LOCUS       gnlProkkaBBPAHEMI_44   23171 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BBPAHEMI_44.
ACCESSION   gnlProkkaBBPAHEMI_44
VERSION     gnlProkkaBBPAHEMI_44
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 03:23:45
            Original ID  :: gnl|Prokka|BBPAHEMI_44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 23171
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23171
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[7697:13171]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7698..13171
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..23171
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..23171
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(3..653)
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="MKAKTKVRFLNLNILSLTQKELLEQMAEGVLYTPNLDHLIKLQHD
                     REFYDIYQQAEWIVCDSQILYLASKLLKRSLPMAIPGSSFFTAFYNYHANNPNCKIFLL
                     GAAEGVAKKAMENINRRVGRQIVVGAHSPSYGFEKNEQECEELIRIVNESGATVLLVGA
                     GAPKQEKWIAKYRSRMSGVKLFMALGATIDFEAGNIKRAPRIFQILAMEWFYRF"
     CDS             complement(654..1568)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_2"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.8e-27,
                     bitscore: 89.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILSIIIPHKNSSALLERLLMSIPSNDEFEVIVVDDNSKKCEKEN
                     LCKIVSTYKFHLYEMKNNVGAGACRNLALKKAKGEWVLFADSDDYFISNMYEIISEGLK
                     SKADIVYFRTDSIYNDTGKQAYRHENYNQLIDTYLMNKNAENLKFKFLVPWAKLFKRSL
                     ISSCGAVFEEIPAGNDMNFSVLVALSAHSVEIVDKVLYIVTVSRGSITTTFSKEKFDSR
                     FQASVRCNRLLREHGMGKYQQSILYFIVKGYKFGFKYLIHMWVIILKTKSNPFIGFSKL
                     VHYKKVLQDRENPRYLLKSKSRL"
     CDS             complement(1565..2794)
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="MQFSARVNANSQFFMIIILTTVLFLICPLISILVAYWVLLRENKE
                     RCLWLFAVLMACYISFINISKSISSDPDLPWYTEQYLEAGNLSYIQYIMGFGLNGKGRE
                     LFFPTFNYLVYFIAGDNVALYRFIHSLVCYILVFFAIIRFTTYLKIDNRKIVIPLLWYT
                     CFPWIFTYSQTILRQFLACSFLLWICVEYFFYDKKMIIPFACMVLSHTSTILFFPLVYL
                     PFFHKELTRKSIVFYLIGILLFLLIQPIAEFLGMFVADSDTILSYALKRASSDTTFELP
                     PLGLSKILFLMLEIGVLLYYYIQIKVKQIDAGVLKRHIGLINSIIILNLFILINIHQLE
                     LSNRLFTYSAVLSVFPLCYLVQKYRLKENVITLFFVIMQLLLVLYFMNSIYIYEIPFGI
                     LINPFHLLFQ"
     CDS             complement(2799..3638)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_4"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.2e-12,
                     bitscore: 40.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDIAVLLTVFNRCEKTISCLKNLYAQKLPKNVSFDVWLTDDNCT
                     DGTPLAVAKEYPEVHILTGEGILFWNRGMINAWEAAAKYKDYDAYLWLNDDTNLNKGAL
                     ETLVKTADEAGWKKIIVGSCSKIDNPSIITYGGRNAKKHLLRPSLNKAIECSFFNGNIV
                     LIPQFVYKVLGTNDPVFHHSLGDFDYGLRGVKKNIQSLIAPGILGECDRHEALPSWCNP
                     QKTLLQRWNAFHSPLGCNPKEFFIFEFRHYGFLRAYFHYMTIHIRLLFPQLWKTRKI"
     CDS             complement(3984..4895)
                     /locus_tag="ctg43_5"
                     /transl_table=11
                     /translation="MRNWLKKGKTYLDELVCVLKSIALEKDSIVNCDETWCKVRKYDHY
                     KKCYIWVLVNKARKTAIFFYENGSRGRDVLTDFLGDAELKSIMSDGYNAYVFIGNELNS
                     GRFKDTVHQVCMSHAKNKFVKASNQGSEPNAERFSKILKEFFMRERKYDDAGLTSQERL
                     RERQSLEMKELLIELRSLLDSEQSKDSEFRSQYYREALNYLNRFWKEIFAYLDDGELPI
                     DNNLAERTIRKLTTQRNNSLHYGSDAGAEMAATYHSVIGTVKLHGSSIWNFIGTFFKNI
                     FNGCRDYVNMVPDKITLATSQC"
     CDS             complement(5067..5777)
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MIDLQDIIKTKRELLSRETYSRNPINYSAGMAEDQKDRYIQYLAE
                     QNQDLRLTGDAMKLVLEDSMAQMKELKAQMSSMQSKHADLENRLSEEHKLRKSAERKIK
                     SLQEKLDYAHQERFGDRRQKIQSKAKTSDSDRRKEKDDYDGTDDTLRTDSVGHVPSQEL
                     KEPSGKDRDLSNRPDGYKTMGVAGEATEHPSDLTKVPGRIIERRMVRVFSFRTFLTEEC
                     FEMVHYAEPGKRPK"
     CDS             complement(5850..6185)
                     /locus_tag="ctg43_7"
                     /transl_table=11
                     /translation="MLSVTGLNHFYYVRDFTDMRCKHSRVLSIIRERLHREPNDGDVFI
                     VMSRNRRIVRMFSFDNRSYSLFEKKFVAGYQFMKVERNGADTVYRIAWKDVVLILENPI
                     VKTLKIR"
     CDS             complement(6179..6541)
                     /locus_tag="ctg43_8"
                     /transl_table=11
                     /translation="MYSSEDLERFYFQYQTEALPHGESLQSFCVKNKVPYNIFQKWYRD
                     TRKKVVEVQVDGAPVIGHEEQSSAIDQPQPVSPGRTDHPVRIWVEIRISNGLHLSQKNL
                     SYQDLVRMVEKLEGLC"
     CDS             complement(6584..6856)
                     /locus_tag="ctg43_9"
                     /transl_table=11
                     /translation="MSNQVPYNLFSKWYKDTRKKIIPVLVLGAPSTESEMPESPSPLPE
                     QKSESDPRLFCHTELRILVDIRMSNGVHISQKNLSNEGKQSKIGS"
     CDS             complement(7046..7711)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 117.9; E-value: 8e-36)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_10"
                     /transl_table=11
                     /translation="MMSDKQTIKAVLFDLDGTLLNTSEGIACSVLHTLSVMQLPSISSD
                     EVSTFIGPPIQESLKRHFRLSDEDVQKGADIFRAYYKDCALFKAALYPGIIDLLKQLKQ
                     KGFLIGVATYKREDYAMDILKHFGILEYCDVVHGADNDNKLRKSDIVYLCISEMSVDNS
                     EVVLVGDTYHDLEGAEEADIHFIAVTYGFGFRESVRELSSKNVVGVADNPMEIEGLLK"
     CDS             complement(7698..9302)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 58.9; E-value:
                     7.9e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_11"
                     /sec_met_domain="HMGL-like (E-value: 4.1e-21, bitscore:
                     69.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKVLMLDCTLRDGGYVNDWDFGHSTITGIYKRLEAAGADYIEV
                     GFLDDRREFDINRSIMPSTEAINKIFGSVKKGKAIPVAMIDFGTCSLDSIGSCDSTFID
                     GIRVIFKKEKIDQALPFCKAIKEKGYKLFIQAISITAYSDIEMLEYVNRINEIKPYAFS
