LOCUS       c00094_gnlPro..        13020 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NANAELEG_150.
ACCESSION   c00094_gnlPro..
VERSION     c00094_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 05:08:07
            Original ID  :: gnl|Prokka|NANAELEG_150
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13020
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13020
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[76:3020]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      77..3020
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13020
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13020
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(77..1756)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_1"
                     /sec_met_domain="HGD-D (E-value: 1.3e-17, bitscore: 53.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 2.4e-66, bitscore:
                     213.3, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTYYVCKYTPIELLESLGGECENFNHMPEGFDLADQVSHPNIC
                     GFGKTLLEGVMEGKIKELVLVSCCDTIRSVYDILLESGKLDFLYILDVLHCDSACSRER
                     MAVQLKGLAKAYAQYKGTEFDAGKFRAAFHAQEKITKSHIAVLGARMGQELFEMTSKAM
                     PLPVENDTCVHNRSVGNILPPEGASFDELMDWYAGEILGQIPCMRMMDPTGRKKLYNDP
                     SVAGIIYHTVKFCDFYSFEYAEIKNHTDVPLLKIESDYTIQSSGQLLTRLEAFAESIQP
                     ETLEQTIDGDTKGERKMGKGYFAGIDSGSTSTDVVILNKDHEIVTSIILPTGAGAAIGA
                     DRALAEALKEAGLQREDIDALVTTGYGRTAIKNGDKSITEITCHARGAHFLNPEVRTVI
                     DIGGQDSKVIRLDENGAVANFVMNDKCAAGTGRFLEMMARTMEMNLDQMSECGLEFKED
                     ITISSMCTVFAESEVVSLIAQNKATDDIVHGLNKAVAVKTAALIRRVGGEEKYMMTGGV
                     SKNKGLVKTLEEKLGTKLVISDKAQLCGALGAALFAADMADV"
     CDS             complement(1749..3020)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_2"
                     /sec_met_domain="HGD-D (E-value: 2.3e-56, bitscore: 181.2,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIETFGHYVENLTDKKPQSARRLLKTGWEAQNLKFRYMQDKRL
                     MPADRHLANLMMDTMLRPIQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCYLSASKA
                     ERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTFRTLADF
                     YQVPVFAIDVPWNQTTENVQYVADQLKDLKIFLEKNTGKTISEDRLKERLACSKRTLEN
                     YKKYQQMRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLEDIKKAPAAKGKHIY
                     WMHTIPFWSDAVRQELCFSEKAQIVGCELAETCEPDFDPENPFEAMAERMVYHSLNGSA
                     LRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDGDGCDRS
                     HGGEGQTSTRLGAFLEMLGGAENE"
     CDS             3264..5078
                     /locus_tag="ctg94_3"
                     /transl_table=11
                     /translation="MRSLTVYLKNYKKESILAPFFKFLEVVFDLIVPIVIAQIIDVGIA
                     NHDNGYIVQRFSILILMAALGLASTITAQFFAAKASVGFATELRQAVYDHVQHLSYTEL
                     DTLGTDTLITRLTDDVNQIQNGLNMGLRLLLRSPFIVLGSMVMAFTIDFKCALVFAVAI
                     PFLFLVVFVIMFLSIPLFKKVQGKLDTVTGLTRENLTGVRVIRAFCREKEAVAEFDTRN
                     QELTKLNLFVGKLSALLNPVTYVLINIATVILIQKAGVEVNLGGMQQGQVVALYNYMAQ
