLAKRVKEWITHNG"
     CDS             4658..5380
                     /locus_tag="ctg5_124"
                     /transl_table=11
                     /translation="MKKFKFIAFIFAIMTTMPILQSCLDDDDNPSDLLVVSTINMISQD
                     SKEFYFTLDDGKKMYPSNAQGWSNKDWVEGQRAFVIFNELEEPVNGYDLNIQVRGINPI
                     LTKDIITMGEDDNDEEKVGDDKINTTYMWINKDNKYLTIEFQYYGTHSEDKKHFLNLVI
                     NDKEESAPTADEDSAEDEYINLEFRHNSEGDYPQSLGEGYVSFKLDKIKDRMEGKKGLR
                     IRVNTLYGGPKTYEVKFP"
     CDS             complement(5793..6719)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     61.1; E-value: 2.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg5_125"
                     /sec_met_domain="LysR_substrate (E-value: 2.3e-43,
                     bitscore: 141.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 5.1e-19, bitscore: 61.1,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIQQLEYILAVDQFRHFARAAEYCRVTQPTLSAMIQKLEDELGV
                     KLFDRTVQPVCPTPIGQKVIDQARVILAQAAQVKEIISEDKQSLSGVFRLGVLPTIAPY
                     LLPRFFPQLMEKYPELDIRVTEMKTQDIQQALHAGDLDAGIIASKLEDTFLTEETLFYE
                     QFYAYVSRKEPSFKHDVIRTSDITGEHLWLLDEGHCFRDQLVRFCQMEAVKVSQMAYRL
                     GSMETFMRMVESGKGITFIPELAVAQLTEEQRQLVRPFAIPRPTRQVVLATNRDFIRHS
                     LLCVLKEEIKAAVPKEMLTLQSIQCLL"
     CDS             6858..7334
                     /locus_tag="ctg5_126"
                     /transl_table=11
                     /translation="MKTLEFIKLNESGANNVVASLQQLLADFQVYYTNLRGFHWNIKGH
                     DFFVLHSQFEKMYDDTAEKVDEIAERILMLGGTPANKFSDYLKVANISEVDKVSNGEQA
                     LNNILQSISYLIGEERKILSIASQAGDEVTVSMMSDYLKEQEKLVWMLTAYNSK"
     CDS             complement(7645..8781)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 57.1; E-value: 4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_127"
                     /sec_met_domain="AMP-binding (E-value: 8.5e-18, bitscore:
                     57.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRKQQRLLLEGKEYTFEDISRLIAGGAEAHSPASWDLYLFLN
                     EWFNDSPVIIVHTSGSTGTPKELIVRKDQMMQSARLTCEFLDLKKGETALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTLQVPEEKERLKQTD
                     ILIIGGGAIDEALEAEIKHLPTAVYSTYGMTETLSHIALRRLNGTLASEHYYPFSSVKL
                     SLSVENTLIIDAPLVCDEILQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRSFIPVPFVITSVPDQRLGQAVTLLLEGQPELLEGQPDTKEIGNKLQEILEPYYRPKY
                     IWTTDCIPQTENGKVNRAKCRILAKQMLTTFYTHTLTP"
     CDS             complement(8803..9828)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_128"
                     /sec_met_domain="MR_MLE_C (E-value: 2.2e-27, bitscore:
                     89.1, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILVKVCRKVEREQGRLDMDGLCDYPSILFGLETAIRHFF
                     AGNWALCDTAFSRGEVGIPINGLIWMGDFQNMLSQIEKKMEAGFRCIKLKIGAINFEEE
