LOCUS       c00030_gnlPro..        14960 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIEPDPBA_30.
ACCESSION   c00030_gnlPro..
VERSION     c00030_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 08:10:46
            Original ID  :: gnl|Prokka|CIEPDPBA_30
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14960
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14960
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[100:4960]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      101..4960
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14960
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14960
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             2..70
                     /locus_tag="ctg30_1"
                     /transl_table=11
                     /translation="KQSLRVGLGFYCAGVEKLDFSI"
     CDS             101..1333
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_2"
                     /sec_met_domain="HBT (E-value: 5.5e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDMKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             1330..2445
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_3"
                     /sec_met_domain="Chorismate_bind (E-value: 1.5e-57,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             2465..4132
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-07, bitscore:
                     21.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRV
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSARGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             4136..4960
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg30_5"
                     /sec_met_domain="ECH_1 (E-value: 3.3e-82, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             5133..6158
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_6"
                     /sec_met_domain="MR_MLE_C (E-value: 6e-28, bitscore: 89.1,
                     seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILVKVCRKVEREQGRLDMDGLCDYPSILFGLETAIRHFF
                     AGNWALCDTAFSRGEVGIPINGLIWMGDFQNMLSQIEKKMEAGFRCIKLKIGAINFEEE
                     LTLLRHIRTHFSSKEIELRVDANGAFSPVDAMEKLKRLSEFDLHSIEQPICAGQWEEMA
                     RLAAESPLAIALDEELIGCNTLERKQELLSTIRPQYIVIKPSLHGGICGGDEWITEAEK
                     QQIGWWITSALESNIGLNAIAQWCATFSNPLPQGLGTGALFTDNVEVPLEIRKDCLWFC
                     K"
     CDS             6210..10244
                     /locus_tag="ctg30_7"
                     /transl_table=11
                     /translation="MAILAADKDKEIKTLFLKYMAWNMLPLLYNDALKKLCKMGFSLAK
                     ATKLLKSMQENGEIEIVSNLHYFGNKRCRLLPGIHLRYLWLMRNESFEEFEKEQSLPGY
                     IELQARTLCNAMLQWAATKELDNDIITHWPVDELTLPLFREMAYSTEWRDLYSKLSVGV
                     LYCIIDGYANRWNYWLEEIDELFVENLYLRNQSMPTSVKAYFREVYSFYEYVLSGRINE
                     IPENVTSRSVDGLCAHALYAQYHGNYSEALKIYRQALKDIESTYLFDTPFYSLTYVIAL
                     MREGSEASKKKMSGLVTKKRIREERQWLPAYLMLLIALGRDTKELVLWIERNYDLQSNM
                     VKALLYLLLEHYKLNEKIYIDNRPIEKLLENDRFKALQLEYSCDFQAFISKNAQLREEM
                     GVAPLLPSYAKQEPWEIALDRLAELVRNQETREVAKGTADNIARSRIVYHITNYGQIIP
