LOCUS       c00050_gnlPro..        13344 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGDIBNIP_134.
ACCESSION   c00050_gnlPro..
VERSION     c00050_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 10:27:51
            Original ID  :: gnl|Prokka|CGDIBNIP_134
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13344
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13344
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9795:12739]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9796..12739
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13344
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13344
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             3..185
                     /locus_tag="ctg50_1"
                     /transl_table=11
                     /translation="DLSASYNIGARYFIRELLKPLPATERSLLEAKVPPVKRRTSCVYA
                     DLRELHLQMEILKVA"
     CDS             1009..2895
                     /locus_tag="ctg50_2"
                     /transl_table=11
                     /translation="MNIIFTSNKETYKNIRQGTEILLSESDIFTENIELSVEFQDRPEI
                     AVSKNGNQIHVICREAAHYYRALNYVLHHMEDKAFQYQEHIYFERNGLMLDCSRNAVFT
                     VEKVKFLIRILAKLGMNVLMLYTEDTYEVKSEPYFGAYRGKYTRDEIKEIDTYAAMFGI
                     ELVPCIQTLAHLHNALKWPEMSEIRDSADILQPGKEETYQFIEKLLISVKENFSTSRVH
                     LGMDEAVMLGLGNSLRENGYKEGSLLIREHCDRVMDICKTLGLKPMIWSDMYITANTRG
                     GYYDVPENADCSQWEKPDRNLGLVYWDYYHDDIRDYEKMLDIHEQLSDNIIFAGGSWIW
                     NGISPNYSKTFACTNAALGACKEYDMKEVLCTAWMDNGAETPVDALLPGVALFAHLGFH
                     KEYDESILKEEFKNCTGGELDDFMELDRFDSLFLNEKGNQEAQNPSKYLLYQDPMLGIF
                     DYHVKASGTDIKAYYQEIYSRMSENCTKSAKYGLVFSFYEKLAAVLAGKADLGVRIKDA
                     YDREEKEILKEISQNEIPDIICNLEEMKRIREEIWMTDAKPFGYELLDVKLGGVITRLK
                     STGHRIDDYLNGKVSRLEELEETRLPYFTGEMDKRENRWDRIISGCDLNDTI"
     CDS             3254..4102
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_3"
                     /sec_met_domain="ATP_bind_3 (E-value: 6.8e-08, bitscore:
                     21.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLEHLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIA
                     ITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKI
                     GDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLREAKLTKAEIREYSKELGL
                     PTWDKQSFACLSSRFVYGETISEEKLGMVENAEQLLLDYGFHQVRVRIHGSLARIEIMP
                     EEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLRGKN
                     E"
     CDS             4099..5886
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M24"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_4"
                     /sec_met_domain="Peptidase_M24 (E-value: 4.2e-43, bitscore:
                     136.5, seeds: 437, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKERITALRARMKETGIDAYLIPTDDFHGSEYVGEYFKCRKYI
                     TGFTGSAGTAVIMQDMAGLWTDGRYFIQAADQLEGTGITLFKMGEPEVPTVHEFLKKNL
                     TQGRCLGFDGRTVSAKEAAELEKMLDENGVSLSVDHDLAGDIWENRPVLSCEPVTELDI
