LOCUS       gnlProkkaDJOOHGHI_98   15051 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DJOOHGHI_98.
ACCESSION   gnlProkkaDJOOHGHI_98
VERSION     gnlProkkaDJOOHGHI_98
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 08:20:58
            Original ID  :: gnl|Prokka|DJOOHGHI_98
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 23781
            Orig. end    :: 38832
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15051
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10788]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10788
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15051
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15051
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             1504..2109
                     /locus_tag="ctg53_26"
                     /transl_table=11
                     /translation="MAKFRLGKAWDFNLEITNSLLDDSFDGWEGEGSNDRWDGHVNILA
                     GVSYRFKNHNGSRQFTYARHDMSKYDEANAEINRLREANKAAAPPVTKIETEVVESNHI
                     RSFISFDNASAAINKLQEVNVYTAAENIKKLADGDLYITSTKEVRDTELFMARAQSIRN
                     VLANTYDIPAGRIFIEKNPAVIASLDPQKSCVIVYINE"
     CDS             2162..3364
                     /locus_tag="ctg53_27"
                     /transl_table=11
                     /translation="MVFFCSVSLWAQTIEDDATWKLKTDTVRALKHYKAGDNWFIGIQA
                     GANHSLSENSRFGSFGTMTRPSIALSVGKYFSPAIGARVQLAYLKQMSRANSEVIEAFP
                     EVYGKGNYGFNMFNGYLDGLFNLHNIFAQYDEDIRFNVVGILGMGFNSSFGFDDKVKEW
                     DKSPSEEFAPYQISTDNKTFFSLRAGLQFNYMLSNALDINLEATFNATDDAFNGTRYDR
                     KWDSYANVMLGLTYHFKDQYGDRRFRYTEVNDQAWVDELNRKINEERNKPIPAPVVTEV
                     KKEVVKNEMLGMTVSFIIDKYNITDIQKKNVAEAAKYLEDHPEVNLIITGYADVQTGNP
                     AYNLKLSQRRAEAVCNMMVKEFGVDPSRIRVDYKGDSLQPYQLKNEWNRVVVFITEARN
                     K"
     CDS             3385..4530
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-168). E-value:
                     2.9e-09. Score: 28.3. Matches aSDomain:
                     nrpspksdomains_ctg53_28_Aminotran_1_2.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     314.6; E-value: 1.6e-95)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_28"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.7e-100,
                     bitscore: 325.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.2e-09, bitscore:
                     28.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIWLSLAHMGGSEQEFVREALETNWVVPLGPNVDGFEHDLSQW
                     LSTHCDQEVHAVALSSGTAAIHLALIMLGVSKGDEVICQSFTFAASANPICYQGATPIF
                     VDSEPDTWNMDPILLEQAICDRMKQTGLKPKAILPVHLYGTPARMNEICDIASRYGIPV
                     VEDAAEAMGAVYDGRYCGTFGQYGIFSFNGNKMITTSGGGALLCHTEEEAQRVKFYATQ
                     AREPFPWYQHEQIGYNYRLSNVSAGIGRGQMRVVDNHIAHRRAIHRLYTELLAGLPGIT
                     VVEPKKSTMFLPNYWLTTIKVDSNETSFSALQLMQHLAKADIETRPLWKPLHLQPVFSS
                     SPTYVNGVSEALFNCGLCLPSGSMMTCEDVMRVADAIRSMR"
     aSDomain        3496..3888
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_28_Aminotran_1_2.1"
                     /evalue="2.90E-09"
                     /label="ctg53_28_Aminotran_1_2.1"
                     /locus_tag="ctg53_28"
                     /protein_end="168"
                     /protein_start="37"
                     /score="28.3"
                     /tool="antismash"
                     /translation="FEHDLSQWLSTHCDQEVHAVALSSGTAAIHLALIMLGVSKGDEVI
                     CQSFTFAASANPICYQGATPIFVDSEPDTWNMDPILLEQAICDRMKQTGLKPKAILPVH
                     LYGTPARMNEICDIASRYGIPVVEDAA"
     CDS             4831..5220
                     /locus_tag="ctg53_29"
                     /transl_table=11
