LOCUS c00043_gnlPro.. 15566 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|EPOOICEK_60. ACCESSION c00043_gnlPro.. VERSION c00043_gnlPro.. KEYWORDS . SOURCE ORGANISM . COMMENT ##gutSMASH-Data-START## Version :: 1.0.0-1555cd7(changed) Run date :: 2025-04-29 13:17:48 Original ID :: gnl|Prokka|EPOOICEK_60 NOTE: This is a single cluster extracted from a larger record! Orig. start :: 47513 Orig. end :: 63079 ##gutSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..15566 /aStool="rule-based-clusters" /contig_edge="True" /core_location="[57513:62624]" /cutoff="10000" /detection_rule="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))" /neighbourhood="10000" /product="TPP_AA_metabolism" /protocluster_number="1" /tool="gutsmash" proto_core 10001..15111 /aStool="rule-based-clusters" /tool="gutsmash" /cutoff="10000" /detection_rule="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))" /neighbourhood="10000" /product="TPP_AA_metabolism" /protocluster_number="1" cand_cluster 1..15566 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))" /kind="single" /product="TPP_AA_metabolism" /protoclusters="1" /tool="gutsmash" region 1..15566 /candidate_cluster_numbers="1" /contig_edge="True" /product="TPP_AA_metabolism" /region_number="1" /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))" /tool="gutsmash" CDS complement(2151..5732) /locus_tag="ctg43_66" /transl_table=11 /translation="LAGHDVQYGKHRTRRSFSRIKEVLGLPNLIEIQTDSFKEFLDTGL KEVFEDVLPISNFTDTMELEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLINKETG EIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVI PNRGAWLELETDSKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIE KDIHKNPADSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKLN KKLNIKTRLLGQTIAENLVDPETGEILVEAGTEMTRDVIDSIAEHLDGDLNKFVYTPND YAVVTEPVVLQKFKVVAPNDPDRVVTIVGNANPDDKVRALTTADILAEMSYFLNLAEGI GKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEALTPQQIINIRPV TAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGR MCPIETPEGPNIGLINNLSTYGRLNKYGFIQTPYRKVDRATGKVTNEVVWLTADEEDEY IVAQANSKLNEDGTFAEEIVMGRHQGVNQEYPSHLVDFVDVSPKQVVAVATACIPFLEN DDSNRALMGANMQRQAVPLIDPKAPFVGTGMEYQAAHDSGAAVIAKHDGKVVYSDADKV EVRREDGSLDVYTIQKFRRSNSGTAYNQRTLVKVGDIVEKGDFIADGPSMEGGEMALGQ NPIVAYMTWEGYNFEDAVIMSERLVKDDVYTSVHLEEFESETRDTKLGPEEITRELPNV SEEALKNLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDT SLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGV VSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIYIATPVFD GASSEDLWDTVREAGMDSDAKTILYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARS VGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNILQEILTYKSDDVNGRLKAYE AITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDYEVELRDLDEGEDDDVMHVDD LEKARVQQAKEAAELEKAKEEALDKTE" CDS complement(6095..8350) /locus_tag="ctg43_67" /transl_table=11 /translation="MTLLDMGDVFLKTLKLLSDFFYVVIIVLTLFGAGIGLGYLGSQIQ SVPLIKDKTLLNQIGEVSLVSSMSYSDSKKIADIDTDLLRTPIESDAISNNVKNAIIAT EDENFNKHKGVVPKAVFRALVSSVLGVGSSSGGSTLTQQLIKQQVTGDTPTFKRKAAEI IYALQLERHASKNEILTDYLNVSPFGRNNKGKNIAGIEEAAQGIFGVSAADLTVPQAAY LAGLPQSPIVYSPYTADGQLKNEKDLSYGLARQKDVLYNLYRGGYLDKSQYESYKSYDV TKDFKAGENPDAVSHDYLYYSVMSEAQDIMYDYLVKRDKVSSQDLKNDKTKEAYREMAL RELQTGGYHVKTTIDNAVYHAMQDTANKYGDLLDQGGNNGVEVGNVLMDNATGAILGFV