LOCUS       gnlProkkaICPEPJGA_49   17611 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ICPEPJGA_49.
ACCESSION   gnlProkkaICPEPJGA_49
VERSION     gnlProkkaICPEPJGA_49
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:54:32
            Original ID  :: gnl|Prokka|ICPEPJGA_49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17611
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17611
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5186:7611]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5187..7611
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17611
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17611
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             3..605
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 179.1; E-value:
                     1.8e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg39_1"
                     /transl_table=11
                     /translation="MINFEAESGQLILVVGPSGSGKTTFLTIAGGLQTPTNGDVKINDS
                     TINSLSKKQQTKLRLEKIGFVLQSYNLVPFLTVEEQFKFVDKLKKQNLTEQKLHELLSD
                     LGLLELLKKYPNQLSGGQKQRVAIARALYTDPDYILADEPTAALDTDRSMKVIELLRDL
                     AHKRNKIIIVVTHDFRLKDMADKVYQIIDGKMTILEK"
     CDS             1077..1178
                     /locus_tag="ctg39_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             1348..1617
                     /locus_tag="ctg39_3"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1777..2076
                     /locus_tag="ctg39_4"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(2176..3087)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg39_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(3317..3406)
                     /locus_tag="ctg39_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(3403..4005)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALKLDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(4099..5190)
                     /locus_tag="ctg39_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(5187..6506)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_9"
                     /sec_met_domain="Streptide_RRE (E-value: 9.3e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6576..6668)
                     /locus_tag="ctg39_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6751..7611)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg39_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7851..8687)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg39_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8681..9247)
                     /locus_tag="ctg39_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(9426..9584)
                     /locus_tag="ctg39_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9596..9727)
                     /locus_tag="ctg39_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9905..10369)
                     /locus_tag="ctg39_16"
                     /transl_table=11
                     /translation="MKSLSISSSFFSISTSSTPQLTANSIGQHSTAKQSRKEIELAAAK
                     LVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQNDAM
                     NQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTN"