                     MIVELIKLASLIITLNKSAACAGRVADILKVKSTMDYPSSSTYSAQISKDLATATADAS
                     LSENAIVFNDVTFEYSKAGAPSLSHISFSVKKGQTVGIIGGTGSGKTTLVNLISRFYDA
                     SKGTVLLDGQNIENYTRSDLRSRIGVVPQKAALFKGSIRDNLKWGREDASDEDLWQALT
                     TAQGKEVVEGKPGQLDFMLEQNGKNLSGGQKQRLTIARALVKKPEILILDDSASALDFA
                     TDAALRKSLNRLDWKVTTFLVSQRSSSIQQADLILVLDNGTLAGKGTHAELLRTCDTYR
                     EIYFSQFPEERARYSSVSAGNIMKEVTV"
     CDS             5075..6841
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     286.7; E-value: 2.2e-87)"
                     /gene_kind="resistance"
                     /locus_tag="ctg94_4"
                     /transl_table=11
                     /translation="MSRSTIKDPAKSKSSETFFKVLRFIGRYRFLLILSIILAAVSVIL
                     QLYVPILFGNAIDQVIAQHQVNFEMMWYYLSRILVMVILSSAATWLMNVINNRMTYQTV
                     KDIRAKAIRHIQVLPLSYLDGHSTGDIISRIIADTDILSDGMLLGFTQLFSGIVTIIGT
                     LIFMFSKNFWITLMVIVLTPVSFLVAKFISSHTFQMFRKQSDARGRQTALIEEMIGNQK
                     VVQAFGYEEKSSERFAKVNEELQECSLKAVFYSSLTNPSTRFVNNIIYACVALVGAFII
                     PGGRLTVGGLSVLLSYANQYMKPFNDISSVVTELQNALACAGRIFDLLEEEPEVAEASE
                     TLKDVKGEVDIKNVCFHYDESKKLIEDFNLHVKPGMRVAIVGPTGCGKSTFINLLMRFY
                     DVNSGSISVDGKPIRDITRHSLRSSYGMVLQETWIKNGTVRDNISIGKPEATDTEIIEA
                     AKLTHSWEFIRRLPKGLDTMLNEDSLSQGQKQLLCITRVMLCLPPMLILDEATSSIDTR
                     TELQIQEAFERMMEGRTSFIVAHRLSTIRNADLILVMKDGSIIEQGTHDELIAKGGFYH
                     TLYNSQFAKVSE"
     CDS             complement(6928..8715)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M24"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_5"
                     /sec_met_domain="Peptidase_M24 (E-value: 6.5e-43, bitscore:
                     136.2, seeds: 437, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKERITALRARMKETGIDAYLIPTDDFHGSEYVGEYFKCRKYI
                     TGFTGSAGTAVIMQDMAGLWTDGRYFIQAADQLEGTGITLFKMGEPEVPTVHEFLKKNL
                     TQGRCLGFDGRTVSAKEAAELEKMLDENGVSLSVDHDLAGDIWENRPVLSCEPVTELDI
                     KWAGESRADKCARIRKAMEKKGADLFVLTSLDDIAWLLNIRGGDIHCCPVVLSYLVMTK
                     TEIRLFANEKAFQTDVLEALEKDGVTLFPYDSIYEYVKTFKKDKKVLLCKKKVNSRLVS
                     NIPADTRILDEENLTLLPKATKNPVEVENERIAHIRDGVAVTKFIYWLKKNVGRIPITE
                     LSAAEKLYEFRSEQEDFIDNSFDPIIAYGKHAAIVHYFATSETDIPLEPSGFLLADTGG
                     HYKEGTTDITRTVVMGPTTEEEKKYFTAVLRGTLNLGAARFLHGCTGVNLDILARQPLW
                     EMGEDFKHGTGHGVGYLLNVHEGPNSFRWKIVPGGNAVLEEGMITSDEPGYYREDGFGI
                     RHENLMVCKKAEKTEYGQFMCFEFLTMVPFDLDGVVPELMSVRERNLLNDYHAQVYEKI
                     SPYLNEEEKEWLKDATRAI"
     CDS             complement(8712..9560)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_6"
                     /sec_met_domain="ATP_bind_3 (E-value: 8.5e-08, bitscore:
                     21.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLEYLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIA
                     ITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKI
                     GDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLREAKLTKAEIREYSKELGL
                     PTWDKQSFACLSSRFVYGETISEEKLGMVEKAEQLLLDYGFHQVRVRIHGSLARIETMP
                     EEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLRGKN
                     E"
     CDS             complement(10030..10830)
                     /locus_tag="ctg94_7"
                     /transl_table=11
                     /translation="MQLKYVDTKEEIIAINRKSKHIEPHLHNALEIVCVTSGALEFGVG
                     QELYHMEKGDIGFVFPDVIHHYQVLTPGVNKATYLIASPFTIAKFSDIMQSMAPEYPII
                     KVEKVEPEVYRVINAILETEQSDITVAQAYLQIVLARCIGKLNLVEKSNVGSNDLIYQT
                     VSYISANFKKKFSLEEMAKDLGVSKYVLSRLFSKTFHRNFNQYLNDARLNYACHRLENT
                     SDSITNICLDSGFESQRTFNRVFKERYKISPSDYRSTCLKDMLS"
     CDS             complement(11182..12579)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_2"
                     /gene_functions="transport (smcogs) SMCOG1005:MFS sugar
                     transport protein (Score: 261; E-value: 5.2e-80)"
                     /gene_kind="transport"
                     /locus_tag="ctg94_8"
                     /sec_met_domain="MFS_2 (E-value: 8.4e-81, bitscore: 261.0,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEKKYLKWYNKIGYGSGDIAGNVVYAFLTSFMMVYLTDSVGLAA
                     GVVGTLIAVSKLFDGFTDIFFGSMIDKTHSKMGKAKPWMLYGYIGCAITLVCCFAIPVS
                     FGTTAKYAWFFISYTLLNGVFYTANNIAYSALTSLITKNSKERVQMGSYRFIFAFSTSL
                     LIQAITVGFVDKCGGDAAAWRTVAIIYAIIGLVINTISALSVKELPEEELNEGEVKDDN
                     EKYGMVQAFKLLVKNKYYMMICGTYILQQLYGAMIGAGIYYMTWVLKNKNLFGQFAWAV
                     NIPLIIALIFTPTLVGKWKGMYKLNLRGYVLAVIGRALVVVAGYMGSVPLMMAFTALAA
                     LGQGPWQGDMNAVIASCSEYTYLTQGKRIDGTMYSCTSLGVKIGGGIGTAVVGWMLEFS
                     GYVGTNVTQPQSALDMMQFMYLWLPLIFDVLIMFVLSRMNVEDANKKLKAEKEIAADEV
                     TDASDIN"
ORIGIN
        1 tgctgatatt ttcatcaatg cagtattagc aaattgctta agttaatgac attgggagtg
       61 aacagtaact aaaaatttac acatcagcca tatcagccgc aaacagcgcc gcgccaagtg
      121 caccgcaaag ctgagcctta tcactgatca ccagctttgt tccaagcttc tcttccagtg
      181 tctttaccag gcccttattc ttagaaacac caccggtcat catatatttc tcctcaccgc
      241 ccacacgtct gataagggcg gcagtcttta cggcaaccgc cttattcaag ccatggacaa
      301 tatcatctgt tgccttattc tgggcgatca gggatacaac ttctgattct gcaaatactg
      361 tacacatact ggaaattgta atatcttctt tgaattccag cccacattcg ctcatctgat
      421 ccagattcat ttccatggta cgtgccatca tttccagaaa tcgtccggtt cctgccgcac
      481 atttgtcatt cataacaaaa tttgcaactg caccgttctc atccagtcgg atcaccttgc
      541 tgtcctgtcc gccaatatca ataacagtac ggacttccgg attcaggaaa tgcgcacctc
      601 ttgcatgaca ggtgatctct gtgatactct tatcaccatt tttaatagct gtacgtccgt
      661 atccggtagt aaccagcgca tcaatatctt ctctctgcaa tccggcctcc ttcaatgcct
      721 ctgcaagggc acggtctgct ccgatagcag ctcctgctcc tgtaggcagg ataatgctgg
      781 tcacaatctc atgatcttta tttaaaatca ccacatctgt actggtagaa ccactgtcaa
      841 tccctgcgaa ataacctttt cccatttttc tctctccttt tgtgtctcca tctatggtct
