LOCUS       gnlProkkaMEBJBEIB_62   17131 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MEBJBEIB_62.
ACCESSION   gnlProkkaMEBJBEIB_62
VERSION     gnlProkkaMEBJBEIB_62
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 13:04:40
            Original ID  :: gnl|Prokka|MEBJBEIB_62
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17131
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17131
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4706:7131]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4707..7131
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..17131
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17131
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             3..125
                     /locus_tag="ctg50_1"
                     /transl_table=11
                     /translation="MDLAHKRNKIIIVVTHDLRLKDMADKVYQIIDGKMTILEK"
     CDS             597..698
                     /locus_tag="ctg50_2"
                     /transl_table=11
                     /translation="MEEVRKLRQEKAELEKENDFLKKAAAFFAKEID"
     CDS             868..1137
                     /locus_tag="ctg50_3"
                     /transl_table=11
                     /translation="MQWKEVNQFFETESIKLSDIEPSKVSYREVQRNQINTTIYNEKGN
                     IKDIDTSIIRDMYDKSKPTLKQGAYISAIAASLEGGYCIYNSNN"
     CDS             1297..1596
                     /locus_tag="ctg50_4"
                     /transl_table=11
                     /translation="MCTASFGIAKEAYKFRKNLITKEEFLLNSQILCVEVSVSALSSIL
                     GHAVIPIPILGSVIGNNIGTFLYEIAKDNLTMKEKLLIADYFKEIQEYNYFLDN"
     CDS             complement(1696..2607)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 99; E-value: 4.5e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg50_5"
                     /transl_table=11
                     /translation="MIDSKEINKFAFPLVLTNIGQVIIGQIALHFAVNNSSIALSGISI
                     IQNLLFAFGGLLGAFSLSFNIKSSKAYSNRQTNRFDDLLKSNLTLDLIIGVAFAVFVII
                     FGNVILKQLYGFKGQLLSLSTIYLVFMSPYIGLTLLNFSLTNLLRVQKKTKPIMWVGLI
                     SSLIDVVLNYVLVPQIGIKGAAISTIVSLAFISLSYLFMVYPMILKALSITSTTKFELI
                     TFGIPLVGQEILESVLFIMVFDALMSRLGVELLAIYAVISQLLSIVSVPSFVYSTTVSI
                     YLPEAEKIGEVNVFLKNIFKNS"
     CDS             complement(2837..2926)
                     /locus_tag="ctg50_6"
                     /transl_table=11
                     /translation="MKEHFVIRGKRDFIVNKVADEYIGYDLLD"
     CDS             complement(2923..3525)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_7"
                     /sec_met_domain="TIGR04085 (E-value: 1.1e-15, bitscore:
                     49.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.2e-13, bitscore: 41.9,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGIEYMSVMVICPTGRANDGSILADKKQWYPVFLDLTERISKGE
                     FKVKFKIVPPNESDVFLTHYFPLAFYNRSDLLENVWHQKVDINFDKPREISCQAGVRAC
                     SINHKGDVYGCDLMNGIDELVAGNVKEQKFSEIWHHSAVFNKLRSITFDDISGKCSECP
                     LPWCGGGCRCSALKLDGTLLGSDLACFYEQKGGGVVV"
     CDS             complement(3619..4710)
                     /locus_tag="ctg50_8"
                     /transl_table=11
                     /translation="MSKKIFNLYGMNMFLSGLPYYFVGILLLKHLGFSFTEIATLSVIT
                     ELCGSVFDIPLSYISSKIGYKKILAISNLLLILALWGLLFGKSNIIYISAIFFGLSESL
                     SSGVLISYNFEIIDDEVVYKSFLKNLNTLKYIFIAIITIISPPLLHRNYIYPIIISIVF
                     VIFSLLYLIGLPEIKKEQNNKQKFFSLDNIQNIPWLLIILGVAFSTLIMISNSYAGIFL
                     NEQGLSLDMLGIILFMFNISMALGSYLKIKFEVSLMLPVLAILMFFQTNLIIQIIILLL
                     MRVLNSNYNNHFYYKFNMSIEKNRAVSWSVYNLFISISFMLADFLAGIFADNFSIRSNY
                     LIFGIVALCCLVSYSFSNREKRT"
     CDS             complement(4707..6026)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_9"
                     /sec_met_domain="Streptide_RRE (E-value: 9.3e-25, bitscore:
                     79.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.6e-20, bitscore: 64.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.5e-07, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-13, bitscore:
                     43.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTISEDFLFRLEKFGGILINKVTFDRIELDESEAYFLYLVQNHG
                     FEIATSFFKKEIKAGKLERVLLLNIYSDNNIEGSSKNPDETLQNARKHVAKLKKHNILS
                     FPLELVIYPSMYCDLKCGFCFLANREDRNAKPAKDWERILRQAKDNGVLSVSILGGEPT
                     RYFDIDNLLIACEELKIKTTITTNAQLIKKSTVEILAKSKYITPVLSLQTLDPKLNFEL
                     MGVRPDRQIKLAKYFKEVGKKCRINAVYTKQSYEQIIELVDFCIENKIDRFSVANYSEV
                     TGYTKIKKKYDLADLRRLNEYVTDYITQREANLNFATEGCHLFTAYPELINNSIEFSEF
                     GEMYYGCRAKYTKMEIMSNGDILPCIAFLGVNQTKQNAFEKDLLDVWYDDPLYGGIRSF
                     RTKNSKCLSCGLLKICEGGCYVNLIKEKSPKYFRDPVCNL"
     CDS             complement(6096..6188)
                     /locus_tag="ctg50_10"
                     /transl_table=11
                     /translation="MSKELEKVLESSSMAKGDGWKVMAKGDGWE"
     CDS             complement(6271..7131)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_11"
                     /sec_met_domain="TIGR01716 (E-value: 4.7e-51, bitscore:
                     165.4, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKFGEIFKKFRESRGLRLKDVAKAGISTSQLSRFEKGETDLTIS
                     KFMFILDEINMPIDEFMYAVHDFHRDELNELLSKVRHFVSTRDVEGMKKLLYSQMELED
                     RREKFHQINIILLKIRLQDLSGETYYTKDDLTYLTDYLFSVEYWGYYELLIFSNTLDVL
                     NHDVFMVLAREMFRRSDFYKEIPNNRRLISTMLLNGYITCVEREKFMDALYFEKQLNQC
                     FFIETEVYERLVFKYAQNLYQYKEDGNVKAIIEMKKCVGAMKLAGSHHLAKTYEGHLEK
                     ILASS"
     CDS             complement(7371..8207)
                     /gene_functions="other (smcogs) SMCOG1026:transposase
                     (Score: 266.7; E-value: 3.2e-81)"
                     /gene_kind="other"
                     /locus_tag="ctg50_12"
                     /transl_table=11
                     /translation="MVTEFSLDMLLKIIKLARSTYYYHLKQLDQNDKDYDIKAEIQAIF
                     TEHKGNYGYRRMTLELRNRGIVINHKRVQRLMKVLGLTARIRRKRKYSSYQGEVGMKAE
                     NLIQRQFEASKPLEKCYTDVTEFAIPASSQKLYLSPILDGFNSEIIAYNLSKSPNLIQV
                     KAMLEQAFTEKHYKNTILHSDQGWQYQHDFYHHFLEEKGIQPSMSRKGNSPDNGMMESF
                     FGILKSEMFYGYEKTFKSIEHLEQAIADYINYYNNKRIKVKLKGLSPVQYRTKSFT"
     CDS             complement(8201..8767)
                     /locus_tag="ctg50_13"
                     /transl_table=11
                     /translation="MNCTPKVRQKKSNFRGVFIMKLTYEDKVQIYELRNQGYSLDQLSN
                     KFGINISNLSYMIKLIDRYGIEIAKKGKNRYYSPELKQEMIDKVLYKGYSQDRVSLEYA
                     LPNRGTLPNWLAHYKKNGYTIVEKTRGRLSKMGRKPKKKLEEMERLQAENEYLRAENAV
                     LKKLRELRLREEKEQEEKRKLSEDW"
     CDS             complement(8946..9104)
                     /locus_tag="ctg50_14"
                     /transl_table=11
                     /translation="MTKHSYVAKFKRKDETVFTKRFLASDLFEAVEHALEYATKRDILY
                     LDLGHAG"
     CDS             complement(9116..9247)
                     /locus_tag="ctg50_15"
                     /transl_table=11
                     /translation="MNIEECKQISILDVANRLGISFKQVYDKAVYWIYSGVKGQYEY"
     CDS             complement(9425..9889)
                     /locus_tag="ctg50_16"
                     /transl_table=11
                     /translation="MKSLSISSSFFSISTSSTPQLTANSIGQHSTAKQSRKEIELAAAK
                     LVEDKQAEDKASILSSDTVKEFLTQYYTKEKLGENNTRIQPYMTESAYSQELTSQNDAM
                     NQVYKDYILDYHFEKADIFVNQTTNQAIAMVSYNVTYVSDLKNANQSKTN"
     CDS             complement(10169..13348)
                     /gene_functions="other (smcogs) SMCOG1218:Exonuclease
                     (Score: 496.3; E-value: 3.2e-150)"
                     /gene_kind="other"
                     /locus_tag="ctg50_17"
                     /transl_table=11
                     /translation="MRPVQLELTNFGPYRKEVINFTQFDHAPLFLIGGDTGAGKSTLFD
                     AMTVALFATTSGDRNVEEMRSTFAGPEDDLTKVTFYFQQGNHLYRIDRVLQQERAKQGG
