LOCUS       c00114_gnlPro..        16528 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LNEPBKDE_221.
ACCESSION   c00114_gnlPro..
VERSION     c00114_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 06:33:16
            Original ID  :: gnl|Prokka|LNEPBKDE_221
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16528
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16528
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3110:6668](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3111..6668
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16528
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16528
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(538..1692)
                     /locus_tag="ctg114_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDWKFSPWGWDPALRKRLMTLGAGQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGVFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1872..3077
                     /locus_tag="ctg114_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3111..6668
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg114_3"
                     /sec_met_domain="PFOR_II (E-value: 5e-19, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.1e-83, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.8e-32, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.5e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 4.6e-08, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6793..6981
                     /locus_tag="ctg114_4"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6992..7852)
                     /locus_tag="ctg114_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVIPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(7880..8710)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg114_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8707..9933)
                     /locus_tag="ctg114_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10406..11692
                     /locus_tag="ctg114_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RNFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPIPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11655..11987)
                     /locus_tag="ctg114_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(12015..14768)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.3; E-value: 4.2e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg114_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 7.4e-21, bitscore:
                     64.3, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTMRYLKWMLVLFGLIGMTACRQDTPRFRIGVAQCSDDSWRHKM
                     NDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISANEAAPMTPIVEE
                     AYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKGNIVELTGLSGST
                     PAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPKIDAVYAHNDRIA
                     PGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPTNGDKVLQLAMDI
                     LEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIGGYLSQVATQQVV
                     LYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLEEQRDQLIQLSHQ
                     LEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQHRMLMLIQRNVNILLR
                     LVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHFSFDSMPDTDYHT
                     LADMEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTVANTGSMISAEHI
                     RNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVFTVELPVQSCEAV
                     AAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIRSYVHTLLHTDYT
                     VIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTCHIPVILLTACSL
                     DEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDK
                     DFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKA
                     ASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(15101..16327)
                     /locus_tag="ctg114_11"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGHRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 aactaattca gttataacaa acgaagttgt caactaaaac cagtacacat cattccattg
       61 cttgaaacca gagtttcatc ggtgtgaaac tgtagtttca tcggtgagaa actagagttt
      121 catacgcttg aaactttagt tccaaacgct cgaaactatc tgaaactact gttgatttga
      181 ttgacttaac cgcatgttcc aatcacattg aacgcatcag ctacttcaat agtactgctc
      241 tctctgaaaa cattaaatca tatatcagtc aataatacat aaattatcag tccttaatac
      301 ttgatttctc aattattaat atctgagaaa tcaaacgtta acagttgaga tatcagatat
      361 taacatcctg taaatcaaag aataacacag taaaaacagt atttatcagg acgatgcaga
      421 gtgagagcaa gtccttgctc tcactctgct accactggat ctctaacagc taaaacatcg
      481 atgaataaag ggatacagac gaactgttag agcatgagag caaaagcact atctttttca
      541 ctgggggaga gtaagcaaaa gaaacgcacg ataccggctt tgaggcgtca ccggtactaa
      601 cggcaaatat ccggcacaca cccgattatt ctctacggac aaagggaacg aagccgacat
      661 ctgccgatgt tcctccaaag cctgaccggc taaaggataa taatcaatcc gaaaaactcc
      721 ttccgcatcc gcagccaaat aacgatccgt caagagccat gccaccaccc ccatattcat
      781 tcgcagatta atttcgacac aaggatgaat ccggtaaaca ggcgcttcat ccggaaaatg
      841 acaaatcatc atatccactc ccaagtatcc atgataaaag ccaccgaaca aagctgacaa
      901 ttcttcttcc aaacgagtcc gcagcctgat aaattcttct tgtggcacat aagccgatag
      961 tttctgcaga atcttctcgt cagacagcaa gtcattccct gcatacatcc cactcccacc
     1021 cgtgtggaag accgaatatc cggcaaaaac aacccttcct ctcccgtcag cataaaactc
     1081 catagcgaaa tcttccacct tattatatat aggttcgcct accaccccac cctgagaagc
     1141 agcgacacgg gcacaccaac cggaaataaa agtagtaaat atgcctttac accaattcaa
     1201 tcctttcccg cttccggaaa gcggagcttt taacaagcac gcttcccgcc cttcgacgaa
     1261 cgcactgcac tccgccaaag tactcaaata aaaagattct ccacagaagt attcattcaa
     1321 ccgcaaccca ggcaacaact ttaccgcctg cagacgatgc gaatgctctc tcagaatatt
     1381 catataatcc gcagaaggca gctccgtctg acctgccccc aatgtcatca aacgcttccg
     1441 caaagcaggg tcccaacccc acggagagaa cttccagtct ttaccgtcag ccacttccgg
     1501 ttccgtcaac aaggccacat ccatgcccaa aagttcactc tttgttttca ggaagtccgc
     1561 attataagca gacggtgcaa gcaccgcact tcccgcttcg gcataccaca taggaagcaa
     1621 cgccaggtca ctcgccatct gtcgggcgga agccggcgcc atatagttcg tctcaccgct
