LOCUS       c00063_gnlPro..        15785 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGCANGJP_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 09:23:41
            Original ID  :: gnl|Prokka|HGCANGJP_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15785
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15785
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[672:5785]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      673..5785
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15785
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15785
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             673..1896
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.8e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFL
                     AGGGVVISRAHEIFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVS
                     NCDVLFSIGTRFNDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITK
                     MNEYVQECSTDKWLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQH
                     QMLVSQYAEITEGKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQE
                     LATAVLEELPVILCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYT
                     PDFIRLAESYRAKGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGT
                     LEDMIMDC"
     CDS             1914..2423
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1.6e-22, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(2492..3748)
                     /locus_tag="ctg63_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKMEEP"
     CDS             4511..5224
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             5426..5785
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_5"
                     /sec_met_domain="ALS_ss_C (E-value: 6.5e-23, bitscore:
                     72.2, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSKEDKVELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVV
                     RGGSVGIESISMMER"
     CDS             6160..6795
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPG
                     LSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIV
                     CIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQ
                     GIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIISKALSVALKRA"
     CDS             6902..7867
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPNRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(7939..8181)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MERLIFHIDVNSAFLSWESARRVSQGIPEKMWPLPVRNLLFLGKA
                     SEQKLLNQGIRTIGDLARERETNVQLWLGEKPEHR"
     CDS             complement(8197..9381)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.3; E-value: 1.8e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg63_9"
                     /sec_met_domain="MFS_1 (E-value: 1.1e-24, bitscore: 78.3,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(9695..10459)
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             complement(10453..10641)
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNNEVE
                     ERQADSRSIPNEMEILC"
     CDS             complement(10786..11499)
                     /locus_tag="ctg63_12"
                     /transl_table=11
                     /translation="LLVLEERIVMKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYS
                     GSGISAISSVPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAF
                     SELLDVNEAWINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEI
                     IKVKYSKIKVSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKH
                     FRFVNFTQHCSLHVQ"
     CDS             complement(11641..13059)
                     /locus_tag="ctg63_13"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVRPGGHILVDDGLVDLEVQDISGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILAVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(13313..13843)
                     /locus_tag="ctg63_14"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGGET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
     CDS             complement(14175..15680)
                     /locus_tag="ctg63_15"
                     /transl_table=11
                     /translation="MGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEAGQTYWQI
                     LPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPDEVDYEKI
                     YKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEWTKWAEDI
                     RLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIPIYVAMDS
                     ADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQWWISRMS
                     YCFRLYDVVRIDHFRGFDEYFSIPYGDKDARGGHWEKGPGIDLFRKIEQALGWKQVIAE
                     DLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYTGTHDNET
                     IVGWWKSITAAERKLARDYLCDHATPEEELYKCFISLIMRSAARVCVIPMQDYMGLDNR
                     FRMNKPSTVGTNWKWRIKKRDLTKKLQKEIYDVTLRYGRKNWD"
ORIGIN
        1 aaaagcctca gcgtagcccg ctacgcctgc gtttttatac cagcacactc gaatccgcat
       61 cctacgcgat tggtataatt atttacgaaa cgatgtacta gactccgaaa ccgcacccga
      121 aaacaaataa atttccgagc gtccccatcc acatacccaa aggaggttta cccaaatatg
      181 aaacaaatat ccggcaacaa actcttagtc aaagccttaa aagaagaagg cgtagaatac
      241 ctcttcggct accccggcgc ctgtaccatc gacatcagtg acgaactcta caaacaggac
      301 gacgtcaaaa tcatcctccc ccgtcacgaa caggcccttg tccacgaagc cgacgcctac
      361 gccagaacca ccggcaaagt cggcgtatgt ctggtaacca gcggtcccgg agcaaccaac
      421 cttgtaacag gacttgcaac cgccaactat gacagcgtac ctcttgtatg cttcaccggc
      481 caggtagccc gccacctcat cggcaacgat gcattccagg aggtagacat cgtaggaatc
      541 accagaagca tcaccaaata cggcgttact gtccgcagac gtgaagacct tggcagaatt
      601 atcaaagaag ccttctacat tgcccgcacc ggccgtccgg gacctgtcct tatcgacctt
      661 ccaaaggacg taatggcaga actcggcagc gctgaatatc ctaaaaatgt aaatatccgc
      721 ggatacaagc ccaacacaga tgtccacatc ggccagctca aacgtgccat caaactttta
      781 aataaagcaa aacgtccctt attcctggca ggcggcggtg tagtaatctc ccgcgcccat
      841 gaaattttcc gggaagtagt ggaaaagaca aaagtaccgg ttgtcacaac cgtaatggga
      901 aaaggctcta tccccacaga ccatccgctc tatatcggaa accttggcat gcatggtgcc