GGRNYENNQNNHAFDTARSPGSSIKPIIAYGIAIDQGLMGSSSILSNYPTNFTGGTPIL HDGDKGTAMMNLQEALNTSWNIPAFWTYQMLQHHDVDVEGYMTKMGYKIANYNIESLPL GGGIETTVAQQVNAYQMLSNGGVYEKGYMIDSITDSTGEVIYQHKSKGVQVFTRATASI MDNLLKEVVVKGATTQFYSELKNVNGAAASADWMGKTGTTDNFADAWLVVSTPGITLGG WAGYDDNAPTNSKMGYTYNAQYMARLTSAIYNANPGIFKTGDKFNIDSSAIKASVLKST GLKPATVSVNGRNVSVSGEMVDSYWAKNGPGDTIYKFAIGGTDSDYQKAWSSILGEH" CDS 8619..9875 /locus_tag="ctg43_68" /transl_table=11 /translation="MTIFEELKARGLIFQTTDEEALVKAFEEGPVSFYTGYDPTADSLH LGHLVAILTSRRLQLAGHKPYALVGGATGLIGDPSFNDAERSLQTKETVEGWVEKIQGQ LSRFLDFENGDNKAVMVNNYDWFGSVSFIDFLRDVGKYFTVNYMMSKESVKKRIETGIS YTEFAYQIMQGYDFYELNAKYGVTLQIGGSDQWGNMTAGTELLRRKADKSGHVITVPLI TDSTGKKFGKSEGNAVWLDATKTTPYEMYQFWLNVMDDDAVRFLKIFTFLSLEEIEEIG KEFDQARHQRLAQKVLAREVVTLVHGKEAYEQAVHITEQLFAGNLKALSARDLKVALNG VPTYEISADENLNIVELLVNAKISPSKRQAREDVQNGAIYINGERVQDLDYTLSDTDKI DNEITVIRRGKKKNFVLTY" CDS complement(10001..11023) /gene_functions="biosynthetic (rule-based-clusters) TPP_AA_metabolism: IlvC" /gene_functions="biosynthetic-additional (rule-based-clusters) IlvN" /gene_kind="biosynthetic" /locus_tag="ctg43_69" /sec_met_domain="IlvN (E-value: 7.4e-77, bitscore: 248.8, seeds: 43, tool: rule-based-clusters)" /sec_met_domain="IlvC (E-value: 3.1e-65, bitscore: 211.1, seeds: 295, tool: rule-based-clusters)" /transl_table=11 /translation="MAVQMEYEKDVKVPALDGKKIAVIGYGSQGHAHSQNLRDTGHDVI IGVRPGKSFDKAKEDGFDTYTVAEATKLADVIMILAPDEIQQELYEAEIAPNLEAGNAV GFAHGFNIHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKD IAMDWCKGIGAARVGLLETTYKEETEEDLFGEQAVLCGGLTALIETGFEVLTEAGYAPE LAYFEVLHEMKLIVDLIYEGGFKKMRQSISNTAEFGDYVSGPRVITEQVKENMKAVLAD IQNGKFANDFVNDYKAGRPKLTAYREEAANLEIEKVGAELRKAMPFVGQNDDDAFKIYN " CDS complement(11099..11575) /gene_functions="biosynthetic (rule-based-clusters) TPP_AA_metabolism: ALS_ss_C" /gene_kind="biosynthetic" /locus_tag="ctg43_70" /sec_met_domain="ALS_ss_C (E-value: 2.6e-28, bitscore: 90.4, seeds: 685, tool: rule-based-clusters)" /transl_table=11 /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGATENPDVSR ITIIIDVNSHNEVEQIIKQLNRQIDVIRIRDITDVPHLEREVILVKVSAPTSKRAEILA IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD" CDS complement(11568..13268) /gene_functions="biosynthetic (rule-based-clusters) TPP_AA_metabolism: TPP_enzyme_C" /gene_kind="biosynthetic" /locus_tag="ctg43_71" /sec_met_domain="TPP_enzyme_C (E-value: 9.9e-47, bitscore: 150.8, seeds: 323, tool: rule-based-clusters)" /transl_table=11 /translation="VEKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK NEEINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV FTGQVATSGIGKDAFQEADIVGITIPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV VIDLPKDVVAKETTFINDPEINLPSYQPTLRPNEMQINKILKQLGKAKKPVIVAGGGVA YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV VKNNTEKWIEKVKKDKERVRSYDKKERMVQPQAVIERIGELTDGDAVVVTDVGQHQMWT AQYYPYQNERQLVTSGGLGTMGFGVPAAIGAKIANPDKEVILFVGDGGFQMTNQELAIL NIYKVSIKVVMLNNHSLGMVRQWQESFYEGRTSESVFNALPDFQLMAQAYGIKSYKFDN PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA" CDS complement(13402..15111) /gene_functions="biosynthetic (rule-based-clusters) TPP_AA_metabolism: ILVD_EDD" /gene_kind="biosynthetic" /locus_tag="ctg43_72" /sec_met_domain="ILVD_EDD (E-value: 2.6e-221, bitscore: 727.9, seeds: 918, tool: rule-based-clusters)" /transl_table=11 /translation="MIKVGVDKAPARGLLYATGQVKSSKDMQKPFIAICNSYIDIVPGH VHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADAAETVIN AHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSLFEAV GTYQSGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILAVSDE RRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIAREAG IDYDLKDINDIAKKTPYLSKIAPSSIYTMHDVHEAGGVPAIINQLIKKGAIKGDRITVT GKTLKENVAGAKIKNEEIIHPIEQPILPVGGLSILYGNIAQDGAVIKVGGVDPSVKTFR GKAICCDSQAQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGLGKDV SLITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDVTLEA RRKHLNPFKSKISSGWLRRYTAFAKSANIGGTLMSNEEFEERKAERQAQEKN" CDS 15181..15333 /locus_tag="ctg43_73" /transl_table=11 /translation="MSMNFRNISVIPKNDFLVSKLFKQKGSIISVVGKTTVEIIELFEC TLKVP" CDS 15377..15565 /locus_tag="ctg43_74" /transl_table=11 /translation="MRPIKNTTELIGIKDQNIKISLVFETDTHIEIQAKLDYPAPSCPH CHGKMIKYDFQKPSKIPL" ORIGIN 1 tttcttcaac acggtggtga gcagcatcga taatttcttg tttgttatca ataactggga 61 tatcggcgat acccactgtc aatccagcaa gtgttgagta gtagtaacca aggtctttca 121 aacggtcaag gaaagctgat gtttcagttg tacgaagacg tttgaagatt tcagcaatga 181 tgttaccaag atgtttcttc ttgaatggcg cattaatttc caaactatcg ataactgttt 241 ggatatcttg gcccggttca aggaagtatt tatctggtgt actatctgtc aagttctcat 301 ttgttgtttc ttgaagatat ggaatttctg atggaatgat tgagttgaag agaatcttac 361 caacagttgt tactaagatt ttgtgaagtt ggttttcttt ccaaggttta tcaggcatgc 421 tatcgactgc aatacctaca cggctatgca agtgaacata accattatga taagccataa 481 ctgcctcatc aatatccttg aagatcatac cttcaccttc acggccttca tcttccattg 541 tcaagtaata gttaccaaga accatatcct gagatggtgt tacgactggt ttaccgtctt 601 tagggttaag gatgtgttct gccgcaagaa ggagcaaacg tgcttcagct tgagcttctt 661 cagacaatgg aacgtggatg gccatttggt caccgtcaaa gtcggcattg taggcctcac 721 ataccaatgg gtgaagacga agagccttac catcaatcaa gacgggttca aaggcctgga 781 tacccaaacg gtggagggta ggtgcgcggt taagaagcac tgggtgttcc ttgataacat 841 cttcaagaat atcccaaata cgttcatcac cacgctcaac catacgttta gcagctttca 901 cgttacctgc gtattcacgc gcaacgattt cacgcataac aaatggtttg aaaagttcga 961 tggccatcaa acggggcaca ccacattgat acattttaag tgttggacca acggcaataa 1021 cggaacggcc agagaagtcg acacgtttac caagcaagtt ttgacggaaa cgaccttgtt 1081 tacctttaag catgtggctc aaagatttaa gtggacgact acctggtcca gtaattggac 1141 gaccacgacg tccattatca ataagagcgt ctaccgcttc ttgcaacata cgtttttcgt 1201 tttgcacgat gatacctgga gcacccaact caagcaaacg agccaaacgg ttgttacggt 1261 tgataacacg acggtagagg tcgttcaagt cagatgctgc aaaacgtcca ccgtccaatt 1321 gaaccatcgg acgaagatct ggtggcaata ctggcaatat gttaagcacc atccattctg 1381 gtttattacc agacttgtaa aaggcgtcaa gaacgtccaa acgacgaact gctttaaaac 1441 gtttttgacc agttgctgtc ttcaactctt ctttgagttc agcaatttcg gcttccaaat 1501 ctacttgttt caagagatct tggatagctt ctgcacccat tttagcgaca aatgaaccat 1561 gaccatactc ttgcaatttt tcacgatatt cacgttcagt caagagagat tttggctcaa 1621 gcggtgtttc ctttggatcg ataaccacgt aagctgcgaa gtaaataact tcttcaagtg 1681 cacgaggact catatccaaa gtcaatccca tacgagaagg gattcccttg aagtaccaga 1741 tatgtgatac tggtgctttc aactcgatgt gacccatacg ttcgcgacga accttagcac 1801 gtgttacttc aacaccacag cggtcacaaa cgatcccttt ataacggata cgtttgtatt 1861 tcccacacgc acattcccag tctttagtag gaccaaagat cacttcgtcg aacagacctt 1921 cacgttctgg tttgagcgta cggtagttga ttgtttcagg tttcttaacc tcaccataag 1981 accatgaacg