                     IVDTYGLLDNSSMARYFYLIDNNLDPSIKMGYHEHNNFQLGFSNTIKFLEKSTKRTLVA
                     DSTVYGMGKSAGNCASELLAMHLNEYYGGHYDLNQLLEIVDTDLMPIYQKHYWGYKYDF
                     YIASMQRCHPSYVQYLLKKSTLSVSSINEILSSIPEEIKLLYNKQWIEQAYLDYQNRAK
                     DDTEALQQLKVELEAASDKPVLIIGPGNTVKEQKKGVELFISGNDPVVFSVNFYTKLYS
                     IDYTFISNAKRYAKFVDIQHGDSIGSKLILTSNVTACDYMPNYVLNYESLLNKESENPD
                     NALVLLLKALIRIGITEVYLAGFDGFTNTPNDYYDRDYELSSTKDESYNDLLSDDLSKI
                     NQSIRLHFITESLYDVR"
     CDS             complement(9306..10043)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_12"
                     /sec_met_domain="NTP_transf_3 (E-value: 9e-13, bitscore:
                     42.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKIIAIIPARYQSSRFPGKPLADIFGRPMIWWVYNQVIKVKEFL
                     EVYVATDDQRIADVCSNYGMKFIMTQSNHPTHVHRIHEVSDNIAADYYVVVCGDEPLIS
                     PDIIEAVFPSQDVDNSHMYVGGLCRYFTEPAEVIDPANIKIVTNDSDECVLLSRAPIPF
                     PYKTVLFKYKKVVGVECYNKQALDFFVSTPKGYLENIEDVTLQRFLENKIHIKYKLVDS
                     VSLSVDTPRDLEKVKEIMVTKQA"
     CDS             complement(10106..10612)
                     /locus_tag="ctg43_13"
                     /transl_table=11
                     /translation="MLIKVIGGTTHRREEYYASSQCSGSEFFRHLGEVTDTDLFVYCPC
                     TSPFIKPETVSQCINQFISTSDYDCLATVSSVKEFLWLDGDPMNYDPAHAPNSQDLPDV
                     VALNFGVTVVRKEDLIKNSNIIGKNPQFVKTSDIESIDIDTPLDFYIAEQLYKKLVIEK
                     KRLLE"
     CDS             complement(10572..10784)
                     /locus_tag="ctg43_14"
                     /transl_table=11
                     /translation="MKITAVIPIRSGSQRVKDKNLRAFADTNLMELKIKNLLQVPELTS
                     IVVNTNSELAIEIVNKSYRGDYSPS"
     CDS             complement(10796..11413)
                     /locus_tag="ctg43_15"
                     /transl_table=11
                     /translation="MKILSLIRTLKSVLYAYDSDQWEKRVGALGKDSYLRGPISCANPS
                     LIFVGNHSHIFGQANYIIRNGKFIVGDYTGIAQGLTVITGNHISEKGKLFNDCLQLDEQ
                     DVIIEDDVRIGAFVTILPGVKIRRGAIIGAGTVLRFSIPPYAVVTGNPAKIVGFRMNPQ
                     EALEHEAALYPEEKRLSADELFDNYEKYYFNRMSEIIEYLKV"
     CDS             complement(11410..11655)
                     /NRPS_PKS="Domain: PP-binding (11-76). E-value: 9.5e-10.
                     Score: 30.8. Matches aSDomain:
                     nrpspksdomains_ctg43_16_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_16"
                     /sec_met_domain="PP-binding (E-value: 2.7e-09, bitscore:
                     30.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERHDIYTSLNQILGKIIGDTKLDLNELTTTDEISGWSSLVQTQL
                     VVEIEKHFNCRLTLRDIMKIDKNISSIVTLIDNKLQ"
     aSDomain        complement(11428..11622)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_16_PP-binding.1"
                     /evalue="9.50E-10"
                     /label="ctg43_16_PP-binding.1"
                     /locus_tag="ctg43_16"
                     /protein_end="76"
                     /protein_start="11"
                     /score="30.8"
                     /tool="antismash"
                     /translation="QILGKIIGDTKLDLNELTTTDEISGWSSLVQTQLVVEIEKHFNCR
                     LTLRDIMKIDKNISSIVTLI"
     CDS             complement(11660..13171)
                     /NRPS_PKS="Domain: AMP-binding (16-408). E-value: 9.2e-71.
                     Score: 230.4. Matches aSDomain:
                     nrpspksdomains_ctg43_17_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     210.7; E-value: 5.1e-64)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_17"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-73, bitscore:
                     241.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKIDVLERLSTKMAKYLDQNCFCIKDKYYTYRELSILTAKIQ
                     QEIRNQYTETTPVGLVNNDDIYTYASILALWYEGLAYVPLHPLQPIARCIDIIEQVNIQ
                     LIIDSTEMSRYVDKYNVLYPQNNSNTDVVFPVINNIDDEALCYILFTSGSTGKPKGVQL
                     NRRNITSFVAAFENAGIVLSHEDRCLQCFDLTFDVSVQSYLMPLLNGACVYTLPLDCMK
                     YACSADLIERYKLTFGAMAPSMVRFLKPYFDELDMSSLKKCILTAEASNLSLVKDWKKC
                     AYNAELYDFYGPTEATIYCTYYKLPDDINQTKNRNDILFIGKPMSGIKAVLISPDGIVL
                     NKGIGELCVAGEQVTPGYWQLFEKNKEAFLTISIDNKDYRFYKTGDLCQFDKDGDLEYI
                     GRIDFQAKVQGYRVELGEIECKIREFTKCDTVVLAIKEDNNDDILVGFVESRLVDEKQV
                     YVYLREQLPPYMIPKSIISLAQFPLNNNGKIDRKQLIEIFKTHNK"
     CDS_motif       complement(11915..11980)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_17_0003"
                     /evalue="3.40E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg43_17"
                     /protein_end="419"
                     /protein_start="397"
                     /score="32.0"
                     /tool="antismash"
                     /translation="YIGRIDFQAKVQGYRVELGEIE"
     aSDomain        complement(11948..13123)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_17_AMP-binding.1"
                     /evalue="9.20E-71"
                     /label="ctg43_17_AMP-binding.1"
                     /locus_tag="ctg43_17"
                     /protein_end="408"
                     /protein_start="16"
                     /score="230.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AKYLDQNCFCIKDKYYTYRELSILTAKIQQEIRNQYTETTPVGLV
                     NNDDIYTYASILALWYEGLAYVPLHPLQPIARCIDIIEQVNIQLIIDSTEMSRYVDKYN
                     VLYPQNNSNTDVVFPVINNIDDEALCYILFTSGSTGKPKGVQLNRRNITSFVAAFENAG
                     IVLSHEDRCLQCFDLTFDVSVQSYLMPLLNGACVYTLPLDCMKYACSADLIERYKLTFG
                     AMAPSMVRFLKPYFDELDMSSLKKCILTAEASNLSLVKDWKKCAYNAELYDFYGPTEAT
                     IYCTYYKLPDDINQTKNRNDILFIGKPMSGIKAVLISPDGIVLNKGIGELCVAGEQVTP
                     GYWQLFEKNKEAFLTISIDNKDYRFYKTGDLCQFDKDGDLEYIGRIDFQAKV"
     CDS_motif       complement(12065..12142)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_17_0002"