                     /translation="MTKKVYTKPELKSEAFVPQTHVAACGDSGTVYKFTCDAPRGTLYY
                     FRDKPASGSQPTIGNRGIWLGNYHPCSAFHEAEAQSGFYWGYVDYNHNQIFEKSELVIV
                     WRGQKGWEGHATKNLDINSWETAKS"
     CDS             5585..5956
                     /locus_tag="ctg53_30"
                     /transl_table=11
                     /translation="MLISEEFIPNEYVAACYNFKALFHCHYGENNTNNHGEPCATTYVD
                     INGIHATGHEGTIEKWGIPILNIDWNGFDLSDAKVGDKIRGIKWTSYDTVNNTGEYNHQ
                     GWGEIRSAVEEIPGRPNHS"
     CDS             6412..7515
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_31"
                     /sec_met_domain="PF04055 (E-value: 2.1e-30, bitscore: 97.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLQDINPVERALVNKATANRTPINATIELTPTCNFRCDMCYIR
                     MEKSQAEKRGGLRSIEEWLHIADQLQEIGTLFILLTGGEPLLYPDFKELYIRLKEKGFI
                     LTINTNATLIDDETVRLFQRLKPRRVNVSLYGVTNGTYLNLCHATNGFDRCLEGLKRLK
                     EYGIDTKLNLTLTRQNIKEHRQMLELADEWDLPMLTNSYISVYSRPGCATTLPLDTCRP
                     VPDEVAHAEVEALEHKYGKEYTSYATHVLQQLERGESPVPAEGIGLACRAGKSSAWINW
                     QGVMTPCVDMETPAVSLLSTTVSDAWKQIVTKCEQLPFHKECAGCTLRSICDVCYANAR
                     NEKEQCGGIGYLCRIAKSKKKQMKGSL"
     CDS             complement(7461..7991)
                     /locus_tag="ctg53_32"
                     /transl_table=11
                     /translation="MAQASVSFSAVSIQGDVYPPRLVGLQDAYHFVVDECAVRIESQDE
                     SHFAQPGVQLLEVWIEHRFTSGEKDEECTHVLKLFCPVEPLLQRRQTSVPFHHAAFGAY
                     EAHVAVERTGGSQLEVGSDRDTALIGFVHQCPFQKVGIVKMIHNLECICIYEKSLYRLP
                     FICFFLLFAMRQR"
     CDS             8016..8657
                     /locus_tag="ctg53_33"
                     /transl_table=11
                     /translation="MEALKRLKKADIDVKLNVSIVRKNEKDYDEIIRLAQHLDIPAEVN
                     SYMFPLSRPECGSLRNILTERLDADEAARIEMQYMEYKKGNDMARYMHDLKYTLAHVEG
                     TRACSLECRAAKSSCWINWQGILTPCVMLDQPAVDLKKIPMTTAWQQLLEEAKELVSHT
                     ECEGCHLRPVCNVCYAAAHCEKTITGSMDYLCQMAKAKERIITNYPPVIH"
     CDS             complement(8706..9002)
                     /locus_tag="ctg53_34"
                     /transl_table=11
                     /translation="MQFSFQTFDEIDVGISFVSFLIESIAGIQVSYSQQACFLFFLPEN
                     YDVVALECDLPVVGRQRQTVDKIECIVPVRFFGSGFMVEKQTAVNRNLLFCHS"
     CDS             complement(9108..9848)
                     /locus_tag="ctg53_35"
                     /transl_table=11
                     /translation="MNWTFDDSLGVTDKIIFFIFNIINTVHDIFTVASLIEHHISFPKF
                     TGGAFQADVVSCVDQEWSHAAARDDHAHLLSFLNEGTQHGYVFFRIDSLHNGAYFTLSD
                     NFQFGQIPVQGEGCFRIHVARIGADACLSGQNLQIVECFAGELWIPPVDCNLRAESFEM
                     LHGCLGTDGVIRCLFDEYNGLQRAAFIVTDTAGTAYRPSRYLVVAVWKWTEQGTVAIEY
                     LGAGNMPAPQVGMRRFANAARTTE"
     CDS             10001..10282
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_36"
                     /sec_met_domain="PF05402 (E-value: 4.9e-17, bitscore: 53.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-14,
                     bitscore: 45.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTKEFIKRNIAGEIVLVPSGQTAREFNGMVTLTETGEFIWEHI
                     EEAESFNHLVLLILEEYEVDKDTASQDAAGFIMQLLQAGMIRPTGINW"
     CDS             10519..10788
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_37"
                     /sec_met_domain="PF05402 (E-value: 1.6e-17, bitscore: 55.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.6e-10,
                     bitscore: 30.2, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLNSNLILRQVGGEYMIVNPFSETMDMAQVYSLNETAAWLWKQL
