LOCUS       c00298_gnlPro..        16294 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MIOMFPNL_302.
ACCESSION   c00298_gnlPro..
VERSION     c00298_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 04:46:19
            Original ID  :: gnl|Prokka|MIOMFPNL_302
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16294
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..99
                     /locus_tag="ctg298_1"
                     /transl_table=11
                     /translation="SKNNTVKTVFIRTMQSESKSLLSLCYHWISNS"
     protocluster    1..16294
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2736:6294](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2737..6294
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16294
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16294
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(164..751)
                     /locus_tag="ctg298_2"
                     /transl_table=11
                     /translation="VVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVFHTGGSGMYAGND
                     LLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDMMICHFPDEAPVY
                     RIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALEEHRQMSASFPLS
                     VENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             983..1447
                     /locus_tag="ctg298_3"
                     /transl_table=11
                     /translation="MRMLSQNIHIIRRRQLRLTCPQCHQTLPQSRVPTPRRELPVFTVS
                     HFRFRQQGHIHAQKFTLCFQEVRIISRRCKHRTSRFGIPHRKQRQVTRHLSGGSRRHIV
                     RLTACQRHIMLRIEYINRSFRHVKDGFNTLFCKYIQEIIRNLHNKEKLIN"
     CDS             complement(1531..1824)
                     /locus_tag="ctg298_4"
                     /transl_table=11
                     /translation="MFEHLVDQQYFSATFLKLVGEVNKAVTGEIKVVHIDEQTGTVGAE
                     FLFGVLQEESGFSYATCPFDTNQTVTPVDLVHKIAANGGIGVLNEVGVCAIE"
     CDS             complement(1843..2112)
                     /locus_tag="ctg298_5"
                     /transl_table=11
                     /translation="MQVILKIIQRSYFGKYSFGYLFMCTEDFFEAVCPEFHSCLQVQKF
                     TERESAQVITFRNVTQFEVFLFESHDGRTGEDNLQAGETVIAHS"
     CDS             2179..2703
                     /locus_tag="ctg298_6"
                     /transl_table=11
                     /translation="MMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDV
                     QTSRATVMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVL
                     DTFFVNTLWKDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGN
                     QIPLWMFGFLY"
     CDS             2737..6294
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg298_7"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.9e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 2.1e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.9e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 6.9e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.3e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.8e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.3e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6419..6607
                     /locus_tag="ctg298_8"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6618..7478)
