LOCUS       gnlProkkaMHLMBBNI_85   13850 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MHLMBBNI_85.
ACCESSION   gnlProkkaMHLMBBNI_85
VERSION     gnlProkkaMHLMBBNI_85
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 04:03:18
            Original ID  :: gnl|Prokka|MHLMBBNI_85
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 187097
            Orig. end    :: 200947
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13850
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:12661]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12661
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..13850
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13850
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             88..1239
                     /locus_tag="ctg23_152"
                     /transl_table=11
                     /translation="MEIIKDLPEVFEEFAEQRKNSFLAIKKIKDQNIPVIGSYCTYFPQ
                     EIAMAMGAASVGLCSMSDETIPVAEQTLPKNLCPLIKASYGFAVTDKCPFFYFSDVVVG
                     ETTCDGKKKMYEFMSEFKDVFILELSHKQTEAALQYWKSEIIRFKEYLEKKFEVEITEE
                     KLREAVRISNEGRRALKDFYELMKQDPAPMKGENLYNVLYGTTFKFDRSKVPAEIDALT
                     VKLKEEYAAGKNEGKKHRILITGCPMGGATMKVVKAIEENGGVVVAFENCSGAKSVDRL
                     IDENDPDIYEAIARRYLNIGCSVMTPNPNRFELLNELIDEYQVEAVVEMTLQACHTYNV
                     EAGKVGRFVREEKKIPYLHVETDYSQSDVGQLNTRIAALIEML"
     CDS             complement(1499..1612)
                     /gene="allorf_188596_188709"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_188596_188709"
                     /protein_id="allorf_188596_188709"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTCCLMVMNIRKALSAGKIHPTERASVFCPYFLVSGL"
     CDS_motif       complement(1562..1612)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MTCCLMVMNIRKALSAG"
                     /locus_tag="allorf_188596_188709_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(1499..1561)
                     /prepeptide="core"
                     /locus_tag="allorf_188596_188709_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.50"
                     /molecular_weight="2210.6"
                     /monoisotopic_mass="2209.2"
                     /core_sequence="KIHPTERASVFCPYFLVSGL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTCCLMVMNIRKALSAG"
                     /leader_location="[1561:1612](-)"
                     /alternative_weights="2228.6"
                     /alternative_weights="2246.6"
     CDS             1704..4385
                     /locus_tag="ctg23_153"
                     /transl_table=11
                     /translation="MKSNYKIFTAVFLSAIMTAAAPLTVCGAEVFSAGESFSDGTGSIP
                     AILTDMVLPGGEIGTEYQVQLEADTDVSWSLEEGSELPAGLTLSSGGVISGTPQKEGSF
                     SFTVQADNGIGVSSQELSLYVAQREQEPVIKQYELTSGTALIDLGIHAEGEQSRKRLFL
                     YNAGTDSLHLSDFPQSRYFDFSYAPIFDTNTDEEMQPGSCAAVDIDDKKDLPAGNYEET
                     VTFETKEGASCKVTLKVIVGASSEKDYELSIETGTEEEFTESDFYDPEFRVEKYVVVRN
                     SGKKETRIRIDTSGLKNFEVDDQMAKWTEDYEEQDSKKLLKPGETLYFYILPKQEYGIY
                     DESFAFLADDGSRYPLHVTMNREKNPTEKKQLEITEKSAGGFPTMQWGYKTLPEAKTYI
                     LKNVTDTDMKLSFNRSKECSVLLSGNAYLAPGESTELRLWPKLGLSVGKYSFQVTVTAK
                     TVAGEHLTTQNLYNSFIVGDRTYQGLADAVAPVTGITNGAEKTADALHLPNSLEVYGAE
                     VNGEKTTFSASVKWDVENCAYDPKSKAAQSFLVNGSLELNEDENNEGLDTAVQIMVQVD
                     AYQTLNRPVIDTRWTRVITNYAMLYLRDLSNEADGYQFVTAKSQKDLKKGNYTAQTKIT