      961 tatgcagcaa atatggcagt cagcaactgc gatgtgctgt tctccatcgg aaccagattc
     1021 aatgacagaa tcaccggaaa acttcatgaa tttgcaccac atgcccagat tatccacatt
     1081 gatattgata cagcatccat ttcccgaaac attcaggtgg atatccccat tgttgctgat
     1141 gcaaaagagg ctatcaccaa aatgaacgaa tacgtccagg aatgttcaac ggacaagtgg
     1201 cttaacctga tcaaaaactg gaaagaagag catccgctta aaatgcgtcc aaatgatctt
     1261 ttaagtccga tggatatcct gaaagagatc aacgaacagt ttgagaacag tattatcgta
     1321 acagatgtag gacagcatca gatgcttgtc tcccagtatg cggaaatcac agagggcaaa
     1381 cagatgatca tgtccggtgg tctgggaaca atgggctatg gtcttccagg cggcatcgga
     1441 gccaaaatcg gaaatcccga cagacctgtc atcgttatct ccggtgacgg cggtgtgcag
     1501 atgaacattc aggagcttgc aactgcagtt ctggaagaac ttcctgttat cctgtgcatc
     1561 tttaacaatg aataccttgg aatggtacgc cagtggcaga agcttttcta cggcaaacgc
     1621 tatgctatga ccaatctgcg cgcaggagca ctttcccgcc gcactgaagg catggaatat
     1681 ccacagtaca caccggattt catcagactt gcagagagct acagggcaaa aggaatccgt
     1741 gtcacaaaga aagaggaaat tgcagcagcc ttcgaggaag caaaaaagaa cacaaaggca
     1801 cctacagtaa ttgaattcat cattgaccct gaggaaatgg tttatcctat gatcaaacca
     1861 ggcggaactc tggaagatat gattatggac tgttgatcag gaggaaaatt attatggata
     1921 aaggaatgaa aaaaagatgg atttctctct atgttgagaa ccaggtaggt gttctgtcca
     1981 aaatctccgg acttttctcc ggaaaaagct acaatctgga cagtcttact gtaggaacca
     2041 ccgaggaccc cacagtatct cgaatgacga tcgcaactgt cagtgatgat gaaacttttg
     2101 agcagatcaa aaaacagttg aaccgtatga tcgaggttat taaggttatt gatttcacag
     2161 acgtatttgt ccgcatgaaa gagattctgt atattaaggt ttttaactgt tccaaagaag
     2221 ataaggttga actgtttcag attgccgaaa ccttcaaggc aaaggtcatt gactatggca
     2281 aagacagcct gctcctggaa tttgtccaga cagcaaccaa gaatgacgca gtagtgaaac
     2341 tgatcaagga agaatttcac agaattgaag tggtacgtgg aggaagtgta ggaatcgaat
     2401 ctatcagtat gatggaacga taaaactttt tctgaaattt ttataaaggg aggattgtcg
     2461 cattgttctt aatgctcagt cctcccttta cttacggttc ttccatcttt tcgtttttca
     2521 tctgtgcttt cgcttttcgc ccaatccgtg cattgctgtt cataatactg gcacgggtga
     2581 tcttatcatt tccaaatttc atccggatct catccatagc tgcatccagc tttctgtggc
     2641 gttctttatt ttctgtatct tcaaacagag acatctgttc ataagtgcca tctgtaaggc
     2701 ctgtcagtgc cacaccaatc agacgtagcg gctgtccttt ccagaactct ttaaaaagtc
     2761 ttgtagcatt tatataaatt tcatctgtaa gatctgtagc attttccagc tttgtctggt
     2821 gtgaacggtt tctgaaatcc aaagtacgga aagtcacgga aatacagttg catttcttat
     2881 cttttctgcg cattctggtt gccagaacat cacactgctc caaaagtatg ggaaacacct
     2941 gctctatgga agtaatatca tcgttaaaag tagtttccac gctgaaacct tttgcctcat
     3001 caggcactgc ttttacaggg gaatcatcga tacctctggc atattgccat agctgatgtc
     3061 ccgttttttc cccaagccag tactgcacat tggatgctct ttctcttgcc agatcaccga
     3121 tggtacggat tccctgattc agaagcttct gctcggaagc ttttcccaga aacagcagat
     3181 tacggatagg aagaggccac attttctccg ggatttcatc cgggaacaga gtgtgtactc
     3241 tgtccggctt ttgaaaatct gatgccatct ttgccaaaag cttattggta gaaattccta
     3301 catttactgt gaatcccagc tctctgtgaa tcttgtcttt cagctcatga gcagcagcta
     3361 cagggtcagg atagatcaga gaagtacctg tcatatccag aaatacctca tcaatggaaa
