LOCUS       gnlProkkaMHGEFPCD_1    12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MHGEFPCD_1.
ACCESSION   gnlProkkaMHGEFPCD_1
VERSION     gnlProkkaMHGEFPCD_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 12:00:49
            Original ID  :: gnl|Prokka|MHGEFPCD_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 631387
            Orig. end    :: 643529
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="2"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             637..2187
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 385.1; E-value: 4.6e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_601"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKASIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADRLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTEEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
     CDS             2550..3812
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 72.2; E-value: 7.2e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_602"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.3e-12, bitscore:
                     45.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.1e-07, bitscore:
                     29.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.6e-06,
                     bitscore: 25.7, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQFLNRAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAEN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             3775..4986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_603"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.4e-15, bitscore:
                     54.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1.4e-05, bitscore: 22.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.2e-09,
                     bitscore: 35.9, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.8e-09, bitscore:
                     33.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVTRAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEACFKECSKHDEEKSVLAEEFIEGQEISIEAVVCQGKVDIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMKCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             5001..5885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.8;
                     E-value: 1.5e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_604"
                     /sec_met_domain="phosphonates (E-value: 5.3e-108, bitscore:
                     358.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 3.2e-126,
                     bitscore: 417.8, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.1e-67, bitscore:
                     225.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALNSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             5943..7142
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value: 2e-69.
                     Score: 226.3. Matches aSDomain:
                     nrpspksdomains_ctg1_605_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 287.3; E-value:
                     3.2e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_605"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.6e-67, bitscore:
                     226.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.1e-09,
                     bitscore: 35.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTNIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYPEIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCAKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPNNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        6039..7106