                     NSELNQYPELKYIPEGTHSLYCRAYKENSSHVMEYGEWSDGVPVTVKAKTPDAPVVQKV
                     QVKKNDVRIVLNSKGEEPDGYDVVAARSKNGKEPSDYIKVKSGYSGSSKELILRGVPAG
                     TWYIGVHAYKYLNGSNTKVLSKWAEVRKVTVKTSLVTGKPAVKSAKVSRQGTKRNVAVT
                     FTVPKSCDGTDWVLAKKVSKSDNGSYTGVSSYAYTKKNQTKTTVVFKNVKPGVYYLAGR
                     AYVKGYAKSYTKWSKIKKIVVK"
     CDS             4625..5383
                     /locus_tag="ctg23_154"
                     /transl_table=11
                     /translation="MKQKKIAIIMAGILAAAAAMTGCAEQNKTETQVDYTQNSQEKSEQ
                     TKQKTAEKSQPDKKQVNKSTSGGKENSNQTADKKTKVFASSNNAGDVQNSENGTDSTAG
                     TDTDDSQTTGVDTSASEDNGSTGNGGTQSDQRADQAMIYDSEGNGRLISEADDGNWYDS
                     DGNYYGSWEDIEDAMVNENGVTDQDGNKYYWTAPHDASEEVTDPYDLYSWDPGTNSYIP
                     FQAAESDCSPIGRGNGWYYYDEDSGEYVPW"
     CDS             complement(5529..6422)
                     /locus_tag="ctg23_155"
                     /transl_table=11
                     /translation="MTKTEKAVTWAIKIANDPAHGYDQDNRWGPDYDCSSLVISAWQQA
                     GVPVKTKGATYTGNMKSVFLSCGFKDVTSKVNLSTGSGMKRGDVLLNIASHTVMHIGNG
                     QVVSASKNENNGYHGGKPGDQSGKEIKLQSYYNFPWDCVLRYTEDSSTTDPDPEPQPTA
                     GNAKIRKGQGYANKFANAGISITGKRDAATKKAGVKVLQTALNRDYGAGLDVDGIWGTN
                     TDNALGQHYVKNGETQYMVTAAEILLLLRAYDPNGVEIPGTFGSGLLSAVKAFQKAQGL
                     TVSGTCDRNTFLKLIS"
     CDS             complement(6610..6945)
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 60.6; E-value: 4e-18)"
                     /gene_kind="other"
                     /locus_tag="ctg23_156"
                     /transl_table=11
                     /translation="MKNNTIGKRIAEARINRNITQEHLEELSGLSVSTISRIETGKYMP
                     TIENLLKLSEILDVGLDYFLYDLLPHNKDIQSPAIQDAISIMNQMGERQTEYIVKILKI
                     YQASHQD"
     CDS             7064..7618
                     /locus_tag="ctg23_157"
                     /transl_table=11
                     /translation="MDEYTKDLYTMMFSLQTLQNQGITIRETVYKSLDKLLLWNKESEN
                     SKYLELALLHMQAYANMGFALDEENKTIREILKKTGKTREDFFPKGYLLGKRIKLTKSQ
                     VRGMIGRWRPSRDSPMTIGELVDDIIRKVKNHEEGRYIYQYHRTDVTTKGDIEVYELVI
                     NKDESYFYDVKKFRFYTFMEE"
     CDS             7624..8331
                     /locus_tag="ctg23_158"
                     /transl_table=11
                     /translation="MIRIMILDDDEMYLKKEKEITEHYFAEKNIDCTVTTYQNVEWFLL
                     GLKEEKFDMYLLDIRMPGENGIEAAREIRRLYPDPVIIFITNFVDYAIEAYEVNTYRYI
                     PKECLKEKLSQAYDALLPVIMEKEERYYIINKRNEVEKLAYSDIFYMKKEGKYVIFVHR
                     RGEVKIRASLSTVEKELNSKEFIISDRGYLANIQHVMKMKGRDLYMRDGNIITVGRERF
                     KGVREAILNYWGV"
     CDS             8335..9834
                     /locus_tag="ctg23_159"
                     /transl_table=11
                     /translation="MLKVLLYGLATFMETGIGVWIFGQMFPKRKVLKRKQYFSMWLMYL
                     WIMIGAYTYPKLFLHVNRIHGYLGCIIAFYLSGILGMTIFIVRCKEWDLIKVIGFILML
                     AQLECQYWNSYQSIIMILLGNIVPVLYLYIFYQCSLWDAYLWEIIYLANIALLKEPYVA
                     YVGTFKNRSFIDFFLWPREHLYSEILYVIIIYSMILLMNKYICISRWINPLLKEHKKYL
                     FIMTCAEVYVLSILMHFGEGKITENNLTITLIVLMILVLGLLFVYLKMQERLIKSEKNI
                     LNMRFETMTEQYKELKKSYDKYRCLLHDEKHMILYLNECLDNRDIKEAKKILRGYKELT
                     FTKDKAIWTGISTLDFMLNIKIEKMREQEIEFKINSQVEKIPMEELDFIMMMGNLLDNA
                     IESAVKCRKGERYIVFKIYNINDIFGIKIKNSSISKPTMVGDDFLTEKKEKDIHGWGIK