                     RLQKSKDGITWTGGRNIALATFQQNAVEGMSELDKSLAACVKYFNAGYSIGDIYELGGP
                     KALSLLAGYPFVYMERNPDIPIVITKEELQLVVTQLKDGYQVSSNVKQLGSSNTILNKE
                     NDQLYRIVELTSEQRAILELFKQSSRFPLKAKDQLADVLGKLGRNVTIHSDLVRNKENL
                     KQIKGDSLITVQLLPVGDEIKVELFVKPFIEQPPYCKAGEGVGSVIGTMKGERVQAVRN
                     LKKEKENYVIVNQLLQRVSGDFTATDTAYFADYYQCLDLIEELRELSDVSRTEWPEGAK
                     LSIKGIADFPQLKLSMKGVGYWFEIDGELEIEDGVRMKISELLRKTRESGGRFIALNDS
                     DFIALSNQLRRKLQELDSILLNDKSLKVSSFNATLLADMEQQGILLKKDHKFKELQQKI
                     EQAENVRFIVPATLQAELRDYQMDGFRWLSRLAYWGAGACLADDMGLGKTIQAIALMLS
                     RGKKGASLVVAPASVLLNWQSEINRFAPSLTCRVLHDSCGDREQMIQETGDYDILLTTY
                     GLLNAEVVLLSKKQWNVILLDEAHTIKNKDTKMSKAAMQLNGEFRLLLTGTPIQNHLSE
                     IWNLFQFANPGLLGTFPHFNEKFILPIEKNGDKQRQKQLKRVLQPFLLRRTKNEVLDEL
                     PQKTEIVQKVELSSEEMALYENLRQQAVANIEESSLGAMQALAEITRLRQAACHPALIN
                     DKLKIDSSKTKVFMDLVDELIGNQHRALVFSQFTSHLALIRKELDLQGISYLYLDGTMS
                     VNEREKQVSRFQQGEGHLFLISLKAGGTGLNLTAADYVIHLDPWWNPAVEDQASDRVYR
                     IGQTRPVTIYRLIASNTIEEKIVTLHQSKKSLADSLLDGSNMAHKLTKEEMLELLRGGI
                     Q"
     CDS             10246..11337
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 55.5; E-value:
                     1.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg30_8"
                     /sec_met_domain="AMP-binding (E-value: 7.2e-18, bitscore:
                     55.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFEREKQSLLLEGVRYTANDLHLLKTKVVGASDSSTGQMLYDFL
                     QEWFTESPWMTVHTSGSTGKPKKIRISKDKMMQSARLTCEFLNLQIGDTALLCMNLRYI
                     GAMMVVVRSLVAGLNLIIRPASGHPLADMKQPLRFAAMVPLQVYNTLQVPEEKERLRQT
                     DVLIIGGGAIDETLEAEIRNLPGAIYSTYGMTETLSHIALRRLNGVLASERYYPFASVE
                     LSLSSENTLVIKAPLVCDDILQTNDIAHIYPDGSFTILGRKDNVINSGGIKIQAEEIEK
                     ILRPYIPVPFVITSVPDQRLGQAVTLLLEGQPDIKEIEDKLQSILEPYHRPKYVLYTDC
                     IPQTGNGKMNRAGCRDLAERLLS"
     CDS             complement(12106..12669)
                     /locus_tag="ctg30_9"
                     /transl_table=11
                     /translation="MKISFSKQTKERTFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKFETESFDLQSDTALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPIYET
                     EPDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYMPLLLLLLPYQ"
     CDS             12843..14834
                     /locus_tag="ctg30_10"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHPQEVSKSFIPMVEIPAGSFYMGSDGLGE
                     DFDEAPIHQVVISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYAPYSAEKQKDPAGPLAGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQESVKNTSIKWKKVS
                     AITPMFLPPIPFVVRPACDSNTPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMVVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGMEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDGG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLGNGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYIASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
