LOCUS       gnlProkkaFCMLPHOH_19   14022 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FCMLPHOH_19.
ACCESSION   gnlProkkaFCMLPHOH_19
VERSION     gnlProkkaFCMLPHOH_19
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 03:57:56
            Original ID  :: gnl|Prokka|FCMLPHOH_19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14022
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14022
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[4708:9022]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4709..9022
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14022
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14022
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             100..678
                     /locus_tag="ctg17_1"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQELHQWSDRRKLVTSVLLPMMVFVHADPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             689..1057
                     /locus_tag="ctg17_2"
                     /transl_table=11
                     /translation="MDAIILQENIEGLLSLVRMLLPDGGSAGCVYLDDLSALQRSIHEK
                     INDLYSQRGETPEQDATLCLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLL
                     KQQLSAVCYGMQELCEIN"
     CDS             1075..3486
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg17_3"
                     /sec_met_domain="Poly_export (E-value: 4.6e-18, bitscore:
                     57.3, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKENTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPTNYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIRSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAQPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3497..4645
                     /locus_tag="ctg17_4"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             4709..5428
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_5"
                     /sec_met_domain="NTP_transf_3 (E-value: 8.8e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             5449..6750
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_6"
                     /sec_met_domain="CTP_transf_like (E-value: 1.1e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.1e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             6767..7891
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_7"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5.9e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             7901..9022
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg17_8_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg17_8"
                     /sec_met_domain="Aminotran_5 (E-value: 8.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        7991..8998
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg17_8_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg17_8_Aminotran_5.1"
                     /locus_tag="ctg17_8"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9019..9162
                     /locus_tag="ctg17_9"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9401..10849
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg17_10"
