## Mon Jul 1 20:41:44 2024 ## emapper-2.1.12 ## /d223NFS/m128030022/anaconda3/envs/eggnog/bin/emapper.py -i /d223NFS/m128030014/NGP/gene_list/prokka_results/GCA_020697615.1/GCA_020697615.1.faa --temp_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_020697615.1/2.eggNOGmapper --output_dir /d223NFS/m128030022/NGPs/NGPs_new/databases/NGPs_DB/NGPs_db/GCA_020697615.1/2.eggNOGmapper --output eggNOG_out --override --cpu 20 -m diamond --sensmode fast ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs KKPNOBBG_00001 33035.JPJF01000002_gene2506 0.0 926.0 COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3XYZ0@572511|Blautia 186801|Clostridia M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M KKPNOBBG_00002 33035.JPJF01000002_gene2505 0.0 1385.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3XYQI@572511|Blautia 186801|Clostridia L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII KKPNOBBG_00003 33035.JPJF01000002_gene2504 2.89e-105 304.0 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,3Y03J@572511|Blautia 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase KKPNOBBG_00004 33035.JPJF01000002_gene2503 5.97e-196 546.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,3XYI1@572511|Blautia 186801|Clostridia J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N KKPNOBBG_00005 33035.JPJF01000002_gene2502 0.0 868.0 COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,3XZPF@572511|Blautia 186801|Clostridia J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB KKPNOBBG_00006 33035.JPJF01000002_gene2501 1.35e-238 657.0 COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,3XZJW@572511|Blautia 186801|Clostridia J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM KKPNOBBG_00007 33035.JPJF01000002_gene2500 3e-169 473.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,3XYRV@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 8.87 stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 KKPNOBBG_00008 33035.JPJF01000002_gene2499 0.0 1219.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3XZC8@572511|Blautia 186801|Clostridia KLT Psort location CytoplasmicMembrane, score prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase KKPNOBBG_00009 33035.JPJF01000002_gene2498 5.39e-194 540.0 COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,3XZER@572511|Blautia 186801|Clostridia S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N KKPNOBBG_00010 33035.JPJF01000002_gene2497 9.54e-140 397.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3XZY7@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim KKPNOBBG_00011 33035.JPJF01000002_gene2496 3.52e-143 405.0 COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,3Y05M@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 thiN - 2.7.6.2 ko:K00949 ko00730,ko01100,map00730,map01100 - R00619 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TPK_B1_binding,TPK_catalytic KKPNOBBG_00012 33035.JPJF01000002_gene2495 1.83e-256 704.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,3XZ6D@572511|Blautia 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C KKPNOBBG_00013 33035.JPJF01000002_gene2494 1.02e-180 506.0 COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,3XYMQ@572511|Blautia 186801|Clostridia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT KKPNOBBG_00015 33035.JPJF01000002_gene2492 1.31e-100 292.0 COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,3XZXK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 mraZ - - ko:K03925 - - - - ko00000 - - - MraZ KKPNOBBG_00016 33035.JPJF01000002_gene2491 8.54e-218 602.0 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,3XYP8@572511|Blautia 186801|Clostridia H Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 KKPNOBBG_00017 33035.JPJF01000002_gene2490 3e-103 299.0 2E3U8@1|root,32YRK@2|Bacteria,1VEYB@1239|Firmicutes,24QRX@186801|Clostridia,3Y079@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - DivIC KKPNOBBG_00018 33035.JPJF01000002_gene2489 0.0 1300.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3XZK3@572511|Blautia 186801|Clostridia M Cell division protein FtsI penicillin-binding protein 2 - - - ko:K08384 ko00550,map00550 - - - ko00000,ko00001,ko01011 - - - PBP_dimer,Transpeptidase KKPNOBBG_00019 33035.JPJF01000002_gene2488 0.0 1118.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,3XYPN@572511|Blautia 186801|Clostridia M COG COG0768 Cell division protein FtsI penicillin-binding protein 2 spoVD - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase KKPNOBBG_00020 33035.JPJF01000002_gene2487 6.94e-216 598.0 COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,3XZ7U@572511|Blautia 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 KKPNOBBG_00021 33035.JPJF01000002_gene2486 1.03e-298 818.0 COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3XYZG@572511|Blautia 186801|Clostridia M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M KKPNOBBG_00022 33035.JPJF01000002_gene2485 1e-241 669.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3XYGP@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score 10.00 ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE KKPNOBBG_00023 33035.JPJF01000002_gene2484 4.18e-267 734.0 COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,3XYUE@572511|Blautia 186801|Clostridia M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA2 - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase KKPNOBBG_00024 33035.JPJF01000002_gene2483 3.24e-161 460.0 COG1589@1|root,COG1589@2|Bacteria,1V34X@1239|Firmicutes,248RF@186801|Clostridia,3XZP0@572511|Blautia 186801|Clostridia M COG1589 Cell division septal protein - - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 KKPNOBBG_00025 33035.JPJF01000002_gene2482 1.27e-254 702.0 COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3XYK3@572511|Blautia 186801|Clostridia D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin KKPNOBBG_00026 33035.JPJF01000002_gene2481 1.19e-100 293.0 COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,3Y01J@572511|Blautia 186801|Clostridia H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC KKPNOBBG_00027 33035.JPJF01000002_gene2480 1.04e-109 316.0 COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,3Y02X@572511|Blautia 186801|Clostridia H Probable molybdopterin binding domain mog - - - - - - - - - - - MOSC,MoCF_biosynth KKPNOBBG_00028 33035.JPJF01000002_gene2479 4.83e-100 292.0 COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia,3Y07M@572511|Blautia 186801|Clostridia K RNA polymerase sigma-70 factor, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_00029 33035.JPJF01000002_gene2478 2.93e-186 528.0 2CB1E@1|root,32RSJ@2|Bacteria,1VAQ3@1239|Firmicutes,24GGP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00030 33035.JPJF01000002_gene2477 3.77e-145 415.0 COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,3XYQC@572511|Blautia 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N KKPNOBBG_00031 33035.JPJF01000002_gene2475 3.47e-150 426.0 COG0710@1|root,COG0710@2|Bacteria,1TSPN@1239|Firmicutes,249EX@186801|Clostridia,3XZNE@572511|Blautia 186801|Clostridia E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I,SKI KKPNOBBG_00032 33035.JPJF01000002_gene2474 2.44e-186 520.0 29ECG@1|root,301AF@2|Bacteria,1UY4W@1239|Firmicutes,24HI3@186801|Clostridia,3Y05C@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score spoIIGA - - ko:K06383 - - - - ko00000,ko01000,ko01002 - - - Peptidase_U4 KKPNOBBG_00033 33035.JPJF01000002_gene2473 1.22e-167 469.0 COG1191@1|root,COG1191@2|Bacteria,1TP3T@1239|Firmicutes,24A4T@186801|Clostridia,3XZGI@572511|Blautia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigE - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 KKPNOBBG_00034 33035.JPJF01000002_gene2471 4.93e-165 463.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,3XZSI@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_IclR,IclR KKPNOBBG_00035 33035.JPJF01000002_gene2470 3.41e-143 404.0 COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,248GA@186801|Clostridia,3XYI5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase KKPNOBBG_00036 33035.JPJF01000002_gene2469 2.77e-248 681.0 COG0524@1|root,COG0524@2|Bacteria,1TRRY@1239|Firmicutes,248Y3@186801|Clostridia,3XZNP@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB KKPNOBBG_00037 33035.JPJF01000002_gene2468 1.78e-239 659.0 COG0524@1|root,COG0524@2|Bacteria,1TQ9Q@1239|Firmicutes,25B0T@186801|Clostridia,3XYRS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB KKPNOBBG_00038 537007.BLAHAN_06683 9.36e-44 143.0 COG1873@1|root,COG1873@2|Bacteria,1VEMT@1239|Firmicutes,25P5S@186801|Clostridia,3Y0IV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PRC KKPNOBBG_00039 33035.JPJF01000055_gene1703 0.0 944.0 2AJ90@1|root,319TX@2|Bacteria,1V137@1239|Firmicutes,24BHQ@186801|Clostridia 186801|Clostridia S Glucosyl transferase GtrII - - - - - - - - - - - - Glucos_trans_II KKPNOBBG_00040 33035.JPJF01000055_gene1702 0.0 1008.0 COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,3Y0TG@572511|Blautia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminal domain - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C KKPNOBBG_00041 33035.JPJF01000055_gene1701 3.3e-175 491.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3XZFP@572511|Blautia 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA KKPNOBBG_00042 33035.JPJF01000055_gene1700 0.0 1241.0 COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3XYSJ@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 10.00 thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD KKPNOBBG_00043 33035.JPJF01000055_gene1699 2.77e-175 489.0 COG1191@1|root,COG1191@2|Bacteria,1TPDD@1239|Firmicutes,24A1H@186801|Clostridia,3XZ0B@572511|Blautia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigG - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 KKPNOBBG_00044 457412.RSAG_02295 1.36e-266 731.0 COG0673@1|root,COG0673@2|Bacteria,1V0MQ@1239|Firmicutes,24CZ7@186801|Clostridia,3WMEG@541000|Ruminococcaceae 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_00045 457412.RSAG_02296 2.46e-240 669.0 COG1653@1|root,COG1653@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_00046 1121115.AXVN01000038_gene3331 2.55e-181 508.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00047 457412.RSAG_02298 2.41e-163 461.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia,3WJF8@541000|Ruminococcaceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00048 457412.RSAG_02299 1.04e-242 689.0 COG2972@1|root,COG2972@2|Bacteria,1UZWA@1239|Firmicutes,24EGG@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - His_kinase KKPNOBBG_00049 1121115.AXVN01000038_gene3334 1.36e-180 522.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2J2@1239|Firmicutes,24CQK@186801|Clostridia,3Y1VC@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_00050 33035.JPJF01000055_gene1697 9.32e-49 158.0 COG0537@1|root,COG0537@2|Bacteria,1VCZW@1239|Firmicutes 1239|Firmicutes FG HIT domain - - 3.6.1.17 ko:K01518 ko00230,ko00240,map00230,map00240 - R00184,R00969,R01232,R02805 RC00002 ko00000,ko00001,ko01000 - - - HIT KKPNOBBG_00051 33035.JPJF01000055_gene1696 3.45e-118 338.0 299ND@1|root,2ZWQQ@2|Bacteria,1UZ92@1239|Firmicutes,24KDA@186801|Clostridia 186801|Clostridia S L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase KKPNOBBG_00052 33035.JPJF01000055_gene1695 7.33e-189 529.0 COG0454@1|root,COG0454@2|Bacteria,1V5SQ@1239|Firmicutes,24BQ5@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_00053 33035.JPJF01000055_gene1694 1.16e-221 614.0 COG1363@1|root,COG1363@2|Bacteria,1TQ86@1239|Firmicutes,25CDF@186801|Clostridia,3XYZU@572511|Blautia 186801|Clostridia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 KKPNOBBG_00054 33035.JPJF01000055_gene1693 1.14e-155 439.0 COG1738@1|root,COG1738@2|Bacteria,1TSAY@1239|Firmicutes,24EFG@186801|Clostridia 186801|Clostridia S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 KKPNOBBG_00055 33035.JPJF01000055_gene1692 6.33e-148 419.0 COG1244@1|root,COG1244@2|Bacteria,1UZ5M@1239|Firmicutes,24AIM@186801|Clostridia,3Y1MH@572511|Blautia 186801|Clostridia S Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - - KKPNOBBG_00056 33035.JPJF01000055_gene1691 1.53e-102 296.0 COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,3XZYK@572511|Blautia 186801|Clostridia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone KKPNOBBG_00057 33035.JPJF01000055_gene1690 0.0 994.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia 186801|Clostridia E Family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_00058 33035.JPJF01000055_gene1689 2.32e-189 529.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033,ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 KKPNOBBG_00059 33035.JPJF01000055_gene1688 9.37e-168 471.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia 186801|Clostridia P ABC-type dipeptide oligopeptide nickel transport - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_00060 33035.JPJF01000055_gene1687 4.79e-169 475.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3XZ1P@572511|Blautia 186801|Clostridia EP Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY KKPNOBBG_00061 33035.JPJF01000055_gene1686 2.71e-150 425.0 COG4608@1|root,COG4608@2|Bacteria,1V2IG@1239|Firmicutes,24GEF@186801|Clostridia 186801|Clostridia E ATPases associated with a variety of cellular activities - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran KKPNOBBG_00062 190304.FN1781 1.91e-40 157.0 COG0539@1|root,COG0761@1|root,COG1185@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,COG1185@2|Bacteria,378DH@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 KKPNOBBG_00063 33035.JPJF01000055_gene1685 2.69e-297 810.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,3XYYS@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,HTH_3 KKPNOBBG_00064 33035.JPJF01000055_gene1684 1.43e-183 513.0 COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,248I1@186801|Clostridia,3XYIR@572511|Blautia 186801|Clostridia EG Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - EamA KKPNOBBG_00065 33035.JPJF01000055_gene1683 1.23e-310 849.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3XYXR@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00067 33035.JPJF01000055_gene1681 4.09e-88 260.0 COG1846@1|root,COG1846@2|Bacteria,1VFS1@1239|Firmicutes,24QXV@186801|Clostridia,3Y0D8@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_00068 33035.JPJF01000055_gene1680 0.0 1280.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3XYTY@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_00069 33035.JPJF01000055_gene1679 0.0 1113.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3XZ2D@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_00071 33035.JPJF01000055_gene1678 5.57e-225 622.0 COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,3XZMW@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 aroF - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 KKPNOBBG_00072 33035.JPJF01000055_gene1677 0.0 1392.0 COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,3XYQH@572511|Blautia 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim KKPNOBBG_00073 33035.JPJF01000055_gene1676 2.54e-74 223.0 COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,3Y0CQ@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K21903 - - - - ko00000,ko03000 - - - HTH_5 KKPNOBBG_00074 33035.JPJF01000055_gene1675 0.0 887.0 COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,3XYZV@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt KKPNOBBG_00075 33035.JPJF01000055_gene1674 2e-115 331.0 COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,24KK7@186801|Clostridia,3XZXE@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yqeG - - ko:K07015 - - - - ko00000 - - - HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase KKPNOBBG_00076 33035.JPJF01000055_gene1673 5e-130 369.0 COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,3XZPQ@572511|Blautia 186801|Clostridia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C KKPNOBBG_00077 33035.JPJF01000055_gene1669 3.19e-188 525.0 28PM6@1|root,2ZCAA@2|Bacteria,1V4NT@1239|Firmicutes,24HIP@186801|Clostridia,3Y07Z@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_00079 33035.JPJF01000055_gene1668 2.15e-191 534.0 COG3103@1|root,COG4991@2|Bacteria,1VD2T@1239|Firmicutes,24RYA@186801|Clostridia,3Y03B@572511|Blautia 186801|Clostridia T Bacterial SH3 domain - - - - - - - - - - - - SH3_3 KKPNOBBG_00080 33035.JPJF01000055_gene1667 1.28e-177 520.0 COG0726@1|root,COG5263@1|root,COG0726@2|Bacteria,COG5263@2|Bacteria,1V6DN@1239|Firmicutes,249SN@186801|Clostridia,3XZX1@572511|Blautia 186801|Clostridia G Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - CW_binding_1,ChW,Polysacc_deac_1 KKPNOBBG_00081 33035.JPJF01000055_gene1666 1.77e-155 438.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,3XZ9V@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 rluF - 5.4.99.21,5.4.99.22 ko:K06178,ko:K06182 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 KKPNOBBG_00082 33035.JPJF01000055_gene1665 0.0 1204.0 COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,3XZ8K@572511|Blautia 186801|Clostridia L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 KKPNOBBG_00083 33035.JPJF01000055_gene1664 0.0 1012.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,3XZ8D@572511|Blautia 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N KKPNOBBG_00084 33035.JPJF01000096_gene2094 3.18e-206 571.0 COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,3XZIH@572511|Blautia 186801|Clostridia E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metAA - 2.3.1.46 ko:K00651 ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230 M00017 R01777 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS11970 HTS KKPNOBBG_00085 33035.JPJF01000096_gene2093 0.0 986.0 2DB9B@1|root,2Z7VY@2|Bacteria,1UHZN@1239|Firmicutes,24AP5@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4091 KKPNOBBG_00086 33035.JPJF01000096_gene2092 4.88e-67 206.0 28NY7@1|root,2ZBVG@2|Bacteria,1V2J3@1239|Firmicutes,24G35@186801|Clostridia,3Y06T@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF2992) - - - - - - - - - - - - DUF2992 KKPNOBBG_00087 1111454.HMPREF1250_1905 1.8e-75 235.0 COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,4H4SU@909932|Negativicutes 909932|Negativicutes G Belongs to the aspartate glutamate racemases family - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race KKPNOBBG_00088 33035.JPJF01000096_gene2091 0.0 1018.0 COG0753@1|root,COG0753@2|Bacteria,1TPPV@1239|Firmicutes,247Y1@186801|Clostridia 186801|Clostridia C Serves to protect cells from the toxic effects of hydrogen peroxide katA - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel KKPNOBBG_00089 411467.BACCAP_00543 0.0 1679.0 COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,2687J@186813|unclassified Clostridiales 186801|Clostridia C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS18410 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA KKPNOBBG_00090 33035.JPJF01000116_gene2597 0.0 1587.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3XYGW@572511|Blautia 186801|Clostridia F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN KKPNOBBG_00091 33035.JPJF01000116_gene2598 6.49e-245 673.0 COG0208@1|root,COG0208@2|Bacteria,1TQTH@1239|Firmicutes,249AN@186801|Clostridia,3XZSE@572511|Blautia 186801|Clostridia F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm KKPNOBBG_00092 33035.JPJF01000116_gene2599 1.06e-204 569.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3XYHF@572511|Blautia 186801|Clostridia GK Psort location Cytoplasmic, score - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK KKPNOBBG_00093 33035.JPJF01000116_gene2600 5.7e-299 818.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XYX6@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00094 33035.JPJF01000116_gene2601 2.39e-93 273.0 COG1846@1|root,COG1846@2|Bacteria,1VJU1@1239|Firmicutes,24JW2@186801|Clostridia 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - HTH_27 KKPNOBBG_00095 33035.JPJF01000116_gene2602 8.25e-159 448.0 COG1670@1|root,COG1670@2|Bacteria,1TQUK@1239|Firmicutes,24BF7@186801|Clostridia 186801|Clostridia J GNAT acetyltransferase - - - - - - - - - - - - GNAT_acetyltran KKPNOBBG_00096 33035.JPJF01000116_gene2603 3.85e-29 113.0 COG4372@1|root,COG4372@2|Bacteria,1UH4U@1239|Firmicutes,25PTF@186801|Clostridia,3Y23N@572511|Blautia 186801|Clostridia S Transposase - - - - - - - - - - - - - KKPNOBBG_00097 33035.JPJF01000116_gene2604 2.22e-175 491.0 COG0583@1|root,COG0583@2|Bacteria,1UXNN@1239|Firmicutes,25M7W@186801|Clostridia,3Y23K@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_00098 33035.JPJF01000116_gene2605 8.76e-267 734.0 COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,3XZ9R@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC KKPNOBBG_00099 33035.JPJF01000116_gene2606 0.0 1051.0 COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia,3XZ1S@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score ykpA - - - - - - - - - - - ABC_tran,ABC_tran_Xtn KKPNOBBG_00100 33035.JPJF01000116_gene2607 2.97e-86 254.0 COG1959@1|root,COG1959@2|Bacteria,1VA5B@1239|Firmicutes,24JMN@186801|Clostridia,3Y09T@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Rrf2 KKPNOBBG_00101 33035.JPJF01000116_gene2608 0.0 2314.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,3XZ4K@572511|Blautia 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C KKPNOBBG_00102 33035.JPJF01000116_gene2609 3.5e-78 233.0 COG3428@1|root,COG3428@2|Bacteria,1V9YB@1239|Firmicutes,24MQT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - bPH_2 KKPNOBBG_00103 33035.JPJF01000116_gene2610 2.55e-153 432.0 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,3XZZF@572511|Blautia 186801|Clostridia C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD KKPNOBBG_00104 537007.BLAHAN_06799 2.3e-122 352.0 COG0461@1|root,COG0461@2|Bacteria,1V23H@1239|Firmicutes,24FTS@186801|Clostridia,3XZRS@572511|Blautia 186801|Clostridia F orotate phosphoribosyltransferase K00762 - - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - - KKPNOBBG_00105 33035.JPJF01000007_gene2024 1.54e-148 425.0 2EC0M@1|root,30HYA@2|Bacteria,1UUUE@1239|Firmicutes,258KM@186801|Clostridia,3Y0WI@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00106 33035.JPJF01000007_gene2025 0.0 1837.0 COG1026@1|root,COG1026@2|Bacteria,1TPD1@1239|Firmicutes,25ACE@186801|Clostridia,3XZNB@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C KKPNOBBG_00107 33035.JPJF01000007_gene2026 5.31e-210 581.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,3XYUU@572511|Blautia 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 KKPNOBBG_00108 33035.JPJF01000007_gene2027 5.54e-166 465.0 COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,3XYR9@572511|Blautia 186801|Clostridia L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N KKPNOBBG_00109 33035.JPJF01000007_gene2028 0.0 962.0 COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3XZ0N@572511|Blautia 186801|Clostridia J Catalyzes the attachment of glycine to tRNA(Gly) glyQS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b KKPNOBBG_00110 33035.JPJF01000007_gene2029 1.77e-229 633.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3XZ8Q@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K02529,ko:K03484 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_00111 33035.JPJF01000007_gene2030 0.0 971.0 COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,247UU@186801|Clostridia,3Y12M@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 32 - - - - - - - - - - - - Glyco_hydro_32C,Glyco_hydro_32N KKPNOBBG_00112 33035.JPJF01000007_gene2031 7.24e-301 822.0 COG1653@1|root,COG1653@2|Bacteria,1TR8U@1239|Firmicutes,25E8A@186801|Clostridia,3XZJY@572511|Blautia 186801|Clostridia G ABC transporter periplasmic binding protein YcjN precursor - - - ko:K10120 - M00197 - - ko00000,ko00002,ko02000 3.A.1.1.20 - - SBP_bac_8 KKPNOBBG_00113 33035.JPJF01000007_gene2032 8e-197 547.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,249MK@186801|Clostridia,3XZBN@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 msmF - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00114 33035.JPJF01000007_gene2033 3.85e-197 546.0 COG0395@1|root,COG0395@2|Bacteria,1UCH2@1239|Firmicutes,24AS5@186801|Clostridia,3XZF4@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00115 1235792.C808_04536 1.6e-48 164.0 COG5578@1|root,COG5578@2|Bacteria,1UR5B@1239|Firmicutes,258Z6@186801|Clostridia,27MIH@186928|unclassified Lachnospiraceae 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 KKPNOBBG_00116 33035.JPJF01000007_gene2034 2.18e-13 67.8 COG1476@1|root,COG1476@2|Bacteria,1UUSK@1239|Firmicutes,247YW@186801|Clostridia,3Y062@572511|Blautia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3,Zn_ribbon_2 KKPNOBBG_00117 622312.ROSEINA2194_02111 2.6e-24 96.7 2DP7G@1|root,330V3@2|Bacteria,1VIP0@1239|Firmicutes,24WEJ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00118 1214166.ALLG01000010_gene1955 2.55e-215 593.0 2DB8K@1|root,2Z7S1@2|Bacteria,1TRA1@1239|Firmicutes,4HBIE@91061|Bacilli,1WT6Z@1307|Streptococcus suis 91061|Bacilli G Streptomycin adenylyltransferase aadK - - ko:K05593 - - - - ko00000,ko01000,ko01504 - - - Adenyl_transf KKPNOBBG_00119 1121864.OMO_01534 8.31e-76 231.0 COG0454@1|root,COG0456@2|Bacteria,1V6YX@1239|Firmicutes,4HJS1@91061|Bacilli,4B32K@81852|Enterococcaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_00120 471875.RUMLAC_00554 8.56e-178 496.0 COG1396@1|root,COG1396@2|Bacteria,1TT2N@1239|Firmicutes,2488F@186801|Clostridia,3WHQ4@541000|Ruminococcaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_00121 411462.DORLON_00490 6.32e-08 53.1 28NID@1|root,2ZBYW@2|Bacteria,1V1SS@1239|Firmicutes,257MZ@186801|Clostridia,27VT9@189330|Dorea 186801|Clostridia S Cysteine-rich VLP - - - - - - - - - - - - Cys_rich_VLP KKPNOBBG_00122 1235792.C808_03769 2.95e-92 270.0 28NID@1|root,2Z9XT@2|Bacteria,1V16A@1239|Firmicutes,24FUK@186801|Clostridia,27MT4@186928|unclassified Lachnospiraceae 186801|Clostridia S Cysteine-rich VLP - - - - - - - - - - - - Cys_rich_VLP KKPNOBBG_00123 471875.RUMLAC_00550 6.54e-222 612.0 COG1196@1|root,COG1196@2|Bacteria,1TRNI@1239|Firmicutes,247S8@186801|Clostridia,3WH31@541000|Ruminococcaceae 186801|Clostridia D Plasmid recombination enzyme - - - - - - - - - - - - Mob_Pre KKPNOBBG_00124 1211819.CALK01000032_gene2932 1.24e-39 131.0 2C3T4@1|root,32S28@2|Bacteria,1VB78@1239|Firmicutes,3VTWK@526524|Erysipelotrichia 526524|Erysipelotrichia - - - - - - - - - - - - - - - KKPNOBBG_00125 742743.HMPREF9453_00874 0.0 1068.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,4H5RF@909932|Negativicutes 909932|Negativicutes L Domain of unknown function (DUF4368) - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_00126 33035.JPJF01000007_gene2035 1.13e-99 295.0 COG0671@1|root,COG0671@2|Bacteria,1V7SI@1239|Firmicutes,24FWW@186801|Clostridia 186801|Clostridia I PAP2 superfamily - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 KKPNOBBG_00127 33035.JPJF01000007_gene2036 2.54e-247 687.0 COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,3XZ1F@572511|Blautia 186801|Clostridia M Bacterial capsule synthesis protein PGA_cap capA - - ko:K07282 - - - - ko00000 - - - PGA_cap KKPNOBBG_00128 33035.JPJF01000007_gene2037 2.7e-297 811.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,3XZA1@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK KKPNOBBG_00129 33035.JPJF01000007_gene2038 0.0 1117.0 COG2972@1|root,COG2972@2|Bacteria,1UYEW@1239|Firmicutes,24CU0@186801|Clostridia,3Y1BF@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_00130 33035.JPJF01000007_gene2039 6.9e-210 582.0 COG0407@1|root,COG0407@2|Bacteria,1U2YS@1239|Firmicutes,25NJV@186801|Clostridia,3Y1DD@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00131 33035.JPJF01000007_gene2040 9.81e-277 761.0 COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,3XZ5U@572511|Blautia 186801|Clostridia G ABC transporter periplasmic binding protein YcjN precursor - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_00132 33035.JPJF01000007_gene2041 1.02e-204 567.0 COG1175@1|root,COG1175@2|Bacteria,1TQB1@1239|Firmicutes,25C4P@186801|Clostridia,3XZG3@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_00133 33035.JPJF01000007_gene2042 3.66e-190 529.0 COG0395@1|root,COG0395@2|Bacteria,1UYHV@1239|Firmicutes,25C4Q@186801|Clostridia,3Y2EC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00134 33035.JPJF01000007_gene2043 1.31e-310 852.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQYB@1239|Firmicutes,24ERE@186801|Clostridia,3Y1DE@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_00135 33035.JPJF01000007_gene2044 8.88e-263 725.0 COG3681@1|root,COG3681@2|Bacteria,1TQF5@1239|Firmicutes,2488Q@186801|Clostridia,3XYV4@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score - - - - - - - - - - - - SDH_alpha KKPNOBBG_00136 33035.JPJF01000007_gene2045 5.81e-260 720.0 COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,3Y17X@572511|Blautia 186801|Clostridia E Peptidase family M20/M25/M40 - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 KKPNOBBG_00137 33035.JPJF01000007_gene2046 1.01e-200 558.0 COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,248NF@186801|Clostridia,3XZFK@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_00138 33035.JPJF01000007_gene2047 0.0 1720.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,3XZCJ@572511|Blautia 186801|Clostridia G Phosphoenolpyruvate synthase pyruvate phosphate dikinase ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N KKPNOBBG_00139 33035.JPJF01000007_gene2048 3.18e-242 671.0 COG2207@1|root,COG2207@2|Bacteria,1TQD7@1239|Firmicutes,24DSW@186801|Clostridia,3Y1J2@572511|Blautia 1239|Firmicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC KKPNOBBG_00140 33035.JPJF01000007_gene2050 0.0 3910.0 COG1196@1|root,COG5263@1|root,COG5520@1|root,COG1196@2|Bacteria,COG5263@2|Bacteria,COG5520@2|Bacteria,1UUUF@1239|Firmicutes,25KCG@186801|Clostridia,3Y1M0@572511|Blautia 186801|Clostridia DG FIVAR domain - - - - - - - - - - - - FIVAR KKPNOBBG_00141 33035.JPJF01000007_gene2051 4.48e-220 610.0 COG1609@1|root,COG1609@2|Bacteria,1TRWK@1239|Firmicutes,24DAV@186801|Clostridia,3Y29V@572511|Blautia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_00142 33035.JPJF01000007_gene2052 0.0 4445.0 COG1196@1|root,COG1409@1|root,COG3507@1|root,COG3533@1|root,COG4412@1|root,COG1196@2|Bacteria,COG1409@2|Bacteria,COG3507@2|Bacteria,COG3533@2|Bacteria,COG4412@2|Bacteria,1U157@1239|Firmicutes,25E8B@186801|Clostridia 186801|Clostridia U Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Big_4,FIVAR,Laminin_G_3 KKPNOBBG_00143 33035.JPJF01000007_gene2053 3.54e-167 467.0 COG0671@1|root,COG0671@2|Bacteria,1V2PZ@1239|Firmicutes,24DHR@186801|Clostridia,3Y014@572511|Blautia 186801|Clostridia I PAP2 superfamily - - - - - - - - - - - - PAP2_3 KKPNOBBG_00144 33035.JPJF01000007_gene2054 2.57e-230 636.0 COG0392@1|root,COG0392@2|Bacteria,1TXG8@1239|Firmicutes,24A1A@186801|Clostridia,3XZ24@572511|Blautia 186801|Clostridia S Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms mprF - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM KKPNOBBG_00145 33035.JPJF01000007_gene2055 8.79e-125 358.0 COG1183@1|root,COG1183@2|Bacteria,1TTB7@1239|Firmicutes,24GPU@186801|Clostridia,3XZVV@572511|Blautia 186801|Clostridia I CDP-alcohol phosphatidyltransferase - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf KKPNOBBG_00146 33035.JPJF01000007_gene2056 8.93e-192 534.0 COG0688@1|root,COG0688@2|Bacteria,1TR34@1239|Firmicutes,248VU@186801|Clostridia,3XYYF@572511|Blautia 186801|Clostridia I Phosphatidylserine decarboxylase psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase KKPNOBBG_00147 33035.JPJF01000007_gene2057 3.98e-169 475.0 COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,3XZBG@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 alkA - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,OGG_N KKPNOBBG_00148 33035.JPJF01000007_gene2058 1.05e-147 417.0 COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,3Y1KF@572511|Blautia 186801|Clostridia S MgtC family - - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC KKPNOBBG_00149 33035.JPJF01000007_gene2059 1.3e-143 410.0 COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1TPKH@1239|Firmicutes,249WN@186801|Clostridia 186801|Clostridia C PFAM Nitroreductase - - - - - - - - - - - - Fer4,Fer4_10,Fer4_4,Fer4_6,Nitroreductase KKPNOBBG_00150 33035.JPJF01000007_gene2060 6.84e-197 548.0 COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia,3Y0U0@572511|Blautia 186801|Clostridia K WYL domain - - - - - - - - - - - - HTH_11,WYL KKPNOBBG_00151 33035.JPJF01000007_gene2061 9.4e-89 262.0 COG3708@1|root,COG3708@2|Bacteria,1V7HJ@1239|Firmicutes,24KUR@186801|Clostridia 186801|Clostridia K PFAM Bacterial transcription activator, effector binding - - - - - - - - - - - - Cass2,Zn_ribbon_2 KKPNOBBG_00152 33035.JPJF01000007_gene2062 7.98e-123 352.0 COG0652@1|root,COG0652@2|Bacteria,1V1SP@1239|Firmicutes,24G4H@186801|Clostridia,3XZUZ@572511|Blautia 186801|Clostridia M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase KKPNOBBG_00153 33035.JPJF01000007_gene2063 6.05e-128 373.0 2DPUG@1|root,333EN@2|Bacteria,1VIIY@1239|Firmicutes,24QQ5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00154 33035.JPJF01000007_gene2064 0.0 994.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3Y16R@572511|Blautia 186801|Clostridia L DbpA RNA binding domain cshA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C KKPNOBBG_00155 33035.JPJF01000007_gene2065 0.0 1495.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3XZ46@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF5110) - - - - - - - - - - - - DUF4968,DUF5110,Glyco_hydro_31 KKPNOBBG_00156 33035.JPJF01000007_gene2066 3.84e-232 638.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3Y086@572511|Blautia 186801|Clostridia S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - DLH,FSH1,Hydrolase_4 KKPNOBBG_00157 33035.JPJF01000007_gene2067 7.66e-274 748.0 COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,3Y032@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Aldo_ket_red,Fer4,Fer4_17 KKPNOBBG_00158 33035.JPJF01000007_gene2068 1.38e-263 726.0 COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,3XZHU@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - - ko:K19955 - - - - ko00000,ko01000 - - - Fe-ADH KKPNOBBG_00159 33035.JPJF01000007_gene2069 1.05e-174 487.0 COG1342@1|root,COG1433@1|root,COG1342@2|Bacteria,COG1433@2|Bacteria,1TRMQ@1239|Firmicutes,25E8C@186801|Clostridia,3XZY2@572511|Blautia 186801|Clostridia S Dinitrogenase iron-molybdenum cofactor - - - - - - - - - - - - DUF134,Nitro_FeMo-Co KKPNOBBG_00160 33035.JPJF01000007_gene2070 4.05e-119 340.0 COG2032@1|root,COG2032@2|Bacteria,1V3HM@1239|Firmicutes,24HGH@186801|Clostridia,3Y1RM@572511|Blautia 186801|Clostridia P Copper/zinc superoxide dismutase (SODC) sodC - 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu KKPNOBBG_00161 33035.JPJF01000007_gene2071 3.02e-101 293.0 COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,3XYJ2@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 cotJC - - ko:K06334 - - - - ko00000 - - - Mn_catalase KKPNOBBG_00162 33035.JPJF01000073_gene4416 1.71e-140 407.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00163 33035.JPJF01000073_gene4414 2.89e-58 208.0 COG2508@1|root,COG2508@2|Bacteria,1VIT3@1239|Firmicutes,24JXW@186801|Clostridia,3Y0T9@572511|Blautia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_00164 33035.JPJF01000047_gene905 2.38e-127 362.0 COG5423@1|root,COG5423@2|Bacteria,1V8BX@1239|Firmicutes,24JN8@186801|Clostridia 186801|Clostridia S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 KKPNOBBG_00165 33035.JPJF01000047_gene904 4.69e-212 590.0 COG1940@1|root,COG1940@2|Bacteria,1V1AM@1239|Firmicutes,25B1Z@186801|Clostridia 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK KKPNOBBG_00166 33035.JPJF01000047_gene903 5.12e-261 721.0 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - MFS_1 KKPNOBBG_00167 33035.JPJF01000047_gene902 5.98e-167 472.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia 186801|Clostridia S PHP domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP KKPNOBBG_00168 33035.JPJF01000047_gene901 0.0 1325.0 COG1653@1|root,COG1653@2|Bacteria,1TPM0@1239|Firmicutes,24ARZ@186801|Clostridia,3Y168@572511|Blautia 186801|Clostridia G Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF1565 KKPNOBBG_00169 33035.JPJF01000047_gene900 2.32e-210 582.0 COG2207@1|root,COG2207@2|Bacteria,1UYSR@1239|Firmicutes,248R9@186801|Clostridia,3Y2A2@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_00170 33035.JPJF01000047_gene899 0.0 869.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3XZ7Z@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00171 33035.JPJF01000047_gene896 6.87e-153 430.0 COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,3Y0CT@572511|Blautia 186801|Clostridia K FCD - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR KKPNOBBG_00172 33035.JPJF01000047_gene895 3.48e-309 841.0 COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,3Y0NS@572511|Blautia 186801|Clostridia M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - 4.2.1.5 ko:K01683 - - - - ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N KKPNOBBG_00173 33035.JPJF01000047_gene894 1.51e-216 600.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,3Y06Q@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_00174 33035.JPJF01000047_gene893 4.51e-101 294.0 COG3090@1|root,COG3090@2|Bacteria 2|Bacteria G Trap-type c4-dicarboxylate transport system, small permease component - - - ko:K11689 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctQ KKPNOBBG_00175 33035.JPJF01000047_gene892 1.05e-291 798.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,3XZAD@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM KKPNOBBG_00176 33035.JPJF01000047_gene891 7.76e-245 673.0 COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,3Y2DN@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - 1.1.1.380 ko:K08322 ko00040,ko01100,map00040,map01100 - R10848 RC00085 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_00177 33035.JPJF01000047_gene890 6.94e-182 506.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,3Y15M@572511|Blautia 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase kduD - 1.1.1.127,1.1.1.69 ko:K00046,ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 KKPNOBBG_00178 33035.JPJF01000047_gene889 8.97e-38 127.0 2A2DC@1|root,30QQD@2|Bacteria,1UGEZ@1239|Firmicutes,25NVE@186801|Clostridia,3Y22X@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00180 33035.JPJF01000047_gene887 6.04e-290 803.0 COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,248J7@186801|Clostridia,3XYZX@572511|Blautia 186801|Clostridia L COG COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_00181 33035.JPJF01000047_gene886 4.69e-39 132.0 COG3546@1|root,COG3546@2|Bacteria,1UF7I@1239|Firmicutes,25K8A@186801|Clostridia,3Y21Y@572511|Blautia 186801|Clostridia P Manganese containing catalase - - - - - - - - - - - - Mn_catalase KKPNOBBG_00182 33035.JPJF01000047_gene885 1.99e-57 177.0 2E34J@1|root,32Y4N@2|Bacteria,1VESM@1239|Firmicutes,24QZX@186801|Clostridia,3Y0NH@572511|Blautia 186801|Clostridia S COG NOG18028 non supervised orthologous group cotJB - - ko:K06333 - - - - ko00000 - - - CotJB KKPNOBBG_00183 33035.JPJF01000047_gene884 1.24e-59 184.0 2EHCX@1|root,33B4S@2|Bacteria,1VKA0@1239|Firmicutes,259R7@186801|Clostridia,3Y0T8@572511|Blautia 186801|Clostridia S Spore coat associated protein JA (CotJA) - - - - - - - - - - - - CotJA KKPNOBBG_00184 33035.JPJF01000047_gene883 9.43e-317 863.0 COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3XZFD@572511|Blautia 186801|Clostridia H AMP-binding enzyme C-terminal domain paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 KKPNOBBG_00185 33035.JPJF01000047_gene882 6.05e-98 285.0 COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,3Y2DE@572511|Blautia 186801|Clostridia S ACT domain - - - - - - - - - - - - ACT KKPNOBBG_00186 33035.JPJF01000047_gene881 7.2e-120 342.0 2C2RJ@1|root,33VFU@2|Bacteria,1VV8Z@1239|Firmicutes,250DV@186801|Clostridia,3Y08E@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00187 33035.JPJF01000047_gene880 0.0 1116.0 COG0584@1|root,COG0584@2|Bacteria,1UGF1@1239|Firmicutes,25E4R@186801|Clostridia,3Y139@572511|Blautia 186801|Clostridia C Membrane domain of glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,GPDPase_memb KKPNOBBG_00188 33035.JPJF01000047_gene879 5.6e-273 749.0 COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3XYUT@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score 10.00 ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE KKPNOBBG_00189 33035.JPJF01000047_gene878 9.9e-42 137.0 COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,3Y0HG@572511|Blautia 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding KKPNOBBG_00190 33035.JPJF01000047_gene877 5.26e-193 539.0 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,3XZKW@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 KKPNOBBG_00191 33035.JPJF01000047_gene876 1.1e-154 436.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 KKPNOBBG_00192 33035.JPJF01000047_gene875 6.33e-294 802.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3XZBB@572511|Blautia 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt KKPNOBBG_00193 33035.JPJF01000047_gene874 8.45e-101 293.0 COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,24MNP@186801|Clostridia,3Y0FB@572511|Blautia 186801|Clostridia I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB - - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - iHN637.CLJU_RS20755 Biotin_lipoyl KKPNOBBG_00194 33035.JPJF01000047_gene873 4.28e-92 270.0 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,3Y04Q@572511|Blautia 186801|Clostridia I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA KKPNOBBG_00195 33035.JPJF01000047_gene872 3.82e-315 859.0 COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,3XZMB@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 KKPNOBBG_00196 537007.BLAHAN_05168 7.55e-300 832.0 COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1TP4U@1239|Firmicutes,248QK@186801|Clostridia,3XYX8@572511|Blautia 186801|Clostridia I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01962,ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20740 ACCA,Carboxyl_trans KKPNOBBG_00197 33035.JPJF01000026_gene2724 7.28e-240 660.0 COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,3XZHK@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - NMO KKPNOBBG_00198 33035.JPJF01000026_gene2723 1.41e-52 166.0 2BAVH@1|root,324B1@2|Bacteria,1UQMR@1239|Firmicutes,24UDK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00199 33035.JPJF01000026_gene2722 0.0 1087.0 COG3525@1|root,COG3525@2|Bacteria,1TRN0@1239|Firmicutes,24CTA@186801|Clostridia,3Y0RI@572511|Blautia 186801|Clostridia G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - Glyco_hydro_20 KKPNOBBG_00200 556261.HMPREF0240_00897 1.41e-254 706.0 COG1653@1|root,COG1653@2|Bacteria,1TRMK@1239|Firmicutes,24BMJ@186801|Clostridia,36GI7@31979|Clostridiaceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_00201 556261.HMPREF0240_00898 1.77e-123 358.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24FGY@186801|Clostridia,36GPE@31979|Clostridiaceae 186801|Clostridia K response regulator - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_00202 1232453.BAIF02000087_gene265 5.3e-232 660.0 COG2972@1|root,COG2972@2|Bacteria,1TS61@1239|Firmicutes,247ZZ@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase KKPNOBBG_00203 556261.HMPREF0240_00900 5.99e-163 461.0 COG1175@1|root,COG1175@2|Bacteria,1UEPI@1239|Firmicutes,25C57@186801|Clostridia,36WPS@31979|Clostridiaceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00204 556261.HMPREF0240_00901 2.75e-154 438.0 COG0395@1|root,COG0395@2|Bacteria,1TSJK@1239|Firmicutes,25C5J@186801|Clostridia,36WPT@31979|Clostridiaceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00205 556261.HMPREF0240_00902 0.0 1173.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia,36FJR@31979|Clostridiaceae 186801|Clostridia G Domain of unknown function (DUF5110) - - - - - - - - - - - - DUF5110,Glyco_hydro_31 KKPNOBBG_00206 556261.HMPREF0240_00903 7.96e-256 704.0 COG5012@1|root,COG5012@2|Bacteria,1UF8A@1239|Firmicutes,24CAU@186801|Clostridia 186801|Clostridia S cobalamin binding - - - - - - - - - - - - - KKPNOBBG_00207 33035.JPJF01000026_gene2719 1.55e-293 803.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,3XZ7R@572511|Blautia 186801|Clostridia F COG COG0402 Cytosine deaminase and related metal-dependent hydrolases guaD - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 KKPNOBBG_00208 33035.JPJF01000026_gene2718 0.0 1469.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3XZHI@572511|Blautia 186801|Clostridia C COG COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs xdhA - 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 KKPNOBBG_00209 33035.JPJF01000026_gene2717 3.15e-184 515.0 COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia,3XZ4A@572511|Blautia 186801|Clostridia C COG COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs xdhB - 1.17.1.4 ko:K13479 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 KKPNOBBG_00210 33035.JPJF01000026_gene2716 3.5e-112 322.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24FZI@186801|Clostridia,3XZZI@572511|Blautia 186801|Clostridia C COG COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs cutS - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 KKPNOBBG_00211 33035.JPJF01000026_gene2710 3.59e-59 192.0 COG2207@1|root,COG2207@2|Bacteria,1V2Q5@1239|Firmicutes,24GBK@186801|Clostridia 186801|Clostridia K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_00212 1280671.AUJH01000003_gene1363 4.17e-45 156.0 COG2207@1|root,COG2207@2|Bacteria,1V2Q5@1239|Firmicutes,24GBK@186801|Clostridia 186801|Clostridia K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_00213 1280671.AUJH01000003_gene1364 8.89e-230 644.0 COG1653@1|root,COG1653@2|Bacteria,1U0QV@1239|Firmicutes,24BVP@186801|Clostridia,4BYQK@830|Butyrivibrio 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_00214 1280671.AUJH01000003_gene1365 4.76e-178 500.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia,4BWU0@830|Butyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00215 1280671.AUJH01000003_gene1366 8.3e-165 465.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,4C1Y3@830|Butyrivibrio 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00216 180332.JTGN01000009_gene4322 4.67e-31 120.0 COG5578@1|root,COG5578@2|Bacteria,1VI97@1239|Firmicutes,24TB6@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 KKPNOBBG_00217 658086.HMPREF0994_01166 7.38e-258 729.0 COG3533@1|root,COG3533@2|Bacteria,1TRI1@1239|Firmicutes,248CA@186801|Clostridia,27KWK@186928|unclassified Lachnospiraceae 186801|Clostridia N Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Big_4,Glyco_hydro_127,Laminin_G_3 KKPNOBBG_00218 33035.JPJF01000026_gene2715 0.0 927.0 COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3XZIU@572511|Blautia 186801|Clostridia H Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17,6.1.1.24 ko:K01885,ko:K09698 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R03651,R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c KKPNOBBG_00219 33035.JPJF01000026_gene2714 0.0 1179.0 COG0210@1|root,COG0210@2|Bacteria,1TPVG@1239|Firmicutes,2484I@186801|Clostridia,3XYTS@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 yjcD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C KKPNOBBG_00220 33035.JPJF01000026_gene2713 5.1e-113 327.0 COG2091@1|root,COG2091@2|Bacteria,1UFUD@1239|Firmicutes,25MRV@186801|Clostridia,3Y03Q@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 sfp - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS KKPNOBBG_00221 33035.JPJF01000026_gene2712 1.96e-227 627.0 COG0667@1|root,COG0667@2|Bacteria,1TRS0@1239|Firmicutes,247RJ@186801|Clostridia,3XZQB@572511|Blautia 186801|Clostridia C Aldo/keto reductase family - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red KKPNOBBG_00222 33035.JPJF01000026_gene2711 4.47e-56 178.0 COG0789@1|root,COG0789@2|Bacteria,1V6C0@1239|Firmicutes,24KFZ@186801|Clostridia,3Y0SI@572511|Blautia 186801|Clostridia K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 KKPNOBBG_00223 33035.JPJF01000026_gene2710 2.59e-184 516.0 COG2207@1|root,COG2207@2|Bacteria,1V2Q5@1239|Firmicutes,24GBK@186801|Clostridia 186801|Clostridia K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_00224 33035.JPJF01000026_gene2709 0.0 1260.