ORIGIN
        1 gaagcagagt ttgagggttg gcctcggttt ttattgtgcc ggtgtagaaa aactcgattt
       61 ttctatataa ttttgtaatc taaatcaaaa tcgtgtaatc atgaagtata aattattggt
      121 tcttgatgta gacggaacac tcctcaatga tgcgaaagaa attagtaagc gtacattggc
      181 tgccctgttg aaggttcagc aaatgggagt acgtattgtg ctggcatccg gcagaccgac
      241 ttatggcctg atgccgttgg ccaagatgct tgaacttgga aactatggag gttttatcct
      301 ttcctataat ggctgtcaga ttatcaatgc acaaaacggg gaaattctgt ttgaacgtcg
      361 gattaatccc gaaatgttgc cgtatctgga aaagaaagcc cgtaaaaacg gttttgcctt
      421 attcacttat catgatgata cgattataac ggattctcct gaaaatgaac atatccaaaa
      481 tgaagcccgg ttgaataacc tgcaaataat taaagaagaa gaattttctg ctgccgttga
      541 ttttgctcct tgtaagtgta tgctggtgag cgatgacgaa gaagcactgg ttggtttgga
      601 agatcactgg aagagacgac tgaacggagc gttggacgta ttccgttcgg agccatattt
      661 tctggaagta gttccctgcg ccatcgacaa agccaactct ttgggcgctt tgctggaggt
      721 gctggatatg aagcgtgagg aagtgattgc tgtaggcgat ggtgtgtgtg acgtaacaat
      781 gattcaattg gccgggctgg gcgtagctat gggacattca caagactcgg tgaaagcctg
      841 tgccgactat gtgaccgctt cgaatgagga agacggagtg gccgttgcag tggagaaggc
      901 tattatagct gaagtgcgtg ctgctgaaat tccccttgac caactgaatg cgcaggcacg
      961 ccacgcatta atgggaaact tgggaattca atatacatac gccgacgaag accgtgtgga
     1021 agcaacgatg ccggtagacc atcgtacccg tcagcctttt ggcattttgc atggtggagc
     1081 tactcttgcg ttggcggaaa cagttgccgg actcggttcg atgattcttt gccagccgga
     1141 cgagattgta gtaggaatgc aggtcagcgg aaaccatata tcttctgcac atgaaggaga
     1201 tacagtgcgt gcggtaggaa cagttgtaca taagggacgt tcctcccacg tatggaatgt
     1261 agacgtgttt acttcaacaa acaaactggt gtcttccata cgggtagtca acagtgtgat
     1321 gaaaaagaga tgaccgacga agaaataagt aacttgacaa ctattgatgc atttattcag
     1381 cggaagcagc cgtttgctgt ttaccgtatt cccggagaga aagttccccg tctgttgacg
     1441 caggcggaag gagcggtccg tttgatatac gatttgaaag aactgaatgg acagagagga
     1501 tttgtaattg ctccgtttca ggtgagtgag tcatgtccgg ttgtgttgat tcaacccgat
     1561 cagtgggggc agcctttacc cgtggatgat gatacggaag aagatcggga gatagccttg
     1621 cgcctgcaag gacaagaatc atttctgact tcttctacgg aagaatatgc ggcatgcttt
     1681 cataccttta taaatgcgtt acgtgacagg acgtttgata aactagtgct ttcccgtcat
     1741 cttacagttg ataaagttgc ggatttttct cctttgtcca tctttcgggc ggcttgtaaa
     1801 cgttatattc attcgtatat ttacttatgt tatactccgc agacgggcat ctggctggga
     1861 agtactcccg aaatcatttt atcaggtgag aaagacgaat ggcatacggt tgcactagcc
     1921 ggaacacagc ctttgcaaga tggcagattg ccgcaagtat gggatgaaaa gaaccggaaa
     1981 gaacaagatt atgttgcttc ttatatccgt cggcagcttc tttcactgga tattcattct
     2041 acggaaaacg ggccatatcc tgcttatgcc ggtgctttgt cacatttaaa aactgatttc
     2101 cgtttttctt tgaaagataa taaaggtttg ggagaccttc tgaaagtttt gcatccgaca
     2161 cctgccgtat gcggcttgcc gaaagaagaa gcctatcagt ttattttgca gaatgaaggt
     2221 tacgaccgcc gctattactc cggctttatc ggatggctcg atccggaagg acgaacagac
     2281 atctatgtaa acttacgctg tatgcatatc gaagataaac aacttactct ttatgccggc
     2341 ggtggattat tggcctcttc ggaattgaat gacgaatggc tggaaacgga gaagaagttg
     2401 caaactatca aacggctgat tgcagtgcct cctttaaaat cataaactac taataattat
