LOCUS       c00002_gnlPro..        23249 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJLFBMDF_2.
ACCESSION   c00002_gnlPro..
VERSION     c00002_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 06:09:43
            Original ID  :: gnl|Prokka|KJLFBMDF_2
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 3394
            Orig. end    :: 26643
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..23249
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[13394:16643]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..23249
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..23249
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(119..1210)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:Periplasmic binding protein-like domain (Score:
                     107.3; E-value: 3.4e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_3"
                     /sec_met_domain="Peripla_BP_3 (E-value: 3.3e-33, bitscore:
                     107.3, seeds: 83, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNGKPKYFSLMEQLRSDIVSGVIRPGEKLPSENELSQKYSLSR
                     HTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMD
                     NVLSESGYSIILKNTANSRQKESRCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDK
                     FEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERH
                     KGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQV
                     MEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPE
                     EESKVERLIYPELIIRGSCRKIL"
     CDS             complement(1402..2289)
                     /locus_tag="ctg2_4"
                     /transl_table=11
                     /translation="MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSR
                     MAGVKNREGAGLLADGKKTDEDSSTENSEKKRRKKQRRSSKSKNKNHADEIRESFGISW
                     ENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRREEDLFGCIFLEHDIKRNF
                     TESHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEIITPKRKFLYKIFSVEQASSQS
                     PAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHG
                     ICHECYGIEKAEPK"
     CDS             complement(2286..6995)
                     /locus_tag="ctg2_5"
                     /transl_table=11
                     /translation="MKHNFKLKERLGALLLAMLFILQAILGLVPVCVTQAAPLTVETWD
                     SDKVVDYGYRFNMKFQPGITTYESFGCDNLDREAFSDNGKSERDTECVRVGADYKAGSA
                     GMRYNNVGKDGNGNIVDVRLILVGVDNAEPRYDLRTAESIVQNKGGATFAWKDNEAYPM
                     VGFSKNSIGVFIYSVGYAKVKFQFLKHGTEETLPISGHGTIRDIDAGQGVRIPSDSSLD
                     NAYVLKNNDYLTVDGNSVSSPLGSVEPDDPRGWLNLFYNTDNFTVEFCHQFRLDKWDKS
                     REDAIAKAGSQERWAEITRNKYLDPSGNSYCPNFKGQKYCKAYAYFDFTSYCFGDVEMK
                     KAPEKRVGEANCTWEQAAAASKEKPFGIRQGQEFQYMIWAEVTPNRLKSFVVQDILEDC
                     LAIEDASKISIVNDAGQTVTDWFDVAVEGQKVTCRAKAESLQDEAFTDNQTYTFTLKVR
                     QRPESEINISKYLAEDGYSILVPNHASMSYERTNGSGDTMDTETVWVKGVIPPELEVKK
                     NTSQYEWKTGDIIDYEILVSQTKQDVKAVNVVITDELPSCLQLLEGQYAVETSQGGENC
                     TLTGQGENGWKAECPSLKYGEMITIRFKCQASADSNGQEWENIVTATADNLINPETGEQ
                     ESRKDMAEVWPNSPQLEIDKTADKYEWQAGEQVAYRIVVNNVTAGTIAKDVTITDIGLP
                     QGLVLAGGTQSMEVLGVQQQVNYPVPDKKTGQAYEARPVDSQLNADENGFSFYCSYVPY
                     SQPVTIIFHCIAQEEANGHESVNAATVKAANTDERSDDAEVYVNSGEFWIEKSADHYEW
                     QVGEQVQYNVVVENKKAGTVARNVTVWDTGMPAGLALSSAEDVSVSGIPQNITQLTAGT
                     KDVLNQLNPEFYNETSEKPVNYEFLQEGSGWRLNISDLPANTPVMISFLCTVTEAANGM
                     ESINVANVQAQNAPVSQDDAEVYVNTAVLSIEKSFQNPYLAAGDGRAENEFRVGEQVNY
                     QVTVNNLQKGSIARNLVISDLSLPEGLALDGAEDAVTVSGVPAVIQNPVAGTDDAGNQL
                     NPENYKETVEKPVSCQVTRQGTGWIVTISDLPYQTPVTVNFRCTAQESVNGMEIVNTAQ
                     AYADNAQKVKDSSKIWVNSPVLKVEKTTDKPFYKYGDIITYRIVLTQEQTGCVARNVTL
                     QDVIDTQGVRLLKDSVILMDEKGNVADADVQINDDNTFLMSTGRTLVRDSRYSICDNDK
                     GGLFEQVMYNPLDCQEQKSMIVEYQAAVIDAALAGQKVHNTAVADSSEKIPATGETETE
                     VHSPILEIVKESDKKEYASGEKGYYKLTVRQLREDVTDQNIVIEDKLETQGASIVKDSI
                     FVKKNGIELKDAKIEADDTGFVIQTGASLSDMDKIEVCYEMVFKTESTEPEKIVNTAKA
                     RGDISPEITAQQEAYVKAKAEPTATPTPSATPKPTETPKPTETPKPTEVPKPTEQPKAT
                     PTPSVPGTCPKMTPVPTKAPLASYNGGNNGGTTSGSGGSSYANSGGYSGGYGSYQGGSM
                     AGSSKTGDVRPFKMMAVLGLIGMGLLTGGVVIYRRTVSGKRNIKGMPRK"
     CDS             complement(7198..7659)
                     /locus_tag="ctg2_6"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETEFPHQQEKRWKKVIDLS
                     TWHGRAVVIAAAAVIIILLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(7883..8761)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_7"