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_605_Aminotran_1_2.1"
                     /evalue="2.00E-69"
                     /label="ctg1_605_Aminotran_1_2.1"
                     /locus_tag="ctg1_605"
                     /protein_end="388"
                     /protein_start="32"
                     /score="226.3"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYPEIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CAKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPNNIRL
                     NFAIPKDLITEALKRI"
     CDS             7207..8439
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 254.7; E-value: 1.8e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_606"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLVFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSSNPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGH
                     SKVDVTESHRS"
     CDS             8758..9291
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 106.3;
                     E-value: 2.4e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_607"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQDTLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLKEPKYFKTWLIRILLHTIFAMRKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             9273..10715
                     /locus_tag="ctg1_608"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKV
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEQSISFQVDYKDPRNMLAEDYDSSD
                     MKKMKDGRYAGQLRLFTDGSKLKDGDKLPLVITKIKNIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSIDFYDAAKNDAISIYEATDDAGNNYEMTMS
                     NIELGGRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHHHVGITIKKIKQQGRRVIVDYQFTGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSSNKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRPADGK"
ORIGIN
        1 gggaactcgg atgcaccgtc tgacaagcag cgtcaggaat caaagccgga aaaagaggaa
       61 aagccgaaaa agcgggatca cagcgcggcc ccgcagcctg tgatccgcaa caaaaccgcg
      121 gcacagctat ggccgtatgc agccatcgtc attgtgattt cagccgcggc ggcactcgcc
      181 tggctgctcc gggcgcgctg gattccgcac gttacagcag ccagattgaa gcggcgaacg
      241 gatgaagacg tctttttcga cgcatatgcc gcgctgctcc gacagctgaa acgaaaaggg
      301 ttcagcaggg gagacggaga aacgctccgt gattttgccg cgagggttga cgaggcgcac
      361 catacaaacg acatgtccga gctgacgctg cgctatgagc gtgcgttata ccgcagcgat
      421 aatgccgcaa agctttggaa tgaatcggga cagttgtggg aaaatataat taaaagaaga
      481 tagtcttgac cgcatatcgt cctgttgtta gaataaatga atgttaaatg ggagcccggg
      541 agcgttaaaa agccgggctt ccggacaagt cttgccgaca gagggctgaa cgtgtgtcct
      601 ccgttttttc tgtgtcaaaa acttagagga gattaggtga caaccatgac gaagttagtg
      661 aatgaaatga ttcttgttct tgatttcggc agtcagtata accagctgat tacccgccgg
      721 atccgtgaat ttggcgtata tagcgagctg catccccata cgttgacagc tgaggaaatc
      781 aaagaaatga atccaaaagg aattatcctt tcaggcggac caaacagtgt atatgatgaa
      841 gggtctttcc gctgtgatga aaaaatcttt gaacttgata ttcctgtatt gggcatctgc
      901 tacggcatgc agctgatgac tcattacctc ggagggaaag tcgaggcggc aagccagcgc
      961 gaatacggaa aagcgagcat tcagattcaa ggaactcctg acttgttcaa agatcttccg
     1021 gaagaacaag ttgtctggat gagccacggc gacttagtcg tacaagtgcc ggaagggttt
     1081 acggtagacg cgacaagcca tcactgcccg aactcggcga tgagcaaaaa agacaaaaaa
     1141 tggtacggtg ttcagttcca tccggaagtc cgtcattcag aatacggaaa tgaccttctg