                     /evalue="1.50E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg43_17"
                     /protein_end="369"
                     /protein_start="343"
                     /score="23.8"
                     /tool="antismash"
                     /translation="IGELCVAGEQVTPGYWQLFEKNKEAF"
     CDS_motif       complement(12683..12736)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_17_0001"
                     /evalue="1.80E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg43_17"
                     /protein_end="163"
                     /protein_start="145"
                     /score="26.6"
                     /tool="antismash"
                     /translation="CYILFTSGSTGKPKGVQL"
     CDS             complement(13182..14033)
                     /locus_tag="ctg43_18"
                     /transl_table=11
                     /translation="MITLRGLFRDLKFLIGCFVYLVKHYSLFSGLKFQGRQERIVYLLC
                     NGPSLKNDMETIKKLKGVDFIVVNFMANDSLFWEIKPQYYTLMDPLFFTNRRENRYMER
                     LEVLFDSFNRIDWEMIIFLPIQYEKSFREFSKINNPKIKIMVLNTFSSYVASDNVRHFC
                     YRKGYAMPNAQTVAIESIFAMLNMGYSTIYLYGVDHTFLEGLKVNDKNELVHVYQHFYE
                     NEPKIIPVTDAFGYHNSLTKELQTIVNIFASHEQCRKYADHLGANIYNLTKGSQIDSYE
                     RR"
     CDS             complement(14030..15475)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_19"
                     /sec_met_domain="Polysacc_synt (E-value: 1.4e-21, bitscore:
                     70.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRAKQLGKNTLLVFIGSFGAKIISFIMLPFYTRWLSVTDYGVVD
                     MISIYQSLLTDFLTAAISTSIFIFPKGVAFHRQKEYFSSGLIFAFFAFIVAALLFYIVR
                     SSFNLFSVSNSFTDYTVWIYIMIFITFIQTYLQQFCRSIDKMYVFTLIGILLTLCTGIF
                     SFIFIPKNGVYGYLIAMVLSNVVVAITTFFIAKLYKYVSLKSFNKVSLKEMLKYSIPTI
                     PNVLMWWVLGSLNRPILEGTVGLSGIGILAVAQRFPNAASLVFSIFGNSWQISVLEEYK
                     MNDFPLFFNRVLAIFSIITCLGVLILSYISDWLVTFIVGNNFLSSSTYIPCLSLALFFL
                     CMNTIISPIFSAVRKSKYYLYSSIWSAVLTIGLNILLIPLIGIMGACISIVCSHALMTL
                     LRVKYTLIFVSVYLKEQYLFLGLLAVAFIVALSIGDSLMFRTMALLVAFLGVALVIRNF
                     DKRLNIKFLAIKLFKNKIKFKQS"
     CDS             complement(15477..16487)
                     /locus_tag="ctg43_20"
                     /transl_table=11
                     /translation="MHLLICNSNMFIPIVLTTVLNNSDQRYLIYVDIPSIYMFFDKLNL
                     PENCNLLKYPHYINWKNANKAKQFIWNQLEHIDIKSITFYHTAYGELATWLISKYSRNT
                     TIYFQSPFPSFCFKKRISLKALKLFLVYKIIYNTDIIPMDSGNNTLPSISPKFFKKNNV
                     INKNAMVDNDLVCNYVNEKLNLNNNNRSILLVTGSNITAGFCDETDYGKIINSILSALG
                     KDKFMVKCHPRFDDLLSIEKMLPAIPKYIPGNVILPLFDCYIGLCSALLIEAANVGKCS
                     ISILNLLNIDFKLKSVLKNSLEVRLKSGSTIYYPNSISELNDIVKRSCNNNITMI"
     CDS             complement(16825..17760)
                     /locus_tag="ctg43_21"
                     /transl_table=11
                     /translation="MIWIIGTGTIALEYAKILDQLEHEFIAVGRSGKNADEFIEAGAKE
                     VVSGGLNNYLAASPTTPQKVIVATNVDQLAEVTVSLLNFGIKDILVEKPGFCRPEEITP
                     VVQLAQAKNAHVLLAYNRRFYSSVLAAEKIIKEDGGITSFNFEFTEWGHVIETLDYSHN
                     IFDNWFFANSSHVVDLAFFLGGEPQEISCFSAGELSWHKPAVFSGAGITNKGALFSYQA
                     NWNAPGRWVVEVLTTKHRLYFKPMETLQIQEKGSVAIKPVEIDNQLDIDFKPGFYLQTK
                     AFVEGDYGRFCTVEKQMKHINTIYKKIVEK"
     CDS             complement(17781..18734)
                     /locus_tag="ctg43_22"
                     /transl_table=11
                     /translation="MYKIAVIGAGQLGSRHLQGLKLSKLKSDIWVVDNNPNSLQIAQQR
                     YEEGEVNSNQTIYYIQLIDQLPAELDLVVIATSSKPRLTILKSLLAKVKVVNIILEKFL
                     FTGLADYDEAAQLLQINHVNAWVNCPRRLFGFYAEIDSMIDKQKPLVMEYADSNWGLCC
                     NSIHMIDIFMMLSGEKAYIADFSGIIPQVKDSRRNGYIEFDGIVNVSTPNGSTLRLTCV
                     DDDTVQHQMTIINGSHHIIINEPEGFMSVDGNKQPVHIKYQSQLTGVVADEILLNGNCK
                     LTTYAESSNYHKVFLKGILGVYNKVTGDMHDRCPIT"
     CDS             complement(18754..19794)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 144; E-value:
                     8.7e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_23"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-11, bitscore:
                     38.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCSHIILQSFSIIDAIRCINEIHNEPLVLFVVDENKRMQGTLTD
                     GDVRRALIKGIDVDAPISEAMHRNFNFLRRGVNDRVEDIHHQRDLRMRLVPILDEENHI
                     CEIINLEHYVTKLPIDAVLMAGGKGERLRPLTEKTPKPLIKVGDKCIIDYNIDRLLSYG
                     LNHISVTVNYLGDQIEEHFREERDGVKIVTVREPKYLGTIGSIKFVETFYNDTVLVMNS
                     DLFTNIDFEDFFLHFCQHDTDMSVAAVPYVVKVPYGVFNLKGREIKGVTEKPTISYYAN
                     AGIYLIKRKLLDLIPDDIFFNATDFMDKLIEQGYKVIRYPISGYWLDIGQHDELARARE
                     MVKHLK"
     CDS             complement(19800..20495)
                     /locus_tag="ctg43_24"
                     /transl_table=11
                     /translation="MNILVIIPARGGSKGIPHKNVKELNGKPLICYSIDAARQLTTDEN
                     ICVSTDDDVIIKVVEDYGLKVHFKRPAELATDCAGTNGVLLHALEFYEKQGRKYDVVVL
                     LQPTSPFRETKSLKEAVALYTSDIDMVVSVKEAATNPYYNSFEEDAEGLLVISKGDGTI
                     ERRQDAPKVWEFNGSIYVINSTRLKEVGLSKLNRIRKYVMDDLHSIDIDSMFDWYMAEK
                     VISSHLIEN"
     CDS             complement(20511..21515)
                     /locus_tag="ctg43_25"
                     /transl_table=11
                     /translation="MINHVYIIAEAGVNHNGRLDLALQLCNAAKDAGADAVKFQTWKTE
                     KIVTRNVELAVYQENNISDKTKSQFKMLKELELSYDNFEVVKNHCDEIGIQFLSTPDEI
                     DSLDFLCNFNLPFIKLGSGDVTNIPFLRLVGSRHIDVVLSTGMSYLGDVEIAYRTLIEA
                     GAKSVSLLHCTTNYPCPMHEVNLRAIQTLKDAFHCSVGYSDHTMGVEVPVAAVAMGAEI
                     IEKHFTLDKEMDGPDHKASLNPEELKQMVVAIRHIEQALGDGIKQPNESEKQISEVVLK
                     RIVAATPIKEGEVLSADNMTVKRSTVGLKASLWDLVNGRIATCNYAIDEPIII"
     CDS             complement(21508..22500)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_26"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.4e-16, bitscore:
                     53.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNILCCNAGRRGRLMIDMRKTIGDSGNVVATDNWSVAPAIFFAN
                     KQYVVPKITHPNYIQEVLGICKKEDIKAIFTLIDPEIDLLASNKKKFEEIGVLPLCPSK
                     QTADLCFDKYSMYLYLKNHGVNTPLTFHELDDFKAAYFKGEIQFPVFIKPRTGSGSVGA
                     HKVNTMQDLENYYAENAFDYIIQEFMQGDCDADAYIDYYSKEVVSIFSKKKIETRIGGA
                     SKTISFKDQRLFDFVQSFMHLFDFAGAIDMDFFFRDGEYYLSEINPRFGGAYLHAYGAG
                     VDFFKLIINNINGVTNEVRIGDYDEGVLMLMYDDVVITKEVDLLRDYHD"
ORIGIN
        1 agaaagcgat agaaccattc catcgccaag atttggaata ttctgggagc acgttttata
       61 ttacctgctt cgaagtctat ggtagcgcca agagccataa ataattttac accggacatc
      121 cgactacggt attttgctat ccacttttct tgcttgggtg caccagctcc aaccaacaac
      181 acagtagcgc cactttcatt gacaattcgt atcagttctt cacactcctg ttcgttcttc
      241 tcgaaaccgt aagagggtga atgagcgccg accactattt gcctccctac tctcctgttt
      301 atattctcca tcgccttttt agcaactcct tcggctgctc ctaacagaaa aattttacaa
      361 ttgggattat tggcatgata gttatagaat gccgtaaaga aactgcttcc cggaatagcc
      421 atcggtaagg atcgctttaa tagttttgat gcaagataaa ggatctggct atcgcatact
      481 atccattccg cttgctggta gatgtcgtaa aattccctgt cgtgctggag ctttattagg
      541 tgatcgaggt taggggtata gagtacacct tcggccattt gttctaacag ctctttttgg
      601 gtgagagaga gtatattaag atttaggaag cgaactttag ttttagcttt catttacaat
      661 ctggattttg attttaaaag atatcgagga ttttctctgt cctgaagaac tttcttataa
      721 tgaactaatt tactaaaacc aataaaagga ttagattttg ttttcaatat tatcacccac
      781 atatggatta aatatttaaa accaaatttg tatcccttca caataaaata caatatagat
      841 tgctgatact ttcccattcc atgctctcgc aacaatctat tacatctaac agatgcctga
      901 aaacgtgaat caaatttttc tttactgaat gttgtagtaa tagagccacg agaaactgta
      961 actatataca aaaccttatc aacaatttcc accgaatgtg ctgaaagagc tacaagaaca
     1021 gaaaaattca tatcattacc tgcaggaatt tcctcaaaaa cagctccaca agaagaaatc
     1081 aaacttcgtt taaataattt agcccaagga accaaaaatt taaatttcag attctcagca
     1141 tttttattca ttagataagt atctatcagt tgattataat tctcatgacg ataagcttgt
     1201 ttgcccgtat cattataaat actatcagtt ctaaagtaca caatatcagc ttttgattta
     1261 agcccttcgc ttattatttc gtacatattg gatataaaat aatcatccga atcagcaaaa
     1321 aggacccatt ctccttttgc tttttttaga gccaaatttc tacaagcacc agcacctaca
     1381 ttatttttca tttcatacaa atgaaattta tatgtagata ctattttaca caaattttct
     1441 ttttcacatt ttttactatt atcatctacg actatcactt caaattcatc atttgaagga
     1501 atagacatta ataaccgctc taataaagca gacgaattct tatggggaat aataatagaa
     1561 agaatcattg aaataataaa tgaaaaggat taattaatat accaaaaggt atttcgtaaa
     1621 tataaattga gttcataaaa tacaacacaa gcaacagttg cataataaca aaaaagagcg
     1681 taattacatt ttcctttaac ctatatttct gtactaaata gcataatgga aaaacagaaa
     1741 gaacagcaga ataagtaaac aaacgattac taagctctaa ttgatgaata tttattagaa
     1801 taaatagatt caaaatgata atactattta ttaaacctat atgtcgcttt aatacaccag
     1861 catcaatttg ttttacttta atctgaatat aatagtacag tagcactcct atttctaaca
     1921 ttaaaaataa tattttagat aagcctaaag gaggcaattc aaaagtcgta tcacttgatg
     1981 cgcgctttaa agcatatgat aaaatagtat cactatcagc tacaaacata cctaaaaatt
     2041 cagctattgg ttgaatcaac aagaatagta aaattcctat caagtaaaag acgatagatt
     2101 tacgagttaa ttccttatga aaaaaaggca agtaaacaag agggaaaaat aaaatagttg
     2161 aagtatgaga taataccata caagcaaatg gtattatcat ctttttatca taaaagaaat
     2221 attcaacaca aatccataat aaaaaggaac aagcaaggaa ttgtcgtaaa atggtttgtg
     2281 agtaagtaaa aatccacgga aaacaagtgt accataacaa gggaatcact atctttcgat
     2341 tatcgatttt taaataagtg gtaaaacgga ttatagcaaa gaataccaat atatagcaaa
     2401 ccaaagaatg tataaatcta tatagcgcaa cattatctcc tgctataaaa tagaccaaat
     2461 aattaaaagt aggaaaaaac aactcgcggc cttttccatt taatccaaac cccataatat
     2521 actgaatata agacaaattt cctgcttcaa gatactgttc tgtataccat ggaagatcag
     2581 ggtcagaaga tatagattta gatatattaa taaaagaaat ataacatgcc atcaaaacag
     2641 cgaacagcca aagacacctt tctttatttt ctcttaacag aacccaataa gcaactaata
     2701 tacttatcaa aggacaaatt agaaataaga cagtcgtcaa tataattatc ataaaaaatt
     2761 gactattagc atttactctt gccgaaaact gcatattatt atatttttct agttttccat
     2821 aattgaggaa acaataacct tatatgaata gtcatataat gaaagtatgc tctcaagaat
     2881 ccataatgac gaaattcaaa aataaagaat tctttagggt tacatcctaa aggagaatga
     2941 aatgcattcc atctttgtaa taatgtcttt tgaggattac accatgaagg aagtgcttca
     3001 tgcctatcac attcacctaa tatgcctgga gctattaaag attgaatatt tttcttcact
     3061 cccctcaagc cataatcaaa atcacctaaa gaatgatgaa agacagggtc attggtgcct
     3121 aaaactttat acacaaattg cggtattaat actatattgc cattaaaaaa tgaacattca
     3181 attgctttat ttaaactagg tctaagcaaa tgcttctttg cattcctacc accataagtt
     3241 ataattgaag gattatctat tttagaacaa gaaccaacta taattttctt ccatccggct
     3301 tcatcagctg ttttaaccaa cgtttctaat gctcccttat taagattcgt atcatcattt
     3361 aaccataaat aagcatcata atctttatac ttagctgcag cttcccatgc atttatcatt
     3421 cccctattcc aaaaaaggat accttcacct gttaaaatat gtacttcagg atattctttt
     3481 gcaacagcca aaggagtgcc atcagtgcaa ttgtcatcag ttagccatac atcaaaagaa
     3541 acatttttag ggagtttttg tgcatacagg tttttcaaac aactgattgt tttctcacac
     3601 ctattaaata cagttaataa cacagctata tctttcattt tatgtatttt tatttattca
     3661 atctggtcac actcaacata aaaccttcaa cttctacacg agcagtttca aaccggcgtg
     3721 gctcaaatta cactgctgta tgtgaacgcc attgcttata tagatattca ccattattcg
     3781 taccgttttt tgactggaag caggttggaa gtactgagta attgtccgaa atttggatca
     3841 ccaagctttt actacctgag ttacaggtag taaagagata gaactaacct tcgttgcgta
     3901 agcactcaat ttagggcatc ccccttcgaa agggcacttt tcagtgccct aaactgagtt
     3961 ttgttaaaaa attagttttg aatttaacat tggcttgtag ccaaagtgat tttgtcagga
     4021 accatgttaa cataatccct gcacccgtta aagatatttt tgaaaaaagt tccgatgaaa
     4081 ttccagatag aactgccatg aagctttacc gttccaatca cactgtgata ggttgccgcc
     4141 atctcagcac cggcatcact accataatga agtgaattgt tgcgttgagt ggtcagcttt
     4201 cgaatagttc gctcagccag attgttgtct atcggtaatt caccatcatc caagtaagca