                     /sec_met_domain="CN_hydrolase (E-value: 1.6e-55, bitscore:
                     180.1, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTVEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(8863..9966)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_8"
                     /sec_met_domain="PAD_porph (E-value: 3.4e-128, bitscore:
                     419.3, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAF
                     VKVAEAIGESEKVYMLVSKAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEK
                     GAVCGVDWQFNAWGGDFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDG
                     EGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCA
                     FVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTRED
                     VDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRI
                     YPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(10001..11122)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_9"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.2e-14,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDHICDHIIFNS
                     TAQLKKFKDVCTRASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMYEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(11112..12392)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_10"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2.3e-43, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.1e-35,
                     bitscore: 114.8, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRTIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(12389..13249)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_11"
                     /sec_met_domain="Spermine_synth (E-value: 1.9e-53,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.8e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDDLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(13252..14709)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_12"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.5e-13, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 3.3e-126,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
     CDS             15933..17618
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_13"
                     /sec_met_domain="FTHFS (E-value: 2.6e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(17727..19151)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_14"
                     /sec_met_domain="Lyase_1 (E-value: 9.9e-95, bitscore:
                     309.4, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 5.3e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIISGQFHNEFIVDPIQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             19301..20236
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg2_15"
                     /sec_met_domain="LysR_substrate (E-value: 9e-33, bitscore:
                     105.3, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.2e-18, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIEAVEKVMDIENNLENFLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFEHYIYQKEQ
                     LLLAVPKNYSINTKLQEYQIPIEEIRNGQFRSSDIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELIFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(20311..21768)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_16"
                     /sec_met_domain="FGGY_C (E-value: 6.7e-38, bitscore: 122.3,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 5.5e-79, bitscore: 257.1,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEDSGKICNIVSKEYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRTKVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKEKLSEYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSEDVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENNVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARSLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
ORIGIN
        1 gcactcatct ccgtaaagat cttgtgaacc tgtacaaaac cagaacttat agtttcttcc
       61 tgttttcatg ataaaattcc tcctggattt atttttattt tttatttatt tcatttgttt
      121 acaatatttt tctgcatgat ccccgtatga tcagttccgg ataaatcaat ctttcaacct
      181 tactttcttc ttcaggaact ccgttgatct tctcaagtat aagctctgct gccatttctc
      241 ccagcttttc ctgcggatga gctatcgttg tgattccgct tcctcgctga gcatacagtg
      301 aattgtcata accggtaatg gaaatatcat ccggtatcct gactcccatt ttctccagtt
      361 cttccataac ctgaacagca atctgatcat tgtaacagac gattccatcc ggaagctgtc
      421 cgctctgtac catttctttt gccatcagtg caggttttac tttcctgtcc tctgtatgaa
      481 accagacaac atcatcagga tcataggcaa tccctgactc ctgtaaggcc ttcacatatc
      541 ccttgtggcg ctccagtccc tgcatatcgt ctgccttaaa gaaacccttg atctttttat
      601 gtcccagttc cagcagatat tttgttacaa gatagcctcc ctgtgcatca tccataagaa