                     SVKKILEKYNGELNFKYDNSFFETHVIIEDDISIMENIYEK"
     CDS             9824..9964
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg23_160"
                     /transl_table=11
                     /translation="MKNNEKNFIGDINKELEEIEKLDILEEIEESLLTMLGSVNSLFCC
                     H"
     CDS_motif       9824..9937
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MKNNEKNFIGDINKELEEIEKLDILEEIEESLLTMLGS"
                     /locus_tag="ctg23_160_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9938..9964
                     /prepeptide="core"
                     /locus_tag="ctg23_160_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="904.1"
                     /monoisotopic_mass="903.4"
                     /core_sequence="VNSLFCCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNNEKNFIGDINKELEEIEKLDILEEIEESLLTMLGS"
                     /leader_location="[9823:9937](+)"
     CDS             10001..12661
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     756.5; E-value: 7.5e-229)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_161"
                     /sec_met_domain="DUF4135 (E-value: 8.5e-93, bitscore:
                     304.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8.6e-52, bitscore:
                     169.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIIQRIVIFDIYRKKTNHDLRGNNVKEQYDYYEKKYLNNATYV
                     KSLLQEYPELKRLLELKNNSIQRAECEIRKSLYAEKEQIQKIFCDGRKFSGTVGIYMSK
                     GDIHRGGRSVAKVELDNGTILYYKPHSLDKNIKYQELYNYLCRKTGISCRTVRYLSHDS
                     YGWEEKIENIPCKNESEVEHYYFRMGIHLFLGYALGATDLHGENIIAHGEYPVIIDMET
                     YPGYLKQQSEKDGSSVEEKINKSTEIKLANSVIHTGMLPVLTWGRGNRGVLISAMGTEE
                     KIKTPFKLPVVKDDKTSDIHIEYEPVEMQIKECIVRLNDQVINAADYTECIIRGFCRAY
                     MVAMADKKVEVMLSGFFDGRSRVVLRHTQQYAMYLMASFHPDYMKSRECRKALLNVIHK
                     EGESSFMKGIHDYEIESLLEMDIPCFEIDANSRSVYDGNGGEHKEYLPCTPYESWRMHM
                     KQMSYSDMECQCDYIRLSMEMLKASDGKKKMFPTRIKGYDTDKERKIYSQIRKIVHRIC
                     SRAIIREQSAGWAGLQFWDNGHWNLRSGGIYLYDGISGIVLFLAKYLHDFEEKNASAEE
                     IYHLAVLRLKAYTDEIHKKQIYDKNLLTGIVNGESSVVYTYLYLFKLTGKRVWMIYAEK
                     HFSIIERVWKEDSQLDYLSGNAGAIVVAVMLYKETGNLKYYEIAADMEKDLWKKGQETG
                     NGYGWRLKGTDGPLAGMSHGNSGFMMAYAMLYECDHKVEYADKIQLLLRYEDSLYSEKA
                     GNWKDLRESSGESFMNAWCHGAPGILLSRMKLEELFPEDMQIKKDRLNAADSLFYGEQD
                     EKICLCHGMSGNLLIMKKYLRKYGNKKMKEQYEALCDCLLFQLDHPAKISGTEYLNLAF
                     MNGISGTGMALMEII"
     CDS             complement(12714..13238)
                     /locus_tag="ctg23_162"
                     /transl_table=11
                     /translation="MKTLTELIQNYQNGIPNSDSEILKRMEPLVKGYASRIHCMEREDS
                     IQELYLTLLKTLPYLSSSSSEGECIRYMQTSVENRYRSLCRSCLSEPEKDDFDSCSVSL
                     QAPDSFDDTYYDVTAYINSYPSDSVQRKILSMYFYQDKSDAQIAQKLKLSRQYVNRMKK
                     KLILRYISENK"
     CDS             13539..13778
                     /locus_tag="ctg23_163"
                     /transl_table=11
                     /translation="METTVMNVAVSHGIWAVLAVFLLVYIVKSNEKRDEKQEEREKNYQ
                     SVIEKLTEKLEILHQVQSDLSEIKENLFGKHKQE"
ORIGIN
        1 agaggataat aaggactgca acagttggcg aatggtatga aagaagtaaa aaataatata
       61 aaaacgatag aaagatgagg tacaaagatg gaaataatta aagatttacc agaagtattt
      121 gaggagtttg cggagcagag gaagaattca tttcttgcta tcaagaagat taaggatcag