     4261 aagatctctt tccagaaccg gttcagataa ttgagagctt ctctataata ctggcttcta
     4321 aattctgaat cctttgactg ttcactatcc aacaggctgc gcagctctat cagcagctcc
     4381 ttcatttcca gactttgcct ttcccgcaac cgttcttggg aagttaatcc ggcatcatcg
     4441 tatttacgct ccctcataaa gaactccttt aaaattttgg aaaagcgttc tgcattcggt
     4501 tcactaccct gattggaagc cttgacaaac ttgttcttgg catgtgacat acaaacctgg
     4561 tgtacagtat ctttaaaccg gcctgagttc agctcattgc cgataaatac ataagcattg
     4621 tatccgtcgg acattatact cttcaattct gcatcgccca aaaagtctgt aagtacatca
     4681 cgaccacgcg agccattctc atagaagaaa atggctgttt tccgggcctt gttgaccaga
     4741 acccaaatgt agcacttctt atagtgatcg tatttgcgca ctttacacca ggtctcgtcg
     4801 cagttcacta tcgaatcttt ttccaaagct atagacttca atacacagac cagttcgtcc
     4861 aggtatgtct tacctttctt aagccagttg cgcaacgtgt ttttagaaat ggtcatgccc
     4921 gtatctgtca gccattggtg aagaagacca aaagtcacat tctttacata aacttcgtag
     4981 gcgatagcct gcagaaattc aggagcagcc ttagtacctt caaaactggt tactacatcc
     5041 ggatggcctt cagaagggaa atagccctac ttcggccttt taccaggctc tgcataatga
     5101 accatctcaa aacattcttc cgtaaggaaa gtacggaaac tgaacacccg taccattctc
     5161 ctttcaatga tccgaccggg aacctttgtc aaatcagaag gatgctctgt cgcctctccg
     5221 gctaccccca tcgttttata accgtcaggg cgattggaca agtcacggtc tttcccggaa
     5281 ggctctttta actcttggga tggaacatga ccaaccgaat ccgtgcgaag cgtatcatcg
     5341 gttccatcat aatcatcctt ctccttccgg cggtctgaat cacttgtttt agctttagat
     5401 tgtatctttt gacgtctatc accaaaacgt tcctgatggg cataatcaag tttttcttga
     5461 agtgatttta tcttacgttc agccgatttg cgaagtttat gctcttctga caaccgattc
     5521 tcaaggtcag catgtttcga ttgcatggat gacatctgag ccttcagttc tttcatctga
     5581 gccatagaat cctctaaaac aagcttcatg gcatcacctg tcaacctgag atcctgattt
     5641 tgctcagcaa ggtattgtat gtatcggtct ttctgatcct ctgccatacc tgcgctataa
     5701 tttatagggt tgcgtgagta ggtttcccta ctcaacaact ctcgttttgt tttaattata
     5761 tcttgcagat cgatcatact taaacctttg agttacagca ttaaaggtaa taaaataatc
     5821 gcaaagccgc aagtggataa atagattgat tatctgattt ttaatgtttt aactatagga
     5881 ttctcaagaa tcaaaaccac gtccttccag gcaatccgat aaacagtatc tgccccgttc
     5941 cgctccactt tcatgaactg atagcctgct acaaacttct tttcgaacag actatatgaa
     6001 cgattatcaa atgaaaacat acggactatt ctgcgattgc gagacatgac tataaagacg
     6061 tctccatcat tgggctcacg gtgaagccgt tcacgaatga tagacagcac acggctgtgc
     6121 ttacaacgca tatcggtgaa atcacggaca taataaaaat gattcagacc ggtaacactc
     6181 agcataaccc ctccagtttc tctaccatac gaaccaaatc ctgatagctt aaattctttt
     6241 gggacaaatg caagccattg ctgatacgaa tctcaaccca aatacgaaca gggtgatcag
     6301 ttctgcctgg tgataccggt tgaggttgat caatggcact ggattgttcc tcatgaccga
     6361 ttacaggagc accatcaacc tggacttcaa ctactttttt ccgggtatcc ctgtaccatt
     6421 tctgaaagat gttataagga actttgttct taacacaaaa cgattggaga gattctccat
     6481 gaggcaaagc ctcggtctgg tactgaaagt aaaacctttc aagatcttca ctgctataca
     6541 taaattctaa aatttttgtt cgcagcgaag atagaggttt aaattatgag ccaatttttg
     6601 actgcttacc ttcgttgctt aaatttttct gactgatatg aacaccattg ctcatgcgga
     6661 tatccaccag gattcgaagt tcggtatgac aaaaaagccg aggatccgat tctgactttt
     6721 gttccgggag tggcgaagga ctttccggca tttccgattc cgttgaggga gcacccaaaa
     6781 ccagaacggg aattatcttc ttccgggtat ccttgtacca tttggaaaat aggttataag
     6841 gaacttggtt ggacatacaa aatttttatg tagaaacacc agcaggaatc ccttccaatt
     6901 tatagcgcaa aaatagacgc tcaaaatcat tgtaactata cataaacttg gattttgatt
     6961 taacgaaagc aaaggtctga cttttttatc ggttatccta tacgtcattt ttggacgcta
     7021 acgagataga attctattat gaaattcact tcagcagccc ctctatttcc attggattat
     7081 cagctactcc caccacgttt ttactagaaa gttctcttac actttctcta aaaccaaaac
     7141 cgtaagttac agcaataaaa tgaatatcag cctcttctgc tccttccaaa tcatgatatg
     7201 tatcacctac taaaaccact tcgctattat ccactgacat ttcagatata caaagataaa
     7261 caatatcact cttacggagt ttattatcat tgtctgcacc atgaacgaca tcacaatatt
     7321 ctaaaatacc aaaatgcttt agaatatcca tagcataatc ttcacgctta tatgtagcta
     7381 ctccaataag aaaccctttt tgcttcaact gtttcaacaa gtcaatgata cctggatata
     7441 aagctgcttt aaacaaagca cagtctttat aataggcacg aaatatatcc gccccctttt
     7501 gaacatcttc atctgataat ctaaaatgac gttttaaaga ttcttgaata ggggggccta
     7561 taaatgttga tacctcgtca gaggatatag aggggagttg cattacagac agcgtgtgca
     7621 agacactaca tgctattcct tcacttgtat tcaaaagagt cccatccaaa tcaaacagga
     7681 ccgctttaat agtttgctta tctgacatca tacaaacttt ctgtaatgaa atgaagacgg
     7741 attgactgat ttattttaga taaatcatct gacaaaagat cattataact ttcatcttta
     7801 gttgatgaaa gttcgtaatc gcgatcataa taatcattag gtgtattggt aaatccatca
     7861 aaacctgcaa gatatacttc tgtgattcca attcttatta aagccttaag cagcaaaaca
     7921 agagcattat caggattttc agattcttta ttcaacagtg actcataatt gagaacataa
     7981 ttaggcatat agtcacatgc ggtaacatta gatgtaagaa tcagtttaga gccaatactg
     8041 tcaccgtgct gaatatccac aaacttagcg taacgcttgg cattacttat aaaagtataa
     8101 tcaatagaat aaagttttgt atagaaattt acagaaaaga caactggatc attccccgaa
     8161 atgaataact ccaccccttt tttttgctcc ttgacagtat tgcccggacc aattatcaat
     8221 acaggtttgt cactcgctgc ttcaagttca actttcaatt gctgtaaagc ctcagtatcg
     8281 tccttcgctc tattctgata atcgagatat gcttgctcta tccattgttt gttataaagc
     8341 aactttattt cttcaggtat tgaggaaaga atttcattaa ttgagctgac agacaatgta
     8401 ctctttttga gaagatactg gacataggac ggatgacatc gttgcatcga agcaatgtag
     8461 aaatcatatt tgtagcccca ataatgtttc tgataaatcg gcatcaaatc tgtatcaaca
     8521 atctccaaca actggtttaa atcgtaatgc cctccgtaat attcgtttaa atgcatcgct
     8581 aaaagttcgc tggcacaatt tccggcactt tttcccatgc cataaaccgt agaatctgcc
     8641 accagtgttc ttttggtact tttctccaaa aatttaattg tattgctaaa gcccaattgg
     8701 aagttattgt gctcatgata ccccatttta atactagggt ccaaattgtt gtctatcaag
     8761 tagaaatatc gagccatact gctattatca agcaaaccat aagtgtctac aatagaaaaa
     8821 gcataaggtt taatttcatt gatgcgattt acatactcaa gcatttcaat gtcactatag
     8881 gctgtaattg aaatggcttg tatgaagagc ttatagcctt tttccttaat agctttacag
     8941 aatggcaaag cttgatctat tttttctttc ttgaagataa ctcgaatacc atcaataaaa
