LOCUS       c00094_gnlPro..        15604 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HGONDGJO_94.
ACCESSION   c00094_gnlPro..
VERSION     c00094_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 06:09:15
            Original ID  :: gnl|Prokka|HGONDGJO_94
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 10007
            Orig. end    :: 25611
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15604
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[20007:25388]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..15381
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15604
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15604
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             1017..1352
                     /locus_tag="ctg94_9"
                     /transl_table=11
                     /translation="MPGADRASRHPLHFVQNHQNGFSLLMPLHFTFGYGNLDSRKGQRR
                     TIGNAQKTILKQHPISTFQNSMEFPYIFHLSAFRVKGIPILFGAVLYSHSYNCFSDRDA
                     PAGTERL"
     CDS             1356..2672
                     /locus_tag="ctg94_10"
                     /transl_table=11
                     /translation="MNKKGMIFEGLKVRNEIKKALQQEEGLPNCIQEENGYLSAEPGEH
                     AGKNVLKGERELKRVLEKLLEEDGQEICLDVTYFLVFAAAQNPVCREELKRLAPEQIIG
                     YQQMFLDNGYHGDYFLSCLGYEEHYFAQVLIGMLEKIREGSEERAEEAYHQFMGCIRKG
                     WRSARRELFTEETLDFERIQEWAGPYTEQPAMGMSQICMICLLAETCHVEIKKNVNFYL
                     ILECMIDRNTIWDSKKEEILEYEVWGRAGCADSCFYRRLEETVRNPFQAALGFRVEGYE
                     EFDCYLQNLFHLGGIDRNVLCGEELDERSRRLLLELGEFEKNSGMEKYVYSLYIVLLSG
                     YVKKCLDKIRENDPVRWQQKLDEQEREKEELKKQLTESEERFRSMKRKNSELEEKLELA
                     ERTVRRKENQLLRAAKQHQSEKQELVRLRESLYNSGRAG"
     CDS             complement(2913..3575)
                     /locus_tag="ctg94_11"
                     /transl_table=11
                     /translation="MVIGDDFVKKHNIVIGKCALFYMEHRFRVTDHRICKIPYKAAGKR
                     RHAGKSGRLVVFHDLSQYIQGLFCLHNLSLSLFFYIYFTVPAGHPHDRVISQKRISSPC
                     LSALYTLQKIISLRKPCELAQQSDWCCNIRIDFPAYRDNGIFLRQFQNCVAVRCDRHVF
                     PPFPKSGNKKAPAPSDFSNGTRAVNSKLLRYHPYCSYPLRNMNRSFMYYHTLLFDNG"
     CDS             3606..4559
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_12"
                     /sec_met_domain="Chorismate_bind (E-value: 1.5e-97,
                     bitscore: 316.7, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTDKVMENYGEATAEIARIAGLIKSAPVPAAEAEPEQIDFTCNV
                     SREEYCSIVEKTKEYIRDGDIFQAVISRQFCSPMRGSLLDAYRVLRTTNPSPYMVYLHF
                     DEEELMSTSPETLVRLQDGRLTAFPVAGSRPRGADAEEDEALEKDLLQDEKELSEHNML
                     VDLGRNDLGRISQFGSVEVTKYMMIHRYSKIMHICSQVEGTIRDDKDALDAVEAVLPAG
                     TLSGAPKIRACEIIEELESMERGVYGGAIGYLDFAGNLDTCIAIRMAVKKDGKVYVQAG
                     GGIVADSVPELEYEESANKAAAVMQAIKNAGEVEEL"
     CDS             4556..6160
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_trans_3N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_13"
                     /sec_met_domain="GATase (E-value: 5.9e-50, bitscore: 160.2,
                     seeds: 97, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_trans_3N (E-value: 2.2e-22,
                     bitscore: 69.4, seeds: 1422, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_3 (E-value: 1.4e-98,
                     bitscore: 320.1, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILLIDNYDSFTYNLVQMIGTINPDIRVIRNDEMTVEEIEALHPS
                     HIILSPGPGYPKDAGICEAVIKRLQGRVPILGVCLGHQAVCEVYGARISHARHLMHGKR
                     SRVFLQTESPIFAGMEEEIDAARYHSLIAEEGTIPQCLQVLSTDVENGEIMAVGHREYP
                     VYGLQFHPESILTPQGKNILENFLNIKAVRGDKIMIKEAIHTLMDGKDLNYEMAKAVMH
                     EMMDGIATQAQMGAFLAALRMQGESIDEITAFAEVMREKGIKIKPEREVIDIVGTGGDE