     CDS             complement(10649..13828)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 496.3; E-value: 3.2e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg39_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDRFQKSLEERLRQSNKDMDKRQAQIDSHFASQVWSE
                     EELTVLASTPASEKLARLEEFLSQRQESLTEQKSILKAAHEDLAQLQKSFQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELAIQSEDFLQKEEELETWKEDIIYSQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLESLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLMIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVTKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13825..15033)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.9; E-value: 5.9e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg39_18"
                     /sec_met_domain="Metallophos_2 (E-value: 5.5e-10, bitscore:
                     31.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMKKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 aaaatattaa tttcgaagca gaaagcggtc agcttatttt agttgtaggg ccatcaggat
       61 caggaaaaac tacatttttg actatagcag gcggactaca gacaccaact aatggtgacg
      121 taaaaataaa tgacagtaca attaacagtt tgtccaaaaa acaacaaaca aaattaagat
      181 tggaaaaaat aggatttgtt ttacaatctt ataacttagt cccattttta acggtcgaag
      241 aacagtttaa attcgtagat aaactaaaaa aacaaaattt gactgaacaa aaattgcatg
      301 agcttctttc tgatttagga cttttagaac tgctaaaaaa atatcctaat caactttctg
      361 gtggacaaaa gcagcgtgtg gcaattgcta gagcattata cactgatcct gactatattt
      421 tagcagatga acccacagcc gcattagata cagatagatc catgaaagta atcgagttac
      481 tcagagattt agcgcacaaa agaaataaaa ttattattgt agttactcat gactttaggt
      541 taaaagatat ggcagacaaa gtttatcaga taattgacgg taaaatgaca atcctggaga
      601 agtaatttaa tttatgacta aaaatcagca aaaatataat tatgactaag gaatatatta
      661 ttaactaaat gttgagatag cacaaggaaa tatttgtgct atctttttta tttattagga
      721 aaagagaaaa aattatgcca acgaaaatat ggttaaaacc agaacaatta gatttgtata
      781 ttaaacattt agaacgattt agagacttat atagtaaact agactgttct ggtatagtaa
      841 atttgtaaca ctcctaccta ataagttaaa ctattcatta gaataggaga cataacatga
      901 aacactatcc agacgaaaca cgataaaaaa ttgttcgact gcacattcaa gacggatgaa
      961 cattaaaaag cttagctgct gaatatggcg tatcccaagc ctcaatctct aattgggtaa
     1021 gacattatcg caaagaatgc caaactaata ataaagaaaa atcacagctt gaactcatgg
     1081 aggaggttcg taaattacgt caagaaaagg cagagcttga aaaggaaaat gatttcttaa
     1141 aaaaagcagc ggcattcttt gcaaaggaaa tcgattagag gcatatcgtt ttattgataa
     1201 ctataaagaa gattttggtt tgcgttggtt gttcttgcat atgaatattc atcccaatgc
     1261 ttattataat tatcttaaaa agacaaggac taactatcat cgtcaaaaga aagctattct
     1321 taatactatt cgagatatct accatgagtg caatggaaag aagtaaatca attcttcgaa
     1381 acagaaagca tcaaactttc tgatatagag ccttcgaaag ttagttatag ggaggtacaa
     1441 aggaatcaaa tcaataccac tatttataat gaaaaaggta atataaagga tattgatact
     1501 agcattataa gagatatgta cgataaaagc aaacctactt taaaacaggg agcctatata
     1561 tccgctatag cagcttctct agaagggggg tactgcattt ataacagcaa taattaaaaa
     1621 aagcgcttag ggaaaactat tagtgagttt acaaaagacg attgtcttga aatttctaaa
     1681 gatagtggaa ttggagctat aaaaggaagt actcgaggca ttacgatata cgccctaacg
     1741 aattacacag ctactcctgc agcagtagca agttcattgt gcactgcttc atttggtatc
     1801 gctaaagaag catacaaatt ccgtaaaaac ttaatcacaa aagaagaatt tttactaaat
     1861 tcgcaaatat tatgtgttga agtatcagtt agtgcattat cctcaatatt aggacatgct
