LOCUS       c00018_gnlPro..        16076 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EOAKPANP_18.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 05:33:55
            Original ID  :: gnl|Prokka|EOAKPANP_18
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16076
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16076
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9856:13414](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(9857..13414)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16076
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16076
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             197..1423
                     /locus_tag="ctg18_1"
                     /transl_table=11
                     /translation="MFFFLIVPLFFALFYKPIAYLCGRSLNNKLKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFRELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
     CDS             1756..4509
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_2"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFCLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAIRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFTKCYKEQFGESPTDFLKRKG"
     CDS             4537..4869
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSIGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(4832..6118)
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRQNLYMIGFLLAFIVTLLEFMRGRHQNFRVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFVAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLFIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVAMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSTGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             6592..7818
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             7815..8645
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             8673..9533
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTMERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(9544..9732)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(9857..13414)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_9"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             complement(13448..14653)
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             14833..15987
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
ORIGIN
        1 cttatatttt gttgtgatat ttaatactgc aaatgtaaat gtgtcaaaag taactaaact
       61 ctcctccttc ctgaaggagg ggaatttagt tacttttgac acaccttcat ttctgtttct
      121 tatttcagta aatgtccccc ttccctgtgt tttgatttac tacttaatct gttaattatt
      181 agaatgataa taacagatgt tcttttttct aattgtcccc ctcttctttg ccttgtttta
      241 taagccgatt gcctatcttt gcggcaggtc tttaaataat aaattaaaaa gagaaaacta
      301 ctttatgaaa cacatttcaa acttcctcag atcaaaaagc tggaacgtat ttttgttttt