     3421 aagattccat cacaggtgca aaggaagcac agattgcttt aaatgcccgg gaacatttat
     3481 cgtataattc aaaatcactg ggaacgatca ccaaattggg acatttccga agagccatag
     3541 ctactggctc gccggtctgg atcccgtatt tttttgcagg gatagatttg gcaaccacga
     3601 tacctgtccg tttctttgga tctcctccta cacaggaagg aatttctctg agatccggta
     3661 gcccctggct cacccttctg gctgattccc aggaaagaaa tgcactgttg acatcaatat
     3721 gaaaaattaa tcgttccgta cttttcactg ttcttcctcc aatatatgaa ttgcgctctt
     3781 catatctgat gatttcattt taccctgatc tgctctccag ggtaagaacc tcgtttgtcc
     3841 aaaaaagtgt ctttatttgc atcatcttgt ctgagctgtt actgtattta tatttgtttg
     3901 atttcactct gctatcagag ttttgaacaa caacgccgca cttgccatac ggcagtgcgg
     3961 cgtctgtatt tcgctaccgg tcacattgtt cccggtaact ttttttactt aattctgagg
     4021 attcatttcc tctcgatata tacttatcga ttagtcataa agattaggag caatttcttc
     4081 gctgtccata tttgtggaat cataccagta tccagttcag cctccagcca ttcataagag
     4141 aattccggga atggctgatg tttgaaattt ttccatgtta ctcctttctc atgaagtaac
     4201 tgtctacaca taagcaaaca gtgccatcgc tgtcattgat cagcaataag cccccgtgtt
     4261 ttcatatagt tccattatac cttctcattt tcccgaagtc aacataattt aacatgtatc
     4321 agccgtttat ttgtgttgct ttttatttga tttttgttgt atttcagttg tttttatttt
     4381 gtttcctcat tgacatttaa atcctcatct gtcatacttg aatataacga atgtaccatc
     4441 aaacagcagc tttgcatctt ccgtaaggct cttatcatat atagaaaccg ctctggaaag
     4501 gagacaaaca atgtatcttt ctgacatcca cacacattct atcgccagcg gtcacggaac
     4561 cacctgtacc atctctgaca tggcaaaagc agccagcaaa aaaggactga aactccttgg
     4621 gatttctgac cacggcccgg gaactctggc ttccggaact tcttcttatt tcagaagcct
     4681 tcctttttat cccagaaaaa gattcggcat agatattctt tacggagttg aactaaacat
     4741 cctggacagt gcaggacata cagatctgtc agatgaactg ctgaacaacc tggattacgc
     4801 tatcatcagt atgcatcggc agaactaccg ttcaggctct gtatctcaga atacagaagc
     4861 ttacatcaat gcaataaaac atcctgctgt aaaaatactc ggccactgcg acgatacaca
     4921 tttccctgta gattatgaaa cgctggcaag agcagcttta cgggaaaatg ttatttttga
     4981 aataaacgaa gcttccctcg cacccggagg atatcgggga gacacaagag ccaatgccgc
     5041 cagaatcctg tatctctgtc agaaatatca gcttcctgtt attttgtcca gcgacagcca
     5101 cggaaaagaa catgttggag atttcaccta tgccgaagaa ttcgttcacc agctcatgtt
     5161 tccggaaact cttatcctta acaaccagct tcccaaatta aaagttttcc ttcagacacg
     5221 ttaaaagaat gttcctcaaa gggacattct tttattttat gcattgtttt ttgcattgtg
     5281 ttattttgtt tattttctat aatttcttgt caaaaaagac gacattttag tacattttaa
     5341 ttaacaaaac tcacttaacc atttacatat ctcgtgatag atcagtctta ctgtaggaac
     5401 caccgaggat cctacagtat cccgaatgac tatcgcaaca gtcagcgatg atgaaacctt
     5461 tgaacagatc aaaaaacagt tgaaccgtat gatcgaggtt attaaggtta ttgatttcac
     5521 agacgtattt gtccgcatga aagagattct gtatattaag gtttttaact gttccaaaga
     5581 agataaggtt gaactgtttc agattgcaga aaccttcaag gcaaaagtca ttgactatgg
     5641 caaagacagt ctgcttctgg aatttgtcca gacagccacc aagaatgatg cagttgttaa
     5701 actgatcaag gaagaattcc acagaattga agtggtacgc ggtggaagcg ttggaattga
     5761 atccatcagc atgatggaac gctaaatctc ataatcaata ttttttacag gatatagaaa
     5821 cacctctata tcctgtattt attttcaaac atactataaa atattgcagt ttttaatcaa