                     /sec_met_domain="Polysacc_synt (E-value: 8.3e-31, bitscore:
                     99.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWSAIERFSLQGVQFIIQIILARLLLPSDYGMIGMLAIFLQVAQV
                     FIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIADFYNMPTLVLVI
                     RFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWMAYVGCGVWALVW
                     QTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLINTVYRNLYTIVIG
                     KKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCLTNAYRNYIRLSS
                     YIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQINLNLLWVKGRS
                     DLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYYTNSLIDLTLKLQ
                     VKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLSFLFKLDSFFCIL
                     TLIIKTKNIDENIKKDFSSNSKDN"
     CDS             10803..12062
                     /locus_tag="ctg17_11"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             12071..12820
                     /locus_tag="ctg17_12"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             12820..13860
                     /locus_tag="ctg17_13"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 tttcattttt gtttgcgtat tttcataaat atgtccatct ttgcgccatg aatcattccg
       61 ttacctaaga agtaacggat aaacatgggg taaaaaaata tgattttaag aaaaaagaaa
      121 tcactaaatg ctgggcctat taatgggaca ggggaaggcg tagcacactc aaaacgctgg
      181 tatgttgctt tggttcggat gcaccatgaa aagaaggttt ccgagcattt ggacaagatg
      241 ggaatcgaga atttcgttcc cgttcaacag gaacttcacc aatggagcga tcgtcgtaag
      301 ctggtcacct ccgtcttgct tcctatgatg gtgtttgtac acgccgatcc taaggaacgc
      361 atggaagtcc tgagtttttc tactgtcagc cgttacatgg tgatgcgcgg tgagagtagt
      421 cctgctgtaa ttcctgacga gcagatggct cgtttccgtt tcatgcttga ttattcggaa
      481 gaatcgataa gcatgaacag ttctcctttg gcccgtggcg aaaaggttcg cgtgattaaa
      541 ggtccgttga cgggtcttgt tggcgaactg gttaatgtgg atggtaaaag taagattgct
      601 gttcgcttga atatgctggg atgcgcctgt gttgatatgc ctgtcggtta tgtagagccg
      661 attatggcgg ctgtttaagg caagggatat ggatgctatt attttacaag aaaatataga
      721 gggtttatta agtttggtac gtatgctgct tcctgatggg gggagtgcag gctgcgtgta
      781 tttggatgat ctttcagcat tacaacgatc catccacgaa aagataaacg atttatattc
      841 tcaacggggg gagacaccgg aacaggatgc taccctgtgt ttggccatcc ttcagggata
      901 taatgtgtcg atgtacgcca atccggaaga cgaagaaaga aaacaggctg ttttgacccg
      961 ttctctgtct cttctcgatg ttcttccccc ttctcttctt aagcaacagt tatctgccgt
     1021 ctgttacggg atgcaggaac tgtgtgaaat caactgaaac ttttttattt gtcaatgaaa
     1081 atacaaagac tttttagcat tctactcttc tgtttgatgc tgggaagtgg ctcgcttatg
     1141 gctcagtcca tgagtgattc acaagtactg gaatatgtaa aggacggtat ccgccaaggc
     1201 aaggaacaga agcagcttgc ttccgaacta gcccgtaagg gggtaaccaa agaacaggca
     1261 atgcgtgtga agcagctata cgagcagcag aacaatgtaa acacctcgaa atcaacgggc
     1321 acggacatca acgaatcccg ccttcgtgaa gagactaagg agaatacttc tgatatgctg
     1381 gaggatcatc cgactactca ggaccttgcc cgtggcgatc aggtcttcgg gcgcaacatc
     1441 ttcaataccc gtaacctgac atttgaaccc agtgttaatc tggccactcc taccaattac
     1501 cgtcttggtc ccggtgatga agtcatcatt gatatctggg gtgcgagcca gaacacgatc
