Select genomic region:
Overview
9.1
11.1
21.1
49.1
50.1

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaLJOLFEFE_222 (original name was: gnl|Prokka|LJOLFEFE_222)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | T3PKS | 1,961 | 43,136 |

gnlProkkaLJOLFEFE_244 (original name was: gnl|Prokka|LJOLFEFE_244)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 11.1 | hglE-KS | 1 | 25,368 |

gnlProkkaLJOLFEFE_343 (original name was: gnl|Prokka|LJOLFEFE_343)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 21.1 | lassopeptide | 4,074 | 25,618 |

gnlProkkaLJOLFEFE_696 (original name was: gnl|Prokka|LJOLFEFE_696)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 49.1 | RiPP-like | 60,022 | 78,807 |

gnlProkkaLJOLFEFE_807 (original name was: gnl|Prokka|LJOLFEFE_807)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 50.1 | RiPP-like | 73,881 | 81,194 | quinolidomicin A | Polyketide | 3%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 9.1 | T3PKS | 1,961 | 43,136 |
Region 11.1 | hglE-KS | 1 | 25,368 |
Region 21.1 | lassopeptide | 4,074 | 25,618 |
Region 49.1 | RiPP-like | 60,022 | 78,807 |
Region 50.1 | RiPP-like | 73,881 | 81,194 | quinolidomicin A | Polyketide | 3%

No secondary metabolite regions were found in these records:
  gnlProkkaLJOLFEFE_1 (original name was: gnl|Prokka|LJOLFEFE_1)
  gnlProkkaLJOLFEFE_2 (original name was: gnl|Prokka|LJOLFEFE_2)
  gnlProkkaLJOLFEFE_113 (original name was: gnl|Prokka|LJOLFEFE_113)
  gnlProkkaLJOLFEFE_167 (original name was: gnl|Prokka|LJOLFEFE_167)
  gnlProkkaLJOLFEFE_178 (original name was: gnl|Prokka|LJOLFEFE_178)
  gnlProkkaLJOLFEFE_189 (original name was: gnl|Prokka|LJOLFEFE_189)
  gnlProkkaLJOLFEFE_200 (original name was: gnl|Prokka|LJOLFEFE_200)
  gnlProkkaLJOLFEFE_211 (original name was: gnl|Prokka|LJOLFEFE_211)
  gnlProkkaLJOLFEFE_233 (original name was: gnl|Prokka|LJOLFEFE_233)
  gnlProkkaLJOLFEFE_255 (original name was: gnl|Prokka|LJOLFEFE_255)
  gnlProkkaLJOLFEFE_256 (original name was: gnl|Prokka|LJOLFEFE_256)
  gnlProkkaLJOLFEFE_267 (original name was: gnl|Prokka|LJOLFEFE_267)
  gnlProkkaLJOLFEFE_278 (original name was: gnl|Prokka|LJOLFEFE_278)
  gnlProkkaLJOLFEFE_289 (original name was: gnl|Prokka|LJOLFEFE_289)
  gnlProkkaLJOLFEFE_300 (original name was: gnl|Prokka|LJOLFEFE_300)
  gnlProkkaLJOLFEFE_311 (original name was: gnl|Prokka|LJOLFEFE_311)
  gnlProkkaLJOLFEFE_322 (original name was: gnl|Prokka|LJOLFEFE_322)
  gnlProkkaLJOLFEFE_332 (original name was: gnl|Prokka|LJOLFEFE_332)
  gnlProkkaLJOLFEFE_354 (original name was: gnl|Prokka|LJOLFEFE_354)
  gnlProkkaLJOLFEFE_365 (original name was: gnl|Prokka|LJOLFEFE_365)
  gnlProkkaLJOLFEFE_366 (original name was: gnl|Prokka|LJOLFEFE_366)
  gnlProkkaLJOLFEFE_377 (original name was: gnl|Prokka|LJOLFEFE_377)
  gnlProkkaLJOLFEFE_388 (original name was: gnl|Prokka|LJOLFEFE_388)
  gnlProkkaLJOLFEFE_399 (original name was: gnl|Prokka|LJOLFEFE_399)
  gnlProkkaLJOLFEFE_410 (original name was: gnl|Prokka|LJOLFEFE_410)
  gnlProkkaLJOLFEFE_421 (original name was: gnl|Prokka|LJOLFEFE_421)
  gnlProkkaLJOLFEFE_432 (original name was: gnl|Prokka|LJOLFEFE_432)
  gnlProkkaLJOLFEFE_443 (original name was: gnl|Prokka|LJOLFEFE_443)
  gnlProkkaLJOLFEFE_454 (original name was: gnl|Prokka|LJOLFEFE_454)
  gnlProkkaLJOLFEFE_465 (original name was: gnl|Prokka|LJOLFEFE_465)
  gnlProkkaLJOLFEFE_476 (original name was: gnl|Prokka|LJOLFEFE_476)
  gnlProkkaLJOLFEFE_477 (original name was: gnl|Prokka|LJOLFEFE_477)
  gnlProkkaLJOLFEFE_488 (original name was: gnl|Prokka|LJOLFEFE_488)
  gnlProkkaLJOLFEFE_499 (original name was: gnl|Prokka|LJOLFEFE_499)
  gnlProkkaLJOLFEFE_510 (original name was: gnl|Prokka|LJOLFEFE_510)
  gnlProkkaLJOLFEFE_520 (original name was: gnl|Prokka|LJOLFEFE_520)
  gnlProkkaLJOLFEFE_531 (original name was: gnl|Prokka|LJOLFEFE_531)
  gnlProkkaLJOLFEFE_542 (original name was: gnl|Prokka|LJOLFEFE_542)
  gnlProkkaLJOLFEFE_553 (original name was: gnl|Prokka|LJOLFEFE_553)
  gnlProkkaLJOLFEFE_564 (original name was: gnl|Prokka|LJOLFEFE_564)
  gnlProkkaLJOLFEFE_575 (original name was: gnl|Prokka|LJOLFEFE_575)
  gnlProkkaLJOLFEFE_586 (original name was: gnl|Prokka|LJOLFEFE_586)
  gnlProkkaLJOLFEFE_587 (original name was: gnl|Prokka|LJOLFEFE_587)
  gnlProkkaLJOLFEFE_598 (original name was: gnl|Prokka|LJOLFEFE_598)
  gnlProkkaLJOLFEFE_609 (original name was: gnl|Prokka|LJOLFEFE_609)
  gnlProkkaLJOLFEFE_916 (original name was: gnl|Prokka|LJOLFEFE_916)
  gnlProkkaLJOLFEFE_1027 (original name was: gnl|Prokka|LJOLFEFE_1027)