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia 186801|Clostridia G protein conserved in bacteria - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 KKPNOBBG_00225 33035.JPJF01000026_gene2708 9.44e-73 222.0 COG1896@1|root,COG1896@2|Bacteria,1V4MY@1239|Firmicutes,25CES@186801|Clostridia,3Y0P3@572511|Blautia 186801|Clostridia S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 KKPNOBBG_00226 33035.JPJF01000026_gene2707 1.34e-230 635.0 COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia,3XYN0@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 spoIIIAA - - ko:K06390 - - - - ko00000 - - - T2SSE KKPNOBBG_00227 33035.JPJF01000026_gene2706 5.2e-103 300.0 2CEWW@1|root,3181X@2|Bacteria,1U7IP@1239|Firmicutes,2590I@186801|Clostridia,3Y0MY@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06391 - - - - ko00000 - - - Spore_III_AB KKPNOBBG_00228 33035.JPJF01000026_gene2705 1.35e-34 118.0 2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia,3Y0M5@572511|Blautia 186801|Clostridia S COG NOG17863 non supervised orthologous group spoIIIAC - - ko:K06392 - - - - ko00000 - - - SpoIIIAC KKPNOBBG_00229 33035.JPJF01000026_gene2704 2.8e-79 236.0 2CPUI@1|root,32SJW@2|Bacteria,1VA9Y@1239|Firmicutes,24NK6@186801|Clostridia,3Y0FF@572511|Blautia 186801|Clostridia S COG NOG13205 non supervised orthologous group spoIIIAD - - ko:K06393 - - - - ko00000 - - - SpoIIIAC KKPNOBBG_00230 33035.JPJF01000026_gene2703 6.13e-236 660.0 2C2CG@1|root,2Z7PW@2|Bacteria,1TQQ2@1239|Firmicutes,24AH2@186801|Clostridia,3XYI3@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score spoIIIAE - - ko:K06394 - - - - ko00000 - - - Spore_III_AE KKPNOBBG_00231 33035.JPJF01000026_gene2702 2.04e-67 205.0 2E7KE@1|root,3322G@2|Bacteria,1VKPT@1239|Firmicutes,24SKX@186801|Clostridia,3Y0SD@572511|Blautia 186801|Clostridia S COG NOG13844 non supervised orthologous group - - - ko:K06395 - - - - ko00000 - - - Spore_III_AF KKPNOBBG_00232 33035.JPJF01000026_gene2701 1.62e-87 259.0 2E6BB@1|root,330Z5@2|Bacteria,1VF3M@1239|Firmicutes,24RAX@186801|Clostridia,3Y0J8@572511|Blautia 186801|Clostridia S COG NOG11553 non supervised orthologous group spoIIIAG - - ko:K06396 - - - - ko00000 - - - - KKPNOBBG_00233 33035.JPJF01000026_gene2700 5.13e-135 388.0 2E3US@1|root,32YS3@2|Bacteria,1VESK@1239|Firmicutes,24R9H@186801|Clostridia,3Y02H@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score spoIIIAH - - ko:K06397 - - - - ko00000 1.A.34.1.1 - - SpoIIIAH KKPNOBBG_00234 33035.JPJF01000026_gene2699 0.0 1033.0 COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,3XZKH@572511|Blautia 186801|Clostridia J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C KKPNOBBG_00235 33035.JPJF01000026_gene2698 3.67e-120 343.0 COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,3Y0DK@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07043 - - - - ko00000 - - - DUF45 KKPNOBBG_00236 33035.JPJF01000026_gene2697 1.92e-163 459.0 COG3640@1|root,COG3640@2|Bacteria,1UZHR@1239|Firmicutes,24BYR@186801|Clostridia,3XYW4@572511|Blautia 186801|Clostridia D Anion-transporting ATPase - - - ko:K07321 - - - - ko00000 - - - AAA_31,CbiA KKPNOBBG_00237 33035.JPJF01000026_gene2696 8.13e-279 763.0 COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,3Y0XX@572511|Blautia 186801|Clostridia E 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - - HGD-D KKPNOBBG_00238 33035.JPJF01000026_gene2695 0.0 1106.0 COG1775@1|root,COG1775@2|Bacteria,1TS7H@1239|Firmicutes,2493U@186801|Clostridia,3Y0V9@572511|Blautia 186801|Clostridia E 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - - HGD-D KKPNOBBG_00239 33035.JPJF01000026_gene2694 6.56e-181 504.0 COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,3Y04S@572511|Blautia 186801|Clostridia I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG KKPNOBBG_00241 33035.JPJF01000026_gene2692 2.32e-147 417.0 COG1614@1|root,COG1614@2|Bacteria,1V37P@1239|Firmicutes,24KHT@186801|Clostridia,3Y1QJ@572511|Blautia 186801|Clostridia C CO dehydrogenase/acetyl-CoA synthase complex beta subunit - - - - - - - - - - - - CdhC KKPNOBBG_00242 33035.JPJF01000026_gene2691 0.0 1501.0 COG0493@1|root,COG1902@1|root,COG0493@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3Y1FD@572511|Blautia 186801|Clostridia C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_00243 33035.JPJF01000026_gene2690 7.21e-81 240.0 COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia,3Y075@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 asp - - - - - - - - - - - Asp23 KKPNOBBG_00244 33035.JPJF01000026_gene2689 2.69e-77 231.0 COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,3Y08R@572511|Blautia 186801|Clostridia K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB KKPNOBBG_00245 33035.JPJF01000026_gene2688 4.72e-237 659.0 COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3XZS9@572511|Blautia 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 KKPNOBBG_00246 33035.JPJF01000026_gene2687 4.68e-39 130.0 COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,24UH5@186801|Clostridia,3Y0QF@572511|Blautia 186801|Clostridia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S KKPNOBBG_00247 33035.JPJF01000026_gene2686 1.35e-186 521.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3XZAH@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 9.98 ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - iHN637.CLJU_RS05465 polyprenyl_synt KKPNOBBG_00248 33035.JPJF01000026_gene2685 0.0 1182.0 COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,3XYQF@572511|Blautia 186801|Clostridia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C KKPNOBBG_00249 33035.JPJF01000026_gene2684 4.99e-183 510.0 COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,3XZ0P@572511|Blautia 186801|Clostridia J ribosomal RNA large subunit methyltransferase J rrmJ - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 KKPNOBBG_00250 33035.JPJF01000026_gene2683 6.39e-199 551.0 COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,3XZAI@572511|Blautia 186801|Clostridia H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS05480 NAD_kinase KKPNOBBG_00251 33035.JPJF01000026_gene2682 9.03e-103 298.0 COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,3Y063@572511|Blautia 186801|Clostridia K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C KKPNOBBG_00252 33035.JPJF01000026_gene2681 0.0 998.0 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,3XZKD@572511|Blautia 186801|Clostridia L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N KKPNOBBG_00253 33035.JPJF01000026_gene2680 6.93e-266 729.0 COG3480@1|root,COG3480@2|Bacteria,1UI0S@1239|Firmicutes,25E9E@186801|Clostridia,3XZ8A@572511|Blautia 186801|Clostridia T stage IV sporulation protein B spoIVB - 3.4.21.116 ko:K06399 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S55 KKPNOBBG_00254 33035.JPJF01000026_gene2679 1.96e-182 508.0 COG2201@1|root,COG2201@2|Bacteria,1VQS3@1239|Firmicutes,25E3X@186801|Clostridia,3XYUD@572511|Blautia 186801|Clostridia NT May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process spo0A - - ko:K03413,ko:K07699 ko02020,ko02024,ko02030,map02020,map02024,map02030 M00485,M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg,Spo0A_C KKPNOBBG_00255 33035.JPJF01000026_gene2678 0.0 972.0 COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,3XYMY@572511|Blautia 186801|Clostridia G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 KKPNOBBG_00256 33035.JPJF01000026_gene2677 1.9e-141 402.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00257 33035.JPJF01000026_gene2676 1.01e-212 591.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,3Y000@572511|Blautia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_00258 33035.JPJF01000026_gene2675 0.0 1414.0 COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,3XZ97@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 9.98 cdr - - - - - - - - - - - DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA KKPNOBBG_00259 33035.JPJF01000025_gene2673 0.0 1152.0 COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3XZQ4@572511|Blautia 186801|Clostridia C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase KKPNOBBG_00260 33035.JPJF01000025_gene2672 3.02e-173 484.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,3XZDV@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score bceA - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00261 33035.JPJF01000025_gene2671 0.0 1128.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3Y18J@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_00262 33035.JPJF01000025_gene2670 8.73e-32 111.0 2E6Q9@1|root,331AH@2|Bacteria,1VETD@1239|Firmicutes,24REB@186801|Clostridia,3Y0QY@572511|Blautia 186801|Clostridia S Psort location Extracellular, score 8.82 - - - - - - - - - - - - - KKPNOBBG_00263 33035.JPJF01000025_gene2669 3.11e-47 152.0 COG5577@1|root,COG5577@2|Bacteria,1VGMH@1239|Firmicutes,24QT7@186801|Clostridia,3Y0E8@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Coat_F KKPNOBBG_00264 33035.JPJF01000025_gene2668 1.62e-227 632.0 COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,3XZ9Q@572511|Blautia 186801|Clostridia L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA KKPNOBBG_00265 33035.JPJF01000025_gene2667 4.07e-122 350.0 COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24J7X@186801|Clostridia,3Y0I4@572511|Blautia 186801|Clostridia S Regulatory protein RecX recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX KKPNOBBG_00266 33035.JPJF01000025_gene2666 0.0 915.0 COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,3XZ66@572511|Blautia 186801|Clostridia S Endoribonuclease that initiates mRNA decay rny - - ko:K18682 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DUF3552,HD,KH_1 KKPNOBBG_00267 537007.BLAHAN_05205 1.24e-45 155.0 2EKG7@1|root,33E68@2|Bacteria,1VYC7@1239|Firmicutes 1239|Firmicutes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - SpoIIM KKPNOBBG_00268 33035.JPJF01000025_gene2664 9.48e-205 567.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,3XZAM@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase KKPNOBBG_00269 33035.JPJF01000025_gene2663 9.67e-250 685.0 COG0722@1|root,COG0722@2|Bacteria,1TQI4@1239|Firmicutes,24842@186801|Clostridia,3XYX3@572511|Blautia 186801|Clostridia E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroH - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS07240 DAHP_synth_1 KKPNOBBG_00270 33035.JPJF01000025_gene2662 2.86e-304 831.0 COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,3XZ1Z@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 spoVB - - ko:K06409 - - - - ko00000,ko02000 2.A.66.2.14 - - Polysacc_synt,Polysacc_synt_C KKPNOBBG_00271 33035.JPJF01000025_gene2661 2.68e-97 284.0 COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,3Y0AW@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 iscR - - - - - - - - - - - Rrf2 KKPNOBBG_00272 33035.JPJF01000025_gene2660 9.31e-273 748.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3XZ67@572511|Blautia 186801|Clostridia E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 KKPNOBBG_00273 33035.JPJF01000025_gene2659 7.07e-97 282.0 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,3XZVP@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 nifU - - ko:K04488 - - - - ko00000 - - - NifU_N KKPNOBBG_00274 33035.JPJF01000025_gene2658 1.88e-250 688.0 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3XZBE@572511|Blautia 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans KKPNOBBG_00275 33035.JPJF01000025_gene2657 1.06e-98 292.0 COG0454@1|root,COG0456@2|Bacteria,1VBWD@1239|Firmicutes,24NNB@186801|Clostridia 186801|Clostridia K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 KKPNOBBG_00276 33035.JPJF01000025_gene2656 4.3e-187 520.0 COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,249TM@186801|Clostridia,3XZF9@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 hisK - 3.1.3.15 ko:K04486 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PHP KKPNOBBG_00277 33035.JPJF01000025_gene2655 7.48e-239 657.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,3XZGK@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N KKPNOBBG_00278 33035.JPJF01000025_gene2654 1.41e-283 775.0 COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,3XYK6@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score pgk - 2.7.2.3,5.3.1.1 ko:K00927,ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01015,R01512 RC00002,RC00043,RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK KKPNOBBG_00279 33035.JPJF01000025_gene2653 1.05e-174 487.0 COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,3XYGS@572511|Blautia 186801|Clostridia G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS19265 TIM KKPNOBBG_00280 33035.JPJF01000025_gene2652 1.95e-204 567.0 COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,3XZB3@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 PflX - 1.97.1.4 ko:K04070 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM KKPNOBBG_00281 33035.JPJF01000025_gene2651 5.04e-311 852.0 COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,3Y14Z@572511|Blautia 186801|Clostridia S L,D-transpeptidase catalytic domain - - - - - - - - - - - - PG_binding_4,YkuD KKPNOBBG_00282 33035.JPJF01000025_gene2650 2.97e-170 477.0 COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,3XYTF@572511|Blautia 186801|Clostridia ET COG COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain artP - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 KKPNOBBG_00283 33035.JPJF01000025_gene2649 1.83e-118 343.0 COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,3XZT5@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 ArtM - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1,SBP_bac_3 KKPNOBBG_00284 33035.JPJF01000025_gene2648 4.09e-166 465.0 COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,3XZ1I@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.49 glnQ - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran KKPNOBBG_00285 33035.JPJF01000025_gene2647 0.0 985.0 COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3XZ21@572511|Blautia 186801|Clostridia G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N KKPNOBBG_00286 33035.JPJF01000025_gene2646 1.92e-193 538.0 COG4977@1|root,COG4977@2|Bacteria,1V5CN@1239|Firmicutes,25E9D@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_00287 33035.JPJF01000025_gene2645 0.0 871.0 COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00288 33035.JPJF01000025_gene2644 0.0 1197.0 COG3087@1|root,COG4932@1|root,COG3087@2|Bacteria,COG4932@2|Bacteria,1VDGY@1239|Firmicutes,253AP@186801|Clostridia 186801|Clostridia M domain protein - - - - - - - - - - - - - KKPNOBBG_00289 33035.JPJF01000025_gene2643 7.47e-104 303.0 2B21K@1|root,31UIF@2|Bacteria,1TUKE@1239|Firmicutes,25PUX@186801|Clostridia,3Y214@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00290 33035.JPJF01000025_gene2642 3.99e-130 372.0 2BJ2J@1|root,32DB9@2|Bacteria,1TUKD@1239|Firmicutes,25J0I@186801|Clostridia,3Y24I@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00291 33035.JPJF01000025_gene2641 2.01e-93 275.0 COG0681@1|root,COG0681@2|Bacteria,1VH82@1239|Firmicutes,259N9@186801|Clostridia,3Y23E@572511|Blautia 186801|Clostridia U Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 KKPNOBBG_00292 33035.JPJF01000025_gene2640 2.1e-151 427.0 2CN13@1|root,32SG0@2|Bacteria,1VBIH@1239|Firmicutes,24Q0G@186801|Clostridia,3Y1YK@572511|Blautia 186801|Clostridia S Camelysin metallo-endopeptidase - - - - - - - - - - - - Peptidase_M73 KKPNOBBG_00293 33035.JPJF01000025_gene2639 2.78e-309 843.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,3XYIB@572511|Blautia 186801|Clostridia H Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N KKPNOBBG_00294 537007.BLAHAN_05226 5.26e-36 123.0 COG1314@1|root,COG1314@2|Bacteria,1VG46@1239|Firmicutes,25N7Q@186801|Clostridia,3Y0K4@572511|Blautia 186801|Clostridia U Preprotein translocase SecG subunit secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG KKPNOBBG_00295 33035.JPJF01000025_gene2637 0.0 1357.0 COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,3XZBT@572511|Blautia 186801|Clostridia K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 KKPNOBBG_00296 33035.JPJF01000025_gene2636 2.06e-103 299.0 COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,3XZU0@572511|Blautia 186801|Clostridia O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB KKPNOBBG_00297 33035.JPJF01000025_gene2635 0.0 1031.0 COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,3XZPT@572511|Blautia 186801|Clostridia E oligoendopeptidase, M3 family pz-A - - - - - - - - - - - Peptidase_M3 KKPNOBBG_00298 33035.JPJF01000025_gene2634 4.25e-152 437.0 COG0842@1|root,COG0842@2|Bacteria,1TPJM@1239|Firmicutes,24BZX@186801|Clostridia 186801|Clostridia V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 KKPNOBBG_00299 33035.JPJF01000025_gene2633 7.9e-169 479.0 COG0842@1|root,COG0842@2|Bacteria,1TQ6H@1239|Firmicutes,24A0U@186801|Clostridia 186801|Clostridia V Transport permease protein - - - - - - - - - - - - ABC2_membrane_3 KKPNOBBG_00300 33035.JPJF01000025_gene2632 2.87e-170 479.0 COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,248WG@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K01990,ko:K16907 ko02010,map02010 M00224,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00301 1235802.C823_06042 2.75e-17 73.9 2EKZT@1|root,33EP9@2|Bacteria,1VNB4@1239|Firmicutes,24UNM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00302 33035.JPJF01000025_gene2630 1.43e-187 528.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_00303 33035.JPJF01000025_gene2629 4.61e-146 412.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00305 33035.JPJF01000025_gene2627 7.21e-72 216.0 COG2201@1|root,COG2201@2|Bacteria 2|Bacteria NT protein-glutamate methylesterase activity - - 3.1.1.61,3.5.1.44 ko:K02282,ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035,ko02044 - - - CheB_methylest,Response_reg,Spo0A_C KKPNOBBG_00307 33035.JPJF01000025_gene2626 1.04e-129 374.0 COG4395@1|root,COG4395@2|Bacteria,1V9GZ@1239|Firmicutes,24HB5@186801|Clostridia,3Y1KI@572511|Blautia 186801|Clostridia S Tim44 - - - - - - - - - - - - Tim44 KKPNOBBG_00308 33035.JPJF01000025_gene2625 1.06e-157 442.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,3XZ4H@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 srrA_6 - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00309 33035.JPJF01000025_gene2624 0.0 917.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3XZCX@572511|Blautia 186801|Clostridia T Psort location - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_00310 33035.JPJF01000025_gene2623 2.33e-170 474.0 COG0692@1|root,COG0692@2|Bacteria,1TPSN@1239|Firmicutes,247N9@186801|Clostridia,3XYSN@572511|Blautia 186801|Clostridia L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG KKPNOBBG_00311 33035.JPJF01000025_gene2622 0.0 955.0 COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,3XZ3N@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 spoVB1 - - ko:K06409 - - - - ko00000,ko02000 2.A.66.2.14 - - Polysacc_synt,Polysacc_synt_C KKPNOBBG_00312 33035.JPJF01000025_gene2621 0.0 2755.0 COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,3XYXK@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 hgdC2 - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D KKPNOBBG_00313 33035.JPJF01000025_gene2620 7.17e-281 766.0 COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,3XZ2I@572511|Blautia 186801|Clostridia F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT KKPNOBBG_00314 33035.JPJF01000025_gene2619 2.33e-68 207.0 COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,3Y0GK@572511|Blautia 186801|Clostridia U COG COG1862 Preprotein translocase subunit YajC yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC KKPNOBBG_00315 33035.JPJF01000025_gene2618 5.41e-150 422.0 COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia,3XZ6R@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 sdaAB - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - ACT,SDH_beta KKPNOBBG_00316 33035.JPJF01000025_gene2617 1.34e-182 511.0 COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,3XYU6@572511|Blautia 186801|Clostridia E L-serine dehydratase, iron-sulfur-dependent, alpha subunit sdaAA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha KKPNOBBG_00317 33035.JPJF01000025_gene2616 5.58e-194 538.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1V8XZ@1239|Firmicutes,24DFZ@186801|Clostridia 186801|Clostridia K Bacterial transcription activator, effector binding domain - - - ko:K13653 - - - - ko00000,ko03000 - - - GyrI-like,HTH_18 KKPNOBBG_00318 33035.JPJF01000025_gene2615 0.0 1179.0 COG0493@1|root,COG1894@1|root,COG0493@2|Bacteria,COG1894@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3XZ32@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 sfrB - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2 KKPNOBBG_00319 33035.JPJF01000025_gene2614 0.0 1138.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,3XYQE@572511|Blautia 186801|Clostridia C NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) hydC - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3 KKPNOBBG_00320 33035.JPJF01000025_gene2613 7.51e-23 87.8 2CJ2I@1|root,33JSU@2|Bacteria,1VPQS@1239|Firmicutes,24VAW@186801|Clostridia,3Y277@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00322 33035.JPJF01000080_gene222 8.93e-250 686.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,3XZ5D@572511|Blautia 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh KKPNOBBG_00323 33035.JPJF01000080_gene221 0.0 1077.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,3XYR1@572511|Blautia 186801|Clostridia H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD KKPNOBBG_00324 33035.JPJF01000080_gene220 0.0 1056.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3XYQS@572511|Blautia 186801|Clostridia H acetolactate synthase large subunit ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N KKPNOBBG_00325 33035.JPJF01000080_gene219 6.85e-254 697.0 COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,247SM@186801|Clostridia,3XZDW@572511|Blautia 186801|Clostridia E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 KKPNOBBG_00326 33035.JPJF01000080_gene218 9.79e-279 762.0 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3XYS5@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 pdxB - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_00328 33035.JPJF01000080_gene217 8.62e-292 797.0 COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,3XZ64@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 KKPNOBBG_00329 33035.JPJF01000080_gene216 5.04e-236 651.0 COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia,3XZNK@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 hydE - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM KKPNOBBG_00330 33035.JPJF01000080_gene215 0.0 936.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,3XYRP@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 hydG - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM KKPNOBBG_00331 33035.JPJF01000080_gene214 7.55e-266 730.0 COG0486@1|root,COG0486@2|Bacteria,1TQA8@1239|Firmicutes,247M4@186801|Clostridia,3XZ1Y@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 hydF - - - - - - - - - - - MMR_HSR1 KKPNOBBG_00332 33035.JPJF01000080_gene213 5.74e-96 281.0 COG0454@1|root,COG0456@2|Bacteria,1V6D6@1239|Firmicutes,24KC1@186801|Clostridia 186801|Clostridia K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_00333 33035.JPJF01000080_gene212 1.42e-232 643.0 COG1524@1|root,COG1524@2|Bacteria,1UZDM@1239|Firmicutes,24DP2@186801|Clostridia 186801|Clostridia S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest KKPNOBBG_00334 33035.JPJF01000080_gene211 0.0 1132.0 COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,3XYQE@572511|Blautia 186801|Clostridia C NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) - - 1.12.1.3,1.6.5.3 ko:K00336,ko:K18332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,NADH-G_4Fe-4S_3 KKPNOBBG_00335 33035.JPJF01000080_gene210 0.0 1216.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3XZ6P@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB KKPNOBBG_00336 33035.JPJF01000080_gene209 5.64e-112 321.0 COG1905@1|root,COG1905@2|Bacteria,1V4IR@1239|Firmicutes,25CD0@186801|Clostridia,3XZET@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx KKPNOBBG_00337 642492.Clole_4203 5.55e-48 162.0 COG1309@1|root,COG1309@2|Bacteria,1V1ZJ@1239|Firmicutes,24FQ3@186801|Clostridia 186801|Clostridia K Transcriptional regulator, tetr family - - - - - - - - - - - - TetR_N KKPNOBBG_00338 658086.HMPREF0994_06099 4.32e-51 168.0 COG0716@1|root,COG0716@2|Bacteria,1VFBC@1239|Firmicutes,25EGI@186801|Clostridia,27MDV@186928|unclassified Lachnospiraceae 186801|Clostridia C Flavodoxin domain - - - - - - - - - - - - Flavodoxin_5 KKPNOBBG_00339 768710.DesyoDRAFT_3743 7.06e-26 103.0 COG1846@1|root,COG1846@2|Bacteria,1VBPQ@1239|Firmicutes,25CVG@186801|Clostridia,265Y7@186807|Peptococcaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 KKPNOBBG_00340 33035.JPJF01000080_gene206 0.0 947.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3XZR0@572511|Blautia 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH KKPNOBBG_00341 33035.JPJF01000080_gene205 0.0 1573.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3XZ76@572511|Blautia 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 KKPNOBBG_00342 33035.JPJF01000080_gene204 4.78e-194 540.0 COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia,3XZH9@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix KKPNOBBG_00343 33035.JPJF01000080_gene203 4.75e-96 287.0 2DPSA@1|root,33365@2|Bacteria,1TTQC@1239|Firmicutes,258MF@186801|Clostridia,3Y0SE@572511|Blautia 186801|Clostridia S Sporulation and spore germination - - - - - - - - - - - - Germane KKPNOBBG_00344 33035.JPJF01000080_gene202 4.83e-238 656.0 COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ6J@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_00345 33035.JPJF01000080_gene201 9.82e-118 337.0 COG0716@1|root,COG0716@2|Bacteria,1V7GG@1239|Firmicutes,24JSD@186801|Clostridia,3Y0FG@572511|Blautia 186801|Clostridia C Flavodoxin domain - - - - - - - - - - - - Flavodoxin_3 KKPNOBBG_00346 33035.JPJF01000080_gene200 3.77e-88 259.0 COG4416@1|root,COG4416@2|Bacteria,1VEMD@1239|Firmicutes,24MRR@186801|Clostridia,3Y0F5@572511|Blautia 186801|Clostridia S COG NOG18757 non supervised orthologous group - - - - - - - - - - - - - KKPNOBBG_00348 33035.JPJF01000080_gene199 3.93e-251 691.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XZ16@572511|Blautia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 KKPNOBBG_00349 33035.JPJF01000080_gene198 1.37e-188 525.0 COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,24F3Z@186801|Clostridia,3XZMZ@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 KKPNOBBG_00350 33035.JPJF01000080_gene197 4.74e-175 489.0 COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia,3XZ3R@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - iHN637.CLJU_RS10670 BPD_transp_1 KKPNOBBG_00351 33035.JPJF01000080_gene196 9.64e-237 652.0 COG0687@1|root,COG0687@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,3XZJT@572511|Blautia 186801|Clostridia P Bacterial extracellular solute-binding protein potD - - ko:K11069,ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 KKPNOBBG_00352 33035.JPJF01000080_gene195 1.25e-129 369.0 COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia,3XZZD@572511|Blautia 186801|Clostridia S PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD KKPNOBBG_00353 33035.JPJF01000080_gene194 2.16e-149 426.0 2DMDS@1|root,32QT4@2|Bacteria,1VGZP@1239|Firmicutes,25EAH@186801|Clostridia,3Y07F@572511|Blautia 186801|Clostridia S Leucine rich repeats (6 copies) - - - - - - - - - - - - LRR_5 KKPNOBBG_00354 33035.JPJF01000080_gene193 1.54e-305 835.0 COG3864@1|root,COG3864@2|Bacteria,1TSI1@1239|Firmicutes,248YT@186801|Clostridia,3XZNV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF2201,DUF2201_N KKPNOBBG_00355 33035.JPJF01000080_gene192 0.0 906.0 COG0714@1|root,COG0714@2|Bacteria,1U8NZ@1239|Firmicutes,248X1@186801|Clostridia,3XZAA@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA,AAA_5 KKPNOBBG_00356 33035.JPJF01000080_gene191 3.11e-155 437.0 COG3279@1|root,COG3279@2|Bacteria,1V1GQ@1239|Firmicutes,24H3F@186801|Clostridia,3Y04V@572511|Blautia 186801|Clostridia T LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg KKPNOBBG_00357 33035.JPJF01000080_gene190 1.95e-231 646.0 COG3290@1|root,COG3290@2|Bacteria,1V225@1239|Firmicutes,24DB7@186801|Clostridia,3Y09H@572511|Blautia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_00358 33035.JPJF01000080_gene189 2.63e-79 237.0 2E9W7@1|root,3341X@2|Bacteria,1VG1X@1239|Firmicutes,24RT9@186801|Clostridia,3Y1UX@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF3887) - - - - - - - - - - - - DUF3887 KKPNOBBG_00359 33035.JPJF01000080_gene188 9.48e-303 824.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,3XYNP@572511|Blautia 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_00360 33035.JPJF01000080_gene187 1.37e-56 185.0 COG0790@1|root,COG0790@2|Bacteria,1TS5X@1239|Firmicutes,258E6@186801|Clostridia,3Y0MX@572511|Blautia 186801|Clostridia S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 KKPNOBBG_00361 33035.JPJF01000080_gene186 8.97e-170 474.0 COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,2489I@186801|Clostridia,3XZQE@572511|Blautia 186801|Clostridia O Psort location CytoplasmicMembrane, score 9.49 - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran KKPNOBBG_00362 33035.JPJF01000080_gene185 2.07e-209 580.0 COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia,3XYP6@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 - - - ko:K07033 - - - - ko00000 - - - UPF0051 KKPNOBBG_00363 33035.JPJF01000080_gene184 3.94e-222 612.0 COG0441@1|root,COG0441@2|Bacteria,1TPW5@1239|Firmicutes,24B69@186801|Clostridia,3Y1G4@572511|Blautia 186801|Clostridia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) - - - - - - - - - - - - - KKPNOBBG_00364 33035.JPJF01000080_gene183 2.56e-212 590.0 COG0330@1|root,COG0330@2|Bacteria,1TRN5@1239|Firmicutes,248UU@186801|Clostridia,3XYMI@572511|Blautia 186801|Clostridia O prohibitin homologues - - - - - - - - - - - - Band_7 KKPNOBBG_00365 33035.JPJF01000080_gene182 2.4e-33 115.0 COG4877@1|root,COG4877@2|Bacteria,1VEY1@1239|Firmicutes,24MV0@186801|Clostridia,3Y0PD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - ParD_like,RHH_5 KKPNOBBG_00366 33035.JPJF01000080_gene181 2.2e-159 450.0 COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,3XZ84@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score ssuC_2 - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 KKPNOBBG_00367 33035.JPJF01000080_gene180 1.55e-175 490.0 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,3XZ5T@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score ssuB_2 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran KKPNOBBG_00368 33035.JPJF01000080_gene179 1.62e-231 638.0 COG1052@1|root,COG1052@2|Bacteria,1TSZ6@1239|Firmicutes,249PP@186801|Clostridia,3XZ54@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 ldhA - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,PTS-HPr KKPNOBBG_00369 33035.JPJF01000080_gene178 3.25e-135 384.0 COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,248EA@186801|Clostridia,3XYMA@572511|Blautia 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queH - 1.17.99.6 ko:K09765 - - - - ko00000,ko01000,ko03016 - - - DUF208 KKPNOBBG_00370 33035.JPJF01000080_gene177 0.0 894.0 COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,3XYGK@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 KKPNOBBG_00371 33035.JPJF01000080_gene176 1.74e-267 733.0 COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3XZ7K@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC KKPNOBBG_00372 33035.JPJF01000080_gene175 0.0 1255.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,3XYKF@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 traI - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt KKPNOBBG_00373 33035.JPJF01000080_gene174 1.31e-126 363.0 COG1207@1|root,COG1207@2|Bacteria,1UH92@1239|Firmicutes,25PYU@186801|Clostridia,3XYPK@572511|Blautia 186801|Clostridia M UDP-N-acetylglucosamine diphosphorylase - - - - - - - - - - - - Hexapep KKPNOBBG_00374 397287.C807_02125 6.59e-72 219.0 COG0454@1|root,COG0456@2|Bacteria,1V3VH@1239|Firmicutes,24IGR@186801|Clostridia,27MXF@186928|unclassified Lachnospiraceae 186801|Clostridia K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_00375 33035.JPJF01000080_gene173 1.42e-122 352.0 COG1988@1|root,COG1988@2|Bacteria,1V742@1239|Firmicutes,24KF4@186801|Clostridia 186801|Clostridia S Membrane-bound metal-dependent hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM KKPNOBBG_00376 33035.JPJF01000080_gene172 1.17e-152 432.0 2AYHW@1|root,31QMC@2|Bacteria,1V6S7@1239|Firmicutes,24NBV@186801|Clostridia,3Y013@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - TraX KKPNOBBG_00378 476272.RUMHYD_02988 2.42e-47 171.0 2E2H9@1|root,32XM9@2|Bacteria,1VC5F@1239|Firmicutes,259ZF@186801|Clostridia,3XZVR@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF5067) - - - - - - - - - - - - DUF5067 KKPNOBBG_00379 33035.JPJF01000080_gene171 1.26e-272 749.0 COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,3Y0H4@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - 2.4.1.337 ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00380 33035.JPJF01000080_gene170 1.14e-252 694.0 COG0438@1|root,COG0438@2|Bacteria,1TPSS@1239|Firmicutes,249NS@186801|Clostridia,3Y0WU@572511|Blautia 186801|Clostridia M Glycosyl transferases group 1 - - - ko:K13678 - - R10865 RC00005,RC00049 ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00381 33035.JPJF01000080_gene169 9.83e-127 362.0 COG0398@1|root,COG0398@2|Bacteria,1V7NH@1239|Firmicutes,24HNU@186801|Clostridia,3Y1EU@572511|Blautia 186801|Clostridia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc KKPNOBBG_00382 33035.JPJF01000080_gene168 0.0 1077.0 COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25KD8@186801|Clostridia,3XYQ4@572511|Blautia 186801|Clostridia C PAS domain - - - - - - - - - - - - FeS,Fe_hyd_lg_C,Fer4,PAS KKPNOBBG_00383 33035.JPJF01000080_gene167 9.99e-269 737.0 COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes,248FZ@186801|Clostridia,3XZWJ@572511|Blautia 186801|Clostridia KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - SpoIIE KKPNOBBG_00384 33035.JPJF01000080_gene166 8.01e-112 321.0 COG1905@1|root,COG1905@2|Bacteria,1V4IR@1239|Firmicutes,25CD0@186801|Clostridia,3XZET@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx KKPNOBBG_00385 33035.JPJF01000080_gene165 0.0 1228.0 COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3XZ6P@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB KKPNOBBG_00386 33035.JPJF01000080_gene164 0.0 1827.0 COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,3XYRD@572511|Blautia 186801|Clostridia C Molydopterin dinucleotide binding domain fdhA2 - 1.17.1.11,1.17.1.9 ko:K00123,ko:K22341 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 KKPNOBBG_00387 33035.JPJF01000080_gene163 1.43e-274 753.0 COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,3Y0HF@572511|Blautia 186801|Clostridia H MoeA N-terminal region (domain I and II) moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N KKPNOBBG_00388 33035.JPJF01000080_gene162 3.07e-266 734.0 COG0746@1|root,COG1524@1|root,COG0746@2|Bacteria,COG1524@2|Bacteria,1UQ1Y@1239|Firmicutes,257PR@186801|Clostridia,3Y0VI@572511|Blautia 186801|Clostridia H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor - - - - - - - - - - - - NTP_transf_3 KKPNOBBG_00390 33035.JPJF01000080_gene160 4.2e-247 681.0 COG1618@1|root,COG1763@1|root,COG1618@2|Bacteria,COG1763@2|Bacteria,1VGU5@1239|Firmicutes,24QRA@186801|Clostridia,3Y0TU@572511|Blautia 186801|Clostridia F NTPase - - 3.6.1.15 ko:K06928 ko00230,ko00730,ko01100,map00230,map00730,map01100 - R00086,R00615 RC00002 ko00000,ko00001,ko01000 - - - NTPase_1 KKPNOBBG_00391 33035.JPJF01000080_gene159 0.0 2854.0 COG4733@1|root,COG4733@2|Bacteria,1URCK@1239|Firmicutes,24CZ8@186801|Clostridia 186801|Clostridia M domain protein - - - - - - - - - - - - F5_F8_type_C,Peptidase_M60,fn3 KKPNOBBG_00392 33035.JPJF01000080_gene158 3.45e-196 563.0 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein tonB5 - 2.7.11.1 ko:K03466,ko:K08884 - - - - ko00000,ko01000,ko01001,ko03036 3.A.12 - - Pkinase KKPNOBBG_00393 33035.JPJF01000080_gene157 3.19e-74 223.0 COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,3Y08N@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_00394 33035.JPJF01000080_gene156 4.89e-183 511.0 COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,3XYSB@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00395 33035.JPJF01000080_gene155 5.02e-85 256.0 2EI6Y@1|root,33BYA@2|Bacteria,1VNP8@1239|Firmicutes,24URC@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_5 KKPNOBBG_00396 33035.JPJF01000080_gene154 5.22e-173 483.0 COG0846@1|root,COG0846@2|Bacteria,1V41R@1239|Firmicutes,24I6F@186801|Clostridia,3Y1ED@572511|Blautia 186801|Clostridia K Sir2 family - - - - - - - - - - - - SIR2 KKPNOBBG_00397 931276.Cspa_c34240 4.41e-60 189.0 COG0454@1|root,COG0456@2|Bacteria,1V8H2@1239|Firmicutes,24GWJ@186801|Clostridia,36IAQ@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 KKPNOBBG_00398 33035.JPJF01000080_gene153 2.41e-235 648.0 2C4R5@1|root,2Z7JK@2|Bacteria,1TQIE@1239|Firmicutes,24879@186801|Clostridia,3XZAX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - GGGtGRT KKPNOBBG_00399 537007.BLAHAN_05726 1.28e-161 452.0 COG0822@1|root,COG0822@2|Bacteria,1TQEQ@1239|Firmicutes,248ID@186801|Clostridia,3XYM6@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - NifU_N KKPNOBBG_00400 180332.JTGN01000007_gene3513 8.94e-125 403.0 COG0845@1|root,COG4733@1|root,COG0845@2|Bacteria,COG4733@2|Bacteria,1TT2M@1239|Firmicutes,24BJV@186801|Clostridia 186801|Clostridia M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_00401 180332.JTGN01000007_gene3514 1.33e-112 328.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia 186801|Clostridia V ABC transporter macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00402 1123075.AUDP01000003_gene523 1.16e-162 469.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3WGNK@541000|Ruminococcaceae 186801|Clostridia V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_00403 33035.JPJF01000080_gene151 1.52e-87 258.0 COG1846@1|root,COG1846@2|Bacteria,1VDF4@1239|Firmicutes,24NPM@186801|Clostridia 186801|Clostridia K Winged helix DNA-binding domain - - - - - - - - - - - - MarR KKPNOBBG_00404 33035.JPJF01000080_gene150 3.55e-283 778.0 COG0534@1|root,COG0534@2|Bacteria,1TPPJ@1239|Firmicutes,25AZE@186801|Clostridia,3Y02A@572511|Blautia 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_00405 33035.JPJF01000080_gene149 5.57e-118 341.0 2E5I1@1|root,3309D@2|Bacteria,1VG10@1239|Firmicutes,24NJJ@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - YhhN KKPNOBBG_00406 33035.JPJF01000080_gene148 2.32e-234 650.0 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3XYZZ@572511|Blautia 186801|Clostridia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer KKPNOBBG_00407 33035.JPJF01000080_gene147 0.0 879.0 COG1653@1|root,COG1653@2|Bacteria,1TRST@1239|Firmicutes,24APZ@186801|Clostridia 186801|Clostridia G COG COG1653 ABC-type sugar transport system, periplasmic component - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_00408 33035.JPJF01000080_gene146 0.0 2225.0 COG0642@1|root,COG2199@1|root,COG0642@2|Bacteria,COG2199@2|Bacteria,1TS5J@1239|Firmicutes,25EAF@186801|Clostridia 186801|Clostridia T Diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - AAA_16,GAF,GGDEF,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase,Response_reg,SBP_bac_3,dCache_1 KKPNOBBG_00409 33035.JPJF01000080_gene145 9.42e-95 276.0 COG2703@1|root,COG2703@2|Bacteria,1VAI0@1239|Firmicutes,24MQU@186801|Clostridia,3XZZH@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 - - - ko:K07216 - - - - ko00000 - - - Hemerythrin KKPNOBBG_00410 33035.JPJF01000080_gene144 2.37e-76 226.0 COG2158@1|root,COG2158@2|Bacteria,1VFNA@1239|Firmicutes,24MYB@186801|Clostridia,3Y0C2@572511|Blautia 186801|Clostridia S Cysteine-rich small domain - - - ko:K07162 - - - - ko00000 - - - zf-like KKPNOBBG_00411 33035.JPJF01000080_gene143 3.21e-143 405.0 COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia,3Y1GD@572511|Blautia 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2,Mannitol_dh_C KKPNOBBG_00412 33035.JPJF01000080_gene142 2.54e-144 410.0 COG3022@1|root,COG3022@2|Bacteria,1TR33@1239|Firmicutes,248N1@186801|Clostridia,3XZWC@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD KKPNOBBG_00413 33035.JPJF01000080_gene141 8.38e-313 853.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZ7G@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_00414 33035.JPJF01000080_gene140 1.46e-127 366.0 COG0546@1|root,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia,3XZY6@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 nt5e - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_00415 33035.JPJF01000080_gene139 8.17e-116 333.0 COG1878@1|root,COG1878@2|Bacteria,1VDFH@1239|Firmicutes,25CZC@186801|Clostridia 186801|Clostridia S Putative cyclase - - 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase KKPNOBBG_00416 33035.JPJF01000080_gene138 4.75e-199 554.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,3XZ7M@572511|Blautia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_00417 33035.JPJF01000080_gene137 0.0 2069.0 COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,24819@186801|Clostridia,3XZCA@572511|Blautia 186801|Clostridia F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB2 - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS KKPNOBBG_00418 33035.JPJF01000080_gene136 3.41e-233 643.0 COG3081@1|root,COG3081@2|Bacteria,1TSR5@1239|Firmicutes,25CG3@186801|Clostridia,3Y16K@572511|Blautia 186801|Clostridia S 37-kD nucleoid-associated bacterial protein - - - - - - - - - - - - NA37 KKPNOBBG_00419 33035.JPJF01000080_gene135 3.84e-315 860.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3XYY1@572511|Blautia 186801|Clostridia P COG COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF KKPNOBBG_00420 33035.JPJF01000080_gene134 7.66e-70 211.0 COG2198@1|root,COG2198@2|Bacteria,1TUB6@1239|Firmicutes,257TB@186801|Clostridia,3Y0UT@572511|Blautia 186801|Clostridia T Histidine Phosphotransfer domain - - - - - - - - - - - - Hpt KKPNOBBG_00421 33035.JPJF01000080_gene133 3.26e-160 449.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,3XZ3X@572511|Blautia 186801|Clostridia F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase KKPNOBBG_00422 33035.JPJF01000080_gene132 1.94e-118 340.0 COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,3XZAV@572511|Blautia 186801|Clostridia J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF KKPNOBBG_00423 33035.JPJF01000080_gene131 1.61e-162 455.0 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,3XYZ5@572511|Blautia 186801|Clostridia H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf KKPNOBBG_00424 33035.JPJF01000080_gene130 2.71e-171 480.0 COG0575@1|root,COG0575@2|Bacteria,1UPNB@1239|Firmicutes,248BP@186801|Clostridia,3XZGP@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score 10.00 cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 KKPNOBBG_00425 33035.JPJF01000080_gene129 3.17e-260 714.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,3XYJF@572511|Blautia 186801|Clostridia H Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06420 DXPR_C,DXP_redisom_C,DXP_reductoisom KKPNOBBG_00426 33035.JPJF01000080_gene128 5.95e-280 768.0 COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,3XYIX@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 KKPNOBBG_00427 33035.JPJF01000080_gene127 9.91e-303 825.0 COG3409@1|root,COG3409@2|Bacteria,1TS29@1239|Firmicutes,247SQ@186801|Clostridia,3XZDX@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 sleC - - - - - - - - - - - PG_binding_1,SpoIID KKPNOBBG_00429 33035.JPJF01000080_gene125 0.0 1238.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,3Y0Y4@572511|Blautia 186801|Clostridia U Protein export membrane protein secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF KKPNOBBG_00430 33035.JPJF01000080_gene124 0.0 1215.0 COG3158@1|root,COG3158@2|Bacteria,1TRUQ@1239|Firmicutes,24CIX@186801|Clostridia 186801|Clostridia P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans KKPNOBBG_00431 33035.JPJF01000080_gene123 4.78e-39 130.0 COG1396@1|root,COG1396@2|Bacteria,1VEPX@1239|Firmicutes,24R13@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_00432 33035.JPJF01000080_gene122 3.31e-171 476.0 COG3822@1|root,COG3822@2|Bacteria,1UXBF@1239|Firmicutes,249XW@186801|Clostridia,3Y111@572511|Blautia 186801|Clostridia S Pfam:DUF1498 - - 5.3.1.15 ko:K09988 ko00040,map00040 - R01898 RC00516 ko00000,ko00001,ko01000 - - - Lyx_isomer KKPNOBBG_00433 33035.JPJF01000080_gene121 0.0 999.0 COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,3XZ0V@572511|Blautia 186801|Clostridia H Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N KKPNOBBG_00434 33035.JPJF01000080_gene119 3.62e-216 599.0 COG2017@1|root,COG2017@2|Bacteria,1TS8H@1239|Firmicutes,25JTW@186801|Clostridia,3Y1UN@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF4432) - - - - - - - - - - - - DUF4432 KKPNOBBG_00435 33035.JPJF01000082_gene5162 3.47e-192 537.0 COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia,3XYZC@572511|Blautia 186801|Clostridia Q Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Amidohydro_1 KKPNOBBG_00441 33035.JPJF01000013_gene4580 1.29e-122 358.0 COG2207@1|root,COG2207@2|Bacteria,1UUUM@1239|Firmicutes,25KCJ@186801|Clostridia,3Y1WS@572511|Blautia 2|Bacteria K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_00442 33035.JPJF01000013_gene4581 3.92e-251 695.0 28MXM@1|root,2Z899@2|Bacteria,1TNYK@1239|Firmicutes,24D2N@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00443 556261.HMPREF0240_01729 1.09e-114 350.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,36F95@31979|Clostridiaceae 186801|Clostridia G solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_00444 1232453.BAIF02000086_gene319 2.02e-136 395.0 COG1175@1|root,COG1175@2|Bacteria,1TT3G@1239|Firmicutes,24D1V@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_00445 556261.HMPREF0240_01731 1.28e-124 362.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,36FNN@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02026,ko:K10242 ko02010,map02010 M00206,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.23 - - BPD_transp_1 KKPNOBBG_00446 180332.JTGN01000023_gene1656 6.82e-66 229.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1VR4Z@1239|Firmicutes,24C19@186801|Clostridia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_00447 556261.HMPREF0240_01734 2.4e-126 390.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,248RT@186801|Clostridia,36G92@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_00448 33035.JPJF01000082_gene5164 2.69e-191 531.0 COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,3XZMX@572511|Blautia 186801|Clostridia L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 KKPNOBBG_00449 33035.JPJF01000082_gene5165 1.99e-238 655.0 COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,3XYN7@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc KKPNOBBG_00450 33035.JPJF01000082_gene5166 0.0 1103.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3XYMV@572511|Blautia 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 KKPNOBBG_00451 33035.JPJF01000082_gene5167 1.37e-252 695.0 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3XZ4I@572511|Blautia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 KKPNOBBG_00452 33035.JPJF01000082_gene5168 4.61e-136 389.0 COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,3XZUP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 trmK - 2.1.1.217 ko:K06967 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_18,TrmK KKPNOBBG_00453 33035.JPJF01000082_gene5169 3.58e-167 469.0 COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,3XYVV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - NIF3 KKPNOBBG_00454 33035.JPJF01000082_gene5170 0.0 1087.0 COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,3XYSM@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK KKPNOBBG_00455 33035.JPJF01000077_gene25 1.41e-303 828.0 COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia,3XZFR@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06923 - - - - ko00000 - - - DUF815 KKPNOBBG_00456 33035.JPJF01000077_gene26 5.32e-244 673.