LOCUS       c00063_gnlPro..        13882 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BICKLPPP_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 08:56:25
            Original ID  :: gnl|Prokka|BICKLPPP_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13882
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13882
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4286:8510](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(4287..8510)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13882
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13882
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             107..1864
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_1"
                     /sec_met_domain="Transketolase_C (E-value: 2.7e-17,
                     bitscore: 52.0, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 1.5e-18, bitscore:
                     56.2, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 8.4e-08,
                     bitscore: 20.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLENIYSPADVKKLSFQELNDLSHEIRASLLQKLSAHGGHFGPN
                     FGMVEATIALHYVFNSPKDKIVYDVSHQSYVHKMLTGRKDAFLHPAEYDHVSGYSEPQE
                     SEHDFFVIGHTSTSVSLASGLAKGRDLTGGNENIIAVIGDGSLSGGEAFEGLDYVAELG
                     TNMIIIVNDNQMSIAENHGGLYKNLKDLRDSNGQCECNFFKAMGLDYMYVNDGNCVEAL
                     IEAFSKVKDIQHPIVVHINTLKGKGYEPAEQDKETYHWRTPFDLETGKSKMNDDAEDYS
                     EVTAQYLLKKMKEDKRVVTITSGTPAVLGFTPDRRQEAGKQFVDVGIAEEHAVALASGI
                     AANGGKPVYGVYSTFIQRSYDQLSQDLCINNNPAVLLVFWGTLSGMNDVTHLCFFDIPL
                     ISNIPNMVYLAPTCKEEYLAMLEWSIHQNEHPVAIRVPATDVISCGEPVESDYSNLNRY
                     KVAHRGSKVAILALGSFFGLGQSVLSLLKEKANIDATLINPRYITGVDSELMDELKADH
                     ELVITLEDGVLDGGFGEKIARYYGATDMKVLNYGAKKEFVDRYDIQELLRANHLTDEQI
                     VEDILSLIG"
     CDS             complement(1951..2841)
                     /locus_tag="ctg63_2"
                     /transl_table=11
                     /translation="MVKSRIFDNRQLLKEHPEIPHYKEEVVCFMSEYKDRSYPENERYF
                     NRELYMILVLEGRSEILLNGEFIVIEPDMLLVHGANYLTDHLYSSPDIKFITLSISESM
                     RTDDSYLTQITAILLATMRQNKQYTIQLTAYEAQIIRNELEVLMRLLNIKHQFLFRRIQ
                     AACNALFLDIADFLSRKTIIKKEVSRKDHVLQEFHALVTRNFREEHFVSFYADKLAISE
                     QYLARIVRAGTGKSVNTIINELLIMEARTLLSSTKSTVGDIASRLGFSDAAGFCKFFKR
                     NMGQTPLNYRKGLWI"
     CDS             2998..3669
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="MGMKDVFKRYLVFVIGLYFLAAGIVLIVRSALGTTPISSINYVLS
                     LNSPLSLGTCTFLINMLLILGQFWVIRKNRTRQDTIEILLQLPFSFIFSAFIDFNMALT
                     SNLHPDNYGMSIALLLTGCMIQSIGVVLELKPKVAMMSAEAFVKYASRCYNKEFGKFKV
                     CFDVTLVTLAVILSLLLSQCIEGVREGSLIAACITGYIVSFLNQKIMTRKTLYKLLPVL
                     K"
     CDS             complement(3677..4300)
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MTTTNNNEDLEKKIIEAAKELFIENGFAETSMSDIAAKVGINRPA
                     LHYYFRTKDKMFQAVFGNIILSFIPKIHDIIIQQDKPVSESIGEIVDAYYKVFTENPCL
                     PLFMVREMHRDMNHLSDTIKELRLEQYLHKIMDVLQEEMNDGRLKTVPLPFVFYTFYSA
                     LTVPFLTKNLSASFFLEKDDSFEDILVQWKPYIVRQMETLLVVS"