      361 atatcttgct cttcctttgt ttgcgcaaaa ggaatataag atcgatcagg tatccgttgt
      421 caatgtaggc gatggcagac tgttgtttcg ggaactgaaa acggaaaaag cattgaatgg
      481 cgaacatcgc atcatagatg gttatcattc cgcctatgtg ctggcatctt ttaaagatgg
      541 tttttatgat ggcggataca aagaatatgt ggacaatata ttaataacgg aaggaagtta
      601 taaagaaggg cggaaggatg gcctcttcaa gattaactcc aagtttgacg gtaagctgaa
      661 agaagaaaag tcctataagg aaggtaagct ggacggtacg agcaaaagtt actttactac
      721 cggaaaagtg gaaagtgaaa gaaacttccg gatggggaaa gagcacggga agcaactgtc
      781 gtacgaatct gacggtactt tgcggaaaga gcataattac aaggacggga agcaggtagg
      841 caaacagtat acttttctga aaggtacata tgatttgtat gagaccgttt atttcaatga
      901 agaaggtttg caggacggtg aatattcgtc cgtgtttacg tttggctcgc cacgtatact
      961 gggtagttat aagaatggaa agaagaatgg tcggtggact acttttgctg aaagcggaga
     1021 tacgctgatg attgaaacct atctggatgg aaaagaagat ggactccatg tctcatttgc
     1081 caacggaagt ggggtaaggc agaaagaata ttatatgaag aacgatcgta aagacggttt
     1141 ataccgtgaa tataatctgg aaaatggtga attgagatat gaagctacct atcaggccgg
     1201 cagattgcat ggcaaggaac gacggctgat agtgagcaac cgctttgatt attgggaaac
     1261 ttctacctat gtgaacggaa ggcagaacgg accgttcgaa gctcgttatg taaagaatga
     1321 ccagcttcgt gaatgtgggg aatataagaa tggtcgccgt gtaggacgat ggaaacgcta
     1381 cactattgat ggtaaactgg aaaaggaatg ggatgaaaac taaccggtag atgaaaggtc
     1441 agggcataaa aaaaggagca acgccttgct ccaacctttg ttaaccttaa atctaatact
     1501 atgaaaaaca cattgcaaag atacggactt ctgtgaaatc tgcaaattat ccaagtaaaa
     1561 cgctatgttt tataacattg attaagtgtt tgttttacgc tttatacttt tgttaatact
     1621 ttccgatggt ctgaaagagg actgctttcc ttctttttag aataataaat agctgaagtt
     1681 agagaacttt acagtattat ttcttatttt tgttcttaat tggattacag aaagaactac
     1741 gaaatgatga gatggatgaa gacgatgaga tatctgaagt ggatgctggt gctgttttgt
     1801 ttaatcggga tgacggcttg ccggcaggat acaccccgtt ttcgtattgg ggtggctcaa
     1861 tgcagcgatg attcatggcg acataagatg aatgatgaga ttcttcggga agcgatgttt
     1921 tataatggtg tttcggtgga aatccgttcg gcaggggatg ataacagtaa gcaggcggaa
     1981 gatgtccatt attttatgga cgaaggagtc gatctgctga ttatttccgc taacgaagct
     2041 gctcctatga ctccgattgt agaagaagct tatcagaaag gcatccccgt tattcttgta
     2101 gaccggaaga ttctttcgga taaatatact gcctatatcg gagccgataa ttatgaaatt
     2161 ggtcgttcgg taggaaacta tattgcctcc agtctgaaag ggaagggaaa tatagtagaa
     2221 ctgacaggat tgagcggttc gactcctgca atggaacggc atcagggatt tatggctgcc
     2281 atcagtaaat tcccggatat aaagctgatt gataaagcgg atgctgcttg ggaacgtggt
     2341 ccggcagaga tagaaatgga tagtatgctt cggaggcatc ctaagattga tgctgtgtat
     2401 gcccataatg accgtatcgc tccgggtgcc tatcaggcag caaagatggc agggcgggag
     2461 aaggaaatga tttttgtcgg catagatgcc ttgccgggta agggaaacgg actggaactg
     2521 gttctggaca gtgtgctgga tgccaccttt atctatccga ccaatggtga taaggtactg
     2581 caactggcta tggatattct ggagaagaaa ccctatccca aagaaacggt gatgaatacc