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,3XYHH@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score pheA - 4.2.1.51,5.4.99.5 ko:K04518,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT KKPNOBBG_00457 1256908.HMPREF0373_00976 9.66e-148 420.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,25V99@186806|Eubacteriaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00458 1256908.HMPREF0373_00977 0.0 910.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,25V5H@186806|Eubacteriaceae 186801|Clostridia V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_00459 1256908.HMPREF0373_00978 1.68e-117 341.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,25V3T@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00460 1256908.HMPREF0373_00979 5.49e-155 445.0 COG5002@1|root,COG5002@2|Bacteria,1UI6U@1239|Firmicutes,25H6P@186801|Clostridia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_00461 33035.JPJF01000077_gene27 2.39e-94 274.0 COG4905@1|root,COG4905@2|Bacteria,1VAQJ@1239|Firmicutes,24K5I@186801|Clostridia,3Y0E6@572511|Blautia 186801|Clostridia S Putative ABC-transporter type IV - - - - - - - - - - - - ABC_trans_CmpB KKPNOBBG_00462 33035.JPJF01000077_gene28 1.26e-210 583.0 COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,3XZCV@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 9.98 pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N,PyrI_C KKPNOBBG_00463 33035.JPJF01000077_gene29 3.12e-100 290.0 COG1781@1|root,COG1781@2|Bacteria,1V6U9@1239|Firmicutes,24JJU@186801|Clostridia,3XZVS@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C KKPNOBBG_00464 33035.JPJF01000077_gene30 4.72e-213 589.0 COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia,3Y2A5@572511|Blautia 186801|Clostridia H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C KKPNOBBG_00465 33035.JPJF01000077_gene33 1.03e-300 823.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3XYPM@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00467 33035.JPJF01000077_gene34 1.2e-92 275.0 COG1309@1|root,COG1309@2|Bacteria,1V7CM@1239|Firmicutes,24K3K@186801|Clostridia,3Y0PF@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_00468 33035.JPJF01000077_gene35 4.25e-83 247.0 2C5N5@1|root,32Y15@2|Bacteria,1VEIC@1239|Firmicutes,24I2X@186801|Clostridia,3Y0C0@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_00469 33035.JPJF01000077_gene36 6.11e-301 826.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XZ7Q@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00470 33035.JPJF01000077_gene37 4.89e-189 528.0 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia,3Y193@572511|Blautia 186801|Clostridia EG Triose-phosphate Transporter family - - - - - - - - - - - - EamA KKPNOBBG_00471 33035.JPJF01000077_gene38 3.75e-243 668.0 COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,3XZT8@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 moeA2 - - - - - - - - - - - MoCF_biosynth KKPNOBBG_00472 33035.JPJF01000077_gene39 2.28e-201 560.0 COG1975@1|root,COG1975@2|Bacteria,1UZDB@1239|Firmicutes,25D6N@186801|Clostridia,3XZKY@572511|Blautia 186801|Clostridia O COG COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI KKPNOBBG_00473 33035.JPJF01000077_gene41 2.19e-147 422.0 COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,3Y07V@572511|Blautia 186801|Clostridia P COG COG0725 ABC-type molybdate transport system, periplasmic component modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - iHN637.CLJU_RS12820 SBP_bac_11 KKPNOBBG_00474 33035.JPJF01000077_gene42 1.66e-147 417.0 COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,24BR9@186801|Clostridia,3XZF3@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 KKPNOBBG_00475 33035.JPJF01000077_gene43 1.95e-231 639.0 COG1118@1|root,COG1118@2|Bacteria,1UI1E@1239|Firmicutes,25EAE@186801|Clostridia 186801|Clostridia P ABC transporter modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran KKPNOBBG_00476 33035.JPJF01000077_gene44 3.76e-108 312.0 COG1522@1|root,COG1522@2|Bacteria,1V3PB@1239|Firmicutes,24I3N@186801|Clostridia,3Y05J@572511|Blautia 186801|Clostridia K Lrp/AsnC ligand binding domain yugG - - - - - - - - - - - AsnC_trans_reg,HTH_24 KKPNOBBG_00477 33035.JPJF01000077_gene45 2.08e-265 728.0 COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,3XYJ7@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 aspC - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_00478 33035.JPJF01000077_gene46 1.98e-314 857.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3XYV0@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 thrA - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 KKPNOBBG_00479 33035.JPJF01000077_gene47 7.41e-191 533.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3XYVT@572511|Blautia 186801|Clostridia C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family hprA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_00481 33035.JPJF01000077_gene49 2.84e-83 247.0 COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,24NBX@186801|Clostridia,3Y0GI@572511|Blautia 186801|Clostridia S Thioesterase-like superfamily FcbC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 KKPNOBBG_00482 33035.JPJF01000077_gene50 4.37e-81 240.0 COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,24MTU@186801|Clostridia,3Y09K@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_00483 33035.JPJF01000077_gene51 4.03e-209 578.0 COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia,3XYHB@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score ytrB - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00484 33035.JPJF01000077_gene52 0.0 1088.0 COG1277@1|root,COG1277@2|Bacteria,1TRJ8@1239|Firmicutes,24EMN@186801|Clostridia,3Y097@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - KKPNOBBG_00485 33035.JPJF01000077_gene53 1.22e-216 598.0 COG4189@1|root,COG4189@2|Bacteria,1TPGD@1239|Firmicutes,248UW@186801|Clostridia,3Y1F8@572511|Blautia 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 KKPNOBBG_00486 33035.JPJF01000077_gene54 8.85e-267 732.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3XZEU@572511|Blautia 186801|Clostridia H Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg KKPNOBBG_00487 33035.JPJF01000077_gene55 0.0 983.0 COG4468@1|root,COG4468@2|Bacteria,1TPBN@1239|Firmicutes,247ZN@186801|Clostridia,3XZID@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf KKPNOBBG_00488 33035.JPJF01000077_gene56 1e-100 292.0 COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,3Y071@572511|Blautia 186801|Clostridia I Thioesterase superfamily yciA - - - - - - - - - - - 4HBT KKPNOBBG_00489 33035.JPJF01000077_gene57 0.0 1666.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,3XYYX@572511|Blautia 186801|Clostridia L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 KKPNOBBG_00490 33035.JPJF01000077_gene58 2.37e-137 389.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,3Y05Z@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE KKPNOBBG_00491 33035.JPJF01000077_gene59 2.06e-189 526.0 COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,3XYGN@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yycJ - - - - - - - - - - - Lactamase_B,Lactamase_B_2 KKPNOBBG_00492 33035.JPJF01000077_gene60 1.01e-52 166.0 COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,3Y0FS@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 8.87 - - - ko:K07166 - - - - ko00000 - - - ACT_6 KKPNOBBG_00493 33035.JPJF01000077_gene61 0.0 870.0 COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,3XYI2@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K09157 - - - - ko00000 - - - DUF711 KKPNOBBG_00494 33035.JPJF01000077_gene62 1.71e-34 118.0 COG1918@1|root,COG1918@2|Bacteria,1VEYA@1239|Firmicutes,24QKX@186801|Clostridia,3Y0RP@572511|Blautia 186801|Clostridia P COG COG1918 Fe2 transport system protein A - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA KKPNOBBG_00495 33035.JPJF01000077_gene63 2.13e-44 144.0 COG1918@1|root,COG1918@2|Bacteria,1VEHC@1239|Firmicutes,24QKE@186801|Clostridia,3Y0MM@572511|Blautia 186801|Clostridia P COG COG1918 Fe2 transport system protein A feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA KKPNOBBG_00496 33035.JPJF01000077_gene64 0.0 1356.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3XZAE@572511|Blautia 186801|Clostridia P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate KKPNOBBG_00497 33035.JPJF01000077_gene66 1.31e-203 574.0 COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,3XYI6@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HIGH_NTase1 KKPNOBBG_00498 33035.JPJF01000077_gene67 1.33e-285 781.0 COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,3XZFQ@572511|Blautia 186801|Clostridia H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase KKPNOBBG_00499 33035.JPJF01000077_gene68 1.34e-120 344.0 COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,3Y029@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07040 - - - - ko00000 - - - DUF177 KKPNOBBG_00500 476272.RUMHYD_00262 3.26e-36 122.0 COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,3Y0IR@572511|Blautia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p KKPNOBBG_00501 33035.JPJF01000077_gene69 1.26e-131 380.0 COG3291@1|root,COG5263@1|root,COG3291@2|Bacteria,COG5263@2|Bacteria,1VGIF@1239|Firmicutes,24REI@186801|Clostridia,3Y1NH@572511|Blautia 186801|Clostridia S repeat protein - - - - - - - - - - - - - KKPNOBBG_00502 33035.JPJF01000077_gene70 3.19e-223 617.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,3XYGR@572511|Blautia 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis KKPNOBBG_00503 33035.JPJF01000077_gene71 2.97e-41 136.0 COG0236@1|root,COG0236@2|Bacteria,1UGNP@1239|Firmicutes,25P5Y@186801|Clostridia,3Y0KT@572511|Blautia 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding KKPNOBBG_00504 33035.JPJF01000077_gene72 9.13e-161 451.0 COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,3XZ9W@572511|Blautia 186801|Clostridia J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm KKPNOBBG_00505 33035.JPJF01000077_gene73 0.0 1682.0 COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,3XYK7@572511|Blautia 186801|Clostridia D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge KKPNOBBG_00506 33035.JPJF01000077_gene74 8.75e-210 581.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,3XZT9@572511|Blautia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N KKPNOBBG_00507 33035.JPJF01000077_gene75 5.06e-280 766.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3XYJM@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP KKPNOBBG_00508 33035.JPJF01000077_gene76 2.63e-97 288.0 2EF1U@1|root,338UW@2|Bacteria,1VFI3@1239|Firmicutes,24G8I@186801|Clostridia,3Y0T5@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00509 33035.JPJF01000060_gene2355 8.92e-251 690.0 COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,3XYVJ@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4,Fer4_21,Fer4_6,Fer4_7 KKPNOBBG_00510 33035.JPJF01000060_gene2356 1.94e-237 664.0 COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,3XZGY@572511|Blautia 186801|Clostridia S Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes larC - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 KKPNOBBG_00511 33035.JPJF01000060_gene2357 1.88e-165 466.0 COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,3Y0BE@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06864 - - - - ko00000 - - - ATP_bind_3,Asn_synthase,NAD_synthase,QueC KKPNOBBG_00513 33035.JPJF01000060_gene2358 1.16e-132 378.0 COG1309@1|root,COG1309@2|Bacteria,1VBYY@1239|Firmicutes,24NAP@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - ko:K22106 - - - - ko00000,ko03000 - - - TetR_N KKPNOBBG_00514 33035.JPJF01000060_gene2359 5.2e-297 814.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,3XZU5@572511|Blautia 186801|Clostridia G COG COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_00516 397291.C804_04065 6.5e-65 209.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,27IHK@186928|unclassified Lachnospiraceae 186801|Clostridia LU DNA recombination-mediator protein A - - - - - - - - - - - - DNA_processg_A KKPNOBBG_00517 33035.JPJF01000060_gene2361 7e-71 214.0 COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia,3Y0C3@572511|Blautia 186801|Clostridia S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein - - - ko:K09787 - - - - ko00000 - - - UPF0122 KKPNOBBG_00518 33035.JPJF01000060_gene2362 1.79e-289 794.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,3XZA0@572511|Blautia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB KKPNOBBG_00519 658655.HMPREF0988_01704 1.16e-47 152.0 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,27NX3@186928|unclassified Lachnospiraceae 186801|Clostridia J Ribosomal protein S16 rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 KKPNOBBG_00520 33035.JPJF01000060_gene2364 5.99e-41 135.0 COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3Y0D4@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 ylqC - - ko:K06960 - - - - ko00000 - - - KH_4 KKPNOBBG_00521 33035.JPJF01000060_gene2365 1.2e-111 321.0 COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3Y02M@572511|Blautia 186801|Clostridia J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM KKPNOBBG_00522 33035.JPJF01000060_gene2366 1.35e-315 863.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,3XYT2@572511|Blautia 186801|Clostridia J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT KKPNOBBG_00523 33035.JPJF01000060_gene2368 1.45e-58 182.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_00524 33035.JPJF01000060_gene2369 6.87e-297 813.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,3XYYC@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Bac_transf,CoA_binding_3 KKPNOBBG_00526 411463.EUBVEN_01489 1.19e-213 597.0 COG0438@1|root,COG0438@2|Bacteria,1TR0Y@1239|Firmicutes,24B5E@186801|Clostridia,25ZDW@186806|Eubacteriaceae 186801|Clostridia M Domain of unknown function (DUF1972) - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00527 411463.EUBVEN_01488 1.51e-248 687.0 COG0438@1|root,COG0438@2|Bacteria,1V0JW@1239|Firmicutes,24CKB@186801|Clostridia,25XU5@186806|Eubacteriaceae 186801|Clostridia M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00528 742742.HMPREF9452_00651 1.18e-84 266.0 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups oatA - - ko:K16568 - - - - ko00000 - - - Acyl_transf_3 KKPNOBBG_00529 742740.HMPREF9474_01720 1.76e-268 746.0 COG0438@1|root,COG0535@1|root,COG0438@2|Bacteria,COG0535@2|Bacteria,1UXWS@1239|Firmicutes,247NG@186801|Clostridia,21Y9U@1506553|Lachnoclostridium 186801|Clostridia C Iron-sulfur cluster-binding domain - - - ko:K22227 - - - - ko00000 - - - Fer4_12,Fer4_14,Radical_SAM,SPASM KKPNOBBG_00530 478749.BRYFOR_06591 3.23e-131 381.0 COG0463@1|root,COG0463@2|Bacteria,1V8T1@1239|Firmicutes,24E8C@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_00532 742742.HMPREF9452_00650 2.65e-63 206.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups lpg2 - 2.4.1.337 ko:K00754,ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00533 742742.HMPREF9452_00650 1.57e-22 95.9 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups lpg2 - 2.4.1.337 ko:K00754,ko:K19002 ko00561,ko01100,map00561,map01100 - R10850 RC00005,RC00059 ko00000,ko00001,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00534 742742.HMPREF9452_00649 4.88e-188 527.0 28PSK@1|root,2ZCE3@2|Bacteria,2IBFI@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - KKPNOBBG_00535 742742.HMPREF9452_00648 3.04e-102 299.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity capG - - - - - - - - - - - Hexapep,Hexapep_2 KKPNOBBG_00536 742742.HMPREF9452_00647 2.39e-102 311.0 COG4763@1|root,COG4763@2|Bacteria 2|Bacteria S transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - Acyl_transf_3 KKPNOBBG_00537 742742.HMPREF9452_00646 2.31e-105 317.0 COG3774@1|root,COG3774@2|Bacteria,2ICTC@201174|Actinobacteria 201174|Actinobacteria M Capsular polysaccharide synthesis protein - - - - - - - - - - - - Caps_synth KKPNOBBG_00539 742742.HMPREF9452_00645 1e-123 372.0 2E63C@1|root,330SF@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - KKPNOBBG_00540 742742.HMPREF9452_00644 3.13e-145 430.0 COG2244@1|root,COG2244@2|Bacteria,2I9QU@201174|Actinobacteria 201174|Actinobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C KKPNOBBG_00541 742742.HMPREF9452_00643 9.54e-21 92.8 COG3274@1|root,COG3274@2|Bacteria,2IPK1@201174|Actinobacteria,4CYAY@84998|Coriobacteriia 84998|Coriobacteriia S Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 KKPNOBBG_00543 1392487.JIAD01000001_gene513 1.32e-16 79.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,25VDF@186806|Eubacteriaceae 186801|Clostridia M Phage tail tape measure protein, TP901 family - - - - - - - - - - - - Peptidase_M23,PhageMin_Tail KKPNOBBG_00544 478749.BRYFOR_09694 1.3e-72 243.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia 186801|Clostridia E Phage tail tape measure protein, TP901 family - - - - - - - - - - - - PhageMin_Tail KKPNOBBG_00547 397288.C806_00771 6.54e-08 62.8 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,27J2F@186928|unclassified Lachnospiraceae 186801|Clostridia S Phage-related minor tail protein - - - - - - - - - - - - PhageMin_Tail KKPNOBBG_00549 565664.EFXG_00702 3.13e-24 102.0 COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,4HEYD@91061|Bacilli 91061|Bacilli E Nucleoid-structuring protein H-NS - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like KKPNOBBG_00551 33035.JPJF01000060_gene2391 2.99e-55 173.0 29WCW@1|root,30HYJ@2|Bacteria,1UUVE@1239|Firmicutes,2596R@186801|Clostridia,3Y25S@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00554 33035.JPJF01000060_gene2394 3.75e-127 369.0 29VW1@1|root,30HDW@2|Bacteria,1UHIW@1239|Firmicutes,25QAG@186801|Clostridia,3Y1RQ@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF5011) - - - - - - - - - - - - DUF5011 KKPNOBBG_00555 33035.JPJF01000060_gene2395 6.68e-160 449.0 COG4464@1|root,COG4464@2|Bacteria,1TQ1T@1239|Firmicutes,24JQU@186801|Clostridia,3XZY8@572511|Blautia 186801|Clostridia GM Psort location Cytoplasmic, score 8.87 - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - - KKPNOBBG_00556 33035.JPJF01000060_gene2396 3.31e-144 409.0 COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia,3XZU6@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score - - - - - - - - - - - - AAA_31 KKPNOBBG_00557 33035.JPJF01000060_gene2397 7.24e-164 460.0 COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,3Y0BB@572511|Blautia 186801|Clostridia M Chain length determinant protein - - - - - - - - - - - - GNVR,Wzz KKPNOBBG_00558 33035.JPJF01000060_gene2398 8.08e-143 408.0 COG4509@1|root,COG4509@2|Bacteria,1V4RE@1239|Firmicutes,24JWD@186801|Clostridia,3XZZZ@572511|Blautia 186801|Clostridia S Sortase family - - 3.4.22.70 ko:K08600 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase KKPNOBBG_00559 33035.JPJF01000060_gene2399 7.2e-193 540.0 COG1316@1|root,COG1316@2|Bacteria,1UY3P@1239|Firmicutes,24H37@186801|Clostridia,3Y00F@572511|Blautia 186801|Clostridia K Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_cpsA_psr KKPNOBBG_00560 33035.JPJF01000060_gene2400 8.59e-116 334.0 2AYEN@1|root,31QHP@2|Bacteria,1V7VT@1239|Firmicutes,24JY6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00561 33035.JPJF01000060_gene2401 2.92e-259 709.0 COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,3XZ56@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd KKPNOBBG_00562 33035.JPJF01000060_gene2402 3.31e-264 726.0 COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1TSDZ@1239|Firmicutes,248EY@186801|Clostridia,3Y1FI@572511|Blautia 186801|Clostridia KQ helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1,Methyltransf_11,Methyltransf_25,Methyltransf_31 KKPNOBBG_00563 33035.JPJF01000060_gene2403 1.4e-206 571.0 COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,3XZI0@572511|Blautia 186801|Clostridia M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133,5.1.3.13 ko:K00067,ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777,R06514 RC00182,RC01531 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind KKPNOBBG_00564 33035.JPJF01000060_gene2404 1.26e-208 577.0 COG1209@1|root,COG1209@2|Bacteria,1V301@1239|Firmicutes,247XE@186801|Clostridia,3XZAG@572511|Blautia 186801|Clostridia H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase KKPNOBBG_00565 33035.JPJF01000060_gene2405 8.81e-84 252.0 COG4767@1|root,COG4767@2|Bacteria,1VHCV@1239|Firmicutes,24RMJ@186801|Clostridia,3Y0NZ@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - VanZ KKPNOBBG_00566 33035.JPJF01000060_gene2406 5.73e-75 224.0 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,3Y019@572511|Blautia 186801|Clostridia J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 KKPNOBBG_00567 33035.JPJF01000060_gene2407 2.35e-126 360.0 COG0681@1|root,COG0681@2|Bacteria,1V2SF@1239|Firmicutes,24AWM@186801|Clostridia,3XZTM@572511|Blautia 186801|Clostridia U Signal peptidase, peptidase S26 - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 KKPNOBBG_00568 33035.JPJF01000060_gene2408 1.56e-182 509.0 COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,3XYWP@572511|Blautia 186801|Clostridia S Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity ylqF - - ko:K14540 - - - - ko00000,ko03009 - - - MMR_HSR1 KKPNOBBG_00569 33035.JPJF01000060_gene2409 1.62e-160 452.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,3XZF8@572511|Blautia 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII KKPNOBBG_00570 33035.JPJF01000060_gene2410 1.96e-68 208.0 COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,3Y0HI@572511|Blautia 186801|Clostridia L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 KKPNOBBG_00571 33035.JPJF01000060_gene2411 1.66e-181 508.0 COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,3XYQB@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 KKPNOBBG_00572 33035.JPJF01000060_gene2412 1.57e-146 429.0 COG3584@1|root,COG3883@1|root,COG3584@2|Bacteria,COG3883@2|Bacteria,1UI15@1239|Firmicutes,25EA3@186801|Clostridia,3XZ75@572511|Blautia 186801|Clostridia S Psort location Extracellular, score - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - - KKPNOBBG_00573 33035.JPJF01000060_gene2413 3.7e-279 763.0 COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3XYPC@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N KKPNOBBG_00574 33035.JPJF01000060_gene2414 1.23e-309 846.0 COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,3XYRJ@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF512 KKPNOBBG_00575 33035.JPJF01000060_gene2415 3.6e-296 810.0 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,3XZ3Z@572511|Blautia 186801|Clostridia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 KKPNOBBG_00576 33035.JPJF01000060_gene2416 1.29e-148 418.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,3XZ7V@572511|Blautia 186801|Clostridia I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf KKPNOBBG_00577 33035.JPJF01000060_gene2417 1.95e-225 623.0 COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,3XYNR@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N KKPNOBBG_00578 33035.JPJF01000060_gene2418 1.09e-166 468.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,3XYST@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00579 33035.JPJF01000060_gene2419 7.56e-198 572.0 COG0845@1|root,COG0845@2|Bacteria,1UZA4@1239|Firmicutes,24BV0@186801|Clostridia,3XZ43@572511|Blautia 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_00580 33035.JPJF01000060_gene2420 3.88e-243 674.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3XZ8E@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 macB2 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_00581 33035.JPJF01000060_gene2421 4.49e-195 541.0 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,3XYQK@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yvgN - - - - - - - - - - - Aldo_ket_red KKPNOBBG_00582 33035.JPJF01000060_gene2422 2.3e-227 631.0 COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,3XYWR@572511|Blautia 186801|Clostridia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,SbcD_C KKPNOBBG_00583 33035.JPJF01000060_gene2423 0.0 1270.0 COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,3XZKX@572511|Blautia 186801|Clostridia L Psort location sbcC - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,AAA_29,SbcCD_C KKPNOBBG_00584 33035.JPJF01000060_gene2424 8.54e-67 203.0 2CEVS@1|root,32WBX@2|Bacteria,1VBHQ@1239|Firmicutes,24QCM@186801|Clostridia,3Y0BP@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00585 33035.JPJF01000060_gene2425 2.42e-33 115.0 2FK7C@1|root,34BV3@2|Bacteria,1W6KA@1239|Firmicutes,254TZ@186801|Clostridia,3Y0MF@572511|Blautia 186801|Clostridia S Predicted RNA-binding protein - - - - - - - - - - - - RNA_bind_2 KKPNOBBG_00586 33035.JPJF01000060_gene2426 1.15e-225 620.0 COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,3Y08F@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR KKPNOBBG_00587 33035.JPJF01000060_gene2427 6.85e-179 498.0 COG3640@1|root,COG3640@2|Bacteria,1UZHR@1239|Firmicutes,24BYR@186801|Clostridia,3XYPW@572511|Blautia 186801|Clostridia D cell division inhibitor, membrane ATPase MinD cooC1 - - ko:K07321 - - - - ko00000 - - - AAA_31,CbiA KKPNOBBG_00588 33035.JPJF01000060_gene2428 0.0 1256.0 COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,3XZEI@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 cooS1 - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane KKPNOBBG_00589 33035.JPJF01000060_gene2429 3.14e-179 499.0 COG3640@1|root,COG3640@2|Bacteria,1TPCY@1239|Firmicutes,247JM@186801|Clostridia,3XZK1@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 cooC - - ko:K07321 - - - - ko00000 - - - CbiA KKPNOBBG_00590 537007.BLAHAN_05772 0.0 1327.0 COG1614@1|root,COG1614@2|Bacteria,1TSWZ@1239|Firmicutes,248Y2@186801|Clostridia,3XZDK@572511|Blautia 186801|Clostridia C acetyl-CoA decarbonylase synthase complex subunit beta cdhC - 2.3.1.169 ko:K14138 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R08433,R10243 RC00004,RC00113,RC01144,RC02963,RC02964,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhC KKPNOBBG_00591 33035.JPJF01000038_gene571 1.41e-215 596.0 COG2069@1|root,COG2069@2|Bacteria,1TSSY@1239|Firmicutes,24BVJ@186801|Clostridia,3XZ3W@572511|Blautia 186801|Clostridia C CO dehydrogenase/acetyl-CoA synthase delta subunit acsD - 2.1.1.245 ko:K00194 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD KKPNOBBG_00592 33035.JPJF01000038_gene570 7.96e-296 809.0 COG1456@1|root,COG1456@2|Bacteria,1TPWJ@1239|Firmicutes,24CTU@186801|Clostridia,3XZ0J@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 acsC - 2.1.1.245 ko:K00197 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00357,M00377,M00422 R09096,R10219,R10243 RC00004,RC00113,RC02977 ko00000,ko00001,ko00002,ko01000 - - - CdhD,FeS KKPNOBBG_00593 33035.JPJF01000038_gene569 3.41e-186 517.0 COG1410@1|root,COG1410@2|Bacteria,1UXXG@1239|Firmicutes,24D45@186801|Clostridia,3XZQ5@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 acsE - 2.1.1.258 ko:K15023 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00377 R02289,R10243 RC00004,RC00113,RC01144,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind KKPNOBBG_00594 33035.JPJF01000038_gene568 0.0 1254.0 COG1018@1|root,COG3894@1|root,COG1018@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,3XYV5@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4445,Fer2 KKPNOBBG_00595 33035.JPJF01000038_gene567 7.19e-154 432.0 2C5Z2@1|root,32A20@2|Bacteria,1V5CS@1239|Firmicutes,24M7C@186801|Clostridia,3XZ4M@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 KKPNOBBG_00596 33035.JPJF01000038_gene566 6.37e-126 359.0 COG3275@1|root,COG3275@2|Bacteria,1TTD7@1239|Firmicutes,25MGI@186801|Clostridia,3Y1YW@572511|Blautia 186801|Clostridia T ECF-type riboflavin transporter, S component - - - - - - - - - - - - - KKPNOBBG_00597 33035.JPJF01000038_gene565 2.59e-137 389.0 COG3404@1|root,COG3404@2|Bacteria,1V14R@1239|Firmicutes,24D90@186801|Clostridia,3XYUI@572511|Blautia 186801|Clostridia E Formiminotransferase-cyclodeaminase fchA - - - - - - - - - - - FTCD_C KKPNOBBG_00598 33035.JPJF01000038_gene564 2.15e-200 555.0 COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,3XZ53@572511|Blautia 186801|Clostridia H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C KKPNOBBG_00599 33035.JPJF01000038_gene563 1.56e-312 855.0 COG1502@1|root,COG1502@2|Bacteria,1TSN8@1239|Firmicutes,249G7@186801|Clostridia,3XYPQ@572511|Blautia 186801|Clostridia M COG COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 KKPNOBBG_00600 33035.JPJF01000038_gene562 5.05e-280 772.0 COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia 186801|Clostridia S Extradiol ring-cleavage dioxygenase class III protein subunit B - - - ko:K06990,ko:K09141 - - - - ko00000,ko04812 - - - AMMECR1,LigB KKPNOBBG_00601 33035.JPJF01000038_gene561 3.69e-168 472.0 COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia 186801|Clostridia C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM KKPNOBBG_00602 33035.JPJF01000038_gene560 1.43e-173 484.0 2DBGV@1|root,2Z969@2|Bacteria,1UI0Y@1239|Firmicutes,25E9X@186801|Clostridia,3XZRX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4130 KKPNOBBG_00603 33035.JPJF01000038_gene559 0.0 892.0 COG4277@1|root,COG4277@2|Bacteria,1TRT2@1239|Firmicutes,247UD@186801|Clostridia,3XZAW@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HHH_3,Radical_SAM KKPNOBBG_00604 33035.JPJF01000038_gene558 0.0 944.0 COG0699@1|root,COG0699@2|Bacteria,1TPPG@1239|Firmicutes,24829@186801|Clostridia,3XZK9@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 spoIVA GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008150,GO:0009653,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019954,GO:0030154,GO:0030312,GO:0030435,GO:0030436,GO:0030554,GO:0031160,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0034301,GO:0035639,GO:0036094,GO:0042601,GO:0042763,GO:0043167,GO:0043168,GO:0043934,GO:0043936,GO:0044464,GO:0048646,GO:0048856,GO:0048869,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06398 - - - - ko00000 - - - Spore_IV_A KKPNOBBG_00605 33035.JPJF01000038_gene557 3.25e-254 700.0 COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,248AK@186801|Clostridia,3XYN5@572511|Blautia 186801|Clostridia H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD KKPNOBBG_00606 33035.JPJF01000038_gene556 3.92e-153 431.0 COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,3XYXX@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cobI - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase KKPNOBBG_00607 33035.JPJF01000038_gene555 7.67e-175 488.0 COG2875@1|root,COG2875@2|Bacteria,1TP6J@1239|Firmicutes,248IZ@186801|Clostridia,3XYRB@572511|Blautia 186801|Clostridia H precorrin-4 C11-methyltransferase cobM - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase KKPNOBBG_00608 33035.JPJF01000038_gene554 1.03e-261 717.0 COG2073@1|root,COG2073@2|Bacteria,1TPYM@1239|Firmicutes,247JW@186801|Clostridia,3XZ11@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cbiG - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS15705 CbiG_C,CbiG_N,CbiG_mid KKPNOBBG_00609 33035.JPJF01000038_gene553 1.5e-171 479.0 COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,247QS@186801|Clostridia,3XZR9@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cobJ - 2.1.1.131,2.1.1.272 ko:K05934,ko:K21479 ko00860,ko01100,map00860,map01100 - R05180,R05809,R11580 RC00003,RC01293,RC03471,RC03479 ko00000,ko00001,ko01000 - - - TP_methylase KKPNOBBG_00610 33035.JPJF01000038_gene552 0.0 1175.0 COG2099@1|root,COG2241@1|root,COG2242@1|root,COG2099@2|Bacteria,COG2241@2|Bacteria,COG2242@2|Bacteria,1TS3H@1239|Firmicutes,2483G@186801|Clostridia,3XYK0@572511|Blautia 186801|Clostridia H precorrin-6B methylase decarboxylase cbiT cbiE cbiT - 2.1.1.132,2.1.1.196 ko:K00595,ko:K02191 ko00860,ko01100,map00860,map01100 - R05149,R05813,R07774 RC00003,RC01279,RC02052,RC02054 ko00000,ko00001,ko01000 - - - CbiJ,Cons_hypoth95,MTS,Met_10,Methyltransf_31,Methyltransf_4,PCMT,TP_methylase KKPNOBBG_00611 33035.JPJF01000038_gene551 0.0 877.0 COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,3XYMG@572511|Blautia 186801|Clostridia H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 KKPNOBBG_00612 33035.JPJF01000038_gene550 5.92e-238 655.0 COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,3XYHW@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT - 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT KKPNOBBG_00613 33035.JPJF01000038_gene549 4.36e-116 334.0 COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,3Y004@572511|Blautia 186801|Clostridia H COG COG2087 Adenosyl cobinamide kinase adenosyl cobinamide phosphate guanylyltransferase cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU KKPNOBBG_00614 33035.JPJF01000038_gene548 1.73e-175 490.0 COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,3Y00I@572511|Blautia 186801|Clostridia H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS KKPNOBBG_00615 33035.JPJF01000038_gene547 5.44e-71 215.0 COG2087@1|root,COG2087@2|Bacteria,1VG8S@1239|Firmicutes,24QSM@186801|Clostridia,3Y0HX@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - CobU KKPNOBBG_00616 33035.JPJF01000038_gene546 3.12e-127 363.0 COG0406@1|root,COG0406@2|Bacteria,1V6G1@1239|Firmicutes,24JP4@186801|Clostridia,3XZUY@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 cobC - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 KKPNOBBG_00617 33035.JPJF01000038_gene545 7.97e-207 575.0 COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,247PR@186801|Clostridia,3XZ9X@572511|Blautia 186801|Clostridia H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib KKPNOBBG_00618 33035.JPJF01000038_gene544 3.24e-216 601.0 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,3XYPR@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 cobD_2 - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 KKPNOBBG_00619 33035.JPJF01000038_gene543 0.0 917.0 COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,3XYMB@572511|Blautia 186801|Clostridia H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15780 AAA_26,CbiA,GATase_3 KKPNOBBG_00620 33035.JPJF01000038_gene542 5.22e-145 409.0 COG2082@1|root,COG2082@2|Bacteria,1V1SX@1239|Firmicutes,24B9Z@186801|Clostridia,3XZ03@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cobH - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC KKPNOBBG_00621 33035.JPJF01000038_gene541 4.77e-151 448.0 COG2304@1|root,COG2304@2|Bacteria,1TXAR@1239|Firmicutes,25AE5@186801|Clostridia,3Y1EI@572511|Blautia 186801|Clostridia S oxidoreductase activity - - - - - - - - - - - - - KKPNOBBG_00622 33035.JPJF01000038_gene540 0.0 1055.0 COG1122@1|root,COG4822@1|root,COG1122@2|Bacteria,COG4822@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3XYPV@572511|Blautia 186801|Clostridia P ABC transporter, ATP-binding protein cbiO - - ko:K02006 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - ABC_tran KKPNOBBG_00623 33035.JPJF01000038_gene539 1.12e-169 475.0 COG0619@1|root,COG0619@2|Bacteria,1V0B0@1239|Firmicutes,24A4J@186801|Clostridia,3XYVF@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score cbiQ - - ko:K02008 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiQ KKPNOBBG_00624 33035.JPJF01000038_gene538 1.25e-57 179.0 COG1930@1|root,COG1930@2|Bacteria,1VF03@1239|Firmicutes,24MYG@186801|Clostridia,3Y0GQ@572511|Blautia 186801|Clostridia P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiN - - ko:K02009 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18 - - CbiN KKPNOBBG_00625 33035.JPJF01000038_gene537 3.92e-165 463.0 COG0310@1|root,COG0310@2|Bacteria,1TQVK@1239|Firmicutes,248ZZ@186801|Clostridia,3XYU1@572511|Blautia 186801|Clostridia P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import cbiM - - ko:K02007 ko02010,map02010 M00245,M00246 - - ko00000,ko00001,ko00002,ko02000 3.A.1.18,3.A.1.22,3.A.1.23 - - CbiM KKPNOBBG_00626 33035.JPJF01000038_gene536 1.63e-279 766.0 COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,3XZQJ@572511|Blautia 186801|Clostridia H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,NAD_binding_7,Shikimate_DH KKPNOBBG_00627 33035.JPJF01000038_gene535 8.29e-100 290.0 COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,3Y08Y@572511|Blautia 186801|Clostridia H precorrin-2 oxidase cysG - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M KKPNOBBG_00628 33035.JPJF01000038_gene534 0.0 1481.0 COG0007@1|root,COG0181@1|root,COG1587@1|root,COG0007@2|Bacteria,COG0181@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,3XZE7@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cobA - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase KKPNOBBG_00629 33035.JPJF01000038_gene533 1.82e-230 635.0 COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,3XYXB@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD KKPNOBBG_00630 33035.JPJF01000038_gene532 1.85e-300 820.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,3XZ92@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 KKPNOBBG_00631 33035.JPJF01000038_gene531 0.0 1026.0 COG0249@1|root,COG0249@2|Bacteria,1TPJP@1239|Firmicutes,247IW@186801|Clostridia,3XZ5A@572511|Blautia 186801|Clostridia L DNA mismatch repair protein mutS2 - - - - - - - - - - - MutS_III,MutS_V KKPNOBBG_00632 33035.JPJF01000038_gene530 2.29e-115 330.0 COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,3XZXB@572511|Blautia 186801|Clostridia L RNase H rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H KKPNOBBG_00635 33035.JPJF01000038_gene529 2.5e-305 837.0 COG2211@1|root,COG2211@2|Bacteria,1UJ7Q@1239|Firmicutes,24DJ1@186801|Clostridia 186801|Clostridia G TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_00636 1163671.JAGI01000002_gene3962 3.98e-103 306.0 COG2265@1|root,COG2265@2|Bacteria,1UK4G@1239|Firmicutes,24H6A@186801|Clostridia 186801|Clostridia J Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 KKPNOBBG_00637 33035.JPJF01000038_gene528 1.47e-194 542.0 COG2207@1|root,COG2207@2|Bacteria,1UYFB@1239|Firmicutes,24DAW@186801|Clostridia,3Y28A@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_00638 33035.JPJF01000038_gene527 7.26e-112 325.0 COG2364@1|root,COG2364@2|Bacteria,1TU27@1239|Firmicutes,25NE7@186801|Clostridia,3Y0V8@572511|Blautia 186801|Clostridia S Membrane - - - - - - - - - - - - - KKPNOBBG_00639 33035.JPJF01000038_gene526 0.0 1644.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3XYZ6@572511|Blautia 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD KKPNOBBG_00640 1045858.Bint_0475 4.31e-22 89.4 arCOG10654@1|root,3305G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - KKPNOBBG_00641 865861.AZSU01000001_gene524 1.13e-184 534.0 COG2252@1|root,COG2252@2|Bacteria,1UKEK@1239|Firmicutes,25GW6@186801|Clostridia 186801|Clostridia S PERMEase - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - - KKPNOBBG_00642 1105031.HMPREF1141_2747 6.34e-141 407.0 COG1985@1|root,COG1985@2|Bacteria,1UZJ8@1239|Firmicutes,24DAG@186801|Clostridia,36QHM@31979|Clostridiaceae 186801|Clostridia H RibD C-terminal domain - - - - - - - - - - - - RibD_C KKPNOBBG_00643 1105031.HMPREF1141_2748 1.01e-148 422.0 COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CMB@186801|Clostridia,36HEE@31979|Clostridiaceae 186801|Clostridia G DeoC/LacD family aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC KKPNOBBG_00644 1105031.HMPREF1141_2749 2.99e-178 504.0 COG1063@1|root,COG1063@2|Bacteria,1UZ8R@1239|Firmicutes,248ZT@186801|Clostridia,36H2B@31979|Clostridiaceae 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_00645 1105031.HMPREF1141_2750 5.16e-203 578.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36K78@31979|Clostridiaceae 186801|Clostridia G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_00646 1105031.HMPREF1141_2751 3.06e-129 378.0 COG1985@1|root,COG1985@2|Bacteria,1UZJ8@1239|Firmicutes,24DAG@186801|Clostridia,36R2C@31979|Clostridiaceae 186801|Clostridia H RibD C-terminal domain - - - - - - - - - - - - RibD_C KKPNOBBG_00647 1105031.HMPREF1141_2752 1.54e-210 602.0 COG2252@1|root,COG2252@2|Bacteria,1UKIQ@1239|Firmicutes,25FY4@186801|Clostridia 186801|Clostridia S PERMEase - - - - - - - - - - - - - KKPNOBBG_00648 865861.AZSU01000001_gene530 3.02e-75 231.0 COG0655@1|root,COG0655@2|Bacteria,1V2ZC@1239|Firmicutes,25CAW@186801|Clostridia,36IG3@31979|Clostridiaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red KKPNOBBG_00649 1105031.HMPREF1141_2754 1.01e-72 228.0 COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,36E31@31979|Clostridiaceae 186801|Clostridia K UbiC transcription regulator-associated domain protein - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_00650 33035.JPJF01000038_gene525 0.0 1014.0 COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,3XZ8D@572511|Blautia 186801|Clostridia I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N KKPNOBBG_00651 33035.JPJF01000038_gene524 8.66e-136 384.0 COG4905@1|root,COG4905@2|Bacteria,1V3M8@1239|Firmicutes,24G7Q@186801|Clostridia,3Y1JT@572511|Blautia 186801|Clostridia S Putative ABC-transporter type IV - - - - - - - - - - - - ABC_trans_CmpB KKPNOBBG_00652 33035.JPJF01000038_gene522 2.99e-100 298.0 2DA7D@1|root,32TUU@2|Bacteria,1VEDT@1239|Firmicutes,24REG@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00653 33035.JPJF01000038_gene521 2.64e-267 733.0 COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,3XYIQ@572511|Blautia 186801|Clostridia M Belongs to the peptidase S11 family dacF - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 KKPNOBBG_00654 33035.JPJF01000038_gene520 2.52e-288 791.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XZQ9@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00655 33035.JPJF01000038_gene519 2.64e-161 455.0 COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,3XZYI@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07098 - - - - ko00000 - - - Metallophos KKPNOBBG_00656 33035.JPJF01000038_gene518 1.07e-212 589.0 COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,3XYTD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 9.98 - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 KKPNOBBG_00657 33035.JPJF01000038_gene517 2.35e-251 692.0 COG1721@1|root,COG1721@2|Bacteria,1TSYT@1239|Firmicutes,249GJ@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 KKPNOBBG_00658 33035.JPJF01000038_gene516 6.65e-214 599.0 2DSUF@1|root,33HGC@2|Bacteria,1VK81@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - DUF4129 KKPNOBBG_00659 33035.JPJF01000038_gene515 1e-170 478.0 COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,3XYTH@572511|Blautia 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA KKPNOBBG_00660 33035.JPJF01000038_gene514 1.79e-125 358.0 COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,3XYWQ@572511|Blautia 186801|Clostridia D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB KKPNOBBG_00661 33035.JPJF01000038_gene513 3.12e-178 497.0 COG0770@1|root,COG0770@2|Bacteria,1V1NG@1239|Firmicutes,24GE1@186801|Clostridia,3Y02I@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Zn_dep_PLPC KKPNOBBG_00662 33035.JPJF01000038_gene512 2.08e-284 778.0 COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,24AYI@186801|Clostridia,3XYWK@572511|Blautia 186801|Clostridia S COG COG2270 Permeases of the major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 KKPNOBBG_00663 33035.JPJF01000038_gene511 4.57e-287 785.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3XZ3I@572511|Blautia 186801|Clostridia M Belongs to the peptidase S11 family dacB2 - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 KKPNOBBG_00664 33035.JPJF01000038_gene510 6.92e-110 317.0 COG0778@1|root,COG0778@2|Bacteria,1V4K6@1239|Firmicutes,24B09@186801|Clostridia,3Y0KM@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Nitroreductase KKPNOBBG_00665 33035.JPJF01000038_gene509 1.14e-294 806.0 COG1145@1|root,COG1145@2|Bacteria,1TQG5@1239|Firmicutes,248IV@186801|Clostridia,3Y179@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_6,Fer4_7 KKPNOBBG_00666 33035.JPJF01000038_gene508 1.58e-100 291.0 COG0071@1|root,COG0071@2|Bacteria,1VG0E@1239|Firmicutes,24MRZ@186801|Clostridia,3Y04I@572511|Blautia 186801|Clostridia O COG COG0071 Molecular chaperone (small heat shock protein) hsp18 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 KKPNOBBG_00667 33035.JPJF01000038_gene507 1.17e-156 442.0 COG0010@1|root,COG0010@2|Bacteria,1V6Y2@1239|Firmicutes,24K01@186801|Clostridia,3Y08B@572511|Blautia 186801|Clostridia E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase KKPNOBBG_00668 33035.JPJF01000038_gene506 0.0 4289.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,3Y1GF@572511|Blautia 186801|Clostridia Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyltransferase,Condensation,NAD_binding_4,PP-binding KKPNOBBG_00669 33035.JPJF01000038_gene505 0.0 1079.0 COG4191@1|root,COG4191@2|Bacteria,1UZX4@1239|Firmicutes,24B8M@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,HisKA_7TM,dCache_1 KKPNOBBG_00670 33035.JPJF01000038_gene504 0.0 900.0 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia 186801|Clostridia T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,Response_reg KKPNOBBG_00671 33035.JPJF01000038_gene503 0.0 975.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3XZQH@572511|Blautia 186801|Clostridia I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding KKPNOBBG_00672 33035.JPJF01000038_gene502 7.46e-45 145.0 COG0236@1|root,COG0236@2|Bacteria,1UI0X@1239|Firmicutes,25E9W@186801|Clostridia 186801|Clostridia IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding KKPNOBBG_00673 33035.JPJF01000038_gene501 4.13e-196 545.0 COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,3XZKE@572511|Blautia 186801|Clostridia I COG COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases garR - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 KKPNOBBG_00674 33035.JPJF01000038_gene500 3.15e-64 197.0 2C40S@1|root,2ZJHR@2|Bacteria,1W4S9@1239|Firmicutes,254RW@186801|Clostridia,3Y21T@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00675 33035.JPJF01000038_gene499 9.48e-284 778.0 COG3864@1|root,COG3864@2|Bacteria,1TSI1@1239|Firmicutes,248YT@186801|Clostridia,3XZSG@572511|Blautia 186801|Clostridia S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N KKPNOBBG_00676 33035.JPJF01000038_gene498 2.87e-314 863.0 COG0714@1|root,COG0714@2|Bacteria,1U8NZ@1239|Firmicutes,248X1@186801|Clostridia,3XZAA@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA,AAA_5 KKPNOBBG_00677 33035.JPJF01000038_gene497 1.1e-306 839.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3XZ7T@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp KKPNOBBG_00679 1226325.HMPREF1548_01671 4.76e-46 162.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_00680 411471.SUBVAR_04500 1.26e-52 169.0 COG1321@1|root,COG1321@2|Bacteria,1V4B0@1239|Firmicutes,257TP@186801|Clostridia,3WJQM@541000|Ruminococcaceae 186801|Clostridia K Iron dependent repressor, metal binding and dimerisation domain - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress KKPNOBBG_00681 1035196.HMPREF9998_00561 3.77e-311 853.0 COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,25T6M@186804|Peptostreptococcaceae 186801|Clostridia G ATPases associated with a variety of cellular activities - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,DLIC KKPNOBBG_00682 742740.HMPREF9474_02043 1.02e-153 434.0 COG0619@1|root,COG0619@2|Bacteria,1TTA6@1239|Firmicutes,24GU9@186801|Clostridia,2214X@1506553|Lachnoclostridium 186801|Clostridia P COG COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters - - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ KKPNOBBG_00683 742740.HMPREF9474_02044 9.17e-131 372.0 2BY0N@1|root,2ZBND@2|Bacteria,1TS3Y@1239|Firmicutes,24EZ3@186801|Clostridia,221GW@1506553|Lachnoclostridium 186801|Clostridia S Hypothetical bacterial integral membrane protein (Trep_Strep) - - - ko:K16926 - M00582 - - ko00000,ko00002,ko02000 3.A.1.31 - - Trep_Strep KKPNOBBG_00684 537013.CLOSTMETH_02377 0.0 1026.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247PY@186801|Clostridia,3WHFU@541000|Ruminococcaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_00685 1235798.C817_02716 0.0 1053.