     1921 gtaattccaa tacctatttt aggatccgtt attggaaata atataggaac tttcctatat
     1981 gaaatcgcta aagataatct cacaatgaaa gagaaattac tgatagcaga ttatttcaaa
     2041 gagatacaag aatataacta ttttttagat aattaatttg aattatataa tcatcaactt
     2101 cagagagatt aagaattact ataaactttt agggaaggca ttttctcctg actataatat
     2161 cgcttttcag ggatcttatg aatttttaaa tatgtttttt aaaaatacgt taacctctcc
     2221 tattttctct gcttcaggta aatagataga aacggttgtc gaataaacaa aagaaggtac
     2281 actcacaatt gaaagcaatt gactaataac tgcataaata gccaacaatt ctactcctaa
     2341 tctcgacatc aaggcatcaa acaccataat aaacaaaaca ctctccagaa tttcttgacc
     2401 aaccaaagga ataccaaatg ttattaattc aaatttagtt gtagatgtaa tggataaagc
     2461 cttcaaaatc attggataaa ccataaacaa gtaactaagc gatatgaaag ctaaggatac
     2521 aatcgttgat atggctgctc ccttaattcc gatttgtggt accagtacat aatttaacac
     2581 aacatctatt aatgaactga taagtccaac ccacataatt ggttttgttt tcttttgaac
     2641 tcttaataaa tttgtcagcg aaaagtttaa taatgtcaat ccgatatatg gagacatgaa
     2701 gactaaataa atggtggata aggacaatag ttgcccttta aatccataga gctgcttcaa
     2761 gattacattt ccaaaaataa tgacaaaaac cgcaaaggca actccgataa ttaaatctaa
     2821 ggttagattt gatttcaata aatcatcaaa cctgttagtt tgccgattag agtacgcctt
     2881 agagctttta atattaaatg acaaactgaa tgctcctaaa agtccaccaa aagcaaataa
     2941 gagattctga ataatggaaa ttcctgacag agcaattgag gaattgttca cagcaaaatg
     3001 caatgctatc tgcccaataa ttacttgacc aatatttgtt aaaactaagg gaaaggcaaa
     3061 tttgttaatt tcttttgaat ctatcatttt tcctctctaa aaggcttcaa atgtaagtaa
     3121 agatcagatt taactaaatt tgcataaata atatgcaaaa taggagtttc ttctaaaaat
     3181 gaaataattg cctgcttaca atcattagca gatacctcat aatcttgctg taatagttct
     3241 acaatcttgt ctaaagaaaa atttttagaa atgcaataaa gtatttctgc tcctatttca
     3301 tcaaatgaat agtactctaa tcaagtagat cgtatcctat gtattcatct gctactttat
     3361 ttacaatgaa atctctctta cctcttatca caaaatgttc tttcatacga ctactccacc
     3421 tcctttttgt tcataaaagc aggctaaatc agagcccagt aacgttccat ctaatttcaa
     3481 ggcactgcat cgacatcccc caccacacca tggtagggga cattctgaac atttcccaga
     3541 aatatcatca aatgtaattg atcttagttt attaaataca gcagaatggt gccaaatttc
     3601 gctaaacttt tgttctttaa catttccagc aactaattca tctataccat tcatcaagtc
     3661 acacccgtat acatctcctt tatgattaat tgaacatgct ctaactccag cttgacaaga
     3721 tatttccctt ggcttatcaa aatttatatc tactttttga tgccaaacat tttctaataa
     3781 atctgatcta ttataaaatg caagcggaaa ataatgtgtc aaaaaaacat cactttcatt
     3841 aggaggaaca attttaaatt taactttgaa ctctccttta gaaatccgct ctgttaaatc
     3901 aagaaaaaca ggataccatt gttttttatc tgctaaaata ctaccgtcat tagccctacc
     3961 agtaggacaa ataaccataa ctgacatata ctcaatacca agcatatcat tcaatcttat
     4021 actctaaaga aaatatctgc taaatttgca aacaattgtg ctatcaataa tttggcaaat
     4081 gaattagaaa tacaactttt aagttctttt ctctctgtta gaaaatgaat aagatactaa
     4141 gcaacaaaga gctactatac caaatattaa ataattgctc ctaatactaa agttatcagc
     4201 aaaaatacca gctaggaaat cagctaacat aaaactaatc gaaataaaca aattatatac
     4261 tgaccatgat actgctctat ttttttctat tgacatatta aatttataat aaaaatgatt
     4321 attgtagttg gaattaagaa cacgcattaa taaaaggatt ataatttgga tgattagatt
     4381 agtttgaaaa aacatgagta tagctaatac tggtaacatc aagcttactt caaacttaat
     4441 ttttagataa ctccccaaag ccatagatat attaaacata aatagtataa ttcccagcat
     4501 atctagtgaa agtccctgtt catttaagaa tatccctgca taagaattgc taatcataat