     9001 gtagaatcac aagaacctat actatcaaga gaacaagtgc caaagtcaat cattgctaca
     9061 ggtatcgctt ttcctttttt tacagaacca aagattttat tgatagcttc tgtacttggc
     9121 atgatggaac gatttatatc aaattctctt ctgtcatcca agaaacccac ttcaatataa
     9181 tcagcacctg ctgcttccaa tcgcttataa atacccgtaa tagtactatg accaaaatcc
     9241 caatcattga catagccacc atcacgtagc gtacaatcta acattaatac ttttttttcc
     9301 atagttcaag cttgttttgt caccattatt tcttttacct tctccaagtc tcgaggggta
     9361 tcaacagaaa gagatactga atccaccaat ttatatttga tgtgaatctt attctccaaa
     9421 aatcgctgaa gtgttacatc ctcgatattc tccagatagc ctttaggtgt ggagacaaaa
     9481 aaatctaaag cttgtttatt atagcattcc acacccacca cttttttata tttaaaaagc
     9541 acagtcttat aaggaaacgg aataggtgct cttgataaca atacacattc atctgaatca
     9601 ttagtcacaa tcttaatatt tgcgggatca ataacttctg ctggttctgt gaagtatcga
     9661 cagagaccac caacatacat atggctatta tcaacatctt gcgaaggaaa aacagcctct
     9721 attatatccg ggctaatcaa aggttcatca ccgcaaacta caacataata gtcagctgca
     9781 atattatcac ttacctcatg aatcctatgc acatgagttg gatgatttga ctgggtcatg
     9841 ataaacttca taccataatt cgagcacaca tcagcaattc gttgatcgtc tgtggctaca
     9901 taaacctcta agaattcttt tactttaatt acctgattgt aaacccacca aatcattggt
     9961 cttccaaaaa tatcagccaa tggctttcca ggaaagcgtg atgattggta tcgcgcagga
    10021 ataatagcta taatcttatc cataaatata atgagttatt ctttatatct gcatcattca
    10081 gcgaaatacc aatcaatccc aaaacttatt ccagcagcct cttcttttct ataactaact
    10141 ttttataaag ctgctcagca atatagaaat caagaggagt atcaatatca atggactcaa
    10201 tatcgcttgt cttgacgaat tgaggatttt taccgatgat attggagttt ttgataagat
    10261 cttctttcct gactactgtt acaccaaaat tcaacgccac cacatcaggg agatcctggg
    10321 agttaggtgc atgagcaggg tcataattca tcggatcacc atcaagccaa agaaattctt
    10381 taacagacga aacagtagcc aagcaatcgt aatccgaagt agaaataaat tgattaatac
    10441 actgagatac agtttctggt ttaatgaagg gcgaagtaca ggggcaatag acaaaaagat
    10501 cggtatctgt cacttcacct aaatgtctaa aaaattcact tccgctacat tgtgaagagg
    10561 cgtaatactc ttcacgacgg tgagtagtcc ccccgataac ttttattaac aatttctatt
    10621 gctaactccg aattagtgtt tacaacaata gatgtaagtt caggaacttg cagaagattt
    10681 ttaattttca gttccatcaa attagtatcc gcaaaggcac gcaagttttt atccttgaca
    10741 cgttgtgatc cactgcgaat aggaataacg gcagtaattt tcattatttt gtattttata
    10801 cttttagata ttctattatc tcactcattc gattaaagta atacttttca taattatcaa
    10861 ataattcatc tgcggacaag cgtttttctt ccggataaag agccgcttca tgttcaagcg
    10921 cttcttgcgg attcattctg aatcccacaa ttttagcagg attacctgta acaacagcat
    10981 aaggaggaat agaaaaacgc aatactgttc cggcacctat tatagcacct ctcctaattt
    11041 tcactccagg caaaatagtc acaaaagcac cgatgcgaac atcatcctca ataataacat
    11101 cttgctcatc cagttgcaaa caatcattaa acagttttcc tttctctgaa atatgattac
    11161 ctgtaataac agtcaatcct tgtgctatcc ctgtataatc accaactatg aatttcccat
    11221 ttctgatgat atagttagct tgtccaaata tatgagagtg attgcctaca aatattaaac
    11281 taggattagc acaagatata ggtcctctaa gataactatc ttttcctaaa gcccctacgc
    11341 gtttttccca ttggtcagaa tcataagcat ataacaccga cttaagagtt cgaatcaaac
    11401 taaggatttt cattgcaact tattatctat caatgttaca atggaagata tattcttatc
    11461 tattttcata atatccctta gagtcagacg gcaattgaaa tgcttttcaa tttcaacgac
    11521 caactgagtt tgtacgagtg aactccaacc agaaatttca tctgtagtag tcaactcatt
    11581 tagatccagt tttgtatcac ctattatttt ccctaaaatc tggtttagag aagtataaat
    11641 atcatgtctt tccattattt tatttattat gagtcttaaa aatttcaatc aattgttttc
    11701 tatcaatctt accattgtta tttagtggaa attgagcaag actaatgata gattttggta
    11761 tcatatatgg aggtaactgt tcacgcaaat aaacatagac ttgcttttcg tcaactaatc
    11821 ttgattcaac aaaaccaacg agaatatcat cattattatc ttccttgatg gcaagcacta
    11881 ctgtatcaca tttagtaaac tctctaatct tacattcaat ttcaccaagt tctacacgat
    11941 aaccttgaac cttagcctga aaatcaattc ttccaatata ttcaagatct ccatccttgt
    12001 caaactgaca caaatcaccc gttttataaa atctataatc cttattatca atggatatag
    12061 taaggaaagc ttctttattt ttttcaaaaa gctgccaata tccaggagta acttgttcac
    12121 cagccacaca caattcacca attcctttat tcaggactat cccatcgggt gaaataagaa
    12181 cagcttttat tccactcata ggtttcccaa taaacagaat atcatttcgg tttttagttt
    12241 gattgatgtc atcaggcaac ttataataag tacaatagat agtagcttcc gtagggccat
    12301 aaaaatcata aagttcagca ttatacgcac attttttcca atctttcacc aaggagagat
    12361 tagaagcttc ggcagttaga atgcatttct taagagatga catatccaat tcatcaaaat
    12421 acggttttaa aaatctgacc atagaaggag ccatagcacc aaatgtaagt ttgtatcgtt
    12481 ctattaaatc ggcagaacaa gcatacttca tacaatctaa tggtaaagta tagacacatg
    12541 ctccatttaa taaaggcatc aaataagact gtacagacac atcaaatgtc aaatcaaagc
    12601 attgcaagca tctatcttca tgggataaaa cgataccagc attttcaaaa gcggcaacaa
    12661 atgaagtaat attacgtctg ttcaattgaa caccttttgg cttacccgtg ctaccagaag
    12721 taaatagaat atagcacaat gcttcatcat ctatgttgtt aatgacaggg aatacaacat
    12781 ctgtattgga attattttgt ggatatagaa cattatattt atctacatag cgtgacatct
    12841 ctgtagaatc aataatcaat tgaatattca cttgttcgat aatgtcaata catctagcaa
    12901 taggttgcaa gggatgcaag ggaacataag ccagtccttc ataccacaaa gccaagatag
    12961 aagcataggt ataaatatca tcattattaa ccaatcctac cggagtcgtt tcagtatact
    13021 gatttcttat ctcctgttga atctttgcag ttaaaataga aagttcccga taagtataat
    13081 atttatcctt aatacaaaaa caattttgat ctagatactt agccattttt gtactaagtc
    13141 tctccaacac atcaatctta aagttattca tcttctctca tttatctacg ttcgtaacta
    13201 tcaatttgtg accccttagt caaattataa atattagcac ccagatgatc agcatatttg
    13261 cgacactgtt catgggaagc aaaaatattg actatggttt gcaattcctt agtaagtgaa
    13321 ttatgataac caaaagcatc ggttacaggt attatttttg gttcattttc ataaaaatgc
    13381 tgatatacat gtacaagttc attcttatca tttactttca aaccttcgag aaatgtatga
    13441 tcaacaccat aaagataaat agtactatat cccatattaa gcatagcaaa aatagactca
    13501 atagccactg tttgcgcatt aggcatagca tacccttttc tataacagaa atgccttaca
    13561 ttatccgagg caacgtatga tgagaacgta ttcaatacca taattttaat ctttggatta
    13621 ttaatctttg aaaactcacg aaaggacttt tcatattgta tgggtaggaa aattatcatt
    13681 tcccaatcaa tacgattgaa ggaatcaaat agtacctcca atctttccat atatctattc