     1561 cgccagcaaa tctctcctga aggtactatc aacattcaga agatcggccc tgtcaacctt
     1621 agcggtatga cagtctctgc cgccaatgac tatctgaaga acgccctgaa taaaatatat
     1681 aacggtctga ataatactac cgatcctact tccgacatcc gtctgacgtt aggtaatatc
     1741 cgtactattc agattaatgt gatgggagaa gtcgtacagc ccggtaccta cgccctttct
     1801 tccttctcta ccgtcttcca tgcgctttat cgtgcaggcg gtgtgagtga tatcggtagc
     1861 ctccgaaacg ttcagttggt acgcaacgga aagaatattg ccaccatcga cgtctacgaa
     1921 ttcattatga aaggcaacac acaggatgac atccgcctac aggaaggtga cgttgtgatt
     1981 gttcctgcct atgatgtatt ggtaaagatt agcggcaagg taaaacgtcc tatgcgtttt
     2041 gaaatgaaga aagacgagaa ccttgctact ctcattaaat atgccggcgg ctttgaagct
     2101 gatgcctaca cccgttcatt acgtgttgtc cgtcagaatg gtgaggaata cgaagtcaac
     2161 acagtcaaag atatagatta caacatttat aaaatgcgta acggtgacgt agtaaccgcc
     2221 gaagccatcc ttaaccgctt cacaaacaaa ctggaaatcc gtggtgcagt ttaccgcccc
     2281 ggcatctacc agctcagcgg taaattgaat acgatccgcg aactggtcaa tgaagctcag
     2341 gggctgaccg gtgacgcttt tctgaatcgt gctgtcctct atcgccagcg tgaggacctg
     2401 accagtgaag ttgttcaaat agacatcagg tctatcatgg acggcacttc gccgaacctt
     2461 gccctaatga agaatgacat cctctacatc ccaagtatcc acgacctgga agatcgtggc
     2521 aatgtcacag ttcacggtga ggttgcccaa ccggattcct atccttatgc tgataacatg
     2581 acacttgagg atctgatcat ccaggccggt ggcttgaaag aagccgcctc tactgttcgc
     2641 attgatgtat caagacgaat caagaatcct cgtagtactg cggataatga tacgatcggt
     2701 cagatgtata ccttctcttt aaaggatggt tttgtcattg acggtcagcc cggttttatc
     2761 cttcagcctt atgatgaagt ttatgtccgt cgtagtcctg gctatcaggc acaacagaat
     2821 gtagccattg aaggtgaaat ccttttcgga ggaaattacg ccatgaccag ccgtgaggaa
     2881 cgtctttccg atttggtgaa taaagccggt ggtccgacca attatgccta tctgcgtggt
     2941 gcaaaactga cccgtgtggc taacgctagt gagaagaaac gtatgggtga tgtaattcgc
     3001 cttatgagca ggcaattggg cgaggccatg attgactctt tgggtattcg tgtcgaagat
     3061 acctttacgg ttggaattga tttggaaaaa gccttgagca atcctaaaag taatgccgat
     3121 cttgtcttac gtgaaggtga tgtgatctcc atacctaaga atactaatac tgtaactatc
     3181 aatggtgctg tcatggttcc gaatacggtt tcttatatga agggaaagaa tgtggattat
     3241 tacctgaatc aggccggtgg ctgttctgat aatgcaagga agagtaagaa gttcattgtt
     3301 tacatgaatg gtcaggtgac gaaggttaag ggtagtggta agaaacagat tgagccgggg
     3361 tgtgagatta ttgtgcctgg taaggctaag aagaaaggga acatagctaa tattttaggt
     3421 tatgctactt ccttcagttc tttgggaatg atgattgctt ctattgctaa tttgataaag
     3481 aaataaatga cctattatga ttgaaaagca atcttatcaa gaaccgtttt ctgaagtgga
     3541 taaaaggaaa gatgatgaaa tggaaataga cttgatggct attttttata agattattac
     3601 tgttcgtgga gtactatgca aagctgctgg agtgggagta ataattgcta tagtggtggc
     3661 attgagcatt cccaagcaat atacagtaaa ggttaccctt tctcctgaaa tgggtaatgc
     3721 gaagggaagt aatggtttag ccggacttgc tgcctcgttt ttgggagatg gggctctaat
     3781 aggggaaagc acagatgcct tgaacgcttc tctttcagca gatattgttt cttcaactcc
     3841 ttttttattg gaacttttag aaatggaagt ctccgtttct aaaaaggatg ataaaatgac
     3901 tttggggtct tatctcgatg aagagtcatc tccttggtgg gattatctta taggttttcc
     3961 gggcatagta ataggaggag ttaaatcatt attcggagaa gatacggttc ctgccagtgg
