LOCUS       gnlProkkaNNFBEOCP_3    14295 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNFBEOCP_3.
ACCESSION   gnlProkkaNNFBEOCP_3
VERSION     gnlProkkaNNFBEOCP_3
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 04:24:54
            Original ID  :: gnl|Prokka|NNFBEOCP_3
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3521
            Orig. end    :: 17816
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14295
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9295]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9295
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14295
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14295
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(686..1390)
                     /locus_tag="ctg3_6"
                     /transl_table=11
                     /translation="MNIENSRIYFFLRNSVLYGMLQPIWRFYYRRCRKRAMKLYACELL
                     ENMKQILDKNNILFWLDFGTLLGAYRDKDFISYDCDIDIAILYEDAERVRNLLKNSDFC
                     LTHEYRVGKAGEVAQLSYKYKSLSIDICFYHKKNESMYCYLCSILPGVSIVNNRRCVVA
                     VAKCVVPCEKFADINFHKLIYHAPFPTEEYLAAHYGPNFMIPDSKFDYTKDAPNITNYA
                     IEELAGECIYND"
     CDS             complement(1460..2698)
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MPQIIFILGILIYRFFLDNVYIQTIAPFYAYQGLDYVGTNIDYWI
                     SWGVLIAFSLLMSLLLKYKEFFLSNILILLFLIRFVPFTSLLACKSLDNRLLLMELIYW
                     GAIFLFSLILKRPCLHFSFPKRYKLSTLRFSVVDIVLVFSVLIVLFVSGCYAHFRLNFS
                     LMNVYDLREEARDFSMPVLLKYLWSATGNVLPVLFVYYLIIKRRIVCCFIAFVILLNFS
                     VDGLKANIFKLFLCLLLHLVYKQNLIKMFPWLFALLCFFSLAEYYVFSTPLLSEFVVRR
                     VLYIPALLDSYYFDYISKYGPVFYQRGDVHIDFIIGEEYFGKASMRANNGLFTDAYMNL
                     GEIGCLVYPFVYVAFFKFCESSFEGVNVELVMFVIIIMVITLNSSEFTTSLLTHGLFAL
                     CLLLYFLPRKRYD"
     CDS             complement(2701..3603)
                     /gene_functions="resistance (resist) AAC3 (Score: 59.5;
                     E-value: 1.6e-18)"
                     /gene_kind="resistance"
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MFVEKIRIRILLVRWIKTIFHISDLNLFLRDVRLYSSKLVYCKKF
                     TVVDLVNLMCEMGMKPGSTIVIHCAMKQFYNFSGTAEELIDAIIEKLGPEGTLCMPSYP
                     FDKKNENILFDVIKSPTAAGYLAETFRKRKGVKRSLNKLHSVCAFGKYADYLINEHHLS
                     KTCFDEKSPYYKLAKLNGLSFSLGLPKYYIGTIEHVCESLLCNELGFFRDCFLKEVNFR
                     YKDENQLEIYHKMWTCDRLYLRAHNSKLIDTYFDKEKFSRKRISNLRVSMFDVGYTVDR
                     LVDLAMQGKTLYSYPKFYK"
     CDS             complement(3606..4970)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_9"
                     /sec_met_domain="Polysacc_synt (E-value: 1e-14, bitscore:
                     46.5, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVVFNSNKFFCWINQALITCVSRIICVIETLVPSKFSDKIRILR
                     SHEVVFYNVIGLTFFNSLGGLLTILTQVKLANVMGASHYGVYSYCLAIGEVGAMVVRYG
                     RHKTMVRDLIQYPVRNLQLISSTFIIGVINFLIFLGLVLVFHQDIDIQISVGTVLLICG
                     ACLISLDFQPVYESLNAMSWHSMYNLFQKLIFVIILWGIMLSPFTLSLNVLGIVFFFSW
                     ILVIVWQYKEITSFFHLKIISTCEWSKLFKLYRENFVVAFSCLFGIAFGPIIRIVLNNY
                     CNSREVGVFSAGLQILLIAQFILNQIGRIGNPMMAIIGKDNCSMKQRRLFVYRYLFIML
                     SSTLPFFIPFFFFPSLVVNMFFTEEYADLVIMLPILAVYLIALSVGVVYTQFLISMRKD
                     RLYFIIYVLGATLTILCAFLLIPILGILGATLSLCVPHALTCLCYWWFSANLLRK"
     CDS             complement(5001..6110)
                     /NRPS_PKS="Domain: Aminotran_5 (30-298). E-value: 6.3e-34.