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247VZ@186801|Clostridia,27W58@189330|Dorea 186801|Clostridia V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran KKPNOBBG_00686 397290.C810_02565 1.98e-286 787.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,27N18@186928|unclassified Lachnospiraceae 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_00687 658086.HMPREF0994_00438 2.36e-124 356.0 COG1309@1|root,COG1309@2|Bacteria,1TT2J@1239|Firmicutes,24A5X@186801|Clostridia,27KNC@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_00688 1226325.HMPREF1548_01683 1.1e-156 451.0 COG1196@1|root,COG1196@2|Bacteria,1UI9G@1239|Firmicutes,25EEC@186801|Clostridia,36UMY@31979|Clostridiaceae 186801|Clostridia D Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase KKPNOBBG_00690 180332.JTGN01000003_gene2113 2.97e-205 574.0 COG3049@1|root,COG3049@2|Bacteria,1TRTI@1239|Firmicutes,249JA@186801|Clostridia 186801|Clostridia M Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase - - - - - - - - - - - - AAT,CBAH KKPNOBBG_00691 180332.JTGN01000003_gene2114 1.22e-282 778.0 COG1541@1|root,COG1541@2|Bacteria 2|Bacteria H phenylacetate-CoA ligase activity - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding KKPNOBBG_00692 180332.JTGN01000003_gene2115 4.79e-141 402.0 COG1136@1|root,COG1136@2|Bacteria,1TT4E@1239|Firmicutes,248M8@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_00693 180332.JTGN01000003_gene2116 0.0 1145.0 COG0577@1|root,COG0577@2|Bacteria,1TS3Z@1239|Firmicutes,24E8V@186801|Clostridia 186801|Clostridia V FtsX-like permease family - - - - - - - - - - - - FtsX,MacB_PCD KKPNOBBG_00694 180332.JTGN01000003_gene2117 3.13e-86 260.0 29H5D@1|root,3042Y@2|Bacteria,1V4BN@1239|Firmicutes,24ISQ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00695 180332.JTGN01000003_gene2118 7e-138 397.0 COG5434@1|root,COG5434@2|Bacteria,1TQXN@1239|Firmicutes,24APX@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3737 KKPNOBBG_00696 180332.JTGN01000003_gene2119 3.93e-66 207.0 COG4925@1|root,COG4925@2|Bacteria,1V9AI@1239|Firmicutes,24PAJ@186801|Clostridia 186801|Clostridia I sulfurtransferase activity - - - - - - - - - - - - Cyclophil_like KKPNOBBG_00697 180332.JTGN01000003_gene2120 5.12e-91 272.0 COG1280@1|root,COG1280@2|Bacteria,1V4SU@1239|Firmicutes,24KYP@186801|Clostridia 186801|Clostridia E LysE type translocator - - - - - - - - - - - - LysE KKPNOBBG_00698 1123075.AUDP01000006_gene2596 7.08e-64 203.0 COG4925@1|root,COG4925@2|Bacteria,1VA88@1239|Firmicutes,24N85@186801|Clostridia,3WJY1@541000|Ruminococcaceae 186801|Clostridia P Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - Cyclophil_like KKPNOBBG_00699 180332.JTGN01000003_gene2121 1.61e-243 673.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia 186801|Clostridia E Aminotransferase, class I patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_00700 1235790.C805_03701 4.68e-171 487.0 COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,25WCH@186806|Eubacteriaceae 186801|Clostridia C Domain of unknown function (DUF362) - - - ko:K07138 - - - - ko00000 - - - DUF362,Fer4 KKPNOBBG_00701 1291050.JAGE01000002_gene3691 7.72e-142 408.0 COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,3WHHN@541000|Ruminococcaceae 186801|Clostridia S permease - - - - - - - - - - - - ArsP_1 KKPNOBBG_00702 1504823.CCMM01000012_gene2243 6.18e-134 394.0 COG2220@1|root,COG2220@2|Bacteria,2NPNQ@2323|unclassified Bacteria 2|Bacteria S Beta-lactamase superfamily domain romA - - - - - - - - - - - Lactamase_B_2 KKPNOBBG_00704 1235792.C808_02591 2.54e-13 67.4 COG1961@1|root,COG1961@2|Bacteria,1UZM8@1239|Firmicutes,248B3@186801|Clostridia,27JNC@186928|unclassified Lachnospiraceae 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - Resolvase KKPNOBBG_00705 1280692.AUJL01000009_gene2896 1.98e-198 564.0 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247VU@186801|Clostridia,36HGT@31979|Clostridiaceae 186801|Clostridia L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase KKPNOBBG_00706 1437608.BBIA_0602 1.12e-97 292.0 2DB8R@1|root,2Z7SP@2|Bacteria,2GYVE@201174|Actinobacteria,4D1QK@85004|Bifidobacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - KKPNOBBG_00708 33035.JPJF01000041_gene344 1.48e-247 678.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00709 33035.JPJF01000041_gene345 7.08e-249 688.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily uhpT - - - - - - - - - - - MFS_1,MFS_Mycoplasma KKPNOBBG_00710 33035.JPJF01000041_gene346 7.96e-317 870.0 COG2508@1|root,COG2508@2|Bacteria,1VK8J@1239|Firmicutes 1239|Firmicutes QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_00711 33035.JPJF01000041_gene347 4.05e-306 843.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_00712 33035.JPJF01000041_gene348 6.52e-289 791.0 COG1592@1|root,COG1592@2|Bacteria 2|Bacteria C Rubrerythrin - - - - - - - - - - - - Metallophos,Rubrerythrin KKPNOBBG_00713 33035.JPJF01000041_gene349 2.07e-188 526.0 COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia,3Y02V@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Patatin KKPNOBBG_00714 33035.JPJF01000041_gene350 0.0 1609.0 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3Y0G0@572511|Blautia 186801|Clostridia G Putative carbohydrate binding domain - - 2.4.1.280 ko:K18675 ko00520,map00520 - R09942 RC00049 ko00000,ko00001,ko01000 - GH94 - Glyco_hydro_36,Glyco_transf_36 KKPNOBBG_00715 33035.JPJF01000041_gene351 0.0 933.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia 186801|Clostridia G phosphoglucomutase phosphomannomutase alpha beta alpha domain II - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV KKPNOBBG_00716 33035.JPJF01000041_gene352 0.0 1092.0 COG2972@1|root,COG2972@2|Bacteria,1TT5Q@1239|Firmicutes,24B15@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase KKPNOBBG_00717 33035.JPJF01000041_gene353 1.51e-297 815.0 COG1653@1|root,COG1653@2|Bacteria,1TQ75@1239|Firmicutes,24BNJ@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_00718 33035.JPJF01000041_gene354 1.54e-208 577.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_00719 33035.JPJF01000041_gene355 9.03e-185 515.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_00720 33035.JPJF01000041_gene356 2.03e-165 463.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UUV8@1239|Firmicutes,25KD0@186801|Clostridia,3Y1YD@572511|Blautia 186801|Clostridia T cheY-homologous receiver domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg KKPNOBBG_00721 33035.JPJF01000041_gene357 0.0 970.0 COG0248@1|root,COG0248@2|Bacteria,1TS3I@1239|Firmicutes,248EW@186801|Clostridia,3XYWZ@572511|Blautia 186801|Clostridia FP Ppx/GppA phosphatase family ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA KKPNOBBG_00722 33035.JPJF01000041_gene358 0.0 1362.0 COG0855@1|root,COG0855@2|Bacteria,1TNZM@1239|Firmicutes,248XY@186801|Clostridia,3XZ98@572511|Blautia 186801|Clostridia H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N KKPNOBBG_00726 33035.JPJF01000041_gene360 9.06e-152 432.0 COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,3XZBW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP KKPNOBBG_00727 33035.JPJF01000074_gene5049 7.85e-285 783.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia,3XYNC@572511|Blautia 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_00728 33035.JPJF01000074_gene5048 0.0 910.0 COG2508@1|root,COG2508@2|Bacteria,1VIT3@1239|Firmicutes,24JXW@186801|Clostridia,3Y0T9@572511|Blautia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_00729 33035.JPJF01000074_gene5047 9.93e-242 664.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00730 33035.JPJF01000074_gene5046 2.14e-258 707.0 COG0407@1|root,COG0407@2|Bacteria,1V5ND@1239|Firmicutes,24IEP@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00731 33035.JPJF01000074_gene5045 4.37e-310 848.0 COG2211@1|root,COG2211@2|Bacteria,1UJ7Q@1239|Firmicutes,24DJ1@186801|Clostridia 186801|Clostridia G TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_00732 33035.JPJF01000074_gene5044 9.15e-160 452.0 COG2162@1|root,COG2162@2|Bacteria,1V2RN@1239|Firmicutes,25DSA@186801|Clostridia 186801|Clostridia Q N-acetyltransferase - - 2.3.1.118 ko:K00675 - - - - ko00000,ko01000 - - - Acetyltransf_2 KKPNOBBG_00733 1300150.EMQU_0045 1.66e-43 154.0 COG3279@1|root,COG3279@2|Bacteria,1V392@1239|Firmicutes,4HHAI@91061|Bacilli,4B2ZH@81852|Enterococcaceae 91061|Bacilli K LytTr DNA-binding domain - - - ko:K07707 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg KKPNOBBG_00736 1163671.JAGI01000002_gene1593 1.26e-56 199.0 COG3290@1|root,COG3290@2|Bacteria,1UYTM@1239|Firmicutes,24CUA@186801|Clostridia,36FUX@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c_5 KKPNOBBG_00737 1345695.CLSA_c44440 3.55e-52 188.0 COG3290@1|root,COG3290@2|Bacteria,1UYTM@1239|Firmicutes,24CUA@186801|Clostridia,36FUX@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c_5 KKPNOBBG_00738 33035.JPJF01000074_gene5042 7.99e-112 322.0 COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,3Y0A5@572511|Blautia 186801|Clostridia I COG COG0671 Membrane-associated phospholipid phosphatase bcrC - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 KKPNOBBG_00739 33035.JPJF01000074_gene5041 3e-177 496.0 COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,25AZZ@186801|Clostridia 186801|Clostridia S Hydrolase - - - - - - - - - - - - Hydrolase_3 KKPNOBBG_00740 33035.JPJF01000074_gene5040 0.0 1266.0 COG0187@1|root,COG0187@2|Bacteria,1TRSZ@1239|Firmicutes,247ZY@186801|Clostridia,3XYT8@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 parE - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim KKPNOBBG_00741 33035.JPJF01000074_gene5039 0.0 1405.0 COG0188@1|root,COG0188@2|Bacteria,1TPNX@1239|Firmicutes,24ADK@186801|Clostridia,3XZJ2@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 gyrA_1 - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV KKPNOBBG_00742 33035.JPJF01000074_gene5038 5.34e-206 571.0 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,24DE3@186801|Clostridia,3Y009@572511|Blautia 186801|Clostridia P Psort location corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA KKPNOBBG_00743 33035.JPJF01000074_gene5037 8.68e-261 718.0 COG5279@1|root,COG5279@2|Bacteria,1TY2Q@1239|Firmicutes,24BDS@186801|Clostridia,3XZN1@572511|Blautia 186801|Clostridia D Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core KKPNOBBG_00744 33035.JPJF01000074_gene5036 5.04e-99 288.0 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,3Y03N@572511|Blautia 186801|Clostridia S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C KKPNOBBG_00745 33035.JPJF01000074_gene5035 4.18e-250 690.0 COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,3XZH6@572511|Blautia 186801|Clostridia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 KKPNOBBG_00746 33035.JPJF01000074_gene5034 6.45e-59 182.0 COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,3Y0GX@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 ylxR - - ko:K07742 - - - - ko00000 - - - DUF448 KKPNOBBG_00747 33035.JPJF01000074_gene5033 2.37e-62 191.0 COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia,3Y0DE@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Ribosomal_L7Ae KKPNOBBG_00748 33035.JPJF01000074_gene5032 0.0 1342.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,3XZRI@572511|Blautia 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N KKPNOBBG_00749 33035.JPJF01000074_gene5031 1.54e-82 244.0 COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3Y0A9@572511|Blautia 186801|Clostridia J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA KKPNOBBG_00750 33035.JPJF01000074_gene5030 1.03e-217 602.0 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3XZ2Y@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 KKPNOBBG_00751 33035.JPJF01000074_gene5029 1.27e-197 550.0 COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,3XYQ5@572511|Blautia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N KKPNOBBG_00752 33035.JPJF01000074_gene5028 3.1e-217 600.0 COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,3XZMT@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase KKPNOBBG_00753 33035.JPJF01000074_gene5027 0.0 1002.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,3XYUW@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU KKPNOBBG_00754 33035.JPJF01000074_gene5026 2.57e-171 479.0 COG0791@1|root,COG0791@2|Bacteria,1UBS0@1239|Firmicutes,25B2D@186801|Clostridia,3Y0CZ@572511|Blautia 186801|Clostridia M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,SH3_3 KKPNOBBG_00755 33035.JPJF01000074_gene5025 3.03e-54 170.0 COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3Y0EQ@572511|Blautia 186801|Clostridia J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 KKPNOBBG_00756 33035.JPJF01000074_gene5024 0.0 1346.0 COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,3XZKB@572511|Blautia 186801|Clostridia J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 KKPNOBBG_00757 33035.JPJF01000074_gene5023 1.8e-112 323.0 COG0602@1|root,COG0602@2|Bacteria,1V1HG@1239|Firmicutes,24HIJ@186801|Clostridia,3XZW3@572511|Blautia 186801|Clostridia C Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine nrdG - 1.97.1.4 ko:K04068 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM KKPNOBBG_00758 33035.JPJF01000074_gene5022 1.24e-114 329.0 COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24GHG@186801|Clostridia,3XZTE@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase KKPNOBBG_00759 33035.JPJF01000074_gene5020 4.1e-154 436.0 COG2820@1|root,COG2820@2|Bacteria,1TQ71@1239|Firmicutes,2482S@186801|Clostridia,3XYV1@572511|Blautia 186801|Clostridia F Phosphorylase superfamily - - - - - - - - - - - - PNP_UDP_1 KKPNOBBG_00760 33035.JPJF01000074_gene5019 4.2e-112 325.0 COG1309@1|root,COG1309@2|Bacteria,1UUVH@1239|Firmicutes,25MJR@186801|Clostridia,3Y1JB@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_00761 33035.JPJF01000074_gene5018 4.06e-267 733.0 COG3007@1|root,COG3007@2|Bacteria,1TWIF@1239|Firmicutes,249TW@186801|Clostridia,3XZSQ@572511|Blautia 186801|Clostridia I Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA) fabV GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050343,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.44,1.3.1.9 ko:K00209 ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212 M00083 R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase KKPNOBBG_00762 33035.JPJF01000074_gene5017 2.96e-167 473.0 COG5464@1|root,COG5464@2|Bacteria,1V2ZE@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4351 KKPNOBBG_00763 33035.JPJF01000074_gene5016 2.28e-218 602.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 KKPNOBBG_00764 33035.JPJF01000074_gene5015 1.05e-87 258.0 2E3QR@1|root,32YNK@2|Bacteria,1VENX@1239|Firmicutes,24QVR@186801|Clostridia,3Y0KX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF1292 KKPNOBBG_00765 33035.JPJF01000074_gene5014 0.0 949.0 COG0038@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0569@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3XZHT@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 clcA - - - - - - - - - - - TrkA_C,Voltage_CLC KKPNOBBG_00766 33035.JPJF01000074_gene5013 0.0 1160.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,3XZJM@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 KKPNOBBG_00767 33035.JPJF01000074_gene5012 4.23e-129 366.0 2943S@1|root,2ZRIE@2|Bacteria,1V3J6@1239|Firmicutes,24HEP@186801|Clostridia,3XZW0@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 KatE - - - - - - - - - - - - KKPNOBBG_00768 33035.JPJF01000074_gene5011 3.41e-174 493.0 2E6QY@1|root,331B3@2|Bacteria,1UI1C@1239|Firmicutes,24Z9X@186801|Clostridia,3Y0GV@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4203 KKPNOBBG_00769 33035.JPJF01000074_gene5010 1.19e-211 587.0 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3XYXI@572511|Blautia 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C KKPNOBBG_00770 33035.JPJF01000074_gene5009 3.26e-113 324.0 COG4894@1|root,COG4894@2|Bacteria,1V3WA@1239|Firmicutes,24MB0@186801|Clostridia,3Y1VJ@572511|Blautia 186801|Clostridia S LURP-one-related - - - - - - - - - - - - LOR KKPNOBBG_00771 33035.JPJF01000074_gene5008 1.47e-182 511.0 COG2227@1|root,COG2227@2|Bacteria,1UXZZ@1239|Firmicutes,24BIT@186801|Clostridia 186801|Clostridia H Methyltransferase - - - - - - - - - - - - Methyltransf_25 KKPNOBBG_00772 33035.JPJF01000074_gene5007 0.0 947.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,3XZK5@572511|Blautia 186801|Clostridia G Mannitol dehydrogenase C-terminal domain - - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C KKPNOBBG_00773 33035.JPJF01000074_gene5006 0.0 905.0 COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,3XZTB@572511|Blautia 186801|Clostridia G SAF uxaA - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF KKPNOBBG_00774 33035.JPJF01000074_gene5005 2.14e-232 640.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3Y15K@572511|Blautia 186801|Clostridia K helix_turn _helix lactose operon repressor ccpA - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_00775 33035.JPJF01000074_gene5004 1.67e-228 631.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24BWQ@186801|Clostridia,3Y2BW@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_00776 33035.JPJF01000074_gene5003 5.37e-88 260.0 COG3090@1|root,COG3090@2|Bacteria,1TUNS@1239|Firmicutes,25N0G@186801|Clostridia,3Y0U4@572511|Blautia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ KKPNOBBG_00777 411461.DORFOR_00430 1.16e-253 702.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DctM KKPNOBBG_00778 33035.JPJF01000021_gene3327 0.0 940.0 COG1904@1|root,COG1904@2|Bacteria,1TRI0@1239|Firmicutes,248C0@186801|Clostridia,3XYR6@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC KKPNOBBG_00779 33035.JPJF01000021_gene3328 1.63e-280 769.0 COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,3XYT0@572511|Blautia 186801|Clostridia F Psort location CytoplasmicMembrane, score 10.00 pyrP - - ko:K02824 - - - - ko00000,ko02000 2.A.40.1.1,2.A.40.1.2 - - Xan_ur_permease KKPNOBBG_00780 33035.JPJF01000021_gene3335 1.35e-221 614.0 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,3XZ2C@572511|Blautia 186801|Clostridia M Bacterial capsule synthesis protein PGA_cap capA - - ko:K07282 - - - - ko00000 - - - PGA_cap,Peptidase_M15 KKPNOBBG_00782 33035.JPJF01000021_gene3337 5.18e-149 420.0 COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,24B71@186801|Clostridia,3XZYT@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal dltR - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00783 33035.JPJF01000021_gene3338 2.52e-249 695.0 COG0642@1|root,COG2205@2|Bacteria,1UHUJ@1239|Firmicutes,25E2Z@186801|Clostridia,3XZRC@572511|Blautia 186801|Clostridia T GHKL domain dltS - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_00784 33035.JPJF01000021_gene3339 1.8e-140 401.0 COG5036@1|root,COG5036@2|Bacteria,1V1FZ@1239|Firmicutes,24FRH@186801|Clostridia,3Y09M@572511|Blautia 186801|Clostridia P VTC domain - - - - - - - - - - - - VTC KKPNOBBG_00785 33035.JPJF01000021_gene3340 1.15e-127 367.0 COG1285@1|root,COG1285@2|Bacteria,1V1GI@1239|Firmicutes,24G1I@186801|Clostridia,3XZXM@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4956) - - - - - - - - - - - - DUF4956 KKPNOBBG_00786 33035.JPJF01000021_gene3341 3.48e-274 770.0 arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,3XZHV@572511|Blautia 186801|Clostridia S Carbohydrate-binding domain-containing protein Cthe_2159 - GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062 - - - - - - - - - - Cthe_2159 KKPNOBBG_00787 33035.JPJF01000021_gene3342 3.78e-202 562.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3XZJH@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_00788 33035.JPJF01000021_gene3343 1.15e-299 819.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,3XYTJ@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP KKPNOBBG_00789 33035.JPJF01000021_gene3344 3.95e-98 285.0 COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,3Y0EE@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Rrf2 KKPNOBBG_00790 33035.JPJF01000021_gene3345 4.14e-198 550.0 COG2207@1|root,COG2207@2|Bacteria,1TQDS@1239|Firmicutes,24907@186801|Clostridia 186801|Clostridia K AraC family - - - - - - - - - - - - HTH_18 KKPNOBBG_00791 33035.JPJF01000021_gene3346 4.21e-189 531.0 2DBKZ@1|root,2Z9WA@2|Bacteria,1TRUJ@1239|Firmicutes,24ATT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - WYL KKPNOBBG_00792 33035.JPJF01000021_gene3347 3.24e-250 692.0 COG2378@1|root,COG2378@2|Bacteria,1TQYS@1239|Firmicutes,24B1B@186801|Clostridia 186801|Clostridia K WYL domain - - - - - - - - - - - - WYL KKPNOBBG_00793 33035.JPJF01000021_gene3348 7.7e-237 654.0 COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,24A7V@186801|Clostridia 186801|Clostridia O prohibitin homologues - - - - - - - - - - - - Band_7 KKPNOBBG_00794 33035.JPJF01000021_gene3349 1.39e-72 218.0 COG3877@1|root,COG3877@2|Bacteria,1VAFG@1239|Firmicutes,24MSP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2089 KKPNOBBG_00795 33035.JPJF01000021_gene3350 2.42e-65 201.0 2EA9N@1|root,305PD@2|Bacteria,1V547@1239|Firmicutes,24IYT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_00796 33035.JPJF01000021_gene3351 1.03e-46 150.0 2EAZP@1|root,3350I@2|Bacteria,1VHB0@1239|Firmicutes,24RTB@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00797 33035.JPJF01000021_gene3352 5.71e-136 385.0 COG1102@1|root,COG1102@2|Bacteria,1V79E@1239|Firmicutes,24GMW@186801|Clostridia,3XZZJ@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_00799 33035.JPJF01000021_gene3353 0.0 963.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3XYNQ@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 9.99 mleN_1 - - - - - - - - - - - Na_H_antiporter KKPNOBBG_00800 33035.JPJF01000021_gene3354 0.0 1454.0 COG5426@1|root,COG5426@2|Bacteria,1TPH0@1239|Firmicutes,24892@186801|Clostridia,3XZ5G@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 gnpA GO:0003674,GO:0003824,GO:0004645,GO:0005975,GO:0008150,GO:0008152,GO:0016740,GO:0016757,GO:0016758,GO:0044238,GO:0050500,GO:0071704 2.4.1.211 ko:K15533 - - - - ko00000,ko01000 - - - LBP_C,LBP_M,Lact_bio_phlase KKPNOBBG_00802 33035.JPJF01000021_gene3355 3.41e-221 612.0 COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,3XYQP@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 KKPNOBBG_00803 33035.JPJF01000021_gene3356 1.53e-186 522.0 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24A5W@186801|Clostridia,3XZZM@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_00804 33035.JPJF01000021_gene3357 2.87e-60 187.0 COG1476@1|root,COG1476@2|Bacteria,1V789@1239|Firmicutes,24IXV@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_00806 33035.JPJF01000021_gene3359 1.11e-54 171.0 2BD58@1|root,326SW@2|Bacteria,1USNX@1239|Firmicutes,25MVJ@186801|Clostridia,3Y1YZ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00807 33035.JPJF01000021_gene3360 5.55e-81 243.0 2E66T@1|root,330VC@2|Bacteria,1VHCY@1239|Firmicutes,24MYI@186801|Clostridia,3Y0NW@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_00808 33035.JPJF01000021_gene3361 1.14e-165 466.0 COG0345@1|root,COG0345@2|Bacteria,1TP1E@1239|Firmicutes,247SR@186801|Clostridia,3XZDC@572511|Blautia 186801|Clostridia E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer KKPNOBBG_00810 33035.JPJF01000021_gene3363 3.43e-96 281.0 COG2954@1|root,COG2954@2|Bacteria,1V7MS@1239|Firmicutes,24JER@186801|Clostridia,3Y0AV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - CYTH KKPNOBBG_00811 33035.JPJF01000021_gene3364 3.23e-115 331.0 COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia,3Y01K@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yajL - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI KKPNOBBG_00812 33035.JPJF01000021_gene3365 1.39e-280 771.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,3XYJC@572511|Blautia 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N KKPNOBBG_00813 33035.JPJF01000021_gene3366 1.72e-134 381.0 COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,3XYT9@572511|Blautia 186801|Clostridia OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease KKPNOBBG_00814 33035.JPJF01000021_gene3367 1.37e-305 833.0 COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,3XYHZ@572511|Blautia 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX KKPNOBBG_00815 33035.JPJF01000021_gene3368 0.0 1397.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,3XYJU@572511|Blautia 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C KKPNOBBG_00816 33035.JPJF01000021_gene3369 1.72e-136 386.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,3XZB9@572511|Blautia 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 KKPNOBBG_00817 33035.JPJF01000021_gene3370 3.35e-269 738.0 COG0637@1|root,COG0637@2|Bacteria,1V1NW@1239|Firmicutes,24G37@186801|Clostridia,3Y0ZE@572511|Blautia 186801|Clostridia S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3,HAD_2 KKPNOBBG_00818 33035.JPJF01000021_gene3371 2.41e-196 545.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3XZE9@572511|Blautia 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA2 - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran KKPNOBBG_00819 33035.JPJF01000021_gene3372 5.67e-197 546.0 COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,3XZ7W@572511|Blautia 186801|Clostridia P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfA2 - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran KKPNOBBG_00820 33035.JPJF01000021_gene3373 1.85e-172 483.0 COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,3XYPD@572511|Blautia 186801|Clostridia P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates ecfT - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ KKPNOBBG_00821 33035.JPJF01000021_gene3374 3.65e-174 486.0 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,3XYU9@572511|Blautia 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 KKPNOBBG_00822 33035.JPJF01000021_gene3375 0.0 1031.0 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,3XYYI@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 KKPNOBBG_00823 33035.JPJF01000021_gene3376 1.93e-117 336.0 COG1853@1|root,COG1853@2|Bacteria,1V41U@1239|Firmicutes,24HTA@186801|Clostridia,3Y0NR@572511|Blautia 186801|Clostridia S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct KKPNOBBG_00824 33035.JPJF01000021_gene3377 9.16e-197 548.0 COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia,3XZ37@572511|Blautia 186801|Clostridia S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans KKPNOBBG_00825 33035.JPJF01000021_gene3378 3.85e-38 128.0 2BCQI@1|root,326AY@2|Bacteria,1US91@1239|Firmicutes,25A84@186801|Clostridia,3Y22C@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00826 33035.JPJF01000021_gene3379 2.26e-45 147.0 2DRX4@1|root,33DGR@2|Bacteria,1VKQ3@1239|Firmicutes,24URP@186801|Clostridia,3Y0RT@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00827 33035.JPJF01000021_gene3380 4.64e-280 780.0 COG2199@1|root,COG2199@2|Bacteria,1VTNV@1239|Firmicutes,24Y0C@186801|Clostridia,3Y1SI@572511|Blautia 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF KKPNOBBG_00828 33035.JPJF01000021_gene3381 1.04e-41 136.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,3Y0CS@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD KKPNOBBG_00829 33035.JPJF01000021_gene3382 9.31e-309 842.0 COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,3XYP9@572511|Blautia 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 KKPNOBBG_00830 33035.JPJF01000021_gene3383 1.42e-218 603.0 COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,3XZ6C@572511|Blautia 186801|Clostridia F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17585 OMPdecase KKPNOBBG_00831 33035.JPJF01000021_gene3384 1.78e-166 467.0 COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3XZA9@572511|Blautia 186801|Clostridia C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 KKPNOBBG_00832 33035.JPJF01000021_gene3385 3.18e-206 571.0 COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3XZ9C@572511|Blautia 186801|Clostridia F Catalyzes the conversion of dihydroorotate to orotate pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh KKPNOBBG_00833 33035.JPJF01000021_gene3386 7.4e-154 432.0 COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia,3XYW9@572511|Blautia 186801|Clostridia F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran KKPNOBBG_00834 1121115.AXVN01000042_gene3025 5.95e-13 63.2 2DRBT@1|root,33B4Z@2|Bacteria,1VMZQ@1239|Firmicutes,24UIT@186801|Clostridia,3Y0RQ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00835 33035.JPJF01000021_gene3388 7.63e-107 308.0 COG4767@1|root,COG4767@2|Bacteria,1VAH6@1239|Firmicutes,24MQR@186801|Clostridia,3Y09R@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - VanZ KKPNOBBG_00836 33035.JPJF01000021_gene3389 2.17e-59 184.0 2EENY@1|root,338GS@2|Bacteria,1VJM1@1239|Firmicutes,24T09@186801|Clostridia,3Y0JX@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_00837 33035.JPJF01000021_gene3390 1.43e-116 335.0 COG1896@1|root,COG1896@2|Bacteria,1V3MK@1239|Firmicutes,24IBW@186801|Clostridia,3XZ0F@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07023 - - - - ko00000 - - - HD_3 KKPNOBBG_00838 33035.JPJF01000021_gene3391 0.0 1214.0 COG2309@1|root,COG2309@2|Bacteria,1TSPE@1239|Firmicutes,24A6S@186801|Clostridia,3XYTQ@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Peptidase_M29 KKPNOBBG_00839 33035.JPJF01000021_gene3393 9.2e-110 316.0 COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3XZ51@572511|Blautia 186801|Clostridia F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC KKPNOBBG_00840 33035.JPJF01000148_gene1663 1.36e-244 672.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,3XYWD@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C KKPNOBBG_00841 33035.JPJF01000148_gene1662 2.3e-135 384.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,3XYPA@572511|Blautia 186801|Clostridia F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04225 Formyl_trans_N KKPNOBBG_00842 33035.JPJF01000148_gene1661 1.03e-301 823.0 COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3XYZ3@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N KKPNOBBG_00843 33035.JPJF01000148_gene1660 1.73e-77 231.0 COG1725@1|root,COG1725@2|Bacteria,1V743@1239|Firmicutes,24J7Q@186801|Clostridia,3Y040@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_00844 33035.JPJF01000148_gene1659 0.0 1511.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3XYKC@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 9.98 clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N KKPNOBBG_00845 33035.JPJF01000148_gene1658 1.92e-88 260.0 2AU16@1|root,31JM9@2|Bacteria,1V6CJ@1239|Firmicutes,24JBF@186801|Clostridia,3Y05D@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_00846 33035.JPJF01000148_gene1657 2.22e-311 850.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,3XYVQ@572511|Blautia 186801|Clostridia L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C KKPNOBBG_00850 1226325.HMPREF1548_06389 8.03e-31 130.0 2CF9F@1|root,32VJR@2|Bacteria,1UKPA@1239|Firmicutes 1239|Firmicutes S CRISPR-associated (Cas) DxTHG family - - - - - - - - - - - - Cas_DxTHG KKPNOBBG_00851 397291.C804_01799 1.99e-170 509.0 COG1337@1|root,COG1337@2|Bacteria,1UZIC@1239|Firmicutes,24K3J@186801|Clostridia,27NE8@186928|unclassified Lachnospiraceae 186801|Clostridia L RAMP superfamily - - - - - - - - - - - - RAMPs KKPNOBBG_00853 397291.C804_01797 3.65e-105 327.0 COG1337@1|root,COG1337@2|Bacteria,1V6T4@1239|Firmicutes,24J7Z@186801|Clostridia,27NH2@186928|unclassified Lachnospiraceae 186801|Clostridia L RAMP superfamily - - - - - - - - - - - - RAMPs KKPNOBBG_00854 397291.C804_01796 7.41e-110 343.0 COG1337@1|root,COG1337@2|Bacteria,1VB9Y@1239|Firmicutes,24KU1@186801|Clostridia 186801|Clostridia L RAMP superfamily - - - ko:K19134 - - - - ko00000,ko02048 - - - RAMPs KKPNOBBG_00855 397291.C804_01795 6.56e-54 177.0 COG1337@1|root,COG1337@2|Bacteria,1VEYV@1239|Firmicutes 1239|Firmicutes L RAMP superfamily - - - - - - - - - - - - RAMPs KKPNOBBG_00856 1408311.JNJM01000019_gene1872 3.29e-142 426.0 COG1353@1|root,COG1353@2|Bacteria,1UZM3@1239|Firmicutes,24KWD@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_00857 500632.CLONEX_02806 7.02e-105 310.0 COG1737@1|root,COG1737@2|Bacteria,1TS9A@1239|Firmicutes,24HCX@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS KKPNOBBG_00858 1226325.HMPREF1548_03116 5.33e-102 300.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,24B0N@186801|Clostridia,36FGH@31979|Clostridiaceae 186801|Clostridia S Maltose acetyltransferase - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_00859 1235792.C808_02122 6.02e-80 245.0 COG0546@1|root,COG0546@2|Bacteria,1V9Z4@1239|Firmicutes,24QFD@186801|Clostridia 186801|Clostridia S TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E - - 3.6.1.1 ko:K06019 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_00860 33035.JPJF01000032_gene2149 0.0 1576.0 COG0426@1|root,COG1251@1|root,COG0426@2|Bacteria,COG1251@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,3XZNS@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 fprA2 - 1.6.3.4 ko:K22405 - - - - ko00000,ko01000 - - - Flavodoxin_1,Lactamase_B,Pyr_redox_2 KKPNOBBG_00861 33035.JPJF01000032_gene2151 3.12e-165 480.0 COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3XZ4Y@572511|Blautia 186801|Clostridia M Psort location Extracellular, score - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 KKPNOBBG_00862 33035.JPJF01000032_gene2152 2.43e-201 573.0 COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3XZ4Y@572511|Blautia 186801|Clostridia M Psort location Extracellular, score - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 KKPNOBBG_00863 33035.JPJF01000032_gene2153 0.0 956.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,3XYPP@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF KKPNOBBG_00864 33035.JPJF01000032_gene2154 4.59e-88 259.0 COG4747@1|root,COG4747@2|Bacteria,1V4AA@1239|Firmicutes,2593P@186801|Clostridia,3Y1XD@572511|Blautia 186801|Clostridia S ACT domain protein - - - - - - - - - - - - - KKPNOBBG_00865 33035.JPJF01000032_gene2155 6.74e-126 359.0 COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,3Y05Y@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 iorB - 1.2.7.8 ko:K00180 - - - - br01601,ko00000,ko01000 - - - POR KKPNOBBG_00866 33035.JPJF01000032_gene2156 0.0 1118.0 COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,3XYPI@572511|Blautia 186801|Clostridia C oxidoreductase subunit alpha iorA - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,POR_N,TPP_enzyme_C KKPNOBBG_00867 33035.JPJF01000032_gene2157 5.87e-313 852.0 COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3Y0PX@572511|Blautia 186801|Clostridia H AMP-binding enzyme paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 KKPNOBBG_00868 33035.JPJF01000032_gene2158 1.06e-70 215.0 2E5GB@1|root,33080@2|Bacteria,1VF18@1239|Firmicutes,24R5R@186801|Clostridia,3Y0IK@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - CorC_HlyC KKPNOBBG_00869 742733.HMPREF9469_01397 6.31e-169 493.0 COG2865@1|root,COG2865@2|Bacteria,1TRTZ@1239|Firmicutes,25CHW@186801|Clostridia,2208Y@1506553|Lachnoclostridium 186801|Clostridia K Putative ATP-dependent DNA helicase recG C-terminal - - - - - - - - - - - - AlbA_2,HATPase_c_4,HTH_24 KKPNOBBG_00870 33035.JPJF01000032_gene2160 0.0 897.0 COG1113@1|root,COG1113@2|Bacteria,1UHVM@1239|Firmicutes 1239|Firmicutes E amino acid - - - ko:K03294,ko:K11737 - - - - ko00000,ko02000 2.A.3.1.7,2.A.3.2 - - AA_permease_2 KKPNOBBG_00871 33035.JPJF01000032_gene2161 2.64e-286 784.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3XZ14@572511|Blautia 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_1_2,Histidinol_dh KKPNOBBG_00872 33035.JPJF01000032_gene2162 5.09e-268 737.0 COG0789@1|root,COG0789@2|Bacteria,1V12J@1239|Firmicutes,24DI4@186801|Clostridia 186801|Clostridia K regulatory protein MerR - - - - - - - - - - - - MerR_1,Methyltransf_25,Methyltransf_31 KKPNOBBG_00873 1449050.JNLE01000005_gene5173 9.76e-86 258.0 COG1476@1|root,COG1476@2|Bacteria,1V7I5@1239|Firmicutes,24KRY@186801|Clostridia,36J6U@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 KKPNOBBG_00874 1506994.JNLQ01000003_gene3783 1.49e-179 516.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24BP7@186801|Clostridia,4BXX1@830|Butyrivibrio 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 KKPNOBBG_00875 33035.JPJF01000032_gene2163 1.09e-209 581.0 COG0657@1|root,COG0657@2|Bacteria,1V1UH@1239|Firmicutes,248MF@186801|Clostridia,3Y1Q0@572511|Blautia 186801|Clostridia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 KKPNOBBG_00876 33035.JPJF01000008_gene1188 1.52e-254 736.0 COG2207@1|root,COG3664@1|root,COG2207@2|Bacteria,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,3Y206@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 39 - - - - - - - - - - - - AraC_binding,Glyco_hydro_39,HTH_18 KKPNOBBG_00878 33035.JPJF01000032_gene2164 6.93e-299 816.0 COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,3XYMU@572511|Blautia 186801|Clostridia E M18 family aminopeptidase apeB - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 KKPNOBBG_00879 33035.JPJF01000032_gene2165 0.0 883.0 COG0531@1|root,COG0531@2|Bacteria,1TRFS@1239|Firmicutes,248WW@186801|Clostridia,3Y0YC@572511|Blautia 186801|Clostridia E Amino acid permease NPD5_3681 - - - - - - - - - - - AA_permease_2 KKPNOBBG_00880 33035.JPJF01000032_gene2166 0.0 1468.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3XYHY@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score xdhD - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 KKPNOBBG_00881 33035.JPJF01000032_gene2167 1.43e-105 305.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia,3XZVY@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 hcrC - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 KKPNOBBG_00882 33035.JPJF01000032_gene2168 9.67e-168 472.0 COG1319@1|root,COG1319@2|Bacteria,1TSNH@1239|Firmicutes,24A57@186801|Clostridia,3XZ2J@572511|Blautia 186801|Clostridia C COG COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 KKPNOBBG_00883 33035.JPJF01000032_gene2169 5.67e-206 574.0 COG2367@1|root,COG2367@2|Bacteria,1VHF8@1239|Firmicutes 1239|Firmicutes V Beta-lactamase enzyme family - - - - - - - - - - - - Beta-lactamase2 KKPNOBBG_00884 33035.JPJF01000032_gene2170 6.26e-305 834.0 COG0534@1|root,COG0534@2|Bacteria,1TRR0@1239|Firmicutes,249UC@186801|Clostridia,3XZB1@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_00885 33035.JPJF01000032_gene2171 1.43e-137 390.0 COG3103@1|root,COG3103@2|Bacteria,1US8A@1239|Firmicutes,25A7D@186801|Clostridia,3Y1R5@572511|Blautia 186801|Clostridia T Bacterial SH3 domain homologues - - - - - - - - - - - - SH3_3 KKPNOBBG_00886 33035.JPJF01000032_gene2177 1.62e-169 474.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3XZ2M@572511|Blautia 186801|Clostridia S AIR carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC KKPNOBBG_00887 33035.JPJF01000032_gene2178 1.59e-244 671.0 COG2502@1|root,COG2502@2|Bacteria,1TP28@1239|Firmicutes,248S4@186801|Clostridia,3XYZ8@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score asnA - 6.3.1.1 ko:K01914 ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230 - R00483 RC00010 ko00000,ko00001,ko01000 - - - AsnA KKPNOBBG_00888 33035.JPJF01000032_gene2179 3.19e-295 810.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,2481G@186801|Clostridia,3XYVW@572511|Blautia 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_00889 33035.JPJF01000032_gene2180 0.0 1006.0 COG3534@1|root,COG3534@2|Bacteria,1TRY9@1239|Firmicutes,2497J@186801|Clostridia,3Y1AY@572511|Blautia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus abfA - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C KKPNOBBG_00890 33035.JPJF01000032_gene2181 1.24e-196 546.0 COG0395@1|root,COG0395@2|Bacteria,1TT5G@1239|Firmicutes,249MU@186801|Clostridia,3Y17N@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17236 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - BPD_transp_1 KKPNOBBG_00891 33035.JPJF01000032_gene2182 2.35e-211 584.0 COG1175@1|root,COG1175@2|Bacteria,1TRSP@1239|Firmicutes,24906@186801|Clostridia,3Y17F@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17235 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - BPD_transp_1 KKPNOBBG_00892 33035.JPJF01000032_gene2183 0.0 889.0 COG1653@1|root,COG1653@2|Bacteria,1TS9Z@1239|Firmicutes,2490T@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein araN - - ko:K17234 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_00893 33035.JPJF01000032_gene2184 0.0 1241.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia,3Y0XI@572511|Blautia 186801|Clostridia S Beta-L-arabinofuranosidase, GH127 - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 KKPNOBBG_00894 33035.JPJF01000032_gene2185 1.32e-245 676.0 COG1609@1|root,COG1609@2|Bacteria,1TRWK@1239|Firmicutes,24DAV@186801|Clostridia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_00895 33035.JPJF01000032_gene2186 0.0 1045.0 COG3940@1|root,COG3940@2|Bacteria,1TRHI@1239|Firmicutes,24AG6@186801|Clostridia 186801|Clostridia M Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - AbfB,Big_4,Dockerin_1,Glyco_hydro_43 KKPNOBBG_00896 592026.GCWU0000282_002194 1.56e-152 441.0 COG4225@1|root,COG4225@2|Bacteria,1TRJ7@1239|Firmicutes,24806@186801|Clostridia 186801|Clostridia S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 KKPNOBBG_00897 180332.JTGN01000006_gene3234 8.49e-123 362.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia 186801|Clostridia E Oxidoreductase NAD-binding domain protein - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_00898 1217720.ALOX01000062_gene2292 1.55e-51 180.0 COG1063@1|root,COG1063@2|Bacteria,1MUK8@1224|Proteobacteria,2TQZT@28211|Alphaproteobacteria,2JVYT@204441|Rhodospirillales 204441|Rhodospirillales E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_00899 1502851.FG93_06172 2.1e-54 184.0 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00900 1150399.AQYK01000002_gene3093 1.11e-59 199.0 COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria,4FMNC@85023|Microbacteriaceae 201174|Actinobacteria G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_00901 1041139.KB902724_gene4128 1.02e-07 62.8 COG1653@1|root,COG1653@2|Bacteria,1QKXW@1224|Proteobacteria,2VETE@28211|Alphaproteobacteria,4B914@82115|Rhizobiaceae 28211|Alphaproteobacteria G ABC-type sugar transport system, periplasmic component malE - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_00902 1033743.CAES01000015_gene2377 2.91e-92 279.0 COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,26Z0J@186822|Paenibacillaceae 91061|Bacilli K UTRA frlR3 - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_00903 180332.JTGN01000004_gene2633 2.15e-173 492.0 COG1063@1|root,COG1063@2|Bacteria,1U5I6@1239|Firmicutes,24C8T@186801|Clostridia 186801|Clostridia E COG COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 KKPNOBBG_00904 742738.HMPREF9460_00156 4.09e-157 449.0 COG3386@1|root,COG3386@2|Bacteria,1V0DH@1239|Firmicutes,24CIJ@186801|Clostridia 186801|Clostridia G SMP-30/Gluconolaconase/LRE-like region - - - - - - - - - - - - SGL KKPNOBBG_00905 1033743.CAES01000015_gene2376 3.93e-271 753.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,4HBRJ@91061|Bacilli 91061|Bacilli G xylulose kinase - - 2.7.1.12 ko:K00851 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 - R01737 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_00906 526218.Sterm_3405 9.86e-138 402.0 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_00907 658086.HMPREF0994_04501 1.69e-155 446.0 COG0673@1|root,COG0673@2|Bacteria,1V6R6@1239|Firmicutes,249EW@186801|Clostridia,27PFJ@186928|unclassified Lachnospiraceae 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_00908 658086.HMPREF0994_04499 3.16e-179 520.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,27IKI@186928|unclassified Lachnospiraceae 186801|Clostridia G FGGY family of carbohydrate kinases, N-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_00909 309799.DICTH_1885 3.83e-151 444.0 COG1486@1|root,COG1486@2|Bacteria 2|Bacteria G melibiose metabolic process - - 3.2.1.22,3.2.1.86 ko:K01222,ko:K07406 ko00010,ko00052,ko00500,ko00561,ko00600,ko00603,map00010,map00052,map00500,map00561,map00600,map00603 - R00839,R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05133,R05134,R05549,R05961,R06091 RC00049,RC00059,RC00171,RC00451,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_00910 428125.CLOLEP_02870 1.93e-83 257.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,24GX7@186801|Clostridia,3WK6P@541000|Ruminococcaceae 186801|Clostridia K DeoR C terminal sensor domain - - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_00911 428125.CLOLEP_02870 1.23e-96 291.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,24GX7@186801|Clostridia,3WK6P@541000|Ruminococcaceae 186801|Clostridia K DeoR C terminal sensor domain - - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_00912 428125.CLOLEP_02875 3.95e-239 668.0 2EZ3K@1|root,33S9T@2|Bacteria,1VSQ5@1239|Firmicutes,24ZIX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00913 553973.CLOHYLEM_06367 1.2e-107 318.0 COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,220D6@1506553|Lachnoclostridium 186801|Clostridia K UbiC transcription regulator-associated domain protein - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_00914 1235798.C817_03634 3.54e-171 484.0 COG0169@1|root,COG0169@2|Bacteria,1TRRZ@1239|Firmicutes,24ZBH@186801|Clostridia 186801|Clostridia E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) - - - - - - - - - - - - - KKPNOBBG_00915 1235798.C817_03633 9.93e-92 273.0 COG2140@1|root,COG2140@2|Bacteria,1V4TG@1239|Firmicutes,24M04@186801|Clostridia 186801|Clostridia G Glucose-6-phosphate isomerase (GPI) - - 5.3.1.9 ko:K06859 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000 - - - GPI KKPNOBBG_00916 1235798.C817_03632 4.82e-108 324.0 COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,249N0@186801|Clostridia 186801|Clostridia S metal-dependent hydrolase with the TIM-barrel fold - - - ko:K07048 - - - - ko00000 - - - PTE KKPNOBBG_00917 1235798.C817_03631 3.96e-142 410.0 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,25MSV@186801|Clostridia,27WV1@189330|Dorea 186801|Clostridia EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_00918 33035.JPJF01000032_gene2188 0.0 867.0 COG2211@1|root,COG2211@2|Bacteria,1UJ7Q@1239|Firmicutes,24DJ1@186801|Clostridia 186801|Clostridia G TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_00919 33035.JPJF01000032_gene2189 1.67e-241 662.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_00920 33035.JPJF01000032_gene2190 3.7e-298 813.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3XYZQ@572511|Blautia 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT KKPNOBBG_00922 33035.JPJF01000032_gene2191 9.16e-209 577.0 COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia 186801|Clostridia Q fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - FAA_hydrolase KKPNOBBG_00923 33035.JPJF01000032_gene2192 8.26e-90 264.0 COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,3Y00A@572511|Blautia 186801|Clostridia K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type KKPNOBBG_00924 33035.JPJF01000032_gene2193 5.1e-213 589.0 COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,3XYTI@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Arginase KKPNOBBG_00925 33035.JPJF01000032_gene2194 6.21e-148 418.0 COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia 186801|Clostridia S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 KKPNOBBG_00926 33035.JPJF01000032_gene2195 4.27e-90 266.0 2CAVT@1|root,304CC@2|Bacteria,1V4J6@1239|Firmicutes,24HQA@186801|Clostridia,3Y07W@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2798 KKPNOBBG_00928 476272.RUMHYD_00139 8.73e-272 754.