LOCUS       c00133_gnlPro..        16673 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PDDFDHOE_136.
ACCESSION   c00133_gnlPro..
VERSION     c00133_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 10:02:41
            Original ID  :: gnl|Prokka|PDDFDHOE_136
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16673
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16673
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3115:6673](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3116..6673
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16673
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16673
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(543..1130)
                     /locus_tag="ctg133_1"
                     /transl_table=11
                     /translation="VVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVFHTGGSGMYAGND
                     LLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDMMICHFPDEAPVY
                     RIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALEEHRQMSASFPLS
                     VENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1362..1826
                     /locus_tag="ctg133_2"
                     /transl_table=11
                     /translation="MRMLSQNIHIIRRRQLRLICPQCHQTLPQSRVPPPRRELPVFTVS
                     HFRFRQQGHIHAQKFTLCFQEVRIISRRCKHRTSRFGIPHRKQRQVTRHLSGGSRRHIV
                     RLTACQRHIMLRIEYINRSFRHVKDGFNTLFCKYIQEIIRNLHNKEKLIN"
     CDS             complement(1910..2203)
                     /locus_tag="ctg133_3"
                     /transl_table=11
                     /translation="MFEHLVDQQYFSATFLKLVGEVNKAVTGEIKVVHIDEQTGTVGAE
                     FLFGVLQEESGFSYATCPFDTNQTVTPVDLVHKIAANGGIGVLNEVGVCAIE"
     CDS             complement(2222..2425)
                     /locus_tag="ctg133_4"
                     /transl_table=11
                     /translation="MCTEDFFEAVCPEFHSCLQVQKFTERESAQVITFRNVTQFEVFLF
                     ESHDGRTGEDNLQAGETVIAHS"
     CDS             2552..3082
                     /locus_tag="ctg133_5"
                     /transl_table=11
                     /translation="MNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLAS
                     DVQTSRATVMNYIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQD
                     VLDTFFVNTLWKDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGR
                     GNQIPLWMFGFLY"
     CDS             3116..6673
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg133_6"
                     /sec_met_domain="PFOR_II (E-value: 1.2e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.7e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.9e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.5e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 6e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.1e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.1e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.9e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             complement(6997..7857)
                     /locus_tag="ctg133_7"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7885..8715)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg133_8"
                     /sec_met_domain="BPD_transp_1 (E-value: 7e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8712..9938)
                     /locus_tag="ctg133_9"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             complement(10495..10719)