                     Score: 109.3. Matches aSDomain:
                     nrpspksdomains_ctg3_10_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 80.5; E-value:
                     1.9e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_10"
                     /sec_met_domain="Aminotran_5 (E-value: 4.6e-31, bitscore:
                     99.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIERKILLNPGPATTTDTVKLAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGDLSKHTAVLFCGSGTINIDICLNSLLPADKKVLVVNNGAYSTRAVEVCEYY
                     GLPHIDLKFSVYELPDLSVIEKTLSDNPDIALVYTTHHETGTGILNPIREIGKIAHSHG
                     AVFVVDTTSSLGMIPFDIGKDNVDFCMASAQKGLQAMTGLSFIIGDESLIRASRDYPKR
                     SYYCNLYLQYDYFEKTGEMHFTPPVQTVYAARQALDEYFAVGEEAKFARHKRVFEAIHK
                     GLQELGLQYAIKREWQSGLVVSVLYPDDPLWDFDKVHDYCYERGFTIYPGKISTTNTFR
                     LCALGEIDVEDIERFFEVMREAQYLLFIR"
     aSDomain        complement(5217..6020)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg3_10_Aminotran_5.1"
                     /evalue="6.30E-34"
                     /label="ctg3_10_Aminotran_5.1"
                     /locus_tag="ctg3_10"
                     /protein_end="298"
                     /protein_start="30"
                     /score="109.3"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGDLSKHTAVLFCGSGTINIDICL
                     NSLLPADKKVLVVNNGAYSTRAVEVCEYYGLPHIDLKFSVYELPDLSVIEKTLSDNPDI
                     ALVYTTHHETGTGILNPIREIGKIAHSHGAVFVVDTTSSLGMIPFDIGKDNVDFCMASA
                     QKGLQAMTGLSFIIGDESLIRASRDYPKRSYYCNLYLQYDYFEKTGEMHFTPPVQTVYA
                     ARQALDEYFAVGEEAKFARHKRVFEAIHKGLQELGLQYAIKREWQS"
     CDS             complement(6107..7243)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 70.6;
                     E-value: 1.9e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_11"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.7e-22, bitscore:
                     69.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-20, bitscore:
                     64.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSVEKIYDTFLHHGVDFFTGVPDSLLKNICAYITDHAPRGKHII
                     AANEGSAVGIACGYYMASGNVPLVYMQNSGLGNTVNPLLSLADEKVYSLPLLLLVGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMKIPFIILDTDEDEALAQIHDAVVSAKSRSIPHAIV
                     IRKDTFGKYKLRQEALNDYPLSREEALMQVVDHLGDNDIVVSTTGKLSRELFEYRESKG
                     QGHARDFLTVGSMGHSSSIALGIALEKPDRRVYCLDGDGAFIMHMGAVSNIGDLSPKNY
                     RHVLFNNGAHESVGGQPTLGFRLDIASIAKGCGYAHVLTASDKEGLSCALEKLSGLSGP
                     VLLEIKVRIDSRDDLGRPTTTPVENKEHFMAFLKDTHS"
     CDS             complement(7255..8556)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 214.1;
                     E-value: 3.9e-65)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_12"
                     /sec_met_domain="CTP_transf_like (E-value: 7.4e-12,
                     bitscore: 37.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 5.3e-122, bitscore:
                     398.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.7e-64, bitscore:
                     208.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIYVGMTADIMHPGLIHIIHEATKYGDVIVGLLTDKAIAEHK
                     RLPYLTYDQRKEVVENIKGVFEVVPQEDWSYVPNLEKLKPDYIIHGDDWKTGPLREVRE
                     QVFEVMNAQGGKVIEIPYTRGINSSSLDKDIKAIGTTPDVRLKSLRRLIQAKPVVRILE
                     AHDGLCGLIIENLEVQKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKVGLKKNSLFGTDAIQTQDS
                     IEGFCDKIRAGKNAQVTGDFMIIARIESLIAGKPMSDALERAYAYVQAGADGIMIHSKD