                     AGTFNISTTAAFVVAAGGVPVAKHGNRSVSSKSGAADVLENLGANVALDAKQNENILNK
                     TGMCFMFAPVYHSSMKYAAPVRKEMGVRTVFNILGPLSNPAAATMQLLGVYDKNLVEPL
                     AKVLGNLGVTRGVAVCGEDGLDEITLTGETTVCEIRFGETSCYTISPEQFGMKRCELSE
                     LVGGSPADNAQITRDILFGRETGPKRDVVLLNAGMSLYLGIDGITLQEGIDMARNLIES
                     GKAQAKFDEFVKATREQ"
     CDS             6177..6974
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IGPS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_14"
                     /sec_met_domain="IGPS (E-value: 5.5e-88, bitscore: 284.9,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILEQIARDTEIRVTQQKKKVPLGTLKKAAYQMETDTGFPFEKAL
                     AKEGLSFICEVKKASPSKGIIAEDFPYLDIAKEYEAAGADAVSCLTEPKYFLGADSYLK
                     EIAENVKIPVLRKDFVVEEYQIYEAKALGASAVLLICALIEPVLLKRYIQVCDTLGLSA
                     LVEAHDEKEISHAVWAGARVIGVNNRNLKDFSVDVGNSTRLRALAPKEILFVAESGIKG
                     PEDIARLKENEVNAVLIGETLMKSRDKKKMLSYLKGEDTSNEQ"
     CDS             6964..7599
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PRAI"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_15"
                     /sec_met_domain="PRAI (E-value: 5.8e-47, bitscore: 150.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSKVKICGLRRPEDIETANLYRPDFIGFVFANSSRRITEEQAEC
                     LRAGLADGILAAGVFVNAPVREAARIAEKGIIDIIQLHGDEDEAYIRSLKTFTKKPVIK
                     AVRVQSREQILEAEKLPCEYLLLDTYTKGQYGGSGKGFDLSLIPRLARPFFLAGGLSAE
                     NVQSALERSGAFAADVSSAVETEGYKDRDKVREFIRAVREQDSDTKNH"
     CDS             7622..8806
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_16"
                     /sec_met_domain="PALP (E-value: 2.5e-51, bitscore: 165.3,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKGRFGNYGGQYIPETLMNAVQELEEAYEKYSRDPEFNRELDHL
                     LKNYAGRPSLLYYAEKMTKDLGGAKIYLKREDLNHTGSHKINNVLGQVLLAKKMGKTRV
                     IAETGAGQHGVATATAAALMGMECEVFMGREDTDRQALNVYRMELLGAKVHPVDSGTAT
                     LKDAVNETMREWTRRMDDTLYVLGSVMGPHPFPMIVRDFQKIIGKEIKEQLQEREGRLP
                     DAVIACVGGGSNAMGAFYEFIKDEQVQLIGCEAAGLGVDTEKHAATIAKGTEGVFHGMK
                     SLFCQDEYGQIAPVYSISAGLDYPGIGPEHANLNKTGRAKYVPITDAEAVEAFEYLSKT
                     EGIIPAIESAHAVAYARKLAPTMDKDKIIVVNISGRGDKDVAAIARYRGVEIYE"
     CDS             8799..9581
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_syntA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg94_17"
                     /sec_met_domain="Trp_syntA (E-value: 8.1e-97, bitscore:
                     313.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKIYQAFENKKAFIPFITGGDPTLDVTEQLLYAIEEAGADLIEI
                     GIPFSDPTAEGPVIQEANERALKAGCTTDKLFDMIKRARQKVTVPIVFLTYVNPIFTYG
                     KERFMKKCVECGVDGIIVPDMPYEEKQELAPACDAYGIDIIPLIAPTSNARITMIAKEA
                     KGYIYCVSSLGVTGVRSEIKTDIGAMVELVRRATDVPCAVGFGISTPEQAYAMAKVSDG
                     AIVGSAIVKIVAKYGKDCVPYVAEYVKEMKAAVDRANN"
     CDS             10001..11437
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_18"
                     /sec_met_domain="CT_Vparvula (E-value: 6.8e-137, bitscore:
                     447.6, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTAQSLASKRIASLLDENSFVEIGGCVTARNTDFNLSEKETPA
                     DGVITGYGVIDGSLVYVYSQDASVLNGTIGEMHAKKIVRLYNLAMKTGAPVIGLVDCAG
                     LRLQEATDALNAFGEIYTKQVMASGVIPQITGIFGTCGGGLAIVPALTDFTFMEEKSGK
                     LFVNSPNALEGNEISKCDTSSAKYQSEEAGLVDVLGSEDEILAQMRQLVSMLPSNYEDN
                     SSYEDCADDLNRVCPELENCVGDTAIALSQIADNNEFFEVKAAYAKDMVTGFIRLNGAV
                     VGCVANRSEVYNDEGEKTESFDNVLSARGCKKAADFVKFCDAFEIPVLSLTNVKGYKAT
                     KCSEANIAKAAAQLTYAFTNATVPKVNIVIGEAFGSAYLAMNSKSTGADMVFAWPGVQI
                     GMMDARLAAKIMYADSDAATINEKAAEYADLQSSALSAAKRGYVDSIIEAEDTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             11452..12219