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,3XYPP@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 putP - - ko:K03307,ko:K11928 - - - - ko00000,ko02000 2.A.21,2.A.21.2 - - SSF KKPNOBBG_00931 33035.JPJF01000032_gene2200 3.66e-66 202.0 COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,24MSE@186801|Clostridia,3Y0AY@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score mntR_1 - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress KKPNOBBG_00932 33035.JPJF01000032_gene2201 4.03e-238 659.0 COG0438@1|root,COG0438@2|Bacteria,1UY0J@1239|Firmicutes,248KC@186801|Clostridia 186801|Clostridia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Acyltransferase,Glyco_transf_4,Glycos_transf_1 KKPNOBBG_00933 33035.JPJF01000032_gene2202 6.76e-168 470.0 COG0204@1|root,COG0204@2|Bacteria,1V9P5@1239|Firmicutes,24K2Z@186801|Clostridia 186801|Clostridia I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase KKPNOBBG_00934 33035.JPJF01000032_gene2203 7.65e-310 896.0 COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,2493H@186801|Clostridia,3XYNF@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01421 - - - - ko00000 - - - ABC2_membrane_3,DUF3533 KKPNOBBG_00935 33035.JPJF01000032_gene2205 1.36e-130 371.0 COG1309@1|root,COG1309@2|Bacteria,1V89E@1239|Firmicutes,24JQ7@186801|Clostridia,3Y03H@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_00936 33035.JPJF01000032_gene2206 5.31e-156 440.0 COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,3Y1PP@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF975) - - - - - - - - - - - - DUF975 KKPNOBBG_00937 33035.JPJF01000032_gene2207 1.83e-187 525.0 COG0524@1|root,COG0524@2|Bacteria,1UYF8@1239|Firmicutes,25MKN@186801|Clostridia,3Y0ZH@572511|Blautia 186801|Clostridia G Phosphomethylpyrimidine kinase - - - - - - - - - - - - PfkB KKPNOBBG_00938 33035.JPJF01000032_gene2208 1.54e-201 565.0 COG1476@1|root,COG1476@2|Bacteria,1V7TA@1239|Firmicutes,2496Q@186801|Clostridia,3XZX8@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_19,HTH_3,HTH_31 KKPNOBBG_00939 33035.JPJF01000032_gene2209 7.81e-113 324.0 COG1528@1|root,COG1528@2|Bacteria,1V1BJ@1239|Firmicutes,24FUF@186801|Clostridia,3XZXQ@572511|Blautia 186801|Clostridia P Ferritin-like domain ftnA - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin KKPNOBBG_00940 33035.JPJF01000032_gene2211 2.01e-210 585.0 COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,247X6@186801|Clostridia,3XZ19@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 yeiH - - - - - - - - - - - Cons_hypoth698 KKPNOBBG_00941 33035.JPJF01000032_gene2212 5.82e-193 537.0 COG0583@1|root,COG0583@2|Bacteria,1TSNI@1239|Firmicutes,249QS@186801|Clostridia,3XZUG@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_00942 33035.JPJF01000032_gene2213 2.52e-209 583.0 2C2TA@1|root,2Z7T7@2|Bacteria,1TS53@1239|Firmicutes,248BA@186801|Clostridia,3XZQ0@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - FUSC_2 KKPNOBBG_00943 33035.JPJF01000032_gene2214 6.71e-92 270.0 COG1846@1|root,COG1846@2|Bacteria,1VBKN@1239|Firmicutes,24PC9@186801|Clostridia,3Y216@572511|Blautia 186801|Clostridia K Winged helix DNA-binding domain - - - - - - - - - - - - HTH_27,MarR,MarR_2 KKPNOBBG_00944 33035.JPJF01000032_gene2215 7.91e-196 544.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1TPMG@1239|Firmicutes,25E9N@186801|Clostridia,3Y08Q@572511|Blautia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - ARD,AraC_binding,Cupin_2,HTH_18 KKPNOBBG_00945 33035.JPJF01000032_gene2216 9.2e-270 736.0 COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,247RB@186801|Clostridia,3XZ36@572511|Blautia 186801|Clostridia H Catalyzes the dehydration of D-mannonate uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA KKPNOBBG_00946 33035.JPJF01000032_gene2217 0.0 1032.0 COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,3XYQY@572511|Blautia 186801|Clostridia G Mannitol dehydrogenase Rossmann domain - - 1.1.1.57 ko:K00040 ko00040,ko01100,map00040,map01100 M00061 R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C KKPNOBBG_00947 33035.JPJF01000032_gene2218 1.49e-72 218.0 COG3304@1|root,COG3304@2|Bacteria,1VADH@1239|Firmicutes,24NFV@186801|Clostridia,3Y0CX@572511|Blautia 186801|Clostridia S Inner membrane component domain yccF - - - - - - - - - - - YccF KKPNOBBG_00948 33035.JPJF01000032_gene2219 5.62e-88 259.0 COG3064@1|root,COG3064@2|Bacteria,1VB1V@1239|Firmicutes,25N5W@186801|Clostridia,3Y1TQ@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_00949 33035.JPJF01000032_gene2220 0.0 2542.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,3Y288@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3 KKPNOBBG_00950 33035.JPJF01000032_gene2221 6.58e-169 475.0 COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TPUE@1239|Firmicutes,24AS8@186801|Clostridia,3XZK4@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - GyrI-like,MerR_1 KKPNOBBG_00951 33035.JPJF01000032_gene2222 0.0 1157.0 COG2200@1|root,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,dCache_1 KKPNOBBG_00952 33035.JPJF01000032_gene2223 2.29e-283 783.0 COG2186@1|root,COG2188@1|root,COG2186@2|Bacteria,COG2188@2|Bacteria,1TSP3@1239|Firmicutes,24DQE@186801|Clostridia 186801|Clostridia K Transcriptional regulator, GntR family - - - - - - - - - - - - GntR KKPNOBBG_00954 33035.JPJF01000032_gene2224 0.0 1062.0 COG3044@1|root,COG3044@2|Bacteria,1TPJ9@1239|Firmicutes,248G5@186801|Clostridia,3XYQT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - ABC_ATPase KKPNOBBG_00955 33035.JPJF01000032_gene2225 7.9e-246 674.0 COG0479@1|root,COG0479@2|Bacteria,1TP8R@1239|Firmicutes,247QI@186801|Clostridia,3XZSA@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain asrA - - ko:K16950 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4_22 KKPNOBBG_00956 33035.JPJF01000032_gene2226 1.13e-161 454.0 COG0543@1|root,COG0543@2|Bacteria,1TQBZ@1239|Firmicutes,248GQ@186801|Clostridia,3XYPT@572511|Blautia 186801|Clostridia C Oxidoreductase NAD-binding domain asrB - - ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - DHODB_Fe-S_bind,NAD_binding_1 KKPNOBBG_00957 33035.JPJF01000032_gene2227 1.5e-231 637.0 COG2221@1|root,COG2221@2|Bacteria,1TR7P@1239|Firmicutes,2493K@186801|Clostridia,3XZCG@572511|Blautia 186801|Clostridia C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family asrC - - ko:K00385 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - Fer4,Fer4_10,Fer4_21,Fer4_4,Fer4_6,NIR_SIR,NIR_SIR_ferr KKPNOBBG_00958 33035.JPJF01000032_gene2228 2.84e-239 658.0 COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,248FK@186801|Clostridia,3XZP8@572511|Blautia 186801|Clostridia S COG COG0656 Aldo keto reductases, related to diketogulonate reductase - - 1.1.1.2 ko:K00002 ko00010,ko00040,ko00561,ko00930,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00561,map00930,map01100,map01110,map01120,map01130,map01220 M00014 R00746,R01041,R01481,R05231 RC00087,RC00088,RC00099,RC00108 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Aldo_ket_red KKPNOBBG_00959 33035.JPJF01000032_gene2229 3.99e-267 731.0 COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,24ATX@186801|Clostridia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_00960 33035.JPJF01000032_gene2230 1.78e-169 477.0 29WCR@1|root,30HYE@2|Bacteria,1UUV3@1239|Firmicutes,25KCV@186801|Clostridia,3Y1QM@572511|Blautia 186801|Clostridia S TraX protein - - - - - - - - - - - - TraX KKPNOBBG_00961 97139.C824_03119 2.08e-149 437.0 COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia,36G4K@31979|Clostridiaceae 186801|Clostridia M Peptidase family M23 - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 KKPNOBBG_00962 33035.JPJF01000089_gene101 2.27e-69 209.0 arCOG15062@1|root,32Y8D@2|Bacteria,1VEUQ@1239|Firmicutes,24TKJ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - PQ-loop KKPNOBBG_00963 33035.JPJF01000089_gene102 6.3e-129 366.0 COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,3XZI9@572511|Blautia 186801|Clostridia C COG COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain fumB - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C KKPNOBBG_00964 33035.JPJF01000089_gene103 2.76e-205 567.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,3XZ8S@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 fumA - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase KKPNOBBG_00965 33035.JPJF01000089_gene104 0.0 986.0 COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,3Y1CZ@572511|Blautia 186801|Clostridia C Glucose inhibited division protein A - - 1.3.5.1,1.3.5.4,1.3.99.33 ko:K00239,ko:K00244,ko:K17363 ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164,R10330 RC00045,RC00669 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FMN_bind,FMN_red KKPNOBBG_00966 33035.JPJF01000089_gene105 1.19e-154 434.0 COG4656@1|root,COG4656@2|Bacteria,1UY26@1239|Firmicutes,24D3I@186801|Clostridia,3Y0XC@572511|Blautia 186801|Clostridia C 2Fe-2S iron-sulfur cluster binding domain - - - - - - - - - - - - Fer2_4,Fer4_7,Fer4_9 KKPNOBBG_00967 33035.JPJF01000089_gene106 1.87e-215 593.0 COG0543@1|root,COG0543@2|Bacteria,1TQBZ@1239|Firmicutes,248GQ@186801|Clostridia,3Y1HE@572511|Blautia 186801|Clostridia CH Oxidoreductase FAD-binding domain - - - - - - - - - - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 KKPNOBBG_00968 33035.JPJF01000089_gene107 6.05e-250 686.0 COG0479@1|root,COG0479@2|Bacteria,1TP8R@1239|Firmicutes,247QI@186801|Clostridia,3Y1ET@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 KKPNOBBG_00969 33035.JPJF01000089_gene108 1.4e-237 652.0 COG1035@1|root,COG4656@1|root,COG1035@2|Bacteria,COG4656@2|Bacteria,1TPBM@1239|Firmicutes,24CJH@186801|Clostridia,3Y13N@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_17,Fer4_8,FrhB_FdhB_C KKPNOBBG_00970 33035.JPJF01000089_gene109 2.02e-106 306.0 COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,3Y10T@572511|Blautia 186801|Clostridia C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - FlpD KKPNOBBG_00971 33035.JPJF01000089_gene110 0.0 1288.0 COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,3Y0ZT@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2 KKPNOBBG_00972 33035.JPJF01000089_gene111 5.43e-91 266.0 COG1150@1|root,COG1150@2|Bacteria,1V27J@1239|Firmicutes,24FU5@186801|Clostridia,3Y1I7@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 KKPNOBBG_00973 33035.JPJF01000089_gene112 5.46e-190 527.0 COG2048@1|root,COG2048@2|Bacteria,1U4JW@1239|Firmicutes,24C8P@186801|Clostridia,3Y1B6@572511|Blautia 186801|Clostridia C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG KKPNOBBG_00974 33035.JPJF01000089_gene113 3.08e-216 598.0 COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3XZ3D@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 ldh - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N KKPNOBBG_00975 33035.JPJF01000089_gene114 0.0 1247.0 COG5002@1|root,COG5002@2|Bacteria,1UM03@1239|Firmicutes,24F2S@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_00976 33035.JPJF01000089_gene115 7.64e-155 436.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3XYV6@572511|Blautia 186801|Clostridia T COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_00977 1195236.CTER_1945 1.71e-58 207.0 COG4219@1|root,COG4219@2|Bacteria,1TQ0K@1239|Firmicutes,24AVI@186801|Clostridia,3WIKG@541000|Ruminococcaceae 186801|Clostridia KT BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M56 KKPNOBBG_00978 180332.JTGN01000003_gene1887 2.42e-53 170.0 COG3682@1|root,COG3682@2|Bacteria,1V7DH@1239|Firmicutes,24JAQ@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - Penicillinase_R KKPNOBBG_00979 33035.JPJF01000032_gene2152 4.29e-81 266.0 COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,3XZ4Y@572511|Blautia 186801|Clostridia M Psort location Extracellular, score - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 KKPNOBBG_00980 1605.Lani381_1291 4.94e-210 588.0 28I8C@1|root,2Z8B6@2|Bacteria,1TQMZ@1239|Firmicutes,4HC3M@91061|Bacilli,3F6AQ@33958|Lactobacillaceae 91061|Bacilli S AIPR protein - - - - - - - - - - - - AIPR KKPNOBBG_00981 556261.HMPREF0240_04472 0.0 2640.0 COG2247@1|root,COG3210@1|root,COG5492@1|root,COG2247@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1TTA4@1239|Firmicutes 1239|Firmicutes U domain, Protein - - - - - - - - - - - - - KKPNOBBG_00988 658086.HMPREF0994_05503 7.7e-104 299.0 COG5586@1|root,COG5586@2|Bacteria,1UY9K@1239|Firmicutes,24G2U@186801|Clostridia,27MGK@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00989 658086.HMPREF0994_05504 3.36e-247 679.0 COG4804@1|root,COG4804@2|Bacteria,1TP7Q@1239|Firmicutes,24A19@186801|Clostridia,27TF6@186928|unclassified Lachnospiraceae 186801|Clostridia S Protein of unknown function (DUF1016) - - - - - - - - - - - - DUF1016 KKPNOBBG_00990 658086.HMPREF0994_05505 4.62e-55 173.0 2B991@1|root,322KC@2|Bacteria,1V7EA@1239|Firmicutes,25CXE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00991 658086.HMPREF0994_05506 6.22e-74 221.0 2DFD5@1|root,2ZRE1@2|Bacteria,1V4FG@1239|Firmicutes,25CTT@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - MobC KKPNOBBG_00992 658086.HMPREF0994_05507 2.13e-188 523.0 COG4227@1|root,COG4227@2|Bacteria,1TRWD@1239|Firmicutes,248KN@186801|Clostridia,27JHN@186928|unclassified Lachnospiraceae 186801|Clostridia L Protein of unknown function (DUF3849) - - - - - - - - - - - - DUF3848,DUF3849 KKPNOBBG_00993 658086.HMPREF0994_05508 0.0 6018.0 COG0249@1|root,COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0249@2|Bacteria,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,2491X@186801|Clostridia,27J19@186928|unclassified Lachnospiraceae 186801|Clostridia KL helicase C-terminal domain protein - - - - - - - - - - - - Helicase_C,MutS_I,N6_Mtase,ResIII,SNF2_N KKPNOBBG_00994 658086.HMPREF0994_05509 2.96e-151 424.0 COG0500@1|root,COG2226@2|Bacteria,1TVU2@1239|Firmicutes,24AIJ@186801|Clostridia,27N1R@186928|unclassified Lachnospiraceae 186801|Clostridia Q O-methyltransferase - - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 KKPNOBBG_00995 658086.HMPREF0994_05510 4.23e-45 145.0 29UA8@1|root,30FKB@2|Bacteria,1UE6G@1239|Firmicutes,253NB@186801|Clostridia,27T37@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00996 658086.HMPREF0994_05511 1.25e-42 139.0 2DP0F@1|root,32UJY@2|Bacteria,1VA60@1239|Firmicutes,24MWB@186801|Clostridia,27P6Z@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative tranposon-transfer assisting protein - - - - - - - - - - - - TTRAP KKPNOBBG_00997 658086.HMPREF0994_05512 0.0 2003.0 COG0358@1|root,COG4227@1|root,COG0358@2|Bacteria,COG4227@2|Bacteria,1TQN4@1239|Firmicutes,2482H@186801|Clostridia,27IQS@186928|unclassified Lachnospiraceae 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - ArdA,DUF4316,Peptidase_M78,YodL,zf-CHC2 KKPNOBBG_00998 658086.HMPREF0994_05513 1.15e-57 179.0 2AFRJ@1|root,315TI@2|Bacteria,1V7X6@1239|Firmicutes,24KY1@186801|Clostridia,27NXW@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_00999 658086.HMPREF0994_05514 0.0 1361.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,27INQ@186928|unclassified Lachnospiraceae 186801|Clostridia L DNA topoisomerase - - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt KKPNOBBG_01000 658086.HMPREF0994_05515 8.03e-159 445.0 28IU3@1|root,2Z8SX@2|Bacteria,1UZB0@1239|Firmicutes,24AJ4@186801|Clostridia,27JHH@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01001 658086.HMPREF0994_05517 7.08e-156 440.0 28HUZ@1|root,2Z81G@2|Bacteria,1TS04@1239|Firmicutes,24AUT@186801|Clostridia,27JU6@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF4366) - - - - - - - - - - - - DUF4366 KKPNOBBG_01002 658086.HMPREF0994_05518 1.44e-47 152.0 2AF03@1|root,314Y6@2|Bacteria,1V9HG@1239|Firmicutes,25CY9@186801|Clostridia,27U7V@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF4315) - - - - - - - - - - - - DUF4315 KKPNOBBG_01003 658086.HMPREF0994_07174 0.0 1111.0 COG0791@1|root,COG0791@2|Bacteria,1TP24@1239|Firmicutes,247K5@186801|Clostridia,27K0V@186928|unclassified Lachnospiraceae 186801|Clostridia M CHAP domain - - - - - - - - - - - - CHAP KKPNOBBG_01004 658086.HMPREF0994_05521 2.45e-86 253.0 2F12W@1|root,33U4C@2|Bacteria,1VUJ7@1239|Firmicutes,2505M@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01005 658086.HMPREF0994_05522 0.0 1593.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,248ND@186801|Clostridia,27IV0@186928|unclassified Lachnospiraceae 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_10 KKPNOBBG_01006 658086.HMPREF0994_05523 3.04e-105 304.0 28PED@1|root,2ZBQF@2|Bacteria,1TT27@1239|Firmicutes,25E4W@186801|Clostridia,27PDM@186928|unclassified Lachnospiraceae 186801|Clostridia S PrgI family protein - - - - - - - - - - - - PrgI KKPNOBBG_01007 658086.HMPREF0994_05524 3.42e-200 555.0 28HUM@1|root,2Z81B@2|Bacteria,1TNZ2@1239|Firmicutes,248SU@186801|Clostridia,27JJK@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_01008 545696.HOLDEFILI_02397 0.0 1189.0 COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,3VP0A@526524|Erysipelotrichia 526524|Erysipelotrichia U Psort location Cytoplasmic, score - - - - - - - - - - - - T4SS-DNA_transf,TraG-D_C KKPNOBBG_01009 658086.HMPREF0994_06320 6.47e-110 317.0 28I1B@1|root,2Z860@2|Bacteria,1TT6W@1239|Firmicutes,24BUI@186801|Clostridia,27TH8@186928|unclassified Lachnospiraceae 186801|Clostridia S Protein of unknown function (DUF3801) - - - - - - - - - - - - DUF3801 KKPNOBBG_01010 658086.HMPREF0994_06321 2.41e-178 496.0 COG3617@1|root,COG3645@1|root,COG3617@2|Bacteria,COG3645@2|Bacteria,1TPKA@1239|Firmicutes,24BSZ@186801|Clostridia,27PMU@186928|unclassified Lachnospiraceae 186801|Clostridia K Phage antirepressor protein KilAC domain - - - - - - - - - - - - ANT,Bro-N KKPNOBBG_01011 658086.HMPREF0994_06322 8.19e-189 526.0 COG3935@1|root,COG3935@2|Bacteria,1TPPF@1239|Firmicutes,249NG@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_36,RepA_N KKPNOBBG_01012 658086.HMPREF0994_06323 1.89e-35 120.0 2E5WX@1|root,330KV@2|Bacteria,1VFRK@1239|Firmicutes,24P0X@186801|Clostridia,27NWE@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01013 658086.HMPREF0994_06324 1.72e-58 181.0 2B1PF@1|root,31U4Y@2|Bacteria,1V8C1@1239|Firmicutes,24K5M@186801|Clostridia,27NK1@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01014 658086.HMPREF0994_06325 5.78e-220 608.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,27J9V@186928|unclassified Lachnospiraceae 186801|Clostridia K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc KKPNOBBG_01015 658086.HMPREF0994_06326 4.65e-190 528.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,247R1@186801|Clostridia,27J85@186928|unclassified Lachnospiraceae 186801|Clostridia D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 KKPNOBBG_01016 537007.BLAHAN_06456 4.81e-81 241.0 COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,3Y045@572511|Blautia 186801|Clostridia J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 KKPNOBBG_01017 33035.JPJF01000019_gene4265 1.18e-98 286.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,3XZVZ@572511|Blautia 186801|Clostridia J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 KKPNOBBG_01018 33035.JPJF01000019_gene4264 0.0 1803.0 COG0627@1|root,COG3250@1|root,COG0627@2|Bacteria,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - - - - - - - - - - - CBM_35,CBM_6,DUF5011,Esterase,F5_F8_type_C,Glyco_hydro_106,Glyco_hydro_76 KKPNOBBG_01019 33035.JPJF01000019_gene4263 6.98e-214 592.0 COG2207@1|root,COG2207@2|Bacteria,1V0IW@1239|Firmicutes,24BME@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_01020 33035.JPJF01000019_gene4262 0.0 1165.0 COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,3XYVS@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - OPT KKPNOBBG_01021 33035.JPJF01000019_gene4261 5.21e-82 242.0 2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,3Y0F4@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PqqD KKPNOBBG_01022 33035.JPJF01000019_gene4260 4.34e-85 253.0 COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,24RKU@186801|Clostridia,3Y0JZ@572511|Blautia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese KKPNOBBG_01023 33035.JPJF01000019_gene4259 9.58e-202 561.0 COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,248J4@186801|Clostridia,3XYUJ@572511|Blautia 186801|Clostridia H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM KKPNOBBG_01024 33035.JPJF01000019_gene4258 1.54e-192 536.0 COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia,3XZQZ@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF2179,YitT_membrane KKPNOBBG_01025 33035.JPJF01000019_gene4257 2.19e-118 339.0 COG3822@1|root,COG3822@2|Bacteria,1V1ZU@1239|Firmicutes,24ENY@186801|Clostridia 186801|Clostridia S ABC-type sugar transport system, auxiliary component - - - - - - - - - - - - Lyx_isomer KKPNOBBG_01026 33035.JPJF01000019_gene4256 0.0 1612.0 COG3250@1|root,COG3250@2|Bacteria,1UZDI@1239|Firmicutes,24C7N@186801|Clostridia 186801|Clostridia G Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_N KKPNOBBG_01027 33035.JPJF01000019_gene4255 6.73e-243 666.0 COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,24ATX@186801|Clostridia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_01028 33035.JPJF01000019_gene4254 6.84e-191 531.0 COG1082@1|root,COG1082@2|Bacteria,1VBV1@1239|Firmicutes,252TF@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_01029 33035.JPJF01000019_gene4253 2.67e-169 475.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3Y2B5@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01030 33035.JPJF01000019_gene4252 1.08e-199 554.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01031 33035.JPJF01000019_gene4251 1.08e-305 837.0 COG1653@1|root,COG1653@2|Bacteria,1TSHR@1239|Firmicutes,24D6W@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_01032 33035.JPJF01000019_gene4250 3.26e-227 627.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,248MY@186801|Clostridia 186801|Clostridia E Alcohol dehydrogenase zinc-binding domain protein - - 1.1.1.287 ko:K17818 ko00040,ko01100,map00040,map01100 - R07143,R07144 RC00102 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_01033 33035.JPJF01000019_gene4249 8.45e-74 222.0 COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,24MPJ@186801|Clostridia,3Y0PG@572511|Blautia 186801|Clostridia G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose rbsD - 5.4.99.62 ko:K06726 ko02010,map02010 - R08247 RC02247 ko00000,ko00001,ko01000 - - - RbsD_FucU KKPNOBBG_01034 33035.JPJF01000019_gene4248 1.23e-184 514.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_01035 33035.JPJF01000019_gene4247 2.29e-230 635.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3Y0AI@572511|Blautia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_01036 33035.JPJF01000019_gene4246 3.52e-274 751.0 COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3Y1MA@572511|Blautia 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK KKPNOBBG_01037 33035.JPJF01000019_gene4245 5.24e-111 321.0 COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,24850@186801|Clostridia,3Y0RJ@572511|Blautia 186801|Clostridia F Phosphoribulokinase / Uridine kinase family udk - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PRK KKPNOBBG_01038 33035.JPJF01000019_gene4244 2.12e-114 329.0 COG0655@1|root,COG0655@2|Bacteria,1TSDE@1239|Firmicutes,24CNT@186801|Clostridia,3XZ9D@572511|Blautia 186801|Clostridia S COG COG0655 Multimeric flavodoxin WrbA - - - - - - - - - - - - FMN_red KKPNOBBG_01039 33035.JPJF01000019_gene4243 0.0 1028.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,3XZKC@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1,Amidohydro_3 KKPNOBBG_01040 33035.JPJF01000019_gene4242 1.85e-300 821.0 COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,3XZ77@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease KKPNOBBG_01041 33035.JPJF01000019_gene4241 1.4e-210 583.0 COG0583@1|root,COG0583@2|Bacteria,1TTAM@1239|Firmicutes,25C6U@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01042 33035.JPJF01000019_gene4240 9.19e-223 617.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_01043 33035.JPJF01000019_gene4239 1.71e-202 564.0 COG1063@1|root,COG1063@2|Bacteria,1VCXY@1239|Firmicutes,24U9W@186801|Clostridia 186801|Clostridia E Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_zinc_N KKPNOBBG_01044 33035.JPJF01000019_gene4238 1.53e-180 506.0 COG1082@1|root,COG1082@2|Bacteria,1UYRD@1239|Firmicutes,2498N@186801|Clostridia 186801|Clostridia G TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_01045 33035.JPJF01000019_gene4237 2.67e-177 497.0 COG1082@1|root,COG1082@2|Bacteria,1UCHD@1239|Firmicutes,24IEY@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_01046 33035.JPJF01000019_gene4236 7.67e-307 844.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_01047 33035.JPJF01000019_gene4235 0.0 1052.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3XZ6E@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_01048 33035.JPJF01000019_gene4234 2.88e-177 496.0 COG0395@1|root,COG0395@2|Bacteria,1V5TP@1239|Firmicutes,24IWF@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01049 33035.JPJF01000019_gene4233 4.66e-200 555.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01050 33035.JPJF01000019_gene4232 2.16e-299 820.0 COG1653@1|root,COG1653@2|Bacteria,1UUUW@1239|Firmicutes,24I2Q@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_01051 33035.JPJF01000019_gene4231 1.81e-154 438.0 COG2110@1|root,COG2110@2|Bacteria,1TQSZ@1239|Firmicutes,24935@186801|Clostridia,3XZYZ@572511|Blautia 186801|Clostridia S phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - - - - - - - - - - Macro KKPNOBBG_01052 33035.JPJF01000019_gene4230 1.64e-193 539.0 COG0846@1|root,COG0846@2|Bacteria,1TQB7@1239|Firmicutes,247UN@186801|Clostridia,3XZV8@572511|Blautia 186801|Clostridia K COG COG0846 NAD-dependent protein deacetylases, SIR2 family - - - - - - - - - - - - - KKPNOBBG_01053 33035.JPJF01000019_gene4228 0.0 1039.0 COG5001@1|root,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - - - - - - - - - - - EAL,GGDEF KKPNOBBG_01054 33035.JPJF01000019_gene4227 5.13e-130 382.0 COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia,3Y16E@572511|Blautia 186801|Clostridia M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1 KKPNOBBG_01055 33035.JPJF01000019_gene4227 7.89e-156 448.0 COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia,3Y16E@572511|Blautia 186801|Clostridia M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1 KKPNOBBG_01056 33035.JPJF01000019_gene4226 2.34e-235 652.0 COG1413@1|root,COG1413@2|Bacteria,1VCSX@1239|Firmicutes,25K0K@186801|Clostridia,3Y1V3@572511|Blautia 186801|Clostridia C lyase activity - - - - - - - - - - - - - KKPNOBBG_01057 33035.JPJF01000019_gene4225 0.0 1371.0 COG0457@1|root,COG0457@2|Bacteria,1TSH7@1239|Firmicutes,248J1@186801|Clostridia,3Y14T@572511|Blautia 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - - KKPNOBBG_01058 33035.JPJF01000019_gene4224 0.0 893.0 COG4935@1|root,COG4935@2|Bacteria,1UI0J@1239|Firmicutes,25E97@186801|Clostridia 186801|Clostridia O CotH kinase protein - - - - - - - - - - - - CotH KKPNOBBG_01059 33035.JPJF01000019_gene4223 2.48e-139 395.0 COG1285@1|root,COG1285@2|Bacteria,1TRUW@1239|Firmicutes,248G4@186801|Clostridia,3Y0H7@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF4956 KKPNOBBG_01060 33035.JPJF01000019_gene4222 3.51e-155 436.0 COG5036@1|root,COG5036@2|Bacteria,1V27Y@1239|Firmicutes,25D4R@186801|Clostridia,3Y0DX@572511|Blautia 186801|Clostridia P VTC domain - - - - - - - - - - - - VTC KKPNOBBG_01061 33035.JPJF01000019_gene4221 4.67e-176 495.0 2CABP@1|root,2Z7KZ@2|Bacteria,1U7V1@1239|Firmicutes,24C2H@186801|Clostridia,3Y1UZ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01062 33035.JPJF01000019_gene4219 4.68e-64 196.0 COG1687@1|root,COG1687@2|Bacteria,1V9YS@1239|Firmicutes,24MSG@186801|Clostridia,3Y1UU@572511|Blautia 186801|Clostridia E Branched-chain amino acid transport protein (AzlD) azlD - - - - - - - - - - - AzlD KKPNOBBG_01063 33035.JPJF01000019_gene4218 3.7e-165 462.0 COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia,3Y0ZX@572511|Blautia 186801|Clostridia E AzlC protein azlC - - - - - - - - - - - AzlC KKPNOBBG_01064 720554.Clocl_1773 1.59e-39 137.0 2EAWX@1|root,334Y4@2|Bacteria,1W6D7@1239|Firmicutes,256RN@186801|Clostridia,3WQUN@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01065 748727.CLJU_c35080 3.81e-33 120.0 COG0454@1|root,COG0456@2|Bacteria,1TUAD@1239|Firmicutes,25KJY@186801|Clostridia,36KK9@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase GNAT family - - - - - - - - - - - - Acetyltransf_7 KKPNOBBG_01066 33035.JPJF01000019_gene4217 2.39e-102 300.0 28MX3@1|root,2ZB49@2|Bacteria,1TT80@1239|Firmicutes,24HRZ@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3795 KKPNOBBG_01067 33035.JPJF01000019_gene4215 9.86e-119 345.0 2CZKX@1|root,32T6M@2|Bacteria,1VCXM@1239|Firmicutes,24PS9@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01068 33035.JPJF01000019_gene4214 2.14e-159 451.0 COG1131@1|root,COG1131@2|Bacteria,1V36A@1239|Firmicutes,24H15@186801|Clostridia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_01069 33035.JPJF01000019_gene4213 1.73e-107 315.0 COG0681@1|root,COG0681@2|Bacteria,1VZKQ@1239|Firmicutes,253YU@186801|Clostridia 186801|Clostridia U Putative zinc-finger - - - - - - - - - - - - zf-HC2 KKPNOBBG_01070 33035.JPJF01000019_gene4212 6.78e-95 279.0 COG1595@1|root,COG1595@2|Bacteria,1VIDJ@1239|Firmicutes,24SAJ@186801|Clostridia 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_01071 33035.JPJF01000019_gene4211 2.98e-90 268.0 COG1396@1|root,COG1396@2|Bacteria,1TQZJ@1239|Firmicutes,25E5Y@186801|Clostridia,3Y0WQ@572511|Blautia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_01072 33035.JPJF01000019_gene4210 2.16e-88 261.0 COG1846@1|root,COG1846@2|Bacteria,1VHM5@1239|Firmicutes,24IJZ@186801|Clostridia 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_01073 1226325.HMPREF1548_01310 4.55e-280 781.0 COG4129@1|root,COG5096@1|root,COG4129@2|Bacteria,COG5096@2|Bacteria,1UI0I@1239|Firmicutes,25E96@186801|Clostridia,36V31@31979|Clostridiaceae 186801|Clostridia U Fusaric acid resistance protein-like - - - - - - - - - - - - FUSC_2 KKPNOBBG_01074 457421.CBFG_00263 1.56e-56 181.0 COG0454@1|root,COG0456@2|Bacteria,1VAAI@1239|Firmicutes,24ID9@186801|Clostridia 186801|Clostridia K COG0454 Histone acetyltransferase HPA2 and related - - - ko:K03827 - - - - ko00000,ko01000 - - - Acetyltransf_10 KKPNOBBG_01075 33035.JPJF01000019_gene4206 0.0 870.0 COG0364@1|root,COG0364@2|Bacteria,1TPYF@1239|Firmicutes,24939@186801|Clostridia 186801|Clostridia G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N KKPNOBBG_01076 33035.JPJF01000019_gene4205 0.0 879.0 COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,248YA@186801|Clostridia,3Y2CG@572511|Blautia 186801|Clostridia G 6-phosphogluconate dehydrogenase, C-terminal domain gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 KKPNOBBG_01077 33035.JPJF01000019_gene4204 1.6e-176 502.0 COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,24DZ9@186801|Clostridia 186801|Clostridia G Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase KKPNOBBG_01078 33035.JPJF01000019_gene4203 3.9e-133 380.0 COG0120@1|root,COG0120@2|Bacteria,1V1DB@1239|Firmicutes,248SF@186801|Clostridia 186801|Clostridia G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A KKPNOBBG_01079 411902.CLOBOL_06110 1.31e-59 186.0 2E64N@1|root,330TH@2|Bacteria,1VF9R@1239|Firmicutes,24JHJ@186801|Clostridia,223P2@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01080 476272.RUMHYD_02319 1.29e-71 216.0 arCOG09714@1|root,316P9@2|Bacteria,1V7WP@1239|Firmicutes,24K29@186801|Clostridia,3Y230@572511|Blautia 186801|Clostridia S COG NOG16854 non supervised orthologous group - - - - - - - - - - - - - KKPNOBBG_01081 445971.ANASTE_01743 3.72e-45 152.0 COG0454@1|root,COG0456@2|Bacteria,1VBM4@1239|Firmicutes,24NCR@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_01082 1123075.AUDP01000022_gene3584 1.7e-61 191.0 COG3603@1|root,COG3603@2|Bacteria,1V9Y8@1239|Firmicutes,24JKN@186801|Clostridia,3WK32@541000|Ruminococcaceae 186801|Clostridia S ACT domain - - - ko:K09707 - - - - ko00000 - - - ACT_7 KKPNOBBG_01083 1321372.AQQB01000003_gene1481 6.8e-97 285.0 COG0645@1|root,COG0645@2|Bacteria,1TSSD@1239|Firmicutes,4IJ7S@91061|Bacilli,1WTVK@1307|Streptococcus suis 91061|Bacilli S Chloramphenicol phosphotransferase-like protein - - - - - - - - - - - - AAA_18 KKPNOBBG_01084 411468.CLOSCI_02790 7.3e-74 223.0 COG3708@1|root,COG3708@2|Bacteria,1V51M@1239|Firmicutes,24IWT@186801|Clostridia,2205B@1506553|Lachnoclostridium 186801|Clostridia K Protein of unknown function (DUF3788) - - - - - - - - - - - - DUF3788 KKPNOBBG_01085 742740.HMPREF9474_01246 5.72e-78 233.0 2DH26@1|root,2ZY4Z@2|Bacteria,1V3J9@1239|Firmicutes,24HRK@186801|Clostridia,222SR@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF3795) - - - - - - - - - - - - DUF3795 KKPNOBBG_01086 742740.HMPREF9474_01180 1.42e-147 419.0 COG0596@1|root,COG0596@2|Bacteria,1TSPF@1239|Firmicutes,24AD1@186801|Clostridia,222JG@1506553|Lachnoclostridium 186801|Clostridia S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 KKPNOBBG_01088 33035.JPJF01000068_gene4514 4.88e-311 850.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3XZ3E@572511|Blautia 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr KKPNOBBG_01089 33035.JPJF01000068_gene4513 5.45e-231 635.0 COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia,3XZA2@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yhaM - - ko:K03698 - - - - ko00000,ko01000,ko03019 - - - HD,tRNA_anti-codon KKPNOBBG_01090 33035.JPJF01000068_gene4512 3.25e-280 771.0 COG0265@1|root,COG0265@2|Bacteria,1TTAZ@1239|Firmicutes,24BWH@186801|Clostridia,3XZG2@572511|Blautia 186801|Clostridia O COG COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 KKPNOBBG_01091 33035.JPJF01000068_gene4511 0.0 1392.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,3XYKH@572511|Blautia 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr KKPNOBBG_01092 33035.JPJF01000068_gene4510 8.73e-171 476.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3XZ5B@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01093 33035.JPJF01000068_gene4509 0.0 878.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3XZ8I@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_01094 33035.JPJF01000068_gene4508 7.6e-118 337.0 COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,3XYZI@572511|Blautia 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase KKPNOBBG_01095 33035.JPJF01000068_gene4507 1.01e-228 630.0 COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3XZIN@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C KKPNOBBG_01097 33035.JPJF01000068_gene4505 1.96e-139 398.0 COG2176@1|root,COG2176@2|Bacteria,1V3E4@1239|Firmicutes,249X5@186801|Clostridia,3XZPP@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T KKPNOBBG_01098 33035.JPJF01000068_gene4504 7.77e-149 419.0 COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,3XZHD@572511|Blautia 186801|Clostridia L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD KKPNOBBG_01099 33035.JPJF01000068_gene4503 0.0 1050.0 COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,3XZA6@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - 1.21.98.3 ko:K04034 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R06268,R06269,R06270 RC00741,RC01491,RC01492 ko00000,ko00001,ko01000 - - - B12-binding,DUF4080,Radical_SAM KKPNOBBG_01101 33035.JPJF01000068_gene4501 0.0 1223.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3Y14U@572511|Blautia 186801|Clostridia P Signal recognition particle receptor beta subunit - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate KKPNOBBG_01102 33035.JPJF01000068_gene4500 4.77e-42 138.0 COG1918@1|root,COG1918@2|Bacteria,1VKST@1239|Firmicutes,24UDC@186801|Clostridia 186801|Clostridia P FeoA domain - - - - - - - - - - - - FeoA KKPNOBBG_01103 33035.JPJF01000068_gene4499 2.7e-268 739.0 COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,3XZ6K@572511|Blautia 186801|Clostridia P Sodium/hydrogen exchanger family napA - - - - - - - - - - - Na_H_Exchanger KKPNOBBG_01104 33035.JPJF01000068_gene4498 0.0 1426.0 COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3XYTU@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,NRDD KKPNOBBG_01105 33035.JPJF01000068_gene4497 8.62e-287 787.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZ7G@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_01106 33035.JPJF01000068_gene4496 2e-198 552.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,3XZFN@572511|Blautia 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase KKPNOBBG_01107 33035.JPJF01000068_gene4495 2.8e-229 631.0 COG2221@1|root,COG2221@2|Bacteria,1UI1A@1239|Firmicutes,25EAA@186801|Clostridia,3Y28E@572511|Blautia 186801|Clostridia C Nitrite and sulphite reductase 4Fe-4S domain dsvA - - - - - - - - - - - C_GCAxxG_C_C,Fer4,Fer4_10,NIR_SIR,NIR_SIR_ferr KKPNOBBG_01108 33035.JPJF01000068_gene4494 0.0 1011.0 COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,3XZD7@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese KKPNOBBG_01109 33035.JPJF01000068_gene4493 3.84e-206 572.0 COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,3XZ9Y@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01110 500632.CLONEX_03862 1.41e-33 115.0 COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia 186801|Clostridia C rubredoxin rd - - - - - - - - - - - Rubredoxin KKPNOBBG_01111 33035.JPJF01000068_gene4491 1.27e-104 303.0 2BRC2@1|root,32KAP@2|Bacteria,1V6Y3@1239|Firmicutes,24KI1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01112 33035.JPJF01000068_gene4490 0.0 978.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia 186801|Clostridia C Na H antiporter nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter KKPNOBBG_01113 33035.JPJF01000068_gene4489 0.0 972.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,3Y1C9@572511|Blautia 186801|Clostridia E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic KKPNOBBG_01114 33035.JPJF01000068_gene4488 0.0 1865.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,3Y13S@572511|Blautia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C KKPNOBBG_01115 33035.JPJF01000068_gene4487 3.11e-140 398.0 COG0664@1|root,COG0664@2|Bacteria,1VCZE@1239|Firmicutes,24PP3@186801|Clostridia 186801|Clostridia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding KKPNOBBG_01116 742733.HMPREF9469_02275 1.18e-22 93.6 2DSCR@1|root,33FK0@2|Bacteria,1VKCD@1239|Firmicutes,24QWS@186801|Clostridia,22085@1506553|Lachnoclostridium 186801|Clostridia S Domain of unknown function (DUF3783) - - - - - - - - - - - - DUF3783 KKPNOBBG_01117 33035.JPJF01000068_gene4484 0.0 1174.0 COG3533@1|root,COG3533@2|Bacteria,1TRV9@1239|Firmicutes,24CKP@186801|Clostridia 186801|Clostridia G Beta-L-arabinofuranosidase, GH127 - - - - - - - - - - - - Glyco_hydro_127 KKPNOBBG_01118 33035.JPJF01000068_gene4483 5.89e-180 502.0 COG0395@1|root,COG0395@2|Bacteria,1V6WK@1239|Firmicutes,24MD8@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01119 33035.JPJF01000068_gene4482 8.69e-178 497.0 COG1175@1|root,COG1175@2|Bacteria,1V05I@1239|Firmicutes,24D4P@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01120 33035.JPJF01000068_gene4481 6.64e-297 811.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,3Y14V@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01121 33035.JPJF01000068_gene4480 3.73e-208 576.0 COG2207@1|root,COG2207@2|Bacteria,1UUVG@1239|Firmicutes,24SJE@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_01122 33035.JPJF01000068_gene4479 7.71e-250 692.0 COG2271@1|root,COG2271@2|Bacteria,1V0WU@1239|Firmicutes,25E6S@186801|Clostridia 186801|Clostridia G PFAM Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 KKPNOBBG_01123 33035.JPJF01000068_gene4478 3.75e-193 537.0 COG0191@1|root,COG0191@2|Bacteria,1TRS4@1239|Firmicutes,24CD4@186801|Clostridia,3Y1PV@572511|Blautia 186801|Clostridia G Fructose-bisphosphate aldolase class-II iolJ - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase KKPNOBBG_01124 33035.JPJF01000146_gene2134 1.75e-252 698.0 COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,2483N@186801|Clostridia,3Y0Z3@572511|Blautia 186801|Clostridia P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 KKPNOBBG_01125 33035.JPJF01000146_gene2135 1.26e-168 472.0 COG1349@1|root,COG1349@2|Bacteria,1TTGR@1239|Firmicutes,25C4C@186801|Clostridia 186801|Clostridia K transcriptional regulator iolR - - ko:K06608 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_01126 1232447.BAHW02000038_gene2607 1.6e-56 183.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_01127 33035.JPJF01000042_gene361 4.08e-289 789.0 COG0675@1|root,COG0675@2|Bacteria,1TT7D@1239|Firmicutes,24EJK@186801|Clostridia,3Y163@572511|Blautia 186801|Clostridia L Putative transposase DNA-binding domain - - - - - - - - - - - - OrfB_Zn_ribbon KKPNOBBG_01128 33035.JPJF01000065_gene5077 1.75e-256 705.0 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24B23@186801|Clostridia,3Y00V@572511|Blautia 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_01129 33035.JPJF01000013_gene4532 3.5e-307 840.0 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,3XZFT@572511|Blautia 186801|Clostridia M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M KKPNOBBG_01130 33035.JPJF01000013_gene4533 2.34e-241 664.0 COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,3XYIN@572511|Blautia 186801|Clostridia M Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N KKPNOBBG_01131 33035.JPJF01000013_gene4534 2.29e-200 556.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_01132 33035.JPJF01000013_gene4535 0.0 2184.0 COG1196@1|root,COG2273@1|root,COG5263@1|root,COG1196@2|Bacteria,COG2273@2|Bacteria,COG5263@2|Bacteria,1UUUJ@1239|Firmicutes,25KCI@186801|Clostridia,3Y1HA@572511|Blautia 186801|Clostridia G Putative cell wall binding repeat - - 3.2.1.35 ko:K01197 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 - ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - - - CW_binding_1,F5_F8_type_C KKPNOBBG_01133 33035.JPJF01000013_gene4536 0.0 921.0 COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,3XYNG@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - PG_binding_4,YkuD KKPNOBBG_01134 33035.JPJF01000013_gene4537 8.36e-308 840.0 COG1167@1|root,COG1167@2|Bacteria,1TPMY@1239|Firmicutes,24986@186801|Clostridia,3XZB7@572511|Blautia 186801|Clostridia EK Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Aminotran_MocR KKPNOBBG_01135 33035.JPJF01000013_gene4538 0.0 1574.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3XZ58@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase KKPNOBBG_01136 33035.JPJF01000013_gene4539 2.45e-213 588.0 COG1092@1|root,COG1092@2|Bacteria,1TPUD@1239|Firmicutes,2480X@186801|Clostridia,3XYN6@572511|Blautia 186801|Clostridia H S-adenosylmethionine-dependent methyltransferase rlmL_1 - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM KKPNOBBG_01137 33035.JPJF01000013_gene4545 3.45e-79 244.0 COG3212@1|root,COG3212@2|Bacteria,1VCWB@1239|Firmicutes,24NZX@186801|Clostridia,3Y0I3@572511|Blautia 186801|Clostridia S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY KKPNOBBG_01138 33035.JPJF01000013_gene4546 2.42e-263 729.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia,3XZDQ@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_01139 33035.JPJF01000013_gene4547 3.81e-151 426.0 COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,3XYM2@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.55 mprA - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01140 33035.JPJF01000013_gene4548 7.36e-55 171.0 COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,3Y0K2@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1294 KKPNOBBG_01141 33035.JPJF01000013_gene4549 4.32e-234 645.0 COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,3XZG1@572511|Blautia 186801|Clostridia EJ Psort location Cytoplasmic, score ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase KKPNOBBG_01142 33035.JPJF01000013_gene4550 4.56e-247 680.0 COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,3XZ4P@572511|Blautia 186801|Clostridia E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt KKPNOBBG_01143 33035.JPJF01000013_gene4551 6.85e-165 461.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3XYJK@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 vanR3 - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01144 33035.JPJF01000013_gene4552 0.0 1350.0 COG0642@1|root,COG2205@2|Bacteria,1TP73@1239|Firmicutes,248Y6@186801|Clostridia,3XZAZ@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01145 33035.JPJF01000013_gene4553 0.0 1300.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,24FH0@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_01146 33035.JPJF01000013_gene4554 3.48e-184 514.0 COG0395@1|root,COG0395@2|Bacteria,1UXJD@1239|Firmicutes,25M52@186801|Clostridia,3Y1KD@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01147 33035.JPJF01000013_gene4555 1.51e-183 513.0 COG1175@1|root,COG1175@2|Bacteria,1UXJE@1239|Firmicutes,25MIM@186801|Clostridia,3Y1QD@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01148 33035.JPJF01000013_gene4556 4.53e-266 735.0 COG1653@1|root,COG1653@2|Bacteria,1UUUK@1239|Firmicutes,25MFP@186801|Clostridia,3Y1WB@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 KKPNOBBG_01149 1226325.HMPREF1548_06731 8.37e-295 812.0 COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,36DY3@31979|Clostridiaceae 186801|Clostridia G Alpha-L-arabinofuranosidase - - - - - - - - - - - - Alpha-L-AF_C,Laminin_G_3 KKPNOBBG_01150 33035.JPJF01000013_gene4557 0.0 1051.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3Y1IV@572511|Blautia 186801|Clostridia T Cache domain - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_01151 33035.JPJF01000013_gene4558 0.0 925.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3Y1R1@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_01152 33035.JPJF01000013_gene4559 4.24e-196 546.0 COG0679@1|root,COG0679@2|Bacteria,1V0ZS@1239|Firmicutes,24CQ0@186801|Clostridia 186801|Clostridia S PFAM Auxin Efflux Carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans KKPNOBBG_01153 33035.JPJF01000141_gene2442 2.58e-157 448.0 28M3R@1|root,2ZAHU@2|Bacteria,1TR3Y@1239|Firmicutes,249MC@186801|Clostridia,3XZ6X@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01154 33035.JPJF01000013_gene4560 5.11e-109 316.0 COG1335@1|root,COG1335@2|Bacteria,1V1CY@1239|Firmicutes,24HQM@186801|Clostridia,3Y05Q@572511|Blautia 186801|Clostridia Q Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Isochorismatase KKPNOBBG_01155 33035.JPJF01000013_gene4561 5.11e-244 672.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,3Y104@572511|Blautia 186801|Clostridia C Acetokinase family buk - 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase KKPNOBBG_01156 33035.JPJF01000013_gene4562 5.55e-121 348.0 COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3XZ6F@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - AATase KKPNOBBG_01157 33035.JPJF01000013_gene4563 1.02e-297 813.0 COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3XZ6F@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - AATase KKPNOBBG_01158 33035.JPJF01000013_gene4564 2.41e-231 637.0 COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,249GM@186801|Clostridia,3XZT2@572511|Blautia 186801|Clostridia I Steryl acetyl hydrolase - - - - - - - - - - - - Abhydrolase_3 KKPNOBBG_01159 33035.JPJF01000013_gene4565 4.66e-128 363.0 COG5423@1|root,COG5423@2|Bacteria,1V8Y4@1239|Firmicutes,24EAF@186801|Clostridia 186801|Clostridia S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 KKPNOBBG_01160 33035.JPJF01000013_gene4579 1.45e-124 357.0 COG3544@1|root,COG3544@2|Bacteria,1V6WE@1239|Firmicutes,24KNZ@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 KKPNOBBG_01162 1144313.PMI10_03911 1.93e-171 528.0 COG3507@1|root,COG3507@2|Bacteria,4NIWC@976|Bacteroidetes,1I7FA@117743|Flavobacteriia,2NV36@237|Flavobacterium 976|Bacteroidetes G Pfam Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 KKPNOBBG_01163 33035.JPJF01000083_gene5130 1.12e-174 489.0 COG0395@1|root,COG0395@2|Bacteria,1TSGI@1239|Firmicutes,24BDH@186801|Clostridia,3XZD9@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K10190 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_01164 33035.JPJF01000083_gene5131 3.42e-194 540.