                     KSGEDIREFCRTFRKEYAHVPIVVVPTTYDHVHESELHEWGANVVIYANHLLRAAYPAM
                     MNVARTILENERAEEVRPLCMPIKEILELIPGTK"
     CDS             complement(8576..9295)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.5; E-value:
                     3.8e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_13"
                     /sec_met_domain="NTP_transf_3 (E-value: 3.6e-15, bitscore:
                     48.5, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAMIMAAGLGTRFGHYTELVPKGFVEVGGKPMIIRSIETLLS
                     CGIERIILGTGYKKEAYEALQADFPQIETCFSPRYADTNSMYTLYNTRDVIGDDSFLLL
                     ESDLVFERKAILSLLDDEFPDVMLVSSLTKFQDQYYVEYDRNHILTSCSVDKNALEAKG
                     ELVGIHKLSNTFYRRMCADYATILESQPKLGYEYELLRMSRSVSPVRVLRVEGLKWYEI
                     DDEADLSYAEEHIIRYC"
     CDS             complement(9288..10571)
                     /locus_tag="ctg3_14"
                     /transl_table=11
                     /translation="MIRSFLSRSPLYVLALYASVLIFLVYTCAYAYRKPFTAAIYEGEI
                     LWGFDVKILYVLSEIIGYALSKFIGVRILPSMKAGHRIYYIIGLLTFSEVALLGFALLP
                     VPLKVCSIFLSGLPLGMIWGVIFSYIEGRRISEILNVGLSVALIVSSGLVKTLGQFVMD
                     NLHVSEYWMPFTTGLLVYPVMLLCSWLLNQIPAPNEQDIIQRTKRAPMDGKDRRKFLRQ
                     FFWGICMLVVFYGALTVFRELRDSFAADIWKELHIEGAMIFTQTEVPIAVFVLVLMFLI
                     VFVRNNRLALNIIYCIAVTGGSLMVFSTLLYVYGFLSPIWWMILSGLGLYMGYIPFTYL
                     IERLIASLRVVSTAVFIIYLADSFGYLGTTGVFMVKNFVSADISWTVMLMRTALFSGFV
                     SVLSIFAIYCYFKQQLNSLILIPSEIHD"
     CDS             complement(10568..11053)
                     /locus_tag="ctg3_15"
                     /transl_table=11
                     /translation="MLSLQSEIDSLCAVSHELLHLGLDGEPIYSDRFRQLNTDVYHRCE
                     HLFGSHGRTLEEEASLCIALLTGYNATIYNHGDKEDKIQSVLNRSWDLLDTLPASLLKC
                     RLLVACYAEVFDEELAAEAHAIIDGWKDRELTREECEIVEHLKSLEANPYPYSELHE"
     CDS             complement(11112..11543)
                     /locus_tag="ctg3_16"
                     /transl_table=11
                     /translation="MRYEYVFRGERKIRKLVPVVHNLVFVYATRSEVDEMKSTVGASLP
                     IRYIMDRETRQPITIPEVQMRSFIAVAGNYDEQVVYLDPSVVSMKKGDRVRVTGGIFEG
                     VEGEFVRIKGDRRVVVSIQGVMAVATAFIHPSLIELIKN"
     CDS             12739..13086
                     /locus_tag="ctg3_17"
                     /transl_table=11
                     /translation="MKQKKRPASQTEAMKLRWKKRIVFEKGYTEQCAEWMAERLEALTD
                     HLQYGHAAIAYQKQNGDFRLVKATLIYYEAEFHKKYDPTQIEGAVVYWNVDEQRWTTFQ
                     MENFMEWRPIV"
     CDS             13225..14058
                     /locus_tag="ctg3_18"
                     /transl_table=11
                     /translation="MAIAYDGINYFPVGVNFMEENAMEVIEAKYGIKGSAIVLKLLCKI
                     YKEGYFIHWDEEQCLIFANKAGREVQAAEVQGIIEILFIKGILDRNSYLANGILTSANI
                     QKIWMEATKRRKRDLKALPYLLVNDLTQQETEAPEGENVTISPGNVVHDVAVNAKNACN
                     SGQSKVKEKKAEENKELPPSAPPKGKEKEWEEVSAPLPIPGYAFNTMTHNYPGLTDTLK
                     RLGITEAGEVNAILRLSDYGRKGTRVWQLIANTCWSDIGAKGRYLIAALNKAKRK"
ORIGIN
        1 tttatttaaa tattcaacag cctttactac catatgaata tttttatttt taacaaaatc
       61 tcctacatat accaaattaa tttcactgca ttttttttta ttatgggatg ttttataatt
      121 ccgatgcaac aaccaataat catttatgcc attcggcaag acttctgttt tatgttctat
      181 atttttccgt attccagtag gtaatatatt ataaaatttc tttttattag aatctgaaat
      241 caaaaacacc ttacttgcat gctttaatat attatatcct aaagaacgat aaaataaaaa