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_19"
                     /sec_met_domain="OAD_gamma (E-value: 2.6e-25, bitscore:
                     79.6, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQTWKKLIGLILIGVCALAMTACGSSKDSTGGLKKLDDATVDSL
                     VESFGGVVGNIADLDEESIAGLMEGDDAFSASAAVAWDGAGEDLGAYVETSKGKVEIKD
                     GSYILTLACKFENRDADCVFTLDKNGNPLSVSIDPKYSMGEKMAQAGQNTILGIGTVFV
                     MLVFLCFVISLMKYIPGFVASFDKKKTAPEEIQVPAAPAAKAIPEAAEEEVVDDGELIA
                     VIAAAIAASENTSTDSFVVRSIRKSTKRNWQRA"
     CDS             12238..12609
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.3; E-value:
                     2e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_20"
                     /sec_met_domain="Biotin_lipoyl (E-value: 7.2e-20, bitscore:
                     61.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGVAYDVTVEEGAGNAAAPAAAPKAAPKAAPKAAPAA
                     KPAASAAGVVAVTASVPGKVFKVEANVGQAVKAGDNIIILEAMKMEIPVVAPQDGTIAS
                     IDVAVGDSVENGDTLASMN"
     CDS             12726..13883
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_21"
                     /sec_met_domain="OAD_beta (E-value: 1.1e-157, bitscore:
                     515.0, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVTDTLSNLLHQTAFFNLTWGNYLMILVAFGFLFLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMALPYTDAAGIEHAGGLLHYFYLLDEWSILPSLIFMGVGA
                     MTDFGPLIANPKSFLLGAAAQLGIYMAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLA
                     GKLGQTVLMGPIAVAAYSYMSLVPIIQPPIMKLLTTEKERKIKMEQLRPVSKLEKILFP
                     IIITVVVCLILPTTAPLVGMLMLGNLFRESGVVKQLSETASNALMYIVVILLGTSVGAS
                     TSAEAFLKLDTLKIVVLGLVAFAVGTAGGVLLGKLMCKLSGGKINPLIGSAGVSAVPMA
                     ARVSQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             13969..15381
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg94_22"
                     /sec_met_domain="HMGL-like (E-value: 7.5e-45, bitscore:
                     144.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 2.6e-58, bitscore:
                     187.6, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEVVKKPIKITETILRDAHQSLIATRMSTEQMLPIVDKLDKVGY
                     HSVECWGGATFDASLRFLKEDPWERLRKFRDGFKNTKLQMLFRGQNILGYRPYGDDVVE
                     YFVQKSIANGIDIIRIFDCLNDLRNLQTAVKASNKEKGHAQVALSYTLGDAYTMDYWVD
                     MAKRVEDMGANSICIKDMAGLLVPYEATNLVTALKAAVDIPIQLHTHYTSGVASMTYLK
                     AVEAGVDVIDTAMSPFALGTSQPATEVMVETFKGTPYDTGFDQNLLAEIADYFRPIRDE
                     ALESGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYEVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVIMGERYKMVTKETKDVLSGKYGATVKPFDPEVQKKCIGD
                     TEPITCRPADLIPDELDTLRNEMAQWSEQEEDVLSYALFPQVATEFFKYREAQETKVDP
                     KAADTENGAYPV"
     CDS             complement(15378..15602)
                     /locus_tag="ctg94_23"
                     /transl_table=11
                     /translation="VERPEIHLPQLLNEEANADEFSNWEQVSSTAAERFVPRPPASPAL
                     SSPLPSPLIKKRRPKAPFLTAPSPFYAKH"
ORIGIN
        1 catgatcgga gatccttcag ggagaacgga tatgcgccag atgatgacag aggagaccat
       61 tcagtataac tgtgactgtt tcagaaaaca gatgagccgt tttattgact tctctgaggg
      121 caaagccctt atggtaaata atgcggactg gcttctggat ctcaactatg tggagatgtt
      181 aagggaggtt ggcgcccatt tttctgtaaa caatatgctg cgcgcagagt gttacaaaca
      241 gcgtatggaa aaaggactga gtttctttga atttaattac atgatcatgc agagctatga
      301 cttttacatg ctgtacaaga attacggctg taatatgcag ttcggcggag acgaccagtg
      361 gagcaatatg ctgggcggaa cagagctgat ccgccgtaag ctgggaaaag atgcgtatgc
      421 catgaccatc actctgcttc tgaattcaga gggcaagaag atgggcaaaa ctcagtcagg
      481 cgctgtctgg ctggatccca ataagacaac accttttgac ttctatcagt attggagaaa