                     KWAGESRADKCARIRKAMEKKGADLFVLTSLDDIAWLLNIRGGDIHCCPVVLSYLVMTK
                     TEIRLFANEKAFQTDVLEALEKDGVTLFPYDSIYEYVKTFKKDKKVLLCKKKVNSRLVS
                     NIPADTRILDEENLTLLPKATKNPVEVENERIAHIRDGVAVTKFIYWLKKNVGRIPITE
                     LSAAEKLYEFRSEQEDFIDNSFDPIIAYGKHAAIVHYFATPETDIPLEPSGFLLADTGG
                     HYKEGTTDITRTVVMGPTTEEEKKYFTAVLRGTLNLGAARFLHGCTGVNLDILARQPLW
                     EMGEDFKHGTGHGVGYLLNVHEGPNSFRWKIVPGGNAVLEEGMITSDEPGYYREDGFGI
                     RHENLMVCKKAEKTEYGQFMCFEFLTMVPFDLDGVVPELMSVRERNLLNDYHAQVYEKI
                     SPYLNEEEKEWLKDATRAI"
     CDS             complement(5974..7740)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     286.7; E-value: 2.2e-87)"
                     /gene_kind="resistance"
                     /locus_tag="ctg50_5"
                     /transl_table=11
                     /translation="MSRSTIKDPAKSKSSETFFKVLRFIGRYRFLLIFSIILAAVSVIL
                     QLYVPILFGNAIDQVIAQHQVNFEMMWYYLSRILVMVILSSAATWLMNVINNRMTYQTV
                     KDIRAKAIRHIQVLPLSYLDGHSTGDIISRIIADTDILSDGMLLGFTQLFSGIVTIIGT
                     LIFMFSKNFWITLMVIVLTPVSFLVAKFISSHTFQMFRKQSDARGRQTALIEEMIGNQK
                     VVQAFGYEEKSSERFAKVNEELQECSLKAVFYSSLTNPSTRFVNNIIYACVALVGAFII
                     PGGRLTVGGLSVLLSYANQYMKPFNDISSVVTELQNALACAGRIFDLLEEEPEVAEASE
                     TLKDVKGEVDIKNVCFHYDESKKLIEDFNLHVKPGMRVAIVGPTGCGKSTFINLLMRFY
                     DVNSGSISVDGKPIRDITRHSLRSSYGMVLQETWIKNGTVRDNISIGKPEATDTEIIEA
                     AKLTHSWEFIRRLPKGLDTMLNEDSLSQGQKQLLCITRVMLCLPPMLILDEATSSIDTR
                     TELQIQEAFERMMEGRTSFIVAHRLSTIRNADLILVMKDGSIIEQGTHDELIAKGGFYH
                     TLYNSQFAKVSE"
     CDS             complement(7737..9551)
                     /locus_tag="ctg50_6"
                     /transl_table=11
                     /translation="MRSLAVYLKNYKKESILAPFFKFLEVVFDLIVPIVIAQIIDVGIA
                     NHDNKYIVQRFSILILMAALGLASTITAQFFAAKASVGFATELRQAVYDHVQHLSYTEL
                     DTLGTDTLITRLTDDVNQIQNGLNMGLRLLLRSPFIVLGSMVMAFTIDFKCALVFAVAI
                     PFLFLVVFVIMFLSIPLFKKVQGKLDTVTGLTRENLTGVRVIRAFCREKEAVAEFDTRN
                     QELTKLNLFVGKLSALLNPVTYVLINIATVILIQKAGVEVNLGGMQQGQVVALYNYMAQ
                     MIVELIKLASLIITLNKSAACAGRVADILKVKSTMDYPSSSTYSAQISKDLATATADAS
                     LSENAIVFNDVTFEYSKAGAPSLSHISFSVKKGQTVGIIGGTGSGKTTLVNLISRFYDA
                     SKGTVLLDGQNIENYTRSDLRSRIGVVPQKAALFKGSIRDNLKWGREDASDEDLWQALT
                     TAQGKEVVEGKPGQLDFMLEQNGKNLSGGQKQRLTIARALVKKPEILILDDSASALDFA
                     TDAALRKSLNRLDWKVTTFLVSQRSSSIQQADLILVLDNGTLAGKGTHAELLRTCDTYR
                     EIYFSQFPEERARYSSVSAGNIMKEVTV"
     CDS             9796..11067
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_7"
                     /sec_met_domain="HGD-D (E-value: 1.9e-56, bitscore: 181.2,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIETFGHYVENLTDKKPQSARRLLKTGWEAQNLKFRYMQDKRL
                     MPADRHLANLMMDTMLRPIQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCYLSASKA
                     ERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTFRTLADF
                     YQVPVFAIDVPWNQTTENVQYVADQLKDLKIFLEKNTGKTISEDRLKERLACSKRTLEN
                     YKKYQQMRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLEDIKKAPAAKGKHIY
                     WMHTIPFWSDVVRQELCFSEKAQIVGCELAETCEPDFDPENPFEAMAERMVYHSLNGSA
                     LRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDGDGCDRS
                     HGGEGQTSTRLGAFLEMLGGAENE"
     CDS             11060..12739
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_8"
                     /sec_met_domain="HGD-D (E-value: 1.1e-17, bitscore: 53.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 7.4e-66, bitscore:
                     211.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTYYVCKYTPIELLESLGGECENFNHMPEGFDLADQVSHPNIC
                     GFGKTLLEGVMEGKIKELVLVSCCDTIRSVYDILLESGKLDFLYILDVLHCDSACSRER
                     MAVQLKGLAKAYAQYKGTEFDAGKFRAAFHAQEKITKSHIAVLGARMGQELFEMTSKAM
                     PLPVENDTCVHNRSVGNILPPEGASFDELMDWYAGEILGQIPCMRMMDPTGRKKLYNDP
                     SVAGIIYHTVKFCDFYSFEYAEIKNHTDVPLLKIESDYTIQSSGQLLTRLEAFAESIQP
                     ETLEQTIDGDTKGERKMGKGYFAGIDSGSTSTDVVILNKDHEIVTSIILPTGAGAAIGA
                     DRALAEALKEAGLQREDIDALVTTGYGRTAIKNGDKSITEITCHARGAHFLNPEVRTVI
                     DIGGQDSKVIRLDENGAVANFVMNDKCAAGTGRFLEMMARTMEMNLDQMSECGLEFKED
                     ITISSMCTVFAESEVVSLIAQNKATDDIVHGLNKAVAVKTAALTRRVGGEEKYMMTGGV
                     SKNKGLVKTLEEKLGTKLVISDKAQLCGALGAALFAADMADV"
ORIGIN
        1 gtgacctgtc agcatcctat aatatagggg cgagatattt tataagggaa cttttaaaac
       61 cccttccggc aacggaaagg tctttactgg aggcaaaagt ccctcctgta aagcgtagaa
      121 cctcatgtgt ttatgctgac ttaagagaac ttcatctgca aatggagatc ttaaaagtag
      181 cataaacaca ggcagatata cagcggatta cctgtaatgt gggaacctgc cgtatccggc
      241 atggaaaaag cacataactg tgcagaccta agttacaggc gtatccgccg atattcagtc
      301 tgacgcctaa agcgtctgga agcacgcgac ttcagtcgtg tgaggataaa gtttttaatt
      361 cacgataata aatgcactgg attgattgca gtattttatg gaatcgatat aaatatcagc
      421 agtccatcac agcagtatat aagcagtaaa tcttgaaaaa ggtttgctgc tttttttgcg
      481 ctcattcccc tgtgagctta tttgcttaaa ggggaatctg atccatatac ttctagcata
      541 gacttgtaat tacctgggtc tgtttggata aagttgattt tatatagtga acatttaact
      601 tcgtttggaa aagttgtgtt ttaacagggt gagatgctga cagatgataa ttaaagtttc
      661 tgatgagatg ctggttgggt gatataaaaa gataaaactg cagaaaatag aaaatttgct
      721 gttccttgta aaagatataa cattttgtgc atgttttgta ttatatcgtt tatgtgaatt
      781 tgagataaac agagttataa ttgtatcaat aaaactctaa agtaatgatt tctatcttat
      841 aattattcca atgaaaatgg gaaactgcag gaattgatgt caatttggct aataaagcat
      901 tgggggctgg ttacaaacct gtattgacgg agattatgta caggggagat acaagacagg
      961 ataacgtgct gctgagaaga gtaaaattct aaggagaaag gaatattaat gaacattatt
     1021 tttacatcca ataaagaaac atataaaaat atcaggcagg ggacagaaat attactcagt
     1081 gaaagtgaca tttttactga aaatatagaa ttgtctgtag aatttcagga cagaccggaa
     1141 attgcggtaa gtaagaatgg aaaccagatc catgtgatct gccgtgaagc agctcattat