                     LTLLRHIRTHFSSKEIELRVDANGAFSPVDAMEKLKRLSEFDLHSIEQPICAGQWEEMA
                     RLAAESPLAIALDEELIGCNTLERKQELLSTIRPQYIVIKPSLHGGICGGDEWITEAEK
                     QQIGWWITSALESNIGLNAIAQWCATFSNPLPQGLGTGALFTDNVEVPLEIRKDCLWFC
                     K"
     CDS             complement(10001..10825)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_129"
                     /sec_met_domain="ECH_1 (E-value: 1.2e-81, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(10829..12496)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_130"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-06, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(12516..13631)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_131"
                     /sec_met_domain="Chorismate_bind (E-value: 5.5e-57,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPMDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             complement(13628..14860)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_132"
                     /sec_met_domain="HBT (E-value: 2e-17, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDMKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
ORIGIN
        1 ctaactcctt tttagtaata ccacaaatat tggcgtatgg aattttcata cttatatcat
       61 tcagctgatt caaatcactg aacacactta cttgggcaaa ttttgtgact cctgtcaaga
      121 atataaaccg aagatagcgg tcggaacttt tcagtacacc ataaaaggct ttcagaatac
      181 gacggtattc atccaacagg ttctcatcta aaagggcttg cagcaaaggt ttatcatact
      241 catcaaccaa taccacaact ccttttcctg ttttcagata ggcttgctca atgatataac
      301 taaaacgttc ttcaggacta cggtctttct tctcatcacc atatacggct tcccatttct
      361 ccaaatactg gtttagcatg gcaaccaaat ctgccgccgt ctcatatttc ttcgcattca
      421 aatcaagatg cagaaccgga tattgctccc acttcgtctc taacttttca attgccaagc
      481 cttcaaaaag gtctttacga ccctgaaaat aggcttcaaa agtggaaatt agcagacttt
      541 tgccaaaacg acggggacga ctaagaaaat aaggcacttt agtagctgct atctgatata
      601 taatggctgt tttatccaca tacaaacacc cctctgcacg catcttttca aatgtctgta
      661 tccctatcgg caatttacgt tccaatgaat tcattgcatc ttcaaattag tgtaccacaa
      721 atatagacgt tattcgatga ataaacaaag atactctatg aaagttccac ttatttctct
      781 ttcaaaacaa tcaccgaacc gtccatttca taatagaaag gtgaagtaag catcaggata
      841 ttcaatgcat tctgtatgcc accaaccgga atggttccgg tgaaatattc attaggtagt
      901 ttattggagt cgaaacgaat ctctacgtca tagatgcgtg aaagggtttt cattatattc
      961 tccaaagatt ctttctcgaa atagatattt cctttcgtcc attcaatgta gtcactcggg
     1021 tgtacttgag tggctgttat cttatgagtg gctttattat attctatttt gtcgccgggc
     1081 ttcatgatat gcgacatttt ctgcgcatag acccctactt ttccttccaa aagaacgact
     1141 gtcacgtctt tggcatcttc ataggcagat acattaaaag aagtaccgag tactttcact
     1201 tccaaatcac cgacctgcac tataaaggca tgtttttcat catgagctac tttgaaatag
     1261 gcttcaccat tcagttgcac acgacgcaca ttttctccga agttattcag atagcttaat