                     /locus_tag="ctg298_9"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7506..8336)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg298_10"
                     /sec_met_domain="BPD_transp_1 (E-value: 7.8e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8333..9559)
                     /locus_tag="ctg298_11"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             complement(9887..9988)
                     /locus_tag="ctg298_12"
                     /transl_table=11
                     /translation="VKYSNLFYIYLPVCSILLSDRGILPGNFPYHYK"
     CDS             10032..11318
                     /locus_tag="ctg298_13"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11281..11613)
                     /locus_tag="ctg298_14"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(11641..14262)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 61.7; E-value: 2.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg298_15"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.2e-19, bitscore:
                     61.7, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLI
                     ISANEAAPMTPIVEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLK
                     GKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRR
                     HPKIDAVYAHNDRIAPGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFI
                     YPTNGDKVLQLAMDILEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNG
                     RIGGYLSQVATQQVVLYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKH
                     IHFSFDSMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKIAIRLSSLSKEDKRWIR
                     FTVANTGSMISAEHIRNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQG
                     TVFTVELPVQSCEAVAAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNE
                     DIRSYVHTLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSEL
                     QTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFG
                     DGQTLAKEDVCDMDKDFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTN
                     YSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKR
                     KG"
     CDS             complement(14279..14398)
                     /locus_tag="ctg298_16"
                     /transl_table=11
                     /translation="MDEDDEISEVDAGAVLFNRDDGLPAGYTPFSYWGGSMQR"
     CDS             complement(14727..15953)
                     /locus_tag="ctg298_17"
                     /transl_table=11
                     /translation="MFFSLIVPLFLSLFYKPIAYLCGRSLNNKLKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFRELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
     CDS             complement(15975..16109)
                     /locus_tag="ctg298_18"
                     /transl_table=11
                     /translation="VSKATKLSSFLKEGNLVAFDTSSFLFLISVNIPLPCVLIYYLIC"
ORIGIN
        1 tcaaagaata acacagtaaa aacggtattt atcaggacga tgcagagtga gagcaagtcc
       61 ttgctctcac tctgctacca ctggatctct aacagctaaa acatcgatga ataaagggat
      121 acagacgaac tgttagagca tgagagcaaa agcactatct ttttcactgg gggagagtaa
      181 gcaaaagaaa cgcacgatac cggctttgag gcgtcaccgg tactaacggc aaatatccgg
      241 cacacacccg attattctct acggacaaag ggaacgaagc cgacatctgc cgatgttcct
      301 ccaaagcctg accggctaaa ggataataat caatccgaaa aactccttcc gcatccgcag