                     ENKEFTVDEAGALLCNEYEVNKDTARNDANELCRQWLETGLAIE"
     CDS             10828..11880
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_38"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.4e-34, bitscore:
                     111.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLLRQGLWDRQEDCSALFPLDEKEWNEIHSMARKQTVQGIIYDG
                     IRLLPTEAVPPRKVLLGWMVEVDTLERVNRQHRETIKALQQIYVQSPSIPFLLLKGIGT
                     ADFYPHPEHRIAGDIDLWFGNKTQTEQANQRMEKLGLPVKRGTNGEASCLINRVLIEHH
                     SRLIELHNPFLQKEIRQWEAGVFTNSQGKLPSEANHLLLSTHILKHLINEGIGLRQLCD
                     IAMAFNALHSVTNKNELECICRKWHIHRWNRLLYALLIKYLGVPADLLPFSTSLCPDKL
                     MQEIWESGNFGHGDERYGERPTGKWANKRYTLKRIFHKTHLSLGYAFDETFWWLAGLAL
                     LRFKEMIKKK"
     CDS             11936..12310
                     /locus_tag="ctg53_39"
                     /transl_table=11
                     /translation="MSVRMESFQMGYAGNRRIPLAHHLLYLFGYFRSGHVIGQCGHVQM
                     DHRCSYRSTGREYLPGSHNSSLILPAGYGDKTCISLDFWQDQHAHQYPHAKFAVRRPND
                     VFMERSREMAHRRPADPYQQ"
     CDS             12522..13565
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 175; E-value: 4.4e-53)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_40"
                     /transl_table=11
                     /translation="MGTVMQENLSKRILVRSLGATNYRKQKLHETQEKLFKLGMEQIKF
                     STFTQGVMGFTFGGGYLCAFLWGIFQLHNHEITFGTMTAFLQLVGQVQGPFLGLISIPP
                     SLIRGWTSVERLMALFEDVEPDEHPVYIDQPLTLNFRKVSFGYEEGQPVLDRFTAAFHP
                     GSSTAIAGPTGTGKTTIIRLILALVYPEKGRIDLTTDDGRTLSVTPDLRINFVYVPQGN
                     TLLSGTIRENLWLGSPGADEEALHKVIRLACAEFVFSLPEGLDTKIGEHGYGLSEGQAQ
                     RIAIARALLRPGRIWLFDEASSALDTETTTHLMDNLLQWGKNNTLIFVTHDSRLMERCD
                     QVIHIKE"
     CDS             13587..14396
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 72.7;
                     E-value: 3.7e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg53_41"
                     /sec_met_domain="Poly_export (E-value: 1.4e-13, bitscore:
                     42.2, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTIKLACLLAIIIFSSCASRKDFVYLQDMDELQEYPMVQKYEA
                     IIHRDDRLSIIVNSKNPELSLPFNMSGSRSYSVEADGSISNNEVGVLSDEKEKGYLVDI
                     NGNIDFPVLGQLHVEGLTRRQLTELIKKRLINEELLKDPMVTVNFLNFKFSVLGEVGHV
                     GTFEVKGDRITLLEALAMAGDLTPRSRLDRIAVIREYGNKRRILFHDIRSKDIFTSPYY
                     YLQQNDIVYVEPTNMKATEQAQRKLSTWSMILSFITTITSLVLLTTK"
     CDS             14436..15005
                     /locus_tag="ctg53_42"
                     /transl_table=11
                     /translation="MSGDKTLSGGGFNINPVDIIMYLLSKWYWFVLSVSLFGGYAWYQY
                     AKLPFIYSRSATVMIKDAYSNNIGRGLDRFNTYSYTNVSNEILQFQSHKLMRDVVNRLH
                     ANVCYLIMDDLREEELYTQAPVKVSFPEEEDHLDFSLTVRIQNRKQVRLSDFSTDATSI
                     TLTANLGDTIQSPIGKIVVSPTLYYR"
ORIGIN
        1 ccatcctgcc tatcataggt gatgtacgca accgtgaccg tgtggagtcg cagacaagac
       61 tctaccaccc cgacatcatc tttcatgcag ccgcatacaa acatgtaccc atgatggaaa
      121 aatatccatg cgaggcggta cgtaccaatg tcctgggtac aagcatcatg gcagatacgg
      181 cattgaaata tggcgtaaag aaattcatca tgatctccac agacaaagct gtaaatccca
      241 gcagtgtgat gggtgctacc aaacgactgg cagagatgta cgtacaaagc ctcgggagtg
      301 ctatccaaga aggaaatata attggtaaaa cctcttttat aaccacccgt ttcggcaatg
      361 tgctgggcag caacggcagt gtaatccccc ttttccgcca acagattatg gaaggggggc
      421 ctgtaacagt cacgcatccg gacatcatcc gttatttcat gactattccc gaagcttgcc
      481 gactggttct agaggccgct tttatgggac aaggaaacga tatctttatt ttcgacatgg
      541 gtaaacccgt aaaaataacc gacatggcat gccggatgat aaaactggca ggtttacaac