     2461 catcatgtat acagacaaga agaacatact ccagttggtt gcgttgctcg aggcgcatgg
     2521 gattactaag gttgtgttgt gtccgggtag tcggaatacg cccatagtac atactttgtc
     2581 taaccatccg aattttacct gctatccggt gacggatgaa cggagtgccg gctattttgc
     2641 catcggtctt gcgttgaatg gtggtaagcc cgcagctgtc tgttgcactt ccggtactgc
     2701 attattaaac cttcatccgg ctgtggcaga agcattttat caaaatgttc ctctggtcat
     2761 tatttctgcg gatcgtcccg ctgcctggat cgggcagatg gatggacaga cagtaccaca
     2821 accaggcgta tttcagacat tagttaagaa gtcggtaaac cttccggaga ttcatacgga
     2881 agaagatgaa tggtattgca atcgtctggt gaatgaagct ttgctggaaa cgaaccatca
     2941 tggaaaagga ccggtacata tcaatgtccc tatttctgaa ccgttgttcc agtttacggt
     3001 tgattcgctt cctgaagtgc gtgtcattac ccgttatcag gggttgaacg tctacgatcg
     3061 tgattataac gatttggtcg atcggatgaa taaataccag aagcgtatga ttatcatcgg
     3121 tcagatgaat cttatctatc tgtttgaaaa aagatatatc aagttattat ataaacattt
     3181 tgcctggttg acggaacata tcggcaacca gacagttccc ggtattccgg taaagaactt
     3241 tgatgcggcg ctttatgcca tgcccgaaga gaaggtcggc cagatggttc cggagttgct
     3301 gattacttat ggaggacatg tcgtttccaa acggctgaag aagtttctcc gtcagcatcc
     3361 gcctaaagaa cattggcacg tatcgccgga cggtgaggtg gtcgatttgt acggctcatt
     3421 aactacggtg atcgaaatgg acccgttcga gtttctggag aagatagcca gtttgttgga
     3481 caatcggact cctgaatatc cccgtgtgtg ggaaaactat tgcaagatca ttcccgaacc
     3541 ggagtttgct tattcggaaa tgtctgccgt cggtacgtta ttgaaagcct tgccggagtc
     3601 atgtgcgttg catttggcaa acagttcggt ggtgcgttat gcgcaattat actccattcc
     3661 ttctacgatt gaagtttgtt gcaaccgggg aacaaacggt attgaaggct cgctgtctac
     3721 ggctgtcggt tatgcggcag cttccgacaa actgaacttt atagctattg gagatttgag
     3781 cttcttctat gatatgaatg cgttgtggaa cgtcaatgtt cgctccaatc tgcgtgttct
     3841 tctgttaaat aatggaggag gagagatttt ccataccttg ccgggattgg atatgtcggg
     3901 tacctcacat aaatttattg cggcagtcca taaaacgtcg gccagaggtt gggcagagga
     3961 acgtggattc ctctatctgc aagcacaaaa tgacgaagaa ctggctgaag cgatgaaaac
     4021 tttcactcaa ccggaagcta tggagcagcc tgtgctcttg gaggtgttta ccaacaaaaa
     4081 caaggacgcg cgcatgttga agaattatta tcatcaatta aaacaaaaat agattatgtc
     4141 aacacaaaga gagtggacaa ccattagaga atacgacgat attctttttg attattataa
     4201 tggaattgcc cgtatcacga tcaaccgtga gcgttatcgg aatgcgttta ctccgacaac
     4261 tactgctgaa atgagtgacg cattgcgcat ctgccgtgaa gaagcggata ttgatgtgat
     4321 tgtgattacc ggagccggtg ataaggcatt ttgttcgggt ggcgaccaga atgtgaaagg
     4381 acgtggcgga tatatcggaa aagatggtgt gcctcgtctt agcgtattgg atgtgcaaaa
     4441 gcagattcgc agcatcccga aaccggtgat tgctgccgtg aatggttttg ctattggtgg
     4501 cggacatgtg cttcatgtgg tatgtgattt gtccattgcg tcggaaaatg ctattttcgg
     4561 tcagacgggt cctcgtgtcg gtagctttga tgccggattc ggtgcgtctt atctggcacg
     4621 tgtagtgggg cagaagaaag cgcgcgaaat ctggttcctc tgccggaagt ataatgcaca
     4681 agaagcattg gacatgggat tagtgaataa agtagttcct ttggagcagt tggaggacga
     4741 atatgtacag tgggcggaag aaatgatgtt gcttagtccg ttggctttgc gcatgattaa
     4801 agcaggattg aatgccgaac tggatggtca ggcaggtatt caggaattgg caggtgacgc
     4861 aacgttgctc tattacctga ctgatgaagc acaggaaggc aagaatgcgt ttctggagaa
     4921 acgtaaaccg aacttcaaac aatatccgaa attcccttaa aatcggcttt gccacagagt