     1681 tgccaacgcc atatcatgct ccggattgaa tatataaaca ggtcttttcg tcatgtcaaa
     1741 gatggattca acacattatt ctgcaaatat atacaggaaa taatcaggaa cttacacaat
     1801 aaagagaaac ttataaatta aagcacattt ttgctatctc tactttgcaa atcctaaaaa
     1861 aagcactata tttgccagcc gaaaaacaaa gaaacgaaat ggaatcattc tatcgcacac
     1921 acgcctacct cgttgagcac accaatgccc ccgttcgccg cgatcttatg gacgagatcg
     1981 actggagtga ccgtctgatt ggtatcaaag ggacacgtgg cgtaggaaaa accactttcc
     2041 tcctgcagta cgccaaagag aaattcggca ccgaccgttc ctgtctgttc atcaatatga
     2101 acaactttta tttctccggt cacagccttg ttgacttcgc caacgagttt cagaaacgtg
     2161 gcggaaaagt actgctgatc gaccaggtgt tcaaacatcc cgaatggagc aaagagctac
     2221 gaatgtgcta tgaccgtttc cccagcctga agattgtctt caccggttct tccgtcatgc
     2281 gactcaaaga ggaaaacctc gaattgcgtg acattgcgaa aagttataac ctgcgcggat
     2341 tctctttccg tgaatttctg aacctgcaga caggaatgaa attccgggca tacagcctcg
     2401 aagaaatcct cagtacacat gaacagatag ccaaaggagt actttccaaa gtacgaccgc
     2461 tggattattt tcaggattac ctgcatcatg gtttctaccc tttcttcctt gaaaaacgta
     2521 atttctcgga gaatctgctg aaaacaatga acatgatggt agaagtggat atcttgctga
     2581 tcaaacaaat tgagctgaaa tatctttcaa agataaaaaa attactatat ttgttggctg
     2641 tggacggacc gaaagctccg aacgtgagcc aactggcaag tgacgtacag acatcccgcg
     2701 ctacggtaat gaactatatc aagtatctgg cagacgcgcg tctgattaat ctggtttacc
     2761 cgaaaggaga agaattccca aagaaaccgt caaagattat gatgcacaac tctaacctga
     2821 tgtactccat ttatccggtg aaagtggaag aacaggatgt actcgacacg ttcttcgtta
     2881 acactttatg gaaagaccat aaggtacata aaggagataa aaacgtctct ttcatggtag
     2941 acgaagtgat gccgttcaaa atttgtgcgg aaggtacaaa aataaagaat aacccggacg
     3001 tgacgtatgc gttgcaaaag gccgagatag gccgcggcaa ccaaatacct ctttggatgt
     3061 tcggattctt atactaaaaa gatttattta cttaaatatt taatttagtt atgactaaac
     3121 agaagaaatt catcacatgt gatggtaacc aagctgcagc acatatctcg tatatgttct
     3181 ctgaagtagc agctatctac cccatcactc cttcttcgac tatggctgag tacgtagacg
     3241 aatgggctgc cgcaggacgt aagaacatct tcggcgaaac agtattggta caggaaatgc
     3301 aatctgaagg tggtgctgcc ggtgcagttc acggttctct tcaggctggt gcattgacta
     3361 ctacttacac tgcttctcag ggtcttcttt tgatgatccc taacatgtac aagattgccg
     3421 gtgaattctt gccttgtgta ttccacgttt ctgctcgtac actggcttct cacgcattgt
     3481 gtatcttcgg tgaccatcag gacgtaatgt cagctcgtca aaccggcttc gctatgttgg
     3541 cagaaggttc tgtacaggaa gttatggatt tggcaggtgt tgctcatctg gctactatca
     3601 aatcacgcgt tccgttcatg aacttcttcg atggtttccg tacttctcac gaaatccaga
     3661 agatcgaaat gttggaaaac gacgacctcg ctccgctgat cgaccaggaa gctttggctg
     3721 aattccgtgc ccgtgcactg aatccgatga agccggttgc ccgtggtatg gctgaaaacc
     3781 ccgaccactt cttccaacat cgtgaatcat gcaataacta ctatgaagca gttcctgcta
     3841 tcgtagaaga atacatgaac gaaatttcca agatcacagg ccgcaaatac ggtttgttcg
     3901 attactacgg tgcagaagat gcagaacgcg taattatcgc aatgggttct gtaactgaag
     3961 ctgcccgcga agctatcgac cacttggtag caaacggcga aaaagtaggt atggttgccg
     4021 tacacttgta tcgtccgttc tctgctaaac acttcctggc tgctgtaccc aagactgcaa
     4081 agagcatcgc agtgcttgac cgtacaaaag aaccgggtgc taacggcgaa cctctttacc
     4141 ttgacgttaa agactgcttc tatggcgcag aaaatgctcc tgttatcgtt ggcggtcgct