      301 gtacttaaaa tagaaattta tatctgtatt tctgacggca acaacatacg gtatcgaatg
      361 tcttttccac aattgataag ccacagcccc atcactaaaa agagtatgcg catgaataat
      421 atccacagtc gatattgtta catttgacaa agcatatttt gttatacgat ttactttatg
      481 cttccagaac aagcgttgaa aaccaccagt ttttctaaaa taatacagta cttggactcc
      541 attaacacat tcactaccag atttataata tcctggagca acaacaactt gatcaatgtt
      601 atctttttga attctatcaa acaactcttg atataaagaa tttgtctgat aagcattaca
      661 tatatgtaaa atcttcatct atattttagt cgttatagat acattcacca gctaattctt
      721 ctatagcata attagttatg tttggagcat cctttgtgta atcaaattta gagtcaggta
      781 tcataaaatt gggtccataa tgagcagcca aatactcttc cgttggaaat ggagcatgat
      841 atattaactt atgaaagttt atatctgcaa atttctcaca tggaacaaca catttagcaa
      901 ctgctacaac acatcttcta ttgttcacga ttgaaacacc tggcagaata gagcataaat
      961 aacaatacat agattcattc ttcttatgat aaaaacagat atcaatcgac aaagatttat
     1021 atttataact taactgagcc acttcacctg cttttccaac acgatattca tgagttaaac
     1081 agaaatcaga atttttcaat aaattcctta cacgttctgc atcttcatac aaaattgcaa
     1141 tatcaatatc acaatcatat gaaataaagt ctttatcacg atatgcacct aaaagagttc
     1201 caaaatcaag ccaaaacaaa atattgtttt tatccaatat ttgcttcatg ttttctaata
     1261 actcacaagc atataatttc attgcacgtt ttctacacct tctataatag aagcgccaaa
     1321 taggctgaag cattccataa agcacggaat ttcgaagaaa aaaataaatt ctactatttt
     1381 caatattcat aacaattata ttttatctaa ctaatgttgc acagatagta gcaattacaa
     1441 tttattacaa aacgaccatt tagtcatatc ttttccttgg taagaaataa agtaataaac
     1501 aaagagcaaa taaaccatgc gttaataaag aagtcgtaaa ttcagaacta ttgagagtta
     1561 taaccattat aataatgaca aacatgacta actctacatt tacgccttca aaagacgatt
     1621 cacaaaattt aaaaaaagca acatagacaa atggatagac gagacatcct atctcaccaa
     1681 gattcatata agcatcagta aaaagaccat tattagccct cattgatgct ttaccaaaat
     1741 attcttctcc aattataaaa tcgatgtgta catctccacg ttgataaaaa acaggaccat
     1801 atttcgatat atagtcaaaa taatacgaat caagcaaagc aggtatatat aagaccctac
     1861 gaactacaaa ttcagatagt agaggagtac taaatacata atattcagct aaagagaaga
     1921 aacaaagtaa agcaaaaagc caaggaaaca tttttattaa attctgttta tacactaaat
     1981 gtaaaagcaa acataaaaac aatttaaaga tattagcttt caatccatcg actgaaaaat
     2041 ttaataagat aacaaaagct ataaaacaac atactattct tctttttata atcaaataat
     2101 aaacaaaaag aacaggtaat acatttcctg tagcagacca caaatacttt aagagaactg
     2161 gcatactaaa atcacgtgcc tcctctctta aatcatatac attcatcaaa ctaaagttca
     2221 atctaaaatg ggcatagcaa ccagaaacaa ataaaacaat taaaacagaa aaaacaagta
     2281 caatatcaac tacggaaaat cttagtgtag atagtttata tcttttaggg aaagaaaaat
     2341 gtaaacaagg ccgtttcaaa ataagcgaaa acaaaaaaat agccccccag tatatcaatt
     2401 ccatcaataa caaacgatta tctaatgact tacatgctaa aagtgaagta aatggaacaa
     2461 aacgaatcaa aaataaaaga atcagtatat tagataaaaa aaattcttta tatttcaaaa
     2521 gcaatgacat caataatgaa aaggcaatta acactcccca agaaatccaa tagtctatat
     2581 ttgtgccaac ataatctaat ccctgataag catagaaagg tgctattgtt tgtatataga
     2641 cattatctag aaaaaaacga tagatcaaaa tacctaatat aaaaattatc tgaggcattc
     2701 ttatttataa aattttggat aagaataaag agtcttccct tgcatagcta aatcaacaag
     2761 cctgtcaaca gtataaccaa catcaaacat actaactctc aaatttgaaa ttcgcttccg
     2821 actaaatttt tctttatcaa aataagtatc aattagttta ctattatgtg ctcgaagata
     2881 taaacgatca cacgtccaca ttttatgata aatttctaat tgattttcat ccttatatct
     2941 aaaattaact tctttcaaaa agcaatctcg aaaaaagcct agttcattac ataacaaact
     3001 ctcacaaaca tgttctatgg ttccaatata gtatttaggc aaacccaaac taaaagaaag
     3061 gccattcagt ttagcaagtt tgtaataagg agatttttca tcaaaacacg tcttagataa