      181 aatatcccgg taattggttc ttactgtaca tattttccac aggagattgc aatggccatg
      241 ggagctgctt ctgtaggttt atgttccatg tctgatgaaa caatcccggt agccgagcag
      301 acattgccga aaaatctctg tccactgatc aaggccagtt atgggtttgc agtgacagat
      361 aaatgtccat tcttttattt ttcagatgtt gtagttggtg agactacctg tgacggaaag
      421 aaaaaaatgt atgaatttat gtccgaattt aaggatgtat ttattttgga gctttctcat
      481 aaacagacag aggctgcact tcagtactgg aagagtgaga ttatccgttt caaagaatat
      541 ctggagaaga aatttgaggt ggagatcaca gaggagaagc ttcgtgaggc agtccgcatc
      601 agcaatgagg gacgtcgtgc tttgaaagat ttctatgaac tgatgaaaca ggatccggct
      661 ccaatgaagg gtgagaatct ttataatgta ttgtatggaa ctacctttaa gtttgaccgt
      721 tccaaagtcc cggcagagat tgatgcactg acagtgaagc tgaaagaaga atatgcagca
      781 ggcaaaaacg aaggaaagaa acatcgtatt ctgatcaccg gatgtccaat gggcggagct
      841 accatgaaag tagtaaaagc aattgaagaa aatggcggtg tggtagttgc ttttgaaaac
      901 tgctccggtg caaagagcgt agacagactg attgatgaaa atgatccgga tatttacgaa
      961 gcaattgcaa gacgttatct gaatatcggc tgttctgtta tgactccgaa tccgaaccgt
     1021 tttgaactgt taaatgaact gatcgatgag tatcaggtag aagctgttgt ggaaatgact
     1081 cttcaggcct gtcatactta taatgtggaa gccggtaaag ttggcagatt tgtaagagaa
     1141 gagaaaaaga ttccttatct gcatgtggag acagattatt ctcagtctga tgttggacag
     1201 ctaaatacac gtattgcggc tctgatagaa atgttataac tgtgaaggta ttataagatt
     1261 atacgaaaaa tgtcgaattg tatgtatttt attatagcaa tcctttgaaa taatgcatct
     1321 taatccagcc catcagagtg tgaaatcctg cgtcagatat ctttgccgtg cgtcagcgcg
     1381 cctgcagata tcttccttgt ctttcgcgct ctgctgaact gtcttaaatg cattatttac
     1441 gaggattgct atagaaaaaa atatgtataa gcaataaatg acaagcgact gatcaaattt
     1501 ataaaccaga aactaaaaaa tatggacaga aaacagaagc tctctctgtg ggatgaattt
     1561 ttccggcgga cagggctttt ctgatattca tgaccattag acaacatgtc attccgtaat
     1621 tacagaaaca ttcccgtcca gtggtatatt aatattaatt aggtaaattg atacttttat
     1681 attttattat ctggaggaga agaatgaaaa gtaattacaa aatttttaca gcagtttttt
     1741 tatcggcaat tatgacagca gcagctccgt taacagtatg cggggcggaa gttttttcgg
     1801 cgggagaatc tttcagtgat ggaacaggga gtattcctgc catattgaca gatatggttc
     1861 tgccgggtgg agagattgga acagaatatc aggtacagct tgaagctgat acagatgtga
     1921 gctggagtct ggaggaggga agcgagcttc cggcgggact tacgttgtct tccgggggag
     1981 tgatcagcgg aacaccgcag aaggaaggga gtttcagctt tactgtacag gcggacaatg
     2041 gtattggagt ttcttcacag gaactgagcc tttatgttgc acagcgtgag caggaacctg
     2101 ttataaagca gtatgagctg acatcaggta ctgctttgat cgatctggga attcatgcag
     2161 agggagaaca gtcacgtaag cggttatttc tttataatgc aggaacagat tcgcttcatc
     2221 tctctgattt tccgcagagc agatattttg atttttccta cgcaccgatt ttcgatacaa
     2281 atacggatga agaaatgcag cccggaagtt gtgcggctgt ggacattgat gataagaagg
     2341 atctgcctgc cggaaattat gaagagacag tgacatttga gacaaaagag ggtgcttcct
     2401 gtaaggttac tctgaaagta attgtgggag cttcctctga aaaagattat gagctgagta
     2461 tagaaacagg tacagaagaa gaatttacag aaagcgattt ctatgacccg gaatttcgtg
     2521 tggagaagta tgtagtggtc agaaattcag gaaaaaagga aaccagaata cggatagata
     2581 cttctggtct taagaatttt gaagtggatg atcagatggc aaagtggaca gaagattatg
     2641 aggaacagga ttccaaaaag ctgctgaaac cgggagaaac actttatttt tatatattgc
     2701 cgaagcagga atacggaatt tatgatgaat cgtttgcatt tctcgcagat gacggaagca
     2761 gatatcctct tcatgttaca atgaacagag agaagaatcc gacagaaaag aagcagctgg
     2821 aaattactga aaagtctgcc gggggttttc cgacaatgca gtggggctat aagacacttc