     4201 acggtctggg ttcaaaagat accactccgg cacagatcat ctctgtattc gaaaacttgg
     4261 ctatgccaat gccgaagaac cacttcacta tcggtatcgt agacgacgtt acgttcactt
     4321 ctcttcctca gaaagaagaa atcgctctgg gcggtgaagg tatgttcgaa gctaaattct
     4381 acggtctggg tgctgacggc acagtaggtg ccaacaagaa ctctgttaag attatcggtg
     4441 acaacaccga caaacactgt caggcttact tctcttacga ctccaagaag tcgggtggtt
     4501 tcacttgttc tcacttgcgt ttcggtgata ctccgatccg ttctacttac ttggtaaata
     4561 ctccgaactt cgttgcttgt cacgttcagg cttacctgca catgtacgac gtaacacgtg
     4621 gtttgcgtaa gaacggttct ttcttgctga ataccatctg ggaaggcgaa gaactggcta
     4681 agaacctgcc taacaaggtg aagaaatact ttgcacagaa caacatctct gtatactata
     4741 tcaacgcaac tcagattgca atggaaattg gtttgggcaa ccgtaccaat acaatccttc
     4801 agtctgcatt cttccgtatc acaggcgtaa tccctgtaga tcaagctgtt gaacagatga
     4861 agaaattcat cgttaagtct tacggcaaga agggtgaaga cgttgttaac aagaactacg
     4921 ctgctgtaga ccgcggtggt gaatacaaga ctctgactgt cgatcctgct tgggctaacc
     4981 tgccggatga tgcaaaagca gaaaacaatg atcctgcttt catcaacgaa gtagttcgtc
     5041 cgatcaatgc acaggacggt gacttgctgc cggtatctgc attcaagggt atcgaagacg
     5101 gtacttggta tcaaggtact tccaaatacg aaaaacgtgg tgtagctgca ttcgttcccg
     5161 aatggaatgc tgaaaactgt attcagtgta acaagtgtgc ttacgtttgt cctcacgctt
     5221 ctatccgtcc gttcgtactc gatgctgaag agcagaaggg tgctaagttc gagcaactga
     5281 aagctgtagg taaagcattc gatggtatga cattccgtat tcaggtagac gttctcgact
     5341 gtctgggttg cggtaactgt gccgacatct gtccgggtaa tccgaagaag ggtggcaagg
     5401 cattgaccat gaaacacctt gaaagccagt tggccgaagc tgataactgg acttactgcg
     5461 ctgaaaacgt gaagagcaaa caacacctgg tagacatcaa ggctaacgtg aagaactctc
     5521 agttcgcaac tccgttgttt gagttctcag gcgcttgctc cggttgtggt gaaactccgt
     5581 acgtgaaact gatttctcag ttgttcggtg accgtgaaat ggttgctaac gctacaggat
     5641 gttcttctat ctactccggt tcagttcctt ctactccgta cactatgaac gaaaagggtc
     5701 acggtcctgc atgggctaac tccttgttcg aagacttctg tgaatttggt ctgggtatgg
     5761 aactggctaa cgaaaagatg cgtgcccgtc tggtgaaagt aatgaacgaa gctatcgctt
     5821 ctgattgctg cccggctgaa tacaaagaag tatttgctga atggatcaac aatatgctgg
     5881 atgcagaaaa gactaaggaa ctggccgaaa agatcattcc gatggtagaa gctgctaaag
     5941 ataaatgcaa ccactgcaag caaatcgctg atctgcaaca atatcttgtt aaacgcagcc
     6001 aatggatcat cggtggtgac ggtgcttctt atgatatcgg ttacggtggt cttgaccatg
     6061 taatcgcttc cggtaaggac gttaacatcc ttgtattgga tactgaggtt tactctaaca
     6121 caggtggtca gtcttctaaa gctactccgg taggcgctat cgctaagttt gctgctgcag
     6181 gtaagcgtgt acgtaagaaa gacctcggtc tgatggctac tacttacggt tatgtatatg
     6241 ttgctcagat tgctatgggt gctgaccagg ctcagactct gaaagctatc cgtgaagctg
     6301 aagcatatcc gggaccatca ctgatcatcg cttacgctcc atgtatcaac cacggtctga
     6361 aagccggtat gggtaagagc caggaagaag aagaaaaggc tgttaagtgc ggttactggc
     6421 acttgtggcg ttacaaccct gctttggaag aagaaggcaa gaatccgttc caactggata
     6481 gcaaagaacc taactgggaa gacttccaag gtttcttgaa gggtgaagtt cgttacgctt
     6541 ctgtaatgaa acaatatcct gctgaagctg aagaactgtt taaagctgct gaagaaaacg
     6601 ctaaatggcg ttacaacagc tacaaacgtc ttgccagaga aaactgggga gctgatacag