     3121 atgatgttca ttaataagat aatcagcata tttaccaaat gcacacactg agtgtaattt
     3181 gttcaaactt cgttttacac cttttcgttt tctaaaagtt tctgctaaat atccagcagc
     3241 tgtaggactc tttataacat caaataatat attttcattc ttcttatcaa atggataaga
     3301 aggcatacat aatgtacctt ctggtcctaa tttttcaata atcgcatcaa ttaactcctc
     3361 tgcagtacct gagaaattat aaaactgctt catagcacaa tgaataacga ttgtagatcc
     3421 tggcttcatt cccatttcac acattaaatt cactaaatcc acaactgtaa attttttaca
     3481 ataaacaagt ttagaactat ataatctaac atcacgcaga aaaagattca aatccgatat
     3541 atgaaatatt gtcttaatcc aacgtaccaa taagatacga attcttattt tttcaacaaa
     3601 cataactact ttcttaacaa gttagcagaa aaccaccaat aacataaaca agttaaagca
     3661 tgaggtacac ataaagataa agtagccccc aatatcccca atataggaat aagaagaaaa
     3721 gcgcacaaaa tagtcaaagt agctcctaaa acatatataa taaaataaag tcgatccttt
     3781 ctcatcgaaa tcaaaaattg agtataaaca actcctacag acaatgctat caaataaaca
     3841 gctaaaatag gtaacattat aactaagtca gcatattctt cagtaaaaaa catattaaca
     3901 actaaagaag gaaaaaagaa aaatggtata aaaaaaggca aagtacttga aagcattata
     3961 aacaaataac gatatacaaa aagtctccgt tgcttcatag aacaattatc ttttccaata
     4021 attgccatca ttgggttacc aatacgtcca atttgattta atataaactg agcaatcaat
     4081 aaaatttgta aacctgcaga gaaaactccc acttcccgtg aattacaata attatttaaa
     4141 acaatacgaa taattggtcc aaaagctatt ccaaaaagac aactaaatgc aactacaaaa
     4201 ttttcacgat acaacttaaa taatttactc cattcacatg tagaaatgat tttcaaatga
     4261 aaaaacgaag ttatttcttt atattgccat acaattacta gtatccaaga aaagaagaat
     4321 actattccta atacattcaa agataaagta aatggagaca gcattattcc ccacaagata
     4381 ataacaaata tcaatttctg aaacaaatta tacatagaat gccaactcat tgcgtttaaa
     4441 gactcatata caggttgaaa atccaatgag atcaaacaag caccgcatat aagcaacact
     4501 gttcctacag aaatttgaat atctatatct tgatgaaaaa caagaactag ccctaaaaaa
     4561 atcaaaaaat taattacccc aataataaat gtggaagaaa taagttgtaa atttctaacc
     4621 ggatattgta taagatctcg taccattgtt ttatgtcgcc catagcgaac taccatagca
     4681 ccaacttctc caatagctaa acaatatgaa tataccccat aatgagaagc tcccattaca
     4741 ttggctagct ttacttgtgt caaaatagtc aataatcctc ccaacgaatt aaagaatgtc
     4801 aatcctatta cattataaaa cacaacctca tgacttctta aaatccttat tttatcacta
     4861 aatttagaag gaaccaaagt ttcaatgaca caaattatcc tactaacgca agtaattaaa
     4921 gcttgattta tccaacaaaa aaatttattt gaattaaaca caacatccat tctaaagaaa
     4981 catttcttcc aatcaacgac ctatcttata aataggagat attgtgcctc cctcatcacc
     5041 tcaaagaacc tctcaatatc ctccacatca atctctccca acgcacaaag ccggaatgta
     5101 ttcgttgtgg aaatcttacc cgggtagatc gtaaagccac gttcatagca gtaatcatga
     5161 accttatcaa aatcccagag gggatcatca ggatacaata cagaaacaac aagacccgac
     5221 tgccattcac gtttgatcgc atactgaaga ccaagctctt gcaaaccttt atggatggct
     5281 tcaaagaccc tcttgtgacg ggcgaattta gcctcttcac ctactgcaaa atattcatca
     5341 agagcctgac gggcagcgta aacggtttga acaggaggag taaaatgcat ctcacccgtc
     5401 ttctcaaagt aatcgtattg taaatagagg ttacaatagt aggagcgttt cggataatcc
     5461 cttgaagcac gtatcaggga ttcatcacct atgataaagg aaagacccgt catggcctga
     5521 aggcctttct gagccgaagc catacaaaag tcaacattat ccttcccgat atcaaaagga
     5581 atcataccca gggaagaagt ggtgtcgaca acaaaaacgg caccgtgcga atgggctatt
     5641 tttccgatct cacggatggg gttcaagata cccgtacccg tttcatggtg cgtggtatag
     5701 accaaagcga tgtccggatt gtcggaaagc gtcttttcga ttaccgacag gtcgggaagt
     5761 tcgtaaacgg aaaacttcaa atcgatatgg ggaagaccgt aatattcgca gacttccacc
     5821 gcacgggtgc tgtaggcacc gttattgaca accagaactt tcttatccgc aggaagaaga
     5881 gagttcaggc agatatcgat attgatcgta cccgagccgc aaaacaggac ggccgtatgt