      601 cggacaaaga cattgaaatc gtctataccg gtctgcgacc gggcgagaaa ctatatgagg
      661 aattactcta taatgaagag aactctactc ctacccttaa tccgaaaata ttcaaaggta
      721 tcagtttaaa acaagattac gataaaataa agcccgccct gcaacaattg gttgaggttg
      781 cccagacgga caataaaaaa gagaccgtat atcagttgaa gcaaattgta ccggagttca
      841 aaagtatgaa ctccgtatat gaggcgctgg atgaaaaaac atatatatcc aaaaaaatga
      901 aatccaatat aatgtttaac taaaatgaat cgcaaaatga aaaaacattt cattgcgttt
      961 atgatgccat ttctaacctt ggctacggga tttgcacaag aagcggctca agatgttcct
     1021 gtcaaacagg atacaaagga gatctcttac tggacagacc ctgcaagcgg ggacaaacgg
     1081 ctcttaaaca agtctaaatt cagagacaac tggtttgtcg gattgcaggc cggcgccttt
     1141 tattcctggg ggacccatac ttccagttct ggattcttcg accagttccg tcccgccggt
     1201 gcgttgtcca taggcaagtg gatcgctcct gccggaggta tccgcctcca aggtttctat
     1261 ggaagcaatg ccggacgagc aagcaacgac aagccctact attgggacgc catgggggta
     1321 ggcctagacg gattgttcaa cttcaccaac ctcttttgcg ggtatgaaga agaccggacc
     1381 ttcaacctga tcggtatctt gggagccggt tacgaacaca ccgccaactt cagcaagcgt
     1441 acctggaacg acggaatata caataccgaa tcgcaagacc tgctgtccat ccgcctgggt
     1501 ctgatggcga aattccgcct cggtaaagcg tgggacttta atcttgaaat cacgaacagt
     1561 ttgcttgacg actcattcga cggttgggaa ggcgaaggtt caaacgaccg ctgggatggc
     1621 catgtcaaca tattggcagg tgtcagctac cgtttcaaaa atcataacgg ctcacggcaa
     1681 ttcacctacg cccgccacga catgtcgaaa tatgacgaag caaacgccga aatcaaccgc
     1741 ctgcgtgaag ccaacaaagc ggcagctcct cctgtcacaa agattgagac agaagtggtg
     1801 gaaagcaatc atatccgttc gtttatctcg tttgacaatg cttccgccgc aatcaacaaa
     1861 ctacaggaag taaacgttta cacagcagca gaaaatataa agaagctagc cgatggcgac
     1921 ctctatatca cttcaaccaa agaagtaaga gacaccgaat tgttcatggc acgggcacaa
     1981 tccatccgca atgtgctagc caacacatac gacattccgg ccggacgtat ttttatagag
     2041 aaaaaccctg ctgtcattgc atcgctcgat ccacaaaaga gctgcgtcat agtgtacatc
     2101 aatgaataaa cgacccattt taaaagtata atttggcatg aaaaaaatag ctatattatt
     2161 tgtggtcttc ttttgttctg tatctttatg ggcacaaaca atagaagacg atgcaacttg
     2221 gaaattaaag accgacactg tacgggcgct aaagcattac aaggccggtg acaactggtt
     2281 catcggaatt caggccggcg ccaatcattc gctgtccgag aacagccgct tcggatcttt
     2341 cggcaccatg accagaccaa gcatagccct ctcggtcggt aaatacttct cacccgccat
     2401 cggagcacgt gtgcaactcg cttatttgaa acaaatgtca cgcgccaaca gcgaagtgat
     2461 tgaagccttt cccgaggtgt atggcaaagg gaactacggt ttcaatatgt tcaacggtta
     2521 tttggacgga ttgttcaacc tgcacaatat tttcgcccaa tatgacgaag atatccgttt
     2581 caatgtagta ggtatcttgg gtatgggatt caactccagt ttcggattcg atgataaagt
     2641 caaagagtgg gacaaatccc ccagtgagga gtttgccccc taccaaatca gcactgacaa
     2701 caaaacgttt ttctctctac gcgcaggcct ccagttcaat tatatgttga gcaatgcgct
     2761 tgacatcaat ctggaagcga ccttcaacgc aacggacgat gctttcaacg gtacgcgtta
     2821 cgaccgcaaa tgggattcat acgccaacgt catgttaggt ctcacctatc atttcaagga
     2881 ccagtacggc gatcgccgct tccgctacac agaggtgaac gaccaggcat gggttgacga
     2941 attgaaccgc aagatcaatg aagagcgtaa caagccgata ccggcaccag tcgtcacaga
     3001 agtgaagaaa gaggtagtga agaacgaaat gttgggtatg accgtatcat tcattatcga
     3061 caagtacaat attaccgata tccagaaaaa gaatgtggca gaagctgcca agtatttgga
     3121 agaccatccg gaagtcaacc tgatcataac aggttatgcc gacgtacaga ctggtaatcc
     3181 ggcctacaat ttgaaattga gccagcgccg tgccgaagct gtctgcaaca tgatggtgaa
     3241 agagttcggt gtggatccaa gccgcatccg ggtggattac aaaggtgata gcctgcaacc
     3301 ataccagctg aagaacgagt ggaaccgtgt tgtagtgttc atcaccgaag cacgcaacaa
     3361 ataatttttt gttcataact gaaaatgagt aagatttggt tgtcattggc acacatgggc
     3421 ggatccgaac aagagttcgt ccgtgaggct ctcgaaacca attgggtagt tcccttaggg