     6661 ctgaataata agtagaaata ctttatacat aataaaaggc aggaatcctg gaaacagatt
     6721 cctgcctttt ttgtttatat cttagaagta acgattactt ctcacgaaga tattcattaa
     6781 aactctaaag atatgatcgg atttgttatt tggattatcg gtttgatact gactttcaga
     6841 gctgccatag agatttggaa tataaatgcg gctgtagaga aaagacttat agcgattgta
     6901 ttaatcgttc ttaccagctg gctgggacta cttttctact acttctatgg taaagaaaga
     6961 atggcaggat ggttgaagta gtgtttgcat atcaatcttt ctcaggaatc caactgttta
     7021 ccagttcctg atgttcttcc atccattgac gggcagcctg tctttccgtt gtctgcgcct
     7081 cttccagagc agtcattaaa gagctgattt ccgcatctgt cagacgaatg ttgcccaaaa
     7141 gttcggcagc aaaagggtct ttctcgctaa aacctttcca tgctatggta tgaatggatt
     7201 ccgtatttcc atatatcagc ttcgggtcct gaagaacttt cagcttgaaa cggtcgaaca
     7261 tccagtgagg cgtccatccc gtcacgacaa tccagtcttt cttatcaatc gctttcttta
     7321 gggaagcagt catggcaggt ccgctcgaag tcatcagttt ataatccaat ccatagtctt
     7381 tgatggcctg atcggtagct ttcataatac cggctccggc atcaataccg acaatctgac
     7441 cggagaaacg ttccttttcc gcgttcagtt cttcgattga gttgatcgta acgtaatccg
     7501 gaatcaccag cccgatacgg gcaccatcat aaatatcccc gataacttcg agtttatccc
     7561 cgtattgttt catataatct tccatagtga caggcatcca gacatccata aatacgtctg
     7621 ctttcttacg ggagatagag gtaaatatag gtgcaaggtc ggcattcagc aactttacat
     7681 cgtacccctg atcttcaaaa atcgctttgg caaggtttgt cattgcaata ccttccgacc
     7741 agttggcata agcgatactt atcttcttac tctttccgtt gtctccgcag gaaacgaagg
     7801 ttaagagtat gccggcaata aacattgccg caatcatttt tatcttattc attgattatt
     7861 cctttctttg gtgtgattct tatttctttt tactttttct gttatctgcc ataccctgag
     7921 tgatgcggtc cagcacgatc gccaatatca cgactgcgat accgccttca aatccgagtc
     7981 cgattttcat ttgggtgata cctttcagca cgatttctcc caaccctccc gcagaaatca
     8041 tggcggcaat cactaccatc gaaagtgaca tcatgatcgt ctgattgatt cccgtcagaa
     8101 tagtaggcaa tgccaaaggc aattgcacct tataaagaag ctgccaggga gtagctccaa
     8161 aagaacggga ggcttctact acatttttag gaacctgacg aatgcccaga ccagtcagac
     8221 gaaccacagg aggcattgca aagatgatgg tggcaaaagc tcccggcaca gttcccaatc
     8281 cgaagaatag aacggcagga atcagataga caaaggcagg cattgtctgc ataaagtcga
     8341 ggacagggcg cattatcttg ttacaacgat cactgttggc agtccagatt cccaacggaa
     8401 cgcctaaaag caatgccaga caagtggaag aaagtaccaa tgccaatgtc tgcatcgttt
     8461 cttcccaaaa gcccatgccg taaataagca ataaacccaa gagggtaaat acggctgtcc
     8521 ccttacccga cttaaaccag gcgagcgcag ccagcactgc aattgtgata taaaaaggta
     8581 ttccaaacag tacgtgctga aaaccgtcta tgaatcctcc gatccccatg ctgagagcat
     8641 caaaaaagga agcaaaatgt tctgtgagcc aattaatggc agtctctata tattgtccga
     8701 tatttatcat aattctattg cgttttgaat gatttcatta atttcttctt tatcttttcc
     8761 cgttacttcg atgatcaatg aggaaagtgg cactacgcct tcaaactccc gattctcatt
     8821 tacgacccag attggcgagt tcgtttttgt catcaacgga agaatatctt ccagcaccgt
     8881 atcacccagc actgaatgaa cttcatgcct tactacggac tcgatggagc ggatttgctc
     8941 ttttcgtagt ttcagcaagt cattcaaccg cacctctcct actaacagat tattggaatc
     9001 gactaccgga agaacggtca gattccgttc gcgcatctta cggatcagca cctccgggcc
     9061 ttctttcttc aaacgtgcca ctatgggttt atctaccata acagaggaag ctgttataat