     2641 gctgttgtgg accgtaccaa cgcacacgtc atgcagttgc agaccacaca catttccgaa
     2701 ctcgacaaaa agattgaaac gctcaacgga cgtatcggtg gctatctctc tcaggtagct
     2761 acacaacagg tcgttttata cggcagtctg attatccttt tattggtagc cggcttatta
     2821 ttggtcgttt ataaatcact ccgctcaaag aatcgcttga ataaagaact ttttaagcag
     2881 aagcaacaat tggaagagca acgtgacaaa ctggaagaac agcgtgacca attgatacaa
     2941 ctttctcatc aactggaaga agctactcat gccaagctgg tattcttcac caatatttct
     3001 cacgacttcc gtactccgtt gacattggtt gccgatccgg tagaacattt gttggcggac
     3061 aagacactga gcggagatca gcaccggatg ctcatgctga ttcagcggaa tgtgaacatc
     3121 cttctgcgtc tggtcaatca gattctggat ttccgtaaat atgaaaacgg caagatggaa
     3181 tatactccgg ttacggtgga tgtcctttct tctttcgaag gatggaatga gtcttttcag
     3241 gcggcagccc gtaagaagca tatccatttt tcttttgata gtatgccgga tacggattat
     3301 catacactgg cagacatgga gaagctggaa cgtatttatt tcaatctcct gtccaatgcc
     3361 tttaagttta caccggaaaa cgggaaaata gccatccgtc tgtcttccct tagtaaagag
     3421 gacaagcgat ggatacgttt cacggtggca aataccggtt ccatgatttc tgccgaacat
     3481 atccgcaatg tattcgaccg tttctataag atcgatatgc accataccgg ttcgggaatc
     3541 ggactggcat tggtaaaagc cttcgtagaa atgcacggtg gtatgatctc tgtagagagc
     3601 gatgagaaac agggcacggt ctttaccgtt gaactgcctg tacagtcttg cgaggctgtt
     3661 gctgccgaac cggataccac ccttgtttct gcggattccc gtacaacaga tgttctattg
     3721 gcagaagagg aagaactgga aaaaggatat gactcttcca aaccgtccgt attgattatt
     3781 gatgataatg aggatatccg ttcgtatgtt catacgctgt tgcatacaga ctatacggtg
     3841 attgaagcgg cagacggctc cgaaggaatc cgtaaggcta tgaagtatgt tccggacctg
     3901 atcatttctg atgtgatgat gccgggcatt gatggcattg aatgttgccg ccggctgaaa
     3961 agtgagttac agacctgtca tattccggtt attctgctga cagcgtgttc actggacgaa
     4021 cagcgtattc agggatatga cggtggtgcg gattcttata tttcaaagcc gttcagttca
     4081 cagctgttgc tggcacgtgt ccgcaatctg atcgattctc accgtcgtct gaaacagttc
     4141 tttggtgacg ggcagacatt ggcaaaagaa gatgtctgcg atatggacaa ggattttgta
     4201 gaaagattca agtcattgat tgaagagaaa atgggagact ccggtttgaa tgtggaggac
     4261 ttgggcaaag acatgggact aagccgtgtg cagctttatc gcaagattaa atcattgact
     4321 aactactctc cgaatgaatt gctccgtatc gcccgtttga agaaggcagc ttctttgctt
     4381 gcttcttcgg acatgaccgt agcggagatt ggttatgaag tcggtttcag ttcaccttct
     4441 tatttcacca agtgctataa agagcagttc ggagagagcc cgacagactt cttgaaaagg
     4501 aaaggatgat ttcattgaga tcgtaaagag ggatatatga aagattataa agtagataaa
     4561 gagagttttt ccgaatcctt tcggaaggaa gtgtacgaag tcgtatccca gatacctgtg
     4621 ggaaaagtat ctacctatgg aggtattgct ttgctcttgg gggcacccca atgctcacgg
     4681 atggtggggc gtgcattgaa agaagtgccg gatgaattat ccattccttg ccatagagtt
     4741 gtaaattcca tcggaaggct ggtgcccggt tgggtggaac aaaaacaact cttgctggca
     4801 gaagaagttt ctttcaaagc taacggatgc gttaatctga aagaacattt gtggcacgtg