                     GTTMQKATASLVIVDKIGGQEIEKLGDKIKEVSDQIEQILGLNAEQFKQIILLPQNDFS
                     RFLKEDSKTKTQILKKIFGTGIFDRFQKSLEERLRQSNKDMDKRQAQIDSHFASQVWSE
                     EELTVLASTPASEKLARLEEFLSQRQESLTEQKSILKAAHEDLAQLQKSFQTAQDLAKI
                     FQELEQAKERYRLEIEEGAQGQAEAKVHLEELQFAQGLQETIRTLKQYRKQLMQLEQDL
                     EIAQEALSEKQQAFEDVKAKKEELAIQSEDFLQKEEELETWKEDIIYSQSLAQEQEKIK
                     RSTTNYKQLEETYQQARKEVEMLNKSLSDLEANRLSLESLHEAEKLFQIVGYSVENQLA
                     QDLKEIENLNQELTKTEKRHQTLSFDIDQAQEILKELEEELRRTLVSRRQLMIVQLQAE
                     LEEGHPCMVCGALEHPNVGGAQADEVALKNLMDQVEKLQAQKEKQVATLSNRQATLSEV
                     ASKRQDLLDQVTKVKATLEKHYQELEEHVKGRFDFDFSIDYETDRGQALLLKVEQYYQE
                     LQKRYDKEETDYIRYQDELGKAQKKATDLAKTYQEAKAVLDQAQERLEDLQEAHPELES
                     VEVYQERISLAHQELNLYNKQVKENSEAYNQLHADIKGIKGQIESITKSKDKVNQDVKR
                     LSAELEQSLKAEGALANDLEQVELWLIEVNNQAIPMLQAKLTTYATLKQELQAQIRKGQ
                     ELLQNQEQPDLDSLAQAVQNCQEIYDRQLAQFSVMEKGLKDATATYQAAKTLQDSNQEA
                     FKAHQELSDLVKVVKGENTALTGRLNLEVYVIRQYFQQILDYANANYIGLLTDNRYSFV
                     LSEEGRRARDHFGLDINVYDQLTGSERSVKSLSGGETFIAALAIALSLSEVVQNTSKGA
                     VVEALFIDEGFGSLDKEALTKAISVLEQIGENRMVGVISHVDDMKEGIAQQLVIIKSHD
                     GSSRIKIVDKG"
     CDS             complement(13345..14553)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_functions="other (smcogs) SMCOG1230:Nuclease SbcCD, D
                     subunit (Score: 253.9; E-value: 5.9e-77)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_18"
                     /sec_met_domain="Metallophos_2 (E-value: 5.5e-10, bitscore:
                     31.4, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFLHTSDWHVGRTLNGWSLLEEQEWAFQQIVDLAISEKVDGVII
                     SGDLYDRAVPPVDAIKLFNKTLARLVLEEQIPVYAISGNHDGAERLHFGRDFFQHQGLH
                     LSTRLEEAFEPIELENCQIFLLPFIDPIDARIYYKDDEGKEIQGIGDALTYILEDMKKA
                     FDPDKAHVLVTHFAVSKKDDSDGQGLRELMLSETSNTVGGLTNVTSDLFKSFDYVALGH
                     IHTRFASPTKRVQYSGSPVAFNVKEAKRKEEKGVYILELDASGDMSQTFHTLEVKRPIV
                     ALQESFETLMSPEFYKNQPCQKAWFAFDIQLSSRKELEGINVRARLEEIYGTDIVEITF
                     SRLGDVREENLTVDQHLKDLEMQSPQEIVFDFYQTVTGGDVLSERQTALVESVFEEIER
                     SRQ"
ORIGIN
        1 tcagagattt agcgcacaaa agaaataaaa ttattattgt agttactcat gacttaaggt
       61 taaaagatat ggcagacaaa gtttatcaga taattgacgg taaaatgaca atcctggaga
      121 agtaatttaa tttatgacta aaaatcagca aaaatataat tatgactaag gaatatatta
      181 ttaactaaat gttgagatag cacaaggaaa tatttgtgct atctttttta tttattagga
      241 aaagagaaaa aattatgcca acgaaaatat ggttaaaacc agaacaatta gatttgtata
      301 ttaaacattt agaacgattt agagacttat atagtaaact agactgttct ggtatagtaa
      361 atttgtaaca ctcctaccta ataagttaaa ctattcatta gaataggaga cataacatga
      421 aacactatcc agacgaaaca cgataaaaaa ttgttcgact gcacattcaa gacggatgaa
      481 cattaaaaag cttagctgct gaatatggcg tatcccaagc ctcaatctct aattgggtaa
      541 gacattatcg caaagaatgc caaactaata ataaagaaaa atcacagctt gaactcatgg
      601 aggaggttcg taaattacgt caagaaaagg cagagcttga aaaggaaaat gatttcttaa
      661 aaaaagcagc ggcattcttt gcaaaggaaa tcgattagag gcatatcgtt ttattgataa
      721 ctataaagaa gattttggtt tgcgttggtt gttcttgcat atgaatattc atcccaatgc
      781 ttattataat tatcttaaaa agacaaggac taactatcat cgtcaaaaga aagctattct
      841 taatactatt cgagatatct accatgagtg caatggaaag aagtaaatca attcttcgaa
      901 acagaaagca tcaaactttc tgatatagag ccttcgaaag ttagttatag ggaggtacaa
      961 aggaatcaaa tcaataccac tatttataat gaaaaaggta atataaagga tattgatact
     1021 agcattataa gagatatgta cgataaaagc aaacctactt taaaacaggg agcctatata
     1081 tccgctatag cagcttctct agaagggggg tactgcattt ataacagcaa taattaaaaa
     1141 aagcgcttag ggaaaactat tagtgagttt acaaaagacg attgtcttga aatttctaaa
     1201 gatagtggaa ttggagctat aaaaggaagt actcgaggca ttacgatata cgccctaacg
     1261 aattacacag ctactcctgc agcagtagca agttcattgt gcactgcttc atttggtatc