     9121 cttgcttcga tctacattct ccacaaatcg ttctacataa gcgttggcag gttcggtcag
     9181 gatttcttcc gatgtaccga tttgtacaat ttctccatcc ttcatgatag caatccggtc
     9241 acccaattta atcgcttcac tcaggtcgtg agtaataaag acaatcgttt ttttcatctt
     9301 cgactgcaaa gtcagcagtt catcctgcat ctgcacacgg atcaaaggat cgagtgccga
     9361 gaaggcctca tccatcaaca ggacttcggg attattggcc aaagcccgcg ccagcccgac
     9421 acgctgctgc atcccacccg acagttcact taccatctga ttctcgtagc ctttcagccc
     9481 caccagttgc atactttcca tcgctttctg ctcccgttct ccctttttta ctccctgtag
     9541 ttcgagcccg aaagctatat tatgcaagac agaacggtga ggaagcagac cgaagttctg
     9601 aaagaccata gccagttctt tccggcgaat ctgcaacagt tccttatccg acactttggc
     9661 tatgtctgtt ccattgataa tcacttctcc ggaagtaggg cgtatcaaac ggttgatgca
     9721 gcggagtaaa gtggactttc cactaccgga cagccccata atgacgaata tttcgccttc
     9781 attaatggaa agattcgcat ctttcaccgc aactgtacat ccggtcgctt tcaatatttc
     9841 actttttgtt ttaccttctt tcaacatctt caaagccttc tgcttctcat tgccaaaaac
     9901 cagatagaga tctttaattt ctattttact catacaataa aatggtttag gttattaaaa
     9961 taatatacac agcaagacaa gaacaaacga taacaggaat ctttctttat atcgtataaa
    10021 gttctgattt aaataaggga caaataacaa tgaatcccga aataattaat aaaatgatta
    10081 ttgacagact gagtaattaa aaaaggaata gaatttgata agataatcct ttcaacgaat
    10141 agcaaaaaat agcattttta tgtataaaaa cagcctgttc cagtatcttg ctggcacaaa
    10201 gatacaaaaa acggattaaa catacaaatt atattcaaaa tccggggcat acagagggct
    10261 ttatttgtaa tgatatggaa agtttccggg taatattccc ctatcactca gcaaaataga
    10321 acaaaccggc agataaatat aaaataagtt tgaatatttc acttaaacac cgtatatttg
    10381 gcgtcaataa ctaaactaga tttatatgtt caacagggct attacaattt tcctggggaa
    10441 ggataattgt cattacacaa caaaagaaaa acaaacaggt actgccacac tagacgacaa
    10501 aagccaagta cagttcctta gtaaaaagaa ccccaaaatg ccgtttttct atagccggcg
    10561 gaatctctac atgataggtt tcctgctcgc ttttatagtg actctgctcg aatttatacg
    10621 aggacggcat caaaacttta tggtcttctc ggacgctact caattcttct ggcaaggcat
    10681 cagcccatac acaactgaat ttgtagaagc tcacggacgc aacttccttt attctccagt
    10741 tttcacggta ttgttcgctc cgtttgcgta tctgcctgca tggctgggac ctttcgcgtg
    10801 gaatctattc aattattcgc tgttctttat ggcgatcttc acgctgcccc aacaattcac
    10861 ccagcagcag aaatgccgta tgttcctttt tctgttactg attttaggac aaagtttact
    10921 ttcatttcag tataacataa cggtagccta tttattctta ttcgcctata cgttattgga
    10981 aaaagaccgt ggatttctgg ctgttctgtt aatcatgatt tcgggatgta ccaaagtata
    11041 tggaattttc gaactggcat tgttgctgtg ctatcctcac gtatggcgta actttggcta
    11101 tgccgttaca atgggcattg tattgcttgc attaccgtta atcaaaatag ctcctgcaga
    11161 tttgctcccc tattatgaag aatggtgcca tagtcttgct gttcatcagt ccgccggagc
    11221 ttatgattca tttttctatg cccgccccat tgcagcatgg acattgccac acttccgtgc
    11281 acttcagata ggaatgctcg gcttgctgac tctgctcttt ttggggaatt tccgcaaatg
    11341 gtcgtctttt gccttccgtg cccaggcttt gggcattctc atgggctggg tagtattact
    11401 gagtgactcc gccgagaagc atacctatat tatcgcattg gcaggtttca tgctctggta
    11461 ttggagcaga ccaacacgta ccgcaacaga caagattcta ttttggtgct gttttgtgct
    11521 gttatgtatc gttcctatcg acatattcgt ccctataccc atcagagatt tcattaccag