     4021 agggcggcaa ggaactatcg aattgacgaa agaagtaaat gagaagatta attttcttaa
     4081 aaagaagatt agtgcatcca ttgataagaa aaccgccata acgagcatta cggtcacctt
     4141 acaaaatccg cagatcactg cggttatagc agattctgtc gttcataaat tacaggaata
     4201 tattattggg tatcgaactt caaaagtaaa agaagactgt gcgtatttgg aacggttgtt
     4261 taaagaacgt cagcaggaat attatgctgc tcaaagaaaa tatgcggatt atgtagacgc
     4321 ccatgataat gtggttcttc aaagtgtacg tgctgagcag gagcgtttac agaacgacat
     4381 gagtttggct tatcagatat atagtcaggt tgctaatcag ttgcaggtat ccagagccaa
     4441 agtacaggag gaaaagccag tctttgcagt agttgagcct gccgttgtac ctttgaaacc
     4501 ttcaggtatg ggactcaaaa tttatatttt attatttgtg ttcctgtccg tatctggtac
     4561 tctcgtgtgg gtgttttttg gcaaaagtct gctggctagc ttgagaaaag aactgaaaaa
     4621 taaggagata gaacaggata aatgatgcta aaacgtcgtt tacaacattc ttacatcaat
     4681 taaattcact tactatatta ttaaacgaat gatacgtaca gctatgataa tggctgcggg
     4741 catgggaacc cgttttggcc aatatacaga attgatacct aaagggttcg tcaaagtggg
     4801 aggtattcca atgatagttc gttctattga tactttgtta tcatgtgaca ttgagcgaat
     4861 tgtaatcggt acaggatata aacaagaagt ttatgaagaa ttgaagacag actatcctat
     4921 gcttgaaacc tgttttagtc ctcgttatgc tgaaacaaat agtatgtata ctttatataa
     4981 tacgcgggag attctgggca atgatgattt tttattgtta gagtcagatt tgatttttga
     5041 gaaacaagca ataatgagct tattggagtg tcctgcggca gatgcaatgc taataactcc
     5101 agtgacaaag tttcaagatc agtattatgt ggaacatgat gataattttc gcctttcttc
     5161 atgttctgtc aataagaata aactaaacgc taaaggcgaa ttggtcggca tccataaact
     5221 atccggttcc ttttacaaaa taatgtgtgc tgattatgcg agtattgttg atgaacaacc
     5281 caatttggga tatgagtatg aattactacg aatatcttgt tctcaatctc ctgtttatgt
     5341 gcataaagta gaagggctga aatggtatga aatcgatgac atatcagatt tggaatatgc
     5401 agagaaatat attgttccgt attgttaatt aaaataatat atcaaattat gagtaagaca
     5461 gtttatattg ggatgactgc ggatattatg catccaggac ttatccgcat tattaatgag
     5521 gctactaaat acggtgatgt tataattggt cttcttacag ataaagctat tgcggagcat
     5581 aaacgccttc cttatctgac ctatgaacaa cgaaaagagg tagttcagaa tattaaaggc
     5641 gtatgtaaag ttgttcctca agaagaatgg agctatgttg agaatctcaa acgcattaaa
     5701 cctgactata taattcatgg tgacgactgg aaaaccgggc ctttacgtga agaacgtgtg
     5761 cgcgtatttg aagtgatgaa tgaacaggga ggaaaggtta tcgaaattcc atatactttg
     5821 ggaattaatt catcttcttt ggataaagat attaaggcta taggtacaac ccctgatgta
     5881 cgtttaaaat cacttcgtcg tttgataaat gccaaacccg tagttcgtat tttggaagct
     5941 catgatggac tatgtggctt gataattgaa aatcaggaaa tattaaaagg ggataagagg
     6001 gaagtatttg acggaatgtg gtctagtagc cttacggatt caaccagtaa aggtaaacct
     6061 gatattgagg cggttgattt aactacccga ttgcaagatt tgaataatat tctggagtgt
     6121 actactaaac ctattatttt tgatggagat acaggtggta aaattgaaca tttcgtattt
     6181 acagtacgca ctttagaacg tcatggaatt tcagctataa taattgaaga taaagttgga
     6241 ttaaaaaaga attcattgtt tggtacagat gttattcaaa ctcaagatac aatcgaaggt
     6301 ttctgtaata agatcaaagc aggaaaggca tctcagatta ctgatgattt tatgattatc
     6361 gctcgtattg agagccttat agcgggaaag ccggtaagtg atgctttaga gagagctttt
     6421 gcatatgtcc aagcgggagc ggacggtatt atgatacata gcaaaaataa gtcgggtgaa
     6481 gatataaaag aattttgttt ggcgtttcga aaacagtatg ctcatgtacc tatcgtggtt
