LOCUS       gnlProkkaLOHCBLIL_196  13102 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LOHCBLIL_196.
ACCESSION   gnlProkkaLOHCBLIL_196
VERSION     gnlProkkaLOHCBLIL_196
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 11:55:46
            Original ID  :: gnl|Prokka|LOHCBLIL_196
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 53900
            Orig. end    :: 67002
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13102
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12954]"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12954
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /neighbourhood="10000"
                     /product="sactipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13102
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="interleaved"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..13102
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="sactipeptide"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(subtilosin or thuricin or TIGR04404 or
                     Subtilosin_A or skfc)"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(646..1830)
                     /locus_tag="ctg151_61"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAVFRNVTFHVEVEAENEKVYQRGQVNQQLQVLLNRNNIYIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSTQFSEEAYQKYQ
                     AAREMYEVTGYQLKDLEVIDGRYITPDGRDLLDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGVNY"
     protocluster    1488..13102
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[11487:12720]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      11488..12720
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="2"
     CDS             1962..2819
                     /locus_tag="ctg151_62"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLFTFTYSASAVGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     IAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTS
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     CDS             2905..3675
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 111.8;
                     E-value: 6.8e-34)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg151_63"
                     /sec_met_domain="Pkinase (E-value: 8e-34, bitscore: 109.4,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLNSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     CDS             complement(3668..3859)
                     /locus_tag="ctg151_64"
                     /transl_table=11
                     /translation="MTDIADTGITAAAGADIIAATAARAKEDTTTVMAAVIVTNAGATA
                     AVNPKKFLFRFWDKGFFM"
     CDS             complement(3978..4964)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 59.4; E-value: 5.8e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg151_65"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKAADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKMEVTIEHDNVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDSGTGFLFSKE"