    11581 gaccttatgg cttcatgtat gggttttctt tattgtatgg atacggatga tatggcttac
    11641 cttccttgca tccttcattc atccacgtgc cacaaatgtt ctttcagatt aacgcatccg
    11701 ttagctttga aagaaacttc ttctgccagc aagagttgtt tttgttccac ccaaccgggc
    11761 accagccttc cggtggaatt tacaactcta tggcagggaa tggataattc atccggcact
    11821 tctttcaatg cacgtcccac catccgcgag cattggggtg cccccaacag caaagcaata
    11881 cctccataag tagatacttt tcccacaggt atctgggata cgacttcgta cacttccttc
    11941 cgaaaggatt cggaaaagct ctctttatct actttataat ctttcatata tccctcttta
    12001 cgatatcaat gaaatcatcc tttccttttc aggaaatctg tcgggctctc tccaaactgc
    12061 tctttatagc acttggcgaa ataagaaggt gaactgaaac cgacttcata accaatctcc
    12121 gctacggtca tgtccgaaga agcaagcaaa gaagctgcct tcttcaaacg ggcgatacgg
    12181 agcaattcat tcggagagta gttagtcaat gatttaatct tgcgataaag ctgcacacgg
    12241 cttagtccca tgtctttgcc caagtcctcc acattcaaac cggagtctcc cattttctct
    12301 tcaatcaatg acttgaatct ttctacaaaa tccttgtcca tatcgcagac atcttctttt
    12361 gccaatgtct gcccgtcacc aaagaactgt ttcagacgac ggtgagaatc gatcagattg
    12421 cggacacgtg ccagcaacag ctgtgaactg aacggctttg aaatataaga atccgcacca
    12481 ccgtcatatc cctgaatacg ctgttcgtcc agtgaacacg ctgtcagcag aataaccgga
    12541 atatgacagg tctgtaactc acttttcagc cggcggcaac attcaatgcc atcaatgccc
    12601 ggcatcatca catcagaaat gatcaggtcc ggaacatact tcatagcctt acggattcct
    12661 tcggagccgt ctgccgcttc aatcaccgta tagtctgtat gcaacaacgt atggacatac
    12721 gaacggatat cctcattatc atcaataatc agtacggacg gtttggaaga gtcatatcct
    12781 ttttccagtt cttcctcttc cgccaataga acatctgttg tacgggaatc cgcagaaaca
    12841 agggtggtat ccggttcggc agcaacagcc tcacaagact gtacaggcag ttcaacggta
    12901 aagaccgtgc cctgtttctc atcgctctct acggagatca taccaccgtg catttctacg
    12961 aaggctttta ccaatgccag tccgattccc gaaccggtat ggtgcatatc gatcttatag
    13021 aaacggtcga atacattgcg aatatgttcg gcagaaatca tagaaccggt atttgccacc
    13081 gtgaaacgta tccatcgctt gtcctcttta ctaagggaag acagacggac ggctattttc
    13141 ccgttttccg gtgtaaactt aaaggcattg gacagaagat tgaaataaat acgttccagc
    13201 ttctccatgt ctgccagtgt atgataatcc gtatccggca tactatcaaa agaaaaatgg
    13261 atatgcttct tacgggctgc cgcctgaaaa gactcattcc atccttcgaa agaagaaagg
    13321 acatccaccg taaccggagt atattccatc ttgccgtttt catatttacg gaaatccaga
    13381 atctgattga ccagacgcag aagaatgttc acattccgct gaatcagcat gagcatccgg
    13441 tgctgatctc cgctcagtgt cttgtccgcc aacaaatgtt ctaccgggtc ggcaaccaat
    13501 gtcaacggag tacggaagtc gtgagaaata ttggtgaaaa agaccagctt ggcatgggta
    13561 gcttcttcca gttgatgaga gagctgtatc aattggtcac gctgttcttc cagtttgtca
    13621 cgctgctctt ccaattgctg cttctgctta aaaagctctt tattcaagcg attcttagag
    13681 cggagtgatt tataaacgac caataataag ccggctacca ataaaaggat aatcagactg
    13741 ccgtataaaa cgacctgttg tgtagctacc tgagagagat agccaccgat acgtccgttg
    13801 agcgtttcaa tctttttgtc gagttcggaa atgtgtgtgg tctgcaactg catgacgtgt
    13861 gcgttggtac ggtccacaac agcggtattc atcaccgttt ctttgggata gggtttcttc
    13921 tccagaatgt ccatagccag ttgcagtacc ttatcgccat tggtcggata gataaaggtg
    13981 gcatccagca cactgtccag taccagttcc agtccgtttc ccttacccgg caaggcatct