      901 gctccagtgt ttcaggctga atgctctctg caaaagcttc cagtctggta agaagctgac
      961 cgctgctctg aatagtataa tctgattcga tttttaaaag aggtacatct gtatgattct
     1021 tgatctcagc atattcgaag ctgtaaaaat cacaaaactt cactgtatga taaataatcc
     1081 ccgcaacaga cggatcatta taaagcttct tacgacctgt cgggtccatc atacgcatac
     1141 atggaatctg tcccagaatc tcacctgcat accagtccat cagctcatca aaagaagcac
     1201 cctccggtgg aagtatattt cccacagaac ggttatgcac gcaggtatca ttctctacag
     1261 gaagaggcat agctttgctg gtcatttcaa ataattcctg ccccattctg gcgccaagca
     1321 ctgcaatatg ggactttgtg attttctcct gtgcatggaa agcagcccgg aattttccgg
     1381 catcaaactc tgtgcctttg tactgtgcat aagccttcgc cagccctttt aactgtacag
     1441 ccatacgctc tctgctgcag gcactgtcac agtgaagcac atccaaaata tagagaaaat
     1501 ccagcttgcc gctttcaagc agaatgtcat agacactccg gatagtatca cagcagctca
     1561 ccaggacaag ttccttgatt ttcccctcca tgactccttc cagaagtgtt tttccaaaac
     1621 cgcagatatt gggatgtgaa acctgatcgg ccaagtcaaa tccctccggc atatgattaa
     1681 agttctcaca ttccccgcca agagattcca gaagttcaat tggggtatat ttacagacat
     1741 agtaagtttt attcattctc agcacctccc agcatttcca gaaaagctcc cagcctggtg
     1801 gaagtctgtc cttctcctcc atggcttcga tcacacccgt caccgtccag gatcaaaagg
     1861 ggcagaccgg cttcttcgaa cttcttcttt gcaagctgtg ccgcaccaag cgtatgttta
     1921 catccccaat gtccaaacca cacagcaccg tctgctcctg cctgtttcgc atggcggata
     1981 ccggcttcaa tccttctaag ggcacttccg ttcagtgaat gatataccat tctttctgcc
     2041 attgcttcaa aggggttctc aggatcaaaa tccggctcac aggtttctgc aagttcacat
     2101 cctacaatct gggctttctc actgaagcaa agctcctggc gcactgcatc cgaccagaat
     2161 ggaatggtat gcatccagta aatgtgtttc cctttcgctg ccggtgcttt cttaatatct
     2221 tcaagaagca tctgtgtata cttctcttct tctgctgttc ccagaaggat attgtttgtc
     2281 attcctgcat acaagggtgt gaccagatca gagggcacat atctgtctgc acgcatctgc
     2341 tgatattttt tgtaattctc cagagtccgc ttactgcagg caagacgttc ctttaatctg
     2401 tcctcagaga ttgtttttcc tgtatttttt tccagaaata tttttaaatc ctttaactga
     2461 tctgccacat actgtacatt ctctgtggtc tgattccatg gtacatcaat ggcaaataca
     2521 ggtacctggt aaaaatctgc cagggtacgg aaggtgagca ggttagcatc gcaggtcagg
     2581 ttggtataaa caatacattt aggctttggc agaagtcctt tctgcgctgc accaagaaat
     2641 gtcttgtgat aactgcacag tgtctctgca attccctgat tctctgcctg ctgcagaaac
     2701 gccctctctg ctttgcttgc agaaagatag caggaaaatc cctctacatt atagggatgt
     2761 aatcccacct cctgcatcat ttcgcagggt gtaaaaatac ttacaataac agaatcttcc
     2821 ggtttctgaa tgggccgcag catggtatcc atcatcagat ttgcaagatg cctgtctgca
     2881 ggcatcaatc tcttgtcctg catataacgg aacttcagat tctgcgcctc ccagccggtt
     2941 tttaacagcc ggcgggctga ctgaggcttt ttatccgtca gattttccac ataatgacca
     3001 aatgtctcaa taatctccat agtctgtctc ttcctcatta tggtaataat aatttatcag
     3061 ttgccagcgt acaaatagcg ctacggaata ttttagtaat atcttttttt gaagtcaagc
     3121 tgaattttct ccaaagttca tctgtttttg cacattcttc ttgacaaaaa agtcttaaat
     3181 gatacacttt tgaatgtatt atttttcaaa aaaaggaagg aataatatag gaaagatttt
     3241 tacgaaagga aggaattttt aaaatgcgtt cattgacggt ttatttaaaa aactacaaaa