     1321 gctaaagaag catacaaatt ccgtaaaaac ttaatcacaa aagaagaatt tttactaaat
     1381 tcgcaaatat tatgtgttga agtatcagtt agtgcattat cctcaatatt aggacatgct
     1441 gtaattccaa tacctatttt aggatccgtt attggaaata atataggaac tttcctatat
     1501 gaaatcgcta aagataatct cacaatgaaa gagaaattac tgatagcaga ttatttcaaa
     1561 gagatacaag aatataacta ttttttagat aattaatttg aattatataa tcatcaactt
     1621 cagagagatt aagaattact ataaactttt agggaaggca ttttctcctg actataatat
     1681 cgcttttcag ggatcttatg aatttttaaa tatgtttttt aaaaatacgt taacctctcc
     1741 tattttctct gcttcaggta aatagataga aacggttgtc gaataaacaa aagaaggtac
     1801 actcacaatt gaaagcaatt gactaataac tgcataaata gccaacaatt ctactcctaa
     1861 tctcgacatc aaggcatcaa acaccataat aaacaaaaca ctctccagaa tttcttgacc
     1921 aaccaaagga ataccaaatg ttattaattc aaatttagtt gtagatgtaa tggataaagc
     1981 cttcaaaatc attggataaa ccataaacaa gtaactaagc gatatgaaag ctaaggatac
     2041 aatcgttgat atggctgctc ccttaattcc gatttgtggt accagtacat aatttaacac
     2101 aacatctatt aatgaactga taagtccaac ccacataatt ggttttgttt tcttttgaac
     2161 tcttaataaa tttgtcagcg aaaagtttaa taatgtcaat ccgatatatg gagacatgaa
     2221 gactaaataa atggtggata aggacaatag ttgcccttta aatccataga gctgcttcaa
     2281 gattacattt ccaaaaataa tgacaaaaac cgcaaaggca actccgataa ttaaatctaa
     2341 ggttagattt gatttcaata aatcatcaaa cctgttagtt tgccgattag agtacgcctt
     2401 agagctttta atattaaatg acaaactgaa tgctcctaaa agtccaccaa aagcaaataa
     2461 gagattctga ataatggaaa ttcctgacag agcaattgag gaattgttca cagcaaaatg
     2521 caatgctatc tgcccaataa ttacttgacc aatatttgtt aaaactaagg gaaaggcaaa
     2581 tttgttaatt tcttttgaat ctatcatttt tcctctctaa aaggcttcaa atgtaagtaa
     2641 agatcagatt taactaaatt tgcataaata atatgcaaaa taggagtttc ttctaaaaat
     2701 gaaataattg cctgcttaca atcattagca gatacctcat aatcttgctg taatagttct
     2761 acaatcttgt ctaaagaaaa atttttagaa atgcaataaa gtatttctgc tcctatttca
     2821 tcaaatgaat agtactctaa tcaagtagat cgtatcctat gtattcatct gctactttat
     2881 ttacaatgaa atctctctta cctcttatca caaaatgttc tttcatacga ctactccacc
     2941 tcctttttgt tcataaaagc aggctaaatc agagcccagt aacgttccat ctaatttcaa
     3001 ggcactgcat cgacatcccc caccacacca tggtagggga cattctgaac atttcccaga
     3061 aatatcatca aatgtaattg atcttagttt attaaataca gcagaatggt gccaaatttc
     3121 gctaaacttt tgttctttaa catttccagc aactaattca tctataccat tcatcaagtc
     3181 acacccgtat acatctcctt tatgattaat tgaacatgct ctaactccag cttgacaaga
     3241 tatttccctt ggcttatcaa aatttatatc tactttttga tgccaaacat tttctaataa
     3301 atctgatcta ttataaaatg caagcggaaa ataatgtgtc aaaaaaacat cactttcatt
     3361 aggaggaaca attttaaatt taactttgaa ctctccttta gaaatccgct ctgttaaatc
     3421 aagaaaaaca ggataccatt gttttttatc tgctaaaata ctaccgtcat tagccctacc
     3481 agtaggacaa ataaccataa ctgacatata ctcaatacca agcatatcat tcaatcttat
     3541 actctaaaga aaatatctgc taaatttgca aacaattgtg ctatcaataa tttggcaaat
     3601 gaattagaaa tacaactttt aagttctttt ctctctgtta gaaaatgaat aagatactaa
     3661 gcaacaaaga gctactatac caaatattaa ataattgctc ctaatactaa agttatcagc
     3721 aaaaatacca gctaggaaat cagctaacat aaaactaatc gaaataaaca aattatatac
     3781 tgaccatgat actgctctat ttttttctat tgacatatta aatttataat aaaaatgatt
     3841 attgtagttg gaattaagaa cacgcattaa taaaaggatt ataatttgga tgattagatt
     3901 agtttgaaaa aacatgagta tagctaatac tggtaacatc aagcttactt caaacttaat
     3961 ttttagataa ctccccaaag ccatagatat attaaacata aatagtataa ttcccagcat
     4021 atctagtgaa agtccctgtt catttaagaa tatccctgca taagaattgc taatcataat
     4081 tagagttgag aatgctactc ctaatattat taataaccat ggaatatttt gaatattatc
     4141 gaggctaaaa aatttttgtt tattattttg ttccttttta atctcgggta atcctattaa
     4201 atataataaa ctgaaaatta caaatacaat ggatataata ataggataaa tataattcct
     4261 atgcaataaa ggtggagata taatcgtaat aatagcaata aaaatatatt ttaatgtgtt
     4321 gagatttttc aaaaatgatt tatatacaac ttcgtcatca attatttcaa aattataaga
     4381 aataagaact cctgaagata atgattctga caatccaaaa aatatcgctg aaatatatat
     4441 tatatttgat tttccaaaca ataggcccca taatgctaaa attaataata aatttgaaat