     4561 tagagttgag aatgctactc ctaatattat taataaccat ggaatatttt gaatattatc
     4621 gaggctaaaa aatttttgtt tattattttg ttccttttta atctcgggta atcctattaa
     4681 atataataaa ctgaaaatta caaatacaat ggatataata ataggataaa tataattcct
     4741 atgcaataaa ggtggagata taatcgtaat aatagcaata aaaatatatt ttaatgtgtt
     4801 gagatttttc aaaaatgatt tatatacaac ttcgtcatca attatttcaa aattataaga
     4861 aataagaact cctgaagata atgattctga caatccaaaa aatatcgctg aaatatatat
     4921 tatatttgat tttccaaaca ataggcccca taatgctaaa attaataata aatttgaaat
     4981 agccaaaatt ttcttgtaac caatcttact tgaaatataa cttaaaggaa tatcaaaaac
     5041 tgagccacat agctcagtaa taactgataa agtagctatt tctgtgaacg aaaaacctaa
     5101 gtgctttaat agtaaaattc ctacaaagta gtacggtaat ccagatagaa acatattcat
     5161 tccgtataaa ttaaaaatct tcttactcat aagttacaaa ctgggtctct aaaatatttt
     5221 ggactcttct ccttaatcaa gttaacatag cagccaccct cgcaaatttt taacaatcca
     5281 caagataaac acttagaatt cttcgttcta aaagaacgaa tccctccata caacggatca
     5341 tcataccaaa catctaacaa atctttttca aaggcattct gcttagtttg attaactcct
     5401 aaaaaagcaa tgcaaggcaa gatatcccca ttagacatta tttccatctt agtatatttt
     5461 gcacgacatc cataatacat ttcgccaaac tctgaaaatt caattgaatt atttatcaac
     5521 tccggataag cggtgaaaag atgacatccc tcagtagcaa aatttaaatt agcttcccgt
     5581 tgagttatat aatctgtaac atactcattc aaccttctca aatcagctaa atcgtatttt
     5641 ttctttattt tcgtatatcc tgttacctca gaataattag ctactgaaaa tctatctatt
     5701 ttattctcta tacaaaaatc aaccaattct ataatctgct catagctttg ctttgtatac
     5761 actgcattaa ttctacattt ttttccaacc tctttaaagt acttcgctaa tttaatttgt
     5821 ctatcaggtc tcacccccat taattcaaaa tttaatttag gatctaaagt ctgcaaagat
     5881 aaaaccggtg taatatattt agatttagct agaatttcca ctgtactttt ctttattaat
     5941 tgggcattag ttgttatagt agtctttatc ttcagttctt cacaagctat caacaaatta
     6001 tcaatatcaa aatatctagt cggttcccct cctaaaattg aaacacttaa cactccatta
     6061 tcttttgctt ggcgcaaaat tctttcccaa tctttagcag gtttggcatt tctatcttca
     6121 cgatttgcta aaaaacaaaa accacatttt aaatcacagt acatactggg gtatattact
     6181 agttcaagcg gaaaactcaa tatgttatgt ttttttaatt ttgctacatg ctttctcgca
     6241 ttttgaagag tctcgtcagg atttttcgat gatccctcaa tattattatc agaatagata
     6301 tttaataaga gtactcgctc tagtttccct gcttttattt ctttcttaaa aaaggacgta
     6361 gcaatttcaa aaccatgatt ttgaaccaaa taaagaaaat aagcttcact ctcatctaac
     6421 tcaattcggt caaaagttac tttatttatc aaaattccac caaacttttc tagtctaaat
     6481 aaaaaatctt ctgaaattgt catcatattg aatacctttc taaaaaagca gaggaaaata
     6541 tagcctctgc ttaacttatg ggataaatta ctttatcact cccagccgtc accttttgcc
     6601 atcaccttcc agccgtcacc ttttgccatt gaactagact caaggacttt ttcaagctct
     6661 ttagacatat ttggtactcc tttcgaatat gatactgtga ttatatttct tttcaacact
     6721 tacaataaaa tattcccata tttgcatttt ctaactacta gctaaaattt tttctaaatg
     6781 tccttcataa gtctttgcta agtgatgact tcctgctaat ttcatcgctc caacacactt
     6841 cttcatttca ataattgctt tcacatttcc atcctcttta tattgataaa gattttgtgc
     6901 atacttaaag actaaacgtt catatacttc tgtctcaata aaaaagcatt gatttagctg
     6961 cttttcaaaa tataaagcat ccataaattt ttctctttca acacatgtaa tatatccatt
     7021 taaaagcatc gttgaaatta atcgtctgtt atttggaatt tctttgtaaa aatcagaacg
     7081 cctaaacatt tctcttgcta agaccatgaa aacatcatga tttaatacat ctaaagtatt