    14041 atgccgacaa aaatcatttc cttctcccgc cctgccatct ttgctgcctg ataggcaccc
    14101 ggagcgatac ggtcattatg ggcatacaca gcatcaatct taggatgcct ccgaagcata
    14161 ctatccattt ctatctctgc cggaccacgt tcccacgcag catccgcttt atcaatcagc
    14221 tttatatccg ggaatttact gatggcagcc ataaatccct gatgccgttc cattgcagga
    14281 gtcgaaccgc tcaatcctgt cagttctact atatttccct tccctttcag actggaggca
    14341 atatagtttc ctaccgaacg accgatttca taattatcgg ctccgatata ggcagtatat
    14401 ttatccgaaa gaatcttccg gtctacaaga ataacgggga tgcctttctg ataagcttct
    14461 tctacaatcg gagtcatagg agcagcttcg ttagcggaaa taatcagcag atcgactcct
    14521 tcgtccataa aataatggac atcttccgcc tgcttactgt tatcatcccc tgccgaacgg
    14581 atttccaccg aaacaccatt ataaaacatc gcttcccgaa gaatctcatc attcatctta
    14641 tgtcgccatg aatcatcgct gcattgagcc accccaatac gaaaacgggg tgtatcctgc
    14701 cggcaagccg tcatcccgat taaaccaaac agcaccagca tccacttcag atatctcatc
    14761 gtcttcatcc atctcatcat ttcatagttc tttctgtaat ccaattaaga acaaaaataa
    14821 gaaataatac tgtaaagttc tctaacttca gctatttatt attctaaaaa gaaggaaagc
    14881 agtcctcttt cagaccatcg gaaagtatta acaaaagtat aaagcgtaaa acaaacactt
    14941 aatcaatgtt ataaaacata gcgttttact tggataattt gcagatttca cagaagtccg
    15001 tatctttgca ctgtgttttt catagtatta gatttaaggt taacaaaggt tggagcaagg
    15061 cgttgctcct ttttttatgc tctgaccttt catctaccgg ttagttttca tcccattcct
    15121 tttccagttt accatcaata gtgtagcgtt tccatcgtcc tacacggtga ccattcttat
    15181 attccccaca ttcacgaagc tggtcattct ttacataacg agcttcgaac ggtccgttct
    15241 gccttccgtt cacataggta gaagtttccc aataatcaaa gcggttgctc actatcagcc
    15301 gtcgttcctt gccatgcaat ctgccggcct gataggtagc ttcatatctc aattcaccat
    15361 tttccaaatt atattcacgg tataaaccgt ctttacgatc gttcttcata taatattctt
    15421 tctgccttac cccacttccg ttggcaaatg agacatggag tccatcttct tttccatcca
    15481 gataggtttc aatcatcagc gtatctccgc tttcagcaaa agtagtccaa cgaccattct
    15541 tctttccatt cttataacta cccagtatac gtggcgagcc aaacgtaaac acggacgaat
    15601 attcaccgtc ctgaaaacct tcttcattga aataaacggt ctcatacaaa tcatatgtac
    15661 ctttcagaaa agtatactgt ttgcctacct gcttcccgtc cttgtaatta tgctctttcc
    15721 gcaaagtacc gtcagattcg tacgacagtt gcttcccgtg ctctttcccc atccggaagt
    15781 ttctttcact ttccactttt ccggtagtaa agtaactttt gctcgtaccg tccagcttac
    15841 cttccttata ggacttttct tctttcagct taccgtcaaa cttggagtta atcttgaaga
    15901 ggccatcctt ccgcccttct ttataacttc cttccgttat taatatattg tccacatatt
    15961 ctttgtatcc gccatcataa aaaccatctt taaaagatgc cagcacatag gcggaatgat
    16021 aaccatctat gatgcgatgt tcgccattca atgctttttc cgttttcagt tcctgaaaca
    16081 acagtctgcc atcgcctaca ttaacaacag atacctgatc gatcttatat tccttttgcg
    16141 caaacaaagg aagagcaaga tataaaaaca aaaatacgtt ccagcttttt gatctgagga
    16201 agttcgaaat gtgtttcata aagtagtttt ctctttttga tttattattt aaaaacctgc
    16261 cgcaaagata ggcaatcggc ttataaaaca aggcaagaaa gagggggaca attagaaaaa
    16321 agaacatctg ttattatcat tctaataatt aacagattaa gtagtaaatc aaaacacagg
    16381 gaagggggac atttactgaa ataagaaaca gaaaagaaga tgtgtcaaaa gcaactaaat
    16441 tcccctcctt caggaaggag gagagtttag ttgcttttga cacatttaca tttgcagtat
    16501 taaatatcac aacaaaatat aagtgtat
//