      361 ccaaataacg atccgtcaag agccatgcca ccacccccat attcattcgc agattaattt
      421 cgacacaagg atgaatccgg taaacaggcg cttcatccgg aaaatgacaa atcatcatat
      481 ccactcccaa gtatccatga taaaagccac cgaacaaagc tgacaattct tcttccaaac
      541 gagtccgcag cctgataaat tcttcttgtg gcacataagc cgatagtttc tgcagaatct
      601 tctcgtcaga cagcaagtca ttccctgcat acatcccact cccacccgtg tggaagaccg
      661 aatatccggc aaaaacaacc cttcctctcc cgtcagcata aaactccata gcgaaatctt
      721 ccaccttatt atatataggt tcgcctacca ccccaccctg agaagcagcg acacgggcac
      781 accaaccgga aataaaagta gtaaatatgc ctttacacca attcaatcct ttcccgcttc
      841 cggaaagcgg agcttttaac aagcacgctt cccgcccttc gacgaacgca ctgcactccg
      901 ccaaagtact caaataaaaa gattctccac agaagtattc attcaaccgc aacccaggca
      961 acaactttac cgcctgcaga cgatgcgaat gctctctcag aatattcata taatccgcag
     1021 aaggcagctc cgtctgacct gcccccaatg tcatcaaacg cttccgcaaa gcagggtccc
     1081 aaccccacgg agagaacttc cagtctttac cgtcagccac ttccggttcc gtcaacaagg
     1141 ccacatccat gcccaaaagt tcactctttg ttttcaggaa gtccgcatta taagcagacg
     1201 gtgcaagcac cgcacttccc gcttcggcat accacatagg aagcaacgcc aggtcactcg
     1261 ccatctgtcg ggcggaagcc ggcgccatat agttcgtctc accgcttgcc aacgccatat
     1321 catgctccgg attgaatata taaacaggtc ttttcgtcat gtcaaagatg gattcaacac
     1381 attattctgc aaatatatac aggaaataat caggaactta cacaataaag agaaacttat
     1441 aaattaaagc acatttttgc tatctctact ttgcaaatcc taaaaaaagc actatatttg
     1501 ccagccgaaa aacaaagaaa cgaaatggaa tcattctatc gcacacacgc ctacctcgtt
     1561 gagcacacca atgcccccgt tcgccgcgat cttatggacg agatcgactg gagtgaccgt
     1621 ctgattggta tcaaagggac acgtggcgta ggaaaaacca ctttcctcct gcagtacgcc
     1681 aaagagaaat tcggcaccga ccgttcctgt ctgttcatca atatgaacaa cttttatttc
     1741 tccggtcaca gccttgttga cttcgccaac gagtttcaga aacgtggcgg aaaagtactg
     1801 ctgatcgacc aggtgttcaa acatcccgaa tggagcaaag agctacgaat gtgctatgac
     1861 cgtttcccca gcctgaagat tgtcttcacc ggttcttccg tcatgcgact caaagaggaa
     1921 aacctcgaat tgcgtgacat tgcgaaaagt tataacctgc gcggattctc tttccgtgaa
     1981 tttctgaacc tgcagacagg aatgaaattc cgggcataca gcctcgaaga aatcctcagt
     2041 acacatgaac agatagccaa aggagtactt tccaaagtac gaccgctgga ttattttcag
     2101 gattacctgc atcatggttt ctaccctttc ttccttgaaa aacgtaattt ctcggagaat
     2161 ctgctgaaaa caatgaacat gatggtagaa gtggatatct tgctgatcaa acaaattgag
     2221 ctgaaatatc tttcaaagat aaaaaaatta ctatatttgt tggctgtgga cggaccgaaa
     2281 gctccgaacg tgagccaact ggcaagtgac gtacagacat cccgcgctac ggtaatgaac
     2341 tatatcaagt atctggcaga cgcgcgtctg attaatctgg tttacccgaa aggagaagaa
     2401 ttcccaaaga aaccgtcaaa gattatgatg cacaactcta acctgatgta ctccatttat
     2461 ccggtgaaag tggaagaaca ggatgtactc gacacgttct tcgttaacac tttatggaaa
     2521 gaccataagg tacataaagg agataaaaac gtctctttca tggtagacga agtgatgccg
     2581 ttcaaaattt gtgcggaagg tacaaaaata aagaataacc cggacgtgac gtatgcgttg
     2641 caaaaggctg agataggccg cggcaaccaa atacctcttt ggatgttcgg attcttatac
     2701 taaaaagatt tatttactta aatatttaat ttagttatga ctaaacagaa gaaattcatc
     2761 acatgtgatg gtaaccaagc tgcagcacat atctcgtata tgttctctga agtagcagct
     2821 atctacccca tcactccttc ttcgactatg gctgagtacg tagacgaatg ggctgccgca
     2881 ggacgtaaga acatcttcgg cgaaacagta ttggtacagg aaatgcaatc tgaaggtggt
     2941 gctgccggtg cagttcacgg ttctcttcag gctggtgcat tgactactac ttacactgct
     3001 tctcagggtc ttcttttgat gatccctaac atgtacaaga ttgccggtga attcttgcct