     2881 cggaagcaaa gacatatatt ctgaaaaatg ttactgatac agatatgaag ctgtctttta
     2941 accgtagtaa agaatgtagt gtgttattat ctggaaatgc ttatctggca cctggggaga
     3001 gcacagaact gagactctgg cccaaactgg ggctttcggt gggaaaatat agttttcagg
     3061 tgactgtgac tgcgaaaaca gtggcaggag aacacctgac aacgcagaat ctgtataatt
     3121 cttttattgt aggagaccgg acttatcagg gactggcaga tgctgttgcg cctgtgaccg
     3181 gaattaccaa tggtgcagaa aaaactgctg atgctttgca tctgccgaat tcgctggaag
     3241 tctatggcgc cgaggtgaat ggagagaaaa caacattttc tgcgtctgtg aagtgggatg
     3301 tggagaattg tgcttatgat ccgaaaagca aggcagctca aagttttctg gtcaacggat
     3361 ctctggaact gaatgaggat gaaaataatg aagggctgga cactgccgta cagataatgg
     3421 tacaggtgga tgcttatcag acattaaaca gaccagttat tgatacgcgg tggaccagag
     3481 tgatcacaaa ttatgcaatg ctttatctga gagatctttc caatgaagcg gacggctatc
     3541 agtttgtgac agcgaaatct cagaaggatc tgaaaaaggg gaattatact gcgcagacaa
     3601 aaattacaaa ttctgaactg aatcaatatc ctgagctgaa gtatattccg gagggaacac
     3661 atagtcttta ttgcagggca tataaagaga acagcagcca tgttatggaa tatggggaat
     3721 ggtcagacgg ggttccggtt acggtaaagg caaagactcc ggacgcacct gtggttcaga
     3781 aggtgcaggt gaagaaaaat gatgtcagaa tagtacttaa cagcaagggt gaggaaccgg
     3841 acggttacga tgttgttgct gccagaagta agaacggaaa agaaccatcg gattatataa
     3901 aggtaaagag tgggtattcc ggaagcagta aagagcttat cttacggggc gtaccggcag
     3961 gaacgtggta tattggcgta catgcttata aatatctgaa tgggagcaat accaaagtgc
     4021 tcagtaaatg ggcagaggtc aggaaggtaa ctgtaaaaac aagccttgta acaggaaaac
     4081 ctgctgttaa atcagctaag gtttccagac agggaacaaa aagaaacgtg gcggtgacgt
     4141 ttactgttcc aaagtcctgt gatggaacag actgggtact ggcaaagaaa gtttccaaat
     4201 ctgataatgg cagctatact ggtgtaagca gttatgctta cacaaagaaa aatcagacaa
     4261 aaaccacggt ggtctttaaa aatgtgaagc ccggagtcta ctaccttgca ggacgtgcct
     4321 atgtaaaagg ttatgcaaaa agttatacga aatggtcgaa aataaagaaa atagttgtga
     4381 aataagtact gctgccattt gtttcacaga gatttcactt ttaagaaaaa agatattccc
     4441 cttttaccaa gcgtttataa ggcaaaatta tggggtaaag attttggaaa aaaatggggt
     4501 acatttcatg acagataagg gacatatgag gcatcgaagc ctgtgaagta tgtcataatg
     4561 aacaggaaaa gcacattatg ataaaggcat cgacattttt aacaaatgta gaaaggataa
     4621 caaaatgaag cagaaaaaga ttgcaattat tatggcaggg attttagcag cagcggctgc
     4681 tatgactggc tgtgcggaac agaataaaac agagacacag gttgattata cgcagaactc
     4741 acaggagaaa tccgaacaga caaaacaaaa aacagcagaa aaatctcagc cggataaaaa
     4801 acaggtaaat aaaagtacat ccggtggaaa agaaaattca aatcagactg cggataagaa
     4861 gacgaaagta tttgcctcat ccaataatgc aggcgacgta cagaattcag agaatggaac
     4921 agacagtact gcgggaactg atacagacga ttcccagacc acaggggtgg acacttctgc
     4981 atctgaagat aatggttcaa caggtaatgg tggtactcaa tctgatcaga gggcagatca
     5041 ggcaatgata tatgacagtg agggaaatgg aaggctgatt tctgaagctg atgatggaaa
     5101 ctggtatgac agtgacggaa attactatgg aagctgggaa gatattgaag atgctatggt
     5161 aaatgaaaat ggtgtcacag atcaggatgg caataaatat tactggacag cacctcacga
     5221 tgcatcagaa gaggtcacag atccgtatga cctgtattcc tgggatccgg gaaccaattc
     5281 ctatataccg tttcaggctg cggaatctga ctgtagtcct ataggcagag gaaacggctg
     5341 gtattattat gatgaagaca gcggcgaata tgttccgtgg tagaatataa aaatgcgaaa
     5401 agaagcagtt ttgagaccat tttaatgggt ttcaaaattg cttctttttg ttatatacat
     5461 gaatagtgaa ggggtatatc cgacagaatc aggggacaga attctgccgg atgtttatct
     5521 ggtaaagatc agctgatcag tttcaggaaa gtatttctgt cacaggttcc ggaaactgtt
     5581 aagccctgtg ccttctggaa tgcctttaca gcagagagaa gtcctgagcc aaaggtaccg
