LOCUS       gnlProkkaEKFBEHAF_6    16744 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EKFBEHAF_6.
ACCESSION   gnlProkkaEKFBEHAF_6
VERSION     gnlProkkaEKFBEHAF_6
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 12:04:28
            Original ID  :: gnl|Prokka|EKFBEHAF_6
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16744
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16744
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4318:6744]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4319..6744
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..16744
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16744
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             209..310
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             480..749
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             909..1208
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1308..2219)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2449..2538)
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2535..3137)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.4e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALKLDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3231..4322)
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4319..5509)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="Fer4_12 (E-value: 3.9e-07, bitscore: 22.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.9e-20, bitscore: 64.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.2e-13, bitscore:
                     43.3, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLKFATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQ
                     NARKHVAKLKKHNILSFPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQA
                     KDNGVLSVSILGGEPTRYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYIT
                     PVLSLQTLDPKLNFELMGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFC
                     IENKIDRFSVANYSEVTGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLF
                     TAYPELINNSIEFSEFGEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDL
                     LDVWYDDPLYGGIRSFRTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(5478..5639)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="Streptide_RRE (E-value: 1.6e-14, bitscore:
                     46.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEICYVLF"
     CDS             complement(5709..5801)
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(5884..6744)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(6984..7820)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 264.5; E-value: 1.5e-80)"
                     /gene_kind="other"
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYCYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(7814..7975)
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MGRKPKKKLEEMERLQAENEYLRAENAVLKKLRELRLREEKEQEE
                     KRKLSEDW"
     CDS             complement(8001..8378)
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYYC"
     CDS             complement(8557..8715)
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(8727..8858)