     5881 atgtgttatt gtttacggga gcgttattcg aaagaaaatg catctgattt ccacatctga
     5941 cagtctggtg gataaagtca tccacttcac agtctggtta aatttgtgag gcgacctgta
     6001 aggcgtctac acaccggaaa cttttaccgg aagatatttc ttgtttcata tcttttgttc
     6061 tgatgtatat ttttcataac gcctgatccc catactctaa actgtctgaa aagcagggga
     6121 cgcattgcgc cgttttatca gaccaaaagg agaattcata tgaacacaac aacaactact
     6181 acaacagctg ccgcaaaaag aagcagcact ctttacatgg tagagctggc tatgatgatt
     6241 gccattattc tgctcatgtc ctttaccccg ctgggctacc ttcgtactcc cggcttatcc
     6301 atcactcttc tcaccatccc ggtagctgta ggagctatca tcctcggacc gaaaggtggt
     6361 gctgtatgcg gacttgcttt cggtgcaacc agcttctata tggctgtcac aggaagttca
     6421 gctttcgctg ccgcactttt taacattaat ccatttggca cttttattgt atgtatcgtg
     6481 gcacgtgtgc tggaaggatg gatcacagga cttattttcg cagcattata taaatcaccg
     6541 gcgaagaaat tttcctatta cgttgcttca ctggcatgcc cgttactgaa tactttcttc
     6601 ttcatgggct ttttatgtct cttcttctac aacacagatt acattcaagg tattgtttcc
     6661 agtcttggag taagcaatcc tgttgtcttc gttgctgctt ttgtgggcgt tcagggactg
     6721 atcgaagcgg gcttctgctt tgtagtggga agcatcattt ccaaggcact ttctgtggcg
     6781 ctgaaacgtg cataatcttt aaaagaacag ccttttaatt ctgctgttcc ggaaggttca
     6841 ctaaaaatcc ctgactacat tgtcactgta gtcaggtttt ttttatcaaa aggagatttt
     6901 tatgtcatta ctaaaagaga tttctattac agagctttca aatttacgca tcggccatac
     6961 ttctgaccat gatgcgaaga ccggtgtaac tgttctttat tttccaaatg gagcaaaagc
     7021 aggctgcgat ataagcggag gcggtcctgc ttccagagaa actcctctca cctctcctgt
     7081 cactgccgac aatcctatca acgccattgt cttgtccgga ggttctgcct atggactggc
     7141 tgctgctgac ggtgtaatga actatctgga atcacaaaat atcggttata acaccggtgc
     7201 agcactggtt ccccttgtat gccagtcctg tatctatgac ctctcttacg gagatcctaa
     7261 aatacgtcca actgcaaaaa tgggcgaaga agcctgccgt caggcatttg caggaacaga
     7321 taccagaacc ggaaatatcg gtgcaggtac cggtgcaact gtgggaaaac tttacggtat
     7381 gaaacaatcc atgaagtcag gtcttggtat tgccgctgta tcagtgggaa atttccagat
     7441 ggccgcaatt gtcgttgtca atgcactggg agatatcttt agtccacaaa atggtcagaa
     7501 aatcgcaggg ctgaaaacgc ctaacagaag cgggtttctg gatagtgtcc acgaattata
     7561 ccgctttatg acacctcatg accagtttac cggcaatacc accatcgggg ctgtgatcac
     7621 caatggggca ttttcaaagg ctgaactgaa taaaattgcc tctatgaccc gctgtgccta
     7681 tgccagatgc atcaatcctg tagcaactat ggctgacggc gattccatct atgctgccag
     7741 cattggcgat gtttctgtag atatcaatat ggcaggaact ctcgccgcag aagtcatggc
     7801 tcaggctatc caaaatgcca tccatacttc ccggatccag gatgaagaat ttctgaaata
     7861 tgtataacag tccgctataa aagcgcagag aaaaagtatc atctctgcgc ttttattctt
     7921 cctgtctgtc ttcatttttc atctgtgctc tggtttttct ccaagccaga gctgtacatt
     7981 tgtttcccgt tcccttgcca gatcaccaat agtacggatt ccctgattca gaagcttctg
     8041 ctcggaggct tttcccagaa ataacaggtt acggacagga agtggccaca ttttctccgg
     8101 tattccctgg cttacccttc tggctgactc ccaggaaaga aatgcgctgt ttacatcaat
     8161 atgaaaaatt aatcgttcca tactttttaa tatatctcaa tcatattttt gcagacttcc
     8221 aatcatctta atccccatta tcatcaacac agggaaaatc agtgccgcaa agattccaag
     8281 tttcagatta tcattcaggg ctcctgaaat catccccaca taggttggtc cggatgagca
     8341 tcccacatct ccagcaaggg caaggagggc aaacaaggct gttccgccac gctttactga