     1321 tgcgaagcag aattgagaac gacattcgtt ccgtccggca attcgatggt tgctttatct
     1381 cctttatcag cttttactat aaagggtgct cccactgttt gggaagaatc tataagatag
     1441 taggtgaaga aggcaataca aatgggtaaa acgatggcgg cagcccattt ccaaggattc
     1501 atgcgaatag ttcttggttt ctctttttcc tgtgtctctt cttttccctg cgtctgttct
     1561 ttgattcggg caaatagttt gtcgcgcagt accggattaa taccggcatc cgatttggaa
     1621 aattcttctt cccaccagtt ctgtaaatgg cggtcgttct ttatccaatc ggaaagttct
     1681 ttaatctccg catccgttat atttccatcg aaatactttt caatcagttc tttataatat
     1741 atcttatcca tcttctttcc tgcttattta caagtataca ttttcatcct atctactatc
     1801 caaaaacatg tattacaatt acatttcatt aacaaaaaag gcgatcagaa gcgcaattac
     1861 cttatcgtaa tgcttcatca actgctcacg cataaatttc accgccaaag ataattgtgt
     1921 ggcgactgta ctttcagaaa tacccatcat ttcagcaatt tccttattcg tatagttctg
     1981 acgcttactt aagataaaga ttttctttcg ctgtgccggc aattcttccg ctaatgagtc
     2041 gatatagtcg ttcaagaaat gaagatcaat attctcttct gtttgcgaat cacgatccac
     2101 actgcttttc agcagatatt cattgtaaac atattcaacg gtctgacgct ggtacatgtt
     2161 catcagtaaa tttttggcta tcgtacaaag aaaagaaata aatgaagcgt tcgtatcgac
     2221 tttctcacgt acttcccata tacggataaa agtggattgc accacttctt cagccatata
     2281 ttgattgccg gaagaaagcc gcataatgaa attatacagt ttaccgctgt acatattata
     2341 caatctttca aatgcttgaa aagaaccgtc ttttaaatcg attaataaat gtttttcatc
     2401 tgtaaaattc accatagctt agaattttgc aacaaaggta tgcaaccata gaccattaac
     2461 aggtgacaat attattaata ttttctcaat tatccgattt ttatgaggaa aaagatacta
     2521 atatcaggat agtgacgcca tccggtcaag atagtgacgc tatctaatca ggatagtgac
     2581 gctatcttga acggataccg tcactatgtt cagtatggta attcgcatta ataagtcaaa
     2641 cggataccag cctgtatatt gaagttaaac ggattctctt tacgtatggt ctgtatatcc
     2701 gaaccgtcat caaaataata agcaacaccg ggttctacat agatacccag acgtttcgtt
     2761 gcgttcacct gtgcacctac cgcaccagat accgagaatt gcaaaggttt caccgtttct
     2821 ttctcggaac cgagctttcc ataaacacat ttctccacca tacctccacc ggagacgtag
     2881 agagtgacga gttttttatc aaagaaattc cagttagcac gcagcggaat accgacataa
     2941 tgaagttttt gttctatctg ctgatcttca cccgccagtt tcgcatccga agaaagcaat
     3001 gtgtaagtca atcccgtttc gagagagaat cctttggcca gtcctttacg gacagacaat
     3061 ccgaaagaaa taggttgatg gtgcttaatg tcgaccactt gttttgcctg acgcagataa
     3121 ggcactccat cttcaaaaac caatgtctga tcgttaggta tctccatcag accgttggaa
     3181 acagaaagca tactcacacg agacatataa gcatgagagc cggcaccgac ttctgtggat
     3241 gctccgcccg aatttccgac cgagagtccc atggaccatg ttcctttttg agatgctctt
     3301 ttttctgccg gaatatgcag cttgtctctg ccggaagggc gacgcggcct gttgttcggc
     3361 cgttcggtgt cctgtgactg tgtagcctga cccacatttt cactgtcaac ctgccttgct
     3421 tcatttttcg tctgttccgt ctcacctttg agcatctggt cttcctcaat cacaggatta
     3481 ttttcattcc ctgttacagg ttcgttgtta ttttctattg cagattgacc tgcatttgtt
     3541 ttctgttctg taagattctt atcaattttc gccaaacggt cttcacgagc cactggtcgc