     3301 aagaaagcat ccttgcgcca ttttttaaat ttctggaggt tgtatttgac ctgatcgtac
     3361 ctatcgtcat tgcacagatc atagatgtag gtattgcaaa ccacgacaac ggatacattg
     3421 tccagagatt ttctattctt atactaatgg cggctcttgg tcttgccagt accatcacag
     3481 ctcagttctt tgccgctaaa gccagcgtgg gctttgccac agaattaaga caggcagttt
     3541 atgaccatgt acagcatctg tcctatacag agttggatac actgggaaca gatactctta
     3601 tcacaagact caccgatgat gtcaatcaga ttcagaacgg attaaatatg ggacttcgtc
     3661 ttcttcttcg aagtccgttt atcgtacttg gttccatggt catggcattt accattgact
     3721 ttaaatgtgc cctggttttt gctgttgcga tcccgtttct gtttctggtt gtctttgtca
     3781 ttatgtttct cagtattcct ctgtttaaaa aagtacaggg aaaactggac acagtaaccg
     3841 gactgaccag agaaaacctt acaggcgtcc gcgttatccg tgcattctgc cgcgaaaaag
     3901 aggcagttgc agaatttgat acccgcaatc aggagctgac aaagttaaat ctctttgtag
     3961 gaaagctttc cgctttatta aatccggtca cttacgtact gatcaatatt gctactgtta
     4021 ttctgatcca gaaagcagga gtagaagtaa atcttggcgg tatgcagcag ggacaggttg
     4081 ttgcccttta taactatatg gctcagatga tcgtggaact gatcaagctt gcctccctga
     4141 tcatcacctt gaacaaatct gcagcctgcg caggacgtgt ggcagatatc ctgaaagtga
     4201 aatctactat ggattacccc tcttcctcca catattctgc tcagatatcg aaggaccttg
     4261 caacagcaac tgctgatgca tcactttctg aaaatgccat cgtattcaat gacgtaacct
     4321 ttgagtacag caaagccggt gcccccagtc tttcccatat cagtttttct gtaaaaaagg
     4381 gacagaccgt aggtattatc ggtggtacag gaagcggaaa aaccactctg gtaaatctga
     4441 tctccagatt ctatgatgcc agcaaaggaa ctgttctgct ggatggtcag aatattgaaa
     4501 attacaccag aagtgatctc cgctccagaa tcggcgttgt tccacagaag gcagctcttt
     4561 tcaaaggttc tatccgggac aatctgaaat ggggccggga agatgcctct gacgaggatc
     4621 tgtggcaggc acttaccaca gcacagggaa aagaggtagt agagggtaaa ccgggacagc
     4681 ttgattttat gctggaacag aacggtaaaa acctttccgg tggccagaaa caaagactta
     4741 ccattgcccg tgccctggta aaaaaacctg aaatcctgat cctggatgac agtgccagtg
     4801 ccctggactt tgccactgat gcagcactgc gtaagtctct caacagactt gactggaaag
     4861 taactacatt tctggtatcc cagcgttcct ccagcattca gcaggcagac ctgatccttg
     4921 tccttgataa cggtactctg gcaggtaagg gtactcatgc tgaactgctg cgtacctgtg
     4981 atacttaccg ggaaatctac ttctctcagt ttccggaaga aagagccaga tactcctctg
     5041 tatctgcagg taatataatg aaggaggtga ctgtatgagc agatcaacaa taaaagatcc
     5101 tgctaaaagc aaaagcagcg aaactttttt taaagtactg cgtttcatcg gaagataccg
     5161 ttttctgctg atcctcagta tcatactggc agccgtttcc gttatccttc agctgtatgt
     5221 cccaatccta ttcggaaatg ccattgatca ggtcattgcc caacatcagg taaacttcga
     5281 aatgatgtgg tattacctgt cacgtatcct tgtaatggtc atcctctctt ctgctgccac
     5341 gtggcttatg aatgtgatca ataaccgcat gacctaccag acagtaaagg atatccgtgc
     5401 caaagccatc cgacacattc aggtacttcc cctctcttac cttgacggac acagtaccgg
     5461 agatatcatc agccgtatta tcgcagatac agatattcta tccgatggta tgctgcttgg
     5521 atttacccag cttttttccg gaatcgtaac gatcatcgga acactgatct tcatgttctc
     5581 caaaaacttc tggattacat tgatggtcat tgtcctgacc cccgtaagct ttttggtggc
     5641 caaatttatt tcttcccata ccttccagat gttccggaag caaagcgatg ccagaggacg
     5701 tcagactgct ctcatcgaag agatgattgg aaaccagaag gttgttcagg cttttggata