gaccttagtt ggtgaagcta gtgtaatttg catactttta aatcgattta 2041 cgtcaaccac tagtattacc tttcttttgt tctattgaca atagcagcgc tattttcacc 2101 tttatcagct accttagcag agaaatttaa ctccctctct aaagcttatt ttattctgtt 2161 ttatctaaag cttcttcttt agctttttct aattcagcag cttctttggc ttgttgtaca 2221 cgtgcttttt caagatcatc aacgtgcatg acgtcatcat cttcaccttc atcaagatca 2281 cgcaattcaa cttcatagtc atcctcatca agaacacgca tatcaagacc aagtgattgc 2341 aattctttaa cgagcactcg gaatgattct ggtacacctg gttttggaat tggttttcct 2401 ttagtgatag cttcataggc tttcaaacgt ccgttaacgt catctgactt gtaagtcaag 2461 atttcttgaa gaatgtttga agcaccgtaa gcttcaagag cccaaacctc catctcaccg 2521 aaacgttgtc caccaaattg tgctttacca ccaagaggtt gttgggtaac gagtgagtaa 2581 ggacctaccg aacgagcgtg aagtttatca tcaaccatgt ggtgaagttt gatcatgtac 2641 atgacaccaa ctgacacacg gttatcaaat ggctctcctg tacgtccatc gtaaaggatt 2701 gtcttagcat cactatccat accagcttca cgaacagtat cccagagatc ttctgagctt 2761 gccccatcaa agactggtgt tgcgatgtag atacccaagt tacgagcagc cataccaagg 2821 tgaagttcca taacctgacc aatattcata cgtgatggta ccccaagagg gttcaacatg 2881 atgtcaactg gtgtaccgtc tggaaggtaa ggcatgtctt caacaggaac aatacgagaa 2941 acaacccctt tgttaccgtg acgaccagcc atcttatctc cgaccttgat tttacgtttt 3001 tgagcgatgt aaacacgaac aagcatgtta acacctgatt gcaattcatc accgtttgca 3061 cgtgtaaaga ttttaacatc acgaacgaca ccatcaccac catgaggtac acggagtgat 3121 gtatcacgta cttcacgaga tttatcacca aagatagcat ggagaagacg ttcttcagca 3181 gaaaggtctt tttcaccctt aggtgttacc ttaccaacaa gaatatcacc ttctttaacc 3241 tcagcaccga tacggataat acccatttcg tcaaggtttt taagggcttc ttcactaacg 3301 tttggcaatt cacgtgtgat ttcttcaggt ccaagctttg tatcacgtgt ttctgattcg 3361 aattcttcca agtgaacaga tgtataaaca tcgtctttca ctaggcgttc actcatgata 3421 acagcatcct cgaagttgta accttcccat gtcatgtatg cgacaatagg gttttgaccg 3481 agggccattt ctccaccttc catagatgga ccatcagcga taaaatctcc tttttcgaca 3541 atatcaccaa ccttaaccaa agtacgttgg ttatacgcag tacctgagtt tgaacgacgg 3601 aatttttgaa tagtatagac gtcaagagaa ccatcttcac gacgaacttc aaccttatcg 3661 gcatcagaat agacaacttt accatcatgt ttagcgataa ctgcagcacc tgaatcgtgg 3721 gcagcttgat attccatacc agtaccaaca aatggtgctt ttggatcaat caatggcaca 3781 gcttgacgtt gcatgttggc acccatgagg gcacggttag agtcatcgtt ttccaagaaa 3841 ggaatacatg ctgtcgcaac ggcaactacc tgtttaggag aaacatccac gaaatctaca 3901 aggtgtgatg ggtactcttg gttaacacct tggtgacgac ccatgacaat ttcttctgca 3961 aatgttccat cttcgttcaa tttagagtta gcctgagcaa ctatgtactc atcttcttcg 4021 tcggcagtca accaaaccac ttcgtttgtt actttaccag ttgcacggtc aaccttacga 4081 tatggtgttt gaatgaaacc gtacttgtta aggcgtccgt atgtagacaa gttattgatc 4141 aaaccaatgt taggtccttc aggtgtttca attggacaca tacgaccgta gtgcgtgtaa 4201 tgcacgtcac gaacttcata tccggcacgg tcacgtgtca aaccaccagg tcccaaggct 4261 gacaaacgac gtttgtgtga caactctgac aatgggttgt gctggtccat gaactgtgac 4321 aactgtgaag aaccgaagaa ttctttaaca gctgcagtta caggacgaat attgatgatt 4381 tgttgtggtg tcaaggcttc attatcttga actgacatac gttcacgcac gtttcgttcc 4441 atacgagcca aaccaatacg gaattggtta gcaagcaatt caccaacggc acggatacga 4501 cggttaccaa ggtggtcgat atcatctact ttaccgatac cttcagcaag gttgaggaag 4561 tagctcattt cagccaagat atccgctgtt gtcaaagcac gaactttatc atctggattg 4621 gcattaccaa caattgtaac cacacgatct ggatcatttg gtgcaacgac cttgaatttt 4681 tgaagaacaa caggttctgt aaccactgca taatcgtttg