     CDS             complement(4961..5632)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 127.4; E-value: 1e-38)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg151_66"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     CDS             complement(5634..6611)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg151_67"
                     /sec_met_domain="PF00561 (E-value: 1e-08, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVCVSVFIYHHFQLNREAALLKEKG
                     TLVEVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRETHSIYLYQPDQIYKLSMEFMRKVR"
     CDS             complement(6860..7285)
                     /locus_tag="ctg151_68"
                     /transl_table=11
                     /translation="MKDEQMLTEWPSHLPWLNQSQNDFTFPSDTYLLLYFWSMSCPNCH
                     QLTDKVLQDIKDMNVKVIGVHVPYIEEEKSMEVVLTYALDRGLAIPIVLDQNYEIVTTC
                     HVQGIPSFCLLSQYGQIITKTMGDVGWDKMLKKIAGL"
     CDS             complement(7290..7805)
                     /locus_tag="ctg151_69"
                     /transl_table=11
                     /translation="MNSNGDKLSLSVQNLANTNEITIVQAIGELKKSGKDAIPVLVEAL
                     KEEGSLCNIAAAVLGEFGEDASEAAEELSCLLKSHAEDTRMAAAISLMRIGKPSLPFVI
                     KIAQESEGQSCFWASWCIAWIDPSCIEPKMYKCLKYEHEHPSGIVAPFAAEEALGKLIA
                     FQLKDKED"
     CDS             complement(7852..9267)
                     /locus_tag="ctg151_70"
                     /transl_table=11
                     /translation="MNNIISFLWLQSKRRFVSQGQEKKMPFLIMLLFVGAIGFQVSFVS
                     RSTTWDMSIAGWVLTGVFILYTAFGLFSNRLPSQMADIIWLYGTATSFSKVVYSVLFFS
                     VTWKALLWIISAIFGDVLIVLLSGEHINLLGRSIIFIGLFFIAEVWLMSVSCARTVKKM
                     KRVYVSVFLLMLGIYSICLYQFFFLQHSSGIWESIARFISGVGLVFDTLSPLYVVVFIG
                     IITVSFMTIAFTSRQVEMRESLVKEAEFWEEFQERQFGSGQIIQKPKTTWWGLQGLNGI
                     WSFLWLELLLFKKYLFFHSIHTVMLSGVFYVVIFMYPEWFYLLFFLIVSAVMLSSYYSG
                     IVRHSQSGTLHLFPGALWKKIIILELTNTVWLYILYCVSITFMAVGNLVYWYIYGLGIY
                     IWFMTIRLFAFTHTNRNDIKLSLPQYYKSFFMALGLSGICLYVIHLLTADWYTLVVVVC
                     IGSLSWCLFYRFR"
     CDS             complement(9260..9982)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 176.6; E-value:
                     1.1e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg151_71"
                     /transl_table=11
                     /translation="MQLMQVQNLSKCYRNGDGVEHLSFSIQRGEIVALLGPNGAGKTTT
                     IRCLTGLYKPDKGDILIEGSPPGHINVQKKVALIPDQPYLYPALTAAEHIQFRARGYHP
                     GKKDVKERVYHALKEVHLEEKANQLCGQLSRGQKQRVVLAGAIVQDALLYILDEPTVGL
                     DIPSKQWLSNWLKTKTDQECSAFVSTHSLEFVLETADRVILIRDGKLMQDLYVPQFEEE
                     QAEWRKEVIRLLGEWSDE"
     CDS             complement(10001..11491)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: skfc"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_72"
                     /sec_met_domain="skfc (E-value: 2.4e-288, bitscore: 949.3,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Abi (E-value: 1.9e-14, bitscore: 46.1,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSLSLVFWSILAVVGLLLFIKFKPPTIASLLLSKDEAKEISIQF
                     IKEFVGIDVENWDFYSVYWYDHDTVNKLHHLGILKKNRKVLYDVGLVESWRVRFVHQNQ