     1201 taccgtgcat taaactatgt attgcatcat atggaagata aagcattcca gtatcaggag
     1261 cacatttatt ttgaaagaaa cggtctgatg ctggattgtt ccagaaatgc tgtgtttaca
     1321 gttgaaaaag tgaaattcct gattcgaata ctggcaaagc tgggaatgaa cgtgcttatg
     1381 ctttatacag aagatactta cgaagtaaag agtgaacctt attttggagc ctatcgtgga
     1441 aaatatacca gagatgagat aaaggaaatt gatacatatg ctgctatgtt tggaatagaa
     1501 ctggttccat gtattcagac actggctcat ttgcacaatg cccttaaatg gccggaaatg
     1561 agtgaaatcc gtgattccgc tgatattctt cagccgggga aggaagaaac ctatcagttt
     1621 attgaaaaac ttctgatttc agtgaaagag aatttttcta caagcagggt acatcttgga
     1681 atggatgaag cggttatgtt gggactggga aattccctga gagaaaatgg atataaagaa
     1741 ggttctctgc tgatcaggga acattgtgac agagtcatgg atatttgtaa gacactgggg
     1801 ttaaaaccga tgatatggag tgatatgtat attactgcaa acacgcgtgg tggttattat
     1861 gatgtgccgg aaaatgctga ctgctctcaa tgggaaaaac cggacaggaa tttagggttg
     1921 gtatactggg actattatca tgatgatatc agggattatg agaaaatgct ggatattcat
     1981 gaacagcttt cagataatat tatatttgca ggcggatcat ggatatggaa tggaatttct
     2041 cccaattact ccaaaacttt tgcatgtacc aatgccgcac ttggggcatg taaagaatat
     2101 gacatgaaag aagttctgtg tactgcatgg atggacaacg gggcagagac tccggtagat
     2161 gcgttacttc cgggagttgc cctttttgca catcttggtt ttcataaaga atatgatgag
     2221 agtatcctga aggaagagtt taaaaactgt acaggagggg aattagacga tttcatggaa
     2281 ctggaccgtt ttgattcctt attcctgaat gaaaaaggga atcaggaagc tcagaatccg
     2341 tccaagtatc tgttatatca ggatccaatg ctgggcatct ttgattatca tgtaaaggca
     2401 tcaggtacag atattaaggc atattatcag gaaatataca gccgtatgtc tgaaaattgt
     2461 acgaaatcag cgaaatatgg acttgtgttt tctttctacg aaaagctggc agctgtactg
     2521 gctggtaaag ctgatctggg agtacgtatc aaagatgcct atgacaggga agagaaagag
     2581 atactaaaag aaatcagtca gaatgaaatc cctgatatca tctgcaatct tgaagagatg
     2641 aaacggatca gagaggaaat ctggatgaca gatgcaaagc catttggcta tgagctgctt
     2701 gatgtgaaat taggtggagt gatcaccaga cttaaaagca caggacaccg gattgatgat
     2761 tatctgaatg gaaaggtttc cagactggaa gaactggaag agaccaggct tccatatttt
     2821 actggtgaaa tggataagcg tgaaaaccgc tgggatcgga ttatcagcgg atgtgattta
     2881 aatgatacga tctgaacaat ataaatcatg aagggatttg atcttcaaat ggaaattatg
     2941 ttagttctga taattgctat atttacagcg atttttttca gatgcatttt tgaatggacg
     3001 ataaattcaa gtaagtgtgc cggaataaaa ctttttacac tttgggtatc cgtatattct
     3061 cagtaataca cttcgcaata tgaaaaataa gttgctgaac agtcatcacc tatattataa
     3121 tgaagctata acaccttttt aaataataca tttgagacag ttcaactttc acgctctgtt
     3181 aagccggatc aatatacatt atttacgagg agtgctacag gtacaataaa aaacggacaa
     3241 gaggcagact gatatggaaa ataaactgga acatttaaaa gaatatctga agggacttgg
     3301 cagtgtagca gttgcttttt caagtggagt ggattctaca ttcttattaa aagtagctca
     3361 tgatgtgctg ggtgataagg cgattgcgat tacggctcaa tcctgttctt tcccgaaaag
     3421 agagttgaat gaagcgaagg cattctgcga gaaagagggg attcagcatg tgatctgcca
     3481 gtctgaggaa ttggagattg aaggattttc aaagaatcct ccgaacagat gttatttatg
     3541 taaaaaagaa ctgtttgaga agattggcga tattgcaaaa aagaatggga ttgaatatat
     3601 tgcagaggga tcaaatatgg atgataacgg cgattacaga ccaggtctga tcgccgtaaa