                     /locus_tag="ctg133_10"
                     /transl_table=11
                     /translation="VSFYKFSCVWADALPEELSSVREDHKVLMPSSYKFEQSHYKSEQE
                     TYHVEIPPAIEKRHFGVLFTKELYLAFVV"
     CDS             10885..11697
                     /locus_tag="ctg133_11"
                     /transl_table=11
                     /translation="MFLFLLLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLI
                     MISGCTKVYGIFELALLLCYPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCH
                     SLAVHQSAGAYDSFFYARPIAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQA
                     LGILMGWVVLLSDSAEKHTYIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDI
                     FVPVPIRDFITRTLWLHVWVFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11660..11992)
                     /locus_tag="ctg133_12"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12020..14677)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.1e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg133_13"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.8e-20, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VAQCSDDSWRHKMNDEILREAMFYNGVSVEIRSAGDDNSKQAEDV
                     HYFMDEGVDLLIISANEAAPMTPIVEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIG
                     RSVGNYIASSLKGKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAAWERG
                     PAEIEMDSMLRRHPKIDAVYAHNDRIAPGAYQAAKMAGREKEMIFVGIDALPGKGNGLE
                     LVLDSVLDATFIYPTNGDKVLQLAMDILEKKPYPKETVMNTAVVDRTNAHVMQLQTTHI
                     SELDKKIETLNGRIGGYLSQVATQQVVLYGSLIILLLVAGLLLVVYKSLRSKNRLNKEL
                     FKQKQQLEEQRDKLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEH
                     LLADKTLSGDQHRMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVTVDVLSSFEGW
                     NESFQAAARKKHIHFSFDSMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGKIAVRL
                     SSLSKEDKRWIRFTVANTGSMISAEHIRNVFDRFYKIDMHHTGSGIGLALVKAFVEMHG
                     GMISVESDEKQGTVFTVELPVQSCEAVAAKPDTTLVSADSRTTDVLLAEEEELEKGYDS
                     SKPSVLIIDDNEDIRSYVHTLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGID
                     GIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNL
                     IDSHRRLKQFFGDGQTLAKEDVCDMDKDFVERFKSLIEEKMGDSGLNVEDLGKDMGLSR
                     VQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFAKCYKE
                     QFGESPTDFLKRKG"
     CDS             complement(14658..14777)
                     /locus_tag="ctg133_14"
                     /transl_table=11
                     /translation="MDEDDEISEVDAGAVWFNRDDGLPAGYTPFSYWGGSMQR"
     CDS             complement(15106..16332)
                     /locus_tag="ctg133_15"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 gagtaaacta attcagttat aacaaacgaa gttgtcaact aaaaccagta cacatcattc
       61 cattgcttga aaccagagtt tcatcggtgt gaaactgtag tttcatcggt gagaaactag
      121 agtttcatac gcttgaaact ttagttccaa acgctcgaaa ctatctgaaa ctactgttga
      181 tttgattgac ttaaccgcat gttccaatca cattgaacgc atcagctact tcaatagtac
      241 tgctctctct gaaaacatta aatcatatat cagtcaataa tacataaatt atcagtcttt
      301 aatacctgat ttctcaatta ttaatatctg agaaatcaaa cgttaacagt tgagatatca
      361 gatattaaca tcctgtaaat caaagaataa cacagtaaaa acggtattta tcaggacgat