     6541 gtgcctacta catatgatca tatttatgag tctgaattgt gtgattgggg tgtgaatata
     6601 attatttatg ctaatcatat gcttcgtgcc gcttatcctg ctatgatgaa tgtcgcaaag
     6661 ataatattag agaatgaacg tgctttagag gtgcgcgaac tgtgtatgcc cataaaagaa
     6721 atattggaac tgattccagg tactaaataa aaagaggaat atcattatgt taagcgtaga
     6781 aaaagtttat gaaacgtttc tgagtcatga cgttgatttt tttacaggag ttccagactc
     6841 attactaaaa aatatttgtg cctatatcac agaccatact tcacgtgaga aacatatcat
     6901 agctgctaat gaaggtgcgg ctgtaggaat tgcttcaggt tattatatgg catcaggtaa
     6961 ggttcctgtg gtttatatgc aaaattccgg cttgggtaat actgttaatc ctctgctgtc
     7021 tcttgcagat gaacaagtat acagttttcc aatgcttttg atgattggct ggcgtggtga
     7081 accgggaaca aaagatgaac ctcagcataa aaaacagggt gaggtaactt tagatttgtt
     7141 gaaagcaatg cggattcctt atataattct tgattcaaat gagaatgatg catttattca
     7201 gctccatgat atcatacaat cagcaaaaac taagaatatt cctcatgcaa taattattcg
     7261 gaaagatgtt tttggcaaat ataaacttca aaaagagttc ggatgtaatt atcctttatc
     7321 tcgtgaggat gctttgcaaa tagttgtgga ttatctgcct gaaaattcag tggtcgtttc
     7381 tactactggc aagctttctc gtgagttatt tgaatatcga gaaatgaaag agcaaggtca
     7441 tgaacatgat tttctcacgg taggctctat gggacatagt tcatcaatct ctttgggtat
     7501 tgctatagca aagcaagata gacctgttta ttgcttggat ggtgatggag catttattat
     7561 gcatttaggg gcaattagta acattggcga tttatctcct aaaaactatt atcatatttt
     7621 gtttaacaat ggtgctcacg agtctgtagg aggacagcct actttaggat ttagtttaga
     7681 tattccggct attgtccggg ggagcggata taagcatact tatactgttt gtacaaaagt
     7741 tgaaattgaa gaagcaatga agcagcttcc aaagttatgt ggtcctgttt tgttggaaat
     7801 aaaggttaaa atagattctc gggagaattt gggacgtccc acgactactc ctatagagaa
     7861 taaggagcat tttatggatt ttttaaaata aatatattcg atgaaaatag aaagaaaaat
     7921 attattaaat cctgggcctg ccactactac tgacagtgta aaaatggcac aagttgttcc
     7981 ggatatttgt cctcgcgaga aagaattcgc aggtatgatg aaacaacttc gggacgattt
     8041 ggtcagagtt gctcatggga atttggaaaa acataccgct gtattatttt gtggctcagg
     8101 aaccatcaat attgatatat gtctaaattc tcttcttcct gaagacaaaa gggtgcttat
     8161 agtgaataat ggggcatata gtacccgtgc tgtagaagtg tgtcaatatt atggtttgcc
     8221 tcatattaat ttggaatttt ccgtttacga acgtcctgat ttatcggtgg tggaaaatgt
     8281 gttgcaagaa aatcctgata tagctatggt ttatactact catcacgaga cgggtacagg
     8341 aattctgaac cctattcgcg agatgggcgc tatagctcat aaatatcagg ctaaatttgt
     8401 cgtcgatact acttcttctt tgggcatgat tccttttgat atagagaaag ataatgtgga
     8461 tttttgtatg gcatctgctc aaaaaggact tcaagcgatg acaggtcttt cttttattat
     8521 aggcaatgag gaacagatta agttttcaaa aaaatatccc aagcgttctt actattgtaa
     8581 tctttatttg cagtatgaga attttgagag aacaggtgaa atgcatttta ctccaccggt
     8641 acaaactatt tacgccactc gtcaggcatt aaatgaatat tttgaagtgg gtgaagaagc
     8701 taagtttgcc cgtcacaaaa gagtttttga ggctattcat tcaggtataa atgaaattgg
     8761 tcttaaaagt gtaataaagc gtgaatggca gtcaggactg gttgtctcag ttcaataccc
     8821 agaagatccc aactgggatt ttgagaaaat acatgattat tgttatgagc gtggatttac
     8881 gatttatcca ggtaagatat caactgagga tacttttaga atctgtgctt taggagagat
     8941 agaagtagat gatattgaga acttctttaa agtactaaaa gctgcattaa atcattataa
     9001 cgtcacatta ccgatgtcat gattgcagaa atattattga agattcgtca tttttatttt