      661 tatgaggttt atccctcatt tctgaataga ttccctgaat aaacacatac ggaatttcaa
      721 atttatccag attctgataa agatttctat gtttacagat catctcactt ttgcttggtt
      781 caatgatcag tccatcaata tctttcttca gaagttcctc cagacatctg gactctttct
      841 gtctgctgtt tgctgtattt ttcaggataa tactgtaacc gctttctgaa aggacattgt
      901 ccattccctg tatcagtctc ggaaaaatat aatcagaaat atatgtggtc actaccgcaa
      961 tattctttga attctttata tggcgcatat tctcggagca ataagtacct ctcccatgaa
     1021 atgcctccac atatccgtcc tgctccagga ttcccagtgc cttacgaacc gtatgtctgc
     1081 tcagggaata tttctgtgaa agctcatttt ctgaaggaag cttttctccc ggccggataa
     1141 ctcctgacac aatatcactt ctgagctgtt ccatcagtga gaaatatttc ggctttccat
     1201 tatctgtcat gtcttcttcc ctcctgtatt taggatacaa cttgtacgca cgtacgaaca
     1261 agttgttttt tatgcataaa ttatacaaaa tatcgagaga tttttcatta gttttttcca
     1321 aaacacctcg agggataatg atatgtgaac agtaacagtt catcctttac gaaagttacc
     1381 aatatccgat tgatttcaac atcacttcgg ctcagctttt tctataccat aacattcatg
     1441 gcaaatccca tgtaccgcca tacgtatttc tttatccaga cgtgaattac aggtgatcag
     1501 agtcaccatt ctctcccttt catcaggctc tactcctgtg tcatacatgg aattattttt
     1561 caatatagat aattgtctcc tgtatgcagg actggataac ttgtatccat attcaaatgc
     1621 cgggctttgg gaagatgcct gttccacaga aaaaattttg tacagaaact ttctttttgg
     1681 tgttatgatc tcaatttcag gacatttttt cagaaattca ggctgttcat aacggttcag
     1741 atttgcgaac atcatattac cttctatatt gtgcccgtaa agaatactgt gggattctgt
     1801 aaagttcctt tttatgtcat gttccagaaa aatacagcca aacagatctt cctctctcct
     1861 gaaattatgt ttcaggtaat attcatcatc tgccgcctga actacaggat aagaaatatc
     1921 ggctcccgga acagtaatcc aggcaactgt ctgagagttg atttttctta aattttccca
     1981 ggaaatcccg aaggattccc tgatttcatc tgcatggttt ttgttttttg atttagaaga
     2041 tcttctctgt tttttcctgc gttttttttc actgttttct gtactgctgt cttcatcagt
     2101 ttttttgcca tctgccaata atccggcacc ttctctgttc ttcacccctg ccattcggga
     2161 aagctctgca tattcctgcc ttgctgcaag attctgttca taacttttta tatagaagcc
     2221 ggcacaatat ataagaagcc caattgctgc tatgatcata cttactgcaa atgttctgag
     2281 ttttttcatt tccgcggcat accctttata tttcttttcc cggaaacagt tcttctgtag
     2341 atcaccacac ctcctgtcag cagtcccatt ccgataagtc caagaacagc catcatttta
     2401 aacggtctga catctcctgt tttagaactt cctgccatgg aaccaccctg atagcttccg
     2461 tatccaccgg aatatccacc cgaatttgcg taactgctgc ctccgcttcc ggaagttgtg
     2521 cctccattat ttccaccatt gtaagatgcc aacggtgctt tcgtcggtac aggagtcatt
     2581 ttcgggcagg ttcccggtac agatggtgtt ggtgtggctt ttggctgctc cgtcggtttc
     2641 ggtacttctg ttggttttgg tgtctctgtc ggctttggtg tttctgttgg tttcggtgtt
     2701 gcagacggtg ttggtgtagc agtcggttct gcttttgctt tcacatatgc ctcctgctgt
     2761 gcagtaattt ccggtgaaat atcacctctt gctttcgctg tgtttacaat tttttcaggc
     2821 tctgtgcttt ctgttttaaa taccatttca tagcagactt caattttatc catatctgac
     2881 aacgatgctc ctgtctgaat tacaaatcct gtatcatctg cctctatttt ggcatctttc
     2941 agttctatac cgtttttctt cacaaaaatg ctgtctttta caatggaagc cccttgggtt
     3001 tccagtttat cttcgataac aatattctga tctgtgacat cctcacgcag ttgtcttact
     3061 gtcagtttat agtatccttt ctcaccggac gcatactctt tcttatctga ttccttcaca
     3121 atttccagaa tcggactgtg tacctctgtc tctgtttccc cggttgcagg tatcttttca
     3181 ctgctgtctg caactgcagt attgtgcact ttctgtcctg ccagggctgc atcaatcacc
     3241 gctgcctgat attccacgat catacttttc tgttcctgac agtccagagg attatacatt
     3301 acctgctcaa aaagaccgcc tttatcatta tcacagatac tatatctgct atccctgacc
     3361 agtgtcctgc ctgttgacat caggaaagta ttatcatcat tgatctgtac atcagcatct
     3421 gccacatttc ctttctcatc catcagaatc accgaatcct tcagaagacg tactccctga
     3481 gtatcgatca catcctgcag agtaacatta cgcgccacac atccggtctg ctcctgtgtc
     3541 aggacaatgc ggtatgtaat aatatcacca tatttgtaaa atggtttgtc cgtcgtcttc
     3601 tctactttta gaacaggcga gttcacccag atttttgagg agtcctttac tttctgtgca
     3661 ttatctgcat atgcctgtgc tgtatttaca atctccatcc catttacgct ttcctgcgca
     3721 gtacagcgga aattaacagt cacaggtgtc tgatacggaa gatctgaaat cgtcacgatc
     3781 caaccagttc cctgacgtgt aacctgacag ctgactggtt tttccactgt ttctttataa
     3841 ttttccggat tcagctgatt tcctgcatca tcagttcctg ccaccggatt ctgaataaca
     3901 gccggaacac cgcttacagt aacagcatct tcagctccgt ccagagccag cccttcagga
     3961 agggaaagat cactgatcac aagatttctt gcgatagatc ccttctgaag attattaacc
     4021 gtaacctgat aattcacctg ttctcctacc cgaaattcat tttccgcacg tccgtccccg
     4081 gctgccagat atggattctg aaaacttttc tcaatagaaa gaactgctgt atttacatac
     4141 acttctgcgt catcctgtga aacaggggca ttctgcgcct gcacattggc aacattaatg
     4201 ctttccattc catttgccgc ttccgtaact gtgcaaagga aagaaatcat aaccggagta
     4261 tttgccggaa gatctgagat gttcagtctc catccgcttc cctcctgaag aaattcataa
     4321 ttcaccggtt tctctgatgt ctcattataa aattccggat tgagctggtt caaaacatct
     4381 ttggtccctg ctgtcagctg cgtaatattc tgtgggattc cgcttaccga tacatcctct
