LOCUS       gnlProkkaLFAKPPKH_8    14281 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LFAKPPKH_8.
ACCESSION   gnlProkkaLFAKPPKH_8
VERSION     gnlProkkaLFAKPPKH_8
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 08:07:46
            Original ID  :: gnl|Prokka|LFAKPPKH_8
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 28390
            Orig. end    :: 42671
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14281
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9281]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9281
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..14281
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14281
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             359..937
                     /locus_tag="ctg6_20"
                     /transl_table=11
                     /translation="MILRKKKSLNAGPINGTGEGVAHSKRWYVALVRMHHEKKVSEHLD
                     KMGIENFVPVQQEFHQWSDRRKLVTSVLLPMMVFVHVDPKERMEVLSFSTVSRYMVMRG
                     ESSPAVIPDEQMARFRFMLDYSEESISMNSSPLARGEKVRVIKGPLTGLVGELVNVDGK
                     SKIAVRLNMLGCACVDMPVGYVEPIMAAV"
     CDS             948..1316
                     /locus_tag="ctg6_21"
                     /transl_table=11
                     /translation="MDAIILQENIEGLLSLVRMLLPGGGSAGCVYLDDLSALQRSIHEK
                     INDLYSQRGETPEQDATLCLAILQGYNVSMYANPEDEERKQAVLTRSLSLLDVLPPSLL
                     KQQLSAVCHGMQELCEIN"
     CDS             1334..3745
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 32.3;
                     E-value: 7e-10)"
                     /gene_kind="transport"
                     /locus_tag="ctg6_22"
                     /sec_met_domain="Poly_export (E-value: 1.3e-17, bitscore:
                     56.9, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIQRLFSILLFCLMLGSGSLMAQSMSDSQVLEYVKDGIRQGKEQ
                     KQLASELARKGVTKEQAMRVKQLYEQQNNVNTSKSTGTDINESRLREETKKNTSDMLED
                     HPTTQDLARGDQVFGRNIFNTRNLTFEPSVNLATPANYRLGPGDEVIIDIWGASQNTIR
                     QQISPEGTINIQKIGPVNLSGMTVSAANDYLKNALNKIYNGLNNTTDPTSDIRLTLGNI
                     RTIQINVMGEVVQPGTYALSSFSTVFHALYRAGGVSDIGSLRNVQLVRNGKNIATIDVY
                     EFIMKGNTQDDIRLQEGDVVIVPAYDVLVKISGKVKRPMRFEMKKDENLATLIKYAGGF
                     EADAYTRSLRVVRQNGEEYEVNTVKDIDYNIYKMRNGDVVTAEAILNRFTNKLEIRGAV
                     YRPGIYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIKSIMDGT
                     SPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGGLKEA
                     ASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPYDQVYVRRSPG
                     YQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKK
                     RMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIP
                     KNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKG
                     SGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             3756..4904
                     /locus_tag="ctg6_23"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             5001..5687
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_24"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-11, bitscore:
                     38.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLSCDIERIVIGTG
                     YKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLLESDLIFEKQAI
                     MSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKGELVGIHKLSGS
                     FYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEIDDISDLEYAEK
                     YIVPYC"
     CDS             5708..7009
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_25"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-12,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.4e-120, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.7e-62, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             7026..8150
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_26"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-19, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-19, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             8160..9281
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg6_27_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_27"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-30, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        8250..9257
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg6_27_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg6_27_Aminotran_5.1"
                     /locus_tag="ctg6_27"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             9278..9421
                     /locus_tag="ctg6_28"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             9624..11108
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_29"
                     /sec_met_domain="Polysacc_synt (E-value: 1.6e-30, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             11062..12321
                     /locus_tag="ctg6_30"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             12330..13079
                     /locus_tag="ctg6_31"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             13079..14119
                     /locus_tag="ctg6_32"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 cggagtaggt cagtgtatct gatttagaag cttgatatac agtgtttatc ggtgtgcgtt
       61 acttcttagg taacggaatg attcatggcg caaagatgga catatttatg aaaatacgca
      121 aacaaaaatg aaattaattt cggaaaatga atcaaatgca ggcataacag gcggaaaatg
      181 acaatatccg tgttatgtct tttttttatt ccaattcatg aaaaacacct tcacttctgc
      241 tttatttcct gaataccagt cctcttctga tgttttcgtt gaaaaaagtt cccttttctg
      301 cttgccctat gcttgttcgt tacctaagaa gtaacggata aacatggggt aaaaaaatat
      361 gattttaaga aaaaagaaat cactaaatgc tgggcctatt aatgggacag gggaaggcgt
      421 agcacactca aaacgctggt atgttgcttt ggttcggatg caccatgaaa agaaggtttc
      481 cgagcatctg gacaagatgg gtatcgagaa tttcgttccc gttcaacagg aattccacca
      541 atggagcgac cgtcgcaagc tggtcacctc cgtcttgctt cctatgatgg tcttcgtaca
      601 cgttgaccct aaggaacgca tggaagtcct gagtttttct actgtcagcc gttacatggt
      661 gatgcgcggc gagagtagtc ctgctgtaat tcctgacgag cagatggctc gtttccgttt
      721 catgcttgat tattcggaag aatcgataag catgaacagt tctcctttgg ctcgtggcga
      781 aaaggttcgc gtgatcaaag gtccgttgac gggtcttgtt ggcgaactgg tcaatgtgga
      841 tggtaaaagt aagattgctg ttcgcttgaa tatgctggga tgcgcctgtg ttgatatgcc
      901 tgtcggttat gtagagccga ttatggcggc tgtttaaggc aagggatatg gatgctatta
      961 ttttacaaga aaatatagag ggtttattaa gtttggtacg tatgctgctt cctggtgggg
     1021 ggagtgcagg ctgcgtgtat ttggatgatc tttcagcatt acaacgatcc atccacgaaa