     4981 accacagagt ttgcttttcc tgcgtttaag cccgattttc tgcaaagcaa gactgtggag
     5041 gagagaatgg taggagaact gcaagagata taacttatta aaacttcgtg aggctctgtg
     5101 ttattctgtg gtgaattgaa aaattattca cgatgaattg taaaatagaa attattcccc
     5161 gattgctcca tttcaagcaa cctgccggga cttccagagg aacatatact acgcgtaaag
     5221 tttggtatct tcattttacc tctcctgact tccctggcag agtgggaata ggggagtgtg
     5281 cacctttgcc cgctttaagt tgtgacgatc ttcctgatta cgaagatata ttagtgaaag
     5341 tctgccggaa agtagagagg gaacaaggca gattggatat ggatggcttg tgtgactatc
     5401 cttcaatttt atttggtctg gaaacggcca tccggcattt ctttgcagga aactgggctt
     5461 tatgtgatac ggctttctca cgtggagaag ttggtattcc gattaacggc cttatttgga
     5521 tgggagattt tcagaacatg ttatcccaga ttgagaaaaa gatggaagcc ggatttcgtt
     5581 gtatcaagtt aaagataggt gccatcaatt tcgaagaaga actgacattg ttgcgccata
     5641 ttcgtacgca tttctcttct aaagaaatag agttgcgtgt agatgcaaat ggtgctttct
     5701 cacccgtgga cgcaatggaa aaactgaaac gtctgtccga gtttgattta cattctatcg
     5761 aacagccaat ctgtgccgga caatgggagg aaatggctcg gcttgctgcc gaatctccat
     5821 tagcgattgc tttggatgaa gaactgatag gatgcaatac gctggaaagg aaacaggagc
     5881 tgctttcaac aattcgtccg caatatatcg ttattaaacc ttctcttcat ggaggaatat
     5941 gcggaggaga cgaatggatt accgaagctg aaaaacaaca gatcggctgg tggataactt
     6001 ccgctctgga atcaaacatt ggtctgaacg ccattgccca gtggtgtgca acattcagca
     6061 atccgttgcc acagggactg ggaacagggg cgctctttac agacaacgtg gaagtgcctc
     6121 ttgaaataag aaaagattgc ctgtggtttt gtaaatgatg gtgttaaagg atattcgact
     6181 ggtaacgaca aaacatagaa ctaaaaaaga tggcaatatt agctgctgat aaagacaaag
     6241 agattaaaac ccttttctta aaatatatgg cttggaacat gcttccattg ctatataacg
     6301 atgcattgaa gaaactctgt aagatgggat ttagccttgc caaggctact aagttgctga
     6361 agtcaatgca agagaatggc gagatagaaa tcgtttcaaa cctgcattat ttcgggaata
     6421 aaagatgtcg gttgctgccc ggcatccatc tccggtattt atggctgatg cgaaatgaat
     6481 cgtttgaaga atttgaaaaa gaacaatctc tccccggata tattgagctg caagcgagaa
     6541 cattgtgtaa tgcgatgtta caatgggctg cgacgaagga attggataat gatataataa
     6601 cgcattggcc ggtagacgaa ttgacactgc ctctatttcg tgaaatggca tattctaccg
     6661 aatggcgaga tttatacagt aaactttctg tcggtgtttt atattgtatt atcgatggat
     6721 atgccaatcg ttggaattac tggctggaag aaatagacga gctttttgtt gaaaatctat
     6781 atctaaggaa tcaatcaatg cctacttccg ttaaagcgta ttttcgggaa gtttattcat
     6841 tttatgaata tgtattgtct ggtcgtatca atgaaatccc ggagaatgta acgtcccgct
     6901 ctgtggatgg tttatgcgcc catgcgcttt atgcccaata tcatggaaat tattcagagg
     6961 cacttaaaat atatcggcaa gctctcaaag atatagaaag tacctatctt tttgatacgc
     7021 ctttctattc gttaacgtat gtcatagcac taatgcgcga gggtagtgag gcttcaaaga
     7081 aaaagatgag cggattagtg acaaagaaac ggattcgtga agaaaggcaa tggctgccgg
     7141 cttatctgat gcttttgatt gctttaggaa gagatactaa agaattagtc ttatggatag
     7201 agcggaacta tgacctgcaa tcgaatatgg taaaagcatt attgtattta cttctcgaac
     7261 attataagct gaatgagaaa atctatatag acaatcgccc tattgagaaa ctgcttgaaa
     7321 acgatcgttt taaagcattg cagttagaat attcatgcga ctttcaggct tttatttcta
     7381 aaaatgcgca attgagggaa gagatgggag tggctcccct gcttccttct tatgctaaac
     7441 aggaaccttg ggaaattgcg ttggacagat tagcggagct ggttcggaat caggaaacca