     4441 gccgatgaaa gcgcaagtcc tgccggcata ccggtatccc agacagttac gttccgggcc
     4501 actgtacctg cttttttatt ctccaccacc acattgtact gtacctgttc tccgacctgc
     4561 cattcataat gatctgcaga tttctcaatc cagaattctc ctgaatttac atacacttct
     4621 gcatcatcag atctctcatc tgtattagca gcttttacag ttgctgcatt tacgctttcg
     4681 tgtccatttg cctcttcctg tgcgatacaa tggaaaataa tcgttacagg ctgactgtat
     4741 ggtacataag aacaataaaa ggaaaatccg ttctcatctg cattcaactg agaatccaca
     4801 ggtctcgctt catatgcctg tcctgttttc ttatccggta cgggatagtt tacctgttgc
     4861 tgaactccca gtacttccat gctctgtgtg ccacctgcca gaaccagtcc ctgcggcaga
     4921 ccaatatcag taatagttac atcttttgca attgttcctg ccgttacatt attcaccaca
     4981 atccggtaag ctacctgctc tcctgcctgc cattcatatt tgtctgctgt tttatcaatt
     5041 tcaagctgtg gactgttcgg ccatacttct gccatatcct ttctggattc ctgttctcct
     5101 gtctcaggat tgatcagatt atccgctgtt gcagtcacaa tattttccca ttcctgtcca
     5161 ttggaatccg cagatgcctg acatttaaaa cggattgtga tcatctcccc atacttcagg
     5221 gacggacact ctgctttcca tccattttct ccctgtccgg taagcgtaca gttctcacct
     5281 ccctgacttg tctctacagc atactgccct tccagaagct gcagacatga tggaagctcg
     5341 tctgtaataa caacatttac tgcttttaca tcctgttttg tctgagaaac cagaatctca
     5401 taatctatga tatctcccgt tttccattca tactgagaag tatttttctt tacttccagt
     5461 tccggtggaa tcacaccctt tacccacact gtttccgtat ccattgtatc tccgcttccg
     5521 tttgtacgtt cataactcat ggatgcatgg tttggtacaa gaatactgta tccatcctct
     5581 gcaaggtatt ttgaaatgtt aatttctgat tccggtctct ggcgtacttt taaagtaaat
     5641 gtgtaagtct gattatctgt aaatgcttca tcctgaaggc tctctgcttt ggccctgcag
     5701 gtcactttct gtccttcaac agcaacatca aaccagtctg tcactgtctg ccctgcatca
     5761 ttcacaatac tgatttttga tgcatcctct atagcaagac aatcctcaag tatatcctgt
     5821 accacaaagg atttcagtct attgggtgtc acctccgccc agatcatata ctgaaattcc
     5881 tgtccctgac gaatgccaaa aggtttttct tttgatgcgg cagctgcctg ttcccatgta
     5941 cagtttgcct ctcccacacg tttctcaggc gcttttttca tctcaacatc accgaaacaa
     6001 taggatgtaa aatcaaaata tgcatatgct ttgcagtatt tctgtccttt aaagttcgga
     6061 caataactgt tgcctgatgg atccagatat ttatttcttg taatctctgc ccatctttcc
     6121 tgagaaccgg cttttgcaat ggcatcttca cggcttttat cccatttatc cagtctgaac
     6181 tgatgacaga attctaccgt aaaattatct gtattataaa aaagattcag ccatcctctc
     6241 ggatcatccg gctcaacgga accaaggggt gagcttacag aattcccatc taccgtcaga
     6301 taatcattgt ttttcagaac atatgcatta tccagactgc tgtctgacgg aatacggact
     6361 ccctgtcccg catcaatatc acgtatggtt ccatgtccac tgatcggcag tgtttcttct
     6421 gttccatgct tcagaaactg aaatttaacc tttgcgtatc ctacagaata aataaataca
     6481 ccgatactgt ttttggaaaa gccaaccatt ggataagctt cattatcttt ccatgcaaac
     6541 gtagctccgc ctttattctg aacaatcgat tctgcagtgc gcagatcata acggggttct
     6601 gcattgtcta ctcccacaag aatgagtctg acatcaacaa tatttccatt tccatctttt
     6661 cctacattgt tataacgcat ccctgcgctt ccggctttat agtccgctcc tacacgaacg
     6721 cactctgtat cacgttcgct ttttccattg tctgaaaaag cttccctgtc cagattatca
     6781 cacccaaaag attcatatgt ggtaattccg ggctgaaact tcatgttaaa gcgataacca
     6841 taatctacca ccttgtcact gtcccatgtt tctacagtta acggtgccgc ctgagttacg
     6901 cagacaggca caagccccag aattgcctgc agaataaaaa gcattgcaag cagcaaagct
     6961 ccaaggcgtt ctttcagttt gaaattgtgt ttcattttcc gtctcctttc cgaacaaaaa
     7021 atataaaaat gaatgtggga tttttccctg cacctggcag gattaaagaa tagaaataag
     7081 ttgagattgt atgattataa atattcaagg ggaattaata tcgtgaaaca agaacgttta
     7141 cacttaagat tttaagattc tgcgcagggt tccttttctg aaaccctgca tagattttca
     7201 ttgatcattt cttttcttca gccatgaaag aaaataaaga ataattgcaa gaattataaa
     7261 aaacggaatc gcaactccga ttatcagtat cagtaaaata attataacag ccgctgctgc
     7321 aataacaaca gccctgccat gccaggtaga aagatcgatt acttttttcc atcttttctc
     7381 ctgctgatga ggaaactctg tctcattgcc ataactgctt ccgtaagaag aatactctcc
     7441 gtaatcttcc tgtgtacttc catcatctgt atcgatcaga gtttttgcta tcagatgcgg
     7501 gtctcccagt tcctgcagta cttcctgctc tgaacgtccg ccacgtacct gagactgtat
     7561 ataatcttca taatacctga tatgtgctgc tgctttgccc tcctgcatct gaccggcaag
     7621 ctggcttctc aggatttcca aaaattcttt tctgttcatc ttttacactc cattttgcca
     7681 gaaatacata tcaaaacttt cctgctccgt tatcagtaac gttcgtactt ttattttacc
     7741 atatatacta caggtagcaa ctaatataat cataaacttt ttatgaaatt cttataaact
     7801 cagttactgt tcactccgtt ctcagtaact gagccaaaat tcattccaga ttgcctgtgg
     7861 caatggaatt ttggcttgta tgtcatttcc cgacaatttt tgcatacatc tccggtctgc
     7921 ggtctctgaa aagtccccag ttcagtctgt ctgcctttaa tgcatccaaa tcaaaagtgc
     7981 ttacaagcac cccctcttcc cctccgggca gttctgcgca gagagcacct gtgttatctg
     8041 taataaaaga ggaaccgtaa aaattaagag cagatttctg cattccgttt tccggacatg
     8101 gctctactgt ttcctcaccg attctgttgg cagcgatcac agggatcaga ttggaggcag