     5641 ggaatctcta caccgtttgg atcataagca cgtaaaagaa ggagaatctc agcggcagtt
     5701 accatatact gtgtttcacc attttttaca taatgctgtc caagagcatt gtctgtgttt
     5761 gttccccaga taccgtctac atccagaccg gcaccataat ccctgttcag agctgtctga
     5821 agaactttaa cgcctgcttt tttggtagca gcgtctcttt ttccggtaat agagattcct
     5881 gcattggcga atttattggc ataaccctga cctttgcgga tttttgcatt tcctgcagtt
     5941 ggctgaggtt caggatcagg atcagtagtt gaagaatctt cagtataacg gagaacgcaa
     6001 tcccagggga aattgtaata actctgaagt ttgatctctt ttccgctctg atctccgggt
     6061 ttaccaccat gatatccatt attttcattt ttgctggcag ataccacctg accattacca
     6121 atgtgcatta ctgtatgact tgcgatgttt aataatacat cgccacgttt catgccactt
     6181 cctgtgctga gattaacttt ggaagttaca tccttaaagc cgcaggacag aaaaacggat
     6241 ttcatatttc ctgtataagt ggctcctttt gtttttacag gaacaccagc ctgctgccat
     6301 gcggagatta ccagtgaaga acaatcgtag tccggtcccc atctgttatc ctgatcatat
     6361 ccgtgtgccg gatcgtttgc gattttaatt gcccatgtta ctgctttttc tgtttttgtc
     6421 atttttttat cctcctgaaa tttgattatt tatttgctca ccggtgatac atcttataaa
     6481 gagtgagaaa agggaaaaat gtaaacatga aatagaaaaa aataaaaagc atttcctgat
     6541 tgttgcttcg aggtcagaaa aatgcttttc gaggacaaaa acacgaaaat tgtcgaattg
     6601 taattatatt taatcctgat gagaggcctg atatattttc agtattttta caatgtattc
     6661 agtctggcgt tcacccattt gattcatgat tgaaatcgca tcctgaatag ccgggctttg
     6721 aatatcttta ttatgaggaa gcagatcata aagaaaatag tcaagtccca catcaagaat
     6781 ttcagaaagc ttaaggagat tttcgatagt aggcatatac ttacctgttt caatccggct
     6841 gatcgtactt acagataaac cacttaattc ttccaggtgt tcctgggtaa tattcctgtt
     6901 gatccgagct tctgcaattc tttttccgat agtattgttt ttcataaata aaaatccttt
     6961 cctttgataa agtttaacag acggaattaa atatgtataa ggatataaat gacaagtgac
     7021 taatcaaatt tgatatgttt tatgacagga ggaatatagg aatatggacg aatatacaaa
     7081 ggatttgtat accatgatgt tttctttgca gactttgcaa aatcagggaa ttacaatcag
     7141 agaaactgta tataaaagtc tggacaaatt actgttatgg aataaagaat ctgaaaacag
     7201 taaatatctc gaattagcgt tgcttcatat gcaggcttat gctaatatgg gatttgcttt
     7261 agatgaagaa aataagacaa tacgtgagat attaaaaaag acaggaaaga ccagagaaga
     7321 ctttttcccg aaaggatatc ttcttggaaa gagaattaaa ctgaccaagt cacaggttcg
     7381 tggtatgatt ggaagatgga gaccttccag agacagtccg atgacaatcg gagaactggt
     7441 ggatgatatc atcagaaagg taaaaaacca tgaggaaggc agatacattt atcagtatca
     7501 cagaactgat gtgacaacca aaggggatat cgaggtttat gagctggtca tcaataagga
     7561 tgaaagttat ttttatgatg tgaagaaatt cagattttat acattcatgg aggaataatt
     7621 gctatgataa gaataatgat tctggatgat gacgaaatgt atctgaaaaa agaaaaggag
     7681 attacagaac actattttgc agagaaaaat atagattgta cggtaacgac ataccagaat
     7741 gtggaatggt ttctgctggg attgaaggaa gaaaaattcg atatgtatct tctggatatc
     7801 cggatgccgg gagaaaacgg aatagaggca gcaagagaga tacgcagact ttatccggat
     7861 ccggttatta tatttattac aaattttgtg gattatgcaa tagaagcata tgaggtaaac
     7921 acctatcgtt atatccccaa agagtgtctg aaggaaaaac tttcgcaggc ttatgatgcg
     7981 cttcttcctg taattatgga gaaagaagag cggtactata tcataaataa aagaaacgaa
     8041 gttgaaaaac tggcatattc tgatattttc tatatgaaaa aagaaggaaa atatgtgatt
     8101 tttgtgcaca ggcgtgggga agtaaagatc agagcaagtc tgtcaacagt agaaaaagaa
     8161 ctgaattcaa aagaatttat tatatctgac agaggatatc ttgcaaacat ccaacatgtg
     8221 atgaagatga aaggaaggga tctttatatg cgggacggta atattattac agttggcaga
     8281 gaaagattca aaggtgtcag agaagcaatt ctgaattact ggggggtatg aagaatgctt
     8341 aaagttttat tgtatggact ggcaacgttt atggagactg ggataggtgt ctggatattt