      541 tgtcagcgac gcagatgtgc tgaaatgtct tcgcatgctt accttcctgc ctttggagca
      601 gattgatgag atggataaat gggagggcag ccagctcaac acagcaaaag agatcctggc
      661 ttacgaactg actgatctgg tacatggcga ggaagaggct aaaaagtccc aggaagcagc
      721 aagggcttta tttaccagcg gtaatgcagc ggatatgcca tcagctttca tcgagcagtc
      781 agacttacag gaaggaaata ttgacctcat cacacttctg cacaagagcg gtttggtagg
      841 cagccgttcc gagggaagaa gagccattga gcagggcggt gtggcaattg acggtgagaa
      901 gatcacagat gtcaaatatg tgatcccggg agaaaagttg gactgagacg ggatcgtgct
      961 gaaacgcggt aagaaaaact tccgtaaagt gacaataaaa taatataata caagagatgc
     1021 cgggggctga cagagcttcc cggcatccgt tacattttgt gcaaaatcat caaaatggat
     1081 tttctctgtt aatgccattg cattttactt ttggatatgg taatctggat tcacgaaaag
     1141 gtcagcgccg tacgatcgga aacgcgcaga aaacaattct aaagcaacac cctatatcca
     1201 catttcaaaa ttctatggaa ttcccgtata ttttccattt atcagcattt agagtcaaag
     1261 gaataccaat attgtttgga gctgtactat attctcacag ttacaattgt ttttctgatc
     1321 gtgacgcgcc tgccggaaca gagaggttat gaggaatgaa caaaaaagga atgatatttg
     1381 aagggctgaa agtgcgcaat gagatcaaaa aagcactgca gcaggaggaa ggactgccca
     1441 attgtattca ggaggagaac ggatatctgt cagcagaacc gggagagcat gcaggaaaaa
     1501 atgtactcaa aggcgagaga gagctgaaac gtgtattgga aaagctgctg gaggaggatg
     1561 gacaggagat ctgtctggat gtaacttatt ttctcgtttt tgcagcagcg cagaatcccg
     1621 tctgcagaga agagttaaaa agactggcac cggagcagat cattggatat cagcagatgt
     1681 ttttggataa cgggtatcac ggtgattact ttttgtcctg tctgggctat gaggaacatt
     1741 attttgcaca ggtgctcatt ggtatgcttg aaaagatacg ggagggcagc gaagagaggg
     1801 cggaggaagc ttatcatcag tttatgggct gcatccgcaa aggatggcgc agtgccagac
     1861 gggagctttt tacagaagag actctggact ttgaacggat acaggagtgg gccgggcctt
     1921 acacagaaca gccggccatg ggtatgagcc agatctgtat gatctgcctg ctggctgaga
     1981 cctgtcatgt agagattaaa aagaatgtaa atttctatct cattctggag tgtatgattg
     2041 acagaaatac gatctgggac agtaaaaaag aggaaatttt agaatacgag gtctggggaa
     2101 gagcgggctg cgcggacagt tgtttttacc ggagactgga agaaacagtg aggaatccgt
     2161 tccaggcagc cttgggattt agggtggagg gatatgaaga gtttgactgt tatctgcaaa
     2221 atcttttcca tctggggggc atagacagga atgtgctgtg cggagaagaa ctggacgaga
     2281 gatcacggcg gcttttactg gaactgggtg agtttgagaa aaattcgggt atggagaagt
     2341 atgtctattc tctttatatt gttttactgt ccggatatgt gaaaaaatgt ctggataaga
     2401 tccgggaaaa tgatccggtc agatggcagc agaaattaga tgagcaggaa agagaaaagg
     2461 aggaattaaa aaagcagctt acagaatcgg aggagcgttt ccgcagtatg aaaaggaaaa
     2521 acagtgagct ggaagaaaaa ctggagctgg cagaacggac tgtgcgccgc aaagagaacc
     2581 agctcctgcg cgcggccaag cagcaccagt ccgaaaaaca ggaacttgtc aggctgagag
     2641 aaagtctata taattcaggt agagccggat gatgccatgc ttggccgaag aaaatttcaa
     2701 atcatctatt gacaaatacc ccatacggca ttataattga aaaaaagttg aattgattaa
     2761 cactttaaac cgatgaacaa gaagagtaag taaaaatatt tattcccaga gagccgttgt
     2821 tggtggaaat acggcagtaa gagtttttac cgaatggcct tgtgagggca gcttgaaacc
     2881 ttcctggagg ggagtagacg ctgacgggga gcttatccgt tatcaaagag cagtgtatga
     2941 tagtacatga aagagcggtt catattacgt aaaggatatg agcaatatgg gtggtaccgc
     3001 aggagtttag aatttacagc tcttgtccca ttggagaaat ctgatggggc aggagctttt
     3061 ttattgccgc tctttggaaa gggaggaaaa acatgacgat cacaccggac tgcaacacaa
     3121 ttttgaaact ggcggaggaa tattccattg tccctgtatg cagggaaatc tatgcggatg
     3181 ttacaacacc aatcactctg ctgcgcaagc tcacagggct ttctaagaga tattatcttc
     3241 tggagagtat agagggcgga gagacatggg gaagatattc ttttctggga tatgacccgg
     3301 tcatgcgggt gacctgcagg gacagtaaag tatatataga aaaacaggga aagactgaga
     3361 ttgtggagac agaaaagccc ctgaatgtat tgagagagat catgaaagac tacaagtctc
     3421 ccagactttc cggcatgcct ccgtttaccg gcggctttgt agggtatttt gcatattcta
     3481 tgatcggtta cgcggaaccg gtgctccata taaaaaaggg cacatttccc gattacgatg