    13741 tctctcctat ttgtaaaaaa caacggatcc atcaatgtgt agtattgtgg tttaatctcc
    13801 caaaaaagag aatcgttggc cataaagttt accacaataa aatcaactcc tttcagcttt
    13861 ttaatagtct ccatatcatt ttttaaagaa ggtccattac ataacaaata cacgattcgt
    13921 tcttggcgac cttgaaattt aaggccagag aaaagagagt aatgttttac aagatacacg
    13981 aaacatccta ttaggaattt taaatctcga aataatccac gtaatgttat catgattgtt
    14041 taaatttgat tttatttttg aataatttta tagctaaaaa tttaatatta agacgtttat
    14101 caaaattacg aataactaga gcaacgccga gaaatgctac taaaagtgcc attgttcgaa
    14161 acatcaaaga atcgcctatc gataacgcta caataaaagc aacagctaac aaacctaaga
    14221 acaaatactg ttcttttaag tagacagaaa caaaaatcaa agtatattta accctcaaca
    14281 atgtcatgag tgcatgagaa caaacaatac ttatacaagc tcccatgatg ccaattaacg
    14341 gaatcaacaa aatattaagg cctatagtca gcacagcact ccatatactt gaatacagat
    14401 aatacttact ttttcgtaca gcagagaata tgggactaat aatcgtattc atgcataaga
    14461 aaaagagagc taatgaaaga cacggtatat aagtagacga agataagaaa ttattgccta
    14521 caataaaagt taccagccaa tcggaaatat aagataggat gagcactcca aggcatgtaa
    14581 tgattgaaaa aatggctaaa acacgattga agaacaaggg aaaatcgttc attttgtatt
    14641 cttccaatac tgaaatctgc catgaattac cgaatataga aaacactaac gaagctgcat
    14701 ttggaaaacg ttgcgctact gctaaaatac cgataccaga aagtcccact gtaccttcta
    14761 agatgggtct attcaaagaa cccaacaccc accacattaa aacattagga atagttggaa
    14821 tagagtattt aagcatttct tttaaagaaa ccttattgaa ggattttaaa gaaacatatt
    14881 tatataattt tgctataaaa aaagttgtaa tggctactac tacatttgac aataccatgg
    14941 caataagata tccataaacg ccgtttttag gtataaatat aaaagaaaag ataccagtac
    15001 ataatgtgag aagaatacct atcaatgtaa atacatacat tttatctata ctcctacaga
    15061 attgttgcaa atacgtctga atgaatgtaa taaatatcat tatataaatc caaacagtat
    15121 aatctgtaaa actattgctt acgctgaata gattaaaact tgatctaact atataaaata
    15181 gaagtgcagc tactataaat gcaaaaaaag caaatatcaa gcctgaagaa aaatattctt
    15241 tttgacgatg aaatgctacc cctttgggga atataaatat tgaagttgaa atagcggctg
    15301 ttagaaaatc ggttaaaagc gattggtata ttgatatcat atctactacg ccataatcag
    15361 ttacgcttag ccaccgcgtg taaaacggca acatgataaa tgagataatt tttgcgccaa
    15421 aacttccaat aaaaactaac agcgtattct ttcctaactg tttggctctc cccattttat
    15481 atcatagtta tgttattgtt acatgaacgt ttcacaatat cgttaagctc actaatacta
    15541 ttaggataat atatagtaga tccacttttt agtctcactt ctaacgaatt ttttaaaact
    15601 gatttcaatt taaaatctat attcagtaga tttaaaatag agatactgca tttaccaaca
    15661 tttgcagctt caatcagcaa agcagaacac aatccaatat agcaatcaaa caatggaagg
    15721 atgacgttgc ctggaatata cttaggaata gcaggaagca ttttctcaat cgataataaa
    15781 tcatcaaatc ttggatggca ttttaccata aatttatcct ttcctaaagc agataatata
    15841 gaatttataa ttttcccata atcagtttca tcacaaaaac cggctgtaat attcgaacct
    15901 gtaactaata gaatggaacg gttattatta ttcaaattaa gtttttcatt tacataattg
    15961 caaactaaat cattatctac catagcattt ttattaatta cattattctt cttaaaaaac
    16021 ttaggagaaa tagaaggcaa tgtgttatta ccagaatcca ttggtatgat atcagtatta
    16081 taaataatct tatagactag aaacagtttt agtgccttta acgaaattcg ttttttaaag
    16141 caaaaagaag gaaaaggtga ttgaaaataa atcgttgtat ttctactata tttagaaatt
    16201 agccaagttg caagttcacc atatgctgta tgataaaacg taatactttt aatatctata
    16261 tgctcaagtt gattccatat aaattgtttt gccttattag cattcttcca attaatataa
    16321 tgagggtatt ttagaagatt acaattttcc ggcaaattta atttgtcaaa gaacatatat
    16381 atactaggta tatcaacata aatcaaataa cgctgatcgg aattatttag tactgtagta
    16441 agtactatag gaataaacat attactatta caaatcaaaa gatgcatttt atttatcttt
    16501 tactacaaat gtaaactatc aaactcttcc acctcgctaa aaatgaacaa agcatagaac
    16561 tgatcgatta ataattaatt aaaaaatagt tttagttgta taagcgctca atttaggata
    16621 ttccattccg aaagagcact ttagagtgtt ataggaattt tattctttac ataggacgac
    16681 tagaggggtt cccatgggga aaaggccttt gtttagtact gaaagcaaaa cctttctaaa
    16741 ttttcattac aatacatatt ttttaaaatt tacctgcagc gaagatagat ttttttaaat
    16801 tgagtattaa tttgagtgct tacattattt ttctactatt ttcttataaa tagtatttat
    16861 atgtttcatt tgtttctcca ccgtacaaaa tcttccataa tctccctcta caaacgcctt
    16921 agtctgtaaa taaaaaccag gtttaaaatc tatatccaat tgattatcta tttcaacagg
    16981 cttgatagcc acactacctt tttcctggat ctgaagagtt tccatcggtt taaaatacaa
    17041 acgatgcttt gtagtcaata cttctaccac ccaacgaccg ggagcattcc agttagcttg
    17101 atacgagaat agagccccct tgttagtgat acctgctcct gaaaatacag caggtttatg
    17161 ccatgacaat tcccctgcac taaaacaaga aatttcttgg ggttcgcctc ctaggaaaaa
    17221 agcaagatct actacatgag aagaattggc gaagaaccaa ttatcgaaga tattatgcga
    17281 ataatccaat gtttcaatta catgccccca ctcagtaaac tcaaaattaa aagaggttat
    17341 tccaccatct tctttaataa tcttctcagc agccaatacg ctggaataga agcgacggtt
    17401 gtatgcgaga agaacatgag catttttagc ttgtgctaac tgaactacgg gtgtaatttc
    17461 ttcgggacgg caaaatccag gtttttccac caaaatatct tttataccaa agttcagcaa
    17521 acttacagtg acttcagcca actgatctac atttgtagct acaataacct tttgaggagt
    17581 agttggagaa gccgccaggt aattatttaa tccaccagaa actacctctt tagctccggc
    17641 ctcaataaac tcgtctgcat tcttaccact acgtcctact gctataaatt catgttccaa
    17701 ttgatccaag atctttgcat attccaatgc aatggttcct gttcctataa tccaaatcat
    17761 ataattacat cttatattta ttatgtgata gggcatctgt catgcatatc gcccgtcact
    17821 ttattataaa cacccagtat accttttaga aatactttat gatagtttga cgattcggca
    17881 taagtagtaa gtttgcaatt accatttaac agaatttcat cagctacaac accagtcaat
    17941 tgactctgat attttatatg aacgggctgt ttattaccat caacagacat aaatccttcc
    18001 ggctcattaa taataatatg atgagagcca ttgataatag tcatctgatg ctgaacagta
    18061 tcatcatcca cacaagtcag tcgtaaggta cttccattgg gagttgatac atttacgatg
    18121 ccatcaaatt ctatatatcc attacgcctg ctatccttaa cctgaggtat aattccagaa
    18181 aaatcagcga tataggcttt ttctcctgac agcatcataa atatgtctat catgtgtata
    18241 gaattgcaac ataatcccca attagaatca gcatattcca taacaagagg cttttgctta
    18301 tctatcattg aatcgatttc tgcataaaag ccaaatagac gtcgcggaca gtttacccat
    18361 gcgttgacgt gattgatctg caacaactgt gcggcttcat cataatcagc cagtcctgta
    18421 aacaaaaatt tttctaaaat gatattgacc actttcactt ttgcaagtaa actttttaaa