     3061 tgtgtattcc acgtttctgc tcgtacactg gcttctcacg cattgtgtat cttcggtgac
     3121 catcaggacg taatgtcagc tcgtcaaacc ggcttcgcta tgttggcaga aggttctgta
     3181 caggaagtta tggatttggc aggtgttgct catctggcta ctatcaaatc acgcgttccg
     3241 ttcatgaact tcttcgatgg tttccgtact tctcacgaaa tccagaagat cgaaatgttg
     3301 gaaaacgacg acctcgctcc gctgatcgac caggaagctt tggctgaatt ccgtgcccgt
     3361 gcactgaatc cgatgaagcc ggttgcccgt ggtatggctg aaaaccccga ccacttcttc
     3421 caacatcgtg aatcatgcaa taactactat gaagcagttc ctgctatcgt agaagaatac
     3481 atgaacgaaa tttccaagat cacaggccgc aaatacggtt tgttcgatta ctacggtgca
     3541 gaagatgcag aacgcgtaat tatcgcaatg ggttctgtaa ctgaagctgc ccgcgaagct
     3601 atcgaccact tggtagcaaa cggcgaaaaa gtaggtatgg ttgccgtaca cttgtatcgt
     3661 ccgttctctg ctaaacactt cctggctgct gtacccaaga ctgcaaagag catcgcagtg
     3721 cttgaccgta caaaagaacc gggtgctaac ggcgaacctc tttaccttga cgttaaagac
     3781 tgcttctatg gcgcagaaaa tgctcctgtt atcgttggcg gtcgctacgg tctgggttca
     3841 aaagatacca ctccggcaca gatcatctct gtattcgaaa acttggctat gccaatgccg
     3901 aagaaccact tcactatcgg tatcgtagac gacgttacgt tcacttctct tcctcagaaa
     3961 gaagaaatcg ctctgggcgg tgaaggtatg ttcgaagcta aattctacgg tctgggtgct
     4021 gacggtactg taggtgccaa caagaactct gttaagatta tcggtgacaa caccgacaaa
     4081 cactgtcagg cttacttctc ttacgactcc aagaagtcgg gtggtttcac ttgttctcac
     4141 ttgcgtttcg gtgatactcc gatccgttct acttacttgg taaatactcc gaacttcgtt
     4201 gcttgtcacg ttcaggctta cctgcacatg tacgacgtaa cacgtggttt gcgtaagaac
     4261 ggttctttct tgctgaatac catctgggaa ggcgaagaac tggctaagaa cctgcctaac
     4321 aaggtgaaga aatactttgc acagaacaac atctctgtat actatatcaa cgcaactcag
     4381 attgcaatgg aaattggttt gggcaaccgt accaatacaa tccttcagtc tgcattcttc
     4441 cgtatcacag gcgtaatccc tgtagatcaa gctgttgaac agatgaagaa attcatcgtt
     4501 aagtcttacg gcaagaaggg tgaagacgtt gttaacaaga actacgctgc tgtagaccgc
     4561 ggtggtgaat acaagactct gactgtcgat cctgcttggg ctaacctgcc ggatgatgca
     4621 aaagcagaaa acaatgatcc tgctttcatc aacgaagtag ttcgtccgat caatgcacag
     4681 gacggtgact tgctgccggt atctgcattc aagggtatcg aagacggtac ttggtatcaa
     4741 ggtacttcca aatacgaaaa acgtggtgta gctgcattcg ttcccgaatg gaatgctgaa
     4801 aactgtattc agtgtaacaa gtgtgcttac gtttgtcctc acgcttctat ccgtccgttc
     4861 gtactcgatg ctgaagagca gaagggtgct aagttcgagc aactgaaagc tgtaggtaaa
     4921 gcattcgatg gtatgacatt ccgtattcag gtagacgttc tcgattgtct gggttgcggt
     4981 aactgtgccg acatctgtcc gggtaatccg aagaagggtg gcaaggcatt gaccatgaaa
     5041 caccttgaaa gccagttggc cgaagctgat aactggactt actgcgctga aaacgtgaag
     5101 agcaaacaac acctggtaga catcaaggct aacgtgaaga actctcagtt cgcaactccg
     5161 ttgtttgagt tctcaggcgc ttgctccggt tgtggtgaaa ctccgtacgt gaaactgatt
     5221 tctcagttgt tcggtgaccg tgaaatggtt gctaacgcta caggatgttc ttctatctac
     5281 tccggttcag ttccttctac tccgtacact atgaacgaaa agggtcacgg tcctgcatgg
     5341 gctaactcct tgttcgaaga cttctgtgaa tttggtctgg gtatggaact ggctaacgaa
     5401 aagatgcgtg cccgtctggt gaaagtaatg aacgaagcta tcgcttctga ttgctgcccg
     5461 gctgaataca aagaagtatt tgctgaatgg atcaacaata tgctggatgc agaaaagact
     5521 aaggaactgg ccgaaaagat cattccgatg gtagaagctg ctaaagataa atgcaaccac
     5581 tgcaagcaaa tcgctgatct gcaacaatat cttgttaaac gcagccaatg gatcatcggt
     5641 ggtgacggtg cttcttatga tatcggttac ggtggtcttg accatgtaat cgcttccggt