     7141 cgagaaaatc aataactcat agtaccccca gtattctaca ctaaagagat aatctgttaa
     7201 atatgtcaaa tcatcctttg tatagtaagt ttctcctgat aaatcctgta gacgaatttt
     7261 caataaaata atattgattt gatgaaattt ttctcgccta tcttccagtt ccatctgaga
     7321 ataaagtaat tttttcatac cttctacgtc acgtgttgac acaaaatgac gtactttcga
     7381 taacagttcg tttaactcat ctctatgaaa atcatggacc gcatacataa attcatctat
     7441 tggcatattg atttcatcta aaataaacat gaactttgaa atcgttaaat ctgtttctcc
     7501 tttctcaaat cgagagagct gagacgttga tataccagcc tttgcgacgt cttttaatcg
     7561 taatcctctc gattctcgaa actttttaaa aatttctcca aattttttca tactacacct
     7621 ccatcacgca tatatgggaa taattttcat ttgctttcat catatcatac aataaagaaa
     7681 aacaaaagtg aggattatca catgaaaaag caaattttac taacacttct tcttgtcgta
     7741 tttgaaggca ttatcgttat cgtcgtggga taaagagtct gggacaaaag tcctttagct
     7801 ccaaaaagca acggcataat gtactgaccc caaaaagtta gacaaataat ttaagtaaag
     7861 gatttagttc tgtattgtac aggactgagt ccttttagtt ttaccttaat gcgtttgttg
     7921 ttgtaataat taatatagtc tgcaattgct tgttccaaat gctcaattga cttaaacgtc
     7981 ttctcataac cataaaacat ctcagactta agaatgccaa agaaggattc catcatgccg
     8041 ttgtctggac tattgccttt acgtgacatg gatggttgga ttcctttctc ctctaaaaaa
     8101 tgatgataga aatcatgttg atattgccat ccctggtcac tatggagaat tgtatttttg
     8161 taatgtttct ctgtaaaggc ttgttctaac atagctttca cttgtatcaa gttcggtgac
     8221 ttagaaagat tgtaggcgat aatttcacta ttgaagccat ctaaaattgg cgacaaatag
     8281 agtttttggc tgcttgctgg aatggcaaat tctgttacat ctgtgtagca tttttccaat
     8341 ggtttggatg cttcgaactg gcgttggatg agattctctg ctttcatacc aacctctcct
     8401 tgatatgaag aatacttacg tttacggcga attctagcgg ttaaaccaag tactttcata
     8461 agacgttgaa ctctcttatg attaatcaca attcctcgat ttctcaattc aagagtcatt
     8521 cgacgatagc cgtaatttcc tttatgctca gtaaaaatgg cttgaatttc agctttaatg
     8581 tcataatcct tatcattttg atccagctgt tttaagtggt aataataggt tgaacgagca
     8641 agcttaataa tctttagaag catatctaaa gaaaactcag ttaccaatcc tcggacaatt
     8701 tccgtttttc ttcttgctct ttttcttccc tcaatcggag ttctctcaac tttttaagaa
     8761 ctgcattctc cgctctaagg tactcatttt ctgcttgaag acgttccatt tcttccagtt
     8821 ttttctttgg cttacgtccc attttagata accttcctct tgttttctca acaatagtat
     8881 acccgttttt cttatagtgt gcgagccagt taggaagcgt cccacgattt gggagagcat
     8941 attcaagaga aactctatct tgagaatagc ctttatatag gactttatca atcatttctt
     9001 gttttaattc aggagagtag taacgattct ttcctttttt agcgatttct attccgtatc
     9061 gatcaatcaa tttaatcatg tagctaagat tagaaatgtt tatcccaaat ttatttgaaa
     9121 gctgatctaa gctatatcct tggtttctaa gttcatagat ttgaacctta tcttcataag
     9181 tcaatttcat aataaaaaca ccccgaaagt tagatttttt ctgtctaact tttggggtgc
     9241 agttcataaa accgttgctt tttgcatgat tgtgatagac ttggtgaaat agaattgacc
     9301 aaaaatcttc tgaaatataa caagagagtg actcgaattt aaaaagctag agttccacaa
     9361 ttggaaatct ctagcttttt tgtgactgag aactttttgt cccagcctct actttctact
     9421 gactactatc ctgcatgccc taagtcgaga tagagaatat ctcgcttagt ggcatactct
     9481 agcgcatgtt caacagcctc aaataaatct gaagctagaa accttttcgt aaagacggtt
     9541 tcgtctttac gcttaaattt cgcaacataa ctatgtttag tcattttttc tccttctaat
     9601 attcatattg tcctttaaca ccactataga tccagtaaac tgctttatca taaacttgtt
     9661 taaaggagat acctaatcga ttggctacat caagaattga aatttgctta cattcctcta
     9721 tattcataaa atatcatcat tttgtcgtag tattcggcaa tgatggaaca gatgaggatt