     3481 ccgaatgtag atggcttcga gcatgacttg tcacagtggc tttcaacgca ttgcgaccag
     3541 gaggtacacg ccgtggcatt atcatcaggt acggcagcca tccacttggc attgatcatg
     3601 ctgggcgtaa gcaaaggaga cgaagtgatc tgccaaagtt tcacctttgc tgcgtcagcc
     3661 aaccccattt gttatcaggg tgctaccccc attttcgtag acagtgagcc tgatacttgg
     3721 aatatggatc ctatactgct tgaacaggcc atctgcgacc gtatgaaaca gaccggcctc
     3781 aagcccaaag ccattcttcc agtacacctt tacggcacgc ctgcccgcat gaacgaaatc
     3841 tgtgacattg cctcccgcta cggcatcccc gtggtggaag acgctgccga agcaatgggg
     3901 gccgtttacg acggacgcta ttgcgggacc ttcggtcaat atgggatttt ctcttttaac
     3961 ggcaacaaga tgatcaccac cagcggtggc ggcgccttat tatgccatac ggaagaggaa
     4021 gcccagagag tgaagttcta tgctacccag gcacgtgaac cgttcccctg gtaccagcac
     4081 gaacagatcg gatacaatta ccggctcagc aatgtgtcgg ctggtatcgg acgcgggcag
     4141 atgcgtgtag tggacaacca tatcgcacac cgccgtgcca tccaccggct atacaccgag
     4201 ctgctggcag gacttccggg tatcactgtg gtagaaccca agaaatctac catgtttcta
     4261 cccaattatt ggctgactac aattaaagtg gacagtaacg aaaccagttt cagcgccttg
     4321 cagctgatgc agcacttggc aaaagccgac atcgagaccc gtccgctttg gaaaccgtta
     4381 cacctgcaac ccgtattctc atcctccccc acctacgtca acggagtatc ggaagccctg
     4441 ttcaactgtg gactctgtct gccttcggga tcaatgatga cgtgcgagga tgtgatgcgt
     4501 gtagcggatg cgatacggag tatgagatag ataatttatt taataacaga cagagttctg
     4561 caagaacttg gctatatgaa agtttcatag taaagagaaa attgtaagat gttaggaatt
     4621 tggagatgga acgtgaacaa gccgaaagcg acatgtcaca tccggatatt tatctccgta
     4681 aatcggtaaa gactgtaaat cacagtcgtt tcatcctttt tattcttgat tcttattgat
     4741 tgagttcttg cagaactcgg tcatgttttt ctcttttcaa acttttgccc tcttacagaa
     4801 taagaagtct ggcaaaacaa gaaaaaaaag atgacaaaga aagtttatac aaagccggag
     4861 ctgaaaagcg aggctttcgt gccgcaaacg catgtggctg cttgtggaga tagtggaact
     4921 gtttataagt ttacttgtga tgcaccaaga ggaacgttgt attattttag agataagcct
     4981 gcttctggtt cacaacccac tataggaaat cgaggtattt ggctaggaaa ctatcatcca
     5041 tgtagtgcat ttcatgaagc cgaagcccaa tctggttttt attggggata tgttgattac
     5101 aaccataatc agatatttga gaaaagtgaa ttagtcattg tttggagagg acaaaagggc
     5161 tgggagggtc acgccaccaa gaaccttgac ataaattctt gggaaactgc taaatcctaa
     5221 tcggtaaata aaacagtaaa tagcaatctt attcatttat ttcaatcttg attcctaacg
     5281 cttagataaa tttattgatt ctcattaata gaaatagaga ttaaataata tatgatcaga
     5341 ctactggagg aactaagtca gaatatcgtt tgagctgcaa agaattagtg taatgaaaag
     5401 gaaaatgaaa ggatcatatt gtagatggta aatcgcaata tatcaattat ttcaaaattc
     5461 tttcacaccg gagtttctcc gggacccaat cactatttcg cttcaaacct tttctgattt
     5521 cctttcctcc gaaacaggaa tcaaaaaaga aaaaaatagt atgaagaaag attatcaaaa
     5581 accgatgctt attagcgaag agttcattcc gaacgaatat gtagctgcat gctataactt
     5641 taaagcacta tttcattgtc attatggaga aaacaataca aacaatcatg gagaaccatg
     5701 cgctacaacc tatgtagata ttaatggtat ccatgctaca gggcacgaag ggactataga
     5761 aaaatggggt atacctattc tcaatattga ttggaatgga ttcgatttaa gtgacgcaaa
     5821 agtaggtgac aagattagag gcatcaagtg gactagctat gatacagtaa ataacactgg
     5881 agaatacaat catcaaggtt ggggtgaaat cagatctgct gttgaagaaa taccaggtcg
     5941 tcctaaccac tcttaagaca ttcccctatt tatgaaattc gcatcaaata acagtataga
     6001 cttggacctt aaaagtaaag tctatactgt aaacctctca aattagggtt ctaaaatatc
     6061 tatcttcgct gcgaatcaaa atttacgaat tatgcaaagc aatgaagacc ttgaaagatt
     6121 ctactttccc tatctttggg tctatcatcg taaaatatag acttggttgt atgccaatag
     6181 ttaaaaatca atcgaatttg ataatatctt tttgtgagat gccaattctg gtgccttata
     6241 aaaaggatat gctctaaatt aagtattaac ttttgttgag cttcaaaaag ggaagataat
     6301 ctatatattt tccatcgaga caaatttcgg taacatatac gaccacggaa gtaaatgaaa