     3661 agaacttgga gttaagagcc cgctacgtga ggcgaagctg acgaaagcgg agatcagaga
     3721 atactcaaag gaactggggc ttccgacttg ggacaaacag tcatttgcct gtctgtcctc
     3781 caggtttgtc tatggagaga ccatcagtga ggaaaagctt ggaatggttg agaatgcaga
     3841 gcagctttta cttgactatg gattccatca ggtacgtgtc cgtattcacg gttcacttgc
     3901 aagaattgag atcatgccgg aggaatttcc gaaacttctg gaaaaaaatg tccgagagga
     3961 tattgcaaag aaatttaagg agtatggatt cacttatgtg accatggata ttctgggata
     4021 tcgtatggga agtatgaacg aaacacttgg cgaaaatgac aaaacgactg cagatagcag
     4081 ccttaggggt aaaaacgaat gacagtaaaa gagagaataa cagcacttcg tgcacgcatg
     4141 aaagagacag gaattgatgc atatctgatt cctacagatg attttcatgg ttcagaatat
     4201 gtaggtgaat atttcaaatg cagaaaatat atcacaggat ttaccggttc tgcaggcact
     4261 gcggtgatca tgcaggatat ggcaggatta tggacggatg gacgttattt tatccaggct
     4321 gcagatcagt tggagggaac aggaattact ttatttaaaa tgggtgaacc ggaagttccc
     4381 acagttcatg aatttctgaa aaaaaatctg acacagggaa ggtgtctggg atttgacgga
     4441 cgtactgtca gtgcaaaaga ggcagcagaa ttggagaaaa tgctggatga aaacggtgtg
     4501 tctctcagtg ttgatcacga tctggcaggt gatatatggg aaaaccgtcc ggtactttcc
     4561 tgtgaaccgg ttacagagct ggatataaaa tgggcaggag aatccagagc tgataaatgc
     4621 gcaagaatcc gcaaagcaat ggagaagaag ggtgcagatt tatttgtact gacttctctg
     4681 gatgatattg cctggctgtt aaatatacgt gggggagata tccactgttg tccggtggtt
     4741 ctttcttatc ttgtaatgac aaaaacagag atcagacttt ttgcaaatga gaaagccttt
     4801 cagacagacg tactggaagc gctggaaaaa gatggtgtga ccctttttcc ctatgacagt
     4861 atctatgagt atgtgaaaac atttaaaaag gacaaaaaag ttcttctctg caaaaagaaa
     4921 gtcaacagtc gtctggttag caatattccg gcagacaccc ggattctgga tgaagaaaat
     4981 cttacacttc ttcccaaggc aacgaagaat cctgttgagg tggaaaatga acgcattgcg
     5041 catatcagag acggagttgc agttacaaag ttcatatact ggttaaagaa gaatgttgga
     5101 aggattccaa tcacagaatt aagtgcagca gaaaagctgt atgaattccg ttcggaacag
     5161 gaggatttca tagataacag ttttgatccg attattgcct atggaaagca tgctgctatt
     5221 gtacattatt ttgcaacacc cgaaacggat attcctctgg aaccatccgg ctttcttctg
     5281 gcagatacag gaggacatta taaagaggga actactgata ttacccgtac tgttgtcatg
     5341 gggccgacta ctgaggaaga gaaaaagtac ttcacagcag ttttgcgggg aactctgaat
     5401 ctgggagctg ccagatttct tcatggctgt accggtgtaa acctggatat tctggcgaga
     5461 cagccgttgt gggaaatggg agaggatttt aaacatggaa ccggtcatgg agtaggatat
     5521 cttctgaatg tccatgaagg acccaatagc ttccgatgga aaattgttcc gggtggaaat
     5581 gcagtgctgg aggagggaat gatcacctct gatgagccgg gatattacag agaggatgga
     5641 tttggaatcc gtcatgaaaa tctgatggtc tgcaaaaaag ctgaaaaaac agagtatggt
     5701 cagtttatgt gctttgaatt tctgactatg gtaccttttg atctggatgg agtggtgccg
     5761 gaactgatga gtgtccggga acgtaacctt ctcaatgatt accatgcaca ggtatatgag
     5821 aagatttctc cgtatttgaa cgaagaagaa aaagaatggc tgaaagatgc tacccgggca
     5881 atctgataaa aataaaaaaa cattttacaa aatcaaaaag aggaacagcc gtgatggaca
     5941 gctgttcctt tttgatttat tatctggttt gttttattca gaaacttttg caaactggct
     6001 gttatataaa gtatggtaaa atccaccttt tgcaatcagc tcatcatgag taccctgctc