                     SFVVGVNANREITFFYADVPKKTLSGKFEQVSPETLKQRLMASPDGLWSRANMTGTGKK
                     EEDFREVSTYWYIAEAGDIRLKVTVELQGGRISYIGTEQEILTDQMSKVIRDEQVESTF
                     GVSGMLGSALAMILAILILVFMDVQTSIIFSLVLGLLIIIFQSLTLKEDIQLTIVNAYD
                     ARMSVKTVSLLGILSTLLTGLLTGFVVFICSLAGNALAGDFGWKTFEQPIVQIFYGIGA
                     GLISLGVTSLLFNLLEKKHYLRISPELSNRTVFLSGFTFRQGLNMSIQSSIGEEVIYRL
                     LMIPVIWWMSGNILISIIVSSFLWAVMHQVTGYDPRWIRWLHLFIFGCFLGVLFIKFGF
                     ICVLVAHFIHNLVIVCMPLWQFKLQKHMHHDQPKHTSL"
     CDS             complement(11488..12720)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_73"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     4.5e-16, bitscore: 51.4, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.7e-23, bitscore: 74.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 8.6e-08, bitscore: 24.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 8.8e-07, bitscore: 21.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYDRVKDFDLPELAVHLQPHGAVMIDRKSMFYFRLSGRGAQLAF
                     LLSKNKNLHKTARIWEIMKKEEMSADQLKEELSAHPFTEAWTEGLLDQPLHVSGSLDSY
                     LPISCTLQLTNACNLSCSFCYASSGKPYPEELSSEQWILVMQKLAAHGVADITLTGGEA
                     KLIKGFKELVVVASSLFTNVNVFSNGLNWRDEEVELLSHLGNVSVQISIDGMDNTHDQL
                     RGRKGGFKESMNTIKKLSEANIPVIVAMTINESNADEVSDVVEQCANAGAFIFRAGKTL
                     SVGRATEGFKALDIDFEEMVQIQLREARHKWGDRLNIIDWEHEESSFTTDFCTPGYLAW
                     YIRADGYVTPCQLEDLPLGHILEDSMADIGSPARLLQLKCEAKNCKCIGKIELSEPDLP
                     FQKEVKAGIQE"
     CDS             complement(12787..12954)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     sactipeptide: TIGR04404"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg151_74"
                     /sec_met_domain="TIGR04404 (E-value: 7.9e-39, bitscore:
                     123.7, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNQKEWESVSKKGLMKPGGTSIVKAAGCMGCWASKSIAMTRVC
                     ALPHPAMRAI"
ORIGIN
        1 aatacttcat ataagaaccg acagcgataa tttctgacat gccgacgata atccactgga
       61 accagttgct ccatgctgtt atataacctg ccatcggatg aatatattga tggccgaacg
      121 tcgcaaaaga acctgtgctc ggctcgacat acagcatttc acccatcgca cgcataataa
      181 aaaagataaa aattccgcat attgcataag ccagaaggac agatgggcca gtccatgaaa
      241 tcgtgctggc agaacccata aacaagccaa caccgatcgt accgcccaag gcgatcatct
      301 gaatatggcg cgcgcccagg cccctcttta attctttatt tgccactcct cttcctcctc
      361 ctaacaaaat actcataaat gagaaaacag cagacctgct tgccttcaca tgaatcagtg
      421 ataacaatca gaaaattcaa acttaaaatt gttatataat ctcctaaatt acttatttca
      481 tcataataaa tttctctgga aaatacaatt gtttnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnttatata aaaataataa aattgtttga atattgaaat taatatgccc
      601 cttagattct cataaaaaat aagctgttct acatgaacag cttacttaat aattcacacc
      661 cgtttgacgc tttaatgctt caagccaccc ggtatctccg gtcccatagc tcttgctttg
      721 tcccacatct ctcagagatc cattgctgta atcaattgat aggatgaaat ccggaatggc
      781 attatacccg gcttccgcga ttttactgag ctctgaacga tagtaagata tagcataaga