     4861 gatgaatgaa ggatgcaagg aaggtaagcc atatcatccg tatccataca ataaagaaaa
     4921 cccatacatg aagccataag gtcctggtaa tgaaatctct gatgggaaca gggacgaata
     4981 tgtcgatagg aacgatacat aacagcacaa aacagcacca aaatagaatc ttgtctgttg
     5041 cggtacgtgt tggtctgctc caataccaga gcatgaaacc tgccaatgcg ataatatagg
     5101 tatgtttctc ggcggagtca ctcagtaata ctacccagcc catgagaatg cccaaagctt
     5161 gggcacggaa ggcaaaagac gaccatttgc ggaaattccc caaaaagagc agagtcagca
     5221 gaccgagcat tcctatctga agtgcacgga aatgtggcaa tgtccatgct gcaatggggc
     5281 gggcatagaa aaatgaatca taagctccgg tggattgatg aacagcaaga ctatggcacc
     5341 attcttcata ataggggagc aaatctgcag gagctatttt gattaacggt aacgcaagca
     5401 atacaatgcc cattgcaacg gcatagccaa agttacgcca tacgtgagga tagcacagca
     5461 acaatgccag ttcgaaaatt ccatatactt tggtacatcc cgaaatcatg atgaacagaa
     5521 cagccagaaa tccacggtct ttttccaata acgtataggc gaataagaat aaataggcta
     5581 ccgttatgtt atactgaaat gaaagtaaac tttgtcctaa aatcagtaac agaaaaagga
     5641 acatacggca tttctgctgc tgggtgaatt gttggggcag cgtgaagatc gccacaaaga
     5701 acaatgaata attgaataga ttccatgcga aaggtcccag ccatgcaggc agatacgcaa
     5761 acggagcgaa caataccgtg aaaacaggag aataaaggaa gtagcgtccg tgagcttcta
     5821 caaattcggt tgtgtatggg ctgatgcctt gccagaagaa ttgagtagcg tctgagaaga
     5881 ccctaaagtt ttgatgccgt cctcgcataa attcgagcag agtcactata aaagcgagca
     5941 ggaaacctat catgtagaga ttctgccggc tatagaaaaa cggcattttg gggttctttt
     6001 tactaaggaa ctgtacttgg cttttgtcgt ctagtgtggc agtacctgtt tgtttttctt
     6061 ttgttgtgta atgacaatta tccttcccca ggaaaattgt aatagccctg ttgaacatat
     6121 aaatctagtt tagttattga tgccaaatat acggtgttta ggtgaaatat tcaaacttat
     6181 tttatattta tctgccggtt tgttctattt tgctgagtga taggggaata ttacccgaaa
     6241 actttccata tcattacaaa taaagccctc tgtatgcccc ggattttgaa tataatttgc
     6301 atgtttaatc tgttttttgt atctttgtgc cagcaagata ctggaacaga ctgtttttat
     6361 acataaaaat gctatttttt tgctattcgt tgaaaggatt atcttatcaa attctattcc
     6421 ttttttaatt actcagtctg tcaataatca ttttattaat tatttcggga ttcattgtta
     6481 tttgtcccgt atttaaatca gaactttata cgatataaag aaaaattcct gttatcgttt
     6541 gttcttgtct tgctgtatat attattttaa taacctaaac cattttattg tatgagtaaa
     6601 atagaaatta aagatctcta tctggttttt ggcaatgaga agcagaaggc tttgaagatg
     6661 ttgaaagaag gtaaaacaaa aagtgaaata ttaaaagcga ccggatgtac agttgcggtg
     6721 aaagatgcga atctttccat taatgaaggc gaaatattcg tcattatggg gctgtccggt
     6781 agtggaaagt ccactttact ccgctgcatc aaccgtttga tacgccctac ttccggagaa
     6841 gtgattatca atggaacaga catagccaaa gtatcggata aagaactgtt gcagattcgc
     6901 cgaaaagaac tggctatggt ctttcagaac ttcggtctgc ttcctcaccg ttctgtcttg
     6961 cataatatag ctttcggact cgaactacag ggagttaaaa agggagaacg ggagcagaaa
     7021 gcgatggaaa gtatgcaact ggtgggactg aaaggctacg agaatcagat ggtcagtgaa