     1201 aaaaactttg tcttcgggcc ttgtgaatgt aaaggcgaat ggtcaatgga aaactttatc
     1261 gaaatcgaaa tgcaaaaaat ccgcgaaacc gtcggagaca aacaagtgct ttgcgctttg
     1321 agcggcggag tcgattcttc tgtcgtagcc gttttgattc ataaagcgat cggcgaccag
     1381 ctgacttgta ttttcgtaga tcacggcctt ctccgcaaag gcgaagcgga aggcgtcatg
     1441 aaaacgttca gcgaaggctt taatatgaat gtcattaaag ttgatgcgaa agacagattc
     1501 ttaaacaagc tgaaaggtgt ttctgatcct gagcaaaaac gcaaaatcat cggcaacgaa
     1561 ttcatttacg tatttgatga tgaagcggac aggctgaaag gaatcgacta ccttgcgcaa
     1621 ggaacgcttt acacagacat tattgaaagc ggaacggcaa ctgcgcaaac gatcaaatcg
     1681 caccacaatg tcggcggact tcctgaagat atgcaatttg aactgatcga accgctgaac
     1741 actcttttca aagatgaagt gcgcgcgctc ggcacagagc tcggcatccc ggatgatatc
     1801 gtatggcgtc agccgttccc gggccctgga cttggcatcc gcgtactcgg cgaagtaacg
     1861 gaagaaaaac ttgagatcgt tcgtgaatca gacgcgattc tgcgtgaaga agtggcgaac
     1921 cacggccttg agcgcgacat ctggcagtac ttcacggttc ttcctgacat ccgcagcgtc
     1981 ggcgtcatgg gagatgcgag aacgtatgat tacacaatcg gtatccgtgc cgtaacatca
     2041 attgacggca tgacatctga ctgggcgcgt atcccttggg atgtgcttga agtgatttcg
     2101 acacggatcg tcaatgaagt gaaacacatc aacagagtgg tgtacgatat tacttctaag
     2161 ccgcctgcaa caattgagtg ggaataatga gaaaagcctc aaatctttta tttataaaga
     2221 tttgaggctt ttttaattta catggttcta ggaataatgg gccttttatc attaacaccg
     2281 gagaagatgt acagcagttt tttatatatt cgagtttttt aatcagttgt attcctaata
     2341 ttctccctat aatttcattt tttctaataa aactgaattc ataaaatatt catttaataa
     2401 caaataatgt atgttattat gaatatatac aaataaaaca tatgatggtt tgagttttcc
     2461 aaggggtttt ttatcttctg cattcagttc tttagaaacg cagaaggttt ctaatttgta
     2521 gaaaaaaatg ttgaaagagg ctcggaagga tggaaaaaca tattttattt tttaatgcta
     2581 cttatattaa aaaaatttct actttggaga ctgctaaaaa tttgggcttg acggtttctg
     2641 ttgtcggccc tgaactgcct gaatggtcgc ggccattcgt tgaccattac atttccgcaa
     2701 atacttatca gattgatgag actatagctg ttctgaagga aactgccaaa gaaaatcctt
     2761 ttgatggagt cattacattc tgggatagag atgtggttcc ggtggcggta actgcccgag
     2821 aacttaactt aaagggcagt ccggtggaag cggcagaacg ggctcgaaac aaatggaaga
     2881 tgcgtcaatt tttgaaccgc gcacaagttc ctcatccaaa atattgcaaa tttacaaatt
     2941 ggaccgaatt atatcatgca agcattgata tggaataccc attgatcgtt aaacctgtgg
     3001 gtgcttctgc cagtaaaggc gtattccgaa tatcaaagcc tgaagattta aaccgcgcat
     3061 atcagcagct gttaaacgct gcggtgccgg aaaacgataa aatgttttct ttttatcaaa
     3121 acgagtatat tgttgaagag tttatgaacg gacaagaagt cagcattgag ggagtgattt
     3181 ccgacggagt cattcacttt gcaggtgtta ctgaaaaatg gacggatcag tatttcgaag
     3241 aataccagca tgcatttccc gccaggctgc cggaggctgt ggaacgtgaa ttattccaca
     3301 tcaccagtga agggataaaa gctttggagc tgaacaattg tggttttcat gccgaggtca
     3361 tgatcacaga gaaagggtgc aagattatcg agatcaacgg tcgtctgggc ggcgatttta
     3421 ttactaccca tttggttcct ctagccaaag gtataaatat aacgcgcgca aacctattgg
     3481 ctgtattagg agaaacaata agctttgaag cttcgaaaag aagagctgcc tgcgtcaggt
     3541 ttttaattgc agaccgtgct ggtgtgatag aaaagtggga aggtgtcgaa tcgatcaaag
     3601 aaatgcccgg ggtcgttgaa tttgttttag aaaagcagcc gggcgatcat gttggcctgc
     3661 cgcctgaaaa gtttcatgat tcccggattg cttatgtcat cacagaagcc gaagatacag
     3721 aaaaagcgat cgaatatgct gaaaatgctt tatctgaagt gaggtgtttc atcaatggag
     3781 aggaaaagac tgttcctgat cgggattcct gaaacgcata ttgagaaggc cgttacgagg
     3841 gcaaaacaac ttggttttga cgtcttatta ggagatacag aagcttcatt aaaaaaatat