     8401 ggcagccgcc atgctgaagg ttcccggcca cataatacct acagacagac cgcaaaccgc
     8461 acatccaagg attcccaacg caggtaccgg gataaatgcg atcatcagat aggaaaccat
     8521 gcacagaact gcactgtatt gcataaagcg ttccagattg attttatctc caaatttccc
     8581 ataaaatgcc cttgaacttc ccataagaat tgcaaacgcc atgggacctg ccagatctcc
     8641 gatagtttta ttgattccaa agcttttctc agccagagta gaagcccact ggcttaccgc
     8701 ctgctcactg gctcctgcac agagcatcat taacatcaga acccagaaga tttttttctt
     8761 aaaaagctct cccatagtca gccccttttc accctcatcc agcagtggag caatgggaac
     8821 tctggtaaaa aggattccat ttgcaatggg aatcaatgcc cacaccagcg ccatatattt
     8881 ccagtttgca atcccgaaaa tacgaaagaa taatgtagaa agaagtacca ctcccacatg
     8941 tccccaacag taaaaggaat gaaggagact cattgctttt tccttattat ctgtagggca
     9001 ggcttccacc acaggactta ccaacacctc cagcaatccg cctccgatgg catagatcat
     9061 aactgcaatg agaagtccca caaacggatc tcccaggcac tccggcaata ctgtgagcaa
     9121 aatcagacct gcagccgcca ttgcatgtgc caggatcata gatgcacgat aacctattct
     9181 gtccacaaat ccaatcgatg ccagatctac cagcaactgg atcccgaaat taaatgtaac
     9241 cagaagtgtg atcttctgca gcgaaatccc gtaactgccc tgaaatgtca gaaacagcag
     9301 aggaacgaaa ttgttcacaa tggcctgcac tacatatccg ataaaacagg cctgcactgt
     9361 tctgttgtaa tttgttttca tccgatgtta tatcctccaa tctgaaattt attaagctga
     9421 catcattcag acattgatcc accaaacttc tatatctcca cagttctaat agatttctat
     9481 ccgtcaataa tgacagtgta tcacagattc tctccttttt ctttcattat cttttgaaaa
     9541 tcccataaat ttttatatta ttttgacttt ttccctataa caattccata aaatccaaaa
     9601 agtaataccc ccatccgatt ccaaatattt cccgcaaaaa aagatgtgta ccataccatt
     9661 tctgacacca tacacatctc aaaataaaca cttcttatct tctgtactcc gcagtcaggt
     9721 ctttaataac ctctcctgca ataatcagcc cggcgacaga cggcacaaag gccacactcc
     9781 ccggaatatc tctgcgctcc gtacacttat gcgcagcacc cggaggacaa atacaatgcg
     9841 acctgcagct gatcgccata tcttcaattg gtctgatcgg ctgttcctct gaataaacaa
     9901 ccttcagttt cttcacacca cgcttcttca gctctctacg cataaccttc gccagcggac
     9961 acaccttcgt cttatagata tccgccaccc gaaacgcact ggcatccagc ttatttccgg
    10021 cacccatact gctgataaca ggagtccctg cctcctttgc acgcatgatc agttcaatct
    10081 tcgcagtcac tgtgtccaca gcatctacca cataatcata ctcactaaaa tcgaaatcag
    10141 cagcattctc cggaagataa aaacagttat ggattctcac atctgctttc ggattaatgt
    10201 ccaggatcct gtcccgcatc acctctgttt tatattgacc aacagttttc ctggtggcaa
    10261 taatctgtct gttaagattc gtcaggcata ctttgtcatc atcgatcaga tcaaaggtcc
    10321 ccacaccgct tctgaccaat gcttcacata catatcctcc aacccctccg attccaaaca
    10381 ctgccacacg ggagttctcc agtttattca ttgcttcttt tcccagaaga agctctgttc
    10441 ttgaaaattg attcaacata atatctccat ttcattcggt attgaccgac tatctgcctg
    10501 cctttcttct acttcattat ttctggtctg ttctgctttg ctgcctgtaa tgtaagcagc
    10561 tctgcatgcc agaaacaaaa aaacaaggag cagaaaccaa agccagagct ttcttttgtt
    10621 ttttatgagc aaccgtttca taatctgcat cactattcct taatatatta ttttcagata
    10681 ccagagttgc aacatacttc catcacagat ttcttatgat atctttactt ctataatgcg
    10741 tcaagtatat catagaaaga aaaatcctgc aatgaagaaa ctctgttact gtacatgaag
    10801 tgaacagtgc tgagtgaaat tcacaaaccg gaagtgctta tccatctcat caccaatcaa