     7081 ttgtcgggtg ggatgcagca gcgtgtcggg ctggcgcggg ctttggccaa taatcccgaa
     7141 gtcctgttga tggatgaggc tttctcggca ctcgatcctt tgatccgcgt acagatgcag
     7201 gatgaactgc tgactttgca gtcgaagatg aaaaaaacga ttgtctttat tactcacgac
     7261 ctgagtgaag cgattaaatt gggcgaccgg attgctatca tgaaggatgg agaaattgta
     7321 caaatcggta catcggaaga aatcctgacc gaacctgcca acgcttatgt agaacgattt
     7381 gtggagaatg tagatcgaag caagattatt acggcttcct cagttatggt agataaaccc
     7441 atagtggcac gtttgaagaa agaaggtccg gaggtgctga tccgtaagat gcgcgaacgg
     7501 aatctgaccg ttcttccggt agtcgattcc aataatctgt tagtaggaga ggtgcggttg
     7561 aacgacttgc tgaaactgcg aaaagagcaa atccgctcca tcgagtctgt agtaagacat
     7621 gaagttcatt cggtactggg ggatacggtg ctggaagata ttcttccgtt gatgacaaaa
     7681 acgaactcgc caatctgggt cgtaaatgag aatcgggagt ttgaaggcgt agtgccactt
     7741 tcctcattga tcatcgaagt aacgggaaaa gataaagaag aaattaatga aatcattcaa
     7801 aacgcaatag aattatgata aatatcggac aatatataga gacagccata aattggctca
     7861 cagaacattt tgcttccttt tttgatgctc tcagtatggg gattggagga ttcatagacg
     7921 gttttcagca cgtactgttt ggaatacctt tttatatcac aatcgcagtg ctggctgcac
     7981 tcgcctggtt taagtcgggt aaggggacag ccgtatttac cctcttaggt ttattactta
     8041 tttacggtat gggcttttgg gaagaaacga tgcagacact ggcattagta ctttcttcca
     8101 cctgtctggc attgcttttg ggcgttccgt tgggaatctg gactgccaac agtgatcgtt
     8161 gtaacaagat aatgcgccct gtcctcgatt ttatgcagac aatgcctgcc tttgtctatc
     8221 tgattcctgc tgtcctattc ttcggattgg gaactgtgcc gggagctttt gccaccatca
     8281 tctttgcaat gcctcctgtg gttcgtctga ccggcctggg cattcgtcag gttcctaaaa
     8341 acgtagtaga agcctcccgt tcttttggag ctactccctg gcagcttctt tataaggtgc
     8401 aattgccttt ggcgttgcct actattctga cgggaatcaa ccagacgatc atgatgtcac
     8461 tttcgatggt agtgattgct gccatgattt ctgcgggagg attgggagaa atcgtgctga
     8521 aaggtatcac ccaaatgaaa atcggactcg gatttgaagg cggtatcgca gtcgtgatat
     8581 tggcgatcgt gctggaccgc atcactcagg gtatggcaga taacagaaaa agtaaaaaga
     8641 aataagaatc acaccaaaga aaggaataat caatgaataa gataaaaatg attgcggcaa
     8701 tgtttattgc cggcatactt ttaaccttcg tttcctgcgg agacaacgga aagagtaaga
     8761 agataagtat cgcttatgcc aactggtcgg aagggattgc catgacaaac cttgccaaag
     8821 cgatttttga agatcaggga tacgatgtaa agttgctgaa tgccgacctt gcacctatat
     8881 ttacctctat ctcccgtaag aaagcagacg tatttatgga tgtctggatg cctgtcacta
     8941 tggaagatta tatgaaacaa tacggggata aactcgaagt tatcggggat atttatgatg
     9001 gtgcccgtat cgggctggtg gttccggatt acgttacgat caactcaatc gaagaactga
     9061 acgcggaaaa ggaacgtttc tccggtcaga ttgtcggtat tgatgccgga gccggtatta
     9121 tgaaagctac cgatcaggcc atcaaagact atggattgga ttataaactg atgacttcga
     9181 gcggacctgc catgactgct tccctaaaga aagcgattga taagaaagac tggattgtcg
     9241 tgacgggatg gacgcctcac tggatgttcg accgtttcaa gctgaaagtt cttcaggacc
     9301 cgaagctgat atatggaaat acggaatcca ttcataccat agcatggaaa ggttttagtg