     5701 aaggacgtta acatccttgt attggatact gaggtttact ctaacacagg tggtcagtct
     5761 tctaaagcta ctccggtagg cgctatcgct aagtttgctg ctgcaggtaa gcgtgtacgt
     5821 aagaaagacc tcggtctgat ggctactact tacggttatg tatatgttgc tcagattgct
     5881 atgggtgctg accaggctca gactctgaaa gctatccgtg aagctgaagc atatccggga
     5941 ccatcactga tcatcgctta cgctccatgt atcaaccacg gtctgaaagc cggtatgggt
     6001 aagagccagg aagaagaaga aaaggctgtt aagtgcggtt actggcactt gtggcgttac
     6061 aaccctgctt tggaagaaga aggcaagaat ccgttccaac tggatagcaa agaacctaac
     6121 tgggaagact tccaaggttt cttgaagggt gaagttcgtt acgcttctgt aatgaaacaa
     6181 tatcctgctg aagctgaaga actgtttaaa gctgctgaag aaaacgctaa atggcgttac
     6241 aacagctaca aacgtcttgc cagagaaaac tggggagctg atacagctga ataataagta
     6301 gaaatacttt gtacataata aaaggcagga atcctggaaa cagattcctg ccttttttgt
     6361 ttatatctta gaagtaacga ttacttctca cgaagatatt cattaaaact ctaaagatat
     6421 gatcggattt gttatttgga ttatcggttt gatactgact ttcagagctg ccatagagat
     6481 ttggaatata aatgcggctg tagagaaaag acttatagcg attgtattaa tcgttcttac
     6541 cagctggctg ggactacttt tctactactt ctatggtaaa gaaagaatgg cgggatggtt
     6601 gaagtagtgt ttgcatatca atctttctca ggaatccaac tgttcaccag ttcctgatgt
     6661 tcttccatcc attgacgggc agcctgtctt tccgttgtct gcgcctcttc cagagcagtc
     6721 attaaggagc tgatttccgc atctgtcaga cgaatgttgc ccaaaagttc ggcagcaaaa
     6781 gggtccttct cgctaaaacc tttccatgct atggtatgaa tggattccgt atttccatat
     6841 atcagcttcg ggtcctgaag aactttcagc ttgaaacggt cgaacatcca gtgaggcgtc
     6901 catcccgtca cgacaatcca gtctttctta tcaatcgctt tctttaggga agcagtcatg
     6961 gcaggtccgc tcgaagtcat cagtttataa tccaatccat agtctttgat ggcctgatcg
     7021 gtagctttca taataccggc tccggcatca ataccgacaa tctgaccgga gaaacgttcc
     7081 ttttccgcgt tcagttcttc gattgagttg atcgtaacgt aatccggaac caccagcccg
     7141 atacgggcac catcataaat atccccgata acttcgagtt tatccccgta ttgtttcata
     7201 taatcttcca tagtgacagg catccagaca tccataaata cgtctgcttt cttacgggag
     7261 atagaggtaa atataggtgc aaggtcggca ttcagcaact ttacatcgta cccctgatct
     7321 tcaaaaatcg ctttggcaag gtttgtcatt gcaatacctt ccgaccagtt ggcataagcg
     7381 atacttatct tcttactctt tccgttgtct ccgcaggaaa cgaaggttaa gagtatgccg
     7441 gcaataaaca ttgccgcaat catttttatc ttattcattg attattcctt tctttggtgt
     7501 gattcttatt tctttttact ttttctgtta tctgccatac cctgagtgat gcggtccagc
     7561 acgatcgcca atatcacgac tgcgataccg ccttcaaatc cgagtccgat tttcatttgg
     7621 gtgatacctt tcagcacgat ttctcccaat cctccggcag aaatcatggc agcaatcact
     7681 accatcgaaa gtgacatcat gatcgtctgg ttgattcccg tcagaatagt aggcaacgcc
     7741 aaaggcaatt gcaccttata aagaagctgc cagggagtag ctccaaaaga gcgggaggct
     7801 tctactacgt ttttaggaac ctgacgaatg cccagaccgg tcagacgaac cacaggaggc
     7861 attgcaaaga tgatggtggc aaaagctccc ggcacagttc ccaatccgaa gaatagaacg
     7921 gcaggaatca gatagacaaa ggcaggcatt gtctgcataa agtcgaggac agggcgcatt
     7981 atcttgttac aacgatcact gttggcagtc cagattccca acggaacgcc taaaagcaat
     8041 gccagacaag tggaagaaag taccaatgcc aatgtctgca tcgtttcttc ccaaaagccc
     8101 atgccgtaaa taagcaataa acccaagagg gtaaatacgg ctgtcccctt acccgactta
     8161 aaccaggcga gcgcagccag cactgcaatt gtgatataaa aaggtattcc aaacagtacg
     8221 tgctgaaaac cgtctatgaa tcctccgatc cccatgctga gagcatcaaa aaaggaagca
     8281 aaatgttctg tgagccaatt aatggcagtc tctatatatt gtccgatatt tatcataatt