                     /locus_tag="ctg1_16"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(8868..9500)
                     /locus_tag="ctg1_17"
                     /transl_table=11
                     /translation="MKSLSISSSFFSISTSSTPQLTANSIGQHSTAKQSRKEIELAAAK
                     LVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQNDAM
                     NQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTNQTETRTVNL
                     NYSKLPGKLLVNQVQVWKSGLDDLDKATPKTLEESSSVPSLPNTTTK"
     CDS             complement(9780..12959)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 497.1; E-value: 1.9e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg1_18"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDRFQKSLEERLRQSNKDMDKRQAQIDSHFASQVWSE
                     EELAVLASTPASEKLARLEEFLSQRQESLTEQKSILKAAHEDLAQLQKSFQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELAIQSEDFLQKEEELETWKEDIIYSQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLESLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLMIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVTKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(12956..14164)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.5; E-value: 8.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_19"
                     /sec_met_domain="Metallophos_2 (E-value: 4.3e-10, bitscore:
                     31.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMEKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 aactattcat tagaatagga gacataacat gaaacactat ccagacgaaa cacgataaaa
       61 aattgttcga ctgcacattc aagacggatg aacattaaaa agcttagctg ctgaatatgg
      121 cgtatcccaa gcctcaatct ctaattgggt aagacattat cgcaaagaat gccaaactaa
      181 taataaagaa aaatcacagc ttgaactcat ggaggaggtt cgtaaattac gtcaagaaaa
      241 ggcagagctt gaaaaggaaa atgatttctt aaaaaaagca gcggcattct ttgcaaagga
      301 aatcgattag aggcatatcg ttttattgat aactataaag aagattttgg tttgcgttgg
      361 ttgttcttgc atatgaatat tcatcccaat gcttattata attatcttaa aaagacaagg
      421 actaactatc atcgtcaaaa gaaagctatt cttaatacta ttcgagatat ctaccatgag
      481 tgcaatggaa agaagtaaat caattcttcg aaacagaaag catcaaactt tctgatatag
      541 agccttcgaa agttagttat agggaggtac aaaggaatca aatcaatacc actatttata
      601 atgaaaaagg taatataaag gatattgata ctagcattat aagagatatg tacgataaaa
      661 gcaaacctac tttaaaacag ggagcctata tatccgctat agcagcttct ctagaagggg
      721 ggtactgcat ttataacagc aataattaaa aaaagcgctt agggaaaact attagtgagt
      781 ttacaaaaga cgattgtctt gaaatttcta aagatagtgg aattggagct ataaaaggaa
      841 gtactcgagg cattacgata tacgccctaa cgaattacac agctactcct gcagcagtag
      901 caagttcatt gtgcactgct tcatttggta tcgctaaaga agcatacaaa ttccgtaaaa
      961 acttaatcac aaaagaagaa tttttactaa attcgcaaat attatgtgtt gaagtatcag
     1021 ttagtgcatt atcctcaata ttaggacatg ctgtaattcc aatacctatt ttaggatccg
     1081 ttattggaaa taatatagga actttcctat atgaaatcgc taaagataat ctcacaatga
     1141 aagagaaatt actgatagca gattatttca aagagataca agaatataac tattttttag
     1201 ataattaatt tgaattatat aatcatcaac ttcagagaga ttaagaatta ctataaactt
     1261 ttagggaagg cattttctcc tgactataat atcgcttttc agggatctta tgaattttta
     1321 aatatgtttt ttaaaaatac gttaacctct cctattttct ctgcttcagg taaatagata