      421 gcagagtgag agcaagtcct tgctctcact ctgctaccac tggatctcta acagctaaaa
      481 catcgatgaa taaagggata cagacgaact gttagagcat gagagcaaaa gcactatctt
      541 tttcactggg ggagagtaag caaaagaaac gcacgatacc ggctttgagg cgtcaccggt
      601 actaacggca aatatccggc acacacccga ttattctcta cggacaaagg gaacgaagcc
      661 gacatctgcc gatgttcctc caaagcctga ccggctaaag gataataatc aatccgaaaa
      721 actccttccg catccgcagc caaataacga tccgtcaaga gccatgccac cacccccata
      781 ttcattcgca gattaatttc gacacaagga tgaatccggt aaacaggcgc ttcatccgga
      841 aaatgacaaa tcatcatatc cactcccaag tatccatgat aaaagccacc gaacaaagct
      901 gacaattctt cttccaaacg agtccgcagc ctgataaatt cttcttgtgg cacataagcc
      961 gatagtttct gcagaatctt ctcgtcagac agcaagtcat tccctgcata catcccactc
     1021 ccacccgtgt ggaagaccga atatccggca aaaacaaccc ttcctctccc gtcagcataa
     1081 aactccatag cgaaatcttc caccttatta tatataggtt cgcctaccac cccaccctga
     1141 gaagcagcga cacgggcaca ccaaccggaa ataaaagtag taaatatgcc tttacaccaa
     1201 ttcaatcctt tcccgcttcc ggaaagcgga gcttttaaca agcacgcttc ccgcccttcg
     1261 acgaacgcac tgcactccgc caaagtactc aaataaaaag attctccaca gaagtattca
     1321 ttcaaccgca acccaggcaa caactttacc gcctgcagac gatgcgaatg ctctctcaga
     1381 atattcatat aatccgcaga aggcagctcc gtctgatctg cccccaatgt catcaaacgc
     1441 ttccgcaaag cagggtccca cccccacgga gagaacttcc ggtctttacc gtcagccact
     1501 tccggttccg tcaacaaggc cacatccatg cccaaaagtt cactctttgt tttcaggaag
     1561 tccgcattat aagcagacgg tgcaagcacc gcacttcccg cttcggcata ccacatagga
     1621 agcaacgcca ggtcactcgc catctgtcgg gcggaagccg gcgccatata gttcgtctca
     1681 ccgcttgcca acgccatatc atgctccgga ttgaatatat aaacaggtct tttcgtcatg
     1741 tcaaagatgg attcaacaca ttattctgca aatatataca ggaaataatc aggaacttac
     1801 acaataaaga gaaacttata aattaaagca catttttgct atctctactt tgcaaatcct
     1861 aaaaaaagca ctatatttgc cagccgaaaa acaaagaaac gaaatggaat cattctatcg
     1921 cacacacgcc tacctcgttg agcacaccaa tgcccccgtt cgccgcgatc ttatggacga
     1981 gatcgactgg agtgaccgtc tgattggtat caaagggaca cgtggcgtag gaaaaaccac
     2041 tttcctcctg cagtacgcca aagagaaatt cggcaccgac cgttcctgtc tgttcatcaa
     2101 tatgaacaac ttttatttct ccggtcacag ccttgttgac ttcgccaacg agtttcagaa
     2161 acgtggcgga aaagtactgc tgatcgacca ggtgttcaaa catcccgaat ggagcaaaga
     2221 gctacgaatg tgctatgacc gtttccccag cctgaagatt gtcttcaccg gttcttccgt
     2281 catgcgactc aaagaggaaa acctcgaatt gcgtgacatt gcgaaaagtt ataacctgcg
     2341 cggattctct ttccgtgaat ttctgaacct gcagacagga atgaaattcc gggcatacag
     2401 cctcgaagaa atcctcagta cacatgaaca gatagccaaa ggagtacttt ccaaagtacg
     2461 accgctggat tattttcagg attacctgca tcatggtttc taccctttct tccttgaaaa
     2521 acgtaatttc tcggagaatc tgctgaaaac aatgaacatg atggtagaag tggatatctt
     2581 gctgatcaaa caaattgagc tgaaatatct ttcaaagata aaaaaattac tatatttgtt
     2641 ggccgtggac ggaccgaaag ctccgaacgt gagccaactg gcaagtgacg tacagacatc
     2701 ccgcgctacg gtaatgaact atatcaagta tctggcagac gcgcgtctga ttaatctggt
     2761 ttacccgaaa ggagaagaat tcccaaagaa accgtcaaag attatgatgc acaactctaa
     2821 cctgatgtac tccatttatc cggtgaaagt ggaagaacag gatgtactcg acacgttctt
     2881 cgttaacact ttatggaaag accataaggt acataaagga gataaaaacg tctctttcat
     2941 ggtagacgaa gtgatgccgt tcaaaatttg tgcggaaggt acaaaaataa agaataaccc
     3001 ggacgtgacg tatgcgttgc aaaaggctga gataggccgc ggcaaccaaa tacctctttg
     3061 gatgttcgga ttcttatact aaaaagattt atttacttaa atatttaatt tagttatgac