     8341 ctattgcgtt ttgaatgatt tcattaattt cttctttatc ttttcccgtt acttcgatga
     8401 tcaatgagga aagtggcact acgccttcaa actcccgatt ctcatttacg acccagattg
     8461 gcgagttcgt ttttgtcatc aacggaagaa tatcttccag caccgtatca cccagcactg
     8521 aatgaacttc atgccttact acggactcga tggagcggat ttgctctttt cgtagtttca
     8581 gcaagtcatt caaccgcacc tctcctacta acagattatt ggaatcgact accggaagaa
     8641 cggtcagatt ccgttcgcgc atcttacgga tcagcacctc cgggccttct ttcttcaaac
     8701 gtgccactat gggtttatct accataacag aggaagctgt tataatcttg cttcgatcta
     8761 cattctccac aaatcgttct acataagcgt tggcaggttc ggtcaggatt tcttccgatg
     8821 taccgatttg tacaatttct ccatccttca tgatagcaat ccggtcaccc aatttaatcg
     8881 cttcactcag gtcgtgagta ataaagacaa tcgttttttt catcttcgac tgcaaagtca
     8941 gcagttcatc ctgcatctgc acacggatca aaggatcgag tgccgagaag gcctcatcca
     9001 tcaacaggac ttcgggatta ttggccaaag cccgcgccag cccgacacgc tgctgcatcc
     9061 cacccgacag ttcacttacc atctgattct cgtagccttt cagccccacc agttgcatac
     9121 tttccatcgc tttctgctcc cgttctccct tttttactcc ctgtagttcg agcccgaaag
     9181 ctatattatg caagacagaa cggtgaggaa gcagaccgaa gttctgaaag accatagcca
     9241 gttctttccg gcgaatctgc aacagttcct tatccgacac tttggctatg tctgttccat
     9301 tgataatcac ttctccggaa gtagggcgta tcaaacggtt gatgcagcgg agtaaagtgg
     9361 actttccact accggacagc cccataatga cgaatatttc gccttcatta atggaaagat
     9421 tcgcatcttt caccgcaact gtacatccgg tcgctttcaa tatttcactt tttgttttac
     9481 cttctttcaa catcttcaaa gccttctgct tctcattgcc aaaaaccaga tagagatctt
     9541 taatttctat tttactcata caataaaatg gtttaggtta ttaaaataat atacacagca
     9601 agacaagaac aaacgataac aggaatcttt ctttatatcg tataaagttc tgatttaaat
     9661 aagggacaaa taacaatgaa tcccgaaata attaataaaa tgattattga cagactgagt
     9721 aattaaaaaa ggaatagaat ttgataagat aatcctttca acgaatagca aaaaatagca
     9781 tttttatgta taaaaacagc ctgttccagt atcttgctgg cacaaagata caaaaaacgg
     9841 attaaacata caaattatat tcaaaatccg gggcatacag agggctttat ttgtaatgat
     9901 atggaaagtt tccgggtaat attcccctat cactcagcaa aatagaacaa accggcagat
     9961 aaatataaaa taagtttgaa tatttcactt aaacaccgta tatttggcgt caataactaa
    10021 actagattta tatgttcaac agggctatta caattttcct ggggaaggat aattgtcatt
    10081 acacaacaaa agaaaaacaa acaggtactg ccacactaga cgacaaaagc caagtacagt
    10141 tccttagtaa aaagaacccc aaaatgccgt ttttctatag ccggcggaat ctctacatga
    10201 taggtttcct gctcgctttt atagtgactc tgctcgaatt tatacgagga cggcatcaaa
    10261 actttatggt cttctcggac gctactcaat tcttctggca aggcatcagc ccatacacaa
    10321 ctgaatttgt agaagctcac ggacgctact tcctttattc tccagttttc acggtattgt
    10381 tcgctccgtt tgcgtatctg cctgcatggc tgggaccttt cgcgtggaat ctattcaatt
    10441 attcgctgtt ctttatggcg atcttcacgc tgccccaaca attcacccag cagcagaaat
    10501 gccgtatgtt cctttttctg ttactgattt taggacaaag tttactttca tttcagtata
    10561 acataacggt agcctattta ttcttattcg cctatacgtt attggaaaaa gaccgtggat
    10621 ttctggctgt tctgttaatc atgatttcgg gatgtaccaa agtatatgga attttcgaac
    10681 tggcattgtt gctgtgctat cctcacgtat ggcgtaactt tggctatgcc gttacaatgg
    10741 gcattgtatt gcttgcatta ccgttaataa aaatagctcc tgcagatttg ctcccctatt
    10801 atgaagaatg gtgccatagt cttgctgttc atcagtccgc cggagcttat gattcatttt
    10861 tctatgcccg ccccattgca gcatggacat tgccacactt ccgtgcactt cagataggaa
    10921 tgctcggctt gctgactctg ctctttttgg ggaatttccg caaatggtcg tcttttgcct