     9781 cttctaaagt tttaggagtt gccttatcta gatcatctaa cccagatttc caaacctgta
     9841 cttggttgac caataactta ccaggtagtt tcgaatagtt caaattaacc gttctggttt
     9901 ctgtttagtt tgtctttgat tggttggcat tctttaaatc agatacataa gttacattat
     9961 aagagaccat ggcaatggct tgattcgtag tctgattgac aaagatatct gctttttcaa
    10021 aatgataatc caaaatatag tccttataca cttggttcat ggcatcattt tgacttgtca
    10081 attcttgaga ataggccgat tcagtcatat aaggttgaat acgtgtatta ttttccccta
    10141 gtttttcttt cgtatagtac tgtgtcaaaa attcttttac agtatctgat gataaaatac
    10201 ttgctttatc ttctgcttgt ttgtcctcta caagtttagc tgcagccaat tcgatttctt
    10261 ttcgactttg tttggcagta gaatgttgac caatagaatt agcagtaagt tgtggtgttg
    10321 atgaggtgga tatactaaaa aatgaggagg aaattgataa tgacttcacc tagctaaaag
    10381 ttcaacgaat tagggagaca ttaggtagcc tcatattacc ttgattagtt tttgctataa
    10441 cattgtcaaa tatgatgaca aaaaaatccg tccgcacttt tttacgagta ggacgaatta
    10501 aatatgttat acaaaccatc agctttttaa caattctaca taaggtagtt gttaatgcaa
    10561 ctaccttttt tctatgttga ttagaacaaa tttgacatgg ctacaactgc gattatctga
    10621 tatagagtat tatataaact gattcctcct accccttatc cacaatttta atacggctac
    10681 tgccatcgtg cgacttgatg ataactagtt gctgagcaat accttctttc atatcgtcca
    10741 cgtggctgat gacaccgacc atgcgatttt caccgatttg ttctaggaca gagatagcct
    10801 tagtgagggc ttccttatca agtgaaccga aaccttcgtc gatgaagagt gcttcaacaa
    10861 cggcaccctt gctggtattt tggacaactt ctgagaggga tagggcaatg gccagtgcag
    10921 cgataaaggt ttcaccacca gacaaggatt taacggagcg ttcactacct gtcagctggt
    10981 catagacgtt gatatccaaa ccgaagtgat cacgcgccct gcgtccttcc tcacttagaa
    11041 caaaggaata gcggttatcc gttaatagtc cgatgtagtt agcattggca tagtccaaga
    11101 tttgttggaa atactgacgg ataacgtaga cctcaagatt aagacgacca gttagagcag
    11161 tattttctcc cttaaccacc ttaaccaaat cactgagttc ttggtgggcc ttaaaggcct
    11221 cttggttgct gtcttgaagg gttttagccg cttggtaggt agccgtcgca tccttaagtc
    11281 ccttttccat gacagaaaac tgagcgagct gcctatcata gatttcctga caattctgta
    11341 ctgcttgcgc tagactatcg agatctggtt gttcttgatt ttggagaagc tcttgcccct
    11401 tacgaatctg cgcctgtaat tcttgtttga gcgttgcata ggtcgttaat ttggcctgaa
    11461 gcataggaat agcttgatta tttacctcaa taagccagag ttcgacctgc tctaagtcat
    11521 tggcgagggc tccttcagcc ttgagacttt gctctaattc agcagataat cgcttaacat
    11581 cttgatttac cttatcttta gacttagtta tactctcaat ctgccccttg attcctttaa
    11641 tgtcggcatg aagttggttg taggcttcgc tattttcctt gacttgctta ttgtagaggt
    11701 tcagctcctg atgagcaagg gaaatccgtt cttgatatac ctcaacagac tcaagttctg
    11761 gatgagcttc ctgcaagtcc tctaggcgtt cttgagcttg gtcaagcact gccttggcct
    11821 cttgataggt tttagccaaa tctgtcgctt ttttttgagc cttacctagc tcatcttgat
    11881 atcggatata atctgtctct tccttatcat aacgtttttg taactcttga taatactgct
    11941 caaccttcag gagtagggct tgcccacggt cagtttcata gtctatcgaa aaatcaaaat
    12001 caaaccgtcc cttaacgtgc tcttctaatt cttgatagtg cttttcaaga gttgccttga
    12061 ctttagtcac ttggtcaagc aaatcctgac gtttagatgc aacttcactc aaggtagcct
    12121 gacgatttga taaagtagcg acttgctttt ctttttgagc ttgaagcttc tccacctgat
    12181 ccatgagatt tttcaaggcc acttcatcag cctgtgctcc accaacatta gggtgttcca
    12241 gagcaccaca aaccatacaa ggatgcccct cctctaactc tgcctgcagt tggacaatca
    12301 tgagttgacg gcgtgaaacc aaagtccttc ttaactcctc ttccaattct ttgagaattt