     1081 agattaacga tttatattct caacgggggg agacaccgga gcaggatgct accctgtgtt
     1141 tggccatcct tcagggatat aatgtgtcga tgtacgccaa tccggaagac gaagaaagaa
     1201 aacaggctgt tttgacccgt tctctgtctc ttctcgatgt tcttccccct tctcttctta
     1261 agcaacagtt atctgccgtc tgtcatggga tgcaggaact gtgtgaaatc aactgaaact
     1321 tttttatttg tcaatgaaaa tacaacgact ttttagcatt ctactatttt gtttgatgct
     1381 gggaagtggc tcgcttatgg ctcagtccat gagtgactca caggtactgg aatatgtaaa
     1441 agacggcatc cgccaaggca aggaacagaa gcagcttgct tccgaactag cccgtaaggg
     1501 tgtaaccaaa gaacaggcaa tgcgtgtgaa gcagctatac gagcagcaga acaatgtaaa
     1561 tacctcgaaa tcaacgggca cggacatcaa cgaatcccgc ctgcgtgaag agactaagaa
     1621 gaatacttcc gatatgctgg aggatcatcc gactactcag gaccttgccc gtggtgatca
     1681 ggtcttcgga cgtaacatct tcaatacccg caacctgacg ttcgagccta gtgtcaacct
     1741 tgccactcct gccaattacc gtcttggtcc cggtgatgaa gtcatcattg atatctgggg
     1801 tgcgagccag aacacgatcc gccagcaaat ctctcctgaa ggtactatca acattcagaa
     1861 gatcggccct gtcaacctta gcggtatgac agtctctgcc gccaatgact atctgaagaa
     1921 cgccctgaat aaaatatata acggtctgaa taatactacc gatcctactt ccgacatccg
     1981 tctgacgtta ggtaatatcc gtactattca gattaatgtg atgggagaag tcgtacagcc
     2041 cggtacctac gccctttctt ccttctctac cgtcttccat gcgctttatc gtgcaggcgg
     2101 tgtgagtgat atcggtagcc tccgaaacgt tcagttggta cgcaacggaa agaatattgc
     2161 caccatcgac gtctacgaat tcattatgaa aggcaacaca caggatgaca tccgcctaca
     2221 ggaaggtgac gttgtgattg ttcctgccta tgatgtattg gtaaagatta gcggcaaggt
     2281 aaaacgtcct atgcgttttg aaatgaagaa agacgagaac cttgctactc tcattaaata
     2341 tgccggcggc tttgaagctg atgcctacac ccgttcatta cgtgttgtcc gtcagaatgg
     2401 tgaggaatac gaagtcaaca cagtcaaaga tatagattac aacatttata aaatgcgtaa
     2461 cggtgacgta gtaaccgccg aagccatcct taaccgcttc acaaacaaac tggaaatccg
     2521 tggcgctgtc tatcgtcccg gtatctacca gctcagcggt aaactgaaca cgatccgcga
     2581 acttgtccat gaagctcagg gtctgaccgg tgacgctttc ctgaatcgtg ccgtcctcta
     2641 tcgccagcgt gaagacctga ccagtgaagt tgttcagata gacattaagt ctatcatgga
     2701 cggcacttcc ccaaaccttg ccctaatgaa gaatgacatc ctctacattc caagtatcca
     2761 tgacctggaa gaccggggta atgtcacagt tcacggtgag gttgcccacc ctgattccta
     2821 tccttatgcg gataacatga cacttgagga tctgatcatt caggccggtg gcttgaaaga
     2881 agccgcctct actgtccgta ttgatatatc gagacgaatc aagaatcctc gtagtactgc
     2941 ggataatgat acgattggtc agatgtatac cttctcttta aaggatggtt ttgtaataga
     3001 tggtcagccc ggttttatcc ttgagcctta tgatcaggtt tatgtccgtc gcagtccggg
     3061 ctatcaggca caacagaatg tagccattga aggtgaaatc cttttcggag gaaattacgc
     3121 catgaccagc cgtgaggaac gtctttccga tttagtgaat aaagccggcg gtccgaccaa
     3181 ttatgcctat ctgcgtggtg cgaaactgac ccgtgtggct aacgctagtg aaaagaaacg
     3241 tatgggtgat gtaattcgcc ttatgagcag gcaattgggc gaagccatga ttgactcttt
     3301 gggtattcgt gttgaagata cttttacggt tggaatagat ttggaaaaag ccttgagcaa
     3361 tcctaaaagt aatgccgatc ttgtcttacg tgaaggtgat gtgatctcca tacctaagaa
     3421 tactaatact gtaactatca atggtgctgt catggttccg aatacggttt cttatatgaa
     3481 gggaaagaat gtggattatt acctgaatca ggccggtggc tgttctgata atgcaaggaa
     3541 gagtaagaag ttcattgttt acatgaatgg tcaggtgacg aaggttaagg gtagtggtaa
     3601 gaaacagatt gagccggggt gtgagattat tgtgcctggt aaggctaaga agaaagggaa
     3661 catagctaat attttaggtt atgctacttc cttcagttct ttgggaatga tgattgcttc