     3121 taaacagaag aaattcatca catgtgatgg taaccaagct gcagcacata tctcgtatat
     3181 gttctctgaa gtagcagcta tctaccccat cactccttct tcgactatgg ctgagtacgt
     3241 agacgaatgg gctgccgcag gacgtaagaa catcttcggc gaaacagtat tggtacagga
     3301 aatgcaatct gaaggtggtg ctgccggtgc agttcacggt tctcttcagg ctggtgcatt
     3361 gactactact tacactgctt ctcagggtct tcttttgatg atccctaaca tgtacaagat
     3421 tgccggtgaa ttcttgcctt gtgtattcca cgtttctgct cgtacactgg cttctcacgc
     3481 attgtgtatc ttcggtgacc atcaggacgt aatgtcagct cgtcaaaccg gcttcgctat
     3541 gttggcagaa ggttctgtac aggaagttat ggatttggca ggtgttgctc atctggctac
     3601 tatcaaatca cgcgttccgt tcatgaactt cttcgatggt ttccgtactt ctcacgaaat
     3661 ccagaagatc gaaatgttgg aaaacgacga cctcgctccg ctgatcgacc aggaagcttt
     3721 ggctgaattc cgtgcccgtg cactgaatcc gatgaagccg gttgcccgtg gtatggctga
     3781 aaaccccgac cacttcttcc aacatcgtga atcatgcaat aactactatg aagcagttcc
     3841 tgctatcgta gaagaataca tgaacgaaat ttccaagatc acaggccgca aatacggttt
     3901 gttcgattac tacggtgcag aagatgcaga acgcgtaatt atcgcaatgg gttctgtaac
     3961 tgaagctgcc cgcgaagcta tcgaccactt ggtagcaaac ggcgaaaaag taggtatggt
     4021 tgccgtacac ttgtatcgtc cgttctctgc taaacacttc ctggctgctg tacccaagac
     4081 tgcaaagagc atcgcagtgc ttgaccgtac aaaagaaccg ggtgctaacg gcgaacctct
     4141 ttaccttgac gttaaagact gcttctatgg cgcagaaaat gctcctgtta tcgttggcgg
     4201 tcgctacggt ctgggttcta aagatacaac tccggcacag atcatctctg tattcgagaa
     4261 cttggctatg ccaatgccga agaaccactt cactatcggt atcgtagacg acgttacgtt
     4321 cacttctctt cctcagaaag aagaaatcgc tctgggcggt gaaggtatgt tcgaagctaa
     4381 attctacggt ctgggtgctg acggtacggt aggtgccaac aagaactctg ttaagattat
     4441 cggtgacaac accgacaaac actgtcaggc ttacttctct tacgactcca agaagtcggg
     4501 tggtttcact tgttctcacc tgcgtttcgg tgatactccg atccgttcta cttacttggt
     4561 aaatactccg aacttcgttg cttgtcacgt tcaggcttac ctgcacatgt acgacgtaac
     4621 acgtggtttg cgtaagaacg gttctttctt gctgaacacc atctgggaag gcgaagaact
     4681 ggctaagaac ctgcctaaca aggtgaagaa atactttgca cagaacaaca tctctgtata
     4741 ctatatcaac gcaactcaga ttgcaatgga aattggtctg ggcaaccgta ccaatacaat
     4801 ccttcagtct gcattcttcc gtatcacagg cgtaattcct gtagatcaag ctgttgaaca
     4861 gatgaagaaa ttcatcgtta agtcttacgg caagaagggt gaagacgttg ttaacaaaaa
     4921 ctacgctgct gtagaccgcg gtggtgaata caagactctg actgtcgatc ctgcttgggc
     4981 taacttgccg gatgatgcaa aagcagaaaa caatgatcct gctttcatca acgaagtagt
     5041 tcgtccgatc aatgcacagg acggtgactt gctgccggta tctgcattca agggtatcga
     5101 agacggtact tggtatcaag gtacttccaa atacgaaaaa cgtggtgtag ctgcattcgt
     5161 tcccgaatgg aatgctgaaa actgtattca gtgtaacaag tgtgcttacg tttgtcctca
     5221 cgcttctatc cgtccgttcg tactcgatgc tgaagagcag aagggtgcta agttcgagca
     5281 actgaaagct gtaggtaaag tattcgacgg tatgacattc cgtattcagg tagacgttct
     5341 cgactgtctg ggttgcggta actgtgccga catctgtccg ggtaatccga agaagggtgg
     5401 caaggcattg accatgaaac accttgaaag ccagttggcc gaagctgata actggactta
     5461 ctgcgcagaa aacgtgaaga gcaaacaaca cctggtagac atcaaggcta acgtgaagaa
     5521 ctctcagttc gcaactccgt tgtttgagtt ctcaggcgct tgctccggtt gtggtgaaac
     5581 tccgtacgtg aaattgattt ctcagttgtt cggtgaccgt gaaatggttg ctaacgctac
     5641 aggatgttct tctatctact caggttcagt tccttctact ccgtacacta tgaacgaaaa
     5701 gggtcacggt cctgcatggg ctaactcctt gttcgaagac ttctgtgaat ttggtctggg
     5761 tatggaactg gctaacgaaa agatgcgtgc ccgtctggtg aaagtgatga acgaagctat