    12361 cttgagcttg atcaatatca aaagataacg tttgatgacg tttttcggtc tttgtcaact
    12421 cctgattcaa gttctctatc tctttcaggt cctgagcaag ttgattctcc acactgtagc
    12481 ccacaatctg gaagagtttt tcggcctcat gtaaactctc taaactaaga cgattagcct
    12541 ccaagtcaga caaggacttg ttaagcatct caacctcttt tctagcctgc tgataggtct
    12601 cttccaactg cttgtagtta gtcgttgaac gtttgatttt ctcctgttct tgggcaagac
    12661 tctgggaata gataatatcc tctttccaag tttcaagctc ctcttctttt tgaagaaaat
    12721 cctcagattg aattgcgagt tcctcttttt tagccttaac atcctcaaac gcctgttgct
    12781 tttcacttaa ggcttcttga gcaatttcaa ggtcctgctc taattgcatc aactgtttcc
    12841 gatactgctt caaggtccga atggtttcct gcagaccttg agcaaactgt aattcctcca
    12901 gatgcacttt tgcctctgcc tgtccttgag ccccctcctc aatttccaga cggtaacgtt
    12961 ccttggcttg ctccaattct tgaaaaatct ttgccaaatc ttgggcagtt tggaagctct
    13021 tctgcagttg tgccaaatcc tcgtgggcag ccttcaagat acttttttgc tccgtaagac
    13081 tttcttgacg ctgagacaaa aactcttcaa gacgtgccaa tttttcagag gctggcgttg
    13141 acgccaagac agttaattct tcctccgacc aaacctgact ggcaaagtgg ctatctatct
    13201 gagcctgacg cttatccata tccttattgc tctgacgaag acgctcttcc aaactctttt
    13261 gaaaacggtc aaagatacct gtcccaaaga ttttctttaa aatttgagtc ttagtcttgg
    13321 aatcttcctt caaaaaacgg ctaaaatcat tttgcggtaa gaggataatc tgtttgaact
    13381 gctcagcatt gagccccaaa atctgctcaa tctggtcact cacttccttg atcttatccc
    13441 caagcttttc aatttcctga ccaccaatct tatccacaat gactagagaa gccgtcgcct
    13501 tttgcatggt agtgccccca ccctgcttgg ccctctcttg ctggagaact cggtcaatgc
    13561 gataaaggtg attgccttgt tggaaataga aagtcacctt ggtcaaatca tcctctggac
    13621 cagcgaaagt tgaccgcatc tcctcaacat tacgatcacc actggtcgta gcaaacaagg
    13681 ctaccgtcat ggcatcaaag agagtactct taccagcccc tgtatcccct ccaatcaaaa
    13741 agaggggagc atggtcaaac tgagtgaaat taataacttc cttacgatat ggtccaaaat
    13801 tggtcaattc taactggact ggtctcattg tcgactcctc tcaatctcct caaaaacact
    13861 ttccacaagg gcagtctgtc tctcagataa gacatcgccc ccagttactg tctggtaaaa
    13921 atcaaatacg atttcctggg gcgactgcat ttccaaatct tttaagtgct gatcaacggt
    13981 caagttttct tccctaacat cacccagacg actgaaagta atttctacaa tgtctgtccc
    14041 ataaatctct tccagtcggg cacgcacatt gataccctct aattccttac gactagacag
    14101 ttgaatatca aaggcgaacc aggctttttg acaaggttga ttcttataaa attcaggtga
    14161 catcaaggtt tcaaaagatt cctgtaaagc cacaatcggc cgtttaacct ctagagtatg
    14221 gaaggtctga gacatatcac cagacgcatc caattcaaga atatagacac ccttttcttc
    14281 cttacgcttg gcttctttga cattaaaggc gactggactg cctgaatatt gcacgcgctt
    14341 ggtaggacta gcaaaacgcg tatggatatg ccctaaggca acataatcga aagacttgaa
    14401 aaggtcactg gtcacattgg taagaccacc taccgtatta ctggtttcag acaacatcaa
    14461 ttctcgaaga ccctgaccat cgctatcatc cttcttagaa accgcaaaat gcgtcaccaa
    14521 gacatgagct ttgtcaggat caaaagcttt tttcatatcc tcaagaatgt aggtcaaggc
    14581 atcaccaatc ccctgaattt cctttccctc atcatcctta tagtaaatac gagcatcaat
    14641 aggatcgata aaaggcagca gaaaaatctg gcaattctcc aactcaatgg gctcaaaagc
    14701 ctcctccaaa cgtgtactta aatgaaggcc ctgatgttga aagaagtcac gcccaaaatg
    14761 taaacgttca gccccatcgt gattaccact aatcgcatag acaggaatct gctcctccag
    14821 taccaagcgg gccaaggtct tattaaaaag cttaatcgca tccacagggg gcaccgcacg
    14881 gtcatagagg tccccagaaa tgataacccc atccactttt tcgctaatag ccaaatccac
    14941 aatttgttga aaagcccact cctgctcctc caacaaagac cagccattga gggttcgtcc