     1381 gaaacggttg tcgaataaac aaaagaaggt acactcacaa ttgaaagcaa ttgactaata
     1441 actgcataaa tagccaacaa ttctactcct aatctcgaca tcaaggcatc aaacaccata
     1501 ataaacaaaa cactctccag aatttcttga ccaaccaaag gaataccaaa tgttattaat
     1561 tcaaatttag ttgtagatgt aatggataaa gccttcaaaa tcattggata aaccataaac
     1621 aagtaactaa gcgatatgaa agctaaggat acaatcgttg atatggctgc tcccttaatt
     1681 ccgatttgtg gtaccagtac ataatttaac acaacatcta ttaatgaact gataagtcca
     1741 acccacataa ttggttttgt tttcttttga actcttaata aatttgtcag cgaaaagttt
     1801 aataatgtca atccgatata tggagacatg aagactaaat aaatggtgga taaggacaat
     1861 agttgccctt taaatccata gagctgcttc aagattacat ttccaaaaat aatgacaaaa
     1921 accgcaaagg caactccgat aattaaatct aaggttagat ttgatttcaa taaatcatca
     1981 aacctgttag tttgccgatt agagtacgcc ttagagcttt taatattaaa tgacaaactg
     2041 aatgctccta aaagtccacc aaaagcaaat aagagattct gaataatgga aattcctgac
     2101 agagcaattg aggaattgtt cacagcaaaa tgcaatgcta tctgcccaat aattacttga
     2161 ccaatatttg ttaaaactaa gggaaaggca aatttgttaa tttcttttga atctatcatt
     2221 tttcctctct aaaaggcttc aaatgtaagt aaagatcaga tttaactaaa tttgcataaa
     2281 taatatgcaa aataggagtt tcttctaaaa atgaaataat tgcctgctta caatcattag
     2341 cagatacctc ataatcttgc tgtaatagtt ctacaatctt gtctaaagaa aaatttttag
     2401 aaatgcaata aagtatttct gctcctattt catcaaatga atagtactct aatcaagtag
     2461 atcgtatcct atgtattcat ctgctacttt atttacaatg aaatctctct tacctcttat
     2521 cacaaaatgt tctttcatac gactactcca cctccttttt gttcataaaa gcaggctaaa
     2581 tcagagccca gtaacgttcc atctaatttc aaggcactgc atcgacatcc cccaccacac
     2641 catggtaggg gacattctga acatttccca gaaatatcat caaatgtaat tgatcttagt
     2701 ttattaaata cagcagaatg gtgccaaatt tcgctaaact tttgttcttt aacatttcca
     2761 gcaactaatt catctatacc attcatcaag tcacacccgt atacatctcc tttatgatta
     2821 attgaacatg ctctaactcc agcttgacaa gatatttccc ttggcttatc aaaatttata
     2881 tctacttttt gatgccaaac attttctaat aaatctgatc tattataaaa tgcaagcgga
     2941 aaataatgtg tcaaaaaaac atcactttca ttaggaggaa caattttaaa tttaactttg
     3001 aactctcctt tagaaatccg ctctgttaaa tcaagaaaaa caggatacca ttgtttttta
     3061 tctgctaaaa tactaccgtc attagcccta ccagtaggac aaataaccat aactgacata
     3121 tactcaatac caagcatatc attcaatctt atactctaaa gaaaatatct gctaaatttg
     3181 caaacaattg tgctatcaat aatttggcaa atgaattaga aatacaactt ttaagttctt
     3241 ttctctctgt tagaaaatga ataagatact aagcaacaaa gagctactat accaaatatt
     3301 aaataattgc tcctaatact aaagttatca gcaaaaatac cagctaggaa atcagctaac
     3361 ataaaactaa tcgaaataaa caaattatat actgaccatg atactgctct atttttttct
     3421 attgacatat taaatttata ataaaaatga ttattgtagt tggaattaag aacacgcatt
     3481 aataaaagga ttataatttg gatgattaga ttagtttgaa aaaacatgag tatagctaat
     3541 actggtaaca tcaagcttac ttcaaactta atttttagat aactccccaa agccatagat
     3601 atattaaaca taaatagtat aattcccagc atatctagtg aaagtccctg ttcatttaag
     3661 aatatccctg cataagaatt gctaatcata attagagttg agaatgctac tcctaatatt
     3721 attaataacc atggaatatt ttgaatatta tcgaggctaa aaaatttttg tttattattt
     3781 tgttcctttt taatctcggg taatcctatt aaatataata aactgaaaat tacaaataca
     3841 atggatataa taataggata aatataattc ctatgcaata aaggtggaga tataatcgta
     3901 ataatagcaa taaaaatata ttttaatgtg ttgagatttt tcaaaaatga tttatataca