     5761 tgaggaaaaa tcttctgaac gctttgcaaa ggttaacgaa gaattacagg aatgcagtct
     5821 gaaggctgtt ttttacagca gcctgacaaa cccttccacc cgttttgtca ataatattat
     5881 ttatgcctgt gttgcactgg tgggtgcatt cattatccct ggaggcagac tgacagtcgg
     5941 aggactttcc gtacttctct cctatgccaa ccagtatatg aaaccattca atgatatcag
     6001 ttccgttgtt acagaacttc agaatgctct tgcctgtgca ggcagaatct tcgatctgct
     6061 ggaggaggaa ccggaagttg cagaggcttc tgagacactg aaagatgtaa agggtgaagt
     6121 agatattaag aatgtgtgct tccattatga tgaatcaaag aaactgattg aggactttaa
     6181 tctccatgta aaaccaggta tgcgcgttgc cattgtagga cctaccggat gcggtaagtc
     6241 aacctttatc aaccttctga tgagattcta tgatgtaaat tccggatcta tttccgttga
     6301 cggcaaaccg atcagagaca ttacccgcca ttctctcaga agcagctatg gtatggtgct
     6361 tcaggaaaca tggatcaaaa acggaactgt ccgcgacaat atctcgattg gaaaaccgga
     6421 agctacagat actgaaatca tcgaagcagc caagcttacc cacagctggg aatttatccg
     6481 gaggcttcct aaaggactgg acaccatgct caacgaggac agcttaagcc agggacagaa
     6541 acagctgctg tgtatcacac gagttatgct ctgtctgcct ccgatgctga tcctggatga
     6601 agctacttcc agtattgata cacgaacaga attacaaatt caggaagcgt ttgaacgaat
     6661 gatggaggga agaacaagct ttatcgtagc tcacaggctt tcaaccatcc gaaatgcaga
     6721 tctgatcctt gttatgaaag acggaagtat cattgagcag ggtactcatg atgagctgat
     6781 tgcaaaaggt ggattttacc atactttata taacagccag tttgcaaaag tttctgaata
     6841 aaacaaacca gataataaat caaaaaggaa cagctgtcca tcacggctgt tcctcttttg
     6901 attttgtaaa atgttttttt atttttatca gattgcccgg gtagcatctt tcagccattc
     6961 tttttcttct tcgttcaaat acggagaaat cttctcatat acctgtgcat ggtaatcatt
     7021 gagaaggtta cgttcccgga cactcatcag ttccggcacc actccatcca gatcaaaagg
     7081 taccatagtc agaaattcaa agcacataaa ctgaccatac tctgtttttt cagctttttt
     7141 gcagaccatc agattttcat gacggattcc aaatccatcc tctctgtaat atcccggctc
     7201 atcagaggtg atcattccct cctccagcac tgcatttcca cccggaacaa ttttccatcg
     7261 gaagctattg ggtccttcat ggacattcag aagatatcct actccatgac cggttccatg
     7321 tttaaaatcc tctcccattt cccacagcgg ctgtctcgcc agaatatcca gatttacacc
     7381 ggtacagcca tgaagaaatc tggcagctcc cagattcaga gttccccgca aaactgctgt
     7441 gaagtacttt ttctcttcct cagtagtcgg tcccatgaca acagtacggg taatatcagt
     7501 ggttccctct ttataatgtc ctcctgtatc tgccagaaga aagccggatg gttccagagg
     7561 aatatccgtt tcggatgttg caaaataatg tacaatagca gcatgctttc cataggcaat
     7621 aatcggatca aaactgttat ctatgaaatc ctcctgttcc gaacggaatt catacagctt
     7681 ttctgctgca cttaattctg tgatcggaat ccttccaaca ttcttcttta accagtatat
     7741 gaactttgta actgcaactc cgtctctgat atgcgcaatg cgttcatttt ccacctcaac
     7801 aggattcttc gttgccttgg gaagaagtgt aagattttct tcatccaaaa tccgagtgtc
     7861 tgccggaata ttgctaacca gacgactgtt gactttcttt ttgcagagaa gaactttttt
     7921 gtccttttta aatgttttca catactcata gatactgtca tagggaaaaa gggtcacacc
     7981 atctttttcc agcgcttcca gtacatctgt ctgaaaggct ttctcatttg caaaaagtct
     8041 gatctctgtt tttgtcatta caagataaga aagaaccacc ggacaacagt ggatatctcc
     8101 cccacgtata tttaacagcc aggcaatatc atccagagaa gtcagtacaa ataaatctgc