     5821 cgcttctgat tgctgcccgg ctgaatacaa agaagtattt gctgaatgga tcaacaatat
     5881 gctggatgca gaaaagacta aggaactggc cgaaaagatc attccgatgg tagaagctgc
     5941 taaagataaa tgcaaccact gcaagcaaat cgctgatctg caacaatatc ttgttaaacg
     6001 cagccaatgg atcatcggtg gtgacggtgc ttcttatgat atcggttacg gtggtcttga
     6061 ccatgtaatc gcttccggta aggacgttaa catccttgta ttggatactg aggtttactc
     6121 taacacaggt ggtcagtctt ctaaagctac tccggtaggc gctatcgcta agtttgctgc
     6181 tgcaggtaag cgtgtacgta agaaagacct cggtctgatg gctactactt acggttatgt
     6241 atatgttgct cagattgcta tgggtgctga ccaggctcag actctgaaag ctatccgtga
     6301 agctgaagca tatccgggac catcactgat catcgcttac gctccatgta tcaaccacgg
     6361 tctgaaagcc ggtatgggta agagccagga agaagaagaa aaggctgtta agtgcggtta
     6421 ctggcacttg tggcgttaca accctgcttt ggaagaagaa ggcaagaatc cgttccaact
     6481 ggatagcaaa gaacctaact gggaagactt ccaaggtttc ttgaagggtg aagttcgtta
     6541 cgcttctgta atgaaacaat atcctgctga agctgaagaa ctgtttaaag ctgctgaaga
     6601 aaacgctaaa tggcgttaca acagctacaa acgtcttgcc agagaaaact ggggagctga
     6661 tacagctgaa taataagtag aaatactttg tacataataa aaggcaggaa tcctggaaac
     6721 agattcctgc cttttttgtt tatatcttag aagtaacgat tacttctcac gaagatattc
     6781 attaaaactc taaagatatg atcggatttg ttatttggat tatcggtttg atactgactt
     6841 tcagagctgc catagagatt tggaatataa atgcggctgt agagaaaaga cttatagcga
     6901 ttgtattaat cgttcttacc agctggctgg gactactttt ctactacttc tatggtaaag
     6961 aaagaatggc gggatggttg aagtagtgtt tgcatatcaa tctttctcag gaatccaact
     7021 gttcaccagt tcctgatgtt cttccatcca ttgacgggca gcctgtcttt ccgttgtctg
     7081 cgcctcttcc agagcagtca ttaaggagct gatttccgca tctgtcagac gaatgttgcc
     7141 caaaagttcg gcagcaaaag ggtctttctc gctaaaacct ttccatgcta tggtatgaat
     7201 ggattccgta tttccatata tcagcttcgg gtcctgaaga actttcagct tgaaacggtc
     7261 gaacatccag tgaggcgtcc atcccgtcac gacaatccag tctttcttat caatcgcttt
     7321 ctttagggaa gcagtcatgg caggtccgct cgaagtcatc agtttataat ccaatccata
     7381 gtctttgatg gcctgatcgg tagctttcat aataccggct ccggcatcaa taccgacaat
     7441 ctgaccggag aaacgttcct tttccgcgtt cagttcttcg attgagttga tcgtaacgta
     7501 atccggaacc accagcccga tacgggcacc atcataaata tccccgataa cttcgagttt
     7561 atccccgtat tgtttcatat aatcttccat agtgacaggc atccagacat ccataaatac
     7621 gtctgctttc ttacgggaga tagaggtaaa tataggtgca aggtcggcat tcagcaactt
     7681 tacatcgtac ccctgatctt caaaaatcgc tttggcaagg tttgtcattg caataccttc
     7741 cgaccagttg gcataagcga tacttatctt cttactcttt ccgttgtctc cgcaggaaac
     7801 gaaggttaag agtatgccgg caataaacat tgccgcaatc atttttatct tattcattga
     7861 ttattccttt ctttggtgtg attcttattt ctttttactt tttctgttat ctgccatacc
     7921 ctgagtgatg cggtccagca cgatcgccaa tatcacgact gcgataccgc cttcaaatcc
     7981 gagtccgatt ttcatttggg tgataccttt cagcacgatt tctcccaatc ctccggcaga
     8041 aatcatggca gcaatcacta ccatcgaaag tgacatcatg atcgtctggt tgattcccgt
     8101 cagaatagta ggcaacgcca aaggcaattg caccttataa agaagctgcc agggagtagc
     8161 tccaaaagag cgggaggctt ctactacgtt tttaggaacc tgacgaatgc ccagaccggt
     8221 cagacgaacc acaggaggca ttgcaaagat gatggtggca aaagctcccg gcacagttcc
     8281 caatccgaag aatagaacgg caggaatcag atagacaaag gcaggcattg tctgcataaa
     8341 gtcgaggaca gggcgcatta tcttgttaca acgatcactg ttggcagtcc agattcccaa
     8401 cggaacgcct aaaagcaatg ccagacaagt ggaagaaagt accaatgcca atgtctgcat
     8461 cgtttcttcc caaaagccca tgccgtaaat aagcaataaa cccaagaggg taaatacggc
     8521 tgtcccctta cccgacttaa accaggcgag cgcagccagc actgcaattg tgatataaaa