     9361 agaaagaccc ttttgctgcc gaacttttgg gcaacattcg tctgactgat gcggaaatca
     9421 gctctttaat gactgctctg gaagaggcgc agacaatgga aagacaggct gcccgtcaat
     9481 ggatggaaga acatcaggaa ctggtaaaca gttggattcc tgagaaagat tgatatgcaa
     9541 acactacttt aaccatcctg ccattctttc tttaccatag aagtagtaga aaagtagtcc
     9601 cagccagctg gtaagaacga ttaatacaat cgctataagt cttttctcta cagccgcatt
     9661 tatattccaa atctctatgg cagctctgaa agtcagtatc aaaccgataa tccaaataac
     9721 aaatccgatc atatctttag agttttaatg aatatcttcg tgagaagtaa tcgttacttc
     9781 taagatataa acaaaaaagg caggaatctg tttccaggat tcctgccttt tattatgtac
     9841 aaagtatttc tacttattat tcagctgtat cagctcccca attttctctg gcaagacgtt
     9901 tgtagctgtt gtaacgccat ttagcgtttt cttcagcagc tttaaacagt tcttcagctt
     9961 cagcaggata ttgtttcatt acagaagcgt aacgaacttc acccttcaag aaaccttgga
    10021 agtcttccca gttaggttct ttgctatcca gttggaacgg attcttgcct tcttcttcca
    10081 aagcagggtt gtaacgccac aagtgccagt aaccgcactt aacagccttt tcttcttctt
    10141 cctggctctt acccatacca gctttcagac cgtggttgat acatggagcg taagcgatga
    10201 tcagtgatgg tcccggatat gcttcagctt cacggatagc tttcagagtc tgagcttggt
    10261 cagcacccat agcaatctga gcaacatata cataaccgta agtagtagcc atcagaccga
    10321 ggtctttctt acgtacacgc ttgcctgcag cagcaaactt agcgatagcg cctaccggag
    10381 tagctttaga agactgacca cctgtgttag agtaaacctc agtatccaat acaaggatgt
    10441 tgacgtcctt accggaagcg attacatggt caagaccacc gtaaccgata tcgtaagaag
    10501 cgccgtcacc accgatgatc cactggctgc gtttaacaag atattgttgc agatcagcga
    10561 tttgcttgca gtggttgcat ttatctttag cagcttctac catcggaatg atcttttcgg
    10621 ccagttcctt agtcttttct gcatccagca tattgttgat ccattcagca aatacttctt
    10681 tgtattcagc cgggcagcaa tcagaagcga tagcttcgtt cattactttc accagacggg
    10741 cacgcatctt ttcgttagcc agttccatac ccaaaccaaa ttcacagaag tcttcgaaca
    10801 aggagttagc ccatgcagga ccgtgaccct tttcgttcat agtgtacgga gtagaaggaa
    10861 ctgaaccgga gtagatagaa gaacatcctg tagcgttagc aaccatttca cggtcaccga
    10921 acaactgaga aatcagtttc acgtacggag tttcaccaca accggagcaa gcgcctgaga
    10981 actcaaacaa cggagttgcg aactgagagt tcttcacgtt agccttgatg tctaccaggt
    11041 gttgtttgct cttcacgttt tcagcgcagt aagtccagtt atcagcttcg gccaactggc
    11101 tttcaaggtg tttcatggtc aatgccttac cacccttctt cggattaccc ggacagatgt
    11161 cggcacagtt accgcaaccc agacaatcga gaacgtctac ctgaatacgg aatgtcatac
    11221 catcgaatgc tttacctaca gctttcagtt gctcgaactt agcacccttc tgctcttcag
    11281 catcgagtac gaacggacgg atagaagcgt gaggacaaac gtaagcacac ttgttacact
    11341 gaatacagtt ttcagcattc cattcgggaa cgaatgcagc tacaccacgt ttttcgtatt
    11401 tggaagtacc ttgataccaa gtaccgtctt cgataccctt gaatgcagat accggcagca
    11461 agtcaccgtc ctgtgcattg atcggacgaa ctacttcgtt gatgaaagca ggatcattgt
    11521 tttctgcttt tgcatcatcc ggcaggttag cccaagcagg atcgacagtc agagtcttgt