    10981 tccgtgccca ggctttgggc attctcatgg gctgggtagt attactgagt gactccgccg
    11041 agaagcatac ctatattatc gcattggcag gtttcatgct ctggtattgg agcagaccaa
    11101 cacgtaccgc aacagacaag attctatttt ggtgctgttt tgtgctgtta tgtatcgttc
    11161 ctatcgacat attcgtccct gtacccatca gagatttcat taccaggacc ttatggcttc
    11221 atgtatgggt tttctttatt gtatggatac ggatgatatg gcttaccttc cttgcatcct
    11281 tcattcatcc acgtgccaca aatgttcttt cagattaacg catccgttag ctttgaaaga
    11341 aacttcttct gccagcaaga gttgtttttg ttccacccaa ccgggcacca gccttccggt
    11401 ggaatttaca actctatggc agggaatgga taattcatcc ggcacttctt tcaatgcacg
    11461 tcccaccatc cgcgagcatt ggggtgcccc caacagcaaa gcaatacctc cataagtaga
    11521 tacttttccc acaggtatct gggatacgac ttcgtacact tccttccgaa aggattcgga
    11581 aaagctctct ttatctactt tataatcttt catatatccc tctttacgat atcaatgaaa
    11641 tcatcctttc cttttcagga aatctgtcgg gctctctcca aactgctctt tatagcactt
    11701 ggcgaaataa gaaggtgaac tgaaaccgac ttcataacca atctccgcta cggtcatgtc
    11761 cgaagaagca agcaaagaag ctgccttctt caaacgggcg atacggagca attcattcgg
    11821 agagtagtta gtcaatgatt taatcttgcg ataaagctgc acacggctta gtcccatgtc
    11881 tttgcccaag tcctccacat tcaaaccgga gtctcccatt ttctcttcaa tcaatgactt
    11941 gaatctttct acaaaatcct tgtccatatc gcagacatct tcttttgcca atgtctgccc
    12001 gtcaccaaag aactgtttca gacgacggtg agaatcgatc agattgcgga cacgtgccag
    12061 caacagctgt gaactgaacg gctttgaaat ataagaatcc gcaccaccgt catatccctg
    12121 aatacgctgt tcgtccagtg aacacgctgt cagcagaata accggaatat gacaggtctg
    12181 taactcactt ttcagccggc ggcaacattc aatgccatca atgcccggca tcatcacatc
    12241 agaaatgatc aggtccggaa catacttcat agccttacgg attccttcgg agccgtctgc
    12301 cgcttcaatc accgtatagt ctgtatgcaa cagcgtatgg acatacgaac ggatatcctc
    12361 attatcatca ataatcagta cggacggttt ggaagagtca tatccttttt ccagttcttc
    12421 ctcttctgcc aatagaacat ctgttgtacg ggaatccgca gaaacaaggg tggtatccgg
    12481 ttcggcagca acagcctcac aagactgtac aggcagttca acggtaaaga ccgtgccctg
    12541 tttctcatcg ctctctacgg agatcatacc accgtgcatt tctacgaagg cttttaccaa
    12601 tgccagtccg attcccgaac cggtatggtg catatcaatc ttatagaaac ggtcgaatac
    12661 attgcggata tgttcggcag aaatcatgga accggtattt gccaccgtga aacgtatcca
    12721 tcgcttgtcc tctttactaa gggaagacag acggatggct attttcccgt tttccggtgt
    12781 aaacttaaag gcattggaca ggagattgaa ataaatacgt tccagcttct ccatgtctgc
    12841 cagtgtatga taatccgtat ccggcatact atcaaaagaa aaatggatat gcttcttacg
    12901 ggctgccgcc tgaaaggact cattccatcc ttcgaaagaa gaaaggacat ccaccgtaac
    12961 cggagtatat tccatcttgc cgttttcata tttacggaaa tccaaaatct gattgaccag
    13021 gcgcaaaagg atattcacat ttcgctgaat cagcatgagc atccggtgct gatctccact
    13081 caatgtcttg tccgccaata aatgttctac cgggtcggca accaatgtca acggagtacg
    13141 gaagtcgtga gaaatattgg tgaaaaagac cagcttggca tgggtagctt cttccagttg
    13201 atgagagagc tgtatcaatt ggtcacgctg ttcttccagt ttgtcacgct gctcttccaa
    13261 ttgctgcttc tgcttaaaaa gctctttatt caagcgattc ttagagcgga gtgatttata
    13321 aacgaccaat aataaaccgg ctaccaataa aaggataatc agactgccgt ataaaacaac
    13381 ctgttgtgta gctacctgag agaggtatcc accgatacgt ccgttgagcg tttcaatctt
    13441 tttatcgagt tcggagatgt gtgtagtctg caactgcatg acgtgtgcgt tggtacggtc
    13501 cacaacagcg gtattcatca ccgtttcttt gggatagggt ttcttctcca gaatgtccat
    13561 agccagttgc agtaccttat cgccattggt cggatagata aaggtggcat ccagcacact