     CDS             complement(4287..8510)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_5"
                     /sec_met_domain="HGD-D (E-value: 5.4e-29, bitscore: 91.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.3e-35, bitscore:
                     112.2, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIGIDVGSTTAKLVAVDENDNLLFSKYERHNAKAKETILSFLK
                     ELLSEIGDKDISVRITGSIGMGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGED
                     AKVVFFKDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRC
                     GVFCKTDIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPA
                     LRKAFIDYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGN
                     LASTGLEPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDED
                     SRLLYSYYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLH
                     SGIIETIAHYMAAHYLNKDVSFILDIGGQDMKAIFVNNGVIDRMEINEACSSGCGSFLE
                     TFAKSLGYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSV
                     VKNCLYKVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGC
                     ALYAMKHQGESVSLDEIINKAQYSARSLYCKGCDNRCLVIRYEFESGKSYYSGNRCEKV
                     FTNGESSNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCG
                     IQVCLSDPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKG
                     MEQNSYNCPIVTGYSEVIKSVQSEGISVDSPAITFKDRNLLFKQCREYLSGLSVDDRTI
                     QQAFQKAESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLS
                     DMGVNVITDDLVRQMDIPTGDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCG
                     PDAFLVDEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEGDVKD
                     FTTVPVYDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYAN
                     NEVCYPATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTD
                     IPVISISVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAK
                     LRDKYLQLAPEVILRRNIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQ
                     KEIIDWLIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQI
                     DKINETASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNNVVS
                     LQPFGCIANHIVSRGVEKRIKSFYPDINLLSLDFDSGVSDVNITNRMLLFIDNLKNATM
                     NYDNN"
     CDS             complement(8630..11917)
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MKKIIISLALVLTALSSYAITPLWMRDARISPDGKEIVFCYKGDI
                     YKVPVQGGTATQLTTQASYEANPVWSPDGKQIAFASDRNGNFDLFIMSADGGTARRLTY
                     HSASEIPSAFTPDGKFVLFSASIQDPAQSALFPTGAMTELYKVPVTGGRTEQVLATPAE
                     WVCFDKSGKNFLYQDRKGFEDEWRKHHTSSITRDVWLYDASTGKHTNLTNREGEDRNPV
                     YAPDGNSVYFLSERNGGSFNVYNFALNTPQEVKAITTFRTHPVRFLSISDKGTLCYTYD
                     GELYTQEPNARPKKVNVDLVRDDEKEIATLRFSQGATSASVSPDGKQVAFIVRGDVFVT
                     STDYATTKQITNTPAKESGVSFAPDNRTLVYASERTGNWQLYTAKIARKEEANFPNATL
                     IEEEVLLPSKTVERAYPQYSPDGKELAFIEDRNRLMVLNLKTKKVRQVTDGSTWYNTGG
                     GFDYEWSPDGKWFTLEFIGNRHDPYSDIGIVSAQGGTITNLTNSGYISGSPRWVLDGNA
                     ILFQTERYGMRAHASWGSQQDVMLVFLNQDAYDRYRLSKEDFELLKEFEKEQKKAKEKD