     6061 aatgatactt ccgtctttca taacaagaat cagatctgca tttcggatgg ttgaaagcct
     6121 gtgagctacg ataaagcttg ttcttccctc catcattcgt tcaaacgctt cctgaatttg
     6181 taattctgtt cgtgtatcaa tactggaagt ggcttcatcc agaatcagca tcggaggcag
     6241 acagagcata actcgtgtga tacacagcag ctgtttctgt ccctggctta agctgtcttc
     6301 gttgagcatg gtgtccagtc ctttaggaag cctccggata aattcccagc tgtgggtaag
     6361 cttggctgct tcgatgattt cagtatctgt agcttccggt tttccaatcg agatattgtc
     6421 gcggacagtt ccgtttttga tccatgtttc ctgaagcacc ataccatagc tgcttctgag
     6481 agaatggcgg gtaatgtctc tgattggttt gccgtcaacg gaaatagatc cggaatttac
     6541 atcatagaat ctcatcagaa ggttgataaa ggttgactta ccgcatccgg taggtcctac
     6601 aatggcaacg cgcatacctg gttttacatg gagattaaag tcctcaatca gtttctttga
     6661 ttcatcataa tggaagcaca cattcttaat atctacttca ccctttacat ctttcagtgt
     6721 ctcagaagcc tctgcaactt ccggttcctc ctccagcaga tcgaagattc tgcctgcaca
     6781 ggcaagagca ttctgaagtt ctgtaacaac ggaactgata tcattgaatg gtttcatata
     6841 ctggttggca taggagagaa gtacggaaag tcctccgact gtcagtctgc ctccagggat
     6901 aatgaatgca cccaccagtg caacacaggc ataaataata ttattgacaa aacgggtgga
     6961 agggtttgtc aggctgctgt aaaaaacagc cttcagactg cattcctgta attcttcgtt
     7021 aacctttgca aagcgttcag aagatttttc ctcatatcca aaagcctgaa caaccttctg
     7081 gtttccaatc atctcttcaa tgagagcagt ctgacgtcct ctggcatcgc tttgcttccg
     7141 gaacatctgg aaggtatggg aagaaataaa tttggccacc aaaaagctta cgggggtcag
     7201 gacaatgacc atcaatgtaa tccagaagtt tttggagaac atgaagatca gtgttccgat
     7261 gatcgttacg attccggaaa aaagctgggt aaatccaagc agcataccat cggatagaat
     7321 atctgtatct gcgataatac ggctgatgat atctccggta ctgtgtccgt caaggtaaga
     7381 gaggggaagt acctgaatgt gtcggatggc tttggcacgg atatccttta ctgtctggta
     7441 ggtcatgcga ttattgatca cattcataag ccacgtggca gcagaagaga ggatgaccat
     7501 tacaaggata cgtgacaggt aataccacat catttcgaag tttacctgat gttgggcaat
     7561 gacctgatca atggcatttc cgaataggat tgggacatac agctgaagga taacggaaac
     7621 tgctgccagt atgatactga agatcagcag aaaacggtat cttccgatga aacgcagtac
     7681 tttaaaaaaa gtttcgctgc ttttgctttt agcaggatct tttattgttg atctgctcat
     7741 acagtcacct ccttcattat attacctgca gatacagagg agtatctggc tctttcttcc
     7801 ggaaactgag agaagtagat ttcccggtaa gtatcacagg tacgcagcag ttcagcatga
     7861 gtacccttac ctgccagagt accgttatca aggacaagga tcaagtctgc ctgctgaatg
     7921 ctggaggaac gctgggatac cagaaatgta gttactttcc agtcaagtct gttgagagac
     7981 ttacgcagtg ctgcatcagt ggcaaagtcc agggcactgg cactgtcatc cagaatcagg
     8041 atttcaggtt tttttaccag ggcacgggca atggtaagtc tttgtttctg gccgccggaa
     8101 aggtttttac cgttctgttc cagcataaaa tcaagctgtc ccggtttacc ctctactacc
     8161 tcttttccct gtgctgtggt aagtgcctgc cacagatcct cgtcagaggc atcttcccgg
     8221 ccccatttca gattgtctcg gatagagcct ttgaaaagag ctgccttctg cggaacaacg
     8281 ccgattctgg agcggagatc acttctggtg taattttcaa tattctgacc atccagcaga
     8341 acagttcctt tgctggcatc atagaatctg gagatcagat ttaccagagt ggtttttccg
     8401 cttcctgtac caccgataat acctacggtc tgtccctttt ttacagaaaa actgatatgg
     8461 gaaagactgg gggcaccggc tttgctgtac tcaaaggtta cgtcattgaa tacgatggca