Compact view
gnlProkkaLJOLFEFE_222 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,961 - 43,136 nt. (total: 41,176 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaLJOLFEFE_244 - Region 1 - hglE-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 25,368 nt. (total: 25,368 nt) Show pHMM detection rules used
Region on contig edge.
hglE-KS: (hglE or hglD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
NRPS/PKS modules
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 25368:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mxmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg11_1: mxmal
  PKS_AT (30..322): mxmal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Methoxymalonyl-CoA
  Prediction, score:
    Methoxymalonyl-CoA: 21.7
    Methylmalonyl-CoA: 17.9
    Malonyl-CoA: 10.8
    Propionyl-CoA: 10.6
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0

gnlProkkaLJOLFEFE_343 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,074 - 25,618 nt. (total: 21,545 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lasso peptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for allorf_16589_16747

allorf_16589_16747
Leader:
MLWKNRKETVMYQKPTITKIGNYRTLTN
Full core:
GAGKARERDLLGFSALIVIHWPWG
Putative macrolactam:
GAGKARERD

#### antiSMASH-DB 4.0 matches for allorf_16589_16747

87.5% NZ_NCVC01000017.1: Lassopeptides: B7703_RS09865_lassopeptide
1
GAGKARERDLLGFSALIVIHWPW
23
GAG ARERDLLGF ALIVIHWPW
1
GAGTARERDLLGFRALIVIHWPW
23
66.7% NZ_FNCN01000047.1: Lassopeptides: BLQ73_RS31810_lassopeptide
3
GKARERDLLGFSALIVIHWP
22
G ARERD+LGF ALIVIH P
3
GSARERDILGFRALIVIHPP
22
50.0% NZ_CP118615.1: Lassopeptides: PVK37_RS09555_lassopeptide
3
GKARERDLLGFSALIVIH
20
G A ERD+ G+ ALIVIH
3
GSADERDIFGYRALIVIH
20
with 2 more sequence matches
29.2% NZ_CP113264.1: Lassopeptides: OUQ99_RS00955_lassopeptide
3
GKARERDLLGFSAL
16
G+ D+LGF AL
3
GRLSCNDILGFRAL
16
20.8% NZ_CP030117.1 and 1 other:
NZ_CP042161.1 Lanthipeptides: allorf_1767960_1768070_lanthipeptide
Lanthipeptides: allorf_3078198_3078308_lanthipeptide
18
VIHWPWG
24
+ HWPWG
7
ICHWPWG
13

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lasso peptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_16589_16747 - Class II
  Cleavage pHMM score: 0.10
  RODEO score: 21
  Monoisotopic mass: 2630.4 Da
  Molecular weight: 2632.0 Da
  Number of bridges: 0

gnlProkkaLJOLFEFE_696 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 60,022 - 78,807 nt. (total: 18,786 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaLJOLFEFE_807 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 73,881 - 81,194 nt. (total: 7,314 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.