     3901 gagcatttaa taaaggaagc tgaccaaaaa atcgcattag attataccaa tcatgagaat
     3961 ctattctcag tcgctaaaga aatccatgac aaagagcctt tagatgccat atttactttc
     4021 aaagaagccg gcttattcaa tgtatccaaa cttcagcagg catttcattt aaaaggaaat
     4081 cctccgtctg tggtgcaagc atgccttgat aaatatacaa cgcgccggct tttaaaaaag
     4141 gcaggactaa actctcccga ttttggattg tgcaggagcg tggaagacgt atacgatttt
     4201 tggaatacat ctcagcatcc tatcatttta aagccgagat ctcagcaagg cagtataggc
     4261 gtcataaaag ttgagaaaaa agaggacatt gaggcgtgtt ttaaagagtg ttcaaaacat
     4321 gacgaggaga agtcagtatt agccgaagaa tttatagaag ggcaggaaat ttcaatagaa
     4381 gccgttgtct gccaaggcaa ggtcgacata tttggtgtga ccgaaaagtt gctatacccc
     4441 gggacttttg tagaatccgg gcatatatcg ccgtataaac ataaagaaaa acatcaggat
     4501 ttgtataaga atctggtcaa ggaagttgtt catgccatgg ggatcgtatt tggccccttg
     4561 catattgaag ggtatcacac aaataaagga tttgtggttg gcgaggtaca cacccgctat
     4621 ggcggagaca acatagtgac cattacagaa atcgccatga aatgtgatat gcatacacct
     4681 atttttgcgg aactggcggg catcccatat caaccggaaa ggaaacatgc tcaaagcgaa
     4741 gtatgcgccg ttcgtttttt agaaacgaac caaggggttg tacgcgcaat caaagggatc
     4801 agcgatctca aaatgatggg gaatgtagta gattttcatg tgaattgcag tgtcggtgat
     4861 agaatcagac cgatcaaaaa cagctacgat agagcaggat ggatgattgt aaaggggaaa
     4921 aatgagcgag aagtcaatca cgcattacat gatgcgattg acaaaataaa aataatcatt
     4981 aggtgaaggg gagaatgatg gtgaaaaaca gaaaatcatc aatttttaga gatgctttaa
     5041 acagtaaagg tttggtgaaa gttgcgggag ctcatgacgg tttaagcgcc aaattagcag
     5101 agaaaaacgg atttaatgcc gtatgggcaa gcggtttggg aatctcggct gtgcaaactg
     5161 tacctgatgc cagtatatta acgatgactg aatttcttga agccgccgtc attatgaatg
     5221 aatcatgcaa tttgccggtc atcgctgact gtgattccgg ctacgggaac attcacaatg
     5281 tcacccgcat gatcaaaaaa tacgaagctg ctggtattgc cggagtttgt attgaagata
     5341 aagtatatcc aaaattaaac tcatttgacg acagacaaca gatccttgtc agtactgaag
     5401 aattttgcgc aaaaattaga gccgcaaaga tggctcagca aaatgacgat tttgtattga
     5461 ttgcccgtgt cgaagcttta attgctaaat tgggtcaaga agaagcctat acaagagcaa
     5521 aagcttatgt tcatgctgga gcagatgcaa ttttaattca ttcaaaagaa caatcgcctg
     5581 atgaaattat tgagtttgtt aacaattggg acgtggatgc gccgttggtt gtggttccga
     5641 ctaaatatcc gacgctctca atggaacagc ttgagaaatt gggagtgaag gtttccatct
     5701 atgcgaatca ggcgttgcgc gcttctgtta aggctataaa tgatacattc gaaagcatta
     5761 taaataataa atcgtctttg cagattgaaa atgacatcgt gagcgttaat gagatatttg
     5821 acattcaaga cgttccgggg atgaagcaac tggagcgttt gatccataga cagccggcta
     5881 actgaggttt ttgtatcgtg ctattttaag aatggcccat aaagacattg gaggcgtttg
     5941 aattgaataa aagattatcc gatagagtca tgaatataaa accttcggcc actatgtcat
     6001 taaatgccaa aacgaatata atggtaaaag aaggaaaaga cattataaat atgagtgtcg
     6061 gagaaccgga tcttcatccg ccattaacag cctcatatgc aggaattcag gcaatagtga
     6121 aggggaaaac cgggtatacg ccggcagcag ggctgattga attaagagaa tccattgtgc
     6181 gatatctgct taacgaacga ggtttagaat ataaaccaaa ccaaataatt gcatctgccg
     6241 ggggaaaaca gccgctatat aatgtttttc aagcaatttg tgatcaagac gacgaagtta
     6301 tcctcccttc accttactgg gtatcttatc cggaacaaat caaactgtcg ggggcggttc
     6361 ctgttattgt aagctgtgat gaaactacaa attttaaaat cacacccgag aagcttgcag
     6421 aagtaattac ccctaagaca aaagctgttg ttatcacatc tcccaataat ccgacagggt
     6481 ccgtttattc agaaaatgaa ctgaaagctt taggaaatgt gttgaaagat tatcctgaaa
     6541 tttttatcat ttccgacgaa atttatgatc agtttgtgta tgagggcaag catatcagtc
     6601 tgccgctcat ttttcccgaa ttgctgaatc ggaccatcat aacgaatgga ttttccaaag