     7501 gagaagtagc gaaaggaacc gctgataaca tagctcggtc acgcattgta tatcatataa
     7561 cgaattatgg tcagatcatt ccccgacttc aaaagtcgaa agacggaata acctggacgg
     7621 gagggaggaa tatagctttg gctactttcc agcagaacgc agtagaaggg atgagcgaac
     7681 tagacaagag ccttgcggca tgtgtcaagt actttaatgc cggatattct ataggagaca
     7741 tttatgagtt gggcggaccc aaggcgttat ctcttttggc gggttatcca tttgtgtata
     7801 tggagagaaa tccggatatt cctattgtaa tcacgaaaga agaactacag ttggtggtta
     7861 ctcaactgaa agacggttat caggtgagca gtaatgtgaa acagttggga agttcgaata
     7921 ctattttaaa taaggagaat gatcagctct atcggattgt agaactgacc tcggaacagc
     7981 gtgccatatt ggaactcttc aaacaatcct cccgctttcc gttaaaagct aaagaccagt
     8041 tggcggacgt gttggggaaa ttgggaagaa acgtgacgat acattcggac ttggtacgca
     8101 ataaagaaaa tctcaagcaa ataaaaggag attcattgat aaccgttcag ctgttgcccg
     8161 taggagacga aatcaaggtg gaactttttg taaaaccttt catcgaacag ccgccttatt
     8221 gcaaagccgg tgagggagtg ggaagcgtga ttggaacaat gaagggcgaa cgtgtgcagg
     8281 cggtacgcaa tttgaagaaa gaaaaagaaa attatgtgat agtcaaccag ctacttcaac
     8341 gggtcagcgg agactttacg gctacggata cggcttactt tgcagattac tatcaatgtc
     8401 tggatctgat agaagagctt cgcgagctgt cagatgtgtc gcgtaccgag tggccggagg
     8461 gtgctaaatt gtctataaag ggcattgcgg attttccaca actgaagctt tctatgaaag
     8521 gggtaggata ctggttcgag atagatggag agttggagat agaagacgga gtccggatga
     8581 agatttccga acttctgcgg aaaacccgtg aaagcggggg gcgttttata gcgttgaatg
     8641 actctgattt catcgcatta agcaatcagt tacgtcggaa gttgcaagaa cttgattcta
     8701 tcctgctgaa tgataaaagt ctgaaagttt ccagctttaa cgccactttg cttgctgata
     8761 tggaacaaca gggaatcctg ctgaaaaaag accataagtt taaggaacta cagcaaaaaa
     8821 tagaacaggc agaaaatgtc cggttcatcg tacctgccac attgcaggct gaattgcgtg
     8881 attatcagat ggatggattc cggtggttat cacgattggc gtactgggga gccggtgctt
     8941 gtctggcgga tgatatggga ttgggaaaaa cgatacaagc cattgctctg atgctcagca
     9001 gagggaagaa aggtgcttct ttggttgtcg ctcctgcatc cgtattgctt aactggcaga
     9061 gtgaaatcaa ccgttttgct ccttcgctta cttgccgggt gctacatgac agctgcggtg
     9121 atcgggagca aatgatacag gagacaggtg attatgatat attgcttact acttatggat
     9181 tgttgaatgc ggaggttgta ttgttgagca agaagcagtg gaatgtcatc ctgctggacg
     9241 aagcccatac aattaagaat aaagacacca aaatgtccaa ggcggcgatg caactcaacg
     9301 gtgaattccg tttgttgttg accggaactc ccatacagaa ccatctaagt gaaatctgga
     9361 acttatttca gtttgccaat cccggtttac tggggacatt tccgcatttt aatgaaaagt
     9421 ttattctgcc cattgagaaa aacggagata agcaacggca aaaacaatta aagagagtgc
     9481 tgcaaccttt tctgcttcga cgtaccaaaa atgaggtttt ggacgaattg ccgcagaaaa
     9541 cagaaatagt gcagaaggta gaactgtctt ccgaggaaat ggctttgtat gagaatctcc
     9601 gtcagcaggc tgttgctaat atcgaggaaa gttcgttggg ggctatgcag gcattggcgg
     9661 aaatcactcg tttacgtcag gcggcctgtc atccggcttt gatcaatgat aagctgaaaa
     9721 ttgactcatc caagacaaaa gtatttatgg atttggtaga tgaacttatc ggcaatcagc
     9781 accgtgcgtt agtattcagc cagttcacgt ctcatctggc tttgattcgc aaagaacttg
     9841 atttgcaggg catttcctat ctttatttgg atggaacgat gtctgtaaat gagcgtgaaa
     9901 aacaggtcag ccggtttcaa caaggagagg gacacctgtt tttgattagt ctcaaagcgg