     8161 acccttcttc tccattgctt tgcggattct tgcgcattta tcagctctgg attctcctgc
     8221 ccattttata tccagctctg taaccggttc acaggaaagt accggacggt tttcccatat
     8281 atcgcctgcc agatcgtgat caacactgag agacacaccg ttttcatcca gcattttctc
     8341 caattctgct gcctcttttg cactgacagt acgtccgtca aatcccagac accttccctg
     8401 tgtcagattt tttttcagaa attcatgaac tgtgggaact tccggttcac ccattttaaa
     8461 taaagtaatt cctgttccct ccagctgatc tgcagcctgg ataaaataac gtccatccgt
     8521 ccacaatcct gccatatcct gcatgatcac cgcagtgcct gcagaaccgg taaatcctgt
     8581 gatatatttt ctgcatttga aatattcacc tacatattcc gaaccatgga aatcatctgt
     8641 agggatcaga tatgcatcaa ttcctgtctc tttcatgcgt gcacgaagtg ctgttattct
     8701 ctcttttact gtcattcgtt tttaccccta aggctgctat ctgcagtcgt tttgtcattt
     8761 tcgccaagtg tttcgttcat acttcccata cgatatccca gaatatccat ggtcacataa
     8821 gtgaatccat actccttaaa tttctttgca atatcctctc ggacattttt ttccagaagt
     8881 ttcggaaatt cctccggcat agtctcaatt cttgcaagtg aaccgtgaat acggacacgt
     8941 acctgatgga atccatagtc aagtaaaagc tgctctgctt tctcaaccat tccaagcttt
     9001 tcctcactga tggtctctcc atagacaaac ctggaggaca gacaggcaaa tgactgtttg
     9061 tcccaagtcg gaagccccag ttcctttgag tattctctga tctccgcttt cgtcagcttc
     9121 gcctcacgta gcgggctctt aactccaagt tcttttacgg cgatcagacc tggtctgtaa
     9181 tcgccgttat catccatatt tgatccctct gcaatatatt caatcccatt cttttttgca
     9241 atatcgccaa tcttctcaaa cagttctttt ttacataaat aacatctgtt cggaggattc
     9301 tttgaaaatc cttcaatctc caattcctca gactggcaga tcacatgctg aatcccctct
     9361 ttctcgcaga atgccttcgc ttcattcagc tctcttttcg ggaaagaaca ggattgagcc
     9421 gtaatcgcaa tcgccttatc acccagcaca tcatgagcta cttttaataa gaatgtagaa
     9481 tccactccac ttgagaaagc aactgctaca ctgccaagtc ccttcagata ttcttttaaa
     9541 tattccagtt tattttccat atcagtctgc ctcttgtccg ttttttattg tacctgtagc
     9601 actcctcgta aataatgtat attgatctgg ctcaacagag cgtgaaagtt gaactttctc
     9661 aaatgtatta tttaacaggg tgctatagct tcattataat ataggcaatg actgttcagc
     9721 aacctatttt tcgcattgcg aaatgtgtta ctgaaaatag aacgaacaat attgatttat
     9781 gtttcttgta tcttttctaa cgcttccccg acttctgtta cttctttaaa tagtttctaa
     9841 agtaacagcc tctcttaact tctttattta cagtttgtct acttcttttt ctgaagcagt
     9901 tctccgtttg tttcttcccc attcatacat gacataataa ttaaccacta ccccatatta
     9961 taaataacac ccagagatac ttatttcaga ctgataatca gatttttatt gaatttatta
    10021 atctatatgt tatgacaaca tatctttcag acatgtactc cggtagtcac tcggtgatat
    10081 tttatatctt tctttaaata ctcggttaaa tgttctctga ctttcaaatc cactatccag
    10141 acaaatgttt gtaatagaat cactcgtatt ttccaaacga tggcatgcat agttcagcct
    10201 tgcatcgtta agatattgat taaagtttct atggaatgtt ttggaaaaga gtctggataa
    10261 aacatatttg ctcaccccca gatcttttgc catctcttcc agagaaaact tcttcttaaa
    10321 atttgctgat atataggaaa ctgtctggta aataagatcg ttgctcccca cattactctt
    10381 ttctaccaaa tttaattttc ctatgcagcg tgccaacaca atttgaagat atgcctgtgc
    10441 aacagtaata tccgactgtt ctgtctctaa aattgcattt ataactctat atacctccgg
    10501 ttcaaccttt tccactttga tgattgggta ttcaggagcc atggattgca tgatatctga
    10561 aaatttggct atcgtaaatg gcgatgcaat cagataagtc gctttattta caccgggtgt