     6361 tccaatacac tagactcaaa aacttttctt tgaaaaaaaa tcattatcct agtggaatcc
     6421 ctgcaagaca taaaccctgt ggaacgggca ttggtgaaca aagcgacggc aaaccgtact
     6481 ccgatcaatg ccactattga attgacaccg acgtgcaatt tccgttgtga tatgtgctat
     6541 atccgcatgg agaagtcaca agccgagaaa agaggaggat tacggagcat agaggaatgg
     6601 ctgcacattg ccgaccagct acaggaaata ggaacgctct tcatcttact gacaggaggc
     6661 gagcccctac tctatcctga tttcaaagaa ttatatatcc ggctgaaaga aaaaggattc
     6721 atcctcacca tcaatacaaa cgcgactttg atagatgacg aaacagtacg tctgtttcaa
     6781 cgtttgaaac cccggagggt gaatgtctcg ttatatggtg tgaccaacgg aacttatctc
     6841 aatctgtgcc acgcgacaaa cggtttcgac cgttgcctgg aaggactgaa acgattaaaa
     6901 gaatatggca tagataccaa actgaacctc accttgacac gacaaaatat aaaagaacac
     6961 cggcaaatgc tggaactagc tgacgaatgg gacttaccta tgctgaccaa cagttacatt
     7021 tcagtctatt cacggccggg atgcgccacc acgctacccc ttgatacgtg ccgccccgta
     7081 ccggatgaag tggcacatgc cgaggttgag gcactggaac ataaatatgg caaggaatac
     7141 acatcatacg ccactcatgt cctccagcaa ttggaacgtg gagaatctcc cgtacctgct
     7201 gaaggcatcg gacttgcctg ccgggcaggt aaaagttccg catggatcaa ctggcagggc
     7261 gtcatgactc cgtgcgtcga tatggaaaca ccagccgttt cgctactttc cacaaccgta
     7321 agcgatgcct ggaaacaaat agtaaccaaa tgcgaacaac ttccgttcca taaagaatgc
     7381 gcaggttgta ccttacgctc tatctgtgat gtctgctatg ccaatgcccg caatgaaaaa
     7441 gagcaatgcg gcggcatcgg ctacctttgc cgcattgcaa aaagtaaaaa gaaacaaatg
     7501 aaaggaagtc tataaagact tttctcataa atacatatac attccaagtt atggatcatc
     7561 ttcacgatgc caaccttttg gaacgggcat tggtggacaa agccaatcag agccgtgtcc
     7621 cgatcactac caacttcgag ctgactccca cctgtacgct caactgcgac atgtgcttca
     7681 tacgcaccga acgcagcgtg gtggaacggc acggaggttt gtcgcctttg caacaatggc
     7741 tcgactgggc agaacaactt caagacatgg gtacactctt catccttctc accggaggtg
     7801 aaccgatgct ctatccacac ttcaaggagc tgtacacccg gctgcgcgaa atgggattca
     7861 tcctgactct caatacgaac ggcacactca tcgacaacga aatggtacgc atcttgcaga
     7921 cccacaagcc gcggcggata aacgtcaccc tgtatggaga cagcagagaa acttacggac
     7981 gcttgtgcca caatccgcaa ggatacaccc tgtgcatgga agccctgaaa cggttgaaaa
     8041 aggcagacat tgatgtgaaa ctgaacgtaa gtatcgtacg aaagaatgaa aaagattacg
     8101 acgagatcat ccgtctggcc cagcatctgg acattccggc agaagtaaac tcatacatgt
     8161 ttcctctctc acgccccgaa tgcggaagtc tgcgtaacat tctaactgaa agactggatg
     8221 ccgacgaggc ggcccgcatc gagatgcaat atatggagta caaaaaaggg aatgacatgg
     8281 cacgatacat gcacgacttg aaatatacgc ttgcccatgt ggaaggaaca cgagcctgct
     8341 ctttggagtg cagagctgcc aagagttcat gctggatcaa ctggcaaggc atcctcaccc
     8401 cctgtgtgat gctggatcaa ccggccgttg acctgaaaaa gattccgatg acaactgcat
     8461 ggcaacaact tttagaagaa gccaaggaac tggtatccca taccgaatgc gagggttgcc
     8521 accttcgtcc cgtatgcaac gtatgctatg ccgccgcaca ctgtgaaaaa acaatcaccg
     8581 gaagcatgga ctatctttgc cagatggcga aagccaaaga acggatcatt acgaattatc
     8641 cccccgtaat acattaaaaa ctgaagattg tgagactgaa tatcggcccg ctaacgattg
     8701 aattgtcagg agtgacagaa caggagattc ctgttaacag ccgtttgttt ctcgaccata
     8761 aacccgctac caaagaagcg gaccggtact atacattcta ttttgtcaac cgtctgcctt
     8821 tgccgtccaa cgactggcag atcacattcc aacgcaacga catcgtagtt ttccggaagg
     8881 aagaacaaga aacacgcctg ctggctgtag gaaacctgaa tgcctgctat gctctctatc
     8941 aggaaagaaa cgaaagagat gccaacatct atttcatcga aggtctgaaa agagaactgc
     9001 aaacagatac cctgttcatt tcctgcctgt gcctggaacg tcctttatct gtccagggat
     9061 gttacatact acattgtact tttctggatt atcgtgggca agccatctta ttcagtggtc
     9121 ctagcggcat tggcaaatcg acgcatgcca acctgtggtg ccggcatatt cccggcaccc
     9181 aggtactcaa tggcgaccgt gccctgctct gtccacttcc aaacggcgac tacgagataa