     8161 cgtgtccctg catacatctt ctccagtgtt ccatgctgtc acattccagg atgggctcac
     8221 ttccgatggc agtgggataa aagagaagct ctgctccctg caacgccata catcttgctg
     8281 tttccgggaa ccactgatcc cagcagattc caactccgat ggttccaaat ctggtatcaa
     8341 aaaccttaaa gccggtgtct cccggtgtga aatagaattt ttcctgataa taatgatcat
     8401 ccggaatatg tgtttttcga taaatgccga gattcttccc atctgcatcc agaaccgcaa
     8461 cgctgttata agtattattg acctcttttt cataaaagct gaccgggatc acaatcccca
     8521 gctctgccgc tactctgctg aaatgacgca ctgcagggtt ttcctctaca gtctgcgcat
     8581 attcataata ctcatatctg cgctcctggc agaaataggg ccgttcaaaa agctccggaa
     8641 gaagaacaat ctcagctccc tttgctgctg cctgacgcac cagttcctct gcatgggcaa
     8701 tatttttctc cacactttta ctgcatttca tctgaactgc tgccactgtt acatttctca
     8761 tcctgtctgt tcctcctgct cctgtttaca taagtaagtt ttttcataac tttcaggtaa
     8821 taaccctcaa acacatgact ctcaaagttt tctgcatcag ggtcagatat tttttccggg
     8881 aatctgctgg gtgatacagt gaatatttcc accgccaaca atgatggctc tggcatcaat
     8941 gggataaatc cttctttcag gaaaacactt ctgcagaatc tccactgccc ttttgtcatt
     9001 ttcatcccca aattgtggaa ggatgatccc tccattggaa atatagaaat tcacgtaact
     9061 ggcagccatc cgttctcctg cttcccgttc atcttctccc tcttcaaaca caaagccatc
     9121 cacatcttcc cgggtaaggc agaccggttt ctgaggaatc ggaagcttat gaatcttaaa
     9181 ttttctgcct tttgcatctg tttcctgttc cagcaccttc agatcagcca gagacatggc
     9241 atactgcgga tctgtctcat cctctgtcca tgcaagcaca acctctccgg gccttacaaa
     9301 agcgcacacg ttatccacat gctcattggt ttcatcctga tagattccac atggaagcca
     9361 gataatcttg tggacaccga gccagtactt caactgttcc tctatctgtt ccctgctcat
     9421 ctgaggattg cgtccctgac tcagaagaca ggcctctgta acgatcagag tcccctctcc
     9481 gtcagaatgg atggaaccgc cctccagcac aaaaggtctg gcatccagac atggacaacc
     9541 aagagtcctg cagataaagg cagccaccct gtcgtccttc tcccagttcc ggtaaagtcc
     9601 atcaaagtct cctccccagg cattaaactg ccagtcaact ccacagaccg cccctttctc
     9661 atccagaacc atggttgctc ccacatctct cgcccaggca tcatctgtct cgcattccag
     9721 caaagtcaca ccggaaacat ttccaagctg attctttgca ttctccatct gagctttgga
     9781 aaccagcata tacacctttt cgctctctcc aatagcctct gcaactttca caaatgcttt
     9841 ctgtgcttcc cttgccccat aattccagga accgggacgt tccggccaga tcatcacaca
     9901 tccctcatga ggctcaaatt ctccgggcat acgatatttt gttctgttct tctctgtaac
     9961 ttccatgtct gtctcctttt ctttgatagc ccggcagata tcaggaaagc cggctcttaa
    10021 agtcttcgta cccgaaatgt ctgataacct cacactctcc gtcctcatac ataaccgcaa
    10081 tatccggcag cggcataccg ttaaatgtat tattcttcac catagaataa atcgccatat
    10141 ccataaaata cagcttgtcc ccgatccgga tctctctgtc aaaggaataa tctccgatta
    10201 catctcctgc caggcaggtg caggaagata agcggtaggt atatgccttc tcccctgctt
    10261 ccccgctgtc cttaagaggc ggacgatagg gcatctccag cacatccggc atatggcagg
    10321 ctgcagaagc atccaaaatc agcgttctga tctcattttc cacaatgtcc ataacctctg
    10381 tcaccagata tccggcattc agggcaacag cctccccggg ctccagataa atatccagat
    10441 cataggtttc cttcatatgc tgaatacatt tttccaggag ctttacatca taatcctctc
    10501 tggtaatatg atgtccgccg cccatattca gccaggaaac ctcagacaga aattctccaa
    10561 acttctcctc taccgcctgc aatgttttct ccagatcatc cgcattctgt tcgcagagag
    10621 tatgaaaatg cagtccgtcg atccatttca gacattcccc gtcaaagttc tctctggtaa
    10681 cccccagcct ggaacccggc gcacagggat catagatcgc atgatccccc tgagtggagc
    10741 attccggatt aatacggagt cccagactgg ctctggtaca cacatcttta aatttcttca
    10801 gctgtgctgt ggaattaaag ataatatggt cacagatatg atccagttcc tctatatctt
    10861 ctgtacggta agcaggggaa aaaacatgat tctctttccc catctcttca tatccaagcc
    10921 ttgcctcaaa cagaccgctg gcagtggtac ctgccagata ttttccaatc atgggataca
    10981 gggcaaagcc ggaaaacgct ttctgcgcca gaaggatctt acacccggta tcctcctgga
    11041 cttttttcaa aatctccaga ttctcccgca tcttcttctc atcgatcaca taacagggag
    11101 tttgcagttg atcaatcttc attggctttc cagaccttta ccagttcagg atcttcgcag
    11161 actttccatg gaagtcccca tttgttcagt gcttccatat atggatccgg atcaaattct
    11221 tccacattaa atacacccgg cttcttccac tgtccggtca ctaccatcat ggaaccgatc
    11281 atggccggaa cacctgttgt ataggagatt gcctgggatt ccacctcttt atagcattcc
    11341 tgatgatcac atacattata aatatagata cttttctctt ttccgtcctt aacacctgtg
    11401 aaaatacagc cgatatttgt tttacccact gttctcggtc ccagagatgc tggatccggc
    11461 agaagagctt tcaaaaactg gatcggcacg atctcctgtc cgttaaattc cacaggtgcg
    11521 gtggaaagca ttcctacatt ttccagacat ttcatatgtg tcagatagct ctgtccgaat
    11581 gtcataaaga aacggatcct ctgtactccc ggaatatttt ttgccagtga ttcaatctct
    11641 tcatgatgaa gaagatacat atccttcttt cctacctcag gaaaatcgta gacagattta
    11701 aattccatag gctctgtttc tacccaatgt ccgtcttccc agtaggaacc atttgcggaa
    11761 acctctcgaa gattgatctc cgggttaaag tttgtggcaa aaggatatcc atgatcaccg
    11821 ccattacagt ccagaatatc aatggtatgg atttcatcaa aataatgctt cagggcataa
    11881 gcactgaata cactggtaac acccggatca aaaccggttc ccagaagagc agtcagtcct