     8581 aggtattcca aacagtacgt gctgaaaacc gtctatgaat cctccgatcc ccatgctgag
     8641 agcatcaaaa aaggaagcaa aatgttctgt gagccaatta atggcagtct ctatatattg
     8701 tccgatattt atcataattc tattgcgttt tgaatgattt cattaatttc ttctttatct
     8761 tttcccgtta cttcgatgat caatgaggaa agtggcacta cgccttcaaa ctcccgattc
     8821 tcatttacga cccagattgg cgagttcgtt tttgtcatca acggaagaat atcttccagc
     8881 accgtatcac ccagcactga atgaacttca tgccttacta cggactcgat ggagcggatt
     8941 tgctcttttc gtagtttcag caagtcattc aaccgcacct ctcctactaa cagattattg
     9001 gaatcgacta ccggaagaac ggtcagattc cgttcgcgca tcttacggat cagcacctcc
     9061 gggccttctt tcttcaaacg tgccactatg ggtttatcta ccataacaga ggaagctgtt
     9121 ataatcttgc ttcgatctac attctccaca aatcgttcta cataagcgtt ggcaggttcg
     9181 gtcaggattt cttccgatgt accgatttgt acaatttctc catccttcat gatagcaatc
     9241 cggtcaccca atttaatcgc ttcactcagg tcgtgagtaa taaagacaat cgtttttttc
     9301 atcttcgact gcaaagtcag cagttcatcc tgcatctgca cacggatcaa aggatcgagt
     9361 gccgagaagg cctcatccat caacaggact tcgggattat tggccaaagc ccgcgccagc
     9421 ccgacacgct gctgcatccc acccgacagt tcacttacca tctgattctc gtagcctttc
     9481 agccccacca gttgcatact ttccatcgct ttctgctccc gttctccctt ttttactccc
     9541 tgtagttcga gcccgaaagc tatattatgc aagacagaac ggtgaggaag cagaccgaag
     9601 ttctgaaaga ccatagccag ttctttccgg cgaatctgca acagttcctt atccgacact
     9661 ttggctatgt ctgttccatt gataatcact tctccggaag tagggcgtat caaacggttg
     9721 atgcagcgga gtaaagtgga ctttccacta ccggacagcc ccataatgac gaatatttcg
     9781 ccttcattaa tggaaagatt cgcatctttc accgcaactg tacatccggt cgctttcaat
     9841 atttcacttt ttgttttacc ttctttcaac atcttcaaag ccttctgctt ctcattgcca
     9901 aaaaccagat agagatcttt aatttctatt ttactcatac aataaaatgg tttaggttat
     9961 taaaataata tacacagcaa gacaagaaca aacgataaca ggaatctttc tttatatcgt
    10021 ataaagttct gatttaaata agggacaaat aacaatgaat cccgaaataa ttaataaaat
    10081 gattattgac agactgagta attaaaaaag gaatagaatt tgataagata atcctttcaa
    10141 cgaatagcaa aaaatagcat ttttatgtat aaaaacagcc tgttccagta tcttgctggc
    10201 acaaagatac aaaaaacgga ttaaacatac aaattatatt caaaatccgg ggcatacaga
    10261 gggctttatt tgtaatgata tggaaagttt ccgggtaata ttcccctatc actcagcaaa
    10321 atagaacaaa ccggcagata aatataaaat aagtttgaat atttcactta aacaccgtat
    10381 atttggcgtc aataactaaa ctagatttat atgttcaaca gggctattac aattttcctg
    10441 gggaaggata attgtcatta cacaacaaaa gaaaaacaaa caggtactgc cacactagac
    10501 gacaaaagcc aagtacagtt ccttagtaaa aagaacccca aaatgccgtt tttctatagc
    10561 cggcggaatc tctacatgat aggtttcctg ctcgctttta tagtgactct gctcgaattt
    10621 atacgaggac ggcatcaaaa ctttatggtc ttctcggacg ctactcaatt cttctggcaa
    10681 ggcatcagcc catacacaac tgaatttgta gaagctcacg gacgctactt cctttattct
    10741 ccagttttca cggtattgtt cgctccgttt gcgtatctgc ctgcatggct gggacctttc
    10801 gcgtggaatc tattcaatta ttcgctgttc tttatggcga tcttcacgct gccccaacaa
    10861 ttcacccagc agcagaaatg ccgtatgttc ctttttctgt tactgatttt aggacaaagt
    10921 ttactttcat ttcagtataa cataacggta gcctatttat tcttattcgc ctatacgtta
    10981 ttggaaaaag accgtggatt tctggctgtt ctgttaatca tgatttcggg atgtaccaaa
    11041 gtatatggaa ttttcgaact ggcattgttg ctgtgctatc ctcacgtatg gcgtaacttt
    11101 ggctatgccg ttacaatggg cattgtattg cttgcattac cgttaataaa aatagctcct
    11161 gcagatttgc tcccctatta tgaagaatgg tgccatagtc ttgctgttca tcagtccgcc
    11221 ggagcttatg attcattttt ctatgcccgc cccattgcag catggacatt gccacacttc