     3961 acttcgtcat caattatttc aaaattataa gaaataagaa ctcctgaaga taatgattct
     4021 gacaatccaa aaaatatcgc tgaaatatat attatatttg attttccaaa caataggccc
     4081 cataatgcta aaattaataa taaatttgaa atagccaaaa ttttcttgta accaatctta
     4141 cttgaaatat aacttaaagg aatatcaaaa actgagccac atagctcagt aataactgat
     4201 aaagtagcta tttctgtgaa cgaaaaacct aagtgcttta atagtaaaat tcctacaaag
     4261 tagtacggta atccagatag aaacatattc attccgtata aattaaaaat cttcttactc
     4321 ataagttaca aactgggtct ctaaaatatt ttggactctt ctccttaatc aagttaacat
     4381 agcagccacc ctcgcaaatt tttaacaatc cacaagataa acacttagaa ttcttcgttc
     4441 taaaagaacg aatccctcca tacaacggat catcatacca aacatctaac aaatcttttt
     4501 caaaggcatt ctgcttagtt tgattaactc ctaaaaaagc aatgcaaggc aagatatccc
     4561 cattagacat tatttccatc ttagtatatt ttgcacgaca tccataatac atttcgccaa
     4621 actctgaaaa ttcaattgaa ttatttatca actccggata agcggtgaaa agatgacatc
     4681 cctcagtagc aaaatttaaa ttagcttccc gttgagttat ataatctgta acatactcat
     4741 tcaaccttct caaatcagct aaatcgtatt ttttctttat tttcgtatat cctgttacct
     4801 cagaataatt agctactgaa aatctatcta ttttattctc tatacaaaaa tcaaccaatt
     4861 ctataatctg ctcatagctt tgctttgtat acactgcatt aattctacat ttttttccaa
     4921 cctctttaaa gtacttcgct aatttaattt gtctatcagg tctcaccccc attaattcaa
     4981 aatttaattt aggatctaaa gtctgcaaag ataaaaccgg tgtaatatat ttagatttag
     5041 ctagaatttc cactgtactt ttctttatta attgggcatt agttgttata gtagtcttta
     5101 tcttcagttc ttcacaagct atcaacaaat tatcaatatc aaaatatcta gtcggttccc
     5161 ctcctaaaat tgaaacactt aacactccat tatcttttgc ttggcgcaaa attctttccc
     5221 aatctttagc aggtttggca tttctatctt cacgatttgc taaaaaacaa aaaccacatt
     5281 ttaaatcaca gtacatactg gggtatatta ctagttcaag cggaaaactc aatatgttat
     5341 gtttttttaa ttttgctaca tgctttctcg cattttgaag agtctcgtca ggatttttcg
     5401 atgatccctc aatattatta tcagaataga tatttaataa gagtactcgc tctagtttcc
     5461 ctgcttttat ttctttctta aaaaaggacg tagcaaattt caaaaccatg attttgaacc
     5521 aaataaagaa aataagcttc actctcatct aactcaattc ggtcaaaagt tactttattt
     5581 atcaaaattc caccaaactt ttctagtcta aataaaaaat cttctgaaat tgtcatcata
     5641 ttgaatacct ttctaaaaaa gcagaggaaa atatagcctc tgcttaactt atgggataaa
     5701 ttactttatc actcccagcc gtcacctttt gccatcacct tccagccgtc accttttgcc
     5761 attgaactag actcaaggac tttttcaagc tctttagaca tatttggtac tcctttcgaa
     5821 tatgatactg tgattatatt tcttttcaac acttacaata aaatattccc atatttgcat
     5881 tttctaacta ctagctaaaa ttttttctaa atgtccttca taagtctttg ctaagtgatg
     5941 acttcctgct aatttcatcg ctccaacaca cttcttcatt tcaataattg ctttcacatt
     6001 tccatcctct ttatattgat aaagattttg tgcatactta aagactaaac gttcatatac
     6061 ttctgtctca ataaaaaagc attgatttag ctgcttttca aaatataaag catccataaa
     6121 tttttctctt tcaacacatg taatatatcc atttaaaagc atcgttgaaa ttaatcgtct
     6181 gttatttgga atttctttgt aaaaatcaga acgcctaaac atttctcttg ctaagaccat
     6241 gaaaacatca tgatttaata catctaaagt attcgagaaa atcaataact catagtaccc
     6301 ccagtattct acactaaaga gataatctgt taaatatgtc aaatcatcct ttgtatagta
     6361 agtttctcct gataaatcct gtagacgaat tttcaataaa ataatattga tttgatgaaa
     6421 tttttctcgc ctatcttcca gttccatctg agaataaagt aattttttca taccttctac
     6481 gtcacgtgtt gacacaaaat gacgtacttt cgataacagt tcgtttaact catctctatg