                     GDKKKDGSKSKKEKADKEGDKEDTEEDKADKKDIVVELSGIEDRIVRLTPNSSDLGSAI
                     LSKDGENLYYFSAFEEGYDLWKINLREKDTKRLHKLNSGWSSLMLDKKGDIFLLGSRNM
                     QKMDAKSDALKSISYQAEMKMDLAAEREAMFDHVYKQHQKRFYNLNMHGVDWDAMTAAY
                     RKFLPHIDNNYDFAELLSEWLGELNVSHTGGRYSPRGNGDVTSNLGLLFDWNYLGKGMQ
                     IAEIVEKGPFDHSRTKVKAGCIIEKINGEEITPDKDITDLLNNKAGKKTLVSLYNPQNK
                     ERWEEVVKPVTSGQLNGLLYKRWVKQRAEDVEKWSGGRLGYVHIQSMGDGSFRTVYSDI
                     LGKYNNCDGIVIDTRFNGGGRLHEDIEILFSGQKYFTQVVRGREACDMPSRRWNKPSIM
                     LQCEANYSNAHGTPWVYKHQNIGKLVGMPVPGTMTSVSWETLQDPSLVFGIPIIGYRLP
                     DGSYLENTQLEPDIKVANSPETVVKGEDTQLKMAVDELLKEIDSRKK"
     CDS             complement(11985..12911)
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MNFKDCIDSYPFILMEGALGERLKREFDLDISGTVAMADLVYQQK
                     GRLALETLWNEYIDIAYRYQLPFLATTPTRRANKERIYMAGYNESIIADNVDFLRSIKE
                     AANVDMYIGGLMGCKGDAYTGEEALNLEEAIDFHSWQAGLFKSAKVDFLYAGIMPVLTE
                     AIGMAVAMSDTDIPYIISFTIQRDGKLIDGHTIDDAIHCIDNHVSNKPMCYMTNCVHPD
                     IVYEALSHKFNQTQTVKSRFWGIQANTSQLSYKELDGANHLHTSSAADLSEAILKLKSD
                     CHLKIFGGCCGTDSSHMEKIAKISEVT"
     CDS             complement(12954..13775)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MNYKITTLVENCVYGRKLQAEHGLSLYIETPENRLLFDTGASDLF
                     IRNARLLNIDLQKVDYLVLSHGHSDHTGGLRHFLELNAEATVVCKREVFFPKFKDEREN
                     GMKYTRSLDLSRFRFIDELTELVPGVFLFPSVDIIDPKDTHFERFWIQKEDGSRVPDTF
                     PDELAMVLVEPEGLSILSACSHRGITNILRTVRTAFPELPCNLLLGGFHIHNAEESKYQ
                     VIADYLHEYLPQKIGVCHCTGVDKYAFFYKDFGDRIFYNHTGKLIQTDSLL"
ORIGIN
        1 atataggtaa aagaatccgt aattcatata caaacagatt tcaaatccgt cagtatcttt
       61 gcagtgaaat aaaaatatag gtataaacat aaaaaaacaa attgatatgt atttagaaaa
      121 tatttactct cccgcagacg taaagaagtt atcgtttcag gaactgaatg atttaagtca
      181 tgaaatccgt gcatcactct tacaaaaact gagtgcacac ggtgggcact tcggccctaa
      241 cttcggaatg gtagaagcaa ccattgccct gcactatgtt ttcaattcgc cgaaagataa
      301 aattgtatat gatgtgtcac atcagagtta tgtacataag atgctaaccg gacgcaaaga
      361 tgcttttctc catcctgctg aatatgatca tgtatccggc tactcagaac cacaggaaag
      421 tgaacatgat ttctttgtga tcggtcatac ttctacttct gtcagcttgg caagcggact
      481 ggcaaaagga cgtgacctga caggcggcaa cgaaaatatc atcgctgtaa taggcgacgg
      541 ttcactaagc ggaggcgaag ccttcgaggg actggactac gtagcagagc tcggtactaa
      601 catgattatt attgtcaatg acaatcagat gtccatcgcc gaaaatcacg gaggcttata
      661 caaaaatctg aaagatttgc gcgacagtaa cggtcaatgt gaatgcaatt tcttcaaagc
      721 gatggggctg gactatatgt acgtgaatga cggcaactgt gtggaagcac tgatcgaggc
      781 tttctccaaa gttaaagata tacagcatcc gatagtagtc cacatcaata cattaaaagg
      841 caaaggttac gaacctgcag aacaggacaa ggagacctat cactggcgta ctccgtttga
      901 tctagaaacc ggaaaatcaa aaatgaacga cgacgcagaa gattatagtg aagtaaccgc
      961 tcaatatctg ctgaaaaaga tgaaagaaga caagcgtgta gttaccatta cttcgggcac
     1021 ccccgctgtt ttgggcttca ctcccgaccg tcgtcaggaa gcaggcaagc agtttgtaga
     1081 tgtcggtatt gccgaagagc atgcagtggc acttgcttcc ggtatcgcag ccaatggcgg
     1141 aaaaccggtt tacggagtgt acagcacctt tatacaacgt tcttacgacc agctatcgca