gtgtgtatac aaatttgttc 4741 aaatcaccgt ccaagtgttc tgcgattgaa tcaatcacat cacgtgtcat ttcagtccca 4801 gcttcaacaa ggatttcacc tgtttcagga tctaccaagt tttcagcaat tgtttgtccc 4861 aaaagacgtg tcttgatgtt aagttttttg ttaagtttgt aacgaccaac agcagccaag 4921 tcgtaacgac gtggatcaaa gaaacgagct acaagcaagc tacgtgagct gtcagcagtt 4981 tttggttcac ctggacgaag tctttcataa atttctttaa gcgcttcatc agtacgtgaa 5041 tctgctggat ttttgtggat atctttttca atagtgttac gaaccaactc gctatcacca 5101 aagatatcaa caatttcgtc atcacctgag aatccaagtg cacgcacaag cgttgtaaat 5161 ggaatcttac gcgtacggtc gatacgagtg taggcgatgt cttttgaatc agtttcaagc 5221 tcaagccatg ccccacggtt aggaataact gttgatccgt aacccacttt accgttttta 5281 tcgaccttat cgttaaagta aacaccaggt gagcgcacca actgagaaac gataatacgt 5341 tcaccaccat tgatgataaa agtacccatc tcagtcataa ttgggaaatc tccgaagaag 5401 acttcctgag ttttaatttc accagtttct ttgttaataa gacggaaagt cacaaagatt 5461 ggtgctgagt atgatgcatc atggatacga gcttcttcaa gtgtatactt aggttccttc 5521 aattcgtaac caacaaattc caattccatg gtgtctgtga agtttgaaat aggaagtaca 5581 tcctcaaaaa cctctttaag accagtatct aagaattctt tgaatgaatc cgtttggatt 5641 tcaatcaagt ttggtaaacc aagaacttct ttgattcttg aaaaactacg acgggtacga 5701 tgcttcccgt attgaacgtc atgtcctgcc aagtcttcta ctccttttct acatttgaga 5761 cctgctttgc aagtcgtgca ctttaaatat ttgtctcctg ccttttttgg ttgcttgtcc 5821 cgataacaag tgattagata ttaacatcga cttatcggat taacgataag cgataacttt 5881 aatatgtgaa tttttagaac ttttaaatat tcattacaaa atccaaaaac cctaaaaata 5941 agcacaaaaa tagcagctaa atctgaccga aaaaacgttg atttaactgc tgtatctctt 6001 gattggacaa tatttcaatc aaataagacg acaaatagtt ttgtctatat tgtacctaaa 6061 ttttaactat tttgcaagta ttatttgaga cagcctaatg ttctccaaga atactagacc 6121 aagctttttg gtagtcacta tccgttccac caatggcaaa cttgtagatt gtatcgccag 6181 gtccattttt agcccaataa ctatcaacca tttcaccact tacggagaca ttacggccat 6241 tgaccgatac cgttgctggc ttaaggcctg tcgacttgag cacacttgcc ttaatggcgc 6301 ttgaatctat attaaactta tctcccgttt tgaaaatacc tggattagca ttatagatgg 6361 ctgaagtcaa acgagccata tattgggcat tgtaagtgta acccatttta gaattggtag 6421 gtgcattgtc atcataacca gcccaacccc caagggtaat gccaggcgtc gacacaacca 6481 accaagcatc agcaaagtta tcagttgtcc ctgttttacc catccagtca gctgaggccg 6541 ctgcaccatt gacatttttc aactccgaat aaaattgggt tgtcgctccc ttaaccacaa 6601 cttctttaag taagttatcc ataatgctag ccgtagccct tgtaaagacc tgaacccctt 6661 tagatttatg ttgataaata acctcaccag tgctatcagt aatactatca atcatataac 6721 ctttttcata aacaccgcca tttgaaagca tttgataggc gtttacctgc tgagcaacag 6781 tagtttcaat cccaccacca aggggcagac tctcaatatt gtagttagca atcttatatc 6841 ccatcttggt catatagccc tcaacgtcaa catcatgatg ttgaagcatt tgataggtcc 6901 aaaaggcagg aatattccac gacgtattaa gcgcctcttg caaattcatc atggccgttc 6961 ccttatcgcc atcatgaaga atcggtgtcc cacctgtaaa attagttgga taatttgaaa 7021 ggatacttga gctacccatt aaaccttggt caatggcaat tccataagca ataataggct 7081 taatagaaga tccaggagaa cgagcagtat caaaggcatg gttattctgg ttattctcat 7141 aattacgacc accaacaaat cctaaaatcg ctccagtcgc attgtccatg agtacatttc 7201 caacttcgac cccgttattt ccaccctgat caagtagatc tccatatttg ttcgcagtat 7261 cttgcatcgc atggtagaca gcattgtcaa ttgttgtctt aacatgataa ccacctgttt 7321 gtagctctcg gagagccatc tcacggtagg cttcctttgt cttatcattt ttcaaatctt 7381 gacttgatac cttgtcacgc ttcaccaaat aatcatacat gatatcttga gcttcagaca 7441 tgactgaata