      841 agccgtttgt ttctgcactg gatctttttc aagctcttcc ttatatacat ctaataagtc
      901 acgtccatca ggcgtgatat accgcccatc aatcacttct aaatccttca attgatagcc
      961 tgtgacttcg tacatctcac gagctgcctg atacttttga taggcctctt cggaaaattg
     1021 tgttgaatca ctgctttggc ttttcatgat gtgcaaaaat agttctttgc tgttgtctcc
     1081 agattgcagc acttgctcaa tttgcttgat cagatcctgg tcgtctgtcc cgctcacccg
     1141 cacctgatag tcaatcggtg tgattgtaaa cgtcagctct gtcccctctg gaatataaat
     1201 gttgtttcga ttcaacagca cttgcagctg ctggttaacc tgtccccgct gatacacctt
     1261 ttcattctca gcttccactt ccacatgaaa tgtgacattc cgaaacacag catcctgaag
     1321 gttatagttt tgggccttgc ctttgaatag ccattctgtt tcattatcgt aagcggcctg
     1381 tctttctgca gctgacagat cacttctgaa ataaggagac tttgaatttt ggtacttatc
     1441 cttaatatag cctaatggat cagactttgt tttgttaatc gcattcatcc tgctgtattt
     1501 ttcatctagt attttgattc tgatatcact ctcagattca taggggtttt gggattgaat
     1561 cactgtttct tcccctgtgt ctgtcactgt tcgatcattc gctgattgat acactttgct
     1621 gaacgtcccg ctgtttcccg acacgctggt tttagaataa ttgaactgat tgattccccc
     1681 agttgaagat tgtgacttaa gcctgctgta tgccttttcc agaactgccg ctggattttc
     1741 agtcgcattc tcccgtttgg caggcgcatt cttgctcaat atgttctgtg ccatcagctg
     1801 agtgcggata aattgccgat tcagacgcat tgaattccct cccgagtatt ctctcttatt
     1861 cttttttatc ggcaaagata atgtatatat taacctcaaa aaacatttat ttacacctaa
     1921 atcgttatta tgtatgatgg aaataaaagg aggttgtttg catggtgaaa aaatggctta
     1981 ttccattcgc tgttatgctg tctgtcttat tcacctttac gtattcggca tcagctgtcg
     2041 gagtcactgc tatcacagga aacaattcat ttgataccgc aatgccgatc ggttattgga
     2101 aatataaaaa tatcgataca acaatactgg aagctggtca agatgaagcc tatttcactt
     2161 ttacggctaa taagggagaa aaagtatacg tgaggagtac ataccagagc gcgtatacag
     2221 ggatgaaaat tgaaatttat gataagaata gaatacctgt ttctcaaggg acagaagtca
     2281 ttaaccctaa tacgttttct tcttttattt atgcaaatgc agacgcccaa aacacgacgg
     2341 atacctttta tgtgaaagtg tcacgaggca cctataccgg aaacatgtat tttacacttt
     2401 caattgaaga ccgaatcaaa tcaggcagcg gaacattcca attcagcggc attgctgaaa
     2461 ataaaggaaa tacaagcctt agcccctcag gttctgactc cagcgtgatc aaggttgatt
     2521 taacaaacca atctgggata ccgcgtgatg ccattgtaac cagagttcag acaaccgcca
     2581 ctcaaacacc aagccaggga aatacacgcc acctgatcat gacgagcgaa aacaacgaat
     2641 ggcgccgtgc tcttgtaaac agctcgactt cagggtctta tgatatctct ttgtcagatc
     2701 aactcagtgt ggcaaaggta tggagtttta aatataatac attagcgact gccagatcga
     2761 cgatgagcaa cgtaaaagca aaaatagatt atgaatacga cgtgacaaag cagttttaac
     2821 ttataccgag ccggtgatcc ggctcttttt tattctccgt ctagaaggta aactatagtc
     2881 agtacaacca agggaagtgc agacatggca ttaaaacttc taaaaaaact gctatttgac
     2941 cgccctctaa agaacggcgt tatcttaaat catcaataca aaatcgaaga gtgcctcggt
     3001 atgggaggct acggtttggt ttatttgtgc accgatatcc taactcaaac accttatgtc
     3061 ttaaaacagc ttcggccgac aaaagcgaaa aaggaaaaag agaaagtccg attccaacag
     3121 gaaataaaac tgctcaatag cattcaccac ccgcaaattc cgggcttcat agatgagttc
     3181 atcatagacg gacaggctta ttatgtcatg cagttcattg agggagagaa tatagaagaa
     3241 ttattatttt ttcgaaaaca gccgttcaca gagcttatgg cattacaact gatttcgcag