     3721 tattgctaat ttgataaaga aataaatgac ctattatgat tgaaaagcaa tcttatcaag
     3781 aaccgttttc tgaagtggat aaaaggaaag atgatgaaat ggaaatagac ttgatggcta
     3841 ttttttataa gattattact gttcgtggag tactatgcaa agctgctgga gtgggagtaa
     3901 taattgctat agtggtggca ttgagcattc ccaagcaata tacagtaaag gttacccttt
     3961 ctcctgaaat gggtaatgcg aagggaagta atggtttagc cggacttgct gcctcgtttt
     4021 tgggagatgg ggctctaata ggggaaagca cagatgcctt gaacgcttct ctttcagcag
     4081 atattgtttc ttcaactcct tttttattgg aacttttaga aatggaagtc tccgtttcta
     4141 aaaaggatga taaaatgact ttggggtctt atctcgatga agagtcatct ccttggtggg
     4201 attatcttat aggttttccg ggcatagtaa taggaggagt taaatcatta ttcggagaag
     4261 atacggttcc tgccagtgga gggcggcaag gaactatcga attgacgaaa gaagtaaatg
     4321 agaagattaa ttttcttaaa aagaagatta gtgcatccat tgataagaaa accgccataa
     4381 cgagcattac ggtcacctta caaaatccgc agatcactgc ggttatagca gattctgtcg
     4441 ttcataaatt acaggaatat attattgggt atcgaacttc aaaagtaaaa gaagactgtg
     4501 cgtatttgga acggttgttt aaagaacgtc agcaggaata ttatgctgct caaagaaaat
     4561 atgcggatta tgtagacgcc catgataatg tggttcttca aagtgtacgt gctgagcagg
     4621 agcgtttaca gaacgacatg agtttggctt atcagatata tagtcaggtt gctaatcagt
     4681 tgcaggtatc cagagccaaa gtacaggagg aaaagccagt ctttgcagta gttgagcctg
     4741 ccgttgtacc tttgaaacct tcaggtatgg gactcaaaat ttatatttta ttatttgtgt
     4801 tcctgtccgt atctggtact ctcgtgtggg tgttttttgg caaaagtctg ctggctagct
     4861 tgagaaaaga actgaaaaat aaggagatag aacaggataa atgatgctaa aacgtcgttt
     4921 acaacattct tacatcaatt aaattcactt actatattat taaacgaatg atacgtacag
     4981 ctatgataat ggctgcgggc atgggaaccc gttttggcca atatacagaa ttgataccta
     5041 aagggttcgt caaagtggga ggtattccaa tgatagttcg ttctattgat actttgttat
     5101 catgtgacat tgagcgaatt gtaatcggta caggatataa acaagaagtt tatgaagaat
     5161 tgaagacaga ctatcctatg cttgaaacct gttttagtcc tcgttatgct gaaacaaata
     5221 gtatgtatac tttatataat acgcgggaga ttctgggcaa tgatgatttt ttattgttag
     5281 agtcagattt gatttttgag aaacaagcaa taatgagctt attggagtgt cctgcggcag
     5341 atgcaatgct aataactcca gtgacaaagt ttcaagatca gtattatgtg gaacatgatg
     5401 ataattttcg cctttcttca tgttctgtca ataagaataa actaaacgct aaaggcgaat
     5461 tggtcggcat ccataaacta tccggttcct tttacaaaat aatgtgtgct gattatgcga
     5521 gtattgttga tgaacaaccc aatttgggat atgagtatga attactacga atatcttgtt
     5581 ctcaatctcc tgtttatgtg cataaagtag aagggctgaa atggtatgaa atcgatgaca
     5641 tatcagattt ggaatatgca gagaaatata ttgttccgta ttgttaatta aaataatata
     5701 tcaaattatg agtaagacag tttatattgg gatgactgcg gatattatgc atccaggact
     5761 tatccgcatt attaatgagg ctactaaata cggtgatgtt ataattggtc ttcttacaga
     5821 taaagctatt gcggagcata aacgccttcc ttatctgacc tatgaacaac gaaaagaggt
     5881 agttcagaat attaaaggcg tatgtaaagt tgttcctcaa gaagaatgga gctatgttga
     5941 gaatctcaaa cgcattaaac ctgactatat aattcatggt gacgactgga aaaccgggcc
     6001 tttacgtgaa gaacgtgtgc gcgtatttga agtgatgaat gaacagggag gaaaggttat
     6061 cgaaattcca tatactttgg gaattaattc atcttctttg gataaagata ttaaggctat
     6121 aggtacaacc cctgatgtac gtttaaaatc acttcgtcgt ttgataaatg ccaaacccgt
     6181 agttcgtatt ttggaagctc atgatggact atgtggcttg ataattgaaa atcaggaaat
     6241 attaaaaggg gataagaggg aagtatttga cggaatgtgg tctagtagcc ttacggattc
     6301 aaccagtaaa ggtaaacctg atattgaggc ggttgattta actacccgat tgcaagattt