gtacaaatag tcatgactga cagcatctgg attctcacca gccttgaaat 7501 ctttagtaac gtcataactc ttataacttt cgtattgtga cttatctagg taaccgcctc 7561 gatagagatt gtagagcaca tctttctgac gtgccaagcc ataggaaaga tctttttcat 7621 tttttagttg accatccgca gtatagggtg aatagacaat cgggctctgt ggtaaacctg 7681 ccagataagc tgcctgagga actgtcaaat ctgcagcaga gaccccaaag atcccttgtg 7741 cagcctcttc gataccagca atatttttcc ccttgttgtt acgaccaaaa ggagaaacat 7801 tcagataatc agttaaaatt tcatttttcg aagcatgacg ttccagttgt agtgcataga 7861 taatctctgc cgctttacgt ttaaatgttg gagtatctcc tgtaacctgt tgttttatca 7921 actgctgtgt tagggttgaa ccaccactag aggaacctac ccccaagact gaggatacca 7981 aggctctaaa gacagctttt ggtacaaccc ccttatgctt attgaaattt tcatcctcag 8041 tagcaataat ggcattttta acattattag aaattgcatc actttcaata ggagttctaa 8101 gcaggtccgt atcaatatca gcaatctttt tagaatcaga ataactcatc gaagacacca 8161 aactaacctc gccaatctga ttcaacaagg ttttatcctt aatcaatgga acagactgta 8221 tctgactgcc cagataaccc aaaccaattc ctgcaccaaa tagggtaaga acgataataa 8281 ccacataaaa gaaatcagac aagagcttta aggtttttaa gaaaacatca cccatgtcta 8341 agagtgtcat cccatcctca ggcgacttcc gtgcttgctt acgattccac ttgaatccag 8401 tcgtagcttt cctttcttta aaagatttat ctcctctttt agacctagaa ccagcaaact 8461 ttgtacgaat agtctgccct agtcgcctaa aataatttat tattttttca aaattcatag 8521 aaatacctca aagcctatta taacaaactt tgacaaagct tgcatagggt tgcttctttt 8581 ggtataatgg tgcagaatat actttactgg agaatatcat gacaattttt gaagaactaa 8641 aagcacgtgg cttgattttt caaaccacag atgaagaagc ccttgtaaaa gcctttgaag 8701 aagggccagt ctcattctac actggttatg atccaacagc agacagtctc caccttggac 8761 acctcgtcgc tatccttact agtcgtcgcc ttcaattggc tggccacaaa ccttacgccc 8821 tcgttggggg tgcgacaggt ttgattggtg acccatcatt taatgatgct gagcgtagcc 8881 tccaaaccaa agaaaccgtt gaaggttggg tagaaaaaat ccaaggacaa ctctctcgtt 8941 tccttgattt tgaaaatggt gacaacaaag ccgttatggt caacaattat gactggtttg 9001 gttctgtcag cttcatcgat ttcttgcgtg atgtcggtaa atacttcaca gttaactaca 9061 tgatgagcaa ggaatctgtt aagaaacgta tcgaaacagg tatctcttac actgagttcg 9121 cttaccaaat tatgcaaggt tatgacttct atgaactcaa tgctaaatat ggcgtaaccc 9181 tacaaattgg tggttctgac caatggggta acatgacagc aggtactgag ctcttgcgtc 9241 gtaaagcgga taaatctgga cacgtaatca cagttccact tatcacagat tcaactggta 9301 aaaaattcgg caaatctgaa ggcaacgctg tctggcttga cgctactaag acaactcctt 9361 atgaaatgta ccaattctgg cttaacgtta tggacgatga tgccgttcgt ttcttgaaaa 9421 ttttcacttt cttgtcactt gaagaaatcg aagaaatcgg taaagaattt gaccaagctc 9481 gtcaccaacg tttagcacaa aaggttctgg ctcgcgaagt tgttactttg gttcacggta 9541 aagaagccta tgaacaagct gttcacatca ccgaacaact cttcgctggt aaccttaaag 9601 ccctctcagc acgtgacctt aaagttgccc tcaatggtgt cccaacctat gagatttcag 9661 cagatgaaaa tcttaacatt gttgaacttc tcgtcaatgc taaaatttca ccatctaaac 9721 gtcaagcacg tgaagacgtg caaaacggtg ctatctatat caacggtgaa cgcgtgcaag 9781 acttggatta cactctttca gataccgata agattgacaa tgaaatcact gttatccgtc 9841 gcggtaagaa gaaaaacttt gttttaactt actaatttat gaccattctc actccctagt 9901 ggagtgattt tttttacaca caaagccata agcttaacac ctaatcactt tcttaagaac 9961 acaaaaaacc agcactaggc tggtttttga gactatcaca ttagttatag attttgaatg 10021 catcatcgtc gttttgacca acgaatggca ttgctttacg caattcagca ccaacttttt 10081 cgatttcaag gttagcagct tcttcacggt aagcagtaag ttttggacgt ccagctttgt 10141 agtcgttaac gaagtcatta gcgaatttac cattttggat