     3301 ctgcttgaga ttatagaata cctgcatgat cgccttatct tccacagcga catcagaacg
     3361 cctaatatca tcatcaatga tggcaggctc tgcctcatcg atttcggcct tgccaaacaa
     3421 ttgactcctg aagaaatgga ggaaataaag gtacgaaaac aggatgactt cttcgatctc
     3481 ggagaaacgc tgttattcct gctgtactct caatataaag gaaaaaagaa gaaaaacggc
     3541 acttggctgg aggaattaac actgacaaag gaagtaacct tgctgctgaa aagattattg
     3601 ggcattgagg aagagtatca gcacaccgct tccattcgcg aggatctaaa ccgggccatt
     3661 caatcggtca cataaaaaaa cccttgtccc aaaagcggaa caagaacttt tttggattaa
     3721 ctgctgctgt agctccggcg tttgtaacga tgactgccgc cataacggtc gtagtgtctt
     3781 cttttgcccg agctgctgta gctgcgataa tgtctgcgcc ggctgctgct gtaatgccgg
     3841 tgtctgcgat atcggtcact agaactgctt gagaggtact taatcgtttt gatgattttt
     3901 ttaaacatat gctgttcacc ccatttcttt ctccctatta tataaatttt ataggagaaa
     3961 gaaaaacatc agcggggtca ctcttttgaa aacaagaacc ccgttccgct atcatttgta
     4021 tgcagctcat aagtaatcgc aagcagcctg catgtatcct caataatctt taatccaagt
     4081 ccctcactgc tctcattccg atcaaatcca ataccgtcat cacgaataaa aacattgtca
     4141 tgttcaatcg tgacttccat cttttcagct tttgaatgct ttaacgtatt ttgaaaaata
     4201 ttatcaaaca gcctttgcat ccataacgcg ttgctcatcc atatcacatc ttgatctgcc
     4261 gccttatagt gcagctcaat cccactcata ctgtataaat aatcccactt tttcaccgct
     4321 gtttctaata gctcgtttag acgcacttct tcatttacaa tataagagct ttccagcgtc
     4381 tcagcggaat atagattgaa ttcattggtt aattccgaga tatattcgat ttgctgatac
     4441 aatgattcga atacagcctg accatgacat tggtcttcca aataaaataa ctgcagcctg
     4501 agagccgtta aaggtgtatt aatgtcatgc cgcagttttt gcaaaagctc ctttttgatt
     4561 tcctcttgct gtctcagctc cagttcacga tatgtcgtcc gttcaattaa caaattgacc
     4621 gacttgatca gttccccgat ttcatcagca cgcttcactt caattttatc gggcaccctt
     4681 tgatcactcg ccaaatgccg aatggtttga tttaatagat tgattttatg caacagagaa
     4741 tgaatcgact ttgaaaataa aaaagctaac aataagagcg atatcaaaaa tacaacgatc
     4801 attgccgggt acgcaaacga cctgtgaaag ggcataccat gattcatcgg tttaaacatg
     4861 ctgtcataaa taacagacat caaaacactg accgccagca acagcatcgg aacactaatg
     4921 acagccgtaa acaataacaa ctgatatttt gtcttgagct tcatttcttc acaacggtat
     4981 tcagccgata cccttctcca tatatatttt caatcatctc acccgcttga tcattgattt
     5041 tagctctgat ttttttaata tgcacattga caatattcgg gtttctatct tcgagctgcc
     5101 atagatattc aaagaaatgt tcctttgtca ggatactgtc tctattttca tataaataaa
     5161 agaaaatttt ccgctcaatc gcagtaaata atacctcatc atgcaggctt tcattgaaca
     5221 cttttttcgt tactgcatca atatacaaat gtttgatttg cgtaaaggtg ccataatgat
     5281 gctcaagcat attccgcatt cttaatagca gctctctcgg atcaaagggc tttaccatat
     5341 aatcctcgcc gatctgcaaa ccttgaagct tgctgtccat gtcattgcgg gctgagagaa
     5401 aaataaccgg aatgcccagc cccagctctt tgatttttgc agacatttga tacccgtctt
     5461 cacccggcag catcacatcc ataatgacca aatccacctt ctgaatcacc gaaagcacat
     5521 ccgccccatc tgttttccat atcacacgat atccctcacg ctgcaaaatc ttttgcagca
     5581 aatcaccaat catcacatcg tcttcaacga ttaaaatatg ataacccttc atcctagcga
     5641 acctttctca taaactccat ggacagttta tatatttgat caggctgata taaataaata
     5701 ctgtgtgttt ccctcagttc ctttatatcg gcagtattga attgagccgc aaacgcttca