     5941 ttggagaggt ctccatgcgc aacgcggacc aggtcgtcac gtaactgttt catcataccc
     6001 gcaaactctt tctcacgcgg acagatatcg ggaacaacct gcgccagctt caccgtatcc
     6061 gtcgtggtgg cgggacccgg attcaaaagg atctttcttt cgatattcat gaatgcgtat
     6121 cttttaaaaa tgccataaaa tgctctttat tctctaccgg agtagtcgta gggcgaccca
     6181 gatcatcacg tgaatcgatc cggaccttaa tttcaagaag aaccgggccg gacaggccgg
     6241 acagcttctc aagcgcacac gaaagccctt ccttgtcgga ggcagtcagt acatgcgcat
     6301 aaccgcaacc tttcgctatc gaggcgatat ccagacggaa accgagcgtg ggttgaccgc
     6361 cgacagattc atgcgcaccg ttgttgaaaa ggacgtgcct gtaattcttg ggagaaagat
     6421 cgccgatatt gctgacagca cccatgtgca tgataaaggc accgtcaccg tcaagacagt
     6481 agacacggcg gtcaggcttc tcaagggcaa tccccagggc aatggaagaa ctgtgaccca
     6541 tggaacccac agttaggaaa tcccttgcgt gcccctgccc tttcgattca cggtactcga
     6601 aaagctcacg ggagagcttg cccgtggtgg aaaccacaat gtcattgtcc ccgaggtggt
     6661 cgacaacctg cattagcgcc tcctcgcggg acagaggata gtcattcaag gcttcctgac
     6721 gcaatttata ttttccaaac gtatctttac ggatgacaat cgcatgggga atcgaccggc
     6781 tcttcgccga gacaaccgcg tcatggatct gcgccagggc ctcgtcttca tccgtatcca
     6841 gaattataaa aggaattttc atggctttca gaagatcaag ggtaacctcg ccctgcttct
     6901 tatgctgggg ttcgtctttt gtgccgggct caccgcgcca gccgaccagc aaaagaagag
     6961 gaaggctgta cactttctcg tccgcaaggg acaagagggg attcaccgta tttcccagac
     7021 cggagttctg catataaacc aaaggaacgt tgccagaagc catataataa ccgcaggcaa
     7081 tgcccaccgc ggaaccttca ttggcggcga tgatatgctt accacgcgga gcatgatccg
     7141 tgatataggc gcaaatattc ttcaaaaggg aatcgggaac acccgtaaag aagtcaacac
     7201 cgtgatgaag gaacgtatcg tatatctttt ctacacttac cataaccgtc tgatttattt
     7261 agtgcccgga atcaattcca gaatttcctt gataggcata caaagcggac ggacctcctc
     7321 ggcgcgctcg ttttcaagga tggtcctggc cacgttcatc atggccgggt aagcggcacg
     7381 gagaaggtgg ttggcgtaaa tgactacgtt ggcaccccat tcgtgaagtt cggattcgtg
     7441 cacatggtca taagtcgtcg gaacaacgac aatgggaaca tgggcgtatt ctttgcggaa
     7501 agtccggcag aactcacgga tatcctcacc cgacttatcc ttgctgtgga tcatgatgcc
     7561 gtccgcaccc gcctgtacat aggcataagc acgttcgagg gcgtcactca tgggtttgcc
     7621 ggcaataagg ctttcgatac gcgcaatgat cataaagtca ccggtgacct gggcattctt
     7681 ccctgctctg atcttatcgc agaaaccctc gatactatcc tgagtctgga tagcgtcagt
     7741 accaaaaagg gaattcttct tcagaccgac tttatcttca atgattaccg cagaaatgcc
     7801 gtgacgttcc agagtgcgca cagtaaagac aaagtgttcg atcttgccac ccgtgtctcc
     7861 atcaaaaata ataggcttgg tggtgcattc aaggatattg ttcaggtcct gtaaacgggt
     7921 ggtaaggtcg accgcttcaa tatccggttt acccttactc gtggagtcgg tcaggctgct
     7981 ggaccacatg ccgtcaaaga cctcgcgctt atcacccttc tggacttcaa gattctcaat
     8041 aatcagaccg caaagaccgt cgtgagcctc caggatacgg accacaggct tggcctggat
     8101 caggcggcgg agggacttaa gacgtacgtc aggggtagtc ccgatcgcct tgatatcctt
     8161 gtcgagcgag gaggagttga tgccccgggt ataagggatc tcgattacct tgcccccctg
     8221 ggcgttcatc acctcaaaaa cctgttcgcg cacctcgcgc aacgggcccg ttttccagtc
     8281 gtcgccgtgg atgatatagt caggcttgag tttttccaga ttcggaacat agctccagtc
     8341 ctcctgggga acaacctcaa aaaccccctt gatattctca acaacctcct tacgctgatc
     8401 ataggtaagg taagggaggc gtttgtgttc ggcgatggcc ttgtccgtca gcagaccgac
     8461 gatgacatca ccgtatttag tagcttcatg aataatatgg atcagccccg gatgcatgat
     8521 atccgcggtc ataccgacat agattttctt gttcatatat ggaaaagatt tgtttttaac
     8581 aatagcggat gatgtgctcc tcggcatacg aaaggtcggc ttcatcatcg atttcatacc
     8641 atttaagacc ctccaccctg agcacacgga caggggaaac ggaacgggac atgcggagca