    13621 gtccaaaacc agttccagtc cgtttccctt acccggcaag gcatctatgc cgacaaaaat
    13681 catttccttc tcccgccctg ccatctttgc tgcctgatag gcacccggag cgatacggtc
    13741 attatgggca tacacagcat caatcttagg atgcctccga agcatactat ccatttctat
    13801 ctctgccgga ccacgttccc acgcagcatc cgctttatca atcagcttta tatccgggaa
    13861 tttactgatg gcagccataa atccctgatg ccgttccatt gcaggagtcg aaccgctcaa
    13921 tcctgtcagt tctactatat ttcccttccc tttcagactg gaggcaatat agtttcctac
    13981 cgaacgaccg atttcataat tatcggctcc gatataggca gtatatttat ccgaaagaat
    14041 cttccggtct acaagaataa cggggatgcc tttctgataa gcttcttcta caatcggagt
    14101 cataggagca gcttcgttag cggaaataat cagcagatcg actccttcgt ccataaaata
    14161 atggacatct tccgcctgct tactgttatc atctcctgcc gaacggattt ccaccgaaac
    14221 gccattataa aacattgctt cccgaagaat ctcatcattc atcttatgtc gccatgaatc
    14281 atcgctgcat tgagccaccc caatacgaaa acggggtgta tcctgccggc aagccgtcat
    14341 cccgattaaa caaaacagca ccagcatcca cttcagatat ctcatcgtct tcatccatct
    14401 catcatttcg tagttctttc tgtaatccaa ttaagaacaa aaataagaaa taatactgta
    14461 aagttctcta acttcagcta tttattattc taaaaagaag gaaagcagtc ctctttcaga
    14521 ccatcggaaa gtattaacaa aagtataaag cgtaaaacaa acacttaatc aatgttataa
    14581 aacatagcgt tttacttgga taatttgcag atttcacaga agtccgtatc tttgcactgt
    14641 gtttttcata gtattagatt taaggttaac aaaggttgga gcaaggcgtt gctccttttt
    14701 ttatgccctg acctttcatc taccggttag ttttcatccc attccttttc cagtttacca
    14761 tcaatagtgt agcgtttcca tcgtcctaca cggcgaccat tcttatattc cccacattca
    14821 cgaagctggt cattctttac ataacgagct tcgaacggtc cgttctgcct tccgttcaca
    14881 taggtagaag tttcccaata atcaaagcgg ttgctcacta tcagccgtcg ttccttgcca
    14941 tgcaatctgc cggcctgata ggtagcttca tatctcaatt caccattttc cagattatat
    15001 tcacggtata aaccgtcttt acgatcgttc ttcatataat attctttctg ccttacccca
    15061 cttccgttgg caaatgagac atggagtcca tcttcttttc catccagata ggtttcaatc
    15121 atcagcgtat ctccgctttc agcaaaagta gtccaccgac cattcttctt tccattctta
    15181 taactaccca gtatacgtgg cgagccaaac gtaaacacgg acgaatattc accgtcctgc
    15241 aaaccttctt cattgaaata aacggtctca tacaaatcat atgtaccttt cagaaaagta
    15301 tactgtttgc ctacctgctt cccgtccttg taattatgct ctttccgcaa agtaccgtca
    15361 gattcgtacg acagttgctt cccgtgctct ttccccatcc ggaagtttct ttcactttcc
    15421 acttttccgg tagtaaagta acttttgctc gtaccgtcca gcttaccttc cttataggac
    15481 ttttcttctt tcagcttacc gtcaaacttg gagttaatct tgaagaggcc atccttccgc
    15541 ccttctttat aacttccttc cgttattaat atattgtcca catattcttt gtatccgcca
    15601 tcataaaaac catctttaaa agatgccagc acataggcgg aatgataacc atctatgatg
    15661 cgatgttcgc cattcaatgc tttttccgtt ttcagttccc gaaacaacag tctgccatcg
    15721 cctacattga caacggatac ctgatcgatc ttatattcct tttgcgcaaa caaaggaaga
    15781 gcaagatata aaaacaaaaa tacgttccag ctttttgatc tgaggaagtt tgaaatgtgt
    15841 ttcataaagt agttttctct ttttaattta ttatttaaag acctgccgca aagataggca
    15901 atcggcttat aaaacaagga aagaaagagg gggacaatta gagaaaagaa catctgttat
    15961 tatcattcta ataattaaca gattaagtag taaatcaaaa cacagggaag ggggatattt
    16021 actgaaataa gaaacagaaa agaagatgtg tcaaaagcaa ctaaattccc ctccttcagg
    16081 aaggaggaga gtttagttgc ttttgacaca ccttcttttt gaatttaaag agattctaca
    16141 acaatctgtc tttcagaata accggaagtt cgggcattgc accgctctgc gtacaaacat
    16201 aagcggaaac ttcgacagcc agcttatgag cttcgggaac agacttgcca ttcagaatgg
    16261 aagcacagaa agcggcagta aaggaatccc ccgc
//