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia,3XYXH@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10189 ko02010,map02010 M00199,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_01165 33035.JPJF01000083_gene5132 1.1e-229 643.0 COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia,3XZJC@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein lacE - - ko:K10188 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01166 1392490.JHZX01000001_gene723 5.67e-56 194.0 COG2017@1|root,COG2017@2|Bacteria,4NF5G@976|Bacteroidetes,1HZCR@117743|Flavobacteriia 976|Bacteroidetes G Converts alpha-aldose to the beta-anomer - - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim KKPNOBBG_01167 33035.JPJF01000061_gene3666 2.36e-315 879.0 COG1874@1|root,COG1874@2|Bacteria,1TSHK@1239|Firmicutes,249IJ@186801|Clostridia 186801|Clostridia G beta-galactosidase - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_35,Glyco_hydro_98M,NPCBM KKPNOBBG_01169 1449050.JNLE01000003_gene3487 1.33e-160 455.0 COG2207@1|root,COG2207@2|Bacteria,1TS5C@1239|Firmicutes,24EJH@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_01170 1449050.JNLE01000003_gene3488 0.0 1623.0 COG0457@1|root,COG0457@2|Bacteria,1TPP8@1239|Firmicutes,24B55@186801|Clostridia,36G25@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107,TPR_12,TPR_16,TPR_2,TPR_8 KKPNOBBG_01172 33035.JPJF01000013_gene4586 0.0 1032.0 COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,3Y0FH@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score 9.99 cstA - - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM KKPNOBBG_01173 33035.JPJF01000013_gene4587 4.92e-110 318.0 2DMWJ@1|root,32U4E@2|Bacteria,1VH8Q@1239|Firmicutes,25HNA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01174 33035.JPJF01000013_gene4588 4.95e-77 232.0 COG3467@1|root,COG3467@2|Bacteria,1UUUN@1239|Firmicutes,25KCK@186801|Clostridia,3Y1RN@572511|Blautia 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Pyridox_ox_2 KKPNOBBG_01175 33035.JPJF01000013_gene4595 0.0 987.0 COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,3XZ89@572511|Blautia 186801|Clostridia C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane KKPNOBBG_01176 33035.JPJF01000013_gene4596 7.92e-96 282.0 COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,3XZ8P@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Fer4,Fer4_6 KKPNOBBG_01177 33035.JPJF01000013_gene4597 4.46e-148 417.0 COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,3XZ4Z@572511|Blautia 186801|Clostridia K COG COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - HTH_Crp_2,cNMP_binding KKPNOBBG_01178 33035.JPJF01000013_gene4598 1.37e-251 691.0 COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia 186801|Clostridia E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - Radical_SAM KKPNOBBG_01179 1232453.BAIF02000054_gene1190 2.8e-65 202.0 COG0454@1|root,COG0456@2|Bacteria,1VBFC@1239|Firmicutes,24KAJ@186801|Clostridia,26B8J@186813|unclassified Clostridiales 186801|Clostridia K FR47-like protein bltD - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 KKPNOBBG_01180 33035.JPJF01000013_gene4599 1.44e-140 398.0 COG0454@1|root,COG0456@2|Bacteria,1V1TW@1239|Firmicutes,24HI4@186801|Clostridia,3Y026@572511|Blautia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 KKPNOBBG_01181 33035.JPJF01000013_gene4600 9.52e-164 460.0 COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,24BUT@186801|Clostridia,3Y0EV@572511|Blautia 186801|Clostridia K TipAS antibiotic-recognition domain - - - - - - - - - - - - MerR_1,TipAS KKPNOBBG_01182 33035.JPJF01000013_gene4601 2.95e-286 786.0 COG2211@1|root,COG2211@2|Bacteria,1V65Z@1239|Firmicutes,24ISG@186801|Clostridia 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 KKPNOBBG_01183 33035.JPJF01000013_gene4603 1.86e-215 595.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3XZPJ@572511|Blautia 186801|Clostridia G COG COG0191 Fructose tagatose bisphosphate aldolase fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase KKPNOBBG_01184 33035.JPJF01000013_gene4604 2e-284 778.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,3XYJB@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK KKPNOBBG_01185 33035.JPJF01000013_gene4605 1.73e-97 283.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3XZXS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 rpiB - - - - - - - - - - - LacAB_rpiB KKPNOBBG_01186 33035.JPJF01000013_gene4606 2.76e-162 455.0 COG2186@1|root,COG2186@2|Bacteria,1V3VZ@1239|Firmicutes,25MUE@186801|Clostridia,3Y1KV@572511|Blautia 186801|Clostridia K FCD domain - - - - - - - - - - - - FCD,GntR KKPNOBBG_01187 33035.JPJF01000013_gene4607 3.35e-168 471.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 KKPNOBBG_01188 33035.JPJF01000013_gene4608 2.72e-216 598.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3Y108@572511|Blautia 186801|Clostridia G Transketolase, pyrimidine binding domain - - - - - - - - - - - - Transket_pyr,Transketolase_C KKPNOBBG_01189 33035.JPJF01000013_gene4609 2.34e-205 568.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3Y1BE@572511|Blautia 186801|Clostridia G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N KKPNOBBG_01190 33035.JPJF01000013_gene4610 3.05e-268 739.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,3XZAD@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DctM KKPNOBBG_01191 33035.JPJF01000013_gene4611 1.61e-102 297.0 COG3090@1|root,COG3090@2|Bacteria,1V6P9@1239|Firmicutes,24JKS@186801|Clostridia,3XZTR@572511|Blautia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ KKPNOBBG_01192 33035.JPJF01000013_gene4612 2.15e-230 637.0 COG1638@1|root,COG1638@2|Bacteria,1UCYF@1239|Firmicutes,25B11@186801|Clostridia,3Y2DS@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_01193 33035.JPJF01000013_gene4613 6.04e-97 287.0 COG5660@1|root,COG5660@2|Bacteria,1VKXY@1239|Firmicutes,24UK9@186801|Clostridia,3Y0RV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - zf-HC2 KKPNOBBG_01194 33035.JPJF01000013_gene4614 1.12e-99 290.0 COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,25B12@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_01195 33035.JPJF01000013_gene4615 0.0 1389.0 COG0577@1|root,COG0577@2|Bacteria,1V0HA@1239|Firmicutes,24AID@186801|Clostridia,3XYH2@572511|Blautia 186801|Clostridia V COG COG0577 ABC-type antimicrobial peptide transport system, permease component - - - - - - - - - - - - FtsX KKPNOBBG_01196 33035.JPJF01000013_gene4616 2.62e-144 410.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,24BG4@186801|Clostridia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_01197 33035.JPJF01000013_gene4617 2e-190 533.0 COG0642@1|root,COG2205@2|Bacteria,1TR7T@1239|Firmicutes,25B13@186801|Clostridia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01198 33035.JPJF01000013_gene4618 1.17e-144 409.0 COG0745@1|root,COG0745@2|Bacteria,1V0KW@1239|Firmicutes,24E9Z@186801|Clostridia,3Y066@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01199 33035.JPJF01000013_gene4619 3.25e-282 777.0 COG0642@1|root,COG2205@2|Bacteria,1TRAB@1239|Firmicutes,24DV3@186801|Clostridia,3Y1EV@572511|Blautia 186801|Clostridia T Domain of unknown function (DUF4173) - - - - - - - - - - - - DUF4173 KKPNOBBG_01200 33035.JPJF01000013_gene4620 5.49e-38 127.0 COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,3Y0N1@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 KKPNOBBG_01201 33035.JPJF01000013_gene4621 5.48e-98 286.0 2AKH0@1|root,31B8X@2|Bacteria,1V6ZY@1239|Firmicutes,24JGF@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF2975) - - - - - - - - - - - - DUF2975 KKPNOBBG_01203 33035.JPJF01000013_gene4622 4.44e-105 306.0 COG1247@1|root,COG1247@2|Bacteria,1V3XH@1239|Firmicutes,24HCN@186801|Clostridia,3Y0EN@572511|Blautia 186801|Clostridia M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_01204 33035.JPJF01000013_gene4623 2.79e-106 320.0 COG3064@1|root,COG3064@2|Bacteria 2|Bacteria M translation initiation factor activity cbpA - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - CW_binding_1,RICH,SNase,YSIRK_signal KKPNOBBG_01205 33035.JPJF01000013_gene4624 4.83e-102 296.0 COG1329@1|root,COG1329@2|Bacteria,1VAA0@1239|Firmicutes,24P60@186801|Clostridia,3Y0SQ@572511|Blautia 186801|Clostridia K CarD-like/TRCF domain - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF KKPNOBBG_01206 1123075.AUDP01000002_gene3470 1.19e-81 248.0 COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249VD@186801|Clostridia,3WJ6J@541000|Ruminococcaceae 186801|Clostridia F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_01207 545697.HMPREF0216_02461 4.33e-216 610.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia,36VMU@31979|Clostridiaceae 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_01208 33035.JPJF01000013_gene4625 9.69e-275 749.0 COG0407@1|root,COG0407@2|Bacteria,1VQWJ@1239|Firmicutes,24YE8@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01209 33035.JPJF01000013_gene4626 2.58e-211 587.0 COG1609@1|root,COG1609@2|Bacteria,1TPZJ@1239|Firmicutes,248K0@186801|Clostridia,3Y29Y@572511|Blautia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_01210 33035.JPJF01000013_gene4627 3e-176 495.0 COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,3XZ7M@572511|Blautia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_01211 33035.JPJF01000013_gene4628 7.62e-228 630.0 COG1363@1|root,COG1363@2|Bacteria,1TS74@1239|Firmicutes,25CDG@186801|Clostridia 186801|Clostridia G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 KKPNOBBG_01212 33035.JPJF01000013_gene4629 2.86e-305 835.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE KKPNOBBG_01213 33035.JPJF01000013_gene4630 1.16e-303 828.0 COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia,3XZJC@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_01214 33035.JPJF01000013_gene4631 2.58e-190 529.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,3Y0FC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01215 33035.JPJF01000013_gene4632 3.58e-208 576.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia,3XYXH@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10189 ko02010,map02010 M00199,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_01216 33035.JPJF01000013_gene4633 0.0 1905.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,3XYIU@572511|Blautia 186801|Clostridia G Beta galactosidase small chain - - - - - - - - - - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_01217 33035.JPJF01000013_gene4634 1.19e-233 644.0 COG1609@1|root,COG1609@2|Bacteria,1UK1H@1239|Firmicutes,249XN@186801|Clostridia,3XZFY@572511|Blautia 1239|Firmicutes K Psort location Cytoplasmic, score 9.98 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_01218 33035.JPJF01000013_gene4635 1.76e-222 615.0 COG2222@1|root,COG2222@2|Bacteria,1VQYP@1239|Firmicutes,24YUI@186801|Clostridia 186801|Clostridia M SIS domain - - - - - - - - - - - - SIS KKPNOBBG_01219 33035.JPJF01000013_gene4636 7.34e-116 336.0 COG2188@1|root,COG2188@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_01220 33035.JPJF01000013_gene4637 1.16e-167 470.0 COG0524@1|root,COG0524@2|Bacteria,1TSA3@1239|Firmicutes,24CDF@186801|Clostridia,3Y0FA@572511|Blautia 186801|Clostridia G COG COG0524 Sugar kinases, ribokinase family - - 2.7.1.218 ko:K10710 - - R08124 RC00002,RC00017 ko00000,ko01000 - - - PfkB KKPNOBBG_01221 33035.JPJF01000013_gene4638 3.04e-110 323.0 COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,24N1N@186801|Clostridia,3Y0MI@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_01222 33035.JPJF01000013_gene4639 5.47e-44 154.0 2C7NE@1|root,348SX@2|Bacteria,1VZZ3@1239|Firmicutes,254BH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01224 33035.JPJF01000013_gene4642 2.6e-216 606.0 COG0772@1|root,COG0772@2|Bacteria,1TRIP@1239|Firmicutes,258QF@186801|Clostridia,3Y1Z2@572511|Blautia 186801|Clostridia D Belongs to the SEDS family - - - - - - - - - - - - - KKPNOBBG_01225 33035.JPJF01000013_gene4643 2.15e-75 225.0 COG1695@1|root,COG1695@2|Bacteria,1VAKA@1239|Firmicutes,24MVF@186801|Clostridia,3Y1TV@572511|Blautia 186801|Clostridia K Transcriptional regulator PadR-like family - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR KKPNOBBG_01226 33035.JPJF01000013_gene4644 5.48e-25 94.4 2CDEN@1|root,2ZUAD@2|Bacteria,1W2UE@1239|Firmicutes,2569U@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01227 33035.JPJF01000013_gene4645 5.04e-180 506.0 COG2207@1|root,COG2207@2|Bacteria,1VT0T@1239|Firmicutes,24YTA@186801|Clostridia,3Y0YN@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_01228 33035.JPJF01000013_gene4646 8.22e-273 751.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZ7G@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_01229 33035.JPJF01000013_gene4647 4.52e-101 298.0 COG0110@1|root,COG0110@2|Bacteria 2|Bacteria S O-acyltransferase activity lacA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008374,GO:0008870,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0042802,GO:0044424,GO:0044464 2.3.1.18,2.3.1.79 ko:K00633,ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_01230 33035.JPJF01000013_gene4648 2.51e-175 498.0 2E1BR@1|root,32WRK@2|Bacteria,1V7RQ@1239|Firmicutes 1239|Firmicutes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MacB_PCD KKPNOBBG_01231 33035.JPJF01000013_gene4649 8.33e-186 536.0 COG0845@1|root,COG0845@2|Bacteria,1V7WB@1239|Firmicutes,24CBF@186801|Clostridia 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 KKPNOBBG_01232 33035.JPJF01000013_gene4650 7.92e-186 518.0 COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,2488S@186801|Clostridia,3XYW1@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01233 33035.JPJF01000013_gene4651 1.3e-176 494.0 COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,3Y0K9@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01234 33035.JPJF01000013_gene4652 0.0 1144.0 COG1653@1|root,COG1653@2|Bacteria,1V540@1239|Firmicutes,25B14@186801|Clostridia 186801|Clostridia G transport - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01235 33035.JPJF01000013_gene4653 2.82e-153 431.0 COG0745@1|root,COG0745@2|Bacteria,1UZIS@1239|Firmicutes,24CCE@186801|Clostridia,3XYX9@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01236 33035.JPJF01000013_gene4654 1.2e-252 700.0 COG0642@1|root,COG2205@2|Bacteria,1UWJ3@1239|Firmicutes,25E8T@186801|Clostridia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01237 33035.JPJF01000013_gene4659 1.3e-130 371.0 COG2818@1|root,COG2818@2|Bacteria,1UZRT@1239|Firmicutes,25B15@186801|Clostridia 186801|Clostridia L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco KKPNOBBG_01239 33035.JPJF01000013_gene4666 1.23e-192 538.0 COG5660@1|root,COG5660@2|Bacteria,1VKXY@1239|Firmicutes,24UK9@186801|Clostridia,3Y0RV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - zf-HC2 KKPNOBBG_01240 33035.JPJF01000013_gene4667 2.91e-109 314.0 COG1595@1|root,COG1595@2|Bacteria,1V8GV@1239|Firmicutes,24JEH@186801|Clostridia,3Y2C1@572511|Blautia 186801|Clostridia K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_01241 33035.JPJF01000013_gene4669 0.0 1101.0 COG0577@1|root,COG0577@2|Bacteria,1TSMB@1239|Firmicutes,24ABI@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_01242 33035.JPJF01000013_gene4670 2.01e-164 461.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia 186801|Clostridia V ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01243 33035.JPJF01000013_gene4671 3.76e-135 386.0 COG3279@1|root,COG3279@2|Bacteria,1UUUP@1239|Firmicutes,25B16@186801|Clostridia 186801|Clostridia T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_01244 33035.JPJF01000013_gene4672 1.11e-260 720.0 COG3290@1|root,COG3290@2|Bacteria,1UI03@1239|Firmicutes,25E8U@186801|Clostridia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_01245 33035.JPJF01000013_gene4673 0.0 1347.0 COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,248SQ@186801|Clostridia,3Y1H2@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - - - - - - - - - - FtsX KKPNOBBG_01246 33035.JPJF01000013_gene4674 3.62e-145 410.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XZQT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - - - - - - - - - - ABC_tran KKPNOBBG_01247 33035.JPJF01000013_gene4675 1.64e-178 501.0 COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01248 33035.JPJF01000013_gene4676 4.96e-148 418.0 COG0745@1|root,COG0745@2|Bacteria,1TSNV@1239|Firmicutes,2493A@186801|Clostridia,3Y04C@572511|Blautia 186801|Clostridia KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01249 742723.HMPREF9477_01743 1.78e-13 71.2 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia,27UB2@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01250 33035.JPJF01000035_gene3478 3.92e-306 835.0 COG1653@1|root,COG1653@2|Bacteria,1UZFS@1239|Firmicutes 1239|Firmicutes G Bacterial extracellular solute-binding protein - - - ko:K02027,ko:K10117 ko02010,map02010 M00196,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01251 33035.JPJF01000035_gene3479 0.0 964.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3XZ1E@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01252 33035.JPJF01000035_gene3480 0.0 1106.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,25KCW@186801|Clostridia,3Y11X@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - His_kinase KKPNOBBG_01253 33035.JPJF01000035_gene3481 1.21e-297 815.0 COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,24K16@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01254 1163671.JAGI01000003_gene809 9.08e-129 389.0 COG2199@1|root,COG2199@2|Bacteria,1TQ2X@1239|Firmicutes,25E4G@186801|Clostridia,36EDI@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GAF,GAF_2,GAF_3,GGDEF KKPNOBBG_01255 33035.JPJF01000035_gene3482 1.46e-170 481.0 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia 186801|Clostridia EG metabolite transporter - - - - - - - - - - - - EamA KKPNOBBG_01257 411902.CLOBOL_07347 6.11e-58 191.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24C2K@186801|Clostridia,2206K@1506553|Lachnoclostridium 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_01259 180332.JTGN01000013_gene866 7.16e-172 511.0 COG5002@1|root,COG5002@2|Bacteria,1UINY@1239|Firmicutes,25EPM@186801|Clostridia 186801|Clostridia T ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_01260 33035.JPJF01000035_gene3484 1.49e-116 334.0 COG1443@1|root,COG1443@2|Bacteria,1V6SB@1239|Firmicutes,24HX1@186801|Clostridia 186801|Clostridia I Hydrolase, nudix family - - - - - - - - - - - - NUDIX KKPNOBBG_01261 33035.JPJF01000035_gene3485 0.0 1350.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3XYX5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_01262 180332.JTGN01000002_gene5661 2.98e-180 528.0 COG2972@1|root,COG2972@2|Bacteria,1V4G9@1239|Firmicutes,24IA9@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase KKPNOBBG_01263 180332.JTGN01000002_gene5660 2.38e-101 304.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V27N@1239|Firmicutes,24EUU@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_01264 180332.JTGN01000002_gene5659 6.65e-111 328.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_01265 180332.JTGN01000002_gene5658 1.25e-172 486.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_01266 180332.JTGN01000002_gene5657 3.25e-186 533.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01267 33035.JPJF01000035_gene3486 2.11e-157 441.0 2DRRG@1|root,32URH@2|Bacteria,1VCR2@1239|Firmicutes,24PBW@186801|Clostridia,3Y1I6@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01268 33035.JPJF01000035_gene3487 3.65e-164 462.0 COG0253@1|root,COG0253@2|Bacteria,1V77F@1239|Firmicutes,24H7N@186801|Clostridia,3Y18W@572511|Blautia 186801|Clostridia E COG0253 Diaminopimelate epimerase - - - - - - - - - - - - - KKPNOBBG_01269 33035.JPJF01000035_gene3488 1.78e-302 828.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XYPG@572511|Blautia 186801|Clostridia V COG COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE KKPNOBBG_01270 658086.HMPREF0994_06188 3.84e-256 720.0 COG3408@1|root,COG3408@2|Bacteria,1UXMW@1239|Firmicutes,24AKV@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - - ko:K03931 - - - - ko00000 - GH63 - Trehalase KKPNOBBG_01271 1226325.HMPREF1548_04784 2.05e-158 448.0 COG0395@1|root,COG0395@2|Bacteria,1TSAB@1239|Firmicutes,249PI@186801|Clostridia,36RKK@31979|Clostridiaceae 186801|Clostridia U Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01272 1226325.HMPREF1548_04783 7.25e-170 481.0 COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,248DR@186801|Clostridia,36H7T@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01273 658086.HMPREF0994_06191 6.07e-215 607.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,27ITT@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01274 1226325.HMPREF1548_04781 2.42e-115 355.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSKR@1239|Firmicutes,24AFC@186801|Clostridia,36FBQ@31979|Clostridiaceae 186801|Clostridia T response regulator - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01275 658086.HMPREF0994_06193 5.01e-160 477.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,27IDT@186928|unclassified Lachnospiraceae 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase KKPNOBBG_01276 33035.JPJF01000035_gene3489 0.0 869.0 COG0069@1|root,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3XZ2S@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_7,Fer4_9,Glu_syn_central,Glu_synthase KKPNOBBG_01277 33035.JPJF01000035_gene3490 1.98e-259 714.0 COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia 186801|Clostridia Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 KKPNOBBG_01278 33035.JPJF01000035_gene3491 3.94e-103 300.0 2DMMK@1|root,32SFZ@2|Bacteria,1VARW@1239|Firmicutes,24NN3@186801|Clostridia,3Y1M4@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01279 33035.JPJF01000035_gene3492 2.07e-70 214.0 2E8MK@1|root,332Z1@2|Bacteria,1VEEU@1239|Firmicutes,24MU8@186801|Clostridia,3Y0HA@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4430) - - - - - - - - - - - - DUF4430 KKPNOBBG_01280 33035.JPJF01000035_gene3494 0.0 952.0 COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,3XYNS@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 KKPNOBBG_01281 33035.JPJF01000035_gene3495 3.69e-174 489.0 COG0149@1|root,COG0149@2|Bacteria,1UY0I@1239|Firmicutes,248YC@186801|Clostridia,3XZDR@572511|Blautia 186801|Clostridia G Triosephosphate isomerase - - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM KKPNOBBG_01282 33035.JPJF01000035_gene3496 2.39e-151 427.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,3XYMH@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Aldolase_II KKPNOBBG_01283 33035.JPJF01000035_gene3497 5.86e-129 369.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,3XZY7@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - ko:K17195 ko00051,ko01120,map00051,map01120 - R09031 RC03111 ko00000,ko00001,ko01000 - - - Ribul_P_3_epim KKPNOBBG_01284 33035.JPJF01000035_gene3498 3.65e-207 577.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3Y04Y@572511|Blautia 186801|Clostridia C Alcohol dehydrogenase GroES-like domain - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_01285 33035.JPJF01000035_gene3499 9.75e-192 536.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3XZRN@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C KKPNOBBG_01286 33035.JPJF01000035_gene3500 1.57e-174 489.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3XZ3S@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N KKPNOBBG_01287 33035.JPJF01000035_gene3501 1.14e-146 417.0 COG1028@1|root,COG1028@2|Bacteria,1UYV1@1239|Firmicutes,24NUW@186801|Clostridia,3Y1Q4@572511|Blautia 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 KKPNOBBG_01288 33035.JPJF01000035_gene3502 2.22e-175 489.0 COG1116@1|root,COG1116@2|Bacteria,1TWYU@1239|Firmicutes,249UM@186801|Clostridia,3Y10Y@572511|Blautia 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K02049,ko:K15555 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - ABC_tran KKPNOBBG_01289 33035.JPJF01000035_gene3503 4.76e-169 473.0 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,3Y02Z@572511|Blautia 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran KKPNOBBG_01290 33035.JPJF01000035_gene3504 4.04e-167 469.0 COG0600@1|root,COG0600@2|Bacteria,1UXRD@1239|Firmicutes,25MD8@186801|Clostridia,3Y1JP@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01291 33035.JPJF01000035_gene3505 6.07e-187 520.0 COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,3Y0M7@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02050,ko:K15552,ko:K15554 ko00920,ko02010,map00920,map02010 M00188,M00435,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.2,3.A.1.17.4 - - BPD_transp_1 KKPNOBBG_01292 33035.JPJF01000035_gene3506 2.26e-245 676.0 COG0715@1|root,COG0715@2|Bacteria,1UZFI@1239|Firmicutes,24E11@186801|Clostridia 186801|Clostridia P NMT1-like family - - - ko:K15553 ko00920,ko02010,map00920,map02010 M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.17.2 - - NMT1 KKPNOBBG_01293 33035.JPJF01000035_gene3507 2.34e-239 659.0 COG1609@1|root,COG1609@2|Bacteria,1UK1H@1239|Firmicutes,249XN@186801|Clostridia,3XZFY@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_01294 33035.JPJF01000035_gene3508 1.29e-206 576.0 COG1609@1|root,COG1609@2|Bacteria,1UK1H@1239|Firmicutes,249XN@186801|Clostridia,3XZFY@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_01295 33035.JPJF01000035_gene3517 2.32e-128 367.0 COG2715@1|root,COG2715@2|Bacteria,1V1E2@1239|Firmicutes,249G0@186801|Clostridia,3XZVF@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score spmA - - ko:K06373 - - - - ko00000 - - - Gate KKPNOBBG_01296 511051.CSE_01580 5.09e-16 81.3 COG3292@1|root,COG4447@1|root,COG3292@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - BNR_6,Cu_amine_oxidN1,PSII_BNR,RicinB_lectin_2,Sortilin-Vps10 KKPNOBBG_01299 1396141.BATP01000039_gene1365 1.24e-18 87.4 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - 3.2.1.4 ko:K01179,ko:K21449 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000,ko02000 1.B.40.2 GH5,GH9 - CBM_3,CBM_X2,HYR,fn3 KKPNOBBG_01301 397290.C810_03023 3.03e-20 88.6 COG5659@1|root,COG5659@2|Bacteria,1UJXQ@1239|Firmicutes,25FDS@186801|Clostridia 186801|Clostridia L transposition - - - - - - - - - - - - - KKPNOBBG_01302 397290.C810_03023 3.24e-53 178.0 COG5659@1|root,COG5659@2|Bacteria,1UJXQ@1239|Firmicutes,25FDS@186801|Clostridia 186801|Clostridia L transposition - - - - - - - - - - - - - KKPNOBBG_01303 33035.JPJF01000035_gene3518 1.03e-138 396.0 COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,3XZQD@572511|Blautia 186801|Clostridia S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase KKPNOBBG_01304 397287.C807_03638 4.73e-63 207.0 2FGE8@1|root,348AB@2|Bacteria,1VZSH@1239|Firmicutes,25443@186801|Clostridia,27RJG@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01308 1280692.AUJL01000014_gene3250 2.74e-194 606.0 COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae 186801|Clostridia V Permease - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_01309 903814.ELI_1949 1.2e-113 332.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,25V4X@186806|Eubacteriaceae 186801|Clostridia V ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01310 1216932.CM240_1033 6.22e-17 75.1 COG0236@1|root,COG0236@2|Bacteria,1VG07@1239|Firmicutes,24QQA@186801|Clostridia,36PAF@31979|Clostridiaceae 186801|Clostridia IQ Phosphopantetheine attachment site - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding KKPNOBBG_01311 1410668.JNKC01000005_gene2185 1.12e-95 303.0 COG1020@1|root,COG1020@2|Bacteria,1TQP2@1239|Firmicutes,24AMK@186801|Clostridia,36HCA@31979|Clostridiaceae 186801|Clostridia Q Condensation domain - - - - - - - - - - - - Condensation KKPNOBBG_01312 1410668.JNKC01000005_gene2180 3.46e-167 494.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,36UQ3@31979|Clostridiaceae 186801|Clostridia I long-chain acyl-CoA synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C KKPNOBBG_01313 1235793.C809_04002 1.43e-91 311.0 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27I9U@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,HisKA_7TM,Hpt,MASE3,Response_reg KKPNOBBG_01314 1235799.C818_02419 2.26e-43 153.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,25C05@186801|Clostridia,27U1Q@186928|unclassified Lachnospiraceae 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_01315 33035.JPJF01000035_gene3520 7.07e-211 588.0 COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,3XZ2C@572511|Blautia 186801|Clostridia M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap KKPNOBBG_01316 33035.JPJF01000149_gene1710 9.24e-185 515.0 COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,3XYJ8@572511|Blautia 186801|Clostridia H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase KKPNOBBG_01317 33035.JPJF01000149_gene1709 2.75e-169 474.0 COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,3XZ60@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yfiC - 2.1.1.223 ko:K15460 - - - - ko00000,ko01000,ko03016 - - - MTS,Methyltransf_31 KKPNOBBG_01318 33035.JPJF01000149_gene1708 9.73e-197 546.0 COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,3XYM3@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yaaT - - - - - - - - - - - PSP1 KKPNOBBG_01319 33035.JPJF01000149_gene1707 1.53e-233 643.0 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,3XYMK@572511|Blautia 186801|Clostridia L ATPase involved in DNA replication holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C KKPNOBBG_01320 537007.BLAHAN_06050 1.85e-89 267.0 COG0194@1|root,COG0194@2|Bacteria,1V3RZ@1239|Firmicutes,24HKC@186801|Clostridia,3XZXN@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 gmk_1 - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin KKPNOBBG_01321 33035.JPJF01000027_gene2727 5.18e-273 756.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,3XYX4@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C KKPNOBBG_01322 33035.JPJF01000027_gene2728 0.0 1084.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit KKPNOBBG_01323 33035.JPJF01000027_gene2729 0.0 1402.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,3XZIP@572511|Blautia 186801|Clostridia G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_01324 33035.JPJF01000027_gene2730 0.0 1161.0 COG4733@1|root,COG4733@2|Bacteria,1VSST@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 KKPNOBBG_01325 33035.JPJF01000027_gene2731 2.74e-282 774.0 COG2730@1|root,COG2730@2|Bacteria,1TQS6@1239|Firmicutes,24A54@186801|Clostridia,3Y21W@572511|Blautia 186801|Clostridia G Protein of unknown function (DUF4038) - - - - - - - - - - - - Collagen_bind_2,DUF4038 KKPNOBBG_01326 33035.JPJF01000027_gene2732 0.0 1492.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_01327 33035.JPJF01000027_gene2733 1.25e-200 559.0 COG3458@1|root,COG3458@2|Bacteria,1TS02@1239|Firmicutes,24A6N@186801|Clostridia 186801|Clostridia Q PFAM Acetyl xylan esterase - - 3.1.1.41 ko:K01060 ko00311,ko01130,map00311,map01130 - R03062 RC00020,RC00041 ko00000,ko00001,ko01000 - - - AXE1 KKPNOBBG_01328 33035.JPJF01000027_gene2734 3.45e-223 618.0 COG1063@1|root,COG1063@2|Bacteria,1U9ZD@1239|Firmicutes,24EJR@186801|Clostridia,3Y2BF@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_01329 33035.JPJF01000027_gene2735 0.0 1564.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.165,3.2.1.25 ko:K01192,ko:K15855 ko00511,ko00520,ko01100,ko04142,map00511,map00520,map01100,map04142 - R01966 RC00049 ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_01330 33035.JPJF01000027_gene2736 1.14e-139 397.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,3XZXA@572511|Blautia 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate - - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC KKPNOBBG_01331 33035.JPJF01000027_gene2737 1.61e-207 584.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_01332 33035.JPJF01000027_gene2737 5.7e-80 251.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_01333 33035.JPJF01000027_gene2738 0.0 1910.0 COG3250@1|root,COG3250@2|Bacteria,1TRQF@1239|Firmicutes,248UC@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - Glyco_hydro_106 KKPNOBBG_01334 33035.JPJF01000027_gene2739 0.0 911.0 COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia 2|Bacteria G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - 5.3.1.25,5.3.1.3 ko:K01818 ko00051,ko01120,map00051,map01120 - R03163 RC00434 ko00000,ko00001,ko01000 - - - Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2 KKPNOBBG_01335 33035.JPJF01000027_gene2740 3.19e-189 528.0 COG1082@1|root,COG1082@2|Bacteria,1UYHR@1239|Firmicutes,25C7S@186801|Clostridia,3Y2EH@572511|Blautia 186801|Clostridia G Xylose isomerase-like TIM barrel - GO:0003674,GO:0003824,GO:0005488,GO:0016853,GO:0016854,GO:0016857,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050897 5.1.3.30,5.1.3.31 ko:K18910 - - R10817,R10818 RC03111,RC03283 ko00000,ko01000 - - - AP_endonuc_2 KKPNOBBG_01336 33035.JPJF01000027_gene2741 1.69e-232 641.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_01337 33035.JPJF01000027_gene2742 0.0 990.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2J2@1239|Firmicutes,24CQK@186801|Clostridia,3Y1VC@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_01338 33035.JPJF01000027_gene2743 0.0 1093.0 COG2972@1|root,COG2972@2|Bacteria,1TRD8@1239|Firmicutes,24BXA@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_01339 33035.JPJF01000027_gene2744 0.0 1092.0 COG1653@1|root,COG1653@2|Bacteria,1UBPJ@1239|Firmicutes,25CTA@186801|Clostridia 186801|Clostridia G transport - - - - - - - - - - - - - KKPNOBBG_01340 33035.JPJF01000027_gene2745 3.96e-195 542.0 COG0395@1|root,COG0395@2|Bacteria,1TRB1@1239|Firmicutes,2488P@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01341 33035.JPJF01000027_gene2746 6.29e-112 328.0 COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,3Y1CA@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_01342 411460.RUMTOR_02681 1.05e-18 82.4 28JN4@1|root,2ZI55@2|Bacteria,1VT72@1239|Firmicutes,24AUX@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01343 658086.HMPREF0994_05502 2.36e-114 340.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,2481D@186801|Clostridia,27IPY@186928|unclassified Lachnospiraceae 186801|Clostridia U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase KKPNOBBG_01344 742765.HMPREF9457_01065 7.43e-77 229.0 COG1476@1|root,COG1476@2|Bacteria,1V4DH@1239|Firmicutes,24HSN@186801|Clostridia,27WQG@189330|Dorea 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 KKPNOBBG_01345 478749.BRYFOR_05524 6.48e-220 608.0 COG2207@1|root,COG2207@2|Bacteria,1TRV2@1239|Firmicutes,248GD@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - HTH_18 KKPNOBBG_01346 478749.BRYFOR_05525 1.78e-123 354.0 2BY0N@1|root,321KG@2|Bacteria,1TSAJ@1239|Firmicutes,24GZ0@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K16926 - M00582 - - ko00000,ko00002,ko02000 3.A.1.31 - - Trep_Strep KKPNOBBG_01347 478749.BRYFOR_05526 2.82e-147 417.0 COG0619@1|root,COG0619@2|Bacteria,1VBZE@1239|Firmicutes,24D60@186801|Clostridia 186801|Clostridia P cobalt transport protein - - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ KKPNOBBG_01348 1232453.BAIF02000007_gene1484 5.71e-305 837.0 COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,26A9G@186813|unclassified Clostridiales 186801|Clostridia G COG COG1122 ABC-type cobalt transport system, ATPase component - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran KKPNOBBG_01349 585394.RHOM_01810 0.0 1035.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247VZ@186801|Clostridia 186801|Clostridia V abc transporter atp-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_01350 411468.CLOSCI_02595 0.0 987.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247PY@186801|Clostridia,2227M@1506553|Lachnoclostridium 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_01351 657322.FPR_14450 1.17e-75 226.0 COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,24MSE@186801|Clostridia,3WK1H@541000|Ruminococcaceae 186801|Clostridia K Helix-turn-helix diphteria tox regulatory element - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress KKPNOBBG_01352 742765.HMPREF9457_03649 1.64e-89 263.0 COG1595@1|root,COG1595@2|Bacteria,1V1EX@1239|Firmicutes,24BBF@186801|Clostridia,27VRX@189330|Dorea 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r4_2 KKPNOBBG_01353 411461.DORFOR_03162 1.77e-58 182.0 2CBNB@1|root,32UW5@2|Bacteria,1VCKT@1239|Firmicutes,24N2B@186801|Clostridia,27VS2@189330|Dorea 186801|Clostridia - - - - - - - - - - - - - - HTH_17 KKPNOBBG_01354 658086.HMPREF0994_05483 1.28e-274 753.0 COG0582@1|root,COG0582@2|Bacteria,1TSR6@1239|Firmicutes,249IV@186801|Clostridia,27KWZ@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_01355 658086.HMPREF0994_05482 2.26e-251 694.0 COG0582@1|root,COG0582@2|Bacteria,1TT1I@1239|Firmicutes,24C80@186801|Clostridia,27K4H@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_01356 33035.JPJF01000019_gene4267 1.16e-41 138.0 arCOG06833@1|root,32SGF@2|Bacteria,1U5WJ@1239|Firmicutes,25K3K@186801|Clostridia,3Y0UZ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01358 33035.JPJF01000019_gene4269 0.0 1051.0 COG2060@1|root,COG2060@2|Bacteria,1TPDF@1239|Firmicutes,24868@186801|Clostridia,3XZKR@572511|Blautia 186801|Clostridia P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane kdpA - 3.6.3.12 ko:K01546 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpA KKPNOBBG_01359 33035.JPJF01000019_gene4270 0.0 1223.0 COG2216@1|root,COG2216@2|Bacteria,1TPV5@1239|Firmicutes,24835@186801|Clostridia,3XYQW@572511|Blautia 186801|Clostridia P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system kdpB - 3.6.3.12 ko:K01547 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - E1-E2_ATPase,Hydrolase KKPNOBBG_01360 33035.JPJF01000019_gene4271 4.53e-121 348.0 COG2156@1|root,COG2156@2|Bacteria,1V4GE@1239|Firmicutes,24G0R@186801|Clostridia,3Y03P@572511|Blautia 186801|Clostridia P Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex kdpC - 3.6.3.12 ko:K01548 ko02020,map02020 - - - ko00000,ko00001,ko01000 3.A.3.7 - - KdpC KKPNOBBG_01361 33035.JPJF01000019_gene4272 0.0 1181.0 COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,3XYS3@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score 7.63 - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD,Usp KKPNOBBG_01362 33035.JPJF01000019_gene4275 9.99e-142 404.0 COG1396@1|root,COG1396@2|Bacteria,1VF0W@1239|Firmicutes,24R43@186801|Clostridia,3Y0KW@572511|Blautia 186801|Clostridia K Psort location CytoplasmicMembrane, score - - - - - - - - - - - - HTH_3 KKPNOBBG_01363 33035.JPJF01000019_gene4276 1.36e-65 202.0 COG0727@1|root,COG0727@2|Bacteria,1V67G@1239|Firmicutes,24I48@186801|Clostridia 186801|Clostridia S Putative zinc- or iron-chelating domain - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC KKPNOBBG_01364 33035.JPJF01000019_gene4277 0.0 1648.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,3XYMW@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 tetP - - - - - - - - - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP KKPNOBBG_01365 904314.SEVCU012_1847 3.58e-18 90.5 COG0583@1|root,COG0583@2|Bacteria,1TQ6Y@1239|Firmicutes,4HB94@91061|Bacilli,4GXY2@90964|Staphylococcaceae 91061|Bacilli K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01366 1087481.AGFX01000013_gene3001 3.45e-73 244.0 COG0404@1|root,COG0404@2|Bacteria,1UZB4@1239|Firmicutes 1239|Firmicutes E Belongs to the GcvT family - - - - - - - - - - - - GCV_T,GCV_T_C KKPNOBBG_01367 33035.JPJF01000019_gene4278 7.95e-170 478.0 COG0583@1|root,COG0583@2|Bacteria,1TRJK@1239|Firmicutes,24AY4@186801|Clostridia,3XZVT@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01368 33035.JPJF01000019_gene4279 4.31e-137 390.0 COG3619@1|root,COG3619@2|Bacteria,1V1VQ@1239|Firmicutes,24DUE@186801|Clostridia,3Y00W@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF1275 KKPNOBBG_01369 33035.JPJF01000019_gene4281 3.06e-287 790.0 COG0642@1|root,COG2205@2|Bacteria,1TS12@1239|Firmicutes,24AAW@186801|Clostridia,3Y16H@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01370 33035.JPJF01000019_gene4282 5.56e-154 434.0 COG0745@1|root,COG0745@2|Bacteria,1TYPK@1239|Firmicutes,247Y9@186801|Clostridia,3Y11C@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01371 33035.JPJF01000019_gene4283 7.63e-169 473.0 COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,253U3@186801|Clostridia,3Y1EC@572511|Blautia 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K20459 ko02010,map02010 M00254,M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC_tran KKPNOBBG_01372 33035.JPJF01000019_gene4284 2.33e-137 392.0 COG4200@1|root,COG4200@2|Bacteria,1TP4G@1239|Firmicutes,249XU@186801|Clostridia,3Y26T@572511|Blautia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K20460 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC2_membrane_4 KKPNOBBG_01373 33035.JPJF01000019_gene4285 3.36e-154 436.0 COG4200@1|root,COG4200@2|Bacteria,1TRGZ@1239|Firmicutes,2498Y@186801|Clostridia,3Y1ZR@572511|Blautia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K20461 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC2_membrane_4 KKPNOBBG_01374 33035.JPJF01000019_gene4286 1.78e-29 107.0 2EIWS@1|root,33CN3@2|Bacteria,1VMC7@1239|Firmicutes,24R1C@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01375 33035.JPJF01000019_gene4287 1.46e-96 286.0 COG0622@1|root,COG0622@2|Bacteria,1V7VB@1239|Firmicutes,24PEZ@186801|Clostridia,3Y0BJ@572511|Blautia 186801|Clostridia S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 KKPNOBBG_01376 33035.JPJF01000019_gene4288 2.14e-262 724.0 COG0534@1|root,COG0534@2|Bacteria,1TP6V@1239|Firmicutes,248EF@186801|Clostridia,3XZ6H@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_01377 33035.JPJF01000019_gene4289 1.7e-280 769.0 COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,3XYWD@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AIRS,AIRS_C,HTH_3 KKPNOBBG_01378 33035.JPJF01000019_gene4290 5.03e-231 637.0 COG0451@1|root,COG0451@2|Bacteria,1TRTD@1239|Firmicutes,24AFT@186801|Clostridia 186801|Clostridia M NAD dependent epimerase dehydratase family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase KKPNOBBG_01379 33035.JPJF01000019_gene4291 3.47e-129 367.0 COG1309@1|root,COG1309@2|Bacteria,1V89E@1239|Firmicutes,24JQ7@186801|Clostridia,3Y03H@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_01380 33035.JPJF01000019_gene4292 9.11e-207 573.0 COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3XZNN@572511|Blautia 186801|Clostridia H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12020 NadA KKPNOBBG_01381 33035.JPJF01000019_gene4293 1.08e-305 834.0 COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3XZEH@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 9.36 nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C KKPNOBBG_01382 33035.JPJF01000019_gene4294 3.51e-191 532.0 COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,3XZ2V@572511|Blautia 186801|Clostridia H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12010 QRPTase_C,QRPTase_N KKPNOBBG_01383 33035.JPJF01000019_gene4295 4.67e-116 333.0 COG1827@1|root,COG1827@2|Bacteria,1V6EY@1239|Firmicutes,24JF2@186801|Clostridia,3Y067@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 niaR - - ko:K07105 - - - - ko00000 - - - 3H,HTH_11 KKPNOBBG_01384 33035.JPJF01000019_gene4296 8.41e-102 296.0 COG0782@1|root,COG0782@2|Bacteria,1V1G3@1239|Firmicutes,24FRJ@186801|Clostridia,3XZZN@572511|Blautia 186801|Clostridia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA_2 - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N KKPNOBBG_01385 33035.JPJF01000019_gene4297 8.33e-188 522.0 COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,3XZ1R@572511|Blautia 186801|Clostridia F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate - - 2.4.2.1 ko:K03783 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 KKPNOBBG_01386 33035.JPJF01000019_gene4298 0.0 930.0 COG2972@1|root,COG2972@2|Bacteria,1TSE1@1239|Firmicutes 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_01387 33035.JPJF01000019_gene4299 6.38e-292 799.0 COG1653@1|root,COG1653@2|Bacteria,1TQJU@1239|Firmicutes,24AHT@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_01388 33035.JPJF01000019_gene4300 3.26e-197 548.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia 2|Bacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 KKPNOBBG_01389 33035.JPJF01000019_gene4301 4.94e-175 489.0 COG0395@1|root,COG0395@2|Bacteria,1TSJ9@1239|Firmicutes,24ERB@186801|Clostridia 186801|Clostridia P abc transporter permease protein - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01390 33035.JPJF01000019_gene4302 0.0 946.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,25B1H@186801|Clostridia 186801|Clostridia T Helix-turn-helix domain - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01391 33035.JPJF01000019_gene4303 8.94e-272 744.0 COG0673@1|root,COG0673@2|Bacteria,1V0MQ@1239|Firmicutes,24CZ7@186801|Clostridia,3XZSH@572511|Blautia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_01392 33035.JPJF01000019_gene4305 6.87e-156 440.0 COG1246@1|root,COG1246@2|Bacteria,1TRN6@1239|Firmicutes,2484V@186801|Clostridia 186801|Clostridia E YoaP-like yoaP - - - - - - - - - - - Acetyltransf_1,YoaP KKPNOBBG_01393 33035.JPJF01000019_gene4306 0.0 972.0 COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,3XYUW@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU KKPNOBBG_01394 33035.JPJF01000019_gene4307 1.41e-155 437.0 COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24D6A@186801|Clostridia,3XYH5@572511|Blautia 186801|Clostridia T positive response regulator for pho regulon phoB - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_01395 33035.JPJF01000019_gene4308 5.23e-295 808.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3XZJP@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like KKPNOBBG_01396 33035.JPJF01000019_gene4309 2.16e-123 363.0 COG3595@1|root,COG3595@2|Bacteria,1VGMF@1239|Firmicutes,24ICY@186801|Clostridia 186801|Clostridia S Putative adhesin - - - - - - - - - - - - DUF4097 KKPNOBBG_01397 33035.JPJF01000019_gene4310 5e-132 377.0 2AKUT@1|root,31BMY@2|Bacteria,1V967@1239|Firmicutes,24DHX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01398 33035.JPJF01000019_gene4311 4.5e-73 219.0 COG1695@1|root,COG1695@2|Bacteria,1VA94@1239|Firmicutes,24N33@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR KKPNOBBG_01399 33035.JPJF01000019_gene4312 5.1e-93 272.0 2ERDA@1|root,33IYY@2|Bacteria,1VQDH@1239|Firmicutes,24MN4@186801|Clostridia,3Y1ZV@572511|Blautia 186801|Clostridia S Spore coat associated protein JA (CotJA) - - - - - - - - - - - - CotJA,CotJB KKPNOBBG_01400 33035.JPJF01000019_gene4313 1.96e-142 402.0 COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,3XYJ2@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 cotJC - - ko:K06334 - - - - ko00000 - - - Mn_catalase KKPNOBBG_01401 33035.JPJF01000019_gene4314 0.0 897.0 COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,3XYTG@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH KKPNOBBG_01402 33035.JPJF01000019_gene4315 1.18e-308 843.0 COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,3XZ02@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N KKPNOBBG_01403 33035.JPJF01000019_gene4316 1.74e-37 125.0 2EGE3@1|root,33A60@2|Bacteria,1VMF7@1239|Firmicutes,24UMV@186801|Clostridia,3Y0J2@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - - KKPNOBBG_01404 33035.JPJF01000019_gene4317 0.0 1414.0 COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,3XZ79@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score cadA - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase KKPNOBBG_01405 33035.JPJF01000018_gene4347 1.61e-157 442.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,3XZ85@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01406 33035.JPJF01000018_gene4346 6.8e-282 774.0 COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,3XZ50@572511|Blautia 186801|Clostridia E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh KKPNOBBG_01407 33035.JPJF01000018_gene4345 3.65e-157 445.0 COG1266@1|root,COG1266@2|Bacteria,1W749@1239|Firmicutes,25MB2@186801|Clostridia,3Y0CJ@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Abi KKPNOBBG_01408 33035.JPJF01000018_gene4344 8.97e-38 127.0 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,24QPB@186801|Clostridia,3Y0JP@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_01409 33035.JPJF01000018_gene4343 1.42e-119 348.0 2C5AG@1|root,32T9Z@2|Bacteria,1VDDZ@1239|Firmicutes,24S1R@186801|Clostridia,3Y1SX@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF3169) - - - - - - - - - - - - DUF3169 KKPNOBBG_01410 33035.JPJF01000018_gene4342 8e-199 552.0 COG4152@1|root,COG4152@2|Bacteria,1TR06@1239|Firmicutes,249YC@186801|Clostridia,3Y10M@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4162) natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 KKPNOBBG_01411 33035.JPJF01000018_gene4341 6.08e-244 677.0 COG1668@1|root,COG1668@2|Bacteria,1TXRK@1239|Firmicutes,248YS@186801|Clostridia,3Y1AQ@572511|Blautia 186801|Clostridia CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 KKPNOBBG_01412 33035.JPJF01000018_gene4340 2.72e-169 473.0 COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia,3XYUH@572511|Blautia 186801|Clostridia G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso KKPNOBBG_01413 33035.JPJF01000018_gene4339 7.47e-204 565.0 COG2207@1|root,COG2207@2|Bacteria,1UYFM@1239|Firmicutes,247WN@186801|Clostridia,3XZJ7@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_01414 33035.JPJF01000018_gene4338 1.79e-216 598.0 COG1209@1|root,COG1209@2|Bacteria,1TPR2@1239|Firmicutes,2490F@186801|Clostridia,3XYY9@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - NTP_transferase KKPNOBBG_01415 33035.JPJF01000018_gene4337 1.89e-255 701.0 COG2334@1|root,COG2334@2|Bacteria,1UXS1@1239|Firmicutes,25MC4@186801|Clostridia,3XZ7J@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - APH KKPNOBBG_01416 33035.JPJF01000018_gene4336 3.24e-250 686.0 COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,247M9@186801|Clostridia,3XYYJ@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd KKPNOBBG_01417 33035.JPJF01000018_gene4335 0.0 954.0 COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,3XYIV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF1846 KKPNOBBG_01418 33035.JPJF01000018_gene4334 0.0 1123.