     8701 gttcgtactc gtaacccagt ttaggctggg actccaggat ggtcgcataa tcggcgcaca
     8761 tccggcggta gaaagtattg gaaagtttat ggataccgac cagctcgcct tttgcctcaa
     8821 gggcgttctt gtctaccgaa caggaagtaa ggatgtgatt gcggtcatat tccacataat
     8881 actgatcctg gaacttggtc agagaagaga caagcatcac atccgggaat tcgtcatcca
     8941 gtagcgagag gatggccttg cgttcaaaaa caaggtccga ttcaagcagc aggaaactgt
     9001 catcgcctat cacgtcacgc gtattgtaca gagtgtacat actgttagta tcggcatagc
     9061 ggggactgaa acaggtctct atctggggga aatccgcctg aagggcttca taagcctctt
     9121 ttttataacc cgtaccgagg atgatacgtt cgataccgca ggaaagaagg gtttcgatag
     9181 agcggataat cataggtttt ccaccaacct ccacaaaacc tttgggcaca agctcggtat
     9241 aatgcccgaa gcgggtacca agaccggcag ccatgatcat tgctgtttta atcatgaatt
     9301 tcagagggaa ttaatataag tgaattcaat tgttgcttga aataacagta aatcgcaaaa
     9361 atcgacagga cagaaacaaa tcctgaaaaa agggcagtac gcattagcat gacagtccag
     9421 gaaatgtcag cagaaacgaa gttcttgacc ataaacacac ccgtagtgcc cagatagccg
     9481 aaagaatcgg ccaaataaat aataaaaaca gccgtactaa ccaccctaag ggaagcaatc
     9541 aggcgttcta tcaggtaagt gaaaggaata taccccatat acagaccaag accggaaaga
     9601 atcatccacc aaataggaga aagaaaaccg tacacataaa gcaatgtgga aaaaaccatt
     9661 aaggaaccgc ctgtaacggc aatgcaataa ataatattaa gagccaaacg gttattacgg
     9721 acaaacacaa tcaggaacat cagtacaagg acaaaaacgg caatgggaac ctctgtctga
     9781 gtaaagatca ttgcaccttc aatatggagc tccttccaaa tatcggcagc gaaagagtca
     9841 cgaagctcac ggaacacggt cagggcaccg taaaaaacaa ccagcatgca gattccccag
     9901 aagaattgcc tcaaaaattt acgcctgtct ttaccatcca tcggagcacg tttggtacgc
     9961 tgtatgatat cttgctcatt gggagccgga atctgattga gaagccagct gcaaagcaac
    10021 ataacagggt ataccaacaa accggtggta aaaggcatcc aatattccga cacatgcaaa
    10081 ttatccatca cgaattgtcc caaggttttc accaaaccgg aagagactat caaagcaacg
    10141 ctcagcccga cattcaatat ttcactgata cgacgccctt cgatatagct aaaaatgaca
    10201 ccccagatca tacccagggg aagaccgctc agaaaaatag aacacacctt caaaggaacc
    10261 ggaagaagtg caaaacccaa caaagcaact tcggaaaaag taagcagccc tattatataa
    10321 tagatgcggt gacccgcttt catcgaaggc agaatacgaa caccgatgaa cttggaaagg
    10381 gcgtagccga taatctcaga aaggacatac aggattttga catcgaatcc ccaaagaatc
    10441 tcaccttcat aaatggctgc ggtaaatggc ttacggtagg cataggcaca agtataaacc
    10501 agaaaaatca aaacgctggc atagagagcc aaaacgtaaa ggggagaacg ggaaagaaag
    10561 gaacgaatca ttcgtgtagt tcgctgtacg gatatggatt agcttccaag ctctttaaat
    10621 gctccacaat ctcacactct tccctcgtca attcccgatc cttccaaccg tctattattg
    10681 catgtgcctc cgccgccagc tcttcgtcaa agacctcggc gtaacaagct accaacaaac
    10741 ggcatttcaa aagcgaagcg ggaagtgtat ccaagagatc ccaactacga ttgaggaccg
    10801 actggatttt atcttcctta tcaccgtgat tataaatggt agcattatag ccggtcaaca
    10861 aagcgataca aagagaagct tcctcttcga gggtacgtcc atgtgaaccg aaaagatgct
    10921 cacaacgatg atacacatcc gtattcaact gacggaaacg gtcggagtag atgggttcgc
    10981 catccagacc taaatggaga agttcgtgcg aaacggcgca caaagaatcg atttctgatt
    11041 gcaaagacaa catggtgatt tatttacgta ttggaatatg caccacagag ggcacagagt
    11101 tcacagagtt tttaattctt tattaattcg attaaagagg gatgaatgaa ggccgtggca
    11161 actgccataa ccccctggat ggaaaccacc acacggcggt cacctttgat acggacaaac
    11221 tcaccctcaa ctccctcgaa gatgccaccg gtgacacgga cacggtctcc ctttttcatg
    11281 gaaacgactg aaggatccag ataaacaacc tgttcatcgt aattaccggc aacggcgata
    11341 aaactacgca tttggacttc aggaatggta ataggctgac gggtctcacg gtccatgata
    11401 taacgaatag gaagagaagc cccgacagtg gatttcattt cgtcaacctc actgcgagtg
    11461 gcataaacaa aaaccaagtt gtgaacaaca ggaaccaatt tacggatctt acgctcacca