     4501 agccaaaatt ttcttgtaac caatcttact tgaaatataa cttaaaggaa tatcaaaaac
     4561 tgagccacat agctcagtaa taactgataa agtagctatt tctgtgaacg aaaaacctaa
     4621 gtgctttaat agtaaaattc ctacaaagta gtacggtaat ccagatagaa acatattcat
     4681 tccgtataaa ttaaaaatct tcttactcat aagttacaaa ctgggtctct aaaatatttt
     4741 ggactcttct ccttaatcaa gttaacatag cagccaccct cgcaaatttt taacaatcca
     4801 caagataaac acttagaatt cttcgttcta aaagaacgaa tccctccata caacggatca
     4861 tcataccaaa catctaacaa atctttttca aaggcattct gcttagtttg attaactcct
     4921 aaaaaagcaa tgcaaggcaa gatatcccca ttagacatta tttccatctt agtatatttt
     4981 gcacgacatc cataatacat ttcgccaaac tctgaaaatt caattgaatt atttatcaac
     5041 tccggataag cggtgaaaag atgacatccc tcagtagcaa aatttaaatt agcttcccgt
     5101 tgagttatat aatctgtaac atactcattc aaccttctca aatcagctaa atcgtatttt
     5161 ttctttattt tcgtatatcc tgttacctca gaataattag ctactgaaaa tctatctatt
     5221 ttattctcta tacaaaaatc aaccaattct ataatctgct catagctttg ctttgtatac
     5281 actgcattaa ttctacattt ttttccaacc tctttaaagt acttcgctaa tttaatttgt
     5341 ctatcaggtc tcacccccat taattcaaaa tttaatttag gatctaaagt ctgcaaagat
     5401 aaaaccggtg taatatattt agatttagct agaatttcca ctgtactttt ctttattaat
     5461 tgggcattag ttgttatagt agtctttatc ttcagttctt cacaagctat caacaaatta
     5521 tcaatatcaa aatatctagt cggttcccct cctaaaattg aaacacttaa cactccatta
     5581 tcttttgctt ggcgcaaaat tctttcccaa tctttagcag gtttggcatt tctatcttca
     5641 cgatttgcta aaaaacaaaa accacatttt aaatcacagt acatactggg gtatattact
     5701 agttcaagcg gaaaactcaa tatgttatgt ttttttaatt ttgctacatg ctttctcgca
     5761 ttttgaagag tctcgtcagg atttttcgat gatccctcaa tattattatc agaatagata
     5821 tttaataaga gtactcgctc tagtttccct gcttttattt ctttcttaaa aaaggacgta
     5881 gcaatttcaa aaccatgatt ttgaaccaaa taaagaaaat aagcttcact ctcatctaac
     5941 tcaattcggt caaaagttac tttatttatc aaaattccac caaacttttc tagtctaaat
     6001 aaaaaatctt ctgaaattgt catcatattg aatacctttc taaaaaagca gaggaaaata
     6061 tagcctctgc ttaacttatg ggataaatta ctttatcact cccagccgtc accttttgcc
     6121 atcaccttcc agccgtcacc ttttgccatt gaactagact caaggacttt ttcaagctct
     6181 ttagacatat ttggtactcc tttcgaatat gatactgtga ttatatttct tttcaacact
     6241 tacaataaaa tattcccata tttgcatttt ctaactacta gctaaaattt tttctaaatg
     6301 tccttcataa gtctttgcta agtgatgact tcctgctaat ttcatcgctc caacacactt
     6361 cttcatttca ataattgctt tcacatttcc atcctcttta tattgataaa gattttgtgc
     6421 atacttaaag actaaacgtt catatacttc tgtctcaata aaaaagcatt gatttagctg
     6481 cttttcaaaa tataaagcat ccataaattt ttctctttca acacatgtaa tatatccatt
     6541 taaaagcatc gttgaaatta atcgtctgtt atttggaatt tctttgtaaa aatcagaacg
     6601 cctaaacatt tctcttgcta agaccatgaa aacatcatga tttaatacat ctaaagtatt
     6661 cgagaaaatc aataactcat agtaccccca gtattctaca ctaaagagat aatctgttaa
     6721 atatgtcaaa tcatcctttg tatagtaagt ttctcctgat aaatcctgta gacgaatttt
     6781 caataaaata atattgattt gatgaaattt ttctcgccta tcttccagtt ccatctgaga
     6841 ataaagtaat tttttcatac cttctacgtc acgtgttgac acaaaatgac gtactttcga
     6901 taacagttcg tttaactcat ctctatgaaa atcatggacc gcatacataa attcatctat
     6961 tggcatattg atttcatcta aaataaacat gaactttgaa atcgttaaat ctgtttctcc
     7021 tttctcaaat cgagagagct gagacgttga tataccagcc tttgcgacgt cttttaatcg
     7081 taatcctctc gattctcgaa actttttaaa aatttctcca aattttttca tactacacct
     7141 ccatcacgca tatatgggaa taattttcat ttgctttcat catatcatac aataaagaaa
     7201 aacaaaagtg aggattatca catgaaaaag caaattttac taacacttct tcttgtcgta
     7261 tttgaaggca ttatcgttat cgtcgtggga taaagagtct gggacaaaag tcctttagct
     7321 ccaaaaagca acggcataat gtactgaccc caaaaagtta gacaaataat ttaagtaaag
     7381 gatttagttc tgtattgtac aggactgagt ccttttagtt ttaccttaat gcgtttgttg
     7441 ttgtaataat taatatagtc tgcaattgct tgttccaaat gctcaattga cttaaacgtc
     7501 ttctcataac cataaaacat ctcagactta agaatgccaa agaaggattc catcatgccg
     7561 ttgtctggac tattgccttt acgtgacatg gatggttgga ttcctttctc ctctaaaaaa
     7621 tgatgataga aatcatgttg atattgccat ccctggtcac tatggagaat tgtatttttg