     6661 tctttgcaat gactggatgg aggctcggct atatcgcagc cccatcggat atagccgaag
     6721 ccattgccag ctttcaaagc catgctacag gcagcccgtc aactatttct caatatgccg
     6781 gtatttctgc tttaaacggt tttgacaagt cgatggtcga agaatacaaa aaaagacgcg
     6841 atatattagt cgatggttta aatcaaattg agggcattca atgcgccaaa ccaaatggag
     6901 ccttttatgc gtttccgaat gtttcacaat ttttcggaac aatgtttgaa gatcaacaaa
     6961 taattgatgc ggagacattt tgtcatcttc tgttggaaaa acagcacgtg tcagctgttc
     7021 ccggcacagc attcggagag ccgaacaaca ttcgtttgaa ttttgccatc ccaaaggatc
     7081 ttatcacaga ggctttgaaa agaattaata attttacaac tcagctggca gttaaggtat
     7141 aacagagcgc tgaaagctta aacgagcctc tttatatctg catctaatgt ttaggcaggt
     7201 ggttttttga aaggcatacg attaagaatt caccctgtgg gctggaatat cattttaggc
     7261 accttgttta gcagaatgtc agtctcgatg agcattccct tcctttctat ttacctaaca
     7321 caagtaaaag gtgtttctcc tgctttgacc ggcatcattg tttcagtaag ttcgctggct
     7381 gggattgtaa tgagctttta cggagggtat ttgtctgatc tttttggcag gaaaattgtg
     7441 atgataacgt ctgtattttg ttgggcgctt gtttttgtaa gttttatgtt tgcagatagt
     7501 gtactcgcat tttttgtcat caatgcgctt aacgggctgt gtcaatctat ctttgaaccg
     7561 gcgtcaagag cattattatc cgatataagc aaagaagaaa atcgtttgaa gatgtttaat
     7621 ttgcggtata ctgcgattaa tatcggcgta gttttcggtc ctcttttagg ccttagattg
     7681 ggagctgcca agacggctct cccatttctg ttcgcaggtt ttacatattt tctttatggt
     7741 ctatctctcg tattttcatt ccgaaaattt aaattagacg agaacaatcg aaaagaaaat
     7801 aaaacgacta ttgctacggc ttttaatgtg acaaggaaag acaaggtttt tcttatcaca
     7861 ttacttggag tgatattatc aatatccgga tatgcgcact tttctacaac attgccccaa
     7921 tattttgccg ccaaaataga ggacggggtg accatatttt catggctttt agctttgaat
     7981 gcaattgtcg tcttaattgt tcaataccct attgtgaata tcatgaaaaa gttcccgccg
     8041 attcattcaa tcattctggg aaatgcttta attagtttca gtttattatt tttttcgcta
     8101 tcgtccaacc cattcatatg gggctctatc gtcgtgtttt tcacaatagg ggaagttttg
     8161 attttttcga tggttgatat gctggtggat gaaattgcaa aaccaggctt caaagggaca
     8221 tactttggag cagcaggctt taaccgttta ggaaatgtaa tcggtccttg gctgggaggg
     8281 attcttcttt ccttttttgg tgtaaacggg tccttctata tgtttttgat catttttata
     8341 acgacagcct cgggaattcc ggttttattt ttggcaaaaa aacatcttga taagagcgga
     8401 cattcaaaag ttgatgtaac agaatctcat aggagttaaa tgttttaaca caatgaagaa
     8461 ttaatggcaa agtctttgaa cctcaaaggt ttaaaggctt ttttcttttc agcagcgccc
     8521 catcagaatg ggaaacaaga gtgtttatat ttttggggag aggaatacag actgaacggc
     8581 gaacaaagaa ggtattaatc taagggactg accccataag atgagacaaa taaaaaacac
     8641 cttcaagttt gaaaacggat cgttgttatc cgaaattaga ctttgaggcg tttttttttc
     8701 atctttttga aaccgttttg ccttgattca tatctaacag cataggaggt ggataaggtg
     8761 aaggaagaac gattgatcaa aaaggcgaaa aaaggtgatg ccgcagcctt tgaaaaactg
     8821 atcaccgcac accaggatac tttatataaa acagcttatc tctatttgca tcacaaggaa
     8881 gatacgctgg acgctgttca ggaaacggct tacaaggctt ttcttcatat cgcgcagctg
     8941 aaggagccga aatattttaa aacgtggctg atccggattt tgcttcatac gatttttgcg
     9001 atgaggaaaa agcacggaga cgtcatcccg tttgagccgc agcatgatac gcgcgcggag
     9061 aataagaaca ttgaagaata catagatctt cggaatgccc tggaaacgct tgacgaacat
     9121 atacagctga ccattcagct ttattatttt caagatttct cgattgctat gatcgctgaa
     9181 cagaccggta tggcggaagg cactgtaaaa acgcatctgc acagggcgag aaaagcattg
     9241 aagcaggagc tggaaaagga ggataaacat atatggaaaa gcatcaaatg aagcaattgt
     9301 atcaggacat tgacgtgccg aaagctgaat tgaaaaatgt gatacacagc gccgctgtcc
     9361 gtgccggaaa agaaggcgcc gtcagacgga gatggggacg aaaagtgata aacggactcg