     8401 gggcagatgt ttccgaagcg gaaggtactg aagagaaagc aatatttttc gatgtggtta
     8461 atgtatttat ggataatgat aggggcatat acatatccta agcttttttt gcatgtaaat
     8521 agaattcatg gatatttagg atgcataatc gcattctatt tatctggtat attaggaatg
     8581 actatattta ttgtaagatg taaagagtgg gatttaataa aagtaatagg atttatattg
     8641 atgcttgctc aacttgaatg tcaatattgg aattcttatc aatcaataat tatgatattg
     8701 ttgggaaaca tagttcctgt tttatatttg tatatatttt atcaatgcag tttgtgggat
     8761 gcttatttgt gggaaataat ctatttagcg aatatagcat tgctaaaaga accatatgta
     8821 gcctatgtag gaacttttaa gaatagaagt tttattgact tttttttatg gccacgtgaa
     8881 catttatata gcgaaattct ttatgtgatt attatataca gtatgattct gctcatgaat
     8941 aagtacattt gtatatcaag atggataaat ccgttgttga aggaacataa aaagtattta
     9001 tttattatga catgtgctga ggtatatgtt ctaagtattt taatgcattt tggtgaagga
     9061 aaaataacag aaaacaatct gacaattaca ttaattgtct tgatgatatt ggttttaggt
     9121 ttgttgtttg tatatttaaa aatgcaggaa agactaatca aatcagaaaa aaatattcta
     9181 aatatgcgat ttgaaacaat gacagaacaa tataaagaat taaaaaaatc atatgacaaa
     9241 tatcgatgtc tattgcatga tgaaaaacat atgattttat atttaaatga atgtttagat
     9301 aatagggata taaaagaagc taaaaaaatt ctacgaggtt ataaagaact aacatttaca
     9361 aaagataagg caatatggac tggaatatct acattggatt ttatgttgaa tataaaaatt
     9421 gagaaaatga gagaacagga aattgaattt aaaataaatt ctcaggttga aaagattccg
     9481 atggaagaat tagattttat tatgatgatg ggaaatcttt tagataatgc aattgaatct
     9541 gctgtcaaat gtagaaaagg tgaaaggtat attgtattta aaatatataa tataaatgat
     9601 atatttggga ttaaaattaa aaattcaagt atatcgaaac caacgatggt tggagatgac
     9661 tttttgacgg agaaaaagga aaaagatatt catggctggg gaataaaaag cgtaaaaaag
     9721 atattagaaa aatataatgg agaattaaat tttaagtatg ataattcatt ttttgaaact
     9781 catgtaatca ttgaagatga tataagtata atggagaata tttatgaaaa ataatgaaaa
     9841 gaactttata ggagatataa ataaagaatt agaagaaatt gaaaaactgg acattttaga
     9901 agaaatcgag gagagtctgt tgacaatgct tggatcagtt aattcactat tttgctgtca
     9961 ttagtaaaaa acagtaacta acagtaggaa gtatattaaa ttgataaaca ttattcaacg
    10021 aatagtaata tttgatatat atcgaaaaaa aaccaaccat gatcttcggg gtaataacgt
    10081 aaaagaacaa tatgattatt atgaaaaaaa atatcttaac aatgcaacat atgtaaaatc
    10141 tttactgcag gaatatcccg agttaaaacg tctgcttgaa ttgaaaaata actctatcca
    10201 gagagcagaa tgtgaaatca ggaaatctct ttatgcagaa aaagaacaga tacaaaaaat
    10261 attctgtgat ggaagaaagt tttccgggac tgtgggaatt tacatgtcga aaggcgatat
    10321 acacagagga ggacgaagtg tggcgaaggt agaattggat aatggaacaa ttctgtacta
    10381 taagccacat agtcttgata agaatataaa atatcaggaa ctttataact atttatgcag
    10441 aaaaacagga atttcctgca ggacggtacg gtatttatct catgattcct atggatggga
    10501 agaaaaaatt gagaatattc cctgtaaaaa cgaaagcgag gtggagcatt attatttcag
    10561 aatgggcata catctgtttt tgggatatgc ccttggagca acagatcttc atggtgaaaa
    10621 tattatcgca catggagaat atcctgtgat tatcgatatg gagacatatc cgggatattt
    10681 aaaacaacaa tcagagaaag acggaagtag tgtagaagaa aaaataaaca aaagtacaga
    10741 aataaaattg gcaaattcgg ttatacatac aggaatgctc cctgttctca catggggcag
    10801 aggaaacaga ggagttctta taagtgcaat gggaacagag gaaaagataa aaacaccgtt
    10861 taaacttcct gtggtaaagg atgataaaac atctgatatc cacatagaat atgaacctgt
    10921 ggaaatgcag ataaaggaat gcattgtaag actaaatgat caggttatca atgcggcaga
    10981 ttatacggaa tgcattatca gaggattttg cagagcgtac atggtggcaa tggcagataa
    11041 gaaagtggag gtgatgttgt ccggcttttt tgacggacgt tccagagttg tactgcggca