    11941 gcttccttaa atttctcatc ataagcccac tgccaggaat aatcgaaata tgcagtaaag
    12001 cctttttctt tacatctctt ttcgtagatt gtacgccatg tgggatcttc tgtatcctct
    12061 gcttcataat tggcagtatc aatataatcc gcaccggctt ccagacatgc atccatgatg
    12121 gtaagatcct gatatggaag tgccacattc aggacagcat ccggcttata ggctctgatc
    12181 aattctgcga cctctgctgc attatccgca tctacctttg ctgtctcaat ttttgtcttc
    12241 gttgtacttt caatcttctc tttgagtgca tcgcattttt cctttgtcct gcttgcgatc
    12301 ataatctctg taaaaacatc gctgttctga cagcatttgc gaattgccac tgaagctacc
    12361 ccaccacatc cgattaccaa taatctgctc ataaactgtt ttcctcctct tccagtaaat
    12421 cttctacata ttttggaagc ataaatgctc ctctgtgaag gtttgttgta taataccatg
    12481 tttctatatt aagatcatca aacctctccg gcctgaaatc ttccagtgga tgatatttct
    12541 ttgatgcaaa tccaaaaagc cagtatcccg agggacaggt agggatatgt gcctgataaa
    12601 ccctgctcac cggaaatgac cggaaaacct ttctgtgcat ctttctgcat tccacctcat
    12661 cctcatcata aaaaggactt ccatgctgat aaaccatgat tccgtcatct ctgagagcct
    12721 tataacagct tccgtagaat tcctttgtaa aaagtccctc tgtatgtccc agcggatctg
    12781 tggaatcatt gatgatcagg tcatatctgg cctttttatt ccgcaggaac cgaaggccgt
    12841 cttcataata aatgttgact ctctcatcct tcagtccctg ggcaatatcc ggaaacatct
    12901 ccgcacatac atccacaaac attttatcgg attccaccac atcaatgctc tcaatctgtg
    12961 gataatggat cagttctctg gcaactccac cgtcaccgcc gccgatgatc agaacatttt
    13021 ttacattggg atgtactgtc attggcacat gcgtgaccat ttcatcataa ataaattcat
    13081 ctttatcaga gaatacgatc tcaccgtcca gagccacaaa tcttccaaat tcttcagact
    13141 caaacacatc gattctctga aattcacttt cccctgaaaa taactgtcgg ttaatccgga
    13201 cagaaagctt tacatttcct gtatggaact cggaatacca taattccatg atcagatacc
    13261 ccctttcagg acctgaagat gttctacctt cggatcctcc attccctgca tggaacagcc
    13321 tttgtctctt gcataaagaa tgtattctac aatttcctgt gtcaccattt ctccaggagc
    13381 aagaatcggg attcccggag gataacacat aacaaattca ccgctgatcc tgcctgccgc
    13441 ctgttccatg ggcagagatt ctttctccgc ataaaatgcc tgctgtggag acgccaccac
    13501 tgcaggtgcg atatattccc cggaaagcat acctgtgctg tccttcttat acagacgttc
    13561 aatatcagcc aacgccccta ccagtctctc aatatcctga agcctgtctc caatggaaat
    13621 gtaagccaga atattacaga tatctccaaa ctcgatctga atatcatatt catctctgag
    13681 aagatcataa acttcaatac ctgccagccc atttcccagt gtataaatgg agagttttgt
    13741 aacatcaaaa tcaaaaacac tggttccatt gatcagatcc ataccatatg cataatagcc
    13801 gccgatctca ttgatctcct ctctggcata ctgcgccatc cctgcaacct tttcaaagga
    13861 ttcctctccc ctgagtgcca gatttcttct ggagatatcc agactggaca acagaagata
    13921 agaagcgctt gtggtctgag tcagattgat gatctggcgc actttctctg cattcatact
    13981 cttattcaaa agcagcagcg aactctgtgt cagacttccg ccggatttgt gcatggaaac
    14041 tgccgccatg tcagcacctg ccgccattcc ggatacagga aggtttctgc cgaaataaag
    14101 atgggttcca tgagcctcat ctgccagcac cttcattcct cttgcatgag ccttctttac
    14161 gatagtccgc agatccgaac agattccata ataggtaggg ttatttacaa gaactgccac
    14221 cgcatccgga ttctcatcca tagccttctc cacctgactg acttccatgc caagggaaat
    14281 gcccagctgc gcattcacct ccgggtttac ataaaccgga attgcaccgc acagtaccag
    14341 ggcattgatg gcacttttat gtacatttcg tggcagaatg atcttatccc ctgccttgca
    14401 gacagacagg atcatgctct gcactgcaga tgtggttcct cctaccataa gaaatgcatg
    14461 cgctgcgcca aaagcatctg ctgcaagctc ctccgcttct ctgatcaccg aaaccgggtg
    14521 gcagagattg tccagcggct tcatagaatt aacatccagc cccacacatt tctctcccag
    14581 caactgtgca agctctggat ttcctcttcc tcttttatgt cccggcacat caaaaggaac
    14641 cactctcttc tttcggaaac gttccagtgc ttcatatatg ggcgcatgct gttgtctttc
    14701 ataatccatt tgacatgttc ctcttttcct gtcgtcatgt accggcaaat acagttctat
    14761 cattcagcaa ttgtatactg cctcaaaccg gcacaatgat tcaattattt ctctatatat
    14821 ttgctatatc tgcacaaaaa aagaagcaga taagttcatt caccatctgc ttctctcatg
    14881 atctatagaa tttctcaggc tctgtctctt tatatactga ccggatttcc cgtataaatc
    14941 cgtctgtatc ctgtgcctgt tcccgtattc tgaaatattc atgactgctg tcgtcttcaa
    15001 tcgctggcaa atatatgcta tgctcttatt gaccgtttca caagatgatg tgtgcttacg
    15061 cactgattat tataaagtaa tcaacttata aaatttgagc ttctaactca atcaataatg
    15121 tggtgtctcc cacccggcaa ctgccccgcc tgtccgtatg gcttaacatt cagaaactgt
    15181 ctctgaatgt gagcaaatat ttgcatgaaa acgatagtgt cttttcatac taaagatgag
    15241 aataacatat cttctgaact gttgtcaatt ccattttcca tattttgcac tagagcgtgt
    15301 ctgaaaaagg ctttctgcaa gatgtgcgtc acaatttgtg gtatattttg cccggatgag
    15361 ggcgccgtag cgggctacgg caactgaatt cgggtgaaat atcccgcaaa gtggggcgtg
    15421 cagattgcgg gaatgatttt tcagacacgc tctagcttta cccgcttttt atattttctt
    15481 catttatcag ggaaaactgt gtttattttt taacaatttc ttcccttgag aaaacgtatt
    15541 ttctttcatt accagggatt acgattctct tctcttatca atttgcacaa cttttatcca
    15601 gtttactcac attttttgac gtttcaacaa aaatttcttg acattttttt ctcaaaatga
    15661 tatattgtat tcatcaattg aaagaacctt cgagtactga cggaaagagt ggagtgcaaa