    11581 attcaccacc gcggtctaca gcagcgtagt tcttgttaac aacgtcttca cccttcttgc
    11641 cgtaagactt aacgatgaat ttcttcatct gttcaacagc ttgatctaca gggattacgc
    11701 ctgtgatacg gaagaatgca gactgaagga ttgtattggt acggttgccc aaaccaattt
    11761 ccattgcaat ctgagttgcg ttgatatagt atacagagat gttgttctgt gcaaagtatt
    11821 tcttcacctt gttaggcagg ttcttagcca gttcttcgcc ttcccagatg gtattcagca
    11881 agaaagaacc gttcttacgc aaaccacgtg ttacgtcgta catgtgcagg taagcctgaa
    11941 cgtgacaagc aacgaagttc ggagtattta ccaagtaagt agaacggatc ggagtatcac
    12001 cgaaacgcaa gtgagaacaa gtgaaaccac ccgacttctt ggagtcgtaa gagaagtaag
    12061 cctgacagtg tttgtcggtg ttgtcaccga taatcttaac agagttcttg ttggcaccta
    12121 cagtaccgtc agcacccaga ccgtagaatt tagcttcgaa cataccttca ccgcccagag
    12181 cgatttcttc tttctgagga agagaagtga acgtaacgtc gtctacgata ccgatagtga
    12241 agtggttctt cggcattggc atagccaagt tttcgaatac agagatgatc tgtgccggag
    12301 ttgtatcttt tgaacccaga ccgtagcgac cgccaacgat aacaggagca ttttctgcgc
    12361 catagaagca gtctttaacg tcaaggtaaa gaggttcgcc gttagcaccc ggttcttttg
    12421 tacggtcaag cactgcgatg ctctttgcag tcttgggtac agcagccagg aagtgtttag
    12481 cagagaacgg acgatacaag tgtacggcaa ccatacctac tttttcgccg tttgctacca
    12541 agtggtcgat agcttcgcgg gcagcttcag ttacagaacc cattgcgata attacgcgtt
    12601 ctgcatcttc tgcaccgtag taatcgaaca aaccgtattt gcggcctgtg atcttggaaa
    12661 tttcgttcat gtattcttct acgatagcag gaactgcttc atagtagtta ttgcatgatt
    12721 cacgatgttg gaagaagtgg tcggggtttt cagccatacc acgggcaacc ggcttcatcg
    12781 gattcagtgc acgggcacgg aattcagcca aagcttcctg gtcgatcagc ggagcgaggt
    12841 cgtcgttttc caacatttcg atcttctgga tttcgtgaga agtacggaaa ccatcgaaga
    12901 agttcatgaa cggaacgcgt gatttgatag tagccagatg agcaacacct gccaaatcca
    12961 taacttcctg tacagaacct tctgccaaca tagcgaagcc ggtttgacga gctgacatta
    13021 cgtcctgatg gtcaccgaag atacacaatg cgtgagaagc cagtgtacga gcagaaacgt
    13081 ggaatacaca aggcaagaat tcaccggcaa tcttgtacat gttagggatc atcaaaagaa
    13141 gaccctgaga agcagtgtaa gtagtagtca atgcaccagc ctgaagagaa ccgtgaactg
    13201 caccggcagc accaccttca gattgcattt cctgtaccaa tactgtttcg ccgaagatgt
    13261 tcttacgtcc tgcggcagcc cattcgtcta cgtactcagc catagtcgaa gaaggagtga
    13321 tggggtagat agctgctact tcagagaaca tatacgagat atgtgctgca gcttggttac
    13381 catcacatgt gatgaatttc ttctgtttag tcataactaa attaaatatt taagtaaata
    13441 aatcttttta gtataagaat ccgaacatcc aaagaggtat ttggttgccg cggcctatct
    13501 cagccttttg caacgcatac gtcacgtccg ggttattctt tatttttgta ccttccgcac
    13561 aaattttgaa cggcatcact tcgtctacca tgaaagagac gtttttatct cctttatgta
    13621 ccttatggtc tttccataaa gtgttaacga agaacgtgtc gagtacatcc tgttcttcca
    13681 ctttcaccgg ataaatggag tacatcaggt tagagttgtg catcataatc tttgacggtt
    13741 tctttgggaa ttcttctcct ttcgggtaaa ccagattaat cagacgcgcg tctgccagat
    13801 acttgatata gttcattacc gtagcgcggg atgtctgtac gtcacttgcc agttggctca