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,3XYZH@572511|Blautia 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 KKPNOBBG_01419 33035.JPJF01000018_gene4333 0.0 1180.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,3XZ8C@572511|Blautia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N KKPNOBBG_01420 33035.JPJF01000018_gene4332 4.23e-218 602.0 COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,3XZ5K@572511|Blautia 186801|Clostridia H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N KKPNOBBG_01421 33035.JPJF01000018_gene4331 1.57e-208 578.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3XYHF@572511|Blautia 186801|Clostridia GK Psort location Cytoplasmic, score glcK - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK KKPNOBBG_01422 33035.JPJF01000018_gene4330 0.0 1552.0 COG5009@1|root,COG5009@2|Bacteria,1UI0H@1239|Firmicutes,25E95@186801|Clostridia,3XZCE@572511|Blautia 186801|Clostridia M Psort location Extracellular, score 9.55 - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase KKPNOBBG_01423 1122917.KB899680_gene423 1.1e-43 160.0 COG0673@1|root,COG0673@2|Bacteria,1VAKD@1239|Firmicutes,4IPNF@91061|Bacilli,2760T@186822|Paenibacillaceae 91061|Bacilli S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_01424 97139.C824_02420 5.49e-169 484.0 COG1653@1|root,COG1653@2|Bacteria,1U4H4@1239|Firmicutes,24A14@186801|Clostridia,36UPU@31979|Clostridiaceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01425 97139.C824_02418 4.09e-169 477.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,36QM2@31979|Clostridiaceae 186801|Clostridia U Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01426 97139.C824_02417 7.81e-160 453.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,24G0B@186801|Clostridia,36K41@31979|Clostridiaceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01427 97139.C824_02416 3.47e-195 549.0 COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,36MWX@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_01428 1197130.BAFM01000030_gene3134 8.01e-81 258.0 COG4948@1|root,arCOG01168@2157|Archaea,2XUBS@28890|Euryarchaeota,23UR5@183963|Halobacteria 183963|Halobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - - - - - - - - - - MR_MLE_C,MR_MLE_N KKPNOBBG_01429 97139.C824_02414 6.05e-201 561.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_01430 658655.HMPREF0988_02285 5.05e-79 238.0 COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,24IS7@186801|Clostridia,27ST1@186928|unclassified Lachnospiraceae 186801|Clostridia J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc KKPNOBBG_01431 97139.C824_02410 1.85e-75 229.0 COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,24IS7@186801|Clostridia,36NSX@31979|Clostridiaceae 186801|Clostridia J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc KKPNOBBG_01432 97139.C824_02409 3.82e-166 470.0 COG0684@1|root,COG0684@2|Bacteria,1UY1F@1239|Firmicutes,24CQP@186801|Clostridia 186801|Clostridia H Aldolase/RraA - - - - - - - - - - - - RraA-like KKPNOBBG_01433 33035.JPJF01000018_gene4329 5.99e-136 387.0 COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,3XYJT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yvyE - - - - - - - - - - - DUF1949,UPF0029 KKPNOBBG_01434 33035.JPJF01000018_gene4328 4.63e-104 302.0 COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,3XZDN@572511|Blautia 186801|Clostridia O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase KKPNOBBG_01435 33035.JPJF01000018_gene4326 2.78e-98 285.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,3Y003@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE KKPNOBBG_01436 33035.JPJF01000018_gene4325 2.33e-154 435.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,3XYQX@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 KKPNOBBG_01437 33035.JPJF01000018_gene4324 2.36e-84 250.0 COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,3Y0DF@572511|Blautia 186801|Clostridia K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 KKPNOBBG_01438 33035.JPJF01000018_gene4323 4.14e-55 171.0 2EJD6@1|root,33D47@2|Bacteria,1VKED@1239|Firmicutes,24T7S@186801|Clostridia,3Y0IQ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01439 33035.JPJF01000018_gene4322 4.93e-214 591.0 COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,3XZ6W@572511|Blautia 186801|Clostridia S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 KKPNOBBG_01440 33035.JPJF01000018_gene4321 2.06e-235 649.0 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,3XYPY@572511|Blautia 186801|Clostridia H Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 KKPNOBBG_01441 33035.JPJF01000018_gene4320 2.81e-145 411.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,3XZ8R@572511|Blautia 186801|Clostridia I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS20335 IspD KKPNOBBG_01444 33035.JPJF01000016_gene4171 8.1e-49 155.0 2C9HP@1|root,33Z9H@2|Bacteria,1W1CU@1239|Firmicutes,25441@186801|Clostridia,3Y0HT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01445 33035.JPJF01000016_gene4170 1.13e-226 625.0 COG1533@1|root,COG1533@2|Bacteria,1TPA3@1239|Firmicutes,249NM@186801|Clostridia 186801|Clostridia L Spore photoproduct lyase - - 4.1.99.14 ko:K03716 - - - - ko00000,ko01000 - - - - KKPNOBBG_01446 33035.JPJF01000016_gene4169 6.23e-185 516.0 COG2207@1|root,COG2207@2|Bacteria,1V48H@1239|Firmicutes,248BW@186801|Clostridia,3XZC4@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 KKPNOBBG_01447 33035.JPJF01000016_gene4168 0.0 1561.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,3Y07X@572511|Blautia 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - - - - - - - - - - - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_01449 1449050.JNLE01000003_gene1595 4.52e-81 239.0 29A02@1|root,2ZX1N@2|Bacteria,1V48B@1239|Firmicutes,24HF1@186801|Clostridia,36J4Y@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01451 33035.JPJF01000016_gene4166 5.42e-105 303.0 COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,25MQU@186801|Clostridia,3Y0W6@572511|Blautia 186801|Clostridia K RNA polymerase sigma-70 factor, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_01453 33035.JPJF01000016_gene4163 1.57e-164 465.0 COG0789@1|root,COG0789@2|Bacteria,1UF0K@1239|Firmicutes,256IS@186801|Clostridia 186801|Clostridia K transcriptional regulator, MerR - - - - - - - - - - - - MerR_1,TipAS KKPNOBBG_01454 33035.JPJF01000016_gene4162 0.0 1165.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3Y0AT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_01455 33035.JPJF01000016_gene4161 2.11e-172 482.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,3XZDV@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC_tran KKPNOBBG_01456 33035.JPJF01000016_gene4160 4.4e-226 625.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,3Y000@572511|Blautia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_01457 33035.JPJF01000016_gene4159 1.03e-139 397.0 COG0745@1|root,COG0745@2|Bacteria,1V0KM@1239|Firmicutes,24DU7@186801|Clostridia,3Y2AW@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01458 33035.JPJF01000016_gene4158 1.25e-107 313.0 COG0406@1|root,COG0406@2|Bacteria,1VCU1@1239|Firmicutes,24Q22@186801|Clostridia 186801|Clostridia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 KKPNOBBG_01459 33035.JPJF01000016_gene4157 2.1e-297 816.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZ7G@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_01460 33035.JPJF01000016_gene4156 1.04e-161 454.0 arCOG13338@1|root,2Z9XC@2|Bacteria,1UPRH@1239|Firmicutes,25HMN@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF5058) - - - - - - - - - - - - DUF5058 KKPNOBBG_01461 33035.JPJF01000016_gene4155 1.61e-146 414.0 28N4D@1|root,2ZB9V@2|Bacteria,1UPRR@1239|Firmicutes,24MJV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01462 33035.JPJF01000016_gene4154 0.0 915.0 COG0624@1|root,COG0624@2|Bacteria,1TRHJ@1239|Firmicutes,24DN5@186801|Clostridia 186801|Clostridia E Psort location Cytoplasmic, score - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 KKPNOBBG_01463 33035.JPJF01000016_gene4153 2.04e-181 508.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TQKE@1239|Firmicutes,24DBB@186801|Clostridia 186801|Clostridia K AraC family - - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 KKPNOBBG_01464 33035.JPJF01000016_gene4152 8.07e-241 664.0 COG3049@1|root,COG3049@2|Bacteria,1UHUX@1239|Firmicutes,25E3I@186801|Clostridia 186801|Clostridia M Acyl-coenzyme A 6-aminopenicillanic acid acyl-transferase - - - - - - - - - - - - AAT KKPNOBBG_01465 33035.JPJF01000016_gene4151 3.57e-85 254.0 COG3279@1|root,COG3279@2|Bacteria,1V6EJ@1239|Firmicutes,25B1E@186801|Clostridia 186801|Clostridia K LytTr DNA-binding domain - - - - - - - - - - - - LytTR KKPNOBBG_01466 33035.JPJF01000016_gene4150 1.31e-77 234.0 2DNEV@1|root,32X5D@2|Bacteria,1VCIU@1239|Firmicutes,24SKC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01467 33035.JPJF01000016_gene4149 6.15e-171 480.0 COG1131@1|root,COG1131@2|Bacteria,1TRNT@1239|Firmicutes,24B5J@186801|Clostridia,3Y0Y2@572511|Blautia 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01468 33035.JPJF01000016_gene4148 4.95e-135 385.0 COG1668@1|root,COG1668@2|Bacteria,1UI0E@1239|Firmicutes,25E94@186801|Clostridia 186801|Clostridia CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 KKPNOBBG_01469 33035.JPJF01000016_gene4147 0.0 888.0 COG2508@1|root,COG2508@2|Bacteria,1V5QP@1239|Firmicutes,24IVE@186801|Clostridia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_01470 33035.JPJF01000016_gene4146 9.25e-293 802.0 COG2610@1|root,COG2610@2|Bacteria,1TUM6@1239|Firmicutes,25MFA@186801|Clostridia,3Y1YR@572511|Blautia 186801|Clostridia EG GntP family permease - - - - - - - - - - - - GntP_permease KKPNOBBG_01471 33035.JPJF01000016_gene4145 2.07e-241 664.0 COG0407@1|root,COG0407@2|Bacteria,1V9U0@1239|Firmicutes 1239|Firmicutes H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01472 33035.JPJF01000016_gene4144 1.31e-203 566.0 COG0583@1|root,COG0583@2|Bacteria,1UYAI@1239|Firmicutes,24BA8@186801|Clostridia,3XZQR@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01473 33035.JPJF01000016_gene4143 0.0 907.0 COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,2483Z@186801|Clostridia,3Y0Z4@572511|Blautia 186801|Clostridia E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 KKPNOBBG_01474 33035.JPJF01000016_gene4142 4.07e-184 514.0 COG3588@1|root,COG3588@2|Bacteria,1TPUJ@1239|Firmicutes,24924@186801|Clostridia,3Y16B@572511|Blautia 186801|Clostridia G Fructose-bisphosphate aldolase class-I fda - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic KKPNOBBG_01476 33035.JPJF01000016_gene4141 1.28e-184 514.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,3Y1RX@572511|Blautia 186801|Clostridia K DeoR C terminal sensor domain - - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_01477 33035.JPJF01000016_gene4140 0.0 905.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,25MFQ@186801|Clostridia,3Y1RK@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_01478 33035.JPJF01000016_gene4139 1.07e-209 581.0 COG1175@1|root,COG1175@2|Bacteria,1UYKA@1239|Firmicutes,24FGT@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01479 33035.JPJF01000016_gene4138 6.89e-194 538.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3Y2ED@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01480 33035.JPJF01000016_gene4137 1.26e-250 690.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XYK4@572511|Blautia 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran KKPNOBBG_01481 33035.JPJF01000016_gene4136 2.92e-243 671.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XYK4@572511|Blautia 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran KKPNOBBG_01482 33035.JPJF01000016_gene4135 2.48e-275 753.0 COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,24BVD@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D KKPNOBBG_01483 33035.JPJF01000016_gene4134 0.0 960.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_01484 33035.JPJF01000016_gene4133 5.24e-237 653.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25E93@186801|Clostridia,3Y1HJ@572511|Blautia 186801|Clostridia CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_01485 33035.JPJF01000016_gene4132 1.86e-296 815.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XYSC@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_01486 33035.JPJF01000016_gene4131 1.86e-267 739.0 COG1109@1|root,COG1109@2|Bacteria,1TS6S@1239|Firmicutes,2491F@186801|Clostridia 186801|Clostridia G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II manB - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV KKPNOBBG_01487 33035.JPJF01000016_gene4130 4.24e-96 283.0 2BD3C@1|root,3320H@2|Bacteria,1VHD7@1239|Firmicutes,24S6N@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01488 33035.JPJF01000016_gene4129 1.61e-138 394.0 COG2819@1|root,COG2819@2|Bacteria,1V1TT@1239|Firmicutes,24GDE@186801|Clostridia,3Y0P9@572511|Blautia 186801|Clostridia S hydrolase of the alpha beta superfamily - - - - - - - - - - - - Esterase KKPNOBBG_01489 33035.JPJF01000016_gene4128 8.18e-141 399.0 COG0727@1|root,COG0727@2|Bacteria,1TT6P@1239|Firmicutes,24BWS@186801|Clostridia,3XZVI@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06940 - - - - ko00000 - - - CxxCxxCC KKPNOBBG_01490 33035.JPJF01000016_gene4126 0.0 1377.0 COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,3XZ4C@572511|Blautia 186801|Clostridia G COG COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 KKPNOBBG_01491 33035.JPJF01000016_gene4125 9.92e-230 636.0 COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,24AQ9@186801|Clostridia,3XYMM@572511|Blautia 186801|Clostridia S N-methylation of lysine residues in flagellin fliU - - ko:K18475 - - - - ko00000,ko01000,ko02035 - - - CxxCxxCC KKPNOBBG_01492 33035.JPJF01000016_gene4124 6.35e-202 561.0 COG0042@1|root,COG0042@2|Bacteria,1TRJM@1239|Firmicutes,247R5@186801|Clostridia,3XZ2T@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - - - - - - - - - - Dus KKPNOBBG_01494 33035.JPJF01000016_gene4122 0.0 1066.0 COG2199@1|root,COG2199@2|Bacteria,1V8R1@1239|Firmicutes,24FNF@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3,dCache_1 KKPNOBBG_01495 33035.JPJF01000016_gene4121 0.0 1157.0 COG4637@1|root,COG4637@2|Bacteria,1UZCB@1239|Firmicutes,248WE@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_15,AAA_21 KKPNOBBG_01496 33035.JPJF01000016_gene4120 4.58e-160 454.0 COG0564@1|root,COG0564@2|Bacteria,1W6ZU@1239|Firmicutes,24YS1@186801|Clostridia,3Y055@572511|Blautia 186801|Clostridia J RNA pseudouridylate synthase - - - - - - - - - - - - PseudoU_synth_2 KKPNOBBG_01497 33035.JPJF01000016_gene4119 0.0 961.0 COG3835@1|root,COG3835@2|Bacteria,1TR5V@1239|Firmicutes,25E92@186801|Clostridia 186801|Clostridia KT Purine catabolism regulatory protein-like family - - - - - - - - - - - - HTH_30,PucR KKPNOBBG_01498 33035.JPJF01000016_gene4118 4e-255 701.0 COG3535@1|root,COG3535@2|Bacteria,1TR39@1239|Firmicutes,24A65@186801|Clostridia,3Y244@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF917) - - - ko:K09703 - - - - ko00000 - - - DUF917 KKPNOBBG_01499 33035.JPJF01000016_gene4117 0.0 949.0 COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,24AJ7@186801|Clostridia,3Y0KA@572511|Blautia 186801|Clostridia EQ Hydantoinase/oxoprolinase - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A KKPNOBBG_01500 33035.JPJF01000016_gene4116 4.15e-177 497.0 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,3Y2EF@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_01501 33035.JPJF01000016_gene4115 1.93e-80 240.0 COG1846@1|root,COG1846@2|Bacteria,1TTKE@1239|Firmicutes,25MWQ@186801|Clostridia,3Y23H@572511|Blautia 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 KKPNOBBG_01502 33035.JPJF01000016_gene4114 0.0 1030.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3XZEC@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_01503 33035.JPJF01000016_gene4113 0.0 1199.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3XZBH@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_01504 33035.JPJF01000016_gene3845 9.21e-63 229.0 COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,24FVB@186801|Clostridia,3Y017@572511|Blautia 186801|Clostridia KT BlaR1 peptidase M56 - - - ko:K02172 ko01501,map01501 M00627 - - ko00000,ko00001,ko00002,ko01002,ko01504 - - - DUF4097,DUF4825,DUF4829,Peptidase_M56 KKPNOBBG_01505 33035.JPJF01000016_gene4111 4.47e-63 193.0 COG3254@1|root,COG3254@2|Bacteria,1VA1C@1239|Firmicutes,24JG9@186801|Clostridia,3Y0GA@572511|Blautia 186801|Clostridia G Involved in the anomeric conversion of L-rhamnose rhaM - 5.1.3.32 ko:K03534 - - R10819 RC00563 ko00000,ko01000 - - - rhaM KKPNOBBG_01506 33035.JPJF01000016_gene4110 4.73e-57 179.0 COG4898@1|root,COG4898@2|Bacteria,1V6U6@1239|Firmicutes,24I63@186801|Clostridia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - DUF2200 KKPNOBBG_01507 1123075.AUDP01000007_gene2792 4.44e-101 298.0 COG0431@1|root,COG0431@2|Bacteria,1V70S@1239|Firmicutes,24FJ8@186801|Clostridia,3WKB6@541000|Ruminococcaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - Flavodoxin_2 KKPNOBBG_01508 1123075.AUDP01000007_gene2791 9.13e-88 261.0 COG0655@1|root,COG0655@2|Bacteria,1V6U2@1239|Firmicutes,24GJC@186801|Clostridia,3WK5D@541000|Ruminococcaceae 186801|Clostridia S Alpha beta hydrolase - - - - - - - - - - - - FMN_red KKPNOBBG_01509 180332.JTGN01000007_gene3787 6.12e-80 243.0 COG1309@1|root,COG1309@2|Bacteria,1U9UE@1239|Firmicutes,24M4I@186801|Clostridia 186801|Clostridia K Transcriptional regulator - - - - - - - - - - - - TetR_N,WHG KKPNOBBG_01510 1519439.JPJG01000085_gene462 6.11e-120 347.0 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,248B6@186801|Clostridia,2N8XD@216572|Oscillospiraceae 186801|Clostridia T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01511 471875.RUMLAC_00940 1.05e-109 330.0 COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,249HQ@186801|Clostridia,3WHVM@541000|Ruminococcaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_01512 1454004.AW11_02872 6.55e-25 101.0 COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - ko:K05796 - - - - ko00000 - - - Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9 KKPNOBBG_01513 931626.Awo_c12420 1.56e-65 237.0 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,25WW8@186806|Eubacteriaceae 186801|Clostridia C Aldehyde ferredoxin oxidoreductase, N-terminal domain - - 1.2.7.5 ko:K03738,ko:K19515 ko00030,ko00362,ko01100,ko01120,ko01200,map00030,map00362,map01100,map01120,map01200 M00309,M00541 R08571,R10961 RC00242,RC01839 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N KKPNOBBG_01514 33035.JPJF01000016_gene4105 4.43e-307 838.0 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3XZ05@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N KKPNOBBG_01515 33035.JPJF01000016_gene4104 4.01e-44 143.0 29V17@1|root,30GEB@2|Bacteria,1UFV5@1239|Firmicutes,25MT2@186801|Clostridia,3Y0QI@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01516 33035.JPJF01000016_gene4103 1.34e-123 353.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,24GD7@186801|Clostridia,3XZ2G@572511|Blautia 186801|Clostridia S SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP KKPNOBBG_01517 33035.JPJF01000016_gene4102 3.57e-282 773.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3XYYM@572511|Blautia 186801|Clostridia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH KKPNOBBG_01518 33035.JPJF01000016_gene4101 1.17e-76 229.0 2E99X@1|root,333HZ@2|Bacteria,1VFDA@1239|Firmicutes,24RP0@186801|Clostridia,3Y0PY@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01519 33035.JPJF01000016_gene4100 8.33e-183 509.0 COG2162@1|root,COG2162@2|Bacteria,1V6M1@1239|Firmicutes,24G0C@186801|Clostridia 186801|Clostridia Q N-acetyltransferase - - 2.3.1.118 ko:K00675 - - - - ko00000,ko01000 - - - Acetyltransf_2 KKPNOBBG_01520 33035.JPJF01000016_gene4099 1.49e-251 691.0 COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,3XZNX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF362 KKPNOBBG_01521 33035.JPJF01000016_gene4098 2.42e-236 650.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01522 33035.JPJF01000016_gene4097 1.2e-248 685.0 COG0477@1|root,COG2814@2|Bacteria,1W76W@1239|Firmicutes,25M5F@186801|Clostridia,3Y1X9@572511|Blautia 186801|Clostridia EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_01523 33035.JPJF01000016_gene4096 0.0 917.0 COG2508@1|root,COG2508@2|Bacteria,1VTW2@1239|Firmicutes,24YNS@186801|Clostridia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_01524 33035.JPJF01000016_gene4095 5.63e-157 443.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,3XYYY@572511|Blautia 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM KKPNOBBG_01525 33035.JPJF01000016_gene4094 0.0 1449.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3XZ2A@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like KKPNOBBG_01526 33035.JPJF01000016_gene4093 2.06e-78 233.0 COG1393@1|root,COG1393@2|Bacteria,1VA5Q@1239|Firmicutes,24JGY@186801|Clostridia,3Y05X@572511|Blautia 186801|Clostridia P Belongs to the ArsC family - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC,Glutaredoxin KKPNOBBG_01527 33035.JPJF01000016_gene4092 0.0 1061.0 COG2199@1|root,COG2606@1|root,COG2199@2|Bacteria,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,3Y1PZ@572511|Blautia 186801|Clostridia T Aminoacyl-tRNA editing domain EbsC - - - - - - - - - - - tRNA_edit KKPNOBBG_01528 33035.JPJF01000016_gene4090 4.24e-166 468.0 COG2145@1|root,COG2145@2|Bacteria,1V1R6@1239|Firmicutes,248AC@186801|Clostridia,3XZZP@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ) thiM - 2.7.1.50 ko:K00878 ko00730,ko01100,map00730,map01100 M00127 R04448 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HK KKPNOBBG_01529 33035.JPJF01000016_gene4089 9.38e-129 369.0 COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,3XZWG@572511|Blautia 186801|Clostridia H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI KKPNOBBG_01530 33035.JPJF01000016_gene4088 3.25e-123 354.0 COG0637@1|root,COG0637@2|Bacteria,1VCK3@1239|Firmicutes,25B1D@186801|Clostridia 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 KKPNOBBG_01531 33035.JPJF01000016_gene4087 6.57e-171 479.0 COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,3XYTK@572511|Blautia 186801|Clostridia H Phosphomethylpyrimidine kinase thiD - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 ko:K00868,ko:K00941,ko:K14153 ko00730,ko00750,ko01100,map00730,map00750,map01100 M00127 R00174,R01909,R02493,R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin KKPNOBBG_01532 33035.JPJF01000016_gene4086 0.0 1499.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3XZ2A@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 pflB - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like KKPNOBBG_01533 33035.JPJF01000016_gene4085 1.06e-143 407.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,3XYYY@572511|Blautia 186801|Clostridia C Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM KKPNOBBG_01534 33035.JPJF01000016_gene4084 2.62e-188 526.0 2C6CR@1|root,2Z7X4@2|Bacteria,1UY2Y@1239|Firmicutes,24EJP@186801|Clostridia,3XZW6@572511|Blautia 186801|Clostridia S Putative, 10TM heavy-metal exporter - - - ko:K07089 - - - - ko00000 - - - ArsP_2 KKPNOBBG_01535 33035.JPJF01000016_gene4083 1.33e-119 343.0 2DIV4@1|root,30473@2|Bacteria,1V5EC@1239|Firmicutes,24IZE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01536 33035.JPJF01000016_gene4082 1.78e-42 138.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia 186801|Clostridia K Cold shock protein cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD KKPNOBBG_01537 1235793.C809_01506 1.57e-98 289.0 COG1514@1|root,COG1514@2|Bacteria,1VGSY@1239|Firmicutes,24ETC@186801|Clostridia,27TWE@186928|unclassified Lachnospiraceae 186801|Clostridia J 2'-5' RNA ligase superfamily - - - - - - - - - - - - 2_5_RNA_ligase2 KKPNOBBG_01538 397291.C804_03341 3.53e-26 97.4 28RSS@1|root,2ZE56@2|Bacteria,1W2HX@1239|Firmicutes,24UZT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01539 33035.JPJF01000016_gene4072 0.0 921.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,3XYH4@572511|Blautia 186801|Clostridia O AAA domain (dynein-related subfamily) - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA KKPNOBBG_01541 33035.JPJF01000015_gene4933 1.05e-232 642.0 COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,3XYY6@572511|Blautia 186801|Clostridia NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE KKPNOBBG_01542 33035.JPJF01000015_gene4932 6.2e-73 222.0 2EIJK@1|root,32Z23@2|Bacteria,1VG8I@1239|Firmicutes,24RPX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01543 33035.JPJF01000015_gene4931 9.3e-64 198.0 29VBD@1|root,30GRK@2|Bacteria,1UGHN@1239|Firmicutes,25NZJ@186801|Clostridia,3Y0TT@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01544 33035.JPJF01000015_gene4930 3.31e-91 269.0 2CFUD@1|root,3038G@2|Bacteria,1TTUB@1239|Firmicutes,258DI@186801|Clostridia,3Y0QR@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4860) - - - - - - - - - - - - DUF4860 KKPNOBBG_01545 33035.JPJF01000015_gene4929 8.12e-51 162.0 2E4EX@1|root,2ZVEF@2|Bacteria,1W43C@1239|Firmicutes,2563F@186801|Clostridia,3Y0WS@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01546 33035.JPJF01000015_gene4928 9.39e-173 490.0 COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3XZX3@572511|Blautia 186801|Clostridia NU Type II secretion system (T2SS), protein F gspF - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF KKPNOBBG_01547 33035.JPJF01000015_gene4927 2.14e-210 583.0 COG1305@1|root,COG1305@2|Bacteria,1TP7G@1239|Firmicutes,25KCQ@186801|Clostridia,3XYXN@572511|Blautia 186801|Clostridia E Transglutaminase-like domain - - - - - - - - - - - - Transglut_core KKPNOBBG_01548 33035.JPJF01000015_gene4926 2.78e-98 292.0 COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,3Y08K@572511|Blautia 186801|Clostridia L Psort location CytoplasmicMembrane, score comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB KKPNOBBG_01549 33035.JPJF01000015_gene4925 1.14e-159 447.0 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,3XYMR@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01550 33035.JPJF01000015_gene4924 0.0 897.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3XYXC@572511|Blautia 186801|Clostridia T Psort location CytoplasmicMembrane, score - - 2.7.13.3 ko:K02484 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA KKPNOBBG_01551 33035.JPJF01000015_gene4923 4.38e-209 579.0 COG5401@1|root,COG5401@2|Bacteria,1UXYS@1239|Firmicutes,24EK4@186801|Clostridia,3Y07U@572511|Blautia 186801|Clostridia S Sporulation and spore germination - - - ko:K06298 - - - - ko00000 - - - Germane KKPNOBBG_01552 33035.JPJF01000015_gene4922 0.0 1174.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3XZP4@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B KKPNOBBG_01553 33035.JPJF01000015_gene4921 4.57e-221 611.0 COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,3XZ4T@572511|Blautia 186801|Clostridia L DNA polymerase III, delta' subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta KKPNOBBG_01554 33035.JPJF01000015_gene4920 5.1e-43 141.0 COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,3Y0DB@572511|Blautia 186801|Clostridia J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p KKPNOBBG_01555 33035.JPJF01000015_gene4919 4e-205 568.0 COG0680@1|root,COG0680@2|Bacteria,1TPFY@1239|Firmicutes,248TE@186801|Clostridia,3XYQQ@572511|Blautia 186801|Clostridia C Initiates the rapid degradation of small, acid-soluble proteins during spore germination gpr - 3.4.24.78 ko:K06012 - - - - ko00000,ko01000,ko01002 - - - Peptidase_A25 KKPNOBBG_01556 33035.JPJF01000015_gene4918 5.07e-250 693.0 COG0860@1|root,COG0860@2|Bacteria,1TSFS@1239|Firmicutes,2488U@186801|Clostridia,3XZD8@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 spoIIP - - ko:K06385 - - - - ko00000 - - - SpoIIP KKPNOBBG_01557 33035.JPJF01000015_gene4917 0.0 1163.0 COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3XYYN@572511|Blautia 186801|Clostridia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C KKPNOBBG_01558 33035.JPJF01000067_gene3521 4.98e-250 689.0 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,3XYHD@572511|Blautia 186801|Clostridia H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM KKPNOBBG_01560 33035.JPJF01000067_gene3522 4.21e-100 290.0 COG0517@1|root,COG0517@2|Bacteria,1V7XE@1239|Firmicutes,24HF5@186801|Clostridia,3Y07B@572511|Blautia 186801|Clostridia S COG COG0517 FOG CBS domain - - - - - - - - - - - - CBS KKPNOBBG_01563 33035.JPJF01000067_gene3525 0.0 1828.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3XYNU@572511|Blautia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran KKPNOBBG_01564 33035.JPJF01000067_gene3526 3.77e-226 625.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3XZC7@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl KKPNOBBG_01565 33035.JPJF01000067_gene3527 0.0 1403.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,3XYVD@572511|Blautia 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 KKPNOBBG_01566 33035.JPJF01000067_gene3528 1.96e-135 386.0 COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,3Y06Y@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 comF - - ko:K02242 - M00429 - - ko00000,ko00002,ko02044 - - - Pribosyltran KKPNOBBG_01567 33035.JPJF01000067_gene3529 3e-88 260.0 2DIZ6@1|root,32UC0@2|Bacteria,1VGDB@1239|Firmicutes,24SFK@186801|Clostridia,3Y0CW@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01568 33035.JPJF01000067_gene3530 4.6e-216 600.0 28K89@1|root,2Z9W3@2|Bacteria,1V1PZ@1239|Firmicutes,24D2W@186801|Clostridia,3XZ3Y@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_01569 33035.JPJF01000067_gene3531 5.88e-180 504.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,3XZJU@572511|Blautia 186801|Clostridia S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N KKPNOBBG_01570 33035.JPJF01000067_gene3532 9.67e-227 635.0 COG4856@1|root,COG4856@2|Bacteria,1UZEV@1239|Firmicutes,25CGI@186801|Clostridia,3XYTZ@572511|Blautia 186801|Clostridia S YbbR-like protein - - - - - - - - - - - - YbbR KKPNOBBG_01571 33035.JPJF01000067_gene3533 1.15e-52 166.0 COG1925@1|root,COG1925@2|Bacteria,1VA23@1239|Firmicutes,24N32@186801|Clostridia,3Y0CN@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score - - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr KKPNOBBG_01572 33035.JPJF01000067_gene3534 2.98e-153 432.0 COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,24CRN@186801|Clostridia,3XZSK@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.99 ygaZ - - - - - - - - - - - AzlC KKPNOBBG_01573 33035.JPJF01000067_gene3535 2.41e-56 176.0 COG4392@1|root,COG4392@2|Bacteria,1VAKN@1239|Firmicutes,24N0I@186801|Clostridia,3Y0E3@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - AzlD KKPNOBBG_01574 33035.JPJF01000067_gene3536 5.59e-274 795.0 COG1376@1|root,COG5263@1|root,COG1376@2|Bacteria,COG5263@2|Bacteria,1UVCF@1239|Firmicutes,24BKI@186801|Clostridia,3XZR4@572511|Blautia 186801|Clostridia S L,D-transpeptidase catalytic domain - - - - - - - - - - - - CW_binding_1,YkuD KKPNOBBG_01575 33035.JPJF01000067_gene3537 1.96e-253 700.0 COG0027@1|root,COG0027@2|Bacteria,1VR1C@1239|Firmicutes,25M0G@186801|Clostridia,3XZT7@572511|Blautia 186801|Clostridia F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 KKPNOBBG_01576 1121115.AXVN01000022_gene1728 2.96e-115 343.0 COG0399@1|root,COG0399@2|Bacteria,1TZB6@1239|Firmicutes,249QE@186801|Clostridia,3Y0S8@572511|Blautia 186801|Clostridia M UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - - - - - - - - - - - KKPNOBBG_01577 1123075.AUDP01000009_gene1226 1.02e-161 459.0 COG0463@1|root,COG0463@2|Bacteria,1TRFA@1239|Firmicutes,249CR@186801|Clostridia,3WJSA@541000|Ruminococcaceae 186801|Clostridia M Glycosyl transferase family 2 - - 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 - Glycos_transf_2 KKPNOBBG_01578 476272.RUMHYD_01225 1.84e-45 150.0 COG0697@1|root,COG0697@2|Bacteria,1UHS0@1239|Firmicutes,25FFB@186801|Clostridia,3Y0C7@572511|Blautia 186801|Clostridia EG spore germination - - - - - - - - - - - - EamA KKPNOBBG_01579 1123075.AUDP01000009_gene1228 6.06e-50 160.0 COG2076@1|root,COG2076@2|Bacteria,1VFDI@1239|Firmicutes,24S4I@186801|Clostridia,3WKQ8@541000|Ruminococcaceae 186801|Clostridia P EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_01580 33035.JPJF01000067_gene3539 3.2e-249 686.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,3XZ4N@572511|Blautia 186801|Clostridia E Belongs to the DegT DnrJ EryC1 family wecE - 2.6.1.59 ko:K02805 - - - - ko00000,ko01000,ko01007 - - - DegT_DnrJ_EryC1 KKPNOBBG_01581 33035.JPJF01000067_gene3540 6.99e-263 780.0 COG0860@1|root,COG5263@1|root,COG0860@2|Bacteria,COG5263@2|Bacteria,1V0DN@1239|Firmicutes,24BCJ@186801|Clostridia,3Y28D@572511|Blautia 186801|Clostridia M Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase - - - - - - - - - - - - Amidase_3,CW_binding_1,Glucosaminidase KKPNOBBG_01582 33035.JPJF01000067_gene3541 1.55e-221 679.0 COG2333@1|root,COG5263@1|root,COG2333@2|Bacteria,COG5263@2|Bacteria 2|Bacteria S dextransucrase activity cbpE - - ko:K11063 ko02024,map02024 - - - ko00000,ko00001,ko02042 - - - CW_binding_1,Lactamase_B KKPNOBBG_01583 1410661.JNKW01000006_gene230 6.71e-131 383.0 COG1442@1|root,COG1442@2|Bacteria,1UY89@1239|Firmicutes,249RV@186801|Clostridia 186801|Clostridia M family 8 - - - - - - - - - - - - Cys_rich_CPCC,Glyco_transf_8 KKPNOBBG_01584 742723.HMPREF9477_00065 2.82e-206 577.0 COG0562@1|root,COG0562@2|Bacteria,1TQB9@1239|Firmicutes,249BR@186801|Clostridia,27IA3@186928|unclassified Lachnospiraceae 186801|Clostridia M UDP-galactopyranose mutase glf - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - GLF,NAD_binding_8 KKPNOBBG_01585 1410661.JNKW01000006_gene225 4.05e-132 383.0 COG3475@1|root,COG3475@2|Bacteria,1V0P4@1239|Firmicutes,25B2A@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - ko:K07271 - - - - ko00000,ko01000 - - - LicD KKPNOBBG_01586 1410661.JNKW01000006_gene224 1.71e-152 445.0 COG2244@1|root,COG2244@2|Bacteria,1UYWC@1239|Firmicutes,25CW4@186801|Clostridia 186801|Clostridia S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt KKPNOBBG_01587 1336241.JAEB01000001_gene154 9.15e-108 338.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - 2.7.8.20 ko:K01002,ko:K20534 ko01100,map01100 - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - GT87,Glycos_transf_2 KKPNOBBG_01588 33035.JPJF01000067_gene3546 4.15e-125 360.0 COG1216@1|root,COG1216@2|Bacteria,1TS11@1239|Firmicutes,24BQ6@186801|Clostridia,3Y08Z@572511|Blautia 186801|Clostridia S Glycosyltransferase like family 2 - - 2.4.1.83 ko:K00721,ko:K00786 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2 KKPNOBBG_01589 33035.JPJF01000067_gene3547 6.78e-46 152.0 COG2456@1|root,COG2456@2|Bacteria,1VGMQ@1239|Firmicutes,24NPY@186801|Clostridia,3Y0U7@572511|Blautia 186801|Clostridia S Uncharacterized conserved protein (DUF2304) - - - - - - - - - - - - DUF2304 KKPNOBBG_01590 411461.DORFOR_00958 2.37e-79 271.0 COG4713@1|root,COG4713@2|Bacteria,1UY68@1239|Firmicutes,24A5N@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2142 KKPNOBBG_01591 33035.JPJF01000067_gene3550 5.45e-175 503.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3XZCB@572511|Blautia 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 KKPNOBBG_01592 33035.JPJF01000067_gene3551 8.57e-128 363.0 COG1898@1|root,COG1898@2|Bacteria,1TRVB@1239|Firmicutes,248VX@186801|Clostridia,3XYH7@572511|Blautia 186801|Clostridia G Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose rfbC - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS02630,iHN637.CLJU_RS02745 dTDP_sugar_isom KKPNOBBG_01593 33035.JPJF01000067_gene3552 3.06e-152 431.0 COG1682@1|root,COG1682@2|Bacteria,1TQZF@1239|Firmicutes,248R0@186801|Clostridia,3XZE2@572511|Blautia 186801|Clostridia GM ABC-2 type transporter - - - ko:K09692 ko02010,map02010 M00251 - - ko00000,ko00001,ko00002,ko02000 3.A.1.104 - - ABC2_membrane KKPNOBBG_01594 622312.ROSEINA2194_02599 2.51e-205 580.0 COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia 186801|Clostridia GM ABC-type polysaccharide polyol phosphate transport system ATPase component - - 3.6.3.40 ko:K01990,ko:K09691,ko:K09693 ko02010,map02010 M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C KKPNOBBG_01595 622312.ROSEINA2194_02598 0.0 1201.0 COG0463@1|root,COG1216@1|root,COG3754@1|root,COG0463@2|Bacteria,COG1216@2|Bacteria,COG3754@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 KKPNOBBG_01596 622312.ROSEINA2194_02597 2.08e-145 417.0 COG2242@1|root,COG2242@2|Bacteria,1TPEE@1239|Firmicutes,24D9B@186801|Clostridia 186801|Clostridia H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25 KKPNOBBG_01597 622312.ROSEINA2194_02596 1.82e-62 216.0 COG0030@1|root,COG0030@2|Bacteria,1V28P@1239|Firmicutes 1239|Firmicutes J 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity - - - - - - - - - - - - - KKPNOBBG_01598 33035.JPJF01000067_gene3555 0.0 1107.0 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia,3XYQA@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 KKPNOBBG_01599 33035.JPJF01000067_gene3556 3e-248 692.0 COG1807@1|root,COG1807@2|Bacteria,1V22V@1239|Firmicutes,24GKH@186801|Clostridia,3XYRT@572511|Blautia 186801|Clostridia M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - DUF2142,PMT,PMT_2 KKPNOBBG_01600 33035.JPJF01000067_gene3557 1.19e-210 584.0 COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,248Q5@186801|Clostridia,3XYSZ@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_01601 33035.JPJF01000067_gene3558 0.0 1140.0 COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia,3XYRF@572511|Blautia 186801|Clostridia M Glycosyltransferase like family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 KKPNOBBG_01602 33035.JPJF01000067_gene3559 4.34e-192 536.0 COG1216@1|root,COG1216@2|Bacteria,1TSTE@1239|Firmicutes,249WH@186801|Clostridia,3XYQG@572511|Blautia 186801|Clostridia M Glycosyl transferase family group 2 - - - ko:K07011 - - - - ko00000 - - - Glycos_transf_2 KKPNOBBG_01603 1304866.K413DRAFT_0291 1.51e-194 554.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,36GR6@31979|Clostridiaceae 186801|Clostridia M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - - - - - - - - - - Bac_transf KKPNOBBG_01604 622312.ROSEINA2194_02588 6.02e-92 280.0 COG1215@1|root,COG1215@2|Bacteria,1V1CB@1239|Firmicutes,24EMU@186801|Clostridia 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_01605 929506.CbC4_0708 1.94e-36 143.0 COG3475@1|root,COG3475@2|Bacteria,1VBSV@1239|Firmicutes,24C5H@186801|Clostridia,36EWJ@31979|Clostridiaceae 186801|Clostridia M LICD family licD - - ko:K07271 - - - - ko00000,ko01000 - - - LicD KKPNOBBG_01606 1384065.JAGS01000001_gene2797 4.32e-90 286.0 COG1887@1|root,COG1887@2|Bacteria,1TP75@1239|Firmicutes,24ED0@186801|Clostridia,3WKZI@541000|Ruminococcaceae 186801|Clostridia M CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - 2.7.8.12 ko:K09809 - - - - ko00000,ko01000 - - - Glyphos_transf KKPNOBBG_01607 411489.CLOL250_00069 1.44e-121 353.0 COG1682@1|root,COG1682@2|Bacteria,1V1J2@1239|Firmicutes,25B57@186801|Clostridia,36WAG@31979|Clostridiaceae 186801|Clostridia GM Transport permease protein - - - ko:K01992,ko:K09690 ko02010,map02010 M00250,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 - - ABC2_membrane KKPNOBBG_01608 1232447.BAHW02000008_gene237 3.44e-124 359.0 COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,26AXS@186813|unclassified Clostridiales 186801|Clostridia GM ATPases associated with a variety of cellular activities rfbB - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01609 1235802.C823_02121 1.67e-216 620.0 COG1887@1|root,COG1887@2|Bacteria,1TSTN@1239|Firmicutes,24AA5@186801|Clostridia,25VZJ@186806|Eubacteriaceae 186801|Clostridia M teichoic acid biosynthesis protein B - - 2.7.8.14,2.7.8.47 ko:K18704 - - R11614,R11621 - ko00000,ko01000 - - - Glycos_transf_2,Glyphos_transf KKPNOBBG_01610 1235802.C823_02122 7.41e-136 390.0 COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,25W5N@186806|Eubacteriaceae 186801|Clostridia I Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate - - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD,adh_short KKPNOBBG_01611 1235802.C823_02123 3.8e-133 391.0 COG0451@1|root,COG0451@2|Bacteria,1TS59@1239|Firmicutes,247JP@186801|Clostridia,25W52@186806|Eubacteriaceae 186801|Clostridia GM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase KKPNOBBG_01612 649764.HMPREF0762_01742 8.1e-39 149.0 COG1835@1|root,COG1835@2|Bacteria 2|Bacteria I transferase activity, transferring acyl groups other than amino-acyl groups - - - - - - - - - - - - Acyl_transf_3 KKPNOBBG_01613 411461.DORFOR_00973 1.21e-217 626.0 COG1368@1|root,COG1368@2|Bacteria,1UUVI@1239|Firmicutes,24AGB@186801|Clostridia,27UXQ@189330|Dorea 186801|Clostridia M GBS Bsp-like repeat - - 2.7.8.20 ko:K01002 ko01100,map01100 - - - ko00000,ko01000 - - - GBS_Bsp-like,Sulfatase KKPNOBBG_01614 180332.JTGN01000011_gene649 1.29e-35 135.0 2CJWU@1|root,32SAY@2|Bacteria,1V3P4@1239|Firmicutes,24SCQ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01615 180332.JTGN01000011_gene650 2.18e-55 191.0 2A542@1|root,30TSQ@2|Bacteria,1V4Q2@1239|Firmicutes,24ISW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01618 33035.JPJF01000069_gene4199 1.11e-262 719.0 COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,3XYS9@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase KKPNOBBG_01619 33035.JPJF01000069_gene4198 0.0 2025.0 COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,3XYH9@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,DAP_epimerase,MGS KKPNOBBG_01620 33035.JPJF01000069_gene4197 2.91e-197 548.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3XZFP@572511|Blautia 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA KKPNOBBG_01621 33035.JPJF01000069_gene4196 0.0 1285.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ8B@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_01622 33035.JPJF01000069_gene4195 0.0 885.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 KKPNOBBG_01623 33035.JPJF01000069_gene4194 1.57e-166 468.0 COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia,3Y0H6@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Acetyltransf_7,ThrE KKPNOBBG_01624 33035.JPJF01000069_gene4193 1.94e-95 279.0 COG3610@1|root,COG3610@2|Bacteria,1V6P0@1239|Firmicutes,24R80@186801|Clostridia,3Y0UC@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ThrE_2 KKPNOBBG_01625 33035.JPJF01000069_gene4192 2.42e-210 582.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3XYK8@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase KKPNOBBG_01626 585394.RHOM_13775 1.11e-117 339.0 COG1396@1|root,COG1396@2|Bacteria,1VETP@1239|Firmicutes,25EH8@186801|Clostridia 186801|Clostridia K helix-turn-helix - - - - - - - - - - - - HTH_3 KKPNOBBG_01627 556261.HMPREF0240_01392 1.55e-137 392.0 COG0655@1|root,COG0655@2|Bacteria,1UI36@1239|Firmicutes,247R8@186801|Clostridia,36HCH@31979|Clostridiaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red KKPNOBBG_01628 33035.JPJF01000011_gene1281 7.35e-221 609.0 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,3XYMJ@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_4 KKPNOBBG_01629 33035.JPJF01000011_gene1284 1.11e-195 545.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,3XZ81@572511|Blautia 186801|Clostridia J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS KKPNOBBG_01630 33035.JPJF01000011_gene1285 1.14e-164 461.0 COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,3XYW8@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 KKPNOBBG_01631 33035.JPJF01000011_gene1286 1.01e-176 494.0 COG0657@1|root,COG0657@2|Bacteria,1TP1H@1239|Firmicutes,24D7F@186801|Clostridia,3XYMP@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 KKPNOBBG_01632 33035.JPJF01000011_gene1287 0.0 1281.0 COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,3XZC9@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 fbp - 3.1.3.11 ko:K04041 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_2 KKPNOBBG_01633 33035.JPJF01000011_gene1288 1.64e-164 479.0 COG0841@1|root,COG0841@2|Bacteria,1UUUI@1239|Firmicutes,24UBM@186801|Clostridia 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - Big_3_2 KKPNOBBG_01634 33035.JPJF01000011_gene1289 6.45e-272 757.0 COG0515@1|root,COG0515@2|Bacteria,1TPYP@1239|Firmicutes,24ABN@186801|Clostridia,3Y0GE@572511|Blautia 186801|Clostridia KLT Protein kinase domain - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase KKPNOBBG_01635 33035.JPJF01000011_gene1290 0.0 1128.0 COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,3XZ10@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d KKPNOBBG_01636 33035.JPJF01000011_gene1291 3.58e-191 533.0 COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,248N9@186801|Clostridia,3XYTV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DegV KKPNOBBG_01637 33035.JPJF01000011_gene1292 1.35e-121 349.0 COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia,3Y008@572511|Blautia 186801|Clostridia C LUD domain - - - - - - - - - - - - LUD_dom KKPNOBBG_01638 33035.JPJF01000011_gene1293 2.09e-260 717.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,3XZ33@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_01639 33035.JPJF01000011_gene1294 0.0 1002.0 COG0845@1|root,COG3266@1|root,COG0845@2|Bacteria,COG3266@2|Bacteria,1UZ3U@1239|Firmicutes,24BV7@186801|Clostridia,3XYTA@572511|Blautia 186801|Clostridia M domain, Protein - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 KKPNOBBG_01640 33035.JPJF01000011_gene1295 1.44e-228 642.0 COG0845@1|root,COG0845@2|Bacteria,1V046@1239|Firmicutes,24ANJ@186801|Clostridia,3XYZR@572511|Blautia 186801|Clostridia M Biotin-lipoyl like - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_01641 33035.JPJF01000011_gene1296 1.55e-72 218.0 COG0745@1|root,COG0745@2|Bacteria,1VGRV@1239|Firmicutes,24QZM@186801|Clostridia 186801|Clostridia KT Sporulation initiation factor Spo0A domain protein - - - ko:K07699 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - Spo0A_C KKPNOBBG_01642 394503.Ccel_3225 9.96e-110 328.0 COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,36G1Q@31979|Clostridiaceae 186801|Clostridia H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_01643 180332.JTGN01000018_gene55 5.17e-115 339.0 COG0395@1|root,COG0395@2|Bacteria,1UCH2@1239|Firmicutes,24AS5@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01644 180332.JTGN01000018_gene54 8.48e-104 312.0 COG1175@1|root,COG1175@2|Bacteria,1V2TM@1239|Firmicutes,24H6J@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01645 180332.JTGN01000018_gene53 1.25e-161 472.0 COG1653@1|root,COG1653@2|Bacteria,1TR8U@1239|Firmicutes,25E8A@186801|Clostridia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_01646 537007.BLAHAN_04550 2.26e-152 437.0 COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,24A4D@186801|Clostridia,3XZBK@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 - - 3.2.2.1 ko:K01239 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro KKPNOBBG_01647 1226325.HMPREF1548_03069 1.6e-149 429.0 COG1957@1|root,COG1957@2|Bacteria,1UG03@1239|Firmicutes,24CXS@186801|Clostridia,36GQ0@31979|Clostridiaceae 186801|Clostridia F Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - IU_nuc_hydro KKPNOBBG_01648 742723.HMPREF9477_01712 3.82e-130 380.0 COG1957@1|root,COG1957@2|Bacteria,1TRQQ@1239|Firmicutes,25C8Y@186801|Clostridia,27U3T@186928|unclassified Lachnospiraceae 186801|Clostridia F Inosine-uridine preferring nucleoside hydrolase iunH - 3.2.2.1 ko:K01239,ko:K12700 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro KKPNOBBG_01649 33035.JPJF01000011_gene1304 0.0 1176.0 COG0524@1|root,COG1609@1|root,COG0524@2|Bacteria,COG1609@2|Bacteria,1TQRC@1239|Firmicutes,24BCQ@186801|Clostridia,3XYK9@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - LacI,Peripla_BP_3,PfkB KKPNOBBG_01650 33035.JPJF01000011_gene1305 2.97e-219 610.0 2F32Z@1|root,33VY0@2|Bacteria,1VRWP@1239|Firmicutes,25PV9@186801|Clostridia,3XZBM@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01651 33035.JPJF01000011_gene1307 0.0 1154.0 COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,3XZ1M@572511|Blautia 186801|Clostridia J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon KKPNOBBG_01652 33035.JPJF01000011_gene1308 7.07e-295 805.