     6541 aaaatcatgg accgcataca taaattcatc tattggcata ttgatttcat ctaaaataaa
     6601 catgaacttt gaaatcgtta aatctgtttc tcctttctca aatcgagaga gctgagacgt
     6661 tgatatacca gcctttgcga cgtcttttaa tcgtaatcct ctcgattctc gaaacttttt
     6721 aaaaatttct ccaaattttt tcatactaca cctccatcac gcatatatgg gaataatttt
     6781 catttgcttt catcatatca tacaataaag aaaaacaaaa gtgaggatta tcacatgaaa
     6841 aagcaaattt tactaacact tcttcttgtc gtatttgaag gcattatcgt tatcgtcgtg
     6901 ggataaagag tctgggacaa aagtccttta gctccaaaaa gcaacggcat aatgtactga
     6961 ccccaaaaag ttagacaaat aatttaagta aaggatttag ttctgtattg tacaggactg
     7021 agtcctttta gttttacctt aatgcgtttg ttgttgtaat aattaatata gtctgcaatt
     7081 gcttgttcca aatgctcaat tgacttaaac gtcttctcat aacaataaaa catctcagac
     7141 ttaagaatgc caaagaagga ttccatcatg ccgttgtctg gactattgcc tttacgtgac
     7201 atggatggtt ggattccttt ctcctctaaa aaatgatgat agaaatcatg ttgatattgc
     7261 catccctggt cactatggag aattgtattt ttgtaatgtt tctctgtaaa ggcttgttct
     7321 aacatagctt tcacttgtat caagttcggt gacttagaaa gattgtaggc gataatttca
     7381 ctattgaagc catctaaaat tggcgacaaa tagagttttt ggctgcttgc tggaatggca
     7441 aattctgtta catctgtgta gcatttttcc aatggtttgg atgcttcgaa ctggcgttgg
     7501 atgagattct ctgctttcat accaacctct ccttgatatg aagaatactt acgtttacgg
     7561 cgaattctag cggttaaacc aagtactttc ataagacgtt gaactctctt atgattaatc
     7621 acaattcctc gatttctcaa ttcaagagtc attcgacgat agccgtaatt tcctttatgc
     7681 tcagtaaaaa tggcttgaat ttcagcttta atgtcataat ccttatcatt ttgatccagc
     7741 tgttttaagt ggtaataata ggttgaacga gcaagcttaa taatctttag aagcatatct
     7801 aaagaaaact cagttaccaa tcctcggaca atttccgttt ttcttcttgc tctttttctt
     7861 ccctcaatcg gagttctctc aactttttaa gaactgcatt ctccgctcta aggtactcat
     7921 tttctgcttg aagacgttcc atttcttcca gttttttctt tggcttacgt cccattttag
     7981 ataaccttcc tcttgttttc tcaacaatag tacccgtttt tcttatagtg tgcgagccag
     8041 ttaggaagcg tcccacgatt tgggagagca tattcaagag aaactctatc ttgagaatag
     8101 cctttatata ggactttatc aatcatttct tgttttaatt caggagagta gtaacgattc
     8161 tttccttttt tagcgatttc tattccgtat cgatcaatca atttaatcat gtagctaaga
     8221 ttagaaatgt ttatcccaaa tttatttgaa agctgatcta agctatatcc ttggtttcta
     8281 agttcataga tttgaacctt atcttcataa gtcaatttca taataaaaac accccgaaag
     8341 ttagattttt tctgtctaac ttttggggtg cagttcataa aaccgttgct ttttgcatga
     8401 ttgtgataga cttggtgaaa tagaattgac caaaaatctt ctgaaatata acaagagagt
     8461 gactcgaatt taaaaagcta gagttccaca attggaaatc tctagctttt ttgtgactga
     8521 gaactttttg tcccagcctc tactttctac tgactactat cctgcatgcc ctaagtcgag
     8581 atagagaata tctcgcttag tggcatactc tagcgcatgt tcaacagcct caaataaatc
     8641 tgaagctaga aaccttttcg taaagacggt ttcgtcttta cgcttaaatt tcgcaacata
     8701 actatgttta gtcatttttt ctccttctaa tattcatatt gtcctttaac accactatag
     8761 atccagtaaa ctgctttatc ataaacttgt ttaaaggaga tacctaatcg attggctaca
     8821 tcaagaattg aaatttgctt acattcctct atattcataa aatatcatca ttttgtcgta
     8881 gtattcggca atgatggaac agatgaggat tcttctaaag ttttaggagt tgccttatct
     8941 agatcatcta acccagattt ccaaacctgt acttggttga ccaataactt accaggtagt
     9001 ttcgaatagt tcaaattaac cgttctggtt tctgtttggt ttgtctttga ttggttggca