     6361 gaataatatt ctggagtgta ctactaaacc tattattttt gatggagata caggtggtaa
     6421 aattgaacat ttcgtattta cagtacgcac tttagaacgt catggaattt cagctataat
     6481 aattgaagat aaagttggat taaaaaagaa ttcattgttt ggtacagatg ttattcaaac
     6541 tcaagataca atcgaaggtt tctgtaataa gatcaaagca ggaaaggcat ctcagattac
     6601 tgatgatttt atgattatcg ctcgtattga gagccttata gcgggaaagc cggtaagtga
     6661 tgctttagag agagcttttg catatgtcca agcgggagcg gacggtatta tgatacatag
     6721 caaaaataag tcgggtgaag atataaaaga attttgtttg gcgtttcgaa aacagtatgc
     6781 tcatgtacct atcgtggttg tgcctactac atatgatcat atttatgagt ctgaattgtg
     6841 tgattggggt gtgaatataa ttatttatgc taatcatatg cttcgtgccg cttatcctgc
     6901 tatgatgaat gtcgcaaaga taatattaga gaatgaacgt gctttagagg tgcgcgaact
     6961 gtgtatgccc ataaaagaaa tattggaact gattccaggt actaaataaa aagaggaata
     7021 tcattatgtt aagcgtagaa aaagtttatg aaacgtttct gagtcatgac gttgattttt
     7081 ttacaggagt tccagactca ttactaaaaa atatttgtgc ctatatcaca gaccatactt
     7141 cacgtgagaa acatatcata gctgctaatg aaggtgcggc tgtaggaatt gcttcaggtt
     7201 attatatggc atcaggtaag gttcctgtgg tttatatgca aaattccggc ttgggtaata
     7261 ctgttaatcc tctgctgtct cttgcagatg aacaagtata cagttttcca atgcttttga
     7321 tgattggctg gcgtggtgaa ccgggaacaa aagatgaacc tcagcataaa aaacagggtg
     7381 aggtaacttt agatttgttg aaagcaatgc ggattcctta tataattctt gattcaaatg
     7441 agaatgatgc atttattcag ctccatgata tcatacaatc agcaaaaact aagaatattc
     7501 ctcatgcaat aattattcgg aaagatgttt ttggcaaata taaacttcaa aaagagttcg
     7561 gatgtaatta tcctttatct cgtgaggatg ctttgcaaat agttgtggat tatctgcctg
     7621 aaaattcagt ggtcgtttct actactggca agctttctcg tgagttattt gaatatcgag
     7681 aaatgaaaga gcaaggtcat gaacatgatt ttctcacggt aggctctatg ggacatagtt
     7741 catcaatctc tttgggtatt gctatagcaa agcaagatag acctgtttat tgcttggatg
     7801 gtgatggagc atttattatg catttagggg caattagtaa cattggcgat ttatctccta
     7861 aaaactatta tcatattttg tttaacaatg gtgctcacga gtctgtagga ggacagccta
     7921 ctttaggatt tagtttagat attccggcta ttgtccgggg gagcggatat aagcatactt
     7981 atactgtttg tacaaaagtt gaaattgaag aagcaatgaa gcagcttcca aagttatgtg
     8041 gtcctgtttt gttggaaata aaggttaaaa tagattctcg ggagaatttg ggacgtccca
     8101 cgactactcc tatagagaat aaggagcatt ttatggattt tttaaaataa atatattcga
     8161 tgaaaataga aagaaaaata ttattaaatc ctgggcctgc cactactact gacagtgtaa
     8221 aaatggcaca agttgttccg gatatttgtc ctcgcgagaa agaattcgca ggtatgatga
     8281 aacaacttcg ggacgatttg gtcagagttg ctcatgggaa tttggaaaaa cataccgctg
     8341 tattattttg tggctcagga accatcaata ttgatatatg tctaaattct cttcttcctg
     8401 aagacaaaag ggtgcttata gtgaataatg gggcatatag tacccgtgct gtagaagtgt
     8461 gtcaatatta tggtttgcct catattaatt tggaattttc cgtttacgaa cgtcctgatt
     8521 tatcggtggt ggaaaatgtg ttgcaagaaa atcctgatat agctatggtt tatactactc
     8581 atcacgagac gggtacagga attctgaacc ctattcgcga gatgggcgct atagctcata
     8641 aatatcaggc taaatttgtc gtcgatacta cttcttcttt gggcatgatt ccttttgata
     8701 tagagaaaga taatgtggat ttttgtatgg catctgctca aaaaggactt caagcgatga
     8761 caggtctttc ttttattata ggcaatgagg aacagattaa gttttcaaaa aaatatccca
     8821 agcgttctta ctattgtaat ctttatttgc agtatgagaa ttttgagaga acaggtgaaa
     8881 tgcattttac tccaccggta caaactattt acgccactcg tcaggcatta aatgaatatt
     8941 ttgaagtggg tgaagaagct aagtttgccc gtcacaaaag agtttttgag gctattcatt