atcagcaaga actgctttca 10201 tgttttcttt aacttgttca gtgataacac gtggacctga tacatagtca ccgaattcag 10261 cagtgttaga aattgattga cgcattttct tgaatccacc ttcgtaaatc aagtcaacga 10321 ttaatttcat ttcgtgaagt acttcaaagt aagccaattc tggtgcatat ccagcttcag 10381 tcaagacttc aaaaccagtt tcgataaggg cagtcaaacc accacaaaga actgcttgtt 10441 caccaaacaa atcttcttca gtttcttctt tgtatgttgt ttcaagaaga cctacacgtg 10501 ctgcaccaat acctttacac cagtccatag cgatgtcttt agcgttacct gtggcatctt 10561 ggtatactgc gtaaagggca ggtacaccaa aaccttcttc aaatgtacga cgtaccaagt 10621 gacctggtcc tttaggtgca cacataaata catcaacatc tgctggtact ttaataaatt 10681 caaagtggat gttgaaaccg tgagcaaaac caacagcgtt accagcttca agatttggag 10741 cgatttctgc ttcgtaaagt tcttgttgga tttcgtctgg agccaaaatc atgataacat 10801 cagccaattt agttgcttct gctactgtgt aagtatcaaa accatcttct ttagctttat 10861 caaatgattt acctggacga acaccgatga taacatcgtg acctgtatca cgcaagtttt 10921 gtgagtgagc gtgaccttgt gaaccgtaac cgataacggc gattttttta ccatcaagtg 10981 ctggtacttt tacgtctttt tcatattcca tttgaactgc catagtagta tatctctttt 11041 ctaaaataat atttaattgc ctttttaagg ctaggttaac aaatttataa tggatttttt 11101 aatcacgggt aaatccagta gcacccgtac gagcaatatt cttgataccg taaggtcgaa 11161 taactcgtag aagcgcctca ctcttttcag catctccagt catctggata gtgatagagc 11221 ttggtgcaac atccaccacc gaagcacgga aaggttgaat gattgccaag atttcagcac 11281 gtttagaagt tggtgccgac accttaacca agataacctc acgttccaag tggggtacat 11341 cagtgatgtc acgaatgcga atcacatcaa tctgacgatt aagctgttta ataatctgct 11401 caacctcatt atgagaattc acatcaatga taattgtaat acgtgaaaca tcaggatttt 11461 ccgttgctcc aacggaaata ctctcaatat tgacctgacg gcgtgaaagc actccagtga 11521 aacggttaag aacacctgat cggttctgaa gtttagctgt taacattcta cgcattgaac 11581 ttcaccccca acatttcatg attactctta ccagctggaa caattggcaa aacatgctct 11641 ttacgagaaa tatcaacctc gatgaacatt ggcacatcct ctttgataac ttccaaatcc 11701 tgatcaatcg tttctggatt atcaaactta taagacttaa tcccataagc ttgagccatc 11761 agttgaaaat cagggagagc attaaagaca gactctgatg tacgcccttc gtagaaggac 11821 tcttgccatt gacgtaccat accaagtgag tggttattca acataacaac cttgattgac 11881 accttgtaaa tatttaaaat agccaattct tggttcgtca tttggaaacc accatcacca 11941 acaaagagga taacttcttt atcaggatta gcaattttag caccaattgc tgctggaaca 12001 ccaaatccca tagttccaag gccacctgat gtcaccaatt gacgctcatt ttgatatgga 12061 taatactgag ctgtccacat ttgatgttgc ccaacgtcag tgacaacaac tgcatcacca 12121 tcggtcaatt caccgatacg ctcgataacc gcctgaggct gtaccatacg ttctttctta 12181 tcgtaagaac gtacacgctc tttatctttt ttgacttttt caatccattt ttcagtgtta 12241 ttcttaacca ctggttctgc taagagcatt tcaagagctt gcttggcatc accaacaact 12301 ggcaaatcta ccgcaataat cttgccaatc tcagccggat ccacatcaat atgaacaacc 12361 tttgcattct tagcaaatgt ttttggatta cctgtcaagc ggtcatcaaa acgacaacct 12421 atggcaatca taaagtcagc atcagtcata gcaatattag ctgcatacga accgtgcata 12481 ccacccatac ccaaaaagag gggatgacta gtagcaattg ttccctgacc tagaagactt 12541 gtaacaacag gaatttggta gcgttctgca aaagcaacta gctccttagc agattcagaa 12601 taagccactc cacctccagc tacaataacc ggcttcttag ctttacccaa ctgtttcaag 12661 attttattaa tttgcatctc gtttggtctt agcgtcggtt ggtaacttgg aagattgatt 12721 tcaggatcgt tgatgaaggt agtttcctta gctacaacat cttttggaag gtctataaca 12781 accggaccag gacgtcctgt cgttgcgata tgaaccgctt ctcgaataat acgaggaata 12841 tcagccgtat cacgaatctg gtagttgtat ttggtaattg