     3541 ttatgctttt tgacaaagtc atcgcctatg accatctgaa gcagaagata tgtatcattg
     3601 tgaatatgcg gacggataag gtgatggaga attatggcga ggctacagcg gagatcgcaa
     3661 ggatcgccgg gctgatcaaa agcgcaccgg tgcctgcggc tgaagcggag ccagagcaga
     3721 ttgatttcac ctgtaatgtg agcagggagg aatactgcag cattgtagag aagacgaaag
     3781 aatatataag agatggggat atcttccagg ctgttatttc caggcagttt tgcagtccta
     3841 tgagaggaag ccttttagac gcttacagag ttcttcggac aacaaatcct tccccgtata
     3901 tggtttacct gcattttgat gaggaggaac tgatgagcac ttcaccggag actctggtcc
     3961 gccttcagga tggcaggctg actgccttcc cggtagcagg ctccaggcca aggggggcgg
     4021 acgcagagga ggatgaagct ttggaaaaag atcttctgca ggatgaaaag gaactgtcag
     4081 aacataatat gctggtagac ctggggagaa atgatctggg acgcatcagt cagtttggtt
     4141 ctgtggaagt gacgaaatat atgatgatcc accgttattc taagatcatg cacatctgtt
     4201 cccaggtgga gggaaccatc cgggacgaca aggatgcatt ggatgcagtt gaagctgtac
     4261 ttcctgcggg aactctttcc ggcgcgccca agatcagggc atgcgagatc atcgaggagc
     4321 tggagagtat ggagagaggt gtctacggag gtgccatcgg ctatctggat tttgccggca
     4381 atttggatac ctgtattgct atccgcatgg cagtcaaaaa agacggtaaa gtctacgtac
     4441 aggcaggcgg cggaattgtg gcagacagtg ttccggagct ggaatacgaa gaatcggcaa
     4501 ataaagcggc agcagtgatg caggccatta aaaatgccgg ggaggtggaa gagttatgat
     4561 attgttgatt gataattacg acagttttac atacaacctg gtacagatga taggcaccat
     4621 taacccggac atccgggtga taagaaatga tgagatgaca gtggaggaga tagaggcatt
     4681 acatccttcc cacattatcc tgtcaccggg accgggatat ccgaaggacg ctggaatctg
     4741 tgaagcggtt attaagagac tgcagggcag ggtgcctatc ctgggtgtct gcctgggaca
     4801 tcaggctgtc tgtgaagtgt acggcgccag gatcagccac gccagacatt tgatgcacgg
     4861 aaaaagaagc cgggtatttc ttcagacaga gagtcccatc ttcgcaggca tggaggaaga
     4921 aatagacgcg gccagatacc actcccttat agcggaggag ggaaccattc cccaatgtct
     4981 ccaggtcttg tccacggatg tggaaaatgg ggaaatcatg gcagtagggc acagagagta
     5041 tccggtatat ggacttcagt ttcatccgga atccattctc acaccccagg gaaagaatat
     5101 acttgaaaat tttttaaata taaaagctgt aagaggagat aagatcatga tcaaagaggc
     5161 aattcataca ctgatggacg gcaaggattt aaactatgag atggcaaagg cagtcatgca
     5221 tgaaatgatg gatggcattg ccacacaggc acagatggga gcttttctgg cggcgcttcg
     5281 catgcaggga gagagcatag atgagatcac agcctttgct gaggtcatga gggaaaaagg
     5341 gatcaagatc aaaccagaga gagaagtcat agatattgtg ggaacgggag gagacgaggc
     5401 aggaaccttt aacatttcca ccacagcggc gtttgtagtc gcagcgggcg gagtgcctgt
     5461 ggcaaaacac ggaaaccgca gcgtatccag taagagcggt gcggcagatg tcctggaaaa
     5521 tctgggtgcc aatgtggctc ttgacgcaaa acagaatgag aacattctca acaagacagg
     5581 gatgtgcttt atgtttgcgc cggtttatca ctcttctatg aaatacgcgg ctccggtgag
     5641 aaaagagatg ggggtgcgca ccgtgttcaa tatattaggc cccctctcca acccggcagc
     5701 agctaccatg cagcttcttg gcgtatacga caaaaatctg gtggaaccgc tggcaaaggt
     5761 gctgggcaac ttaggtgtga ccagaggagt cgctgtgtgc ggtgaggacg gcctggatga
     5821 gatcaccctg acaggggaga ccacagtctg cgaaatacgt tttggagaga cttcctgcta
     5881 caccatatca ccggagcagt ttggaatgaa acgctgtgaa ctttctgaac tggtgggcgg
     5941 ctctcctgct gataacgcac agatcaccag ggatattctc ttcgggcgtg agacaggacc
     6001 aaaacgcgat gtggtgcttt taaatgcggg tatgagtctc tatctgggga ttgacggcat
     6061 cacattgcag gagggcattg atatggcccg gaatctgata gagagcggaa aggcacaggc
     6121 aaaatttgat gaatttgtaa aagccacaag agaacagtaa aggaggagac tgaaaaatga
     6181 tactggaaca gatagcgaga gacacagaga tccgggtgac ccagcagaaa aagaaagtcc
     6241 ctctcggaac cctgaaaaaa gcggcatacc aaatggagac agatacagga ttcccctttg
     6301 aaaaagccct ggcaaaggag ggactcagct tcatatgtga ggtgaaaaaa gcctcccctt
     6361 caaaagggat catcgcagaa gattttccgt atctggatat cgcaaaggaa tacgaagcgg
     6421 cgggggcaga tgctgtctcc tgtctgactg agccgaaata ttttctggga gctgacagct
     6481 atctgaagga gatcgcggaa aatgtgaaga ttccggttct caggaaagat tttgtggtgg