    15721 ccacgtggag tcggaggttt gtgggagccg accgtctggg cagtatttga agtattcaga
    15781 tactggcctt tttttataat ttccggagca gaaatcagga atgtcagaca gaccggccga
    15841 tacttctttc aattaataat tgttgctgat cgcggagtga acagcaacag aagtttttca
    15901 tgttatgcgg aaacgaaagg agaaaaacaa ttatgggatt caaatcagac attgaaattg
    15961 cacaggaatg cgagatgctt ccaattactc agatcgcaga gaaagcaggt attgacgaca
    16021 aatatctgga gcagtacgga aaatacaaag caaaaatcga ctacaatctt ctgaaagaaa
    16081 gtgataagaa ggatggaaaa ttaatcctcg ttacagctat caacccaact ccagcaggag
    16141 aaggtaaaac tactactact gtaggtcttg cagatggtat gcagagactt ggcaagagtg
    16201 ttatggtagc tcttcgtgag ccatccttag gaccggtatt cggtgtaaaa ggtggtgcag
    16261 caggcggcgg atacgcacag gttgttccga tggaagacat caaccttcac ttcacaggtg
    16321 acttccatgc aatcggcgca gctaacaact tacttgcagc catgatcgac aaccacatct
    16381 tccagggcaa tgcattaaac atcgacccac gtaagatcac atggagaaga tgtgtagata
    16441 tgaacgaccg tcagcttcgt aacgtagtag atggtcttgg cggaaagaca aacggtatgc
    16501 ctcgtgaaga cggatacgac atcacagttg catctgaaat catggcagtt ctctgtcttg
    16561 caagcgacat caaagacctg aaagaaagat tatccaagat catcatcgga tatacatacg
    16621 gaaaagtttc cgagcagaaa cctgtaacag caggtgacct tcacgcagaa ggcgctatga
    16681 cagccctgtt aaaagatgct ctgaaaccaa accttgtaca gactctggaa cacgttcctg
    16741 caatcgtaca tggtggacca ttcgcaaaca tcgctcatgg atgtaactct gtaacagcta
    16801 caaagatggc tatgaagctt gctgattatg caatcacaga agctggtttc ggtgctgacc
    16861 ttggtgctga gaaattcctt gatatcaaat gccgtatggc tggtttaaaa ccaagcgcag
    16921 ttgtaatcgt agctacagta cgtgccctga aatacaacgg cggcgttgct aaagctgacc
    16981 ttaacaatga aaacctggaa gctcttgaaa aaggtatccc gaacctgtta aaacacgttt
    17041 ccaacatcaa aaacgtatac aaacttccat gtgttgttgc tatcaacgca ttccctacag
    17101 atacaaaagc agagcttgac tttgtagaag ctaaatgtaa agaactgggc gttaacgttg
    17161 ctctttctga agtatgggca aaaggcggcg aaggcggaat caaacttgca gaagaagtta
    17221 tccgtcttgt agaagaacca aacgacttct cctatgcata tgaactggaa ggttctatcg
    17281 aagacaagct gaaccagatc gttcagaaag tttatggcgg taagaaagta gttctgacag
    17341 ctaacgctca gaaacaggct aaacagttag aagctcttgg ctttggcaac tgcccgatct
    17401 gtgtagctaa gacacagtac agcttaacag atgaccagac taaactgggt gctcctacag
    17461 acttcgaagt tacagtacgt aacctgaaga tttccgctgg tgcaggattc atcgtagctc
    17521 ttacaggtga gatcatgaca atgccaggtc ttcctaaagt tccggctgct gaaagaatcg
    17581 atgtagacga gacaggtaag atcacaggtc tgttctaatc cggttgaaat cagtcgaata
    17641 attcaaaaat ataaaaatca tatttatata tgatatgtgt ccagacgatt ttacaggcgg
    17701 gaagattttc ccgcctgttt ttttctttat ttttttataa gataatcttt tccggaaata
    17761 ccaggttccg tcatatggat cggatccaga atgcgattaa gttcatcctc gtccataagc
    17821 ttttctttca gaatcagact tcttacagat tcgcctgtct taattgcctt ttttgcaata
    17881 tccgcagcct tctgatatcc aagatggggg ctgattgcag tgataatacc tacactgttt
    17941 tctaccagat aacggcatct ttcttcattt gccgtaattc ctacaataca attatctacc
    18001 aatgtctgga ctgcatagcc aagagtatcg atagactgaa acatgcaata gaaaataatc
    18061 ggctcaaacg catttaattc cagctgacca gcctctgcag ccatggtaat ggtaacatca
    18121 ttaccaataa tattaaaagc aacctgattc actacttcag gaataaccgg attaacttta
    18181 cctggcataa tagaggaacc attctgtttt gccggaagat taatctcccc aaaaccagta
    18241 cgtggaccgg aggacatcag acggagatca tttgacattt tggaaagagt taccgcacat
    18301 gctttcacag caccggaaac ggctacaaat ggatccagat tctgagtgga atcaatcaga
    18361 tcaaaagcct gtataaagtc cattcccgat atttcagtga gatttggaac aattcttctc
    18421 agatagccct catctgcatt aattcctgtt ccaatagcag tacctcccat attaagagtc
    18481 cgcatttcat ccattgcttt atccattctg tggatatcac gcatgattgc taccgaatat
    18541 gccttaaatt cctgtcccag acgaattggt actgcatcct gcatctgtgt acgccccatt
    18601 tttattatgt gatcaaactc tgtagctttt tcattaagag catcatagag gcgaagaagc
    18661 tgttttttca gattctgcaa caaacgaaga gaagtcattt taccggcagt aggaataacg
    18721 tcattggtag actgtccaca attcacatca tcgttaggat ttataattgt ataatcgccc
    18781 ttttttcctc ccagtatctc aatcgcgcga tttgcaatta cttcattggc attcatattt
    18841 aaagatgtgc ctgcacctcc ctgaatagga tccacaataa attcattgtg gaattgtcct
    18901 gaaataattt catcacatgc ctggacaatg gcctgggctt ttttcttctc aagaagcccc
    18961 acttcacaat tagttatcgc tgctgctttt tttatgtatg caagactgtt aataatttcc
    19021 ggatgcatat tcaaccccgt aatgtggaag ttttcggccg cacgtaagga ttgtactcca
    19081 taatatacat cttccggaat atcctttaca ccaatagaat ctctttctac acgatagtct
    19141 gtttttttca tagtggttct ccctcccatg tatttgccct tattatatat ctctgctata
    19201 atataatcaa atacatatat ttttataaaa tatatagtgt ttaaattatg ttactatgaa
    19261 cagagtgaac agtaactaaa ttatatattg gagggatcat atgtttcagg gaatggaata
    19321 tatttatgaa gtatacaagg aaaaaagctt ttccaaagct gctgctgccc ttttcatttc
    19381 gcagccttct ttaagtgcaa atgtaaaacg tgtggaaaac cgcattggtt atcctatttt
    19441 tgatcgaagt accaaacctt tgcagttaac cgaagttgga aaacattata tagaggctgt