     8521 ttttcagaaa gtgatgcatc agcagttgct gttgcaaggt ccttcgatat ctgagcagaa
     8581 tatgtggagg aagaggggta atccatagta gatttcactt tcaggatatc tgccacacgt
     8641 cctgcgcagg ctgcagattt gttcagggtg atgatcaggg aggcaagctt gatcagttcc
     8701 acgatcatct gagccatata gttataaagg gcaacaacct gtccctgctg cataccgcca
     8761 agatttactt ctactcctgc tttctggatc agaataacag tagcaatatt gatcagtacg
     8821 taagtgaccg gatttaacaa agcggaaagc tttcctacaa agagatttaa ctttgtcagc
     8881 tcctgattgc gggtatcaaa ttctgcaact gcctcttttt cgcggcagaa tgcacggata
     8941 acgcggacgc ctgtaaggtt ttctctggtc agtccggtta ctgtgtccag ttttccctgt
     9001 acttttttaa acagaggaat actgagaaac ataatgacaa agacaaccag aaacagaaat
     9061 gggatcgcaa cagcaaaaac cagggcacat ttaaagtcaa tggtaaatgc catgaccatg
     9121 gaaccaagta cgataaacgg acttcgaaga agaagacgaa gtcccatatt taatccgttc
     9181 tgaatctgat tgacatcatc ggtgagtctt gtgataagag tatctgttcc cagtgtatcc
     9241 aactctgtat aggacagatg ctgtacatgg tcataaactg cctgtcttaa ttctgtggca
     9301 aagcccacgc tggctttagc ggcaaagaac tgagctgtga tggtactggc aagaccaaga
     9361 gccgccatta gtataagaat agaaaatctc tggacaatgt atttgttgtc atggtttgca
     9421 atacctacat caatgatctg tgcaatgacg ataggcacga tcaggtcaaa tacaacctcc
     9481 agaaatttaa aaaatggcgc caggatgctt tcttttttgt agttttttaa ataaactgcc
     9541 aatgaacgca ttttaaaaat tccttccttt cgtaaaaaat ctttcctata ttatttcttc
     9601 ctttttttga aaaataatac attcaaaagt gtatcatttg agactttttt gtcaagaaga
     9661 atgtgcaaaa acagatgaac tttggagaaa attcagcttg acttcaaaaa aagatattac
     9721 taaaatattc cgtagcgcta tttgtacgct ggcaactgat aaattattat taccataatg
     9781 aggaagagac agactatgga gattattgag acatttggtc attatgtgga aaatctgacg
     9841 gataaaaagc ctcagtcagc ccgccggctg ttaaaaaccg gctgggaggc gcagaatctg
     9901 aagttccgtt acatgcagga caagagactg atgcctgcag acaggcatct tgcaaatctg
     9961 atgatggata ccatgctgcg gcccattcag aaaccggaag attctgttat tgtaagtatt
    10021 tttacaccct gcgaaatgat gcaggaggtg ggattacatc cctataatgt agaaggattt
    10081 tcctgctatc tttctgcaag caaagcagag agggcatttt tgcagcaggc agagaatcag
    10141 ggaattgcag agacactgtg cagttatcac aagacatttc ttggtgcagc gcagaaagga
    10201 cttctgccaa agcccaaatg tattgtttat accaacctga cctgcgatgc taacctgctc
    10261 accttccgta ccctggcaga tttttaccag gtacctgtat ttgccattga tgtaccatgg
    10321 aatcagacca cagagaatgt acagtatgtg gcagatcagt taaaggattt aaaaatattt
    10381 ctggaaaaaa atacaggaaa aacaatctct gaggacagat taaaggaacg tcttgcctgc
    10441 agtaagcgga ctctggagaa ttacaaaaaa tatcagcaga tgcgtgcaga cagatatgtg
    10501 ccctctgatc tggtcacacc cttgtatgca ggaatgacaa acaatatcct tctgggaaca
    10561 gcagaagaag agaagtatac acagatgctt cttgaagata ttaagaaagc accggcagcg
    10621 aaagggaaac acatttactg gatgcatacc attccattct ggtcggatgt agtgcgccag
    10681 gagctttgct tcagtgagaa agcccagatc gtaggatgtg aacttgcaga aacctgtgag
    10741 ccggattttg atcctgagaa cccctttgaa gcaatggcag aaagaatggt atatcattca
    10801 ctgaacggaa gtgcccttag aaggattgaa gccggtatcc gccatgcgaa acaggcagga
    10861 gcagacggtg ctgtgtggtt tggacattgg ggatgtaaac atacgcttgg tgcggcacag