     5761 tagtcttttc ggttttgtat agcatacttt gaatgtctat tttggtcaga gaccgcatct
     5821 aaaatcaaga cgggagtttc ctttggcgcc ggcagattca cagatttgct gccgttttgg
     5881 taagactgca aaagctcatg ctccatatct gcattaaaaa attgcttaaa gttaatggct
     5941 ttatagattt ctttttcttc atcagttaaa aacgactgcc gaatcacctc aggattatat
     6001 acagcggaag gtataaaccg atgaaaacca atcgaggtta acaggtggaa ccctctcact
     6061 ttcaatcggt caactccgct caatttatac gtgacgtact gctggggcaa tccaatatcc
     6121 atcgcaataa tggccttgat ttccttagga tatttctgtg cccaatacat cgcttcaatc
     6181 ccggatatcg aatgaggcat taaaatataa ggaggcttat ttccgctttt cataagcgct
     6241 ttcctcgtct gttccaatac cgtatcaata tctctgtcat cgtgagacac ttcactgtat
     6301 ccataacctg cccgatctac aacagcaatc ttattttctt ttgaaaactt gctgtacagc
     6361 cccttcattt cataagcagg cgcagcaatc cccgaaccgg acataaacac aaacgtatcc
     6421 ttcccgcttc cctcttgata cacattcatc tttttaccat caacttcgac taatgtgcct
     6481 ttttctttaa ggagtgccgc ctccctattt agctggaaat ggtgataaat aaataccgag
     6541 acgcatacaa gcaaaaccaa agcagccaag ctgacaaaaa caattttgag gactttccat
     6601 aatgttttca tatgatgctc ctttcacttg atactgaaaa gatacaatat gaaaataaat
     6661 ttctgattaa ctttggaaca gttttatttt cacatttaac tttgccctta cggaaaggtg
     6721 tacatttgga gcatagcaga acatttgatg aatttaccta ctaataaaaa aatatttcat
     6781 aaaaaaacct tcctgcttat aggaaggacc gtttcatcat aatattcaac cgtttgtcgc
     6841 acatacaaga cggaaaattt cacaagcctg caatcttttt taacatctta tcccaaccaa
     6901 catctcccat cgttttagta atgatctgac cgtattgact taatagacaa aagctgggga
     6961 tgccttgtac gtgacaagtt gtgacgatct catagttttg gtctaataca atcggaatag
     7021 ctagtcccct atcaagagca tacgtcaaga caacctccat agatttctct tcttctatat
     7081 aagggacatg tactccgatt actttcacat tcatatcctt tatatcttga aggactttgt
     7141 ctgttaattg gtgacagttt ggacagctca ttgaccaaaa ataaagaaga agatatgtgt
     7201 cacttggaaa tgtaaaatca ttctgtgatt gattcaacca tggtaaatga cttggccatt
     7261 cagtcaacat ttgttcatct ttcatccttt cagtcctcct tatctttcag ctgaaaagca
     7321 atcagctttc ctaatgcctc ttcagccgca aacggagcaa ctattcctga aggatgttca
     7381 tgctcgtatt ttagacattt atacatctta ggttcaatgc aagacggatc aatccatgca
     7441 atacaccaag atgcccaaaa gcacgattgc ccttcacttt cttgagcgat tttgatgaca
     7501 aagggcagac tgggcttccc gattctcatt aatgaaatcg ccgctgccat tcttgtatct
     7561 tcggcatgac tttttaataa acatgatagc tcctccgctg cttcactcgc gtcttcccca
     7621 aactcaccta aaacagctgc agcaatatta cacaaagagc cttcctcttt taaggcctca
     7681 accaaaactg gtattgcatc ttttcccgat ttctttagct cacctatcgc ttgaacaatt
     7741 gtgatctcat ttgtattcgc taaattctga acagataacg acaatttatc accatttgaa
     7801 ttcataaaag agcccctctc ctcgttttaa aacaataact ctacataacc actatctgaa
     7861 acgataaaac aggcaccaac ttaggctccc tatacagacg accaccacta atgtatacca
     7921 gtcagcagtc aataaatgaa tgacatacaa acaaatgccg ctcaggccta atgccataaa
     7981 aaatgacttg taatattgag gcaatgaaag cttaatatcg tttcggtttg tatgggtaaa
     8041 agcaaaaagc cttattgtca tgaaccatat atatatccct aagccatata tataccaata
     8101 aactaaattc ccaactgcca taaaagtaat agagacacag tagagaatat acaaccagac
     8161 tgtattcgtc agctctagaa taatgatttt tttccaaagg gcaccgggga ataaatgaag