     1201 agacctctgc atcaataata atccggcagt tctgttggta ttctggggga cgttatccgg
     1261 tatgaatgat gtaactcacc tctgtttctt cgatattcca cttatcagca atatccccaa
     1321 tatggtctat ctggcaccta cctgtaagga ggaatatctc gccatgctgg aatggagcat
     1381 ccaccaaaat gagcatccgg tagctatccg tgtacctgcc acagatgtaa tcagttgcgg
     1441 tgaaccggtg gaatccgact atagcaatct caatcgttat aaagtcgccc accgtggctc
     1501 caaagtagca atccttgcat taggctcctt cttcggatta gggcaatcgg ttctgtcact
     1561 gctgaaagaa aaagccaaca ttgatgccac ccttatcaat ccccgctaca tcacaggtgt
     1621 ggacagcgaa ctgatggacg aactgaaagc cgaccacgaa ttagtgatta cactggaaga
     1681 cggagttctg gatggtggtt tcggtgaaaa gattgcccgt tactatggcg ctacagatat
     1741 gaaagtgctc aactacggag ctaaaaaaga atttgtagac cgttatgata tacaggaact
     1801 gcttcgtgcc aaccatctga cggatgaaca gatcgtagaa gatatcctat cactcattgg
     1861 ctgataagtc aaaaccagtt cattatatat ttcatgtagg ttgatgtatc cgttcgttat
     1921 gggatcacat caacctacat tcattttcac ttaaatccat aatcccttcc gataattgag
     1981 aggagtctgc cccatattcc tcttgaaaaa cttacagaaa ccggcagcat cactaaagcc
     2041 aagccgggaa gcaatatccc ctaccgtaga ttttgtggaa ctcagcaagg tacgggcttc
     2101 catgatcagt aactcattaa taatcgtatt cacacttttt cccgttccgg cacgaacgat
     2161 acgtgcaagg tactgctcac tgatggccaa cttatccgca tagaaactaa cgaaatgctc
     2221 ttctctgaaa tttcgggtaa caagcgcatg aaattcctgt aaaacatggt ctttacgact
     2281 gacctccttt tttatgatag tcttacggga aagaaaatcg gctatatcca aaaacaaggc
     2341 attgcaagcc gcctgtattc gccggaaaag aaactgatgt tttatattca gcaaacgcat
     2401 caacacttcc agttcattac gaatgatttg agcttcgtat gcggtcagct gtatggtata
     2461 ttgcttattc tgcctcatcg ttgccaacag aatagccgtt atctgggtaa gataagagtc
     2521 atctgtccgc atggactcgg aaatggagag ggtgataaac ttaatatccg gactcgaata
     2581 aagatgatcg gtgagataat tcgctccatg aacaagcaac atatcaggct ctatcacaat
     2641 aaattcccca ttcagcaaaa tctcggaacg accttcaaga acgagtatca tataaagttc
     2701 acgattaaag taacgttcgt tttccggata gctcctgtcc ttatattcac tcataaagca
     2761 gactacttcc tctttataat gaggaatttc cggatgttcc tttaacaact gcctattatc
     2821 aaaaatacga gattttacca tttatacctc cttcttttcg acgtaaaaat acaatttgtt
     2881 tcggatatga caaaaactgt gtggaatcgg ataacttata tcagacgaaa aaacgggacc
     2941 tttgcatatt cttctttata gaatgaagaa aaatacgatt atataagata gtaagatatg
     3001 ggaatgaaag acgtttttaa aaggtatttg gtatttgtta tcggattgta ttttctggct
     3061 gccggaatag tgttgattgt gcgttctgca ttaggaacca cacctatatc cagcatcaat
     3121 tatgtgttaa gcctgaacag ccctttatca ttaggaactt gtacgtttct gatcaatatg
     3181 ctgcttatcc tgggacagtt ctgggtcatc agaaaaaata ggacccgaca ggacaccatt
     3241 gaaatactcc ttcaattgcc gttctctttt atcttttcgg cattcattga ttttaatatg
     3301 gcgctcacca gtaatctgca tcccgacaat tacgggatgt caatagcctt attactcaca
     3361 ggatgcatga tacaatccat aggagtcgta ctcgaactca aacccaaagt agcaatgatg
     3421 agcgcagagg cttttgtaaa atacgcctcc cgctgttata acaaagagtt tggaaagttc
     3481 aaagtctgtt ttgatgttac gctggtcact ctggcagtca tactctctct cctgctttca
     3541 caatgcatcg aaggtgttcg cgaggggtct cttatcgccg cctgcatcac cggatatatc
     3601 gtcagcttcc tgaatcagaa aataatgaca aggaagactc tctacaaatt attacctgta
     3661 ttgaaataag ttttctctag ctcactacca gcaacgtttc catctgcctg acgatataag