     9001 caggtataaa tgaaattggt cttaaaagtg taataaagcg tgaatggcag tcaggactgg
     9061 ttgtctcagt tcaataccca gaagatccca actgggattt tgagaaaata catgattatt
     9121 gttatgagcg tggatttacg atttatccag gtaagatatc aactgaggat acttttagaa
     9181 tctgtgcttt aggagagata gaagtagatg atattgagaa cttctttaaa gtactaaaag
     9241 ctgcattaaa tcattataac gtcacattac cgatgtcatg attgcagaaa tattattgaa
     9301 gattcgtcat ttttattttt cccttcgtgg tatacacttc catccggaaa gtgttatttc
     9361 tggagtgcct attcgtagct ttcgcttagt aggcaaatat ggcaatatta atttgaggtg
     9421 atgcattagg agttctttat tcttataaaa aggcatcggt agttatagga gataatgttt
     9481 gtgtagggta atttgctttt agtgggagag accatattag aattgcggta aggggcgaag
     9541 aagataataa ccaattagtg agaatattgg aaaaatataa ttgatatcgg taaatgtagt
     9601 tgtttttata ctgtatttaa gtaatggaaa atctaaagca gaaaactgta tcaggaataa
     9661 tgtggagcgc tatagaacgt ttctctttac aaggagtaca gtttataatt caaataatat
     9721 tagctcgttt gttactacca tcggattatg gtatgatcgg gatgttagct atttttcttc
     9781 aagtcgctca agtatttata gatagcggtt ttacaaatgc tttaatccag aaaaaagata
     9841 gaactgaaga ggattttgcc actgtctttt attttaatat tcttgtcgca gtattattct
     9901 atggtatatt gtttttttcg gcttctttga ttgcagactt ttataatatg ccgactttag
     9961 ttcttgtaat tcgttttata gcattgtcgt tgataataaa tgctttatcg gctattcaca
    10021 gaacgaaatt aattatttct gtaaacttta aaactcaatc taaaatttca ttaggtgcag
    10081 cttttatatc aggcgtgatt ggaatatgga tggcttatgt cggttgcggg gtttgggctt
    10141 tagtttggca aactctctta aatagtataa ttttgacaat tttgttttac tgtttagttc
    10201 attggaaacc tttacatact ttctccaaaa gttcttttga aagattattc aatttcggat
    10261 ctaaattatt gatctcaagt cttatcaata cagtatatcg taatctgtat accattgtaa
    10321 taggaaaaaa gttttctgtt gtagagcttg gttactatac aagagcagaa caatttgcta
    10381 tttttccttc caataattta aatgctttag tttctagagt agcgtatcct attttaagtt
    10441 ccattcaaga tgatgataaa tgtttaacaa acgcatatcg aaattatatc agattatcct
    10501 catatataat ttttccttta atggtaggtt tacttgtttt ggctaatcct attattagtc
    10561 tattgttaac agataaatgg tctggggttg ttattctttt acagatatta tgtttggatt
    10621 ggatgtttga tcatttgagc caaattaatt tgaatttatt atgggttaaa ggaagatctg
    10681 atctgtcgtt acgtcttgaa ataataaaaa agacgattgc tatattcatt ctttttgtgt
    10741 caattccatt tgggcttgag gtgatgtgtt ggggtagagt tatttactct ctgatagcga
    10801 catatttgaa tacatattat actaattctc ttattgattt gaccttaaag ttgcaagtta
    10861 aagatgtatt tccaagttta atactctctt tcataatggg ggggatcgtt tttatatgta
    10921 tttctttctt tgaaactgat atagtaaaaa ttgtgattgg atgtattact gggatgtcct
    10981 tctatatttt actttctttt ctttttaagc tagattcttt tttttgtatt ttaacattga
    11041 tcattaaaac taaaaacata gatgaaaata ttaaaaaaga tttttcaagt aatagtaaag
    11101 ataattaacc attgtgtgcc agttgatagt agatcattgt attttattcc tcatcctaat
    11161 tgtagaacag ataaatatga tattataaat tattcgtcag ataatgttct cgttctgtta
    11221 aattatttgc taaaaaaaga tagtgctgaa tattataaaa tatatgttga aatttatgat
    11281 tcttctcgta tttcagaata tcaagaatat atttatggca taaatcctaa tattaggtgt
    11341 acttttttat gtgcatgtgt tggacgtttt ttctttaata aagtatcttt taaggatatg
    11401 ttgtatgcct ttttttgttt ttgtagagca agtaaatgtt ttacagctac tttttattat
    11461 gatttttcat ttaaaaaacg ctctcaacag attatttgtt tggggtatta tactccattc
    11521 aaagatgatt atcatatggg agatcattct tatgataaat ttcgtaatac aacatgtaac
    11581 tcatttgatt actctattgc tacttcttgt ttaagtgcta gaataatttc aatagattgt