     3601 aagacgggtt ctacggaagt gccctgcaca tctggttgtt gcacacccgg caacgcatcg
     3661 ggtgtagatg ccaatgccgg agtctttata tgacgtattt catccgcagc cggtgtcccc
     3721 agaaaatata gacttaccga cgaaacgaca gctaacaata taacagctgc agcagccatc
     3781 atccattttc gataaggata tattttcttc tccacaggag gcataagttc tttctccagt
     3841 tgttcccaac cggaagcagg caccggctcg gaataatccg cgagcttctc cttcaactta
     3901 ttcatccaca attctttctc ttccatctct atctatccat tatgcgttat ccattctttt
     3961 actctttttg ccaatacact cttcgcacga aatagttgcg aagccgaaga tttttcatta
     4021 atacctaatt cctgtgcgat ttctttatgc gatttgtctt cgaatgtata aaggttaaac
     4081 actgtacgat atccggcagg tagttcttct ataaactgca tcaacacttt ctgtggaata
     4141 gcttctacat cagaagcatc cggttcttca tattcttcag gcaactcttc taatggtgcc
     4201 gactgattga ttacatcatt tttccggaga tattgcaaag ctgtgttgac catcaccctt
     4261 tccatccagg cccgcaggga gccttcaccc ctccaggtga acttgtcgaa ggaatcgaat
     4321 atctttaaaa aaccgtcgtg aagcagatcc tgggctgtat cacggtcgcc ggtatagcga
     4381 agacagatgc caagcatacg tcccgcatac tgctcataca gttctttgcg agcttggtta
     4441 ttgcctagcc tgcattgttc cgacaactct aattcttcca ttctcttata cacgtgttta
     4501 acttataaat gcagcaaaga tagaaatact gcatagagag aacaactctt ttatcacttt
     4561 tgtttcttta acagattcaa atgcaatatt ttctattcca ctgcattttc acaatacaaa
     4621 ggaaccattt tatataatct aaaacttaaa taagtatatg aagaaattta aattcattgc
     4681 ctttatcttt gctattatga ctacaatgcc gattctccag tcatgtttgg acgacgatga
     4741 caacccgtcc gatcttctgg ttgtcagtac catcaatatg attagccagg atagcaagga
     4801 attttatttc actttggatg acgggaaaaa gatgtatccc agcaatgcgc aaggatggag
     4861 taataaagat tgggtggaag gacaacgagc ttttgtgata ttcaacgagc tggaagagcc
     4921 tgtgaatgga tacgacctta atattcaggt gagaggtatc aatccaatct taactaaaga
     4981 catcatcacg atgggtgaag atgacaacga cgaagaaaaa gtcggagatg acaagatcaa
     5041 cacaacttat atgtggatca acaaggataa taaatatctg acgattgaat tccaatatta
     5101 tggaacgcat agtgaagata aaaaacattt cctgaatctc gtaatcaacg acaaagaaga
     5161 gtctgctccc actgctgacg aagacagtgc ggaggacgaa tatatcaatc tggaattccg
     5221 ccataacagt gaaggtgatt atcctcaaag cctgggcgaa ggatatgtat ctttcaaact
     5281 ggataagatt aaagaccgga tggaagggaa aaaaggatta aggatccgtg tcaacacttt
     5341 atatggcgga ccgaaaactt atgaagtaaa gtttccctaa gattataaat ctaatgtaaa
     5401 cgtgcaaaac acactctttt ttaatataat atattaatta cgcaaaagag ggcggtagtt
     5461 gtgaaactgc cgccctttta tctttatata agaagttatt cttataaagg gaagtccctg
     5521 tgatgggaat acatacaata tgtaccaata caagagtcaa accgatggca agtcctgcca
     5581 gattgcccgc tcccctcttc gaatcggtag agccgagcac cactaataca aaaatgaaag
     5641 caaagacaag ccaataaaat gaacaaagga cttttttaca tcatatttgc ctctaccaca
     5701 tggagcacat cgtaaacaca tttatcaagc aaggatcgag ctatgacttc actcctatga
     5761 atttctccgg aatcctctca atctcctatt tattatagca aacattgtat ggactgcaaa
     5821 gtaagcattt ctttggggac tgcagctttt atttcctctt tcagaacaca tagcaggcta