     7681 taatgtttct ctgtaaaggc ttgttctaac atagctttca cttgtatcaa gttcggtgac
     7741 ttagaaagat tgtaggcgat aatttcacta ttgaagccat ctaaaattgg cgacaaatag
     7801 agtttttggc tgcttgctgg aatggcaaat tctgttacat ctgtgtagca tttttccaat
     7861 ggtttggatg cttcgaactg gcgttggatg agattctctg ctttcatacc aacctctcct
     7921 tgatatgaag aatacttacg tttacggcga attctagcgg ttaaaccaag tactttcata
     7981 agacgttgaa ctctcttatg attaatcaca attcctcgat ttctcaattc aagagtcatt
     8041 cgacgatagc cgtaatttcc tttatgctca gtaaaaatgg cttgaatttc agctttaatg
     8101 tcataatcct tatcattttg atccagctgt tttaagtggt aataataggt tgaacgagca
     8161 agcttaataa tctttagaag catatctaaa gaaaactcag ttaccaatcc tcggacaatt
     8221 tccgtttttc ttcttgctct ttttcttccc tcaatcggag ttctctcaac tttttaagaa
     8281 ctgcattctc cgctctaagg tactcatttt ctgcttgaag acgttccatt tcttccagtt
     8341 ttttctttgg cttacgtccc attttagata accttcctct tgttttctca acaatagtat
     8401 acccgttttt cttatagtgt gcgagccagt taggaagcgt cccacgattt gggagagcat
     8461 attcaagaga aactctatct tgagaatagc ctttatatag gactttatca atcatttctt
     8521 gttttaattc aggagagtag taacgattct ttcctttttt agcgatttct attccgtatc
     8581 gatcaatcaa tttaatcatg tagctaagat tagaaatgtt tatcccaaat ttatttgaaa
     8641 gctgatctaa gctatatcct tggtttctaa gttcatagat ttgaacctta tcttcataag
     8701 tcaatttcat aataaaaaca ccccgaaagt tagatttttt ctgtctaact tttggggtgc
     8761 agttcataaa accgttgctt tttgcatgat tgtgatagac ttggtgaaat agaattgacc
     8821 aaaaatcttc tgaaatataa caagagagtg actcgaattt aaaaagctag agttccacaa
     8881 ttggaaatct ctagcttttt tgtgactgag aactttttgt cccagcctct actttctact
     8941 gactactatc ctgcatgccc taagtcgaga tagagaatat ctcgcttagt ggcatactct
     9001 agcgcatgtt caacagcctc aaataaatct gaagctagaa accttttcgt aaagacggtt
     9061 tcgtctttac gcttaaattt cgcaacataa ctatgtttag tcattttttc tccttctaat
     9121 attcatattg tcctttaaca ccactataga tccagtaaac tgctttatca taaacttgtt
     9181 taaaggagat acctaatcga ttggctacat caagaattga aatttgctta cattcctcta
     9241 tattcataaa atatcatcat tttgtcgtag tattcggcaa tgatggaaca gatgaggatt
     9301 cttctaaagt tttaggagtt gccttatcta gatcatctaa cccagatttc caaacctgta
     9361 cttggttgac caataactta ccaggtagtt tcgaatagtt caaattaacc gttctggttt
     9421 ctgtttagtt tgtctttgat tggttggcat tctttaaatc agatacataa gttacattat
     9481 aagagaccat ggcaatggct tgattcgtag tctgattgac aaagatatct gctttttcaa
     9541 aatgataatc caaaatatag tccttataca cttggttcat ggcatcattt tgacttgtca
     9601 attcttgaga ataggccgat tcagtcatat aaggttgaat acgtgtatta ttttccccta
     9661 gtttttcttt cgtatagtac tgtgtcaaaa attcttttac agtatctgat gataaaatac
     9721 ttgctttatc ttctgcttgt ttgtcctcta caagtttagc tgcagccaat tcgatttctt
     9781 ttcgactttg tttggcagta gaatgttgac caatagaatt agcagtaagt tgtggtgttg
     9841 atgaggtgga tatactaaaa aatgaggagg aaattgataa tgacttcacc tagctaaaag
     9901 ttcaacgaat tagggagaca ttaggtagcc tcatattacc ttgattagtt tttgctataa
     9961 cattgtcaaa tatgatgaca aaaaaatccg tccgcacttt tttacgagta ggacgaatta
    10021 aatatgttat acaaaccatc agctttttaa caattctaca taaggtagtt gttaatgcaa
    10081 ctaccttttt tctatgttga ttagaacaaa tttgacatgg ctacaactgc gattatctga
    10141 tatagagtat tatataaact gattcctcct accccttatc cacaatttta atacggctac
    10201 tgccatcgtg cgacttgatg ataactagtt gctgagcaat accttctttc atatcgtcca
    10261 cgtggctgat gacaccgacc atgcgatttt caccgatttg ttctaggaca gagatagcct
    10321 tagtgagggc ttccttatca agtgaaccga aaccttcgtc gatgaagagt gcttcaacaa
    10381 cggcaccctt gctggtattt tggacaactt ctgagaggga tagggcaatg gccagtgcag
    10441 cgataaaggt ttcaccacca gacaaggatt taacggagcg ttcactacct gtcagctggt
    10501 catagacgtt gatatccaaa ccgaagtgat cacgcgccct gcgtccttcc tcacttagaa
    10561 caaaggaata gcggttatcc gttaatagtc cgatgtagtt agcattggca tagtccaaga
    10621 tttgttggaa atactgacgg ataacgtaga cctcaagatt aagacgacca gttagagcag
    10681 tattttctcc cttaaccacc ttaaccaaat cactgagttc ttggtgggcc ttaaaggcct
    10741 cttggttgct gtcttgaagg gttttagccg cttggtaggt agccgtcgca tccttaagtc