    11641 ggaatctcat atgataaatt caaagtctta ggatttccca gaaatgattt gttgatatcg
    11701 aaaaataatt gcaatgttat taaaagagaa atttcgaaat ttgcgggata tgatgtaact
    11761 aaatatatag tttatactcc aacttttcgt gattatgaga ctgttactga aggtaatttg
    11821 cgttcaatac tcggatatgt tgattgtgat ttgttgaagt tatcgaaaat actattgaag
    11881 tttaatgcgg ctttaattct taaattacat cctttgcaga ataaaacagt cttaaaaaaa
    11941 gatttaccca aaggtatact tgtttttgaa caaacatata aatatggatt gtatgatctt
    12001 ttgtcatttt cagatggaat gattactgat tatacttcta cctattttga ttttttattg
    12061 gtaaataagc cagtcatatt taatttctac gatattgaag aatatcgtag agtaagaggt
    12121 ttctcatttg agccaataga atttttttgt gcaggtgata ttgtttacaa ttataatgaa
    12181 ttgatagatg ctgtgatggg acttctggct gggaaagata ttcatgctga acatcgacgt
    12241 catatttctt tattgatgaa tcaatttcaa gatgataatt caacaaagag aatatgtgac
    12301 atatttttaa atgaaatata ataaataaaa tgaattatgc atttgtggtg caggcacgtt
    12361 taggttctac acgtttgcct ggaaaaatat tgaaaccttt ctatggtaat caatcgattc
    12421 ttgacttaat ggttcataag ctttctgcta tatcgaatat tccagtaatt attgctacaa
    12481 caaattctgt tatcaatgaa cctattgaaa agaaggcact tgcattaggg gtaaagtgct
    12541 tcagaggtga ggagaatgat gttttaaaac gattcattga tgttgctgaa tattttgata
    12601 tacagggtat attccgaata tgttctgata atccattttt agatgtacat gcggcaaggc
    12661 aattggtcga aatagcaatg aaatcttgta acgattatat aagttttgat attgatggta
    12721 ctccatcaat taaaactcat ttcggttttt ggggagaatt tgtaacgctt gatgcgctga
    12781 agcgagttat aggatttact gatgatttat tgtatcgtga acatgttact aattatatat
    12841 atagtcatcc tgaacttttt aatattcaat ggatttcagg atctccagtc gtgtcaaaac
    12901 atcataatat tcgactcacg attgatacgt tagaagattt ttctgtagca cagagaatat
    12961 atagggattt acaagaaaaa agagtggaaa tatcgataga agtgattgta gactatgttc
    13021 gaagacatgc agaatacatt caactgatga aacaacaaat aaaaaaaaat tctaaataat
    13081 gaagaatact tatattattg gtgaaatagg gcagaatcat aatggttctg ttgacttggc
    13141 taagttgatt attgaattaa tctcacgacc tgtacatgag gatgtttttg gtatggattt
    13201 catgccaatg aatgctgtta aaatgactaa aagagattta tcagaagaat tggctgtttc
    13261 tcaaatgaat caaatatatg acaatcctaa ttcttttggg cgtacttatg gtgaacatcg
    13321 tgcttttctt gagcttgatg atcaagcgca ttttgagatt tataaatatg ctaagtcatt
    13381 aggattagat tttatcgaga cgttatgtgc caaaggatgt ctgtctttgc ttaaactgtt
    13441 cacaccggat aggctaaaag ttgctagtcg tgatttgact aacttaccat tgcttgaagc
    13501 attagcagaa actcatattc ctattatatt atcgacagga atggctggtc aaagagaact
    13561 tgacaatgca ttagatgtga taacgagata tcatagtaat atagctattc tacattgtgt
    13621 atctcagtat ccaactcatc caaataattt gaatctacgt acaataacat atttgaagaa
    13681 gcattacaat aagtttgaga taggtttttc tgatcataca ataggtattt ctgctgctac
    13741 agctgctgta gcgatgggag cggaaattat agaaaagcat gtaacaattg atcggcatat
    13801 gaaaggaaca gaccagcttg gctctttagg tccagatggg gttaatcgta tgattcgaga
    13861 tattcgcata gcagagtgtt ggcttggtac tgaagatctt tatatagaaa aaggggtgga
    13921 gaagtctaag ataaaacttg aacgttctat tgccactcga aaatatattc cagcaggtag
    13981 tattattcaa gagtcggaca ttcatttact gagtcctggt gatggttata aatggataga
    14041 taaaaaaaat gtaattggtc attttgctaa acaagatata tcagcgaatg aaataatata
    14101 tcctgatttt attgaataga tatattccta ctgcaacttg tattacggta tagagtactg
    14161 cctgctataa gctaagtagt gattaataaa taagggtaaa atactaaaaa aatgaaagag
    14221 ataaagctta tacttacaga tattgatggc gtttggactg atggcggaat gttttatgat
    14281 c
//