     6541 aagagtatca gatatatgag gcaaaggctc tgggtgccag cgctgtgctg ctgatctgtg
     6601 cgctcatcga gccggtgctt ctgaaacgat acattcaggt gtgcgacact ttggggcttt
     6661 cggctttggt ggaagcccat gacgagaaag aaatttcaca tgccgtgtgg gcgggagcca
     6721 gagtcatcgg cgtgaataac cgcaatctga aggatttcag cgtggatgtg ggaaacagca
     6781 caaggcttcg cgctctggcg ccgaaagaga tcctgttcgt ggcagagagc ggtataaaag
     6841 gtcccgagga tattgcgcgc ttaaaggaaa atgaagtgaa tgctgtgctg atcggtgaga
     6901 cgctgatgaa gagcagggat aagaaaaaaa tgctttctta cctaaaagga gaggatacat
     6961 ccaatgagca gtaaagtaaa gatctgcggc cttaggcgtc ctgaggacat agagacagcc
     7021 aacctgtacc gtccggattt tatcgggttt gtctttgcga acagcagccg gcggatcacg
     7081 gaagaacagg cagagtgctt aagggcagga ctggcggatg ggatcctggc ggcaggcgta
     7141 tttgtaaacg ctccggtccg ggaggcagca aggatcgctg aaaaggggat catagatatc
     7201 attcagcttc acggagatga ggatgaagcc tatatccgca gtctgaaaac atttactaag
     7261 aaaccggtga taaaagcagt ccgcgtacag agccgggagc agatcctgga agcggagaag
     7321 ctgccctgcg agtatctgct acttgacacc tatacaaagg gacagtacgg aggaagcgga
     7381 aaaggatttg acctgtcgct cattccaagg cttgccagac cattttttct ggccggaggc
     7441 ctgagtgccg aaaatgtgca gagcgctctt gaaagaagcg gtgcatttgc agcagatgtc
     7501 agcagcgcag tggagacaga gggatataaa gacagggaca aggtcaggga atttatccgg
     7561 gcggtccggg aacaggattc ggacacgaaa aaccattgat tataaagaag aggatgaaaa
     7621 tatgagcaaa ggtagatttg gcaattacgg aggacagtac attccggaga cactgatgaa
     7681 cgcagtgcag gagctggagg aagcctatga gaaatacagc agggacccgg aatttaacag
     7741 ggagctggac catctgctga aaaattatgc gggccgccct tctctgctgt actatgccga
     7801 gaagatgaca aaggatctgg gaggcgcgaa gatatacctg aagagagagg atttgaacca
     7861 taccggttcc cataagatca acaatgttct gggacaggtg ctccttgcga agaagatggg
     7921 caagacgaga gttatcgctg agacgggagc gggacagcac ggtgtggcca cagctacggc
     7981 agcggccctt atggggatgg aatgtgaagt cttcatggga cgtgaggaca cagaccgcca
     8041 ggcactgaat gtataccgca tggaactgct gggggcaaag gttcaccctg tggacagcgg
     8101 aacagccact ttgaaggatg ctgtaaatga gactatgaga gagtggacca gaaggatgga
     8161 cgataccctt tatgtgttgg gttctgtcat gggtccccac cccttcccta tgatcgttcg
     8221 tgatttccag aagatcatcg gaaaggagat caaagaacag cttcaggaaa gagaaggcag
     8281 acttccggat gctgtgatcg cctgtgtggg cggcggcagc aacgccatgg gagcgtttta
     8341 tgaattcatc aaggatgagc aggtgcagct catcggatgt gaagcggcag ggcttggtgt
     8401 ggatacggaa aaacatgcgg caaccatcgc aaaaggaaca gagggagttt tccatggtat
     8461 gaaatccctg ttctgccagg atgagtacgg acagatcgct ccggtatact ccatttccgc
     8521 aggactggat tacccgggta tcgggccgga acatgccaat ctgaacaaga cgggaagggc
     8581 caaatatgtg ccgatcacag acgccgaagc ggtggaggca tttgaatatc tctccaagac
     8641 agagggaatc ataccggcta tcgaaagcgc ccacgcagtg gcatatgcca ggaaactggc
     8701 tccgaccatg gataaggata agatcatagt ggtaaatatt tccggcagag gcgacaagga
     8761 cgtggctgcc attgcacgat acagaggagt ggaaatttat gagtaaaata tatcaggcat
     8821 ttgaaaacaa aaaggcattt attccgttta tcacaggcgg tgaccctacg cttgatgtga
     8881 cagagcagct tttgtacgcc atagaggaag caggagctga tctgatagag atcggcatcc
     8941 ctttttctga ccctacagca gaaggaccgg tgatccagga ggcaaatgag agagccttaa
     9001 aagcgggatg caccactgac aaattgtttg acatgataaa aagggcgaga cagaaggtca
     9061 cagtgccgat cgtgtttctc acctatgtga atcctatttt tacatatggc aaggagcgct
     9121 tcatgaaaaa atgtgtggag tgcggcgtgg acggcatcat cgttccggat atgccctatg
     9181 aagaaaaaca ggagctggcg cctgcgtgtg atgcctatgg cattgacatc attcctctta
     9241 tagcacccac ttcaaatgcc cgcatcacca tgatcgcaaa ggaggcaaag ggatatatct
     9301 actgtgtctc ttctctggga gtgaccggtg tgagaagtga gatcaagacg gacatcggcg
     9361 ccatggtaga gctggtgcgc cgggccacag atgtgccctg cgccgtgggc ttcggcattt
     9421 ccacaccgga acaggcatac gccatggcaa aggtttcaga cggagccatt gtaggctctg
     9481 caattgttaa aattgtggca aaatatggaa aggactgtgt gccctatgtg gcggagtatg
     9541 taaaagaaat gaaagctgcc gtggaccggg caaacaactg agaacagcgg aggatggaaa