     9421 cggttgctgc tgctttgttt attctgtatc tgtcctcagg cttattcatg ccctccgtta
     9481 atacggctat gggaaacatt cctgttgccg gacaaattta cagtctgttt caggataagg
     9541 caggttctgc gctgtttaaa agcaatttgg tgacaaaact gaatgagaaa gcggaatcac
     9601 gcggaatcac ggtgacagtg aaaagtgtgt attacgacag cggacagctc gtttacaatt
     9661 ttaccgttga caatttgaaa tcagatgagc agagcatctc ttttcaagtt gattataaag
     9721 atccacggaa tatgttagca gaggattatg acagcagtga tatgaaaaaa atgaaagacg
     9781 gacggtacgc gggacagctt cgcctgttca cggacggctc aaagctgaaa gacggtgata
     9841 agcttccgct tgtcattaca aaaatcaaga acatcccggg aaactggcgc tttacactcc
     9901 cgatcaaaaa acaaaagtcc gtttctcttg aaggaacgaa agctgtgaat gtaaatcacg
     9961 gattataccg ctttttcgat atccgggcgg aaaacggaac gacgggatcg gctctcctgt
    10021 attctatcga cttctatgat gcagccaaaa atgatgccat ctcgatttac gaggcaacgg
    10081 atgatgccgg aaacaattat gaaatgacga tgtcgaatat tgaacttggc ggcagaaaga
    10141 atcttcccgg cggcgggaaa agaatacgcg gccaaactca attcagcaaa ccgatagacc
    10201 cgaaagcgaa aacacttttc ataacgggcg atataaaaac agaatcagag ccgggagaaa
    10261 tcgtgcctct gaaaacaaaa ctgcccgtca gttataaaac gaaacatcat catgtcggca
    10321 tcaccatcaa aaagatcaaa cagcaaggca gacgggtgat cgtcgattat caattcacag
    10381 gaattaatta cagcaaagcg gatgaagatc agctgatcaa tgtcggtgag tcaatcggtc
    10441 tcggcaatac gaaaaaaatg aaaacctggc catcgcttaa tgagtatgaa aaaggctatt
    10501 atctgaaagg gaataaggcg aaagtcacga atcttaaaac gggtgaaatg gaatccgttt
    10561 ttgaattaga tgattcatcc aataaagact attcgttgcg cgatttctca ttcgattcat
    10621 acgctttgta cgtcaatcaa acggttatga acttgctggc ggatgataag gggatcacat
    10681 tcgcggtgcc ggttcggcct gcggacggaa aatgatgtct ggaaggcggc ttttgccgtc
    10741 ttccattttt ggtcaattaa cgaataaacc aaattttttt aacgggattg ttcgtttttt
    10801 tattgagttt tcaaaattga attgatacaa tagactcaga aatcaaatat gcagatatcg
    10861 tataatggcg gggatatggc ccgcaagttt ctaccaagct accgtaaatg gcttgactac
    10921 ggatcaatct caatcgtttg atataaataa tccattctta tttattcaga ctgaacgtat
    10981 gtagtcaagc gtcccaaatg tatttggggc gttttttatt tggcggataa cgggcagaat
    11041 aaatgggaga gaatgaagga ggcaattggc ttgaagcaat tttttcagtt tgatgagctg
    11101 gggacaagct atcgtaatga aatcatcggc ggtttaacga cctttttgtc aatggcgtac
    11161 attctgttcg tcaatccgct gacattgtct ttaaacggtg tgaagggatt tccggaagca
    11221 ttaaaaattg atcagggcgc ggtgttcacc gctacagcct tggcatctgc ggccggctgt
    11281 attttaatgg ggctcattgc aaagtatccg atcgcgattg cgccgggtat gggattaaat
    11341 gcgttttttg ctttctctgt cgtcctcggc atggggattt catggcaggc tgcgctttcc
    11401 ggcgtcttga tttccggaat tatcttcgtg gcgctgtcac tgacgggatt gcgggaaaaa
    11461 atcattaatg cgattccgcc tgagctgaaa ttggcggtcg gcgcgggtat cggtttgttt
    11521 atcacatttg tcggtttgca gggttcgggc attattgaag cgaactcatc gactttggtg
    11581 tctatcggca atattcacag cggccctgtg ctgctgacgg ttttcggtgt tattgtgacg
    11641 gtcattctga tggtgcttcg cgtaaacggc ggcgtattta tcggaatgct tctgacggcg
    11701 gttgccggca tggtctgcgg gctgattccg gttccgacgc acattgtcgg cagcgtgccg
    11761 agtcttgcgc cgactttcgg acaggcgtgg atgcatcttc cggatatctt ctccgtccaa
    11821 atgctgattg tcattttaac tttcttgttc gtcgggtttt tcgatacggc cggaacgctg
    11881 gtggctgtag cgacacaggc cgggctgatg aaggaaaaca aacttccgcg tgcgggaaga
    11941 gcgcttctgg cagattcgac atcaatcgtt atcggagccg tactcggtac gtctacaacg
    12001 acttcttatg ttgaatccag ctcaggcgtt gcggcggggg cgcgctccgg cttcgcggct
    12061 gttgtgacgg gcattctctt tttgctggcg atgtttttct cgccgcttct gtcagttgtc
    12121 accacgaatg tgacggctcc gg
//