     9061 tcccttcgtg gtatacactt ccatccggaa agtgttattt ctggagtgcc tattcgtagc
     9121 tttcgcttag taggcaaata tggcaatatt aatttgaggt gatgcattag gagttcttta
     9181 ttcttataaa aaggcatcgg tagttatagg agataatgtt tgtgtagggt aatttgcttt
     9241 tagtgggaga gaccatatta gaattgcggt aaggggcgaa gaagataata accaattagt
     9301 gagaatattg gaaaaatata attgatatcg gtaaatgtag ttgtttttat actgtattta
     9361 agtaatggaa aatctaaagc agaaaactgt atcaggaata atgtggagcg ctatagaacg
     9421 tttctcttta caaggagtac agtttataat tcaaataata ttagctcgtt tgttactacc
     9481 atcggattat ggtatgatcg ggatgttagc tatttttctt caagtcgctc aagtatttat
     9541 agatagcggt tttacaaatg ctttaatcca gaaaaaagat agaactgaag aggattttgc
     9601 cactgtcttt tattttaata ttcttgtcgc agtattattc tatggtatat tgtttttttc
     9661 ggcttctttg attgcagact tttataatat gccgacttta gttcttgtaa ttcgttttat
     9721 agcattgtcg ttgataataa atgctttatc ggctattcac agaacgaaat taattatttc
     9781 tgtaaacttt aaaactcaat ctaaaatttc attaggtgca gcttttatat caggcgtgat
     9841 tggaatatgg atggcttatg tcggttgcgg ggtttgggct ttagtttggc aaactctctt
     9901 aaatagtata attttgacaa ttttgtttta ctgtttagtt cattggaaac ctttacatac
     9961 tttctccaaa agttcttttg aaagattatt caatttcgga tctaaattat tgatctcaag
    10021 tcttatcaat acagtatatc gtaatctgta taccattgta ataggaaaaa agttttctgt
    10081 tgtagagctt ggttactata caagagcaga acaatttgct atttttcctt ccaataattt
    10141 aaatgcttta gtttctagag tagcgtatcc tattttaagt tccattcaag atgatgataa
    10201 atgtttaaca aacgcatatc gaaattatat cagattatcc tcatatataa tttttccttt
    10261 aatggtaggt ttacttgttt tggctaatcc tattattagt ctattgttaa cagataaatg
    10321 gtctggggtt gttattcttt tacagatatt atgtttggat tggatgtttg atcatttgag
    10381 ccaaattaat ttgaatttat tatgggttaa aggaagatct gatctgtcgt tacgtcttga
    10441 aataataaaa aagacgattg ctatattcat tctttttgtg tcaattccat ttgggcttga
    10501 ggtgatgtgt tggggtagag ttatttactc tctgatagcg acatatttga atacatatta
    10561 tactaattct cttattgatt tgaccttaaa gttgcaagtt aaagatgtat ttccaagttt
    10621 aatactctct ttcataatgg gggggatcgt ttttatatgt atttctttct ttgaaactga
    10681 tatagtaaaa attgtgattg gatgtattac tgggatgtcc ttctatattt tactttcttt
    10741 tctttttaag ctagattctt ttttttgtat tttaacattg atcattaaaa ctaaaaacat
    10801 agatgaaaat attaaaaaag atttttcaag taatagtaaa gataattaac cattgtgtgc
    10861 cagttgatag tagatcattg tattttattc ctcatcctaa ttgtagaaca gataaatatg
    10921 atattataaa ttattcgtca gataatgttc tcgttctgtt aaattatttg ctaaaaaaag
    10981 atagtgctga atattataaa atatatgttg aaatttatga ttcttctcgt atttcagaat
    11041 atcaagaata tatttatggc ataaatccta atattaggtg tactttttta tgtgcatgtg
    11101 ttggacgttt tttctttaat aaagtatctt ttaaggatat gttgtatgcc tttttttgtt
    11161 tttgtagagc aagtaaatgt tttacagcta ctttttatta tgatttttca tttaaaaaac
    11221 gctctcaaca gattatttgt ttggggtatt atactccatt caaagatgat tatcatatgg
    11281 gagatcattc ttatgataaa tttcgtaata caacatgtaa ctcatttgat tactctattg
    11341 ctacttcttg tttaagtgct agaataattt caatagattg tggaatctca tatgataaat
    11401 tcaaagtctt aggatttccc agaaatgatt tgttgatatc gaaaaataat tgcaatgtta
    11461 ttaaaagaga aatttcgaaa tttgcgggat atgatgtaac taaatatata gtttatactc