    11521 cggaatacgt attcatagcg catgggaaga aaattcctca ctccgcggga gtccaggtat
    11581 tccttaaagg caagctcacg gctataggtg atacgaaggg cgtaccagga tttattaatg
    11641 ctattgttca caaaaggata taattggggg acaccggggt agtgaaacac cttccggtca
    11701 agtttgctaa ttctgttgtt tgccttgcag cgtatatcat ttcatcaggt actcccctat
    11761 cgcaggagag acagtttgaa aaagaagaac agaaaacgaa gttttgaaaa aacagggcct
    11821 tactgatctt acaatctgta aacgagtcta ttatgaagcg aaagtgtttc aaaagacgat
    11881 cgtttaattg aacgcaaaga tagagggtat tttcataact gcaaaatgtt taataaaaaa
    11941 aatgttttcc ttcatggctt gatctattta attatttgat aatcaaatgt ctataaacta
    12001 acaaaaaacg ctttaatatc tgtctgcttt tatatgtatt ttaattgtct ggatctttaa
    12061 aaaagtgtgt ttcaaaagac gatcgtttat tgaaacactc acttttttaa gaattatttc
    12121 atttaatgtc agacaattaa gaagagaaaa ggtttcattt tccctttgat tcccacttta
    12181 attccacatt catttgccca ctgaaagatt actctctacc tttgcaacat attaacaaca
    12241 tttagttatt gattaaataa aaaaatcatg aacaaagaaa atgaattatt acagacagtg
    12301 aacaaaagtg taaaaaaacg ctaacactaa aacacaacct cctatcacag aatctattaa
    12361 agaaacaaga ggcagaaaag caggaacgca gataccggga attatctcca acaatgaagg
    12421 agttataaaa gcgctgatag aatcctacat attggacgca aaagaacaaa atatcaagac
    12481 atgtaaagat tcgttggcac gctacataga ggaaaaaaaa ctttttggaa aaataagaaa
    12541 tggagtattc aaaccattag ttttcagcac aatcagaact tacgtcaacg agatctggaa
    12601 taagatggaa agaaagaaaa agaaccaaga aggaaagcgc tgaaatacgt acaatgaatt
    12661 ttatcaaacc ggaatacatt cgatctgacc tatctttggg gcgataattt atctattaac
    12721 cctttaaatc atatacgtat gaaacagaag aaaagaccgg catcacaaac tgaagccatg
    12781 aaactgagat ggaaaaaacg gattgtcttt gaaaaaggat ataccgaaca gtgtgcggaa
    12841 tggatggcgg aacgcctgga agcattgacc gaccacctgc aatacgggca cgcagccatc
    12901 gcttatcaga agcagaacgg agacttcagg ttggtaaaag cgacactgat ctactatgaa
    12961 gcggaattcc acaaaaagta tgatcccaca caaatagaag gcgcagtagt ctactggaat
    13021 gtggatgaac agcgatggac gacattccag atggagaact tcatggagtg gagaccgatc
    13081 gtatagggcg ccaccacaga ttacacggat tttcaccgat gaattatttt tattttgaga
    13141 aatcaagtga agacatcttt gggaatccgg ggtaatttat ggtgaatgta ttattgaaag
    13201 tacaaacgac taatctaaaa aacaatggca atagcatatg acgggatcaa ctatttcccg
    13261 gtgggcgtaa acttcatgga agagaacgca atggaagtga tagaagcaaa atacggaata
    13321 aagggttcgg caatcgtact gaaactactg tgcaaaatat acaaggaggg atacttcatc
    13381 cattgggatg aagaacagtg cctgatcttt gccaacaagg cgggaagaga ggtgcaggcc
    13441 gctgaggtac aggggatcat tgagatcctc ttcatcaaag ggatattgga cagaaacagt
    13501 tatctggcaa acggaatact gacttcggca aacatacaga agatatggat ggaggcaaca
    13561 aagcgaagaa aaagggatct gaaagcattg ccctatctgc tggtgaacga cttgactcag
    13621 caggaaacag aagcgccgga aggtgaaaat gtaaccatta gtccgggaaa tgtagtacat
    13681 gatgtagccg ttaacgcaaa aaatgcatgc aattccggac aaagtaaagt aaaagaaaag
    13741 aaagcagagg aaaataaaga attacccccc tcagctcccc ccaaggggaa ggagaaagaa
    13801 tgggaggagg tttctgctcc cctcccgata cccggatacg ccttcaacac aatgacacac
    13861 aattatccgg gactgacaga tacactcaaa agactgggga ttaccgaagc aggagaggtg
    13921 aatgccatac tcaggctatc ggattatgga aggaaaggaa cacgggtatg gcaactgatt
    13981 gccaatactt gctggagtga cataggggca aaaggaaggt atctgatagc agcactgaat
    14041 aaggcaaaaa gaaaataatc cggataggaa agtacagttt gcagttgata aaaaagcaag
    14101 tataccggtt tccatacgga aggttctctg tcgggaatgg aaaacgggac atacatttaa
    14161 acaaatgatc tacagccact tcagagcaca atatttcaat ctgcagaagc tttattttaa
    14221 cgttacgtta aagttcgttt ttcgtctgca aatagcaaat tctttaaatg caaaagactt
    14281 gttatttgca gacaa
//