    10861 tccaattact tttcccatgg taaatgccgc catcactgtt ccgattccca gtccgttgat
    10921 atgccccagg atcagccctg tcatacaggc agtaatcatc agacagatca catcaaaaga
    10981 aaccttgatc ttagaatatt tcacctttat aatctctgac agttcacgag gaaacagatc
    11041 tgtaggaata atcggcagac cgcatctgtt agaaagtgcg atccctatac agatcagcag
    11101 ataactgatc acaaaatata acactctgag tggaattgtc tttggcagga tattgatcca
    11161 tgcctcatta acatccaaaa gctcactgaa tgcaaatcca accagaaaac tgcacagata
    11221 agcaggtaca aatttttttc tcagtatcat cagacttaag atcagaagtg cctgaaaaat
    11281 ataagtccat gttcccagtg taattaccgg aaatactttt tcaaatgcat aaggaacact
    11341 ggatatggca gatattcctg aaccagaata cagcatcaga ataacagcaa gactgttgat
    11401 catgactgct atcaccaatg ccagctctcc tctgaaaata tgtctcgaat cttcttcctc
    11461 atttgttttc ataacaattc tctcctctaa cacaagcaag ggactgctgt cagaaaatat
    11521 tttctgtcat acttttctga cggcagaccc ctgtgtcttt tacatcttat attttctgaa
    11581 aatactattt tttatcgaat caggcaagtt tcccacttca actactgata ttttcctgac
    11641 ttactcaacc gtgcagacgc ggatcaggtt tgttcttccc ggaattccaa gcggtacacc
    11701 accggcaaat acaatagtgt cgccaacttt tacaagttta tgcttctgtg ctgcttcgat
    11761 tgctctcagg caaaggatct cagaactgta ttcttctttg atcagcatcg ggtaaacacc
    11821 ccaggacaga ttcagctggc gaagaactct ctcagagctt gtacatgcac cgatcagaca
    11881 tcctggtctg tgtttggaca tcatatgagc tgtacttccg gattttgtca ctgcaaggat
    11941 tgcactggcc ttcaagtcga ttgctgtcag gcaggttgca tgtgcgattg catttgtaat
    12001 atccggattc tcatttctgt ctgttttctt aaagattgta ttgtaatcaa tattctgttc
    12061 catatgttct gcaatacggc tcatcatctg aagtgcctgt accggatatt taccagctgc
    12121 ggtttctcct gaaagcatag ttgcacttgt tccctgaaaa atcgcattgg caacgtctgt
    12181 agcctctgca cgggttggtc tcggatgaga gatcatggag tcaagcatct gtgttgctgt
    12241 aataaccggt tttcctgctg tgtaaacttt ctggatgatt ttctgctgga taacaggtac
    12301 atattccggc gggatctcaa cacccatgtc acctctggcg atcatgatgc catctgctgc
    12361 ttcaataatc tcgtcgatat tgtcaacgcc ctgctggttc tcaatctttg caatgatctg
    12421 aatctcttca ccgccgtttt ctttcaggat ttttcttact tcgcggatat cgtttgcagt
    12481 acgtgtaaaa gatgctgcaa cgaaatcaaa tccttcctgg ataccgaaga gaagatcatc
    12541 atggtctttt ttactgatga atggcatctt caggtttgca cccggaacat tgacaccctt
    12601 cttgtcgcca atcacacctg cattaataac cttgcagaca atgtcctttc ctgagatgtc
    12661 ctgaacctcc aggtctacaa gtccatcatc aaccagaata tgtccgcccg gccgcacatc
    12721 cttataaagc tctttataag taatgcttac gcactcatta gttccttcaa tatctttatt
    12781 tgtaaatgta aatatctgtc cttcttccag agaaaccttg ccatccttga agcatccaag
    12841 tctgatctcc ggtccctttg tatcaagaag tgctgcaaca ggtctgtcat atttcttgcg
    12901 aagttctctc agtttctgga tacggcctct ctgctcatcg tgaggtccat gtgagaagtt
    12961 gaaacgtgct acgtccattc cctctctcac aagctgctcc ataacatcgc ccttatcagt
    13021 agacggtccc attgtacaga taattttggt ttttctcatt taatctttcc ctccaaactg
    13081 tcaactcaat tttatctatt ttattcctgt aaaataatgt aataaaatgt tacctgtttc
    13141 tataaatgaa aacattaaat caaataaaaa ttaccattat tgagactatc tgtcaatata
    13201 gaatttcgac ttatttttgt tgatatttga caaaaaaata acatactttt gttgcaaata
    13261 tcacatatat ttttactgat ccgacagttg gaaaattttt cactcattct tatcagaatc