    13861 cgttcggagc tttcggtccg tccacagcca acaaatatag taattttttt atctttgaaa
    13921 gatatttcag ctcaatttgt ttgatcagca agatatccac ttctaccatc atgttcattg
    13981 ttttcagcag attctccgag aaattacgtt tttcaaggaa gaaagggtag aaaccatgat
    14041 gcaggtaatc ctgaaaataa tccagcggtc gtactttgga aagtactcct ttggctatct
    14101 gttcatgtgt actgaggatt tcttcgaggc tgtatgcccg gaatttcatt cctgtctgca
    14161 ggttcagaaa ttcacggaaa gagaatccgc gcaggttata acttttcgca atgtcacgca
    14221 attcgaggtt ttcctctttg agtcgcatga cggaagaacc ggtgaagaca atcttcaggc
    14281 tggggaaacg gtcatagcac attcgtagct ctttgctcca ttcgggatgt ttgaacacct
    14341 ggtcgatcag cagtactttt ccgccacgtt tctgaaactc gttggcgaag tcaacaaggc
    14401 tgtgaccgga gaaataaaag ttgttcatat tgatgaacag acaggaacgg tcggtgccga
    14461 atttctcttt ggcgtactgc aggaggaaag tggtttttcc tacgccacgt gtccctttga
    14521 taccaatcag acggtcactc cagtcgatct cgtccataag atcgcggcga acgggggcat
    14581 tggtgtgctc aacgaggtag gcgtgtgtgc gatagaatga ttccatttcg tttctttgtt
    14641 tttcggctgg caaatatagt gcttttttta ggatttgcaa agtagagata gcaaaaatgt
    14701 gctttaattt ataagtttct ctttattgtg taagttcctg attatttcct gtatatattt
    14761 gcagaataat gtgttgaatc catctttgac atgacgaaaa gacctgttta tatattcaat
    14821 ccggagcatg atatggcgtt ggcaagcggt gagacgaact atatggcgcc ggcttccgcc
    14881 cgacagatgg cgagtgacct ggcgttgctt cctatgtggt atgccgaagc gggaagtgcg
    14941 gtgcttgcac cgtctgctta taatgcggac ttcctgaaaa caaagagtga acttttgggc
    15001 atggatgtgg ccttgttgac ggaaccggaa gtggctgacg gtaaagaccg gaagttctct
    15061 ccgtgggggt gggaccctgc tttgcggaag cgtttgatga cattgggggc agatcagacg
    15121 gagctgcctt ctgcggatta tatgaatatt ctgagagagc attcgcatcg tctgcaggcg
    15181 gtaaagttgt tgcctgggtt gcggttgaat gaatacttct gtggagaatc tttttatttg
    15241 agtactttgg cggagtgcag tgcgttcgtc gaagggcggg aagcgtgctt gttaaaagct
    15301 ccgctttccg gaagcgggaa aggattgaat tggtgtaaag gcatatttac tacttttatt
    15361 tccggttggt gtgcccgtgt cgctgcttct cagggtgggg tggtaggcga acctatatat
    15421 aataaggtgg aagatttcgc tatggagttt tatgctgacg ggagaggaag ggttgttttt
    15481 gccggatatt cggtcttcca cacgggtggg agtgggatgt atgcagggaa tgacttgctg
    15541 tctgacgaga agattctgca gaaactatcg gcttatgtgc cacaagaaga atttatcagg
    15601 ctgcggactc gtttggaaga agaattgtca gctttgttcg gtggctttta tcatggatac
    15661 ttgggagtgg atatgatgat ttgtcatttt ccggatgaag cgcctgttta ccggattcat
    15721 ccttgtgtcg aaattaatct gcgaatgaat atgggggtgg tggcatggct cttgacggat
    15781 cgttatttgg ctgcggatgc ggaaggagtt tttcggattg attattatcc tttagccggt
    15841 caggctttgg aggaacatcg gcagatgtcg gcttcgttcc ctttgtccgt agagaataat
    15901 cgggtgtgtg ccggatattt gccgttagta ccggtgacgc ctcaaagccg gtatcgtgcg
    15961 tttcttttgc ttactctccc ccagtgaaaa agatagtgct tttgctctca tgctctaaca
    16021 gttcgtctgt atccctttat tcatcgatgt tttagctgtt agagatccag tggtag
//