gaatggtaat tccgacaatg 12901 tcagcttctt ggaaggcatc cttaccaata cctgatgttg ctacctgacc cgtaaagacc 12961 agaagaggta cactatcact catagcatct gcaatcccag taatagcatt cgttgcaccg 13021 ggaccactcg ttacaagagc aacaccaagt ttcccagttg atttagcata accttcagct 13081 tcatgcaggc ttccttgctc atgacgagac aaaatatgat taatctcttc atttttgtaa 13141 atagcatcat acaaaggaag aaccgctccg ccaggatacc caaaaatggt tgaaatccca 13201 agttcgagaa gtgtatcaag aatcaaatca gcaccagagc gtgcttcttc aagttcaatt 13261 ttctccacat ggacctcctt tagcaattgt ttttttcaaa ttatctaaaa attcaaaacc 13321 ttgtatacta tactaacatt tttaactaaa tttgcaaggg tttcagagaa aaatatcaca 13381 aactcttcgg aaataatatt cttagttttt ttcttgtgcc tgacgttctg ctttacgttc 13441 ttcaaattct tcattactca taagagttcc tccgatatta gctgatttag caaaagcagt 13501 gtaacggcgt aaccagccac ttgagatctt agatttgaaa gggttcaagt gcttacggcg 13561 tgcttcaagt gtcacatcat caacgagcaa atcaagggta cgattcggaa gatcaatcac 13621 aatttcatcc ccatcttcaa tcagagctat attgccacct tccgcagctt ctggagatac 13681 gtgaccaata gcaataccac gagttgctcc tgagaaacga ccatcagtaa tcagagaaac 13741 atccttgcca agaccgcggc ctacaatctt agaggttggc gctaacatct ctggcatacc 13801 aggaccaccc tgaggaccct cgtaacgaat gacaacaaca tggcccttct taactgttcc 13861 attatcaatc aattcaagag cttgagcttg tgaatcgcaa caaatagcct taccacggaa 13921 agttttaacg gatggatcta caccaccaac cttgataaca gccccatcct gagcaatatt 13981 tccataaagg atagacaaac cgccaaccgg taaaataggt tgctcgattg gatggataat 14041 ttcttcattt ttgattttag caccagctac attttctttt aaggttttac cagtaaccgt 14101 aatacgatca cccttaatgg cacctttctt gatcaactga ttaataatgg ctggaacacc 14161 acctgcttca tgtacatcat gcatggtata gatgctggag ggagcaattt tagagagata 14221 aggtgtcttc ttagcaatat cattaatgtc cttaaggtca tagtcaatac cagcctcacg 14281 cgcaatagca agggtatgaa gaacggtatt ggttgaacca cccatagcca tatctagagc 14341 aaaagcatca tcgatggctt ctttggtcac aatatcacgt gggcgaacat tatttttgat 14401 gttatccatt aattttgtgg ctgcttgacg aaccaattca cgacgttcgt ctgaaacagc 14461 taggatagta ccgttacctg gaagggcaag acccaaaact tccattaaac agttcattga 14521 gttagcagta aacattcctg aacatgaacc acaagttgga caggcatttt tctctaaata 14581 atcaagctct tccttgctca tatctccaga ctggtaagta cctacagctt caaacaagct 14641 tgataaagta gcctgatgac cagtcatatc aacgccaccc ttcataggtc cacctgaaca 14701 gaataccgcc ggcacattag tacgcatggc tgccaaaatc attcctggtg taatcttatc 14761 acagtttggg atatagaaca caccgtcaaa ccagtgggca ttaataacgg tttctgcagc 14821 atcagcaatt aattctcgtg aagggaggct gtaacgcatc ccaatatgtc ccatggcaat 14881 cccgtcatcc acaccaatag tattaaactc aaaaggaata ccaccagctt cacggatagc 14941 ctccttggca atatccgcta attcacgtag gtggacatgt cctggaacaa tatcaatata 15001 agaattacaa atagcaataa agggcttttg catatcctta gaagatttaa cctgtccagt 15061 cgcatacaaa aggccacgtg ctggtgcttt atcaacacca actttgatca tatcacttct 15121 catgatctta ccttcaatct ataaaatttc ttacaacata tgttaccact ttggaaggta 15181 atgtcaatga attttcggaa tatttctgta attccaaaaa atgacttttt agtatcgaaa 15241 ctatttaaac aaaaaggctc tataatttct gtagtgggta aaactactgt agagattata 15301 gagctttttg agtgtacact aaaagtccca taagaactat aatgaaaagt gacaaaacta 15361 ccattaggaa gaacttatga gacctattaa gaataccaca gaattaatcg gaattaaaga 15421 ccaaaatatc aagatttcac ttgtttttga aactgatact catatcgaga ttcaagcaaa 15481 actcgattac cctgcaccat catgtcctca ctgccatgga aagatgatca agtacgactt 15541 tcaaaagcct tctaaaatcc ctcttc //