     9061 ttctttaaat cagatacata agttacatta taagagacca tggcaatggc ttgattcgta
     9121 gtctgattga caaagatatc tgctttttca aaatgataat ccaaaatata gtccttatac
     9181 acttggttca tggcatcatt ttgacttgtc aattcttgag aataggccga ttcagtcata
     9241 taaggttgaa tacgtgtatt attttcccct agtttttctt tcgtatagta ctgtgtcaaa
     9301 aattctttta cagtatctga tgataaaata cttgctttat cttctgcttg tttgtcctct
     9361 acaagtttag ctgcagccaa ttcgatttct tttcgacttt gtttggcagt agaatgttga
     9421 ccaatagaat tagcagtaag ttgtggtgtt gatgaggtgg atatactaaa aaatgaggag
     9481 gaaattgata atgacttcac ctagctaaaa gttcaacgaa ttagggagac attaggtagc
     9541 ctcatattac cttgattagt ttttgctata acattgtcaa atatgatgac aaaaaaatcc
     9601 gtccgcactt ttttacgagt aggacgaatt aaatatgtta tacaaaccat cagcttttta
     9661 acaattctac ataaggtagt tgttaatgca actacctttt ttctatgttg attagaacaa
     9721 atttgacatg gctacaactg cgattatctg atatagagta ttatataaac tgattcctcc
     9781 taccccttat ccacaatttt aatacggcta ctgccatcgt gcgacttgat gataactagt
     9841 tgctgagcaa taccttcttt catatcgtcc acgtggctga tgacaccgac catgcgattt
     9901 tcaccgattt gttctaggac agagatagcc ttagtgaggg cttccttatc aagtgaaccg
     9961 aaaccttcgt cgatgaagag tgcttcaaca acggcaccct tgctggtatt ttggacaact
    10021 tctgagaggg atagggcaat ggccagtgca gcgataaagg tttcaccacc agacaaggat
    10081 ttaacggagc gttcactacc tgtcagctgg tcatagacgt tgatatccaa accgaagtga
    10141 tcacgcgccc tgcgtccttc ctcacttaga acaaaggaat agcggttatc cgttaatagt
    10201 ccgatgtagt tagcattggc atagtccaag atttgttgga aatactgacg gataacgtag
    10261 acctcaagat taagacgacc agttagagca gtattttctc ccttaaccac cttaaccaaa
    10321 tcactgagtt cttggtgggc cttaaaggcc tcttggttgc tgtcttgaag ggttttagcc
    10381 gcttggtagg tagccgtcgc atccttaagt cccttttcca tgacagaaaa ctgagcgagc
    10441 tgcctatcat agatttcctg acaattctgt actgcttgcg ctagactatc gagatctggt
    10501 tgttcttgat tttggagaag ctcttgcccc ttacgaatct gcgcctgtaa ttcttgtttg
    10561 agcgttgcat aggtcgttaa tttggcctga agcataggaa tagcttgatt atttacctca
    10621 ataagccaga gttcgacctg ctctaagtca ttggcgaggg ctccttcagc cttgagactt
    10681 tgctctaatt cagcagataa tcgcttaaca tcttgattta ccttatcttt agacttagtt
    10741 atactctcaa tctgcccctt gattccttta atgtcggcat gaagttggtt gtaggcttcg
    10801 ctattttcct tgacttgctt attgtagagg ttcagctcct gatgagcaag ggaaatccgt
    10861 tcttgatata cctcaacaga ctcaagttct ggatgagctt cctgcaagtc ctctaggcgt
    10921 tcttgagctt ggtcaagcac tgccttggcc tcttgatagg ttttagccaa atctgtcgct
    10981 tttttttgag ccttacctag ctcatcttga tatcggatat aatctgtctc ttccttatca
    11041 taacgttttt gtaactcttg ataatactgc tcaaccttca ggagtagggc ttgcccacgg
    11101 tcagtttcat agtctatcga aaaatcaaaa tcaaaccgtc ccttaacgtg ctcttctaat
    11161 tcttgatagt gcttttcaag agttgccttg actttagtca cttggtcaag caaatcctga
    11221 cgtttagatg caacttcact caaggtagcc tgacgatttg ataaagtagc gacttgcttt
    11281 tctttttgag cttgaagctt ctccacctga tccatgagat ttttcaaggc cacttcatca
    11341 gcctgtgctc caccaacatt agggtgttcc agagcaccac aaaccataca aggatgcccc
    11401 tcctctaact ctgcctgcag ttggacaatc atgagttgac ggcgtgaaac caaagtcctt
    11461 cttaactcct cttccaattc tttgagaatt tcttgagctt gatcaatatc aaaagataac
    11521 gtttgatgac gtttttcggt ctttgtcaac tcctgattca agttctctat ctctttcagg
    11581 tcctgagcaa gttgattctc cacactgtag cccacaatct ggaagagttt ttcggcctca