     9601 attccatcct ccttttttgc gtaaagcccc gcatttccag actcttcctg cgtaaccatg
     9661 cagatcagcg cggtaaatac acggatatgg gggattagat ctgtatggcg ccggctgctt
     9721 tggaattttg ccgggtatgg tgcagtatct ccccggggaa aacgccttgc gggataatgt
     9781 cccgtaaata gtaacaaaaa tattcataat aattaaatat ttcacaaatt tttgttgaaa
     9841 aatccctgga aacaaggtac aattaaaatc ggcagaaatt ggttttgtct tttaattcaa
     9901 caaagtaaaa ccaggaggcg atttctgcat gaaaaccgga ttatcacgca gatttttcgt
     9961 gcagaatcca ggtaaataat aaaaaatgga gggctgataa atgagtaata cagcacaaag
    10021 cttggcaagt aaaagaattg cttctttact tgatgagaac agttttgttg aaatcggcgg
    10081 ctgtgtcaca gccagaaaca cagatttcaa cttatctgaa aaggaaacac cggcagacgg
    10141 tgtcatcacc ggttatggtg tcatcgacgg cagcctggtg tatgtgtaca gccaggacgc
    10201 ttccgttctg aacggaacca ttggtgaaat gcatgccaaa aagattgtca gactttacaa
    10261 tctggcaatg aagacaggcg ctccggttat cggacttgtg gactgcgcag gcttaagact
    10321 gcaggaagcc acagatgcgc tgaacgcttt tggcgagatt tataccaaac aggttatggc
    10381 atcaggtgtg atcccgcaga tcacaggtat ttttggaacc tgcggcggcg gccttgcaat
    10441 tgttccggct cttaccgatt tcaccttcat ggaagagaag agcggtaaac tgtttgtaaa
    10501 ctcccccaac gctttagagg gaaatgaaat ttccaaatgt gatacttcca gtgcaaaata
    10561 ccagagtgaa gaggctggtc tggtagatgt tctgggaagc gaagatgaaa tcctggcgca
    10621 gatgagacag ctggtatcca tgctgccttc caactacgaa gataattctt cctacgaaga
    10681 ctgcgcagat gacttaaacc gtgtatgccc ggaactggaa aactgtgtgg gagataccgc
    10741 cattgcactt tcccagatcg cggacaacaa tgagttcttt gaagtaaaag ctgcatacgc
    10801 aaaagatatg gtgaccggat tcatccgtct gaacggcgct gttgtgggct gtgttgccaa
    10861 cagaagcgaa gtttacaacg atgaagggga gaagacagag tcctttgaca atgtgctctc
    10921 tgcaagagga tgtaaaaaag cagcggattt cgtgaaattc tgtgacgctt ttgaaatccc
    10981 ggttctgtcc ctgacaaatg taaaaggcta taaagcaaca aaatgctctg aagccaacat
    11041 tgccaaggca gccgcacagc ttacttacgc atttacaaat gcaaccgtac cgaaggtgaa
    11101 catcgtgatc ggtgaggcat tcggaagtgc atatctggca atgaacagca aatccacagg
    11161 agctgacatg gtattcgcat ggccgggagt tcagatcggt atgatggacg cacgtcttgc
    11221 tgcgaagatc atgtatgcag atagcgatgc tgcaacgatc aatgaaaaag ctgctgaata
    11281 tgctgactta cagtcaagcg ccctgtctgc tgccaagaga ggttatgtgg attccatcat
    11341 cgaggcagaa gatacaagaa aatatgtgat tggtgctttt gaaatgttat tcacaaagag
    11401 agaagatcgt ccaagcaaga aacacggcac ggtttaggtg aggtgaatca tatgaagcag
    11461 acatggaaaa aattaattgg tttaatcctg atcggagtat gcgcgctggc tatgacagcc
    11521 tgcggaagca gcaaagactc cacaggcggt ttaaaaaagc tggatgatgc aactgttgac
    11581 tctcttgtgg agagctttgg cggcgttgtc ggcaacattg ctgatctgga tgaggagtct
    11641 atcgcaggtc tgatggaagg cgatgacgca ttcagcgctt ccgctgccgt tgcgtgggac
    11701 ggtgccggcg aagatctggg cgcatatgtg gagacatcca aaggcaaagt ggagatcaaa
    11761 gacggcagct atatcctgac actggcatgt aagtttgaga accgcgacgc ggactgcgtc
    11821 tttacattag ataaaaacgg caatcctctc agtgtgagca ttgacccgaa atattcaatg
    11881 ggcgaaaaaa tggcacaggc aggacagaat acaattctgg gtataggaac tgtttttgtt
    11941 atgctggtat tcctgtgttt tgttatttcc ttaatgaaat acattccggg atttgtagcg
    12001 tcctttgaca agaagaaaac tgctccggaa gaaattcaag ttccggctgc tcctgctgct
    12061 aaagccatac cggaggcagc agaggaagag gttgtggatg acggcgagct gatagcagtc
    12121 attgcggcag ccatcgcagc atctgaaaat acatctacag acagttttgt agttcgttcc
    12181 atcagaaaat caacaaaaag aaattggcag agagcctaat cacaggagga aatggttatg
    12241 aaatcttata caattacagt taatggcgtt gcatatgatg taacagtaga agagggcgca
    12301 ggaaacgcag cagctcctgc ggcagcaccg aaagctgctc ctaaggcagc accaaaagcc
    12361 gctccggcag caaaacctgc agcatctgca gcaggcgtag tggcagttac cgcatctgtt
    12421 ccgggtaaag tgttcaaagt ggaagcaaat gttggacagg cagtaaaagc cggcgataac
    12481 atcatcatcc tggaagccat gaaaatggaa attccggttg ttgctccgca ggacggtacc
    12541 attgcaagta ttgatgtggc agttggtgat tccgtagaaa acggcgatac actggcatcc