     5881 tgacgaataa aatctctatt tgtcgccaac accacttgcc gcgtcggtcg ggggatagca
     5941 aacggacgta ctaattgtcg ctgttcttcc gtcaattgag ccactgccag ttcgggaata
     6001 aaagtgattc cttttccgct ttctaccatt ctcataaagg tttccatgct tcccaaacga
     6061 taagccatct gactaacctt caccgcttcc atctgacaga aacggacaag ttggtcacga
     6121 aagcaatgtc cttcgtccaa aagccaaaga tgttcgccgg ttatatcgga agtgcggata
     6181 acgtcatgtt tgaacgaggg ttctttccgt gatacataag cataaaattg ctcatagaag
     6241 agagtttctt ccgtcaagaa tgtgtcttct aatttactgg caataatccc tgcatccaaa
     6301 tcgccggcat gcagagcctg ctgaatatcc tgggttttca tttccgtgac acgaatatcc
     6361 agttcgggat atttctccat cagttgaggg aaaaagcggg gtagcaaata aggagcgata
     6421 gtgggtaata ctcccaaacg gaatacacct gataatgatt gcttatcttc actgatgatt
     6481 tcttttactt gagctgcctg cgccagaatc acacgagcct ggtctatcac tttctgcccg
     6541 atgggtgtcg ggcagacggg ttgcactgtc ctatcgaata actttactcc caattcatct
     6601 tccagcttct gaatcatggc actcaaagta ggttgcgtca cacggcaata ttcggctgcc
     6661 cgtgcgaaat gcctgaactg gtctacggct agtatatatt ctaattgttg tatcgtcatc
     6721 tatcaaatca tattaagtta tagatttcat ctatgcaaag atagaaattt tcagtttgac
     6781 aacaagcatt ttccgcctta tctttgcagt acagaaaaaa aagaaaacaa gtataaatca
     6841 ttaaaaataa aaagaatatg aaaactttag aatttatcaa actgaatgaa tcgggagcaa
     6901 acaacgtagt agcatctttg caacaactat tagcagactt ccaagtgtat tacaccaatc
     6961 tccgcggttt ccactggaat atcaaaggac atgatttctt tgttctccac agccaattcg
     7021 aaaagatgta tgatgacaca gccgaaaagg tagacgaaat tgcagaacgt atcttgatgt
     7081 tgggcggtac tcctgccaat aaattcagcg attatttgaa agtagcaaat atcagtgaag
     7141 tagataaggt gagcaacggc gaacaggcac tgaacaatat ccttcagagt atcagttatc
     7201 tgattggtga agaacgtaaa atcttgtcta tcgcttctca agccggagat gaagtaaccg
     7261 tttcgatgat gagcgattat ctgaaagaac aggaaaaact agtttggatg ttgacggctt
     7321 ataatagcaa ataattaaga taaaaggttt aggtttttaa gtgagaaaga gaggatattt
     7381 ccgtaaaagg aatattctct ctttattatt tccagtgtac tagtactatc taaatacgtt
     7441 cattcgctga tattattaaa aaaattagtt ttgttcttta tttatcaaga tttataaaag
     7501 taagcaacaa ctttcaaaag atgaaactta ttctactgaa ataaaatgtc ttaccctgaa
     7561 ttttgttgac tctaataagt ctcaactaaa actagggtaa gacaattaga ggcccctgaa
     7621 acgttgatga ataaaggatt tcaatcaagg tgtgagagtg tgagtgtaaa acgtcgtcaa
     7681 catttgtttg gctaaaatac gacacttcgc acgattaacc ttgccgtttt ctgtttgcgg
     7741 aatacaatct gtcgtccata tgtacttggg acgataataa ggttccaata tttcctgtag
     7801 tttgtttccg atttctttag tgtccggctg accttccaat aattctggct gaccttccaa
     7861 tagtaaggtt acagcctgcc ctaaacgctg gtccggaact gaagtaataa caaatggcac
     7921 aggaataaaa gaacgaagca atttctccat ttcctccgcc tgaatcttaa ttcctccact
     7981 atttatcaca ttgtctttcc gacccaaaat cataaaactt ccatcgggat agatgcgtgc
     8041 aatgtcattg gtttgcaata tttcatcaca taccaaaggg gcatcaataa ttaacgtatt
     8101 ctctacagat aaagacagtt ttactgaaga aaacggataa taatgttccg aagccaatgt