    10621 cagtacctga tagtgatgaa taacatctgg aaatacaaag cctatatctc ctttttccat
    10681 atggtatagt tcctgtccga caccaaattc taatgctcca cttgttacac aaacgatctc
    10741 cagtgcatta tgaagatgtg gttcaatatg ttttgacttc ctatttattg ctatgatctc
    10801 ctcttttgtg tcaacatatt ttaactgcat gaaatactcc cctttgcaac atttgtctat
    10861 atcttctttc gatttggcaa gcaatccttt tacacctatc ttataatcaa cttgtaaata
    10921 aggaaaggag gaattgcaaa tgagcaacct aaaaaaatat ctgaatgacc ttttagtatt
    10981 ctacactgaa tattttgagc atccttacca tgtataaata ctaaaaggac tattttgtga
    11041 aaactgaata ttttcttaag gccatttcac aaaaatgaag tggtcctttt ttattttcaa
    11101 aatacagttc aatcacttta tatatagaaa aaagcactgt ctcatcgagc aatgaccaga
    11161 caacgctttc tcctgtcaat tctaatttat gtccgatgca tctgttactt catctgcagc
    11221 aatttctttt tctgctttca gttttttatt tgcatcttct acattcattc ttgaaagtac
    11281 aaacataatc aatacatcaa agattaacgg aagccaaaga tacataaact gcatcatatc
    11341 aagtgcagac tgcggctgag ttacatttgt tccgacatat ccactgaact caagcatcca
    11401 tccaacaaca gcggttccaa tacctccacc gatttttacg ccaagagaag tacaagagta
    11461 catcgttccg tcaattctct ttccctgtgt aagataagtg tattcagagc aggatgcgat
    11521 aactgcattc atatctccct gccatggtcc ctgacctaag gctgcaagag ctgtaaacgc
    11581 catcatcagc ggaacactgc ccatatatcc tgcaacaaca acaagtgctc taccgatgac
    11641 tgctaagaca taacctctta agttcagttt atacatacct ttccacttac caactaatgt
    11701 cggtgtgaaa atcagggcaa tgatcagtgg aatatttact gcccatgcaa attgtccaaa
    11761 caaattctta tttttcagta cccatgtcat gtaataaatg ccagctccaa tcatggcacc
    11821 atataactgc tgtaaaatat atgttccaca aatcatcatg taatatttgt ttttaacaag
    11881 aagcttgaat gcctgtacca ttccgtactt ttcattatca tcctttactt ctccttcgtt
    11941 aagttcttcc tcaggaagtt ccttaacaga aagtgctgaa atcgtattta tgacaagacc
    12001 aatgattgca tagataatag caaccgttct ccatgccgca gcatctccac cacatttatc
    12061 tacaaatcca actgtaatcg cctgaatcag aagacttgtt gaaaatgcaa aaataaaacg
    12121 gtaagatccc atctgcacac gctctttgct gttctttgta atcagtgacg taagtgctga
    12181 gtaagcaata ttgtttgctg tataaaacac accatttaac agtgtataag agataaagaa
    12241 ccatgcgtat ttagccgttg ttccaaagct gactggtatt gcaaagcagc agaccagcgt
    12301 aatggcacaa ccaatgtatc cgtatagcat ccatggcttc gcttttccca ttttactgtg
    12361 tgttttgtca atcattgatc caaaaaatat atccgtaaaa ccatcaaata gttttgatac
    12421 ggcaatcagg gtacctacga cacctgcagc aagtcctact gagtccgtca gatagaccat
    12481 catgaaagat gtcaggaagg catagactac attacctgca atatcacctg atccatatcc
    12541 aattttgtta taccatttca aatacttttt ttcttccatc gaatttcttt gctcctcatc
    12601 ttcatcgcac ttagaatctc aatatgtcta accgtatgat gtctaattat atttttttct
    12661 ctgtttttgt ctgattgctc tgtatatccg gactttacat aacaatcaga ctctctttcc
    12721 ttgtttacgg gttacatgaa actttattat ccctttacat acggtatcag cgtaaactgg
    12781 aaccggaata atacatcatc aaatcggtac tgatccaata caactggacc acaactatta
    12841 gaaccaatgc catttaatgc gtagtcaacg caaaatacta cactatctga ttctgtcagt
    12901 tcataattat gcgttttctt ctcaagttct tcctgtgtat aataagaagc attgaatgag
    12961 aaggcatttt ccgcagatac cacaattcca tatcggctgt tgttaagctc tacatattca
//