    11641 tgtaaactct ctaaactaag acgattagcc tccaagtcag acaaggactt gttaagcatc
    11701 tcaacctctt ttctagcctg ctgataggtc tcttccaact gcttgtagtt agtcgttgaa
    11761 cgtttgattt tctcctgttc ttgggcaaga ctctgggaat agataatatc ctctttccaa
    11821 gtttcaagct cctcttcttt ttgaagaaaa tcctcagatt gaattgcgag ttcctctttt
    11881 ttagccttaa catcctcaaa cgcctgttgc ttttcactta aggcttcttg agcaatttca
    11941 aggtcctgct ctaattgcat caactgtttc cgatactgct tcaaggtccg aatggtttcc
    12001 tgcagacctt gagcaaactg taattcctcc agatgcactt ttgcctctgc ctgtccttga
    12061 gccccctcct caatttccag acggtaacgt tccttggctt gctccaattc ttgaaaaatc
    12121 tttgccaaat cttgggcagt ttggaagctc ttctgcagtt gtgccaaatc ctcgtgggca
    12181 gccttcaaga tacttttttg ctccgtaaga ctttcttgac gctgagacaa aaactcttca
    12241 agacgtgcca atttttcaga ggctggcgtt gacgccaaga cagctaattc ttcctccgac
    12301 caaacctgac tggcaaagtg gctatctatc tgagcctgac gcttatccat atccttattg
    12361 ctctgacgaa gacgctcttc caaactcttt tgaaaacggt caaagatacc tgtcccaaag
    12421 attttcttta aaatttgagt cttagtcttg gaatcttcct tcaaaaaacg gctaaaatca
    12481 ttttgcggta agaggataat ctgtttgaac tgctcagcat tgagccccaa aatctgctca
    12541 atctggtcac tcacttcctt gatcttatcc ccaagctttt caatttcctg accaccaatc
    12601 ttatccacaa tgactagaga agccgtcgcc ttttgcatgg tagtgccccc accctgcttg
    12661 gccctctctt gctggagaac tcggtcaatg cgataaaggt gattgccttg ttggaaatag
    12721 aaagtcacct tggtcaaatc atcctctgga ccagcgaaag ttgaccgcat ctcctcaaca
    12781 ttacgatcac cactggtcgt agcaaacaag gctaccgtca tggcatcaaa gagagtactc
    12841 ttaccagccc ctgtatcccc tccaatcaaa aagaggggag catggtcaaa ctgagtgaaa
    12901 ttaataactt ccttacgata tggtccaaaa ttggtcaatt ctaactggac tggtctcatt
    12961 gtcgactcct ctcaatctcc tcaaaaacac tttccacaag ggcagtctgt ctctcagata
    13021 agacatcgcc cccagttact gtctggtaaa aatcaaatac gatttcctgg ggcgactgca
    13081 tttccaaatc ttttaagtgc tgatcaacgg tcaagttttc ttccctaaca tcacccagac
    13141 gactgaaagt aatttctaca atgtctgtcc cataaatctc ttccagtcgg gcacgcacat
    13201 tgataccctc taattcctta cgactagaca gttgaatatc aaaggcgaac caggcttttt
    13261 gacaaggttg attcttataa aattcaggtg acatcaaggt ttcaaaagat tcctgtaaag
    13321 ccacaatcgg ccgtttaacc tctagagtat ggaaggtctg agacatatca ccagacgcat
    13381 ccaattcaag aatatagaca cccttttctt ccttacgctt ggcttctttg acattaaagg
    13441 cgactggact gcctgaatat tgcacgcgct tggtaggact agcaaaacgc gtatggatat
    13501 gccctaaggc aacataatcg aaagacttga aaaggtcact ggtcacattg gtaagaccac
    13561 ctaccgtatt actggtttca gacaacatca attctcgaag accctgacca tcgctatcat
    13621 ccttcttaga aaccgcaaaa tgcgtcacca agacatgagc tttgtcagga tcaaaagctt
    13681 tttccatatc ctcaagaatg taggtcaagg catcaccaat cccctgaatt tcctttccct
    13741 catcatcctt atagtaaata cgagcatcaa taggatcgat aaaaggcagc agaaaaatct
    13801 ggcaattctc caactcaatg ggctcaaaag cctcctccaa acgtgtactt aaatgaaggc
    13861 cctgatgttg aaagaagtca cgcccaaaat gtaaacgttc agccccatcg tgattaccac
    13921 taatcgcata gacaggaatc tgctcctcca gtaccaagcg ggccaaggtc ttattaaaaa
    13981 gcttaatcgc atccacaggg ggcaccgcac ggtcatagag gtccccagaa atgataaccc
    14041 catccacttt ttcgctaata gccaaatcca caatttgttg aaaagcccac tcctgctcct
    14101 ccaacaaaga ccagccattg agggttcgtc ctacatgcca atctgacgta tgtaaaaact
    14161 tcatgacaac ctcctcattc attttgtctt acttctattg taccttatca agctaaatac