    11281 cgtgcacttc agataggaat gctcggcttg ctgactctgc tctttttggg gaatttccgc
    11341 aaatggtcgt cttttgcctt ccgtgcccag gctttgggca ttctcatggg ctgggtagta
    11401 ttactgagtg actccgccga gaagcatacc tatattatcg cattggcagg tttcatgctc
    11461 tggtattgga gcagaccaac acgtaccgca acagacaaga ttctattttg gtgctgtttt
    11521 gtgctgttat gtatcgttcc tatcgacata ttcgtccctg tacccatcag agatttcatt
    11581 accaggacct tatggcttca tgtatgggtt ttctttattg tatggatacg gatgatatgg
    11641 cttaccttcc ttgcatcctt cattcatcca cgtgccacaa atgttctttc agattaacgc
    11701 atccgttagc tttgaaagaa acttcttctg ccagcaagag ttgtttttgt tccacccaac
    11761 cgggcaccag ccttccggtg gaatttacaa ctctatggca gggaatggat aattcatccg
    11821 gcacttcttt caatgcacgt cccaccatcc gcgagcattg gggtgccccc aacagcaaag
    11881 caatacctcc ataagtagat acttttccca caggtatctg ggatacgact tcgtacactt
    11941 ccttccgaaa ggattcggaa aagctctctt tatctacttt ataatctttc atatatccct
    12001 ctttacgata tcaatgaaat catcctttcc ttttcaggaa atctgtcggg ctctctccaa
    12061 actgctcttt atagcacttg gcgaaataag aaggtgaact gaaaccgact tcataaccaa
    12121 tctccgctac ggtcatgtcc gaagaagcaa gcaaagaagc tgccttcttc aaacgggcga
    12181 tacggagcaa ttcattcgga gagtagttag tcaatgattt aatcttgcga taaagctgca
    12241 cacggcttag tcccatgtct ttgcccaagt cctccacatt caaaccggag tctcccattt
    12301 tctcttcaat caatgacttg aatctttcta caaaatcctt gtccatatcg cagacatctt
    12361 cttttgccaa tgtctgcccg tcaccaaaga actgtttcag acgacggtga gaatcaatca
    12421 gattgcggac acgtgccagc aacagctgtg aactgaacgg ctttgaaata taagaatccg
    12481 caccaccgtc atatccctga atacgctgtt cgtccagtga acacgctgtc agcagaataa
    12541 ccggaatatg acaggtctgt aactcacttt tcagccggcg gcaacattca atgccatcaa
    12601 tgcccggcat catcacatca gaaatgatca ggtccggaac atacttcata gccttacgga
    12661 ttccttcgga gccgtctgcc gcttcaatca ccgtatagtc tgtatgcaac aacgtatgga
    12721 catacgaacg gatatcctca ttatcatcaa taatcagtac ggacggtttg gaagagtcat
    12781 atcctttttc cagttcttcc tcttccgcca atagaacatc tgttgtacgg gaatccgcag
    12841 aaacaagggt ggtatccggt ttggcagcaa cagcctcaca agactgtacg ggcagttcaa
    12901 cggtaaagac cgtgccctgt ttctcatcac tctctacgga gatcatacca ccgtgcattt
    12961 ctacgaaggc ttttaccaat gccagtccga ttcccgaacc ggtatggtgc atatcgatct
    13021 tatagaaacg gtcgaataca ttgcgaatat gttcggcaga aatcatggaa ccggtatttg
    13081 ccaccgtgaa acgtatccat cgcttgtcct ctttactaag ggaagacaga cggacggcta
    13141 ttttcccgtt ttccggtgta aacttaaagg cattggacag aagattgaaa taaatacgtt
    13201 ccagcttctc catgtctgcc agtgtatgat aatccgtatc cggcatacta tcaaaagaaa
    13261 aatggatatg cttcttacgg gctgccgcct gaaaagactc attccatcct tcgaaagaag
    13321 aaaggacatc caccgtaacc ggagtatatt ccatcttgcc gttttcatat ttacggaaat
    13381 ccagaatctg attgaccaga cgcagaagga tattcacatt tcgctgaatc agcatgagca
    13441 tccggtgctg atctccactc aatgtcttgt ccgccaataa atgttctacc gggtcggcaa
    13501 ccaatgtcaa cggagtacgg aagtcgtgag aaatattggt gaaaaagacc agcttggcat
    13561 gggtagcttc ttccagttga tgagagagct gtatcaattg gtcacgctgt tcttccagtt
    13621 tgtcacgctg ctcttccaat tgctgcttct gcttaaaaag ctctttattc aagcgattct
    13681 tagagcggag tgatttataa acgaccaata ataagccggc taccaataaa aggataatca
    13741 gactgccgta taaaactacc tgttgtgtag ctacctgaga gaggtatcca ccgatacgtc
    13801 cgttgagcgt ttcaatcttt ttatcgagtt cggaaatgtg tgtggtctgc aactgcatga
    13861 cgtgtgcgtt ggtacggtcc acaacagcgg tattcatcac cgtttctttg ggatagggtt
    13921 tcttctccag aatgtccata gccagttgca gtaccttatc gccattggtc ggatagataa