    11521 caacttttcg tgattatgag actgttactg aaggtaattt gcgttcaata ctcggatatg
    11581 ttgattgtga tttgttgaag ttatcgaaaa tactattgaa gtttaatgcg gctttaattc
    11641 ttaaattaca tcctttgcag aataaaacag tcttaaaaaa agatttaccc aaaggtatac
    11701 ttgtttttga acaaacatat aaatatggat tgtatgatct tttgtcattt tcagatggaa
    11761 tgattactga ttatacttct acctattttg attttttatt ggtaaataag ccagtcatat
    11821 ttaatttcta cgatattgaa gaatatcgta gagtaagagg tttctcattt gagccaatag
    11881 aatttttttg tgcaggtgat attgtttaca attataatga attgatagat gctgtgatgg
    11941 gacttctggc tgggaaagat attcatgctg aacatcgacg tcatatttct ttattgatga
    12001 atcaatttca agatgataat tcaacaaaga gaatatgtga catattttta aatgaaatat
    12061 aataaataaa atgaattatg catttgtggt gcaggcacgt ttaggttcta cacgtttgcc
    12121 tggaaaaata ttgaaacctt tctatggtaa tcaatcgatt cttgacttaa tggttcataa
    12181 gctttctgct atatcgaata ttccagtaat tattgctaca acaaattctg ttatcaatga
    12241 acctattgaa aagaaggcac ttgcattagg ggtaaagtgc ttcagaggtg aggagaatga
    12301 tgttttaaaa cgattcattg atgttgctga atattttgat atacagggta tattccgaat
    12361 atgttctgat aatccatttt tagatgtaca tgcggcaagg caattggtcg aaatagcaat
    12421 gaaatcttgt aacgattata taagttttga tattgatggt actccatcaa ttaaaactca
    12481 tttcggtttt tggggagaat ttgtaacgct tgatgcgctg aagcgagtta taggatttac
    12541 tgatgattta ttgtatcgtg aacatgttac taattatata tatagtcatc ctgaactttt
    12601 taatattcaa tggatttcag gatctccagt cgtgtcaaaa catcataata ttcgactcac
    12661 gattgatacg ttagaagatt tttctgtagc acagagaata tatagggatt tacaagaaaa
    12721 aagagtggaa atatcgatag aagtgattgt agactatgtt cgaagacatg cagaatacat
    12781 tcaactgatg aaacaacaaa taaaaaaaaa ttctaaataa tgaagaatac ttatattatt
    12841 ggtgaaatag ggcagaatca taatggttct gttgacttgg ctaagttgat tattgaatta
    12901 atctcacgac ctgtacatga ggatgttttt ggtatggatt tcatgccaat gaatgctgtt
    12961 aaaatgacta aaagagattt atcagaagaa ttggctgttt ctcaaatgaa tcaaatatat
    13021 gacaatccta attcttttgg gcgtacttat ggtgaacatc gtgcttttct tgagcttgat
    13081 gatcaagcgc attttgagat ttataaatat gctaagtcat taggattaga ttttatcgag
    13141 acgttatgtg ccaaaggatg tctgtctttg cttaaactgt tcacaccgga taggctaaaa
    13201 gttgctagtc gtgatttgac taacttacca ttgcttgaag cattagcaga aactcatatt
    13261 cctattatat tatcgacagg aatggctggt caaagagaac ttgacaatgc attagatgtg
    13321 ataacgagat atcatagtaa tatagctatt ctacattgtg tatctcagta tccaactcat
    13381 ccaaataatt tgaatctacg tacaataaca tatttgaaga agcattacaa taagtttgag
    13441 ataggttttt ctgatcatac aataggtatt tctgctgcta cagctgctgt agcgatggga
    13501 gcggaaatta tagaaaagca tgtaacaatt gatcggcata tgaaaggaac agaccagctt
    13561 ggctctttag gtccagatgg ggttaatcgt atgattcgag atattcgcat agcagagtgt
    13621 tggcttggta ctgaagatct ttatatagaa aaaggggtgg agaagtctaa gataaaactt
    13681 gaacgttcta ttgccactcg aaaatatatt ccagcaggta gtattattca agagtcggac
    13741 attcatttac tgagtcctgg tgatggttat aaatggatag ataaaaaaaa tgtaattggt
    13801 cattttgcta aacaagatat atcagcgaat gaaataatat atcctgattt tattgaatag
    13861 atatattcct actgcaactt gtattacggt atagagtact gcctgctata agctaagtag
    13921 tgattaataa ataagggtaa aatactaaaa aaatgaaaga gataaagctt atacttacag
    13981 atattgatgg cgtttggact gatggcggaa tgttttatga tc
//