     8161 tccgttcagc cgacgaagag caatatgaga taaagtttca gtcatgccat aggtagaata
     8221 gacggcagtc ggaagatgtt tgatctccgc ctctaaagcc tcatcaatag ctccaccacc
     8281 tataatcaaa atatccgtct gtttcaatcg ttctttctct tcgggaactt gcaacgtatt
     8341 ataaacttgc aggggaacca ttgccacaaa tctcaaaggc tcttttatat ccgctaaagg
     8401 atgaccggaa gcaggacgta caatcaaatt caagcctgca accaacgaac gcacgaccac
     8461 catcattgca ccaatataac gaagattcat acaaagtaat gccgtctctc ctttcttcaa
     8521 atccagaaac tcacaagtca gacgcgcact ttgcatcatc tggtctttac gtacaatcaa
     8581 ctctttaggt gtacccgtag agcctgatgt atgaacaatg atgacaggag aatcgttaaa
     8641 ccattcgttc aggaaaagat ataaatccca actagcagga gaatgagcct ccgctcctcc
     8701 tgctattaat cggcttatat cctcaaaagt atattctttt ccttccagta acaagcgttg
     8761 ttgttttcga tcgaatatca tcggaatatc ctttaaatac tatcatttac aaaaccataa
     8821 acaatctttt cttatttcaa gaggcacttc cacgttgtct gtaaagagcg cccctgttcc
     8881 cagtccctgt ggcaacggat tgctgaatgt tgcacaccac tgggcaatgg cgtttagccc
     8941 aatgtttgat tccagagcgg aagttatcca ccagccgatc tgttgttttt cagcttcggt
     9001 aatccattcg tctcctccgc atattcctcc atgaagagaa ggtttaataa cgatatattg
     9061 cggacgaatt gttgaaagca gctcctgttt cctttccagc gtattgcatc ctatcagttc
     9121 ttcatccaaa gcaatcgcta atggagattc ggcagcaagc cgagccattt cctcccattg
     9181 tccggcacag attggctgtt cgatagaatg taaatcaaac tcggacagac gtttcagttt
     9241 ttccattgcg tccacgggtg agaaagcacc atttgcatct acacgcaact ctatttcttt
     9301 agaagagaaa tgcgtacgaa tatggcgcaa caatgtcagt tcttcttcga aattgatggc
     9361 acctatcttt aacttgatac aacgaaatcc ggcttccatc tttttctcaa tctgggataa
     9421 catgttctga aaatctccca tccaaataag gccgttaatc ggaataccaa cttctccacg
     9481 tgagaaagcc gtatcacata aagcccagtt tcctgcaaag aaatgccgga tggccgtttc
     9541 cagaccaaat aaaattgaag gatagtcaca caagccatcc atatccaatc tgccttgttc
     9601 cctctctact ttccggcaga ctttcactaa tatatcttcg taatcaggaa gatcgtcaca
     9661 acttaaagcg ggcaaaggtg cacactcccc tattcccact ctgccaggga agtcaggaga
     9721 ggtaaaatga agataccaaa ctttacgcgt agtatatgtt cctctggaag tcccggcagg
     9781 ttgcttgaaa tggagcaatc ggggaataat ttctatttta caattcatcg tgaataattt
     9841 ttcaattcac cacagaataa cacagagcct cacgaagttt taataagtta tatctcttgc
     9901 agttctccta ccattctctc ctccacagtc ttgctttgca gaaaatcggg cttaaacgca
     9961 ggaaaagcaa actctgtggt actctgtggc aaagccgatt ttaagggaat ttcggatatt
    10021 gtttgaagtt cggtttacgt ttctccagaa acgcattctt tccttcctgt gcttcatcag
    10081 tcaggtaata gagcaacgtt gcgtcacctg ccaattcctg aatacctgcc tgaccatcca
    10141 gttcggcatt caatcctgct ttaatcatgc gcaaagccaa cggactaagc aacatcattt
    10201 cttctgccca ctgcacatat tcgtcctcca actgctccaa aggaactact ttattcacta
    10261 atcccatgtc caatgcttct tgtgcattat acttccgaca gaggaaccag atttcgcgtg
    10321 ctttcttctg acctaccaca cgtgccagat aagacgcacc gaatccggca tcaaagctac
    10381 ctacacgagg acccgtctga ccgaaaatag cattttccga cgcaatggac aaatcacata