    13981 aggtggcatc cagcacactg tccagtacca gttccagtcc gtttccctta cccggcaagg
    14041 catctatgcc gacaaaaatc atttccttct cccgccctgc catctttgct gcctgatagg
    14101 cacccggagc gatacggtca ttatgggcat acacagcatc aatcttagga tgcctccgaa
    14161 gcatactatc catttctatc tctgccggac cacgttccca cgcagcatcc gctttatcaa
    14221 tcagctttat atccgggaat ttactgatgg cagccataaa tccctgatgc cgttccattg
    14281 caggagtcga accgctcaat cctgtcagtt ctactatatt tcccttccct ttcagactgg
    14341 aggcaatata gtttcctacc gaacgaccga tttcataatt atcggctccg atataggcag
    14401 tatatttatc cgaaagaatc ttccggtcta caagaataac ggggatgcct ttctgataag
    14461 cttcttctac aatcggagtc ataggagcag cttcgttagc ggaaataatc agcagatcga
    14521 ctccttcgtc cataaaataa tggacatctt ccgcctgctt actgttatca tcccctgccg
    14581 aacggatttc caccgaaacg ccattataaa acattgcttc ccgaagaatc tcatcattca
    14641 tcttatgtcg ccatgaatca tcgctgcatt gagccacccc aatacgaaaa tggggtgtat
    14701 cctgccggca agccgtcatc ccgattaaac caaacagcac cagcatccac ttcagatatc
    14761 tcatcgtctt catccatctc atcatttcat agttctttct gtaatccaat taagaacaaa
    14821 aataagaaat aatactgtaa agttctctaa cttcagctat ttattattct aaaaagaagg
    14881 aaagcagtcc tctttcagac catcggaaag tattaacaaa agtataaagc gtaaaacaaa
    14941 cacttaatca atgttataaa acatagcgtt ttacttggat aatttgcaga tttcacagaa
    15001 gtccgtatct ttgcactgtg tttttcatag tattagattt aaggttaaca aaggttggag
    15061 caaggcgttg ctcctttttt tatgccctga cctttcatct accggttagt tttcatccca
    15121 ttccttttcc agtttaccat caatagtgta gcgtttccat cgtcctacac ggcgaccatt
    15181 cttatattcc ccacattcac gaagctggtc attctttaca taacgagctt cgaacggtcc
    15241 gttctgcctt ccgttcacat aggtagaagt ttcccaataa tcaaagcggt tgctcactat
    15301 cagccgtcgt tccttgccat gcaatctgcc ggcctgatag gtagcttcat atctcaattc
    15361 accattttcc agattatatt cacggtataa accgtcttta cggtcgttct tcatataata
    15421 ttctttctgc cttaccccac ttccattggc aaatgagaca tggagtccat cttcttttcc
    15481 atccagatag gtttcaatca tcagcgtatc gccgctttcg gcaaaagtag tccaccgacc
    15541 attcttcttt ccattcttat aactacccag tatacgtggc gagccaaacg taaacacgga
    15601 cgaatattca ccgtcctgca aaccttcttc attgaaataa acggtctcat acaaatcata
    15661 agtacctttc agaaaagtat actgtttgcc tacctgcttc ccgtccttgt aattatgctc
    15721 tttccgcaaa gtaccgtcag attcgtacga cagttgcttc ccgtgctctt tccccatccg
    15781 gaagtttctt tcactttcca cttttccggt agtaaagtaa cttttgctcg taccgtccag
    15841 cttaccttcc ttataggact tttcttcttt cagcttaccg tcaaacttgg agttaatctt
    15901 gaagaggcca tccttccgcc cttctttata acttccttcc gttattaata tattgtccac
    15961 atattctttg tatccgccat cataaaaacc atctttaaaa gatgccagca cataggcgga
    16021 atgataacca tctatgatgc gatgttcgcc attcaatgct ttttccgttt tcagttcctg
    16081 aaacaacagt ctgccatcgc ctacattaac aacagatacc tgatcgatct tatattcttt
    16141 ttgcgcaaac aaaggaagag caagatataa aaacaaaaat acgttccagc tttttgatct
    16201 gaggaagttc gaaatgtgtt tcataaagta gttttctctt tttgatttat tatttaaaaa
    16261 cctgccgcaa agataggcaa tcggcttata aaacaaggca aggaagaggg ggacaattag
    16321 aaaaaagaac atctgttatt atcattctaa taattaacag attaagtagt aaatcaaaac
    16381 acagggaagg gggacattta ctgaaataag aaacagaaaa gaagatgtgt caaaagcaac
    16441 taaattcccc tccttcggga aggaggagag tttagttgct tttgacacac cttctttttg
    16501 aatttaaaga gattctacaa caatctgtct ttcagaacta ccggaagttc gggcattgca
    16561 ccgctctgcg tacaaacata agcggaaact tcgacagcca gcttatgagc ttcgggaaca
    16621 gacttgccat tcagaatgga agcacagaaa gcggcagtaa aggaatcccc cgc
//