    12601 atgaactaga atttacaaac atttgtaaat tcccgacagc taagagataa atcttgctga
    12661 tacaatagaa agcacaaatc gaaaactttc tattgtcacg aatacgaaca atgggaggta
    12721 atataatgtc taacgttaca gatacactgt ctaacctgct ccaccagaca gcgtttttca
    12781 atctgacatg gggaaattac cttatgattt tagttgcctt tggttttctt ttcctggcaa
    12841 ttaaaaaagg atttgaaccg cttcttctgg tgccgattgc cttcggtatg ctgttggtta
    12901 atatctatcc ggatattatg gcactgccat acacggacgc agcaggaatc gagcacgcag
    12961 gtggacttct tcactatttt tatctgctgg atgaatggag tattcttccg tccttgatct
    13021 tcatgggcgt aggtgccatg acggacttcg gtcctctgat cgccaatccc aagagctttc
    13081 ttttgggtgc tgcggcacag cttggtatct acatggcata cttcctggcg atctttttgg
    13141 gattcaatgg aaaagcagca gcagccatct ctatcatcgg cggtgctgac ggcccgactt
    13201 ccatcttcct ggcaggtaag cttggacaga cagtccttat gggacccatt gcggtggcgg
    13261 catattccta tatgtccctg gttcccatca tccagccgcc gatcatgaaa cttctcacta
    13321 cagagaaaga acgtaagatc aaaatggaac agcttcgccc ggtttccaaa ctggaaaaaa
    13381 tcctgttccc gatcatcatc accgttgttg tttgtctgat tcttcctaca acagctccgc
    13441 tggttggtat gctgatgctt ggtaacctgt tccgcgaatc aggtgttgta aaacagttaa
    13501 gcgagacagc atccaatgct cttatgtata ttgtagttat cttactggga acttccgtag
    13561 gtgcttctac aagcgcagag gcatttttga aactggatac cctgaagatc gtcgttttag
    13621 gtctggttgc atttgcagtc ggtacggcag gcggtgtgct tcttggtaaa ctgatgtgta
    13681 aactgtccgg cggtaagatc aatccgctga tcggttcagc cggagtatct gccgttccta
    13741 tggcagcccg tgtatcccag aaggttggtg ctgaggcaga cccgactaac ttcctgctga
    13801 tgcacgcaat gggcccgaat gttgcaggcg ttatcggtac tgcggtagca gcgggtacct
    13861 tcatggcaat cttcggtgtt taatatttaa gaaaatccat ataacgattc taaatttatt
    13921 taggattttc ttattgtcat gatttcaaaa ttttaggagg aaattaagat ggcagaggta
    13981 gtaaaaaaac ctattaagat tactgaaaca atcttacgtg atgcacatca gtccctgatt
    14041 gcgaccagaa tgtccacaga gcagatgctg ccgatcgtag ataaactgga taaagtcggt
    14101 tatcattccg tagagtgctg gggcggtgca acctttgatg catcccttcg tttcttaaaa
    14161 gaagatccat gggagagact gcgtaagttc cgtgacggat ttaagaatac gaaactgcag
    14221 atgctgttcc gtggtcagaa cattctggga taccgtcctt atggggatga cgtggtagag
    14281 tatttcgtac agaaatccat tgccaacggt attgacatta tccgtatttt tgactgtctg
    14341 aatgacttga gaaacctgca gacagcagta aaagcttcca acaaggaaaa aggacatgca
    14401 caggtggctc tgtcctacac cctgggcgat gcttacacta tggattactg ggtagacatg
    14461 gcaaaaagag tagaggatat gggtgcaaat tctatctgta tcaaggatat ggccggtctg
    14521 ttggttccgt atgaggcaac aaatctggta actgctctga aagctgctgt ggatattccg
    14581 atccagctcc acacacacta tacctcaggt gttgcttcca tgacttactt aaaagctgta
    14641 gaggcaggcg tagacgtgat cgatactgct atgtctcctt tcgctctggg aacatcccag
    14701 ccggctacag aggttatggt tgagacattc aagggaacac cttatgacac aggatttgac
    14761 cagaatcttc tggcagagat cgctgactat ttccgcccga tccgtgatga ggcgctggaa
    14821 agcggtctgc tgaatcctaa gaacctgggt gttaatatta agactctgct gtatcaggtg
    14881 ccgggcggta tgctctccaa cctgaccagc cagttaaagg aacagcacgc agaggacaag
    14941 ttctacgagg ttctggaaga agttccgaga gtgcgtaaag acctgggcga gccgcctctg
    15001 gtaactccgt cctcacagat cgttggtaca caggctgtat tcaacgtgat catgggcgag
    15061 cgctacaaaa tggttacaaa agagacaaaa gacgttctca gcggaaaata cggtgctacg
    15121 gttaaaccgt ttgatcctga agtacagaag aagtgtatcg gtgatacaga gccgatcacc
    15181 tgccgtccgg ctgatctgat cccggatgaa ctggatactt taagaaatga aatggcacag
    15241 tggtccgaac aggaagagga cgtattgtct tatgcgttat tcccgcaggt ggcaaccgag
    15301 ttctttaagt atagagaagc acaggagact aaggtggatc ctaaggctgc ggatacggag
    15361 aatggggctt atcctgttta atgtttagca tagaagggcg agggtgccgt gaggaacggt
    15421 gcctttggcc ttcttttttt tattaagggg gacggaagcg gagatgagag ggccggggac
    15481 gcaggaggcc ggggaacgaa gcgttccgct gccgtggagc taacctgctc ccagttacta
    15541 aattcatcgg cattggcctc ttcattaagt aactggggca ggtggatctc cgggcgctcc
    15601 acta
//