    10441 ccacatgaag cacatgtccg ccaccaatag caaaaccgtt cacggcagca atcaccggtt
    10501 tcgggatgct gcgaatctgc ttttgcacat ccaatacgct aagacgaggc acaccgtctt
    10561 ttccgatata tccgccacgt cctttcacat tctggtcgcc acccgaacaa aacgccttat
    10621 caccggctcc ggtaatcaca atcacatcaa tatccgcttc ttcacggcag atgcgcaatg
    10681 cgtcactcat ttcagcagta gttgtcggag taaacgcatt ccgatagcgt tcacggttga
    10741 tcgtgatacg ggcaattcca ttataataat caaaaagaat atcgtcgtat tctctgatgg
    10801 ttgtccactc tctttgtgtt gacataatct atttttgttt taattgatga taataattct
    10861 tcaacatgcg cgcgtccttg tttttgttgg taaacacctc caagagcaca ggctgctcca
    10921 tagcttccgg ttgagtgaaa gttttcatcg cttcagccag ttcttcgtca ttttgcgctt
    10981 gcagatagag aaacccacgc tcttctgccc aacctttggc ggacgtttta tggactgccg
    11041 caataaattt atgtgaggta cccgacatat ccaatcccgg caaggtatgg aaaatctctc
    11101 ctcctccatt atttaacaga agaacacgca gattggagcg aacattgacg ttccacaacg
    11161 cattcatatc ataaaagaag ctcaaatctc cgatagctat aaagttcagt ttgtcggaag
    11221 ctgccgcata accgacagcc gtagacagtg agccttcaat gccgtttgtc ccccggttgc
    11281 aacaaacttc aatcgtagaa ggaatagagt ataattgtgc atagcgcacc accgaactgt
    11341 tagccagatg caacgcacat gactccggca aggctttcaa taacgtaccg acggcagaca
    11401 tttccgaata agcaaactcc ggttcgggaa tgatcttgca atagttttcc cacacacggg
    11461 gatattcagg agtccgattg tccaacaaac tggctatctt ctccagaaac tcgaacgggt
    11521 ccatttcgat caccgtagtt aatgagccgt acaaatcgac cacctcacca tccggcgata
    11581 cgtgccaatg ttctttaggc ggatgctgac ggagaaactt cttcagccgt ttggaaacga
    11641 catgtcctcc ataagtaatc agcaactccg gaaccatctg cccgaccttc tcttcgggca
    11701 tggcataaag cgccgcatca aagttcttta ccggaatacc gggaactgtc tggttgccga
    11761 tatgttccgt caaccaggca aaatgtttat ataataactt gatatatctt ttttcaaaca
    11821 ggtagataag attcatctga ccgataataa tcattcgctt ctggtattta ttcatccgat
    11881 cgaccaaatc gttataatca cgatcgtaga cgttcaaccc ctgataacgg gtaatgacac
    11941 gcacttcagg aagcgaatca accgtaaact ggaacaacgg ttcagaaata gggacattga
    12001 tatgtaccgg tccttttcca tgatggttcg tttccagcaa agcttcattc accagacgat
    12061 tgcaatacca ttcatcttct tccgtatgaa tctccggaag gtttaccgac ttcttaacta
    12121 atgtctgaaa tacgcctggt tgtggtactg tctgtccatc catctgcccg atccaggcag
    12181 cgggacgatc cgcagaaata atgaccagag gaacattttg ataaaaagct tctgccacag
    12241 ccggatgaag gtttaataat gcagtaccgg aagtgcaaca gacagctgcg ggcttaccac
    12301 cattcaacgc aagaccgatg gcaaaatagc cggcactccg ttcatccgtc accggatagc
    12361 aggtaaaatt cggatggtta gacaaagtat gtactatggg cgtattccga ctacccggac
    12421 acaacacaac cttagtaatc ccatgcgcct cgagcaacgc aaccaactgg agtatgttct
    12481 tcttgtctgt atacatgatg ataattatta gtagtttatg attttaaagg aggcactgca
    12541 atcagccgtt tgatagtttg caacttcttc tccgtttcca gccattcgtc attcaattcc
    12601 gaagaggcca ataatccacc gccggcataa agagtaagtt gtttatcttc gatatgcata
    12661 cagcgtaagt ttacatagat gtctgttcgt ccttccggat cgagccatcc gataaagccg