     3721 gtttccactg aaccagaata tcctcaaaag aatcatcctt ctccaaaaag aaagaagcac
     3781 tgagattctt tgtcaggaaa ggaactgtca atgcactata aaaagtatag aatacgaatg
     3841 gcaaaggaac tgttttcagt ctcccgtcat tcatttcttc ctgtaaaaca tccatgattt
     3901 tatggagata ttgttccagg cgcaactcct tgatagtatc gcttaaatga ttcatatcac
     3961 gatgcatctc cctcaccatg aacaatggca aacatggatt ttccgtgaat actttataat
     4021 aagcatctac aatttcaccg atactctcgg agacaggttt gtcctgctga atgattatat
     4081 catgtatttt gggaataaaa gaaagtatga tgttaccaaa aacggcctga aacatcttat
     4141 ccttcgtccg gaaataatag tgaagtgccg gtctgttgat acctacttta gcagcgatat
     4201 cactcatact ggtttctgcg aacccattct ctataaatag ttctttggca gcctcaatta
     4261 tctttttctc caaatcttca ttattattag ttgttgtcat aattcattgt cgcatttttc
     4321 agattatcaa taaacaaaag catacggttt gttatgttta cgtcgctcac accactatca
     4381 aagtctaaag atagcaaatt tatatccgga tagaaacttt ttatacgttt ttcgactcct
     4441 ctggatacga tatgattcgc tatgcagcca aaaggttgca aactcactac attgttcacc
     4501 ccttgccggg cgtaagacac gatttcagcc ggcaacaacc agccttcacc gaattgggca
     4561 ttcagcgaaa taacgctttt agctccttcc gcttcttcaa agatatcatt gaagggggca
     4621 aagtaacgga acttacttgc tgtctcattt attttatcaa tctgtttctt tacaaacttg
     4681 tagatccagt cgtaaataaa ctcaggcaac tgtctgtttt ttatgtaaga atccgtattg
     4741 actttcctgt tcacaaaccc ctgcatgaaa aagtcagcca gaatcggcgg aaccacttct
     4801 atcttgcggc ctatcagcca atcaatgatc tctttttgtg cgaaaggatt gaatttcaag
     4861 aagatttctc ctacaattcc gactttagga gtatctacag ccctacacac ctcattaaat
     4921 tcagtgattg ccgattgcaa caaagagttc aaccccttta tgtttcttct cagtatcact
     4981 tcaggtgcca gttgcaggta tttatcacgc agctttgccg atgcacctgc ttctttctca
     5041 cgtaccacag acgcataata aaacttagca atgcaatcac tatacaaaac ggcatgaaaa
     5101 gttatcggta ctactttcat ccagttgacc ttgaacgcgg gctggtcatt atctatgtca
     5161 ctgcccacag agatagagat taccggaata tccgtatatc cggcatccac caacgccttt
     5221 tttatcaagg aaatatagtt gctggcacgg cattgtcctc ccgtttgggt gatggctacg
     5281 gctatttttg aaatatcata tttcccgctt ttaagtgctt ttataatatc gccgactatc
     5341 agagtagccg gataacagac ctcattattc gcatacttca gcccccattc acttgaatca
     5401 ttatcactga gaggaaggtt ttccgcatca taaccggcta ctttcataat agcaggaatc
     5461 aaaggtgaaa tgaacggagt aaagtaagga accagtatct tacggtcacg gtaagacttg
     5521 tcatagacag gaacggtcgt aaagtccttt acatcgcctt ccgttccatc cgcattcgca
     5581 agtttgaggc tttcaatcat ggaacgtact ctcaacttca ttgaaccgat attattgata
     5641 tcatccagtt tcaataaagt cagcgatttg ttatgacgca tcagcaaatc ccttacttca
     5701 tccaccagaa aagcatccgg tccacatccg aacgaagtca tctctacaaa ctgaatattc
     5761 tttccttgtg tcgcacacca tttcgcagcc ttcaggatac ggttcgtata cgcccattga
     5821 gcaacaaaat gcgcatcacc cgtcggtata tccatctgac gcaccaaatc atccgttatc
     5881 acattcactc ccatatccga aagcatatcc gagactttgt gctgtatcag agaatcggta
     5941 tgataaggac gtccggcaag catgacagtc agagtctctc cctttccagt ctgctgcaat
     6001 atgtttttgt tataatcgac caatgtatta ataaaagagt gctgttcgct ttccgctttt
     6061 tggaatgctt gctgaatcgt ccgatcgtcc acgctcaaac cgctcagata ttcacggcat
     6121 tgtttaaaca acagattccg gtctttgaaa gttattgcag gggaatcaac cgatatacct
     6181 tcggactgca cacttttgat aacctccgaa taacctgtca caatcggaca attataactg