     9961 gaggtacagg gctgaacctg acagccgccg attatgtgat tcatttggat ccatggtgga
    10021 atcctgctgt cgaagaccaa gcttcagacc gtgtttaccg tataggtcaa actcgccctg
    10081 tcaccatcta tcggctgata gcttccaata cgattgaaga gaagattgtc acgctgcatc
    10141 aaagtaagaa atcattggcg gattctctac tggatggaag caatatggcg cataaattga
    10201 ctaaagaaga aatgttggaa ctgttgcgag gaggcattca ataaaatgga atttgagaga
    10261 gaaaagcaat cgcttctgct tgaaggggta cgatatacag ccaatgattt gcatttgttg
    10321 aaaacaaagg tggtaggagc atccgattct tctacagggc agatgttgta tgatttcctg
    10381 caagagtggt ttaccgaatc tccttggatg acagttcata cttcgggatc taccggaaaa
    10441 ccgaaaaaga taaggattag caaggataaa atgatgcaaa gcgcacgtct gacctgcgaa
    10501 tttctgaatt tgcaaatagg agacactgct ttgttatgca tgaatctccg ttatatcgga
    10561 gctatgatgg tagtcgtacg ctctttggtt gcaggtttga atctgattat acgtcccgct
    10621 tccggtcatc cgttagcgga tatgaaacag cctttgagat ttgcggcaat ggttcctctg
    10681 caagtttata ataccctgca ggtgcctgaa gaaaaagaac ggttgcgaca aacggatgtt
    10741 ctgataatcg gtggtggagc aatcgatgag actttggaag cagaaatcag aaatcttccg
    10801 ggtgctatct attctactta tggcatgacc gaaacgttgt ctcatattgc tctccgtcgt
    10861 ctgaatgggg tattagcttc cgaacgctat tacccttttg cttctgtgga actgtcttta
    10921 tcttccgaaa acacattggt cattaaagcc cctttggtat gcgatgatat tttgcaaacc
    10981 aatgacatag cgcatattta tcccgatgga agttttacta ttctcggtcg gaaagacaat
    11041 gtcatcaata gcggcggaat aaaaatccag gcagaggaaa tagaaaaaat ccttcgcccg
    11101 tatattcccg tgccgtttgt catcacttcc gtaccggatc agcgtttggg gcaggcggtg
    11161 actttgttgc tggaagggca gccggacata aaagaaatag aagacaaact acagagtata
    11221 ttagaacctt atcatcgtcc taaatacgtt ttatatacag actgtatacc gcagacgggt
    11281 aatgggaaga tgaatcgtgc gggttgccgt gatttggcgg aacggttatt atcgtagttt
    11341 gaaagtgaat gttataccgt cgaccaccgc aaattggtaa agataggtgt ggacttcgac
    11401 aaagaaaccc gtaatatcgg tcgctggttg gttcaataag agagccgggg ctcatctcat
    11461 acttcttcta aacgcatcaa acaccatttt ccagtttgtt gagaacaaca taactatgat
    11521 gctcatatcg aaggttcata ggtttcacac ttgtttgaat tgttataaat cagacgatta
    11581 cggtgataga aatctgtgaa tctaggataa ataatccttc acctcttcac ctcattataa
    11641 gctatcaaga tattgggtaa gtttattcag attcatacac attcagatgt cagatacctt
    11701 catcttaaga aatccggagg tgacctactt ttatctgtta atttgaagtt taacgaacta
    11761 ttgtagatgc tccctcataa tatactaata gataaactct aggctattaa tagaaaactt
    11821 ccactctgtt acgcctaaac ttcttttgta tggcttgcaa acttatattc tgcttattat
    11881 aaactataaa cgaagttttc atttttataa atgtaacctt tgtttttata attgcaactt
    11941 gcgtttataa aaacaaagct tgcatttata gtttgttgtt aggcaaatgt aactttgtaa
    12001 ctaatgcaaa gaaagtttgg tcttaatagg aaggaagtta tctattaata gtttggagtt
    12061 tacttactaa tagacaatat gacaattgac aataaaaaaa taaacttatt gataaggtaa
    12121 taatagaagg agtaatggca tatagtcttt caattcattc ctcaaaagtt ccatcgtctt
    12181 ttgtttgtat cggttgatag atttcacgct aagattcatt tcttctgcga tctctgcatg
    12241 tgttttacct tcaaagaaac ttttcataaa aacagtgcga tagttttcgg gtaacttatt
    12301 cagtgtctcg tacaacattc tgtatagttc atcgagagta tacacactat ctggctctgt
    12361 ctcatagata ggcgctttct tttgaatgtt ttcggcataa ctccattcat attcttgatg
    12421 tttcaggaaa ttcagacaac tgttttttac acacatcttg atgtatccca atgccgtgtc