    12721 gagtaatagc ggcggtcgta accttcattc tgcaaaataa actgataggc ttcttccttc
    12781 ggcaagccgc atacggcagg tgtcggatgc aaaactttca gaaggtctcc caaaccttta
    12841 ttatctttca aagaaaaacg gaaatcagtt tttaaatgtg acaaagcacc ggcataagca
    12901 ggatatggcc cgttttccgt agaatgaata tccagtgaaa gaagctgccg acggatataa
    12961 gaagcaacat aatcttgttc tttccggttc ttttcatccc atacttgcgg caatctgcca
    13021 tcttgcaaag gctgtgttcc ggctagtgca accgtatgcc attcgtcttt ctcacctgat
    13081 aaaatgattt cgggagtact tcccagccag atgcccgtct gcggagtata acataagtaa
    13141 atatacgaat gaatataacg tttacaagcc gcccgaaaga tggacaaagg agaaaaatcc
    13201 gcaactttat caactgtaag atgacgggaa agcactagtt tatcaaacgt cctgtcacgt
    13261 aacgcattta taaaggtatg aaagcatgcc gcatattctt ccgtagaaga agtcagaaat
    13321 gattcttgtc cttgcaggcg caaggctatc tcccggtctt cttccgtatc atcatccatc
    13381 ggtaaaggct gcccccactg atcgggttgg atcaacacaa ccggacatga ctcactcacc
    13441 tgaaacggag caattacaaa tcctctctgt ccgttcagtt ctttcaaatc gtatatcaaa
    13501 cggaccgctc cttccgcctg cgtcaacaga cggggaacct tctctccggg aatacggtaa
    13561 acagcaaacg gctgcttccg ctgaataaat gcatcaatag ttgtcaagtt acttatttct
    13621 tcgtcggtca tctctttttc atcacactgt tgactacccg tatggaagac accagtttgt
    13681 ttgttgaagt aaacacgtct acattccata cgtgggagga acgtccctta tgtacaactg
    13741 ttcctaccgc acgcactgta tctccttcat gtgcagaaga tatatggttt ccgctgacct
    13801 gcattcctac tacaatctcg tccggctggc aaagaatcat cgaaccgagt ccggcaactg
    13861 tttctgccag tgcaagagta gctcccccat gcaaaatgcc gaaaggctga cgggtacgat
    13921 ggtctaccgg catcgttgct tccacacggt cttcgtcggc gtatgtatat tgaattccca
    13981 agtttcccat taatgcgtgg cgtgcctgcg cattcagttg gtcaagggga atttcggctg
    14041 cacgcacttc agctataata gccttctcca ctgcaacggc cactccgtct tcctcattcg
    14101 aagcggtcac atagtcggca caggctttca ccgagtcttg tgaatgtccc atagctacgc
    14161 ccagcccggc caattgaatc attgttacgt cacacacacc gtcgcccaca gcaatcactt
    14221 cctcacgctt catatccagc acctccagca aagcgcccaa agagttggct ttgtcgatgg
    14281 cgcagggaac tacttccaga aaatatggct ccgaacggaa tacgtccaac gctccgttca
    14341 gtcgtctctt ccagtgatct tccaaaccaa ccagtgcttc ttcgtcatcg ctcaccagca
    14401 tacacttaca aggagcaaaa tcaacggcag cagaaaattc ttcttcttta attatttgca
    14461 ggttattcaa ccgggcttca ttttggatat gttcattttc aggagaatcc gttataatcg
    14521 tatcatcatg ataagtgaat aaggcaaaac cgtttttacg ggctttcttt tccagatacg
    14581 gcaacatttc gggattaatc cgacgttcaa acagaatttc cccgttttgt gcattgataa
    14641 tctgacagcc attataggaa aggataaaac ctccatagtt tccaagttca agcatcttgg
    14701 ccaacggcat caggccataa gtcggtctgc cggatgccag cacaatacgt actcccattt
    14761 gctgaacctt caacagggca gccaatgtac gcttactaat ttctttcgca tcattgagga
    14821 gtgttccgtc tacatcaaga accaataatt tatacttcat gattacacga ttttgattta
    14881 gattacaaaa ttatatagaa aaatcgagtt tttctacacc ggcacaataa aaaccgaggc
    14941 caaccctcaa actctgcttc
//