     6241 ttttgttcca tcccttttct ttcgaaaata acaaaaggca taaaaatccg gtcgaccttc
     6301 ttttctatca agtcctgaac atgactatgt accagcttag ccggaaagca gatattgtcc
     6361 gacatcacca tacgcgcatt gtgctcatac tttctgaaat tggacggatc agacaaacag
     6421 acttgtatgc cacaggaagt gaaaagagtg tgccagaatg gatattcctc gtacatattc
     6481 agacatcggg ggattccgat aatctgctcg ggtgctgcaa tctctgcgct gcgatgaaac
     6541 aaaagctctt ctttttgccg atagacattc agacctttcc ggttactgct ctctccattc
     6601 gtgaaaactt tctcgcacct gtttcccgaa tagtaacttt tgccgctttc gaactcgtaa
     6661 cgaatgacca gacaacgatt atcgcaaccc ttgcaatata aagaacgtgc cgaatattga
     6721 gctttattga taatctcatc caatgatacg gactccccct gatgtttcat cgcatataat
     6781 gcacatccga atgctcccat caattcgggt gtatcacacc ttgccacttc cgctcccgag
     6841 agaagttcaa tggcacggac caccgcatca ttgcgcatgg tgcctccctg cacaacaata
     6901 tcttttccca aaacagatat atctttcagt ttcagcacct tatacaggca attcttgaca
     6961 acggaatatg ccagtccggc ggcaatatca ttgatcgttg ccccctccct gagtacctgt
     7021 ttcacttttg agttcataaa aacggtgcac cttgttccca aatcacacgg tgcttccgaa
     7081 tggcaggctg ccagagaaaa ctcttgtgcc gaatacccca gagatttagc aaacgtttca
     7141 agaaaagaac cacatccgga agagcatgct tcattaatct ccatccggtc aatcacacca
     7201 ttattcacaa aaatagcctt catatcctgt ccgccgatat cgaggataaa agacacatcc
     7261 ttgttcagat aatgcgctgc catataatgg gcgatcgttt cgataatccc cgaatgaagc
     7321 tgaaaggcag acctgataag gtcttcccca tatccggtag aacagcttcc ttttatattg
     7381 agtacggcat tctgcttcaa acattcatcg ttcaactgat tcagcccctc ttccacagct
     7441 tttatcggat tgccgccatt aatattataa taagaataca gaagccttga atcttcatcc
     7501 agtacaacaa tctttgtcgt agtagaacct gaatcgatgc cgataaagac atcctgtgtt
     7561 ccggctttca agccggaaga tatcatctta tgacgggata ttctttcttt ccatgcttca
     7621 tattcttcat tacttgcaaa aacaggttcc aaccctgttg aagcaaggtt accgttaccg
     7681 tttaaagtag tgtcaatctt atcgatcaaa tgggacagtt tacagtaatc ctctttatca
     7741 agatgaaata gagcagcacc tagtgcaggg agcaaagtgc cgttggccgg cagtatgatc
     7801 tctttttcat cgagggacaa ataatcaatg aaggctttcc gcagtgccgg aatgaaggtt
     7861 aacggaccac cgcaaaacaa tacgggagtt gtaatatcgc aaccgtgcgc cagcgtcact
     7921 accgtttgaa ctgctaccgc acgaaagatg gaagccgcaa tattctcacg acttacattt
     7981 ttagctatca gattctgaat atccgtttta cagaaaacgc cacaacggga ggcaatagga
     8041 tatacctgtg tcgcattcat ggcaagttga ttcaattcat caatattcac tcccagtata
     8101 atcgccatct ggtcaataaa agcgcccgtc cctcctgcgc aattgccgtt catacgcaaa
     8161 tcggtcgctt cggcatcctt aaagaagacg actttcgcat cttctcctcc gatgtctatc
     8221 atagaagtca catgagaata atccttttgt atcgctttcg ctgccgcaac aacctcctgt
     8281 acaaacggca acgaacattt ctctgaaatt cccattccga tagagcctgt tatcctcacg
     8341 gaaatatctt tatctccgat ttcagataac agctctttca agaatgatag aattgtctct
     8401 tttgctttcg cattgtgtct ctcgtacttt gaaaataata gattatcatt ttcatcgacg
     8461 gcaactaact tcgccgtcgt tgaacctaca tcaattccta ttttaatcat gttctacact
     8521 atgttcccct tagtttgaca ctattgtcaa acacaaaagt aagaataagt tggacacatc
     8581 atttcaataa gctctttttt tcggttcttt taacacaaac aaacgatgtc tatttcttcc
     8641 ggctatctat ttctttaagc aattcatcta cagccatttt gagttgcgtg tcctctcctt
     8701 tcactaccgt ctccgggctg ttggcaactt tgatatcagg ttccagctga gtattttcca
     8761 gataactgcc atccggtagg cgatagccga tgataggaat cccaaatact aatgaagggt