    19501 tgaaaaagtc atggatattg aaaataatct tgaaaatttc ctattagatc ttggaaatct
    19561 caaaacagga actctcaatg taggtggcag taacttcttt tcttcatgga ttctgcctcc
    19621 ccttattgct gatttttccc aaaaatttcc acatgttcaa atttctcttg tagaagaaag
    19681 tacagcaaag ctatcccagt ttctccaggc cggaaagtta gatctggtga tcgataactg
    19741 tattctggat aaccagatct ttgaacatta tatctaccag aaagaacaac ttcttcttgc
    19801 agttcccaaa aattattcaa tcaataccaa actgcaggaa tatcagattc ctattgagga
    19861 aatccggaac gggcagttcc gctcttctga tattccttct gttccattaa acaaatttga
    19921 gaacgaacca tttattattc ttcgttcaga taacgatacc ggtaagcgtg cacttaccat
    19981 ttgtcaggaa aatcactttt cgccttctgt agtatttcgt ctggatcagc agatgactgc
    20041 ctataatatt gcatgtttgg gaatgggtat cactttcatc ggggatcttc tgctctccag
    20101 agttccaaca aattcagaac ttatttttta taagctgccc ggtcagagca gtaaacgcac
    20161 tgtatttttt tactggaaga aaggccgcta tatcagcaga gccatggaag aattcctgaa
    20221 gctgcccttt tcctgatatg tcatacatat caaaacgggg ttattgtact aaatgagtac
    20281 aacaacccca gttatcaagc agatattcga ttagaacagt ggcttcatag ccggatacag
    20341 agttctgaac ttctgatatc tctcttcata ttttgcaacc aattcaggat ccggttctac
    20401 tgtatcaaca actttggcaa atttcttacc gatggtttct acatccggat aagcaccgca
    20461 gcccactgct gccagcatag ctccacccat ggacggtcct tcttcgttct ccagaacatc
    20521 aaccttcagg ttcataacgt tagcaataat cttcttccaa agcgggctct tagctccacc
    20581 accgcagatt tttgttctct caatcttgat tccaagactt cttgcaactt ccagagaatc
    20641 acgaagtcca aatgcaacac cttccagaac agcctgtgtc atatcagctc ttgtgctgtc
    20701 catggacatt ccgaagaata cacctcttgc atccgggtta ttgtgcggag aacgctctcc
    20761 catcaggtat ggcaggaaga acacattatt ctctccaagc ttctgaatcg gagcctgctc
    20821 tgctgcgaaa tcctttgtct gaagaatctc ctctgcccac catttgttac aggaagctgc
    20881 gctgagcata catcccatca gatgataact tccatctgca tggcagaaag aatggagtgc
    20941 attattttca tctacgccaa aattcttgct ggaaataaat acagttccgg atgttccaag
    21001 agaaatattg cactgtccat caccaactgt acctgttcca acagctgctg ccgcgttatc
    21061 tccggcacct gcaacaactt ttacatcttc tgagaatcca agttcttttg caatttcagg
    21121 tttcagagtt cctactactt cccagctctc atacagtttc ggaagctgtt cttctgtgat
    21181 accgcagatt tccagcattt cctttgacca gcaacggttc tttacatcaa gcagaagcat
    21241 accggaagca tcggaaacat ctgtgcagaa agaaccagac agacgatatg ccaggtaatc
    21301 tttcggcagc ataattttaa ctactttctt gaaattctcc ggctcatttt tctgcatcca
    21361 gagaatcttc ggtgctgtaa atcctgcaaa agcaatattt gctgtatact cagagagttt
    21421 ctcttttccg atcacagtat tcagatactc tgtttcctcg cctgtacggc catcgttcca
    21481 gagaattgca ggacggatta cgttgtcatc tttgtccagg gttaccagac catgcatctg
    21541 accgccaaaa ccaattccag ctaccttagt tctgtcaata tcctttgtca gttctttcat
    21601 accttccatg ctctgtgcaa accagtcttc cggtttctgc tcagaccagc ctggatgtgg
    21661 gaaaaataac gggtattctt ttgaaacaat attacagatt tttcctgaat cttccataag
    21721 aagaagtttt acagcggaag taccaaggtc aataccaata taatacataa ttttctctcc
    21781 tattagtctt tattgcatta ctgcatttca ttgctgttcg tttatctgaa ataaatcgcc
    21841 agattgctct taccaggcaa ttatatcttc gtatctttca tatgaagttc attcagattt
    21901 ttattgaagt taatttctca cactcattta atctaataca tcccagggta aacccccggg
    21961 atgccttata aattgtcgtg tcagtctatt attttttcaa tcttgattca atactgttga
    22021 attctgatta gccccatgga ttctctgttg ggtatcttac gcctgccggc tggttgtatc
    22081 caatctcttc aaccggaaca ccgatgtatt tgaatacttc aaacagagct tttccataat
    22141 gtccgaatgc tactgctccg tgatgtgggt atcctccctc gatcagtaca tgacggtaga
    22201 aacgtcccat ttccggaata gcgaatacac cgatagaacc aaaggatttc gttgcaacag
    22261 gaagaacttc accatgtgca atatatccac ggagtttgtt atcagctgtg ctctgcagac
    22321 gatagaatgt gatatctcca ggtacgatat ctccttcaag agttccgttt gtaacctcta
    22381 ccggaagaga tcttgccatg atcatctggt tcttcatctc acagaaggaa agcttgctgg
    22441 aagctgtatt tccacaatgg aatcccataa atgtatcttt cagtgtgtag ttatatttgc
    22501 cttcgataga ctctttgtac atatccttcg gtacagagtt gttgatgtca agcagtgtaa
    22561 ctgtatcctg gcttacaaca gttccgatga actcacttaa tgtaccatag atatcaactt
    22621 cacaggatac cggaatgccc tgagcagtca gacggctgtt tacatagcaa ggaacaaatc
    22681 caaactgtgt ctggaatgcc ggccagcatt ttcctgttaa tgttacatat ttacgatatc
    22741 ctctgtgagc ctctacccag tctttcagag tcagttcata ctgagcaagt ttctcaagaa
    22801 tttcaggttt cttgtttcct gcaccaagtt cttcttccat ttctttaaca actgccggga
    22861 ttctctcatc tcctgcatgt ttgttgaatg cttcgaacag atcaagttca gagttctctt
    22921 cgatttcaac accaaggttg taaagctgtt tgatcggagc gttacaagca aggaagtttg
    22981 ttggacgtgg tccaaagctg atgatcttta agttgcttaa tccttcaact gctcttgcga
    23041 ttggaaggaa gtcatggatc atatctgcgc agtcttctgc atcaccaacc ggatattccg
    23101 gaatatatgc ttttacatta cgaagctgta agttgtagct tgcatttaac ataccgcagt
    23161 atgcatctcc acgtccctgg atcaggtcgc cctgtgtttc ttcagctgct gcacagaaca
    23221 tcttcggtcc ttcgaagtgt ttagcaaga
//