    15001 tacatgccaa tctgacgtat gtaaaaactt catgacaacc tcctcattca ttttgtctta
    15061 cttctattgt accttatcaa gctaaatact gcttaaaagt ttcacaggct ttgatagttt
    15121 tcccgttttt tagctgtaaa gatcaaaaaa tctctcccaa gctatcctgt actgacccca
    15181 aaaagttaga caatttatgt aagcaaagga tttagctctg tattgcacag gattgagtcc
    15241 ttttagtttt accttaatgc atttgttgtt gtagtaatca atatagtcta gattaccctg
    15301 cctcaattgg ttaagtaatt taaatacctc taaccaagaa aatcaatatt atctattctt
    15361 ttaattgact tttatagatt ctaagcatta tcatataggt tggtactagt gcacatcttg
    15421 tattttaggc aataatattt actcactttt cgttattgtc agtaccgatc ctttttaaat
    15481 ttttcaccat gaaaacctaa aaataatccg aaccctaagg gctcctgact ttttacttta
    15541 ttctaggctt tttttatccg tagcttgtta gctgacttgg aactaggcat gtagtattta
    15601 ctatttccct acttgagatt ttttataagt cacatgcatt attccatctg aacgaatggt
    15661 atgattttta tttcttttag agaaacaccg gtaatagcta attcctatct taaatcactt
    15721 gaaatatatt tataatgtgt tggagtgcta atcagtaccg cttgtagatt tttggaagat
    15781 actaacacac taatgattta atctccttta aaacatgaaa agagaagcct ccaaagcttc
    15841 tcttttataa ttatcaaata atgtacaact agattcttaa taactaccta atttagtggt
    15901 tcaatcatga agcttaattg atagctatct gctgagctaa gcaagaattc gtcatgaact
    15961 ggagcacccc atgtgtcgtc accacctaca cccatttgag cagcaagaac tttaatccat
    16021 gtagcatcag attcttgcaa ctcatattgg tgacgagcat tttcaatttg ttcagtactg
    16081 ttacgcaaag cactgaattc gaatgcttta ttaagtgcgg tgaatttaag accattatgg
    16141 ttatcatcag atactgtgaa ttcacgagta ccatagtgat taccagattc ttgtggcatt
    16201 agatatggag caaatgtctt ttcaacagat gtttcatatc gaccaagata ggcaccagga
    16261 agtttatcac ggtagctttc ttctgcaccg tatccataat agctaaggtt tgtaaattgt
    16321 gaaccgatag caaattctag accaaattca gggaagtttg gcaaacctgc tttaccatca
    16381 tagtttgcag taacaaagat tcgacccttg taatcaactt gataagttac cttaacttcg
    16441 acatcagaca agcctggcaa ttcatgaaca taagtcactt taacagagtc gtcttcgatt
    16501 tgaatttgag tatctgtaac tttactatag tttccagcaa ccttccagcc tgccatttcg
    16561 aatggatatc cagcaccacg atcgttgtca gtgtaagcac gagtgaagct aagtttagga
    16621 cctttctcaa tgaattcaac accattatac ttagcagata ctaaagtatt ttgtgcacgt
    16681 gaaagcaaga ttgagaagtt ttgtccttga ataccgatgt tgaagtcgcc ttcaacaaca
    16741 ttcaaaggtg ctttaactgg tgtttcagtg ctaatctttt caacaacata ttgaccacga
    16801 acaatttcat gacctttagg agcccattca gttgcttccc tcagaacaca agcaacttcg
    16861 taaatttgtt cagaatttga agcctcgact acaaagttaa ctgggaatgt tgcttcttcg
    16921 cctggtttaa catcaaagtg atattcactt tcactaactt ttctaccatc ttcgtaaact
    16981 ctagctagga aagtataagc agaaagatct tcgaagagat tatcattctt gatagttact
    17041 gatttttcat caacagcaat cttaatatta gagtaaagat gtttaactgt ttgaagtttt
    17101 ggagttaggg tacgatctgc aaagacgata ccatttccac aaaattcgta gtcagaaggt
    17161 ctatcatgcc agtcaccacc atatgatagg aattcgctac catttggaag tgttttgtaa
    17221 atagcttggt caatgaagtc ccaaataaat ccaccttggt attctggata tttctctaag
    17281 tcagtgtaga gttgcaatcc accaccagag ttacccattg tgtgcatgta ttcacatgaa
    17341 atataaggtt tttgaggttt gttagttagg ttacctgaag caaagtgttt atcactaacg
    17401 cttgaaagat caactagttt accagttgtg aggtattctt cgatatcagc tggtttcgca
    17461 tacatacgac tttcgatgtc tgtaatgtaa tcaaactcac gacaccatgc aacaccttca
    17521 tagtgaactg gacgagtatt gtcaacacta cggaagtaat cagccatgtc agcaatatct
    17581 ttaccagcat atgattcatt accacaagac c
//