    10921 cttgcaaaga agaagttcga ggaagccggt ctgccccttt tgatcctgga cggtgacggg
    10981 tgtgatcgaa gccatggagg agaaggacag acttccacca ggctgggagc ttttctggaa
    11041 atgctgggag gtgctgagaa tgaataaaac ttactatgtc tgtaaatata ccccaattga
    11101 acttctggaa tctcttggcg gggaatgtga gaactttaat catatgccgg agggatttga
    11161 cctggccgat caggtttcac atcccaatat ctgcggtttt ggaaaaacac ttctggaagg
    11221 agtcatggag gggaaaatca aggaacttgt cctggtgagc tgctgtgata ctatccggag
    11281 tgtctatgac attctgctgg aaagcggcaa gctggatttt ctctatattt tggatgtgct
    11341 tcactgtgac agtgcctgta gcagagagcg tatggctgta cagttaaaag ggctggcgaa
    11401 ggcttatgca cagtacaaag gcacagagtt tgatgccgga aaattccggg ctgctttcca
    11461 tgcacaggag aaaatcacaa agtcccatat tgcagtgctt ggcgccagaa tggggcagga
    11521 attatttgaa atgaccagca aagctatgcc tcttcctgta gagaatgata cctgcgtgca
    11581 taaccgttct gtgggaaata tacttccacc ggagggtgct tcttttgatg agctgatgga
    11641 ctggtatgca ggtgagattc tggggcagat tccatgtatg cgtatgatgg acccgacagg
    11701 tcgtaagaag ctttataatg atccgtctgt tgcggggatt atttatcata cagtgaagtt
    11761 ttgtgatttt tacagcttcg aatatgctga gatcaagaac catacagatg tacctctttt
    11821 aaaaattgaa tcagattata ctattcagag cagcggtcag cttcttacca gactggaagc
    11881 ttttgcagag agcattcagc ctgaaacact ggagcagacc atagatggag acacaaaagg
    11941 agagagaaaa atgggaaaag gttatttcgc agggattgac agtggttcca ccagtacaga
    12001 tgtggtgatt ttaaataaag accatgagat tgtgaccagt attatcctgc ctacaggagc
    12061 aggagctgct atcggagcag atcgtgccct tgcagaagca ttgaaggagg ccggattgca
    12121 gagagaagat attgatgcgc tggttactac cggatacgga cgtacagcta ttaaaaatgg
    12181 tgataagagc atcacagaga tcacctgtca tgcaagaggt gcgcatttcc tgaatccgga
    12241 agtccgtact gttattgata ttggcggaca ggacagcaag gtgatccgac tggatgagaa
    12301 cggtgcagtt gcaaactttg ttatgaatga caaatgtgcg gcaggaaccg gacgatttct
    12361 ggaaatgatg gcacgtacca tggaaatgaa tctggatcag atgagcgaat gtgggctgga
    12421 attcaaagaa gatattacaa tttccagtat gtgtacagta tttgcagaat cagaagttgt
    12481 atccctgatc gcccagaata aggcaacaga tgatattgtc catggcttga ataaggcggt
    12541 tgccgtaaag actgccgccc ttaccagacg tgtgggcggt gaggagaaat atatgatgac
    12601 cggtggtgtt tctaagaata agggcctggt aaagacactg gaagagaagc ttggaacaaa
    12661 gctggtgatc agtgacaagg ctcagctttg cggtgcactt ggcgcggcac tgtttgcggc
    12721 tgatatggct gatgtataaa aattatttaa atatccaggg attttacaag gtggaaatct
    12781 ctggaatttt tatacttttt ttataaaagt ttaattttct attgacgagt tcgaatttaa
    12841 gagctatagt ataccacagt aacagcaaat taacgaggtg aagtttgcag gaaagaggaa
    12901 gccacacaaa aggctatacc cgccgaagga gtaaaactct caggttccct ggatgcaggg
    12961 aagaactgca aatggatcgt ttctctggag acacccgtta gatcgggggc cgaaggtgca
    13021 aataacacga attatcaata gctacccaca aatggttatc tgattcgtgt cttgaatctc
    13081 tcaggcaaaa ggacagagga tgctttatca tccccgctga ttcatatgaa ctatatgaac
    13141 agtattttct gaacttctga tttttgaaac ggtctgttat tactttgttt cccagctgta
    13201 caatatatta cactttttaa taggtaattg cgaaacaagt tcgcaatctt gattgaaaac
    13261 aaggatagaa tcctgcaatg caggattcct ggaatggaag gtggcagtca ttcatttagg
    13321 gcatgacaaa aaggcttcat agtt
//