    18481 atcgttaatc gtggttttga actagtagct atgactacca gatctaattc agcaggcaat
    18541 tgatcgataa gttgtatgta ataaatagtt tgattactgt tcacttcacc ttcttcataa
    18601 cgttgttgcg ctatttgaag tgaatttgga ttattatcaa ccacccaaat atcagatttt
    18661 agtttggaca atttgagtcc ttgcaaatga cggctaccca attgtccggc accaataact
    18721 gcaattttat acattgtata ttgtatttca aatttatttc aaatgtttca ccatctccct
    18781 tgccctagcc aattcatcat gctgaccaat atccagccaa tatccactaa taggatagcg
    18841 aatcaccttg tatccctgtt ctatgagttt atccatgaag tcagtggcat taaagaagat
    18901 atcatcagga ataaggtcaa gcaatttgcg tttgataagg tatataccgg cgtttgcata
    18961 ataactgatg gtaggtttct cggtaacgcc cttgatttct cgtcctttga gattgaacac
    19021 accgtatggc accttcacta cgtagggcac agctgccaca ctcatgtcag tatcatgctg
    19081 acagaaatga aggaaaaaat cctcaaaatc aatattcgta aagaggtctg agttcattac
    19141 cagcaccgta tcattgtaaa aagtttccac gaacttgata ctgccaatgg tacctagata
    19201 tttcggttca cgcacagtaa ctatcttcac cccatcacgt tcctcccgga aatgttcctc
    19261 aatctggtcg ccaagatagt taaccgttac agatatatga ttcaaaccgt atgaaagcaa
    19321 acgatcaata ttataatcaa taatacactt gtcacctacc ttaattaggg gcttaggagt
    19381 tttctccgtt aacggacgaa ggcgttcccc cttaccaccg gccattaata cagcatcaat
    19441 tggcaattta gttacataat gttccaaatt gatgatttcg caaatatgat tttcttcatc
    19501 aagtatgggt accaaacgca tccttaaatc acgttggtgg tgaatatcct ccactctatc
    19561 gttcactccg cgacgtaaaa agttaaaatt acgatgcatg gcctcactaa taggagcatc
    19621 cacatctata cctttaatca aggcacgacg cacatcacca tcggtaaggg taccttgcat
    19681 ccttttgttc tcatctacca caaagagcac cagtggttca ttgtgaatct cattgatgca
    19741 gcgaatggca tcaataatag agaaagattg gagaataata tgagagcaat tcatataaat
    19801 taattttcaa taagatgact actgattacc ttttccgcca tataccagtc aaacatacta
    19861 tcaatatcta ttgaatgaag atcatccata acatatttac gtattctatt gagtttggac
    19921 aaacctactt ctttaaggcg agtgctatta atcacataaa tagaaccgtt aaactcccat
    19981 accttaggtg catcctgacg ccgttcaata gtaccatccc ctttgctgat gaccaataag
    20041 ccttcagcat cctcctcaaa actattataa tatggattag ttgccgcttc tttcaccgaa
    20101 acaaccatat ctatgtcaga agtatacaaa gccacagcct ccttcaatga tttagtctca
    20161 cgaaaaggag aagtgggttg caacaaaact actacatcat atttacgacc ttgtttctca
    20221 taaaactcca aagcatggag cagtactcca tttgttcctg cacaatctgt agccaactct
    20281 gcagggcgtt taaaatgaac tttcaagcca taatcctcta caaccttgat aatgacatca
    20341 tcatcagtag aaacacaaat attctcatcg gtggtaagct gacgagccgc atcaatgcta
    20401 tagcatatca acggttttcc atttaattcc ttaacattct tgtgaggtat tcctttactt
    20461 ccaccacgtg caggaattat tacaagtata ttcattacta ttgtctattt ttaaatgata
    20521 ataggttcgt ctatagcata attgcaggta gctatacgcc cgtttaccaa atcccataaa
    20581 gaagctttca aaccaacggt actgcgtttc acagtcatat tatccgccga gagcacctca
    20641 ccttccttta ttggtgtagc cgccacaata cgtttgagca ctacttctga aatttgtttc
    20701 tcactctcat taggctgttt gatgccatca cctaaagctt gttctatatg acggatggcg
    20761 acaaccattt gtttgagttc ctcgggattg agggaggctt tgtggtcagg accgtccatt
    20821 tccttatcaa gcgtaaaatg tttctctatg atttcagctc ccattgctac agctgcaaca
    20881 ggtacttcca cacccattgt atggtctgaa taacctacgg aacaatgaaa tgcatcctta
    20941 agagtttgta tagcccgaag atttacttca tgcatgggac atggatagtt agtagtacaa
    21001 tgaagtaaag aaacactttt agctcctgct tctatcaagg tgcgatatgc tatctctaca
    21061 tcaccgagat acgacattcc tgtagaaagg acaacatcaa tatgtctgct accaacaaga
    21121 cgaagaaaag gaatattggt aacatctccc gatcccagct tgatgaaagg caaattaaaa
    21181 ttacaaagaa agtctagact atctatttca tcaggagtag aaaggaactg gatacctatc
    21241 tcatcacaat gatttttcac tacttcaaaa ttatcatagc tcaattcaag ttctttcaac
    21301 atcttaaact gtgatttggt cttatcggat atgttattct cctgataaac agccaattca
    21361 acattccgag taacaatctt ctctgttttc catgtctgaa atttcacggc atcagctccc
    21421 gcatctttgg cggcattaca gagctgaaga gccaaatcca accgaccatt gtgattcact
    21481 ccggcttcgg ctattatata aacgtgatta atcatgataa tctcttaaaa ggtcaacttc
    21541 cttagttatg actacatcat catacatcaa catgagcaca ccttcatcat aatcaccaat
    21601 gcgaacttca ttggtaacac cattaatgtt attgatgatc agtttaaaga aatcaactcc
    21661 agcaccatac gcatgcaaat aggctccgcc aaaacgagga tttatttcag acagatagta
    21721 ctctccatct ctaaaaaaga aatccatatc gattgctcca gcaaagtcga aaagatgcat
    21781 aaaagactgc acgaagtcaa acaaacgctg gtctttgaat gaaatagttt tactggcccc
    21841 accgatacga gtttcaattt tcttttttga aaaaatagaa accacttcct ttgaataata
    21901 atcaatataa gcatctgcat cgcaatcacc ttgcataaac tcctgaatga tataatcgaa
    21961 agcattctca gcataatagt tttccaaatc ctgcatggta ttgaccttat gcgctccaac
    22021 actaccacta cctgtacgtg gtttgatgaa aacaggaaat tgaatttcac ctttgaagta
    22081 tgcagctttg aaatcatcta attcatggaa agtaagcggt gtattaacac catgattttt
    22141 taaatacagg tacatactgt acttatcaaa gcacaaatca gcagtttgct tagaaggaca
    22201 aagaggaaga acaccaattt cttcaaactt ctttttattt gatgctaaaa gatctatttc
    22261 agggtcgatt aaagtaaaaa tagctttaat atcttctttc ttacaaatac caagtacttc
    22321 ttgaatataa tttggatgtg taattttagg aactacatat tgcttgtttg cgaaaaatat
    22381 tgctggggct accgaccagt tatctgtagc aaccacatta ccactatcac cgatagtctt
    22441 acgcatatct atcattaaac gccctctacg gcccgcatta caacacagaa tattattcat
    22501 aactataaag tttattgtta ttgctttaaa tcattgacag tccattcctc tctaattatc
    22561 tcataaccat ttaaagtttt caaataaact ctaggaaaaa atcgaatgaa cagtggtgat
    22621 aaagtcatag tgtatgcacc gacattttgg taaagtattc tatcaccgac atttagtaat
    22681 ggctgatttt gaagtgtaaa aagcttgtca tactccaaac aactacatcc tacaaccatt
    22741 tgtgaatcaa tgaacacttt ttcctcttgc tttctgatga aagatttaaa atagtctttt
    22801 ttcaggaaaa aagggtccac atcattacga gaaccatcag ttactataat ttgagagtca
    22861 cctatttttt ttgtatcaat gatctccgat aaaaaactaa aaggtgaagc aactattgca
    22921 tttcctggtt ccactatgac tttcatttta gaaacatcaa tcccttcctc taacaaactt
    22981 gaatagatag tgtccacata ttctttataa gtaggtgcat taggcttgtc accaaaataa
    23041 ccaccaccaa catcaatata atcaagttct agacctaatg aattaatgat ccgaatagca
    23101 tatttgcaaa tattcctata aacatttaaa gaacgagtca atgaagtacg atgcagatgc
    23161 aaacctccaa g
//