     8221 ggtgcctgat tgagaatgtc tgacaattcc tgaataatag gaacttaaca tgactgccga
     8281 gacgataaga aagaaaagaa gataaaacca ttctggatac atgaaaatga cgacataaaa
     8341 gacgccactg agcatgaccg tatgaatgct atgaaaaaat aaatattttt taaaaagcaa
     8401 cagttccaac cacagaaaag accaaatgcc atttagacct tgcaagcccc accaagtcgt
     8461 ttttggtttc tgtataattt gacctgaacc aaattgacgt tcttgaaatt cctcccagaa
     8521 ttcagcttct ttcaccaacg attccctcat ttctacctga cggctcgtaa aagcaattgt
     8581 cataaaagag actgtgatga tcccaataaa tacaaccaca tacaacggtg acaatgtatc
     8641 aaacactaat ccaacgccac taataaaacg ggcaatgctc tcccatatcc cagatgaatg
     8701 ttggagaaag aagaattgat aaagacatat ggagtaaatg cctaacatta gaagaaagac
     8761 tgaaacgtat acccttttca ttttcttcac tgttctggca caggagaccg acatcaacca
     8821 cacttcagcg ataaaaaaga gccctataaa aattatggat cggcctaata aattgatatg
     8881 ctcaccagac agaagcacaa ttaatacatc accgaatatg gctgagatga tccaaagcaa
     8941 cgccttccaa gtgacgctga aaaataaaac actatacaca acttttgaaa aagatgtggc
     9001 agtgccataa agccatataa tatctgccat ttgacttggt aatcgatttg aaaaaagtcc
     9061 aaatgccgta taaaggataa aaacacctgt aagtacccaa ccagcaatac tcatatccca
     9121 tgtcgtagat ctagaaacaa aacttacttg aaatccgatg gccccaacaa aaaggagcat
     9181 gatcaaaaaa ggcatttttt tttcctgacc ttgactgaca aaacgccttt ttgactgaag
     9241 ccataaaaaa gaaatgatat tattcatctg accattcccc cagaagacgt atcacttctt
     9301 ttctccattc cgcttgttct tcttcgaatt gaggaacata caaatcctgc atgagtttgc
     9361 cgtctctaat taatatcacc ctgtctgctg tctctaaaac aaactctaga ctatgagttg
     9421 atacaaatgc tgaacactct tgatcggttt tagtttttaa ccagttagag agccactgtt
     9481 ttgatgggat atcaaggccc acagtcggtt cgtctaatat atacagcaaa gcgtcttgaa
     9541 caatcgcccc cgccaggaca acccgctgct tttggcctct tgacagctga ccacacaatt
     9601 ggtttgcttt ctcctccaag tgcacttcct tcaatgcatg ataaaccctt tcttttacat
     9661 cttttttacc tggatgatat cctcttgccc taaactgaat atgttcagca gcggttaaag
     9721 cgggatacag atatggctga tcaggaataa gcgcgacttt tttttgaaca tttatatgtc
     9781 ctggaggaga accctcaatg aggatatctc ctttatccgg cttatagaga cctgtcaaac
     9841 atcgaattgt cgttgttttt ccagctccat ttggccccaa tagcgccacg atttctcctc
     9901 gttgaattga gaaagacaaa tgttcaaccc catcaccatt tcgatagcat ttgcttaaat
     9961 tttgtacttg catcaattgc atcaaatctt ctcctaatca ttagagtgaa gtatgctttg
    10021 gctgatcatg atgcatatgt ttctgaagct tgaactgcca cagcggcata cagacgatta
    10081 ctaaattatg aatgaaatga gctactaata cacaaataaa accaaatttg atgaagagaa
    10141 ctcccagaaa gcaaccgaat ataaatagat gcagccaacg tatccacctt gggtcatatc
    10201 cagttacttg gtgcatcacc gcccataaaa aggaagatac aataatggag atgaggatat
    10261 ttccactcat ccaccaaatg actggaatca ttaatagccg atagatgacc tcttctccaa
    10321 ttgaactttg tatgctcata ttcaatcctt gcctaaaggt aaaacctgat agaaagacag
    10381 ttcggttaga aagctcaggt gaaattcgta aataatgctt tttctccaat aagttaaaca
    10441 acagagaagt cactcctaaa ctaatgagcc ctgctcctat tccatagaaa atctgaacta
    10501 ttggttgttc aaacgttttc catccaaaat caccagcaag cgcatttcct gccaatgaac
    10561 atataaatac tacaaatcct gttaataatc ctgtaagaag tgtagacaaa atacctaata
    10621 aactgaccgt tttgacactc attcttgcat cataagcatt tacaattgtt aattgaatat