    10801 ccttttccat gacagaaaac tgagcgagct gcctatcata gatttcctga caattctgta
    10861 ctgcttgcgc tagactatcg agatctggtt gttcttgatt ttggagaagc tcttgcccct
    10921 tacgaatctg cgcctgtaat tcttgtttga gcgttgcata ggtcgttaat ttggcctgaa
    10981 gcataggaat agcttgatta tttacctcaa taagccagag ttcgacctgc tctaagtcat
    11041 tggcgagggc tccttcagcc ttgagacttt gctctaattc agcagataat cgcttaacat
    11101 cttgatttac cttatcttta gacttagtta tactctcaat ctgccccttg attcctttaa
    11161 tgtcggcatg aagttggttg taggcttcgc tattttcctt gacttgctta ttgtagaggt
    11221 tcagctcctg atgagcaagg gaaatccgtt cttgatatac ctcaacagac tcaagttctg
    11281 gatgagcttc ctgcaagtcc tctaggcgtt cttgagcttg gtcaagcact gccttggcct
    11341 cttgataggt tttagccaaa tctgtcgctt ttttttgagc cttacctagc tcatcttgat
    11401 atcggatata atctgtctct tccttatcat aacgtttttg taactcttga taatactgct
    11461 caaccttcag gagtagggct tgcccacggt cagtttcata gtctatcgaa aaatcaaaat
    11521 caaaccgtcc cttaacgtgc tcttctaatt cttgatagtg cttttcaaga gttgccttga
    11581 ctttagtcac ttggtcaagc aaatcctgac gtttagatgc aacttcactc aaggtagcct
    11641 gacgatttga taaagtagcg acttgctttt ctttttgagc ttgaagcttc tccacctgat
    11701 ccatgagatt tttcaaggcc acttcatcag cctgtgctcc accaacatta gggtgttcca
    11761 gagcaccaca aaccatacaa ggatgcccct cctctaactc tgcctgcagt tggacaatca
    11821 tgagttgacg gcgtgaaacc aaagtccttc ttaactcctc ttccaattct ttgagaattt
    11881 cttgagcttg atcaatatca aaagataacg tttgatgacg tttttcggtc tttgtcaact
    11941 cctgattcaa gttctctatc tctttcaggt cctgagcaag ttgattctcc acactgtagc
    12001 ccacaatctg gaagagtttt tcggcctcat gtaaactctc taaactaaga cgattagcct
    12061 ccaagtcaga caaggacttg ttaagcatct caacctcttt tctagcctgc tgataggtct
    12121 cttccaactg cttgtagtta gtcgttgaac gtttgatttt ctcctgttct tgggcaagac
    12181 tctgggaata gataatatcc tctttccaag tttcaagctc ctcttctttt tgaagaaaat
    12241 cctcagattg aattgcgagt tcctcttttt tagccttaac atcctcaaac gcctgttgct
    12301 tttcacttaa ggcttcttga gcaatttcaa ggtcctgctc taattgcatc aactgtttcc
    12361 gatactgctt caaggtccga atggtttcct gcagaccttg agcaaactgt aattcctcca
    12421 gatgcacttt tgcctctgcc tgtccttgag ccccctcctc aatttccaga cggtaacgtt
    12481 ccttggcttg ctccaattct tgaaaaatct ttgccaaatc ttgggcagtt tggaagctct
    12541 tctgcagttg tgccaaatcc tcgtgggcag ccttcaagat acttttttgc tccgtaagac
    12601 tttcttgacg ctgagacaaa aactcttcaa gacgtgccaa tttttcagag gctggcgttg
    12661 acgccaagac agttaattct tcctccgacc aaacctgact ggcaaagtgg ctatctatct
    12721 gagcctgacg cttatccata tccttattgc tctgacgaag acgctcttcc aaactctttt
    12781 gaaaacggtc aaagatacct gtcccaaaga ttttctttaa aatttgagtc ttagtcttgg
    12841 aatcttcctt caaaaaacgg ctaaaatcat tttgcggtaa gaggataatc tgtttgaact
    12901 gctcagcatt gagccccaaa atctgctcaa tctggtcact cacttccttg atcttatccc
    12961 caagcttttc aatttcctga ccaccaatct tatccacaat gactagagaa gccgtcgcct
    13021 tttgcatggt agtgccccca ccctgcttgg ccctctcttg ctggagaact cggtcaatgc
    13081 gataaaggtg attgccttgt tggaaataga aagtcacctt ggtcaaatca tcctctggac
    13141 cagcgaaagt tgaccgcatc tcctcaacat tacgatcacc actggtcgta gcaaacaagg
    13201 ctaccgtcat ggcatcaaag agagtactct taccagcccc tgtatcccct ccaatcaaaa
    13261 agaggggagc atggtcaaac tgagtgaaat taataacttc cttacgatat ggtccaaaat
    13321 tggtcaattc taactggact ggtctcattg tcgactcctc tcaatctcct caaaaacact
    13381 ttccacaagg gcagtctgtc tctcagataa gacatcgccc ccagttactg tctggtaaaa
    13441 atcaaatacg atttcctggg gcgactgcat ttccaaatct tttaagtgct gatcaacggt
    13501 caagttttct tccctaacat cacccagacg actgaaagta atttctacaa tgtctgtccc
    13561 ataaatctct tccagtcggg cacgcacatt gataccctct aattccttac gactagacag
    13621 ttgaatatca aaggcgaacc aggctttttg acaaggttga ttcttataaa attcaggtga
    13681 catcaaggtt tcaaaagatt cctgtaaagc cacaatcggc cgtttaacct ctagagtatg
    13741 gaaggtctga gacatatcac cagacgcatc caattcaaga atatagacac ccttttcttc
    13801 cttacgcttg gcttctttga cattaaaggc gactggactg cctgaatatt gcacgcgctt
    13861 ggtaggacta gcaaaacgcg tatggatatg ccctaaggca acataatcga aagacttgaa
    13921 aaggtcactg gtcacattgg taagaccacc taccgtatta ctggtttcag acaacatcaa