    11101 tacccaacag tatgcaatgt atcttatggc ttcgtttcat ccggattata tgaagtcaag
    11161 agaatgcagg aaagctcttt tgaatgtgat tcacaaagag ggggaatctt cttttatgaa
    11221 ggggattcat gattatgaaa ttgagagtct tctggaaatg gatataccct gctttgagat
    11281 tgatgcgaac agcagatctg tttatgatgg aaatggcgga gaacataaag aatatctgcc
    11341 ctgtactcct tatgagtcat ggcgaatgca tatgaagcag atgagttact ctgatatgga
    11401 atgtcagtgt gattatatca ggctgtccat ggaaatgctg aaggcatctg atggaaagaa
    11461 aaagatgttt ccgaccagga taaagggata tgacacagat aaagagcgca aaatatacag
    11521 tcagatcaga aagatagttc atcgaatctg cagcagagca attatccggg aacagagcgc
    11581 cggctgggcg ggtctgcaat tctgggataa tggtcactgg aatctcagat caggtggaat
    11641 atatttatat gatggaatat ccgggatagt cttgtttctt gcaaaatatc ttcatgattt
    11701 tgaagaaaag aatgcaagtg cagaagaaat ttatcatctt gctgttttga gattgaaagc
    11761 ttatacagat gaaatacaca aaaaacagat ttatgataaa aatcttctga caggtattgt
    11821 aaatggagaa agctcggtgg tatataccta tctttatctg tttaaactta caggaaaaag
    11881 agtgtggatg atttatgcgg aaaagcattt cagcattatt gagagggtat ggaaagaaga
    11941 ttcacaactg gattatctga gcggaaatgc cggagctatt gtagtggcag tgatgttata
    12001 taaagaaacc ggaaatctga aatattatga aatagcggca gatatggaaa aagatttgtg
    12061 gaagaaagga caggaaaccg gaaatggata cggatggaga ttaaaaggaa cagacggacc
    12121 gctggctgga atgtctcatg gcaacagtgg atttatgatg gcttatgcaa tgttgtatga
    12181 atgtgatcat aaagtggaat atgctgataa aatacagctt ttgctgagat atgaggattc
    12241 tctgtactca gagaaagccg gaaactggaa ggatttacga gagagttcag gggaaagctt
    12301 catgaatgca tggtgccatg gggcgccggg aatcctgctt tcacgaatga aactggagga
    12361 gctgtttcct gaggatatgc agattaaaaa agacaggtta aatgctgcag actctttgtt
    12421 ttatggagaa caggatgaaa aaatttgtct gtgtcatggg atgtccggga atttacttat
    12481 tatgaagaag tatcttcgaa aatatggtaa taaaaaaatg aaggagcaat atgaggcgtt
    12541 atgtgactgc cttttatttc aactggatca cccggctaaa atatctggga cagaatatct
    12601 gaatctggct tttatgaatg gcatttccgg tacgggaatg gcattaatgg aaattatatg
    12661 aaaactaagg gaacacctga agactgtaaa tttatggtca gcaggtgttt cttttatttg
    12721 ttttcggaaa tatatctgag aattagtttc ttcttcatcc gattgacgta ctggcgggac
    12781 agcttcagtt tctgagcaat ctgggcatcg cttttatcct gataaaagta catggacaga
    12841 atttttctct ggacactgtc cgaagggtaa gagttgatat atgcggttac atcataatag
    12901 gtgtcatcaa aactgtcggg agcctgtaat gaaacagaac aagaatcaaa atcatctttt
    12961 tcaggttcgg aaagacaact gcggcaaagg gaacgatatc tgttttcgac agaggtctgc
    13021 atgtatctga tacattcacc ttctgaggat gaagaactta aatatggcaa tgtctttaac
    13081 agagtaagat acaattcctg tatggaatct tcgcgttcca tgcagtgaat ccgggatgca
    13141 tatcctttca caagcggttc catacgtttg agaatttcac tgtctgaatt tgggatacca
    13201 ttttgataat tttggataag ttctgtcagt gttttcatag gtatctacct cctttttagg
    13261 ggaagtagta agaaaactgc tgatcagaaa ctaaaaaaga aaaaaattgt gagtttacaa
    13321 atggaagaga aaaaactctt tattaagtga gtttgcaaat tcaaattaat gataagagga
    13381 gaaaaaatat atggtaaaaa gagattggta gaataattgt agagaataaa actgtgactt
    13441 aaattggaac ggtaataata agaccagaaa agacttttag tggatggaat atagaaaaaa
    13501 tgcgtaataa aagaagatta agaggaggga ggtgaactat ggaaacaacg gttatgaatg
    13561 tggcagtttc gcatggaatc tgggcagtgc tggcggtatt tcttttggtt tatattgtga
    13621 aatcaaatga aaaacgagat gagaaacagg aagagcggga aaaaaattat cagtctgtaa
    13681 tagagaaact gacagagaaa ttagagattt tacatcaggt acaaagtgat ttatcagaaa
    13741 tcaaagagaa tctttttggt aagcataagc aggagtaaaa attcaggtat aaaattgtca
    13801 acgaatcatg aaagcttatc tcagcctata atgaaaatag gatactgact
//