     8821 cctgcaaagt ttcccaagat acacttgtca tagttcccgg gacaggcata cctaccagtt
     8881 ttccaatgtt ctgatgcttg tacacccacg gagtgccatg cgcattcgaa taattggctt
     8941 cacactgcaa cataatagaa ggcttgttcc agcgacgact tggcatatca caggcttcac
     9001 gtccgcgtac cacctgagtg aaatatttct gaccactgaa aagaatttca atatcttcat
     9061 gcagacgacc gcctccgtta aaacgggtat cgatcacaat tccgtcacag ttattgtatt
     9121 ttcccagaat atccgagtaa acagtacgga aactgccatc tcccatagat tgaatatgaa
     9181 cgtatcccaa acgaccgccg gaccatttct ccacatcctc agcacgttgt ttcacccaac
     9241 gtttatataa taagccatta agctgtccgc ttgtgacagg ttttaccact tcttcccaac
     9301 gttccttatt ctgtgggttg tacagcgaaa ccagtgtttt tttccctgcc ttattattca
     9361 aaagatcagt gatgtcctta tccggagtta tttcttcccc gttgattttt tctataatgc
     9421 accctgcctt tactttggta cgggaatgat cgaacgggcc tttctctacg atttcagcaa
     9481 tctgcatacc ttttcccaga taattccagt caaacaataa gcccagatta gaggttacat
     9541 ccccattgcc cctcggagaa tagcgccctc cggtatgcga aacattcagt tcacctaacc
     9601 attcgctcag taattctgca aaatcatagt tattatcaat atgcggcaga aatttacgat
     9661 aggcagctgt catggcatcc cagtccactc cgtgcatatt aagattgtag aaacgttttt
     9721 gatgttgttt atatacatga tcgaacattg cctcacgttc ggctgccaaa tccattttca
     9781 tttcagcctg ataactgata gatttcagag catctgactt tgcgtccatt ttctgcatat
     9841 ttctgcttcc cagcaagaag atatctcctt ttttatccag catcagtgat gaccagccgg
     9901 aattaagttt atggagacgc ttcgtatctt tttcacgaag atttattttc caaaggtcat
     9961 acccctcttc gaaagctgag aagtaataca gattttctcc atcttttgaa agaatggcac
    10021 tacctaaatc agaagagtta ggagtcaggc gtacaatacg gtcctcaata ccgctgagtt
    10081 ccacaacaat atctttcttg tctgccttgt cttcttcggt atcctcctta tctccttctt
    10141 tgtctgcctt ttccttttta gacttacttc cgtccttttt cttatcaccg tctttctcct
    10201 ttgctttctt ctgctccttt tcaaattctt tgagcagttc gaaatcctct ttactcaaac
    10261 gataacggtc gtaagcatcc tgattcaaga ataccagcat cacatcctgt tgtgatcccc
    10321 aggaagcatg cgcacgcata ccataacgtt cggtctgaaa cagaatggca ttcccatcca
    10381 gcacccaacg tggagagccg ctaatataac cgctgttagt cagattagtg atagtacctc
    10441 cctgcgcgct gacaatgccg atatccgaat agggatcatg acgattgccg ataaactcaa
    10501 gcgtaaacca cttgccatcg ggcgaccatt cgtagtcgaa tccgcctcct gtattgtacc
    10561 atgtagaacc gtctgtcacc tgacgtactt ttttggtttt cagattgagt accatcaacc
    10621 ggttacggtc ttcgataaaa gccaattcct taccatccgg agagtattgc gggtaagcac
    10681 gttctacggt tttagagggg agcaatactt cctcttcaat aagagtggcg ttagggaaat
    10741 tcgcctcttc tttacgagct atcttagcgg tataaagttg ccagttgccg gtccgctcgc
    10801 tggcataaac cagtgtacgg ttgtcgggag caaaagatac accggattcc tttgccggag
    10861 tatttgttat ttgcttggtc gtagcataat cggttgaagt cacaaaaaca tcacctcgca
    10921 caataaaagc cacctgcttg ccatccggag acacagaagc agaagtcgca ccctgagaaa
    10981 atctgagagt agcaatctct ttttcatcat cacgcacaag atcaacattt actttcttcg
    11041 ggcgggcatt gggctcttgt gtataaagtt ctccgtcata cgtatagcat aaagttcctt
    11101 tatcgctgat tgacaagaaa cgtaccggat gcgtgcggaa agtggtgatg gctttcactt
    11161 cctgcggagt gttcagggca aagttatata cattaaatga accgccattg cgctcactta
    11221 gaaaatagac cgaattacca tccggtgcat ataccggatt acggtcttct ccttcccgat
    11281 tggtcagatt ggtatgtttt ccggtcgaag catcgtatag ccaaacgtct cttgttatag