    10681 cttctttcag cgtcaatgac tggaatatta taatcaacaa acccagaaca agactgaaga
    10741 ttatgcttgt ttgcacatcc ataaatacaa ggatgagaat cgcaaggatc atcgctaaag
    10801 ctgaacccag cataccagat actccgaatg tcgattccac ttgttcatct cgaatgactt
    10861 tactcatttg atctgttagt atttcttgtt cagtaccaat ataagaaatt cggccgccct
    10921 gtaattcaac agtcaccttg agccgaatat ctcccgcttc cgctatgtac caataagtac
    10981 tgacctcgcg aaaatcctcc tcttttttac cagtaccagt catatttgct ctagaccaaa
    11041 gtccatcagg tgaagccatt aacctctgct tgagtgtctc tggagaaact tgttcaaact
    11101 tccccgaaag ggtttttttc ggaacatccg cataaaaaaa agtgatttct cgattggcat
    11161 tgacaccaac tacaaatgat tgattctggt gaacgaaacg gactctccat gattcgacca
    11221 acccaacatc atataaaacc tttctatttt tcttaagtat gcctaagtga tgaagtttat
    11281 ttactgtatc gtggtcatac caatataccg aataaaaatc ccagttctct acatctatcc
    11341 caacaaactc ttttataaat tgaatgctta tttcttttgc ctcatctttg cttaagagta
    11401 gtgaagcaat tgttgggggt ttgaatttaa taaataacag taatccaaca actgctaaaa
    11461 tactccagaa caccaatgat agactattca ttcctgaatc cctgccttga cttctttttg
    11521 aaaaggcaag tccggttcag atagctcaat tttccctata catttgcaat ttttagcttc
    11581 acattttaac tgaagcaaac gagcaggtga accaatgtca gccatgctat cttctaaaat
    11641 atgccctagc ggcaaatctt ctaattggca aggagttacg tatccatctg ctcttatata
    11701 ccaagcaaga tatcctggtg tacaaaaatc tgttgtgaac gaactctctt cgtgctccca
    11761 atcaattatg ttcaggcgat ctccccattt atgacgtgct tccctaagct gtatttgaac
    11821 catttcttca aaatcaatat ccaaagcctt aaagccttct gtcgcacgtc caacagataa
    11881 cgtttttcct gcacgaaaga taaaagcacc cgcattggca cattgctcca ccacatctga
    11941 tacttcatca gcattggact cattaatggt catagcgaca atcactggaa tgtttgcttc
    12001 tgataatttt ttaatggtat tcatactttc tttaaagccg ccttttctgc ctcttaattg
    12061 gtcatgtgta ttatccatac catcaatact aatctgtaca gaaacattgc ctaagtgact
    12121 aagtaattca acttcttcat ctcgccagtt caatccatta ctaaatacat tcacattggt
    12181 aaacaacgaa cttgcaacaa cgactaattc tttaaaccct ttgatcagct ttgcttcacc
    12241 cccggtcagc gtaatatcag caactccatg ggctgctaac ttttgcataa ccaatatcca
    12301 ttgttcacta gatagttcct caggatatgg tttacctgag ctggcatagc aaaacgaaca
    12361 gcttaaatta caagcatttg tcaactgcaa ggtacaacta ataggtaaat atgaatctag
    12421 cgaacccgaa acgtgtaaag gctgatctaa cagtccttcc gtccaagcct ccgtaaatgg
    12481 atgggcacta agctcttctt ttaattggtc agcactcatc tcttcttttt tcataatctc
    12541 ccaaatacgt gccgttttat gaagattttt gttttttgat aacagaaacg ccaactgtgc
    12601 tccacgtcca ctgagtctga aataaaacat actttttcta tcaatcatta cagcaccatg
    12661 aggctgtaaa tgaaccgcta actctggcaa atcaaaatct ttaacacgat catatgacat
    12721 ataaaatccc ccttaagaga aaataaggag tataagcaaa tacgctcaac tccctattct
    12781 caaatgttaa atagctctca tagcaggatg cggaagtgca caaacacgtg tcatagcaat
    12841 actcttcgag gcccaacagc ccatgcagcc agcagccttc acaatcgaag tacctcccgg
    12901 cttcataagt ccttttttac taacagattc ccattctttt tggtttcttt tcataagtaa
    12961 acctcctctc aatttttgca tagagtctat tgacatagct cccatgcgat acgataatac
    13021 cagattgcaa ttgtcgaagt aagggggatt ttgtatatta tcctaaaaat tacattaatt
    13081 agtataaata caatatttta ac
//