    14221 tgcttaaaag tttcacaggc tttgatagtt ttcccgtttt ttagctgtaa agatcaaaaa
    14281 atctctccca agctatcctg tactgacccc aaaaagttag acaatttatg taagcaaagg
    14341 atttagctct gtattgcaca ggattgagtc cttttagttt taccttaatg catttgttgt
    14401 tgtagtaatc aatatagtct agattaccct gcctcaattg gttaagtaat ttaaatacct
    14461 ctaaccaaga aaatcaatat tatctattct tttaattgac ttttatagat tctaagcatt
    14521 atcatatagg ttggtactag tgcacatctt gtattttagg caataatatt tactcacttt
    14581 tcgttattgt cagtaccgat cctttttaaa tttttcacca tgaaaaccta aaaataatcc
    14641 gaaccctaag ggctcctgac tttttacttt attctaggct ttttttatcc gtagcttgtt
    14701 agctgacttg gaactaggca tgtagtattt actatttccc tacttgagat tttttataag
    14761 tcacatgcat tattccatct gaacgaatgg tatgattttt atttctttta gagaaacacc
    14821 ggtaatagct aattcctatc ttaaatcact tgaaatatat ttataatgtg ttggagtgct
    14881 aatcagtacc gcttgtagat ttttggaaga tactaacaca ctaatgattt aatctccttt
    14941 aaaacatgaa aagagaagcc tccaaagctt ctcttttata attatcaaat aatgtacaac
    15001 tagattctta ataactacct aatttagtgg ttcaatcatg aagcttaatt gatagctatc
    15061 tgctgagcta agcaagaatt cgtcatgaac tggagcaccc catgtgtcgt caccacctac
    15121 acccatttga gcagcaagaa ctttaatcca tgtagcatca gattcttgca actcatattg
    15181 gtgacgagca ttttcaattt gttcagtact gttacgcaaa gcactgaatt cgaatgcttt
    15241 attaagtgcg gtgaatttaa gaccattatg gttatcatca gatactgtga attcacgagt
    15301 accatagtga ttaccagatt cttgtggcat tagatatgga gcaaatgtct tttcaacaga
    15361 tgtttcatat cgaccaagat aggcaccagg aagtttatca cggtagcttt cttctgcacc
    15421 gtatccataa tagctaaggt ttgtaaattg tgaaccgata gcaaattcta gaccaaattc
    15481 agggaagttt ggcaaacctg ctttaccatc atagtttgca gtaacaaaga ttcgaccctt
    15541 gtaatcaact tgataagtta ccttaacttc gacatcagac aagcctggca attcatgaac
    15601 ataagtcact ttaacagagt cgtcttcgat ttgaatttga gtatctgtaa ctttactata
    15661 gtttccagca accttccagc ctgccatttc gaatggatat ccagcaccac gatcgttgtc
    15721 agtgtaagca cgagtgaagc taagtttagg acctttctca atgaattcaa caccattata
    15781 cttagcagat actaaagtat tttgtgcacg tgaaagcaag attgagaagt tttgtccttg
    15841 aataccgatg ttgaagtcgc cttcaacaac attcaaaggt gctttaactg gtgtttcagt
    15901 gctaatcttt tcaacaacat attgaccacg aacaatttca tgacctttag gagcccattc
    15961 agttgcttcc ctcagaacac aagcaacttc gtaaatttgt tcagaatttg aagcctcgac
    16021 tacaaagtta actgggaatg ttgcttcttc gcctggttta acatcaaagt gatattcact
    16081 ttcactaact tttctaccat cttcgtaaac tctagctagg aaagtataag cagaaagatc
    16141 ttcgaagaga ttatcattct tgatagttac tgatttttca tcaacagcaa tcttaatatt
    16201 agagtaaaga tgtttaactg tttgaagttt tggagttagg gtacgatctg caaagacgat
    16261 accatttcca caaaattcgt agtcagaagg tctatcatgc cagtcaccac catatgatag
    16321 gaattcgcta ccatttggaa gtgttttgta aatagcttgg tcaatgaagt cccaaataaa
    16381 tccaccttgg tattctggat atttctctaa gtcagtgtag agttgcaatc caccaccaga
    16441 gttacccatt gtgtgcatgt attcacatga aatataaggt ttttgaggtt tgttagttag
    16501 gttacctgaa gcaaagtgtt tatcactaac gcttgaaaga tcaactagtt taccagttgt
    16561 gaggtattct tcgatatcag ctggtttcgc atacatacga ctttcgatgt ctgtaatgta
    16621 atcaaactca cgacaccatg caacaccttc atagtgaact ggacgagtat tgtcaacact
    16681 acggaagtaa tcagccatgt cagcaatatc tttaccagca tatgattcat taccacaaga
    16741 ccaa
//