    11341 atgaggtatg gtgttttctc cattcatctt caaaaccttt acggtcctga taaaggaagt
    11401 tttttcccga tttatcaaag catacccatt cggcaggagt agccaacact tgttcggtac
    11461 gtcctccggt aaccggaact ttatataatt ccgtcatggc tccggtagga aaaagggcac
    11521 tttgcgcagg gtcctgaatg gaggcggaga aaagtacaaa tttaccatcc ggagtgaaag
    11581 ccgaaggaat ctccgaggca gaatgataag tcaaccgacg tgcagttcct ccatcggcag
    11641 acatgataaa gagatcgaag ttcccattcc ggtcgctggc aaacgcgatt tgtttaccat
    11701 ctggcgacca gacgggatta gcctcataag aagcttgtgt tgttaattgg gtagcggttc
    11761 ccccttgaac ggggactttg taaatgtcgc ctttataaca aaagacgatt tcctttccgt
    11821 ccggtgagat acgtgcatca cgcatccaca aaggggtaat agcatagctg gataatgcag
    11881 tcagtaccag cgctaaagag atgattattt tcttcatatt attgtatgtt tatatattta
    11941 ttctatattc cttgtttcat gagaagaccg tatttctagt tagtttaagt cacttccgat
    12001 attttagcga ttttttccat gtgactgctg tctgttccac aacacccacc aaatatttta
    12061 agatgacaat cagatttcaa ctttaaaata gcttcactca gatcggctgc cgaagaagta
    12121 tgtaaatgat ttgctccatc caattcttta tatgacaatt gggaagtatt tgcttgtata
    12181 ccccaaaagc gagattttac cgtttgtgtt tgattgaact tatgagaaag tgcttcgtaa
    12241 acaatatcag gatgaacaca atttgtcata tagcacatag gtttgttaga cacatgatta
    12301 tcaatgcaat gtatggcatc atcaatggta tgcccatcta tcagttttcc gtctctttga
    12361 atcgtaaagc tgataatata aggaatatcc gtatcagaca tagcgactgc catcccgata
    12421 gcttccgtca atacaggcat aatacctgca tataaaaaat caactttggc agatttaaac
    12481 aaaccggcct gccaactatg gaagtctatt gcctcttcca gatttagagc ctcttcgcca
    12541 gtgtatgcat ctcccttaca tcccatcaaa ccaccgatat acatatctac atttgctgct
    12601 tcttttatgg aacgaagaaa atccacatta tctgcaataa tggattcatt gtatccagcc
    12661 atataaatcc gttctttatt ggcccttctt gttggagttg ttgcaagaaa tggtagttga
    12721 tacctatatg caatatcaat atattcattc catagcgttt ctaatgccag tctacctttc
    12781 tgctgataga ctaagtcagc cattgcaaca gtaccactga tatccaaatc aaactccctt
    12841 tttagtcgct cgcctaaagc accttccatt aatataaagg gataagaatc tatgcagtct
    12901 ttaaaattca tccagtttgt ttttatatat tcttgtttag tcgtcgcaga ttattataac
    12961 agagaatccg tctgaatcaa tttccctgta tggttataaa atattctgtc tccaaaatcc
    13021 ttatagaaga aagcatattt atctactccc gtacaatgac agacacctat cttttgaggt
    13081 aaatattcgt gcaaataatc agcaataacc tgatatttgg attcttctgc attatgaata
    13141 tgaaatccac ctaaaagcaa attacagggg agttccggaa atgccgttct tacagtccgc
    13201 aatatatttg taataccccg gtgggaacag gcacttaaaa tggaaagtcc ttcaggctca
    13261 accagtacca tagctaactc gtccggaaag gtatcgggga ctctagaacc atcttccttt
    13321 tgaatccaaa atcgttcaaa atgtgtatcc ttcgggtcta taatatccac agagggaaaa
    13381 agaaatactc cgggaaccag ttcagtcaac tcatcaataa aacgaaaacg agaaagatca
    13441 agcgagcgtg tatatttcat tccattctca cgttcatcct tgaatttagg aaaaaacact
    13501 tcgcgtttgc agacaaccgt tgcttcggca tttagttcaa gaaaatggcg tagtccaccc
    13561 gtatggtcac tgtgaccatg agataatact aaataatcta ctttttgcaa gtcaatattc
    13621 aataaccggg cgttacggat aaataaatcg gaagctcccg tatcaaaaag taatctgttt
    13681 tccggtgtct caatatagag ggaaagacca tgttctgcct gcaatttacg tccatagaca
    13741 caattttcga caagagtcgt tattttatag ttcatgtggt ttggttcttt atcaaatact
    13801 acgaaataaa aagttctgct acaaaattat aataattcta cggcagaaca agtaatcaat
    13861 caatttaaat cgactgtaag gg
//