    12481 cgattgcaag tcaaaggatt cagtttcaaa cttatcccat aatgaagtaa atacatctga
    12541 aacgatatct tcacgtgttt ctttatcatc aacaaacctt tttgcataca gacaaaatgg
    12601 ggcgtaatat tcctcataaa gttgtttgaa agtccgttct ttagtttgtt tggaaaaaga
    12661 tattttcatt atttagagat tctgtagttt ttcattttgc tgcaaatata taataagata
    12721 attatcagag cctaattttc gattcttttt tttgctttca cccctaatga atggaaaata
    12781 atcagataag actgtccttt tgtatatagg ttgattgtat tatatataaa caggattaaa
    12841 atatgaaaaa caagtttttt ttattggcta taaccttttg tttgccaata catcctcaag
    12901 aagtttccaa gtcttttatt ccgatggttg aaatacctgc cggaagtttt tatatgggaa
    12961 gtgacggatt aggcgaagat tttgatgagg ctcctatcca tcaggtagta atctctcgcc
    13021 cgtttcgtat gggaatcact gaaataacga atgcgcaata tgagtcattc cgtccggaac
    13081 atcgggcatt acgaggaaaa aacggtgttt cgctggaaga tgatgaagca gtcgtcaatg
    13141 tgagttattc cgatgctgtt gccttttgtg aatggcttag ccggaaagaa ggcaaaaact
    13201 atcgtttgcc aacagaagcg gaatgggaat atgcttgtcg ggcaggcaca tacacactat
    13261 tttctacagg agacgggtta cctgcagttt atcatcggaa tcaaaaagtg gttcgtgact
    13321 ttgatccggt atctttaaaa gtagctcaga ctcctcctaa tacattcggg ctttatgata
    13381 tgcatggaaa tgtggaagaa tggtgcttgg attggtatgc tccttattcc gcagaaaagc
    13441 agaaagaccc ggcaggacca ttggcaggag agtttcgggt cactagagga gggagtcatc
    13501 acaccccgga gaaatacttg cgaagtgcca atcgactggc tatgctcccg gaagataaac
    13561 attcccaaac cggatttaga attgtggaag cagatactcg tttgaatgta tcgggaacat
    13621 ctgcccctgt cccgttcaat caggaatctg taaaaaatac atctataaaa tggaaaaaag
    13681 tatctgctat cacaccgatg tttctgcctc cgataccatt tgtggtacgt ccggcatgtg
    13741 attcgaatac cccattttat ctgcataatc atcagcctgc agttacgtgg tgtgataatg
    13801 gagatttgct ggcaatatgg ttttctgcaa atgaagagaa tgggagaggg atggtagtac
    13861 tcggttcccg cttgcgtgcc gggcatactg attgggatgt ggcttcttta ttctttaaag
    13921 ttccggatcg gaatatgaca ggaagcgctt tgctcaatga cggaaaagga aaattgtatc
    13981 atatcaatgg aatggaagca tcgggtgact ggcagaatct cgcaatggta ctacgtacca
    14041 gcacagataa cggtgcttca tggagcactc ctaaactgat agctcccgaa cataccaaac
    14101 gtcatcaggt aatagctggt acgattcgca cacgtgaggg atggctggtt caagcctgtg
    14161 atgcgggtcc cggcagtcat gacggggcag ctgttcaaat cagtaaagat ggaggaaaaa
    14221 catggtgcga tccttgggat ggcgctcctt tgccggattt caaagaagga ggaacgggaa
    14281 gtacaatcgc aggtatccat gcgggaattg tacaattagg gaacggaagt ttgatggcta
    14341 tgggacgtgg taatagcata cggaataaag aaggaaaact ccgaatgcca atgagcatat
    14401 cagatgatat gggaaagacc tggaaatata tagcaagcga actccctcct attgacggag
    14461 gtcagcgtct tgttttaatg agactgaatg aaggcccttt attattggtg tcttttacag
    14521 accatccgca acgtacgcct ttggaagaac gtggtctgga atttaaagat aaaaatggaa
    14581 atgtgaagaa aggatatggc atgtatgcgg ctctttccta cgatgaggga aaaacatggc
    14641 cggtaagaaa actactgacg gacggtgaat atcgcttttt aaacggtgga gcatggacgg
    14701 gatatttcga aatggatgaa aatcatgctg aaccacgtgg ctatcttgca ggaacacaaa
    14761 ctcctgataa tgtggttcat atccttagta gccgattgca ttaccgcttc aatttggcct
    14821 ggctcgaaaa ataaaataaa aaaagtttgt ttttgctgtc cttttccaat tacttcagtt
    14881 gtattataag tgtaattaca attaaaagat aagattttga aagaaaatat ggaaaatatg
    14941 agtccggaat cattgctccg
//