     9241 cgggatggcc tgtatgcggt tccagcggta tctgtcacaa tgaacgccgc ccgttggagg
     9301 ccattgtatt catcgaacag gcatctgata acaccatccg tccccagaca gccatgaagc
     9361 atttcaaagc tctctgctcg caggttacaa tcaactggtg gaatccaaag ctcaccggca
     9421 aagcactcga cgatctgcag gttttgacca gacagacaag catcagcacc tatgcgtgca
     9481 acatgaatcc ggaagcagcc ttcaccctgc acaggtatct gaccaaactg gaaattatcc
     9541 gataatgtga aatacgcccc attatgaaga ctgtcgatac gaaagaatac atatccatgc
     9601 tgcgtaccct cattgaggaa ggaaagcagg tgagcatgat catctcgggc agcagcatgg
     9661 ctccattcct gatccacgca agagaccaca tctgcctgaa aagcccctcc ggtgaacttc
     9721 ggaaaggaga tatggtgttc tatcagcgaa gcaacggtga atatgtcatg caccgtattt
     9781 ataatgttaa aaatgaagaa tattatctta tcggtgacgc ccagactgtc atcgaaggtc
     9841 caattcaaag agaacagatt ttcgccatca ttatcaaggt gaagcgaaaa gggaaatgga
     9901 tagttccaga agatttccag tggaaattct tcgcccacat atggccgaac ataattcctt
     9961 tacgcaggac catcattaaa acatatcgtt ttttcaaaag atgaaaagaa ccaaagaatt
    10021 tatcaaacga aacatagccg gagaaatcgt actggttcct tccggacaga ccgcccgaga
    10081 gttcaacgga atggtcaccc tgaccgaaac cggagaattt atctgggagc atatcgaaga
    10141 agcagaaagc ttcaaccatc tagtactgtt gattctggag gaatacgaag tggataaaga
    10201 caccgcatcg caagatgccg caggatttat catgcaactg ctgcaagccg gcatgatccg
    10261 tcccacaggt ataaactggt aaacagtaat ctgttcaatt cagatatgac aaacaataca
    10321 ataagaaatg ttagaagaga gattcgtttt cttcgcgaga agcgccggat ctgtaaaaaa
    10381 tgttagatca ggtaagttca agaccctatg ttatcagcgg ataatagaat gaacttacat
    10441 tttattcccc attacatctg cctgtgaagg tcgatgtaat tttaactata aataggataa
    10501 tgcaataata taaagacaat gagactcaat tctaatttaa ttcttcgcca agtaggtgga
    10561 gaatatatga ttgtcaatcc gttttctgaa accatggata tggcacaggt ctattccttg
    10621 aatgaaacag ccgcctggtt atggaaacaa ttggaaaaca aggaattcac ggtagatgaa
    10681 gccggagcac tgctgtgcaa tgaatatgaa gtaaataaag atacagcccg aaacgatgcc
    10741 aacgagctgt gccgacaatg gttagaaact gggttagcca tagaataaga caaaaagatg
    10801 atctcagccc cattacaaaa ggctttcatg cttttgctaa ggcaaggact gtgggaccgg
    10861 caggaagact gttccgccct ttttcctcta gatgaaaagg aatggaatga aattcacagc
    10921 atggcaagaa aacaaaccgt acaaggtatt atttacgatg gcatccgcct gttgccgact
    10981 gaagccgtac ctccccggaa ggtattgctt ggctggatgg tggaagttga caccttggaa
    11041 cgggtgaacc ggcaacaccg ggaaacgatt aaagccctcc aacagattta tgtacaatca
    11101 ccttctatcc ctttcctgct gctaaaaggg atagggacag ctgacttcta ccctcatccg
    11161 gaacatcgca tagccggaga catcgacctg tggttcggaa acaagacaca aaccgaacaa
    11221 gccaaccaac ggatggaaaa attaggatta ccggtaaaaa gaggaaccaa tggtgaggct
    11281 tcctgtctga taaacagagt tctgattgaa catcacagca ggctgataga gttgcacaac
    11341 cctttcctcc aaaaagaaat ccgccaatgg gaagcggggg tctttaccaa cagccaaggc
    11401 aaacttccga gcgaagcgaa tcatctatta ctttccaccc acatattgaa gcatcttatc
    11461 aatgaaggga tcggactacg acaattgtgt gatatagcca tggcttttaa cgcattacat
    11521 tctgttacaa acaaaaacga attagagtgt atctgtcgca aatggcacat tcaccggtgg
    11581 aaccggttac tttatgccct attgataaaa tatcttggcg tgccggccga ccttttacca
    11641 ttcagtacca gtctctgtcc ggacaagtta atgcaagaga tttgggaaag tggcaatttt
    11701 ggacatggag acgaacgtta cggtgaacgt cccaccggga aatgggcgaa caaacgatac
    11761 acgttgaagc ggatctttca caaaacgcac ttatcgttag gttatgcttt cgacgaaact
    11821 ttctggtggc tggccggatt agccctctta cgtttcaagg aaatgataaa aaagaaatga
    11881 aagaattgct gaaaaaattt ttgcagaagc tcacacggga gaatctgagc aatacatgtc
    11941 agttaggatg gaaagctttc aaatgggtta tgcaggtaac agaaggatac cattggctca
    12001 tcaccttctc tatcttttcg ggtattttcg gagtggtcat gtcattggtc aatgtggcca
    12061 tgtccaaatg gatcatcgat gtagctaccg gagcacagga agggaatatt tacctggtag
    12121 ccacaatagt agccttatcc ttcctgctgg gtatggggat aaaacttgta tctccctgga