    13321 caaaatctgc atagtcttcc ggcagaaatc tgtggtaaat gatatggcat ccttcatctt
    13381 taaaacaata ataataagga tctgatccgt catcaaagcg gatcatcaca tcaaactcct
    13441 cgttatccat tggttcagta atgattttat ctgaataaga atggaacagt tctttaattt
    13501 cctctatcgt acatccatgt ctgccaacca gttcgatcaa tgccttgata aattcattct
    13561 ctttcatatt attatgtaca tattcggaag ctttttccga aacagtgaag cagaaacgat
    13621 ctcctctgtg tgatactgct acttcaccaa atttctcttc tatataagaa ggaaaatctt
    13681 ttaaaatctc catcatgcct gcagcatctg tctcaccgcc aaagaaatga ttcagggaac
    13741 tgagcggata ataaaggctg atcttctctt tcatatatcc aagcttcgcc tgttcctctt
    13801 tgatcacatc gatcagactg gtttctaatc tgttatagtt catttatttt ccctcctgaa
    13861 aatctgttct tttgcttttt ctggttaata ttttatcaga cattgcctga aaatcaatgc
    13921 atttcttttt caattgtacg cctgtcaaaa caatttcaat gttttctttt tcatacaaaa
    13981 ataaagacct tgcgaaactg tccttttttt ctccctctga caaatcactc tggctgaatg
    14041 aaacaaagca gacaaaacca tccccttcgt tgctttttta accaaataac tgcttgattc
    14101 ggttaaaaaa acagcgttcc aaatattatt tatatccgaa acgctgtcat tattccaatt
    14161 atttcattat gtatttaatc ccagttctta cgtccgtaac gaagtgtcac atcatatatt
    14221 tccttctgga gtttctttgt aagatctctc ttcttgattc tccacttcca gttcgtacca
    14281 actgtagatg gtttattcat tcggaatctg ttgtccagtc ccatatagtc ctgcattggg
    14341 ataacgcaga cacgcgcagc actgcgcatg atcagactga tgaaacactt atacagttct
    14401 tcttccggtg ttgcatgatc acacagataa tctctcgcca gttttctctc agctgctgtg
    14461 atgctcttcc accatcccac gatagtttca ttatcatggg ttcctgtata cgccacgcag
    14521 ttctccggat agttatgtgg cagataatca ctggcacatc cggaatctct ggagtcaaac
    14581 gcaaattcca gaaccttcat tcccgggaat ccgctctcat ataccagatg acgtacggaa
    14641 tctgtcatat atcccaagtc ctctgcgata acctgcttcc atccaagcgc ctgttcaatc
    14701 ttacggaaca gatcaattcc gggacccttt tcccagtgtc cgcctcttgc atctttatct
    14761 ccgtatggaa tagagaaata ttcatcaaat ccacggaaat gatcgattcg cacaacatca
    14821 tacagtctga agcagtaact cattctggaa atccaccact gatatcctgt atttctgtga
    14881 taatcccagc gatacagcgg atttccccat aactgaccgg ttgcagaaaa tccatccgga
    14941 gggcatcctg ctactgccag cggtacattg tcctgatcca gctggaacaa ctccggatgt
    15001 gcccatgcat cagcactgtc catggcaaca taaatcggaa tatctccaat gatctggatt
    15061 ccttttgaat ttgcatagga tttcagtttc atccactgct cataaaactt aaactgcata
    15121 tactgctgga attcaatatc aaaatagagt tcttcacgat aataatccat ggcattgttc
    15181 cagcggagtc tgatatcctc agcccatttg gtccattcta caccttcgaa acggtctttt
    15241 actgccataa acagagcata atctgacagc caccagctgt tctctgctac gaatttctga
    15301 tagtcaggat tcttgctgat atcactgttc tcgtatgctt ttctcagaag aggataacgg
    15361 cctttgtaga ttttttcata atctacctca tcaggcttct ttccccaatt aactttctcg
    15421 cagtctttct tatcaagaac tccttcttcc acaagtgtat ccagatcaat aaaatatgga
    15481 ttacctgcaa atgtagagaa agactgatat ggagaatctc catagctggt cggtcccaat
    15541 ggcagaatct gccagtaagt ctgtccggct tcctttaacc agtctacaaa ttcatatgca
    15601 cttttggaaa aacatccgat gccatagtct gatggaaggc tgctgatcgg cattaatatt
    15661 cctgctgctc tttttcccat gattcttatc tccttcgtga tttttcactt ttaccgctta
    15721 tatttctcca attgatccaa aatctggtat caacgttgct ataagcagca ttttatatac
    15781 cttat
//