    13981 ttctcgaaga ccctgaccat cgctatcatc cttcttagaa accgcaaaat gcgtcaccaa
    14041 gacatgagct ttgtcaggat caaaagcttt tttcatatcc tcaagaatgt aggtcaaggc
    14101 atcaccaatc ccctgaattt cctttccctc atcatcctta tagtaaatac gagcatcaat
    14161 aggatcgata aaaggcagca gaaaaatctg gcaattctcc aactcaatgg gctcaaaagc
    14221 ctcctccaaa cgtgtactta aatgaaggcc ctgatgttga aagaagtcac gcccaaaatg
    14281 taaacgttca gccccatcgt gattaccact aatcgcatag acaggaatct gctcctccag
    14341 taccaagcgg gccaaggtct tattaaaaag cttaatcgca tccacagggg gcaccgcacg
    14401 gtcatagagg tccccagaaa tgataacccc atccactttt tcgctaatag ccaaatccac
    14461 aatttgttga aaagcccact cctgctcctc caacaaagac cagccattga gggttcgtcc
    14521 tacatgccaa tctgacgtat gtaaaaactt catgacaacc tcctcattca ttttgtctta
    14581 cttctattgt accttatcaa gctaaatact gcttaaaagt ttcacaggct ttgatagttt
    14641 tcccgttttt tagctgtaaa gatcaaaaaa tctctcccaa gctatcctgt actgacccca
    14701 aaaagttaga caatttatgt aagcaaagga tttagctctg tattgcacag gattgagtcc
    14761 ttttagtttt accttaatgc atttgttgtt gtagtaatca atatagtcta gattaccctg
    14821 cctcaattgg ttaagtaatt taaatacctc taaccaagaa aatcaatatt atctattctt
    14881 ttaattgact tttatagatt ctaagcatta tcatataggt tggtactagt gcacatcttg
    14941 tattttaggc aataatattt actcactttt cgttattgtc agtaccgatc ctttttaaat
    15001 ttttcaccat gaaaacctaa aaataatccg aaccctaagg gctcctgact ttttacttta
    15061 ttctaggctt tttttatccg tagcttgtta gctgacttgg aactaggcat gtagtattta
    15121 ctatttccct acttgagatt ttttataagt cacatgcatt attccatctg aacgaatggt
    15181 atgattttta tttcttttag agaaacaccg gtaatagcta attcctatct taaatcactt
    15241 gaaatatatt tataatgtgt tggagtgcta atcagtaccg cttgtagatt tttggaagat
    15301 actaacacac taatgattta atctccttta aaacatgaaa agagaagcct ccaaagcttc
    15361 tcttttataa ttatcaaata atgtacaact agattcttaa taactaccta atttagtggt
    15421 tcaatcatga agcttaattg atagctatct gctgagctaa gcaagaattc gtcatgaact
    15481 ggagcacccc atgtgtcgtc accacctaca cccatttgag cagcaagaac tttaatccat
    15541 gtagcatcag attcttgcaa ctcatattgg tgacgagcat tttcaatttg ttcagtactg
    15601 ttacgcaaag cactgaattc gaatgcttta ttaagtgcgg tgaatttaag accattatgg
    15661 ttatcatcag atactgtgaa ttcacgagta ccatagtgat taccagattc ttgtggcatt
    15721 agatatggag caaatgtctt ttcaacagat gtttcatatc gaccaagata ggcaccagga
    15781 agtttatcac ggtagctttc ttctgcaccg tatccataat agctaaggtt tgtaaattgt
    15841 gaaccgatag caaattctag accaaattca gggaagtttg gcaaacctgc tttaccatca
    15901 tagtttgcag taacaaagat tcgacccttg taatcaactt gataagttac cttaacttcg
    15961 acatcagaca agcctggcaa ttcatgaaca taagtcactt taacagagtc gtcttcgatt
    16021 tgaatttgag tatctgtaac tttactatag tttccagcaa ccttccagcc tgccatttcg
    16081 aatggatatc cagcaccacg atcgttgtca gtgtaagcac gagtgaagct aagtttagga
    16141 cctttctcaa tgaattcaac accattatac ttagcagata ctaaagtatt ttgtgcacgt
    16201 gaaagcaaga ttgagaagtt ttgtccttga ataccgatgt tgaagtcgcc ttcaacaaca
    16261 ttcaaaggtg ctttaactgg tgtttcagtg ctaatctttt caacaacata ttgaccacga
    16321 acaatttcat gacctttagg agcccattca gttgcttccc tcagaacaca agcaacttcg
    16381 taaatttgtt cagaatttga agcctcgact acaaagttaa ctgggaatgt tgcttcttcg
    16441 cctggtttaa catcaaagtg atattcactt tcactaactt ttctaccatc ttcgtaaact
    16501 ctagctagga aagtataagc agaaagatct tcgaagagat tatcattctt gatagttact
    16561 gatttttcat caacagcaat cttaatatta gagtaaagat gtttaactgt ttgaagtttt
    16621 ggagttaggg tacgatctgc aaagacgata ccatttccac aaaattcgta gtcagaaggt
    16681 ctatcatgcc agtcaccacc atatgatagg aattcgctac catttggaag tgttttgtaa
    16741 atagcttggt caatgaagtc ccaaataaat ccaccttggt attctggata tttctctaag
    16801 tcagtgtaga gttgcaatcc accaccagag ttacccattg tgtgcatgta ttcacatgaa
    16861 atataaggtt tttgaggttt gttagttagg ttacctgaag caaagtgttt atcactaacg
    16921 cttgaaagat caactagttt accagttgtg aggtattctt cgatatcagc tggtttcgca
    16981 tacatacgac tttcgatgtc tgtaatgtaa tcaaactcac gacaccatgc aacaccttca
    17041 tagtgaactg gacgagtatt gtcaacacta cggaagtaat cagccatgtc agcaatatct
    17101 ttaccagcat atgattcatt accacaagac c
//