    12181 tttttggcaa gatcaacatg cgcatcagta tccgcatgca aaattcgctg tccgacgccc
    12241 taatgatgtg ttcatggaaa ggagcaggga aatggcacac aggcgacctg ctgacccgta
    12301 tcagcagtga cgcttccgaa gtgttgggaa tgggaatggg cattctaccc aacctgctgg
    12361 ttaccggctt gcaattggca agctctttta tctacttgtg gattcttgac gcgcgtttag
    12421 cttggttcat actgggagtc acccctcttg ttttattgtc aaagatttat ttcagaaagg
    12481 tccgggaact gagctgtgcc caaaaaaaga tgaacagcga gatgggtacc gtcatgcaag
    12541 aaaatctgtc caaacggatt ctagtccgct cgctcggagc caccaactac cggaaacaga
    12601 aattacatga aacacaagag aagttgttca aattgggaat ggaacaaatc aaattttcca
    12661 cttttacgca aggggtcatg ggatttacat ttggaggagg gtacttatgt gcattccttt
    12721 ggggtatttt ccaactgcat aaccacgaga taacattcgg aacaatgaca gcctttcttc
    12781 aactggtcgg acaggtacag ggaccttttt tagggttaat atccatccct cccagtctga
    12841 tacggggatg gacctccgtg gaacggttaa tggccctctt tgaagatgta gaaccggacg
    12901 aacacccggt ctacatagac caaccactga cactgaactt tcggaaagtg tcttttggct
    12961 atgaagaggg acagccggta ctcgaccggt ttacagctgc ctttcatccg ggaagttcca
    13021 ccgccatagc cggacctacc ggaacaggaa aaacgaccat tatccggctg atactggctt
    13081 tggtttatcc ggaaaaggga cgcatcgatt tgacaactga tgacggacgg acactcagtg
    13141 tgacccccga tttacgcatc aacttcgtct atgtgcccca aggaaatacg ttgctgagcg
    13201 gtaccatccg ggagaattta tggctgggta gtccgggagc agacgaagag gctctgcata
    13261 aagtcatccg gctggcctgc gctgaatttg tgttcagtct gccggaagga ctagatacca
    13321 agatagggga acatggatat ggcttgtctg aaggacaagc ccaacggatt gcaatagccc
    13381 gcgcactgtt gcgtcccggg cggatctggc tgtttgatga agcatcatcg gcacttgaca
    13441 ccgagaccac cacacacctc atggacaatt tgttgcaatg gggaaagaat aacacattaa
    13501 tatttgtgac acacgattca cgactgatgg aacgatgtga ccaagtgatt catataaagg
    13561 aataaaaaac aattaattat aaaacaatgg ataaaacaat caaactggcc tgtctgttgg
    13621 caataatcat ttttagttcg tgcgcttcac gcaaagattt tgtctattta caagatatgg
    13681 atgaactaca ggaatatcct atggttcaaa aatatgaagc catcatccat agggatgaca
    13741 gattgagtat tattgtgaac agcaaaaacc cagaactgtc cctgcctttc aatatgtccg
    13801 gaagcagaag ctattctgta gaagcagacg gaagcatttc caacaatgaa gtgggggtat
    13861 taagtgatga aaaagaaaaa ggttatttag tggatatcaa cgggaatata gactttcctg
    13921 tgctgggaca actgcatgtg gaaggactga cccgccgaca attaaccgaa ctgataaaaa
    13981 aacgactgat caacgaagaa ttgctgaaag atcctatggt caccgtcaat ttcttgaact
    14041 tcaaattctc cgtgctagga gaagttggac atgtaggaac ctttgaagtg aaaggcgacc
    14101 gcatcactct tttagaggct cttgccatgg ctggagacct gaccccccga tcccgtctgg
    14161 accgtatcgc cgtcatccgc gaatatggga acaagcgacg aatcctgttc cacgacatcc
    14221 gcagcaaaga catcttcacg tcgccttact attacctgca acagaatgac attgtctacg
    14281 tagaacctac caacatgaag gccaccgaac aagcccagag aaaactgagc acatggagta
    14341 tgatcctgtc cttcatcacc acaatcacct cgctggtatt gctgactact aaataaaaaa
    14401 gaaacgacat gataagaatg agtgaacaaa aagatatgtc gggagataag accttaagcg
    14461 ggggaggatt caatatcaac cccgttgaca tcatcatgta cctgttgtcc aaatggtact
    14521 ggtttgtatt gtcggtcagt ctgttcggcg gatatgcatg gtatcaatat gccaaacttc
    14581 cctttatcta ttcacggtca gccaccgtca tgataaagga cgcctattca aacaacatcg
    14641 gtcgcgggct ggaccgtttt aacacctatt catataccaa tgtatccaat gagatcctgc
    14701 aattccagtc acacaaactc atgcgcgatg tggtgaaccg tcttcacgcc aatgtatgct
    14761 acctcatcat ggatgacttg cgtgaggagg aactttatac gcaagcccct gtcaaggttt
    14821 cattcccgga agaagaggat catcttgatt tcagcctgac agtcagaatc cagaacagga
    14881 agcaagtccg gttatccgat ttctcgacag acgccacaag tataacgcta acagccaatc
    14941 tgggtgacac catccaatcg cccataggaa aaatagtggt ctcacccacc ttatattata
    15001 ggtgagttct atcaattcaa tttatcctct tgtatcagac agcagaactc t
//