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,3XYX1@572511|Blautia 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His KKPNOBBG_01653 33035.JPJF01000011_gene1309 8.25e-121 345.0 COG3437@1|root,COG3437@2|Bacteria,1UHZZ@1239|Firmicutes,25E8P@186801|Clostridia 186801|Clostridia KT Psort location Cytoplasmic, score - - - - - - - - - - - - HD,HD_5 KKPNOBBG_01654 33035.JPJF01000011_gene1310 0.0 950.0 COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,3XZ04@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 hemZ - - - - - - - - - - - Radical_SAM KKPNOBBG_01655 33035.JPJF01000011_gene1311 6.93e-147 414.0 COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,3Y04N@572511|Blautia 186801|Clostridia S COG COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B KKPNOBBG_01656 33035.JPJF01000011_gene1312 0.0 1477.0 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,3XZ3M@572511|Blautia 186801|Clostridia KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS16615 ACT_4,HD_4,RelA_SpoT,TGS KKPNOBBG_01657 33035.JPJF01000011_gene1313 9.82e-118 337.0 COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,3XZ59@572511|Blautia 186801|Clostridia F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran KKPNOBBG_01658 33035.JPJF01000011_gene1314 0.0 1075.0 COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3XZHQ@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 KKPNOBBG_01659 33035.JPJF01000011_gene1315 0.0 1315.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,3XYSY@572511|Blautia 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG KKPNOBBG_01660 33035.JPJF01000011_gene1316 0.0 907.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,3XZ42@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 scfB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM KKPNOBBG_01661 411459.RUMOBE_00561 1.06e-19 80.1 2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,3Y0JJ@572511|Blautia 186801|Clostridia S Psort location Extracellular, score 8.82 scfA - - - - - - - - - - - SCIFF KKPNOBBG_01662 33035.JPJF01000011_gene1317 1.93e-70 213.0 2E3KV@1|root,32YJ5@2|Bacteria,1VEHD@1239|Firmicutes,24RP3@186801|Clostridia,3Y0RE@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF3792 KKPNOBBG_01663 33035.JPJF01000011_gene1318 4.24e-251 714.0 2ENTE@1|root,33GEK@2|Bacteria,1VSB4@1239|Firmicutes,24YR1@186801|Clostridia,3XZII@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01664 33035.JPJF01000011_gene1319 8.42e-268 736.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3XZS0@572511|Blautia 186801|Clostridia S COG COG1253 Hemolysins and related proteins containing CBS domains - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 KKPNOBBG_01665 33035.JPJF01000011_gene1320 2.61e-150 425.0 COG5578@1|root,COG5578@2|Bacteria,1V3XD@1239|Firmicutes,24K78@186801|Clostridia,3Y06P@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF624 KKPNOBBG_01666 33035.JPJF01000011_gene1321 1.79e-130 372.0 COG1434@1|root,COG1434@2|Bacteria,1V32X@1239|Firmicutes,24ATY@186801|Clostridia,3XZUF@572511|Blautia 186801|Clostridia S DUF218 domain - - - - - - - - - - - - DUF218 KKPNOBBG_01667 33035.JPJF01000011_gene1322 5.34e-103 300.0 COG1443@1|root,COG1443@2|Bacteria,1V41D@1239|Firmicutes,24P77@186801|Clostridia 186801|Clostridia I NUDIX domain - - - - - - - - - - - - Acetyltransf_7,NUDIX KKPNOBBG_01668 33035.JPJF01000011_gene1323 0.0 1538.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia,3Y17B@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 2 - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_01669 33035.JPJF01000011_gene1324 1.79e-60 186.0 COG2388@1|root,COG2388@2|Bacteria,1VEEX@1239|Firmicutes,24RI0@186801|Clostridia,3Y1Z7@572511|Blautia 186801|Clostridia S GCN5-related N-acetyl-transferase - - - ko:K06975 - - - - ko00000 - - - Acetyltransf_CG KKPNOBBG_01670 33035.JPJF01000011_gene1325 0.0 870.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XYKT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_01671 1298920.KI911353_gene4965 7.33e-43 145.0 COG1846@1|root,COG1846@2|Bacteria,1V9N7@1239|Firmicutes,24NET@186801|Clostridia,220KE@1506553|Lachnoclostridium 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_01672 180332.JTGN01000013_gene951 2.96e-81 248.0 COG2364@1|root,COG2364@2|Bacteria,1UXHA@1239|Firmicutes,24AJQ@186801|Clostridia 186801|Clostridia F Psort location CytoplasmicMembrane, score - - - ko:K07149 - - - - ko00000 - - - Cytidylate_kin2 KKPNOBBG_01673 33035.JPJF01000011_gene1326 6.07e-189 526.0 COG1307@1|root,COG1307@2|Bacteria,1TSKD@1239|Firmicutes,24AE9@186801|Clostridia,3XYU8@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DegV KKPNOBBG_01674 33035.JPJF01000011_gene1327 2.36e-112 323.0 2C2B5@1|root,32RA4@2|Bacteria,1V6P1@1239|Firmicutes,24N51@186801|Clostridia,3Y05S@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01675 33035.JPJF01000011_gene1328 6.37e-207 574.0 29WCP@1|root,30HYB@2|Bacteria,1VV7Y@1239|Firmicutes,250AD@186801|Clostridia,3Y24P@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01676 33035.JPJF01000011_gene1329 1.04e-186 520.0 COG2816@1|root,COG2816@2|Bacteria,1TRMF@1239|Firmicutes,24AXA@186801|Clostridia,3XZJ4@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase KKPNOBBG_01677 33035.JPJF01000011_gene1330 6.52e-149 420.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01678 33035.JPJF01000011_gene1331 0.0 1392.0 COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,25M7M@186801|Clostridia,3Y1DH@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - - - - - - - - - - FtsX KKPNOBBG_01679 33035.JPJF01000011_gene1332 2.24e-194 550.0 COG5002@1|root,COG5002@2|Bacteria,1UHZU@1239|Firmicutes,25E8I@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01680 33035.JPJF01000011_gene1333 2.22e-135 386.0 COG0745@1|root,COG0745@2|Bacteria,1TT71@1239|Firmicutes,24CAY@186801|Clostridia 186801|Clostridia T Response regulator receiver domain protein - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01681 33035.JPJF01000011_gene1334 4.36e-35 120.0 COG1476@1|root,COG1476@2|Bacteria,1VERT@1239|Firmicutes,24QJJ@186801|Clostridia,3Y0N3@572511|Blautia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_01682 33035.JPJF01000011_gene1335 1.76e-44 146.0 2EQKA@1|root,3387H@2|Bacteria,1VJF1@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_01683 33035.JPJF01000011_gene1336 0.0 1287.0 COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,3XZ94@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 KKPNOBBG_01684 33035.JPJF01000011_gene1337 2.14e-149 421.0 COG0500@1|root,COG2226@2|Bacteria,1V9WG@1239|Firmicutes,24JGT@186801|Clostridia,3Y1GH@572511|Blautia 186801|Clostridia Q DREV methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 KKPNOBBG_01685 33035.JPJF01000011_gene1338 9.53e-308 842.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,3XZHG@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score ywdH - 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh KKPNOBBG_01686 33035.JPJF01000011_gene1339 1.35e-51 163.0 2E51P@1|root,32ZV2@2|Bacteria,1VFYG@1239|Firmicutes,24QWN@186801|Clostridia,3Y0D9@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01687 33035.JPJF01000011_gene1340 3.8e-179 499.0 COG0561@1|root,COG0561@2|Bacteria,1V43V@1239|Firmicutes,24AQQ@186801|Clostridia,3XZTP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_3 KKPNOBBG_01688 33035.JPJF01000011_gene1341 9.66e-151 425.0 COG0546@1|root,COG0546@2|Bacteria,1V3YI@1239|Firmicutes,24CRF@186801|Clostridia,3XZXU@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_01689 33035.JPJF01000011_gene1342 1.32e-115 333.0 COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,3Y041@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 maf - - ko:K06287 - - - - ko00000 - - - Maf KKPNOBBG_01690 33035.JPJF01000011_gene1343 1.95e-179 501.0 COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,24PNN@186801|Clostridia 186801|Clostridia S HAD-superfamily hydrolase, subfamily IIB yidA - - - - - - - - - - - Hydrolase_3 KKPNOBBG_01691 33035.JPJF01000011_gene1344 5.77e-26 104.0 2DK69@1|root,308PY@2|Bacteria,1UF6U@1239|Firmicutes,25K7P@186801|Clostridia,3Y1Z6@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01692 33035.JPJF01000011_gene1345 1.71e-162 456.0 COG1116@1|root,COG1116@2|Bacteria,1TSW5@1239|Firmicutes,25AZG@186801|Clostridia,3Y1BI@572511|Blautia 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran KKPNOBBG_01693 33035.JPJF01000011_gene1346 2.36e-220 610.0 COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,3Y0X4@572511|Blautia 186801|Clostridia P NMT1/THI5 like - - - - - - - - - - - - NMT1 KKPNOBBG_01694 33035.JPJF01000011_gene1347 9.85e-162 455.0 COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,25C7Z@186801|Clostridia,3Y16M@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_01695 33035.JPJF01000011_gene1348 7.57e-63 192.0 COG0011@1|root,COG0011@2|Bacteria,1VC4R@1239|Firmicutes,24MY3@186801|Clostridia,3Y1QW@572511|Blautia 186801|Clostridia S Thiamine-binding protein - - - - - - - - - - - - Thiamine_BP KKPNOBBG_01696 33035.JPJF01000011_gene1352 4.25e-312 855.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,3XYXZ@572511|Blautia 186801|Clostridia K COG COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR KKPNOBBG_01697 33035.JPJF01000011_gene1353 0.0 1130.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3XYKW@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C KKPNOBBG_01698 33035.JPJF01000011_gene1354 0.0 1877.0 COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TPR4@1239|Firmicutes,248TM@186801|Clostridia,3XYRC@572511|Blautia 186801|Clostridia C COG COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - 1.97.1.9 ko:K12527 ko00450,map00450 - R07229 RC02420 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2,Pyr_redox_3 KKPNOBBG_01699 33035.JPJF01000011_gene1355 0.0 893.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,3XZEP@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 ssnA - 3.5.4.40 ko:K20810 ko00130,ko01110,map00130,map01110 - R10695 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 KKPNOBBG_01700 33035.JPJF01000011_gene1356 1.78e-97 284.0 COG2050@1|root,COG2050@2|Bacteria,1UI00@1239|Firmicutes,24U68@186801|Clostridia,3Y0GY@572511|Blautia 186801|Clostridia Q Thioesterase superfamily - - - - - - - - - - - - 4HBT KKPNOBBG_01701 33035.JPJF01000011_gene1357 0.0 1207.0 COG1455@1|root,COG2200@1|root,COG1455@2|Bacteria,COG2200@2|Bacteria,1TP8D@1239|Firmicutes,24808@186801|Clostridia,3Y1VT@572511|Blautia 186801|Clostridia G Phosphotransferase system, EIIC - - - - - - - - - - - - EAL,PTS_EIIC KKPNOBBG_01702 33035.JPJF01000011_gene1358 1.11e-153 434.0 COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248GJ@186801|Clostridia,3Y02U@572511|Blautia 186801|Clostridia J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA1 - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 KKPNOBBG_01703 33035.JPJF01000011_gene1359 0.0 917.0 COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,3Y13X@572511|Blautia 186801|Clostridia E Pyridoxal-phosphate dependent enzyme trpB - 4.2.1.20 ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_01706 33035.JPJF01000011_gene1360 5.73e-286 786.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3Y18H@572511|Blautia 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_01707 33035.JPJF01000011_gene1361 5.48e-98 290.0 COG1309@1|root,COG1309@2|Bacteria,1V7DY@1239|Firmicutes,25DSB@186801|Clostridia 186801|Clostridia K WHG domain - - - - - - - - - - - - TetR_N,WHG KKPNOBBG_01708 33035.JPJF01000011_gene1362 5.39e-191 534.0 COG1816@1|root,COG1816@2|Bacteria,1U44B@1239|Firmicutes,247KD@186801|Clostridia,3XYH8@572511|Blautia 186801|Clostridia F Adenosine/AMP deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS13960 A_deaminase KKPNOBBG_01709 33035.JPJF01000011_gene1363 2.59e-277 759.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,3XYUY@572511|Blautia 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS08920 Metalloenzyme KKPNOBBG_01710 33035.JPJF01000011_gene1364 2.5e-177 495.0 COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,3XZ3Q@572511|Blautia 186801|Clostridia F Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis udp - 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 KKPNOBBG_01711 411462.DORLON_01736 2.66e-292 805.0 COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia,27VT6@189330|Dorea 186801|Clostridia M UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - HTH_3,UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N KKPNOBBG_01712 1121115.AXVN01000002_gene1336 7.52e-61 194.0 COG4767@1|root,COG4767@2|Bacteria,1V852@1239|Firmicutes,25BHY@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - VanZ KKPNOBBG_01714 1304880.JAGB01000002_gene2293 6.06e-21 95.9 2DBFE@1|root,2Z8XI@2|Bacteria,1V2DW@1239|Firmicutes,24SKR@186801|Clostridia 186801|Clostridia S Plasmid pRiA4b ORF-3-like protein - - - - - - - - - - - - PRiA4_ORF3 KKPNOBBG_01715 33035.JPJF01000042_gene371 6.46e-218 603.0 COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,24B3A@186801|Clostridia 186801|Clostridia P solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 KKPNOBBG_01716 33035.JPJF01000042_gene372 4.61e-279 771.0 COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,24A64@186801|Clostridia 186801|Clostridia P ABC-type Fe3 transport system permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 KKPNOBBG_01717 33035.JPJF01000042_gene373 6.42e-162 455.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XZ16@572511|Blautia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 KKPNOBBG_01719 33035.JPJF01000042_gene374 2.03e-64 200.0 2BPYC@1|root,32IS4@2|Bacteria,1UI0Z@1239|Firmicutes,25E9Y@186801|Clostridia,3Y0TM@572511|Blautia 186801|Clostridia S VanZ like family - - - - - - - - - - - - VanZ KKPNOBBG_01720 33035.JPJF01000042_gene375 0.0 1197.0 COG1203@1|root,COG1203@2|Bacteria,1TQ9B@1239|Firmicutes,248UE@186801|Clostridia,3Y0VE@572511|Blautia 186801|Clostridia L DEAD/DEAH box helicase cas3 - - ko:K07012 - - - - ko00000,ko01000,ko02048 - - - DEAD,HD,Helicase_C,ResIII KKPNOBBG_01721 33035.JPJF01000042_gene376 2.59e-151 426.0 2DBAF@1|root,2Z82V@2|Bacteria,1TPSR@1239|Firmicutes,24AI1@186801|Clostridia,3Y0ZP@572511|Blautia 186801|Clostridia S CRISPR-associated protein (Cas_Cas5) cas5d - - ko:K19119 - - - - ko00000,ko02048 - - - Cas_Cas5d KKPNOBBG_01722 33035.JPJF01000042_gene377 0.0 1016.0 28HN3@1|root,2Z7WH@2|Bacteria,1TQ7U@1239|Firmicutes,24BMY@186801|Clostridia,3Y11Z@572511|Blautia 186801|Clostridia S CRISPR-associated protein (Cas_Csd1) csd1 - - ko:K19117 - - - - ko00000,ko02048 - - - Cas_Csd1 KKPNOBBG_01723 33035.JPJF01000042_gene378 6.68e-206 570.0 COG3649@1|root,COG3649@2|Bacteria,1TQZ8@1239|Firmicutes,248MT@186801|Clostridia,3Y0ZZ@572511|Blautia 186801|Clostridia L CRISPR-associated protein Cas7 - - - ko:K19118 - - - - ko00000,ko02048 - - - Cas_Cas7 KKPNOBBG_01724 33035.JPJF01000042_gene379 7.91e-143 404.0 COG1468@1|root,COG1468@2|Bacteria,1TT4D@1239|Firmicutes,24B93@186801|Clostridia,3Y1DC@572511|Blautia 186801|Clostridia L Domain of unknown function DUF83 cas4 - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 KKPNOBBG_01725 658086.HMPREF0994_05903 2.13e-205 573.0 COG1518@1|root,COG1518@2|Bacteria,1TQWG@1239|Firmicutes,24889@186801|Clostridia,27KHS@186928|unclassified Lachnospiraceae 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas1 - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 KKPNOBBG_01726 33035.JPJF01000042_gene382 4.6e-63 192.0 COG1343@1|root,COG1343@2|Bacteria,1VAV3@1239|Firmicutes,24NZP@186801|Clostridia,3Y0UB@572511|Blautia 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 KKPNOBBG_01727 33035.JPJF01000009_gene1487 1.62e-30 120.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,3XZE5@572511|Blautia 186801|Clostridia S COG NOG08812 non supervised orthologous group - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_01728 33035.JPJF01000042_gene383 3.11e-41 149.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,3XZE5@572511|Blautia 186801|Clostridia S COG NOG08812 non supervised orthologous group - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_01729 397288.C806_01755 8.08e-32 122.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,27J43@186928|unclassified Lachnospiraceae 186801|Clostridia K Predicted AAA-ATPase - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_01730 33035.JPJF01000042_gene383 7.62e-166 475.0 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia,3XZE5@572511|Blautia 186801|Clostridia S COG NOG08812 non supervised orthologous group - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_01731 33035.JPJF01000042_gene384 8.87e-304 831.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XYX6@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 mepA_2 - - - - - - - - - - - MatE KKPNOBBG_01732 33035.JPJF01000042_gene385 3.5e-167 468.0 COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,3XYMN@572511|Blautia 186801|Clostridia I Psort location plsC_1 - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase KKPNOBBG_01733 33035.JPJF01000042_gene386 0.0 866.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZQF@572511|Blautia 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_01734 33035.JPJF01000042_gene392 1.29e-64 198.0 2DD3J@1|root,32U0T@2|Bacteria,1VB00@1239|Firmicutes,24N49@186801|Clostridia,3Y0BV@572511|Blautia 186801|Clostridia S PrcB C-terminal - - - - - - - - - - - - PrcB_C KKPNOBBG_01735 33035.JPJF01000042_gene393 0.0 993.0 COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,3XYS2@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF3794,LysM KKPNOBBG_01736 33035.JPJF01000042_gene394 2.57e-205 568.0 COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,3XZ86@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N KKPNOBBG_01737 33035.JPJF01000042_gene395 2.87e-146 413.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,3XZAU@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 GntR - - - - - - - - - - - FCD,GntR KKPNOBBG_01738 33035.JPJF01000042_gene396 0.0 937.0 COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,3XZAJ@572511|Blautia 186801|Clostridia EG Psort location CytoplasmicMembrane, score gerA - - ko:K06310 - - - - ko00000 - - - GerA KKPNOBBG_01739 33035.JPJF01000042_gene397 2.62e-240 662.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - - - - - - - - - - Spore_permease KKPNOBBG_01740 33035.JPJF01000042_gene398 3.5e-130 371.0 29WCV@1|root,30HYI@2|Bacteria,1UFR5@1239|Firmicutes,25MHY@186801|Clostridia,3Y1VN@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01741 33035.JPJF01000042_gene399 8.89e-133 379.0 2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia,3Y092@572511|Blautia 186801|Clostridia S Stage II sporulation protein R (spore_II_R) spoIIR - - ko:K06387 - - - - ko00000 - - - Spore_II_R KKPNOBBG_01742 33035.JPJF01000042_gene400 3.01e-186 518.0 COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,3XZR8@572511|Blautia 186801|Clostridia M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race KKPNOBBG_01743 33035.JPJF01000042_gene401 4.93e-100 290.0 COG4506@1|root,COG4506@2|Bacteria,1V8CS@1239|Firmicutes,24JQR@186801|Clostridia,3Y0D5@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 ywiB - - - - - - - - - - - DUF1934 KKPNOBBG_01744 33035.JPJF01000042_gene402 2.36e-74 226.0 2AE00@1|root,313SJ@2|Bacteria,1V6FJ@1239|Firmicutes,24JFA@186801|Clostridia,3Y02Y@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.75 - - - - - - - - - - - - - KKPNOBBG_01745 33035.JPJF01000042_gene403 8.56e-214 598.0 COG0544@1|root,COG0544@2|Bacteria,1V3TE@1239|Firmicutes,24AAA@186801|Clostridia,3Y00S@572511|Blautia 186801|Clostridia M COG COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) tig_1 - - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C KKPNOBBG_01746 33035.JPJF01000042_gene404 0.0 1246.0 COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,248PI@186801|Clostridia,3XZ30@572511|Blautia 186801|Clostridia M penicillin-binding protein 2' pbpC - 3.4.16.4 ko:K05515,ko:K21467 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - MecA_N,PBP_dimer,Transpeptidase KKPNOBBG_01747 33035.JPJF01000042_gene405 2.48e-234 651.0 28IBJ@1|root,2Z8XY@2|Bacteria,1UCWW@1239|Firmicutes,24DUG@186801|Clostridia,3XZIT@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01748 33035.JPJF01000042_gene406 1.14e-82 244.0 2E5KN@1|root,330BS@2|Bacteria,1V5P2@1239|Firmicutes,24TCR@186801|Clostridia,3Y0HH@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01749 33035.JPJF01000042_gene407 5.16e-272 745.0 COG2263@1|root,COG2263@2|Bacteria,1TQUZ@1239|Firmicutes,248AM@186801|Clostridia,3XZ7H@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Methyltransf_32 KKPNOBBG_01750 33035.JPJF01000042_gene408 0.0 1499.0 28IKE@1|root,2Z8M5@2|Bacteria,1TP2B@1239|Firmicutes,248C2@186801|Clostridia,3XYUK@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 GcvP - - - - - - - - - - - Peptidase_C39_2 KKPNOBBG_01751 33035.JPJF01000042_gene409 7.59e-268 733.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,3Y0UP@572511|Blautia 186801|Clostridia E Thermophilic metalloprotease (M29) - - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 KKPNOBBG_01752 33035.JPJF01000042_gene410 8.31e-153 436.0 COG2333@1|root,COG2333@2|Bacteria,1UUV9@1239|Firmicutes,25KC1@186801|Clostridia,3Y1Z0@572511|Blautia 186801|Clostridia S Metallo-beta-lactamase superfamily - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Lactamase_B KKPNOBBG_01753 33035.JPJF01000042_gene411 2.41e-69 213.0 2B6X3@1|root,31ZX0@2|Bacteria,1VH5G@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_01754 33035.JPJF01000042_gene412 2.39e-38 128.0 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,24QPB@186801|Clostridia 186801|Clostridia K DNA-binding helix-turn-helix protein - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_01755 1226325.HMPREF1548_00168 1.71e-268 755.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,36EDH@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_01756 1226325.HMPREF1548_00167 5.9e-174 494.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01757 1226325.HMPREF1548_00165 1.83e-236 660.0 COG1653@1|root,COG1653@2|Bacteria,1UYSZ@1239|Firmicutes,25BW9@186801|Clostridia,36IUA@31979|Clostridiaceae 186801|Clostridia P Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 KKPNOBBG_01758 1226325.HMPREF1548_00164 2.59e-171 483.0 COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia,36WPU@31979|Clostridiaceae 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_01759 1226325.HMPREF1548_00163 5.12e-162 458.0 COG0395@1|root,COG0395@2|Bacteria,1TT5G@1239|Firmicutes,249MU@186801|Clostridia,36GNW@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K17236 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - BPD_transp_1 KKPNOBBG_01760 1449050.JNLE01000003_gene3503 2.25e-218 626.0 COG1053@1|root,COG1053@2|Bacteria,1UM4U@1239|Firmicutes,24AI4@186801|Clostridia,36DHI@31979|Clostridiaceae 186801|Clostridia C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored KKPNOBBG_01761 33035.JPJF01000042_gene413 5.27e-100 291.0 COG1595@1|root,COG1595@2|Bacteria,1V6SV@1239|Firmicutes,24HPR@186801|Clostridia,3Y0EF@572511|Blautia 186801|Clostridia K COG COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_ECF,Sigma70_r2,Sigma70_r4,Sigma70_r4_2 KKPNOBBG_01762 33035.JPJF01000042_gene414 0.0 1119.0 COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,3XZHF@572511|Blautia 186801|Clostridia L COG COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - - - - - - - - - - Beta_propel KKPNOBBG_01763 33035.JPJF01000042_gene415 0.0 925.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,3XZAQ@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 10.00 asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon KKPNOBBG_01764 33035.JPJF01000042_gene416 3.28e-236 651.0 COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,3XZ47@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 KKPNOBBG_01765 33035.JPJF01000042_gene417 2.35e-270 753.0 COG4717@1|root,COG4717@2|Bacteria,1TQP3@1239|Firmicutes,24E0A@186801|Clostridia,3XZEZ@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - AAA_23,AAA_27 KKPNOBBG_01766 33035.JPJF01000042_gene418 0.0 1280.0 COG1874@1|root,COG1874@2|Bacteria,1TT9J@1239|Firmicutes,24CY9@186801|Clostridia,3XZCP@572511|Blautia 186801|Clostridia G Hypothetical glycosyl hydrolase 6 - - - - - - - - - - - - GHL6,Glyco_hydro_42M KKPNOBBG_01767 33035.JPJF01000042_gene419 0.0 1009.0 COG2972@1|root,COG2972@2|Bacteria,1TT1G@1239|Firmicutes,2495G@186801|Clostridia,3Y2A3@572511|Blautia 186801|Clostridia T Cache domain - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_01768 33035.JPJF01000042_gene420 1.24e-239 660.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2PT@1239|Firmicutes,24H78@186801|Clostridia,3Y1TI@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01769 33035.JPJF01000042_gene421 9.75e-298 815.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,3Y0HZ@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_01770 33035.JPJF01000042_gene422 3.83e-199 553.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XZUR@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_01771 33035.JPJF01000042_gene423 8.96e-176 492.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3XZXP@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_01772 33035.JPJF01000042_gene424 1.47e-285 780.0 COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,3XYUR@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N KKPNOBBG_01773 33035.JPJF01000042_gene425 8.39e-223 615.0 COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,3XZ0M@572511|Blautia 186801|Clostridia L DNA replication protein dnaC - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 KKPNOBBG_01774 33035.JPJF01000042_gene426 1.18e-237 656.0 COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,3XYKI@572511|Blautia 186801|Clostridia L primosome component and related proteins dnaD - - - - - - - - - - - DnaB_2 KKPNOBBG_01775 33035.JPJF01000042_gene427 0.0 870.0 COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,3XYHG@572511|Blautia 186801|Clostridia M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M KKPNOBBG_01776 33035.JPJF01000042_gene428 6.66e-282 773.0 COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3XZGS@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase KKPNOBBG_01777 33035.JPJF01000042_gene429 1.96e-254 699.0 COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,3XZRM@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 glgD - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase KKPNOBBG_01778 33035.JPJF01000042_gene430 3.82e-57 177.0 COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,3Y05I@572511|Blautia 186801|Clostridia D Could be involved in septation spoVG - - ko:K06412 - - - - ko00000 - - - SpoVG KKPNOBBG_01779 33035.JPJF01000064_gene3837 1.89e-123 376.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_01780 33035.JPJF01000100_gene3596 2.94e-265 724.0 COG0407@1|root,COG0407@2|Bacteria,1V9U0@1239|Firmicutes,24MDE@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01781 33035.JPJF01000100_gene3595 3.31e-121 348.0 COG0523@1|root,COG0523@2|Bacteria,1V755@1239|Firmicutes,24JV0@186801|Clostridia 186801|Clostridia S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - cobW KKPNOBBG_01783 33035.JPJF01000100_gene3592 0.0 874.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,3XZ2W@572511|Blautia 186801|Clostridia J NOL1 NOP2 sun family protein rsmF - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI KKPNOBBG_01784 33035.JPJF01000100_gene3591 1.13e-216 602.0 COG1609@1|root,COG1609@2|Bacteria,1TPZJ@1239|Firmicutes,248K0@186801|Clostridia 186801|Clostridia K Transcriptional - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_01785 33035.JPJF01000100_gene3590 9.65e-177 497.0 COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia,3XZ37@572511|Blautia 186801|Clostridia S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans KKPNOBBG_01787 33035.JPJF01000009_gene1372 0.0 915.0 COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,3XZA8@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 pepD - - ko:K01270 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 KKPNOBBG_01788 33035.JPJF01000009_gene1373 1.19e-148 421.0 COG0739@1|root,COG0739@2|Bacteria,1TQMQ@1239|Firmicutes,24B3J@186801|Clostridia,3Y0AB@572511|Blautia 186801|Clostridia M COG COG0739 Membrane proteins related to metalloendopeptidases - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 KKPNOBBG_01789 33035.JPJF01000009_gene1374 4.82e-187 520.0 COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,249FE@186801|Clostridia,3XZGG@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yjbM - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT KKPNOBBG_01790 33035.JPJF01000009_gene1375 2.37e-290 797.0 COG0144@1|root,COG3270@1|root,COG0144@2|Bacteria,COG3270@2|Bacteria,1TPGQ@1239|Firmicutes,247N0@186801|Clostridia,3Y16W@572511|Blautia 186801|Clostridia J RNA-binding PUA-like domain of methyltransferase RsmF rsmF - - - - - - - - - - - Methyltr_RsmB-F,Methyltr_RsmF_N,Methyltranf_PUA,RsmF_methylt_CI KKPNOBBG_01791 33035.JPJF01000009_gene1376 7.35e-148 419.0 COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,248HC@186801|Clostridia,3XZSS@572511|Blautia 186801|Clostridia J 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate rsuA - 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 KKPNOBBG_01792 33035.JPJF01000009_gene1377 1.56e-155 437.0 COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24FYY@186801|Clostridia,3XZUV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HAD_2 KKPNOBBG_01793 33035.JPJF01000009_gene1378 0.0 1162.0 COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,3XYGY@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N KKPNOBBG_01794 33035.JPJF01000009_gene1379 9.83e-147 416.0 COG0300@1|root,COG0300@2|Bacteria,1V3UX@1239|Firmicutes,25B0Y@186801|Clostridia,3Y001@572511|Blautia 186801|Clostridia S Enoyl-(Acyl carrier protein) reductase sdh - - ko:K07124 - - - - ko00000 - - - adh_short KKPNOBBG_01795 33035.JPJF01000009_gene1380 1.39e-134 382.0 2E2IE@1|root,32XN3@2|Bacteria,1VD21@1239|Firmicutes,24PNW@186801|Clostridia,3Y2D4@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01796 33035.JPJF01000009_gene1381 2.06e-211 586.0 COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,3XYMC@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 rluC - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 KKPNOBBG_01797 33035.JPJF01000009_gene1382 6.88e-125 355.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,3XZX6@572511|Blautia 186801|Clostridia U Psort location CytoplasmicMembrane, score lepB_1 - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 KKPNOBBG_01798 33035.JPJF01000009_gene1383 8.32e-126 358.0 COG3331@1|root,COG3331@2|Bacteria,1V3S4@1239|Firmicutes,24G7S@186801|Clostridia,3XZTT@572511|Blautia 186801|Clostridia L Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation recU - - ko:K03700 - - - - ko00000,ko03400 - - - RecU KKPNOBBG_01799 33035.JPJF01000009_gene1384 0.0 981.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3XZS3@572511|Blautia 186801|Clostridia S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL KKPNOBBG_01800 33035.JPJF01000009_gene1385 3.98e-129 372.0 COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF975 KKPNOBBG_01801 33035.JPJF01000009_gene1386 5.95e-133 377.0 COG1309@1|root,COG1309@2|Bacteria,1V6JC@1239|Firmicutes,24MPA@186801|Clostridia,3XZXC@572511|Blautia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - TetR_N KKPNOBBG_01802 33035.JPJF01000009_gene1387 9.72e-177 493.0 COG3640@1|root,COG3640@2|Bacteria,1UZHR@1239|Firmicutes,24BYR@186801|Clostridia,3XYW4@572511|Blautia 186801|Clostridia D Anion-transporting ATPase cooC1 - - ko:K07321 - - - - ko00000 - - - AAA_31,CbiA KKPNOBBG_01803 445971.ANASTE_00990 1.2e-32 116.0 COG0640@1|root,COG0640@2|Bacteria,1VFY4@1239|Firmicutes 1239|Firmicutes K ArsR family transcriptional regulator - - - - - - - - - - - - HTH_5 KKPNOBBG_01804 357809.Cphy_1793 1.47e-125 364.0 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,248C8@186801|Clostridia,22452@1506553|Lachnoclostridium 186801|Clostridia S KR domain - - - ko:K07124 - - - - ko00000 - - - adh_short KKPNOBBG_01805 658086.HMPREF0994_00088 6.26e-281 773.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,27J9K@186928|unclassified Lachnospiraceae 186801|Clostridia V MatE effD - - - - - - - - - - - MatE KKPNOBBG_01806 33035.JPJF01000009_gene1388 7.32e-144 407.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,24B5K@186801|Clostridia,3Y1G3@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01807 1232453.BAIF02000085_gene376 3.3e-103 313.0 COG0642@1|root,COG0642@2|Bacteria,1V213@1239|Firmicutes,249E9@186801|Clostridia,26CMM@186813|unclassified Clostridiales 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c KKPNOBBG_01808 33035.JPJF01000009_gene1390 1.32e-169 474.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,3Y1FF@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01809 33035.JPJF01000009_gene1391 0.0 1052.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3Y10W@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_01810 33035.JPJF01000009_gene1392 2.88e-294 803.0 COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,25DH7@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01811 33035.JPJF01000009_gene1393 1.79e-84 252.0 COG1905@1|root,COG1905@2|Bacteria,1VFWQ@1239|Firmicutes,24PUZ@186801|Clostridia,3Y0FI@572511|Blautia 186801|Clostridia C Thioredoxin-like [2Fe-2S] ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx KKPNOBBG_01812 33035.JPJF01000009_gene1394 2.52e-250 690.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3XZNH@572511|Blautia 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH KKPNOBBG_01813 33035.JPJF01000009_gene1395 9.7e-73 219.0 COG4810@1|root,COG4810@2|Bacteria,1VB54@1239|Firmicutes,24JK9@186801|Clostridia,3Y01P@572511|Blautia 186801|Clostridia E BMC pduU - - ko:K04031 - - - - ko00000 - - - BMC KKPNOBBG_01814 33035.JPJF01000009_gene1396 1.71e-89 263.0 COG4917@1|root,COG4917@2|Bacteria,1VAYC@1239|Firmicutes,24F8T@186801|Clostridia,3XZTV@572511|Blautia 186801|Clostridia E Ethanolamine utilisation - propanediol utilisation eutP - - ko:K04029 - - - - ko00000 - - - PduV-EutP KKPNOBBG_01815 33035.JPJF01000009_gene1397 4.08e-307 841.0 COG4819@1|root,COG4819@2|Bacteria,1TQ6T@1239|Firmicutes,24BB7@186801|Clostridia 186801|Clostridia E PFAM Ethanolamine utilisation eutA - - ko:K04019 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001 - - - EutA KKPNOBBG_01816 33035.JPJF01000009_gene1398 2.54e-310 847.0 COG4303@1|root,COG4303@2|Bacteria,1TP15@1239|Firmicutes,248P5@186801|Clostridia 186801|Clostridia E PFAM Ethanolamine ammonia lyase large subunit eutB - 4.3.1.7 ko:K03735 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutB KKPNOBBG_01817 33035.JPJF01000009_gene1399 4.82e-181 507.0 COG4302@1|root,COG4302@2|Bacteria,1TSZM@1239|Firmicutes,24A5Y@186801|Clostridia 186801|Clostridia E Belongs to the EutC family eutC - 4.3.1.7 ko:K03736 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutC KKPNOBBG_01818 33035.JPJF01000009_gene1400 1.01e-143 406.0 COG4816@1|root,COG4816@2|Bacteria,1TPAQ@1239|Firmicutes,248W6@186801|Clostridia 186801|Clostridia E ethanolamine utilization protein eutL - - ko:K04026 - - - - ko00000 - - - BMC KKPNOBBG_01819 33035.JPJF01000009_gene1401 0.0 875.0 COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,25E5E@186801|Clostridia 186801|Clostridia C acetaldehyde dehydrogenase (acetylating) - - - - - - - - - - - - Aldedh KKPNOBBG_01820 33035.JPJF01000009_gene1402 3.05e-60 186.0 COG4577@1|root,COG4577@2|Bacteria,1VA0E@1239|Firmicutes,24N43@186801|Clostridia,3Y09W@572511|Blautia 186801|Clostridia CQ COG COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein - - - ko:K04027 - - - - ko00000 - - - BMC KKPNOBBG_01821 33035.JPJF01000009_gene1403 1.3e-130 372.0 COG4812@1|root,COG4812@2|Bacteria,1V18U@1239|Firmicutes,24D11@186801|Clostridia 186801|Clostridia E Cobalamin adenosyltransferase eutT - 2.5.1.17 ko:K04032 ko00860,ko01100,map00860,map01100 - R01492 RC00533 ko00000,ko00001,ko01000 - - - Cob_adeno_trans KKPNOBBG_01822 33035.JPJF01000009_gene1404 1.09e-138 393.0 COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,3Y0B2@572511|Blautia 186801|Clostridia Q Phosphate propanoyltransferase pduL - - - - - - - - - - - PTAC KKPNOBBG_01823 33035.JPJF01000009_gene1405 4.03e-117 340.0 2E7RK@1|root,3326X@2|Bacteria,1VEHH@1239|Firmicutes,24JHV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01824 33035.JPJF01000009_gene1406 3.38e-51 162.0 COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,24QJA@186801|Clostridia,3Y0FT@572511|Blautia 186801|Clostridia CQ COG COG4576 Carbon dioxide concentrating mechanism carboxysome shell protein - - - ko:K04028 - - - - ko00000 - - - EutN_CcmL KKPNOBBG_01825 33035.JPJF01000009_gene1407 7.44e-232 641.0 COG3192@1|root,COG3192@2|Bacteria,1TNZF@1239|Firmicutes,2483P@186801|Clostridia 186801|Clostridia E PFAM Ethanolamine utilisation protein, EutH eutH - - ko:K04023 - - - - ko00000 - - - EutH KKPNOBBG_01826 33035.JPJF01000009_gene1408 5.07e-98 285.0 COG4766@1|root,COG4766@2|Bacteria,1V498@1239|Firmicutes,25DES@186801|Clostridia 186801|Clostridia E ethanolamine - - - ko:K04030 - - - - ko00000 - - - EutQ KKPNOBBG_01827 33035.JPJF01000009_gene1411 1.34e-178 502.0 COG0719@1|root,COG0719@2|Bacteria,1TQ21@1239|Firmicutes,249IU@186801|Clostridia,3XYP6@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - UPF0051 KKPNOBBG_01828 1235790.C805_00226 2.68e-83 271.0 COG3290@1|root,COG3290@2|Bacteria,1UYTM@1239|Firmicutes,24CUA@186801|Clostridia,25YPA@186806|Eubacteriaceae 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_01829 397290.C810_04109 6.68e-100 298.0 COG3279@1|root,COG3279@2|Bacteria,1V284@1239|Firmicutes,24DT9@186801|Clostridia,27NE1@186928|unclassified Lachnospiraceae 186801|Clostridia K LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_01830 476272.RUMHYD_03205 1.58e-39 137.0 2DP92@1|root,32UKI@2|Bacteria,1VDX7@1239|Firmicutes,24P3B@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01831 1232453.BAIF02000086_gene333 2.11e-103 304.0 COG1309@1|root,COG1309@2|Bacteria,1V3XC@1239|Firmicutes,24JC2@186801|Clostridia 186801|Clostridia K transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N KKPNOBBG_01832 545694.TREPR_1962 5.49e-91 281.0 COG0407@1|root,COG0407@2|Bacteria,2JAKX@203691|Spirochaetes 203691|Spirochaetes H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D KKPNOBBG_01833 1243664.CAVL020000015_gene1843 8.54e-08 63.5 COG2508@1|root,COG2508@2|Bacteria,1TRDF@1239|Firmicutes,4H9KC@91061|Bacilli,1ZCWF@1386|Bacillus 91061|Bacilli QT COG2508 Regulator of polyketide synthase expression pucR_2 - - ko:K09684 - - - - ko00000,ko03000 - - - HTH_30,PucR KKPNOBBG_01834 33035.JPJF01000009_gene1415 3.02e-201 559.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,3Y098@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 9.98 csdA - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4,Fer4_12,Radical_SAM KKPNOBBG_01835 33035.JPJF01000009_gene1416 0.0 1521.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,3XZ5F@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 csdB - 2.3.1.54,4.3.99.4 ko:K00656,ko:K20038 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like KKPNOBBG_01836 33035.JPJF01000009_gene1417 6.76e-198 553.0 COG5464@1|root,COG5464@2|Bacteria,1TYQI@1239|Firmicutes,24D7J@186801|Clostridia,3Y26P@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Transposase_31 KKPNOBBG_01837 33035.JPJF01000009_gene1418 8.15e-288 790.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XZGC@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_01838 357809.Cphy_0940 3.33e-24 99.4 COG1595@1|root,COG1595@2|Bacteria,1VCIR@1239|Firmicutes,24NX6@186801|Clostridia,22388@1506553|Lachnoclostridium 186801|Clostridia K Sigma-70 region 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 KKPNOBBG_01840 1540257.JQMW01000011_gene2280 3.13e-110 328.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,36DUN@31979|Clostridiaceae 186801|Clostridia V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01841 796942.HMPREF9623_01356 1.4e-41 159.0 COG1277@1|root,COG1277@2|Bacteria,1UTUG@1239|Firmicutes,25EAK@186801|Clostridia 186801|Clostridia S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - ABC2_membrane_2,ABC2_membrane_3 KKPNOBBG_01843 33035.JPJF01000009_gene1421 1.03e-266 732.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,3Y1A6@572511|Blautia 186801|Clostridia EK Alanine-glyoxylate amino-transferase - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 KKPNOBBG_01844 33035.JPJF01000009_gene1422 0.0 899.0 COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia 186801|Clostridia K aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2,GntR KKPNOBBG_01845 658086.HMPREF0994_00687 6.97e-98 297.0 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,27J2J@186928|unclassified Lachnospiraceae 186801|Clostridia P Cation efflux family - - - - - - - - - - - - Cation_efflux,ZT_dimer KKPNOBBG_01846 1298920.KI911353_gene2479 1.69e-61 198.0 COG1846@1|root,COG1846@2|Bacteria,1VBKX@1239|Firmicutes,24I4R@186801|Clostridia,220T8@1506553|Lachnoclostridium 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR KKPNOBBG_01847 33035.JPJF01000009_gene1424 1.41e-97 285.0 COG0454@1|root,COG0456@2|Bacteria,1UHZS@1239|Firmicutes,25E8H@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_01848 1121334.KB911069_gene1462 3.03e-248 686.0 COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia,3WK5V@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 KKPNOBBG_01849 1105031.HMPREF1141_1070 1.58e-66 204.0 COG1786@1|root,COG1786@2|Bacteria,1V4V4@1239|Firmicutes,24I6P@186801|Clostridia,36RXC@31979|Clostridiaceae 186801|Clostridia S Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 KKPNOBBG_01850 1487921.DP68_18170 1.06e-79 254.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,36VS7@31979|Clostridiaceae 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_01851 1487921.DP68_18165 2.32e-36 130.0 COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,24HA7@186801|Clostridia,36PE8@31979|Clostridiaceae 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ KKPNOBBG_01852 742740.HMPREF9474_03014 1.3e-171 494.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,21ZGS@1506553|Lachnoclostridium 186801|Clostridia G COG COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM,DctQ KKPNOBBG_01853 742740.HMPREF9474_01625 2.27e-191 543.0 COG2768@1|root,COG2768@2|Bacteria,1TPRV@1239|Firmicutes,247PJ@186801|Clostridia,21Z0M@1506553|Lachnoclostridium 186801|Clostridia C Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088,DUF362 KKPNOBBG_01854 1123075.AUDP01000004_gene873 5.21e-124 365.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3WP2Y@541000|Ruminococcaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_01855 1487921.DP68_18175 1.28e-44 155.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,36IAW@31979|Clostridiaceae 186801|Clostridia K GntR family - - - - - - - - - - - - FCD,GntR KKPNOBBG_01856 33035.JPJF01000009_gene1425 3.91e-194 543.0 COG1680@1|root,COG1680@2|Bacteria,1W747@1239|Firmicutes,256Q7@186801|Clostridia,3Y0WX@572511|Blautia 186801|Clostridia V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase KKPNOBBG_01857 33035.JPJF01000009_gene1426 2.19e-151 431.0 COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TTBG@1239|Firmicutes,24CWB@186801|Clostridia,3Y13J@572511|Blautia 186801|Clostridia KT Bacterial transcription activator, effector binding domain - - - - - - - - - - - - GyrI-like,MerR_1 KKPNOBBG_01858 33035.JPJF01000009_gene1430 0.0 1375.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3XYNU@572511|Blautia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran KKPNOBBG_01859 33035.JPJF01000009_gene1446 1.25e-171 481.0 COG2169@1|root,COG4977@1|root,COG2169@2|Bacteria,COG4977@2|Bacteria,1UHZV@1239|Firmicutes,25E8J@186801|Clostridia,3Y12E@572511|Blautia 186801|Clostridia F AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_01860 33035.JPJF01000009_gene1447 0.0 1308.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3XYX5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_01861 33035.JPJF01000009_gene1452 7.51e-34 126.0 COG0500@1|root,COG3153@1|root,COG0500@2|Bacteria,COG3153@2|Bacteria,1UHZW@1239|Firmicutes,25E8K@186801|Clostridia 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 KKPNOBBG_01862 556261.HMPREF0240_03387 1.94e-106 316.0 COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,24B08@186801|Clostridia,36G4J@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 KKPNOBBG_01863 1203606.HMPREF1526_00577 0.0 1464.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase KKPNOBBG_01864 1158607.UAU_01631 9.34e-36 131.0 COG0454@1|root,COG0456@2|Bacteria,1TVMD@1239|Firmicutes,4IA4R@91061|Bacilli,4B53Q@81852|Enterococcaceae 91061|Bacilli K acetyltransferase - - - - - - - - - - - - - KKPNOBBG_01865 180332.JTGN01000011_gene515 3.23e-100 296.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249J2@186801|Clostridia 186801|Clostridia P Psort location Cytoplasmic, score - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N KKPNOBBG_01866 1226325.HMPREF1548_03810 2.34e-218 616.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36FGY@31979|Clostridiaceae 186801|Clostridia P Cation transport protein ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH KKPNOBBG_01867 1235790.C805_02660 0.00071 45.8 2DQVA@1|root,338WD@2|Bacteria,1VFDP@1239|Firmicutes,24RCA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01868 33035.JPJF01000009_gene1460 3.53e-143 407.0 COG0789@1|root,COG0789@2|Bacteria,1TQ78@1239|Firmicutes,247ZI@186801|Clostridia,3XZ8J@572511|Blautia 186801|Clostridia K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 KKPNOBBG_01869 33035.JPJF01000009_gene1461 1.44e-149 423.0 COG1131@1|root,COG1131@2|Bacteria,1TQTX@1239|Firmicutes,249W1@186801|Clostridia,3XZ4S@572511|Blautia 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01870 33035.JPJF01000009_gene1462 1.42e-146 416.0 COG0842@1|root,COG0842@2|Bacteria,1TPZY@1239|Firmicutes,2482T@186801|Clostridia,3XZQ7@572511|Blautia 186801|Clostridia V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane KKPNOBBG_01871 33035.JPJF01000009_gene1463 5.54e-101 296.0 COG4430@1|root,COG4430@2|Bacteria,1V1VF@1239|Firmicutes,249ZH@186801|Clostridia 186801|Clostridia S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA KKPNOBBG_01872 1280681.AUJZ01000005_gene3202 1.08e-130 376.0 COG0030@1|root,COG0030@2|Bacteria,1TPC0@1239|Firmicutes,24ADN@186801|Clostridia,4BWTP@830|Butyrivibrio 186801|Clostridia J Ribosomal RNA adenine dimethylase - - - - - - - - - - - - Methyltransf_11,RrnaAD KKPNOBBG_01873 33035.JPJF01000009_gene1477 1.1e-98 290.0 COG0350@1|root,COG0350@2|Bacteria,1V2MB@1239|Firmicutes,24HJ0@186801|Clostridia 186801|Clostridia L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N KKPNOBBG_01874 33035.JPJF01000009_gene1478 6.49e-123 351.0 COG0655@1|root,COG0655@2|Bacteria,1V1FU@1239|Firmicutes,24FWC@186801|Clostridia 186801|Clostridia S PFAM NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red KKPNOBBG_01875 553973.CLOHYLEM_05164 1.44e-191 539.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,21YE1@1506553|Lachnoclostridium 186801|Clostridia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,Rhodanese,SelR KKPNOBBG_01877 658086.HMPREF0994_05658 0.0 1009.0 COG0737@1|root,COG1653@1|root,COG0737@2|Bacteria,COG1653@2|Bacteria,1UW4I@1239|Firmicutes,25KQK@186801|Clostridia,27SXV@186928|unclassified Lachnospiraceae 186801|Clostridia FG Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_01878 658086.HMPREF0994_05657 0.0 1217.0 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27UFD@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PocR,Response_reg KKPNOBBG_01879 748727.CLJU_c00820 9.96e-134 382.0 COG0745@1|root,COG0745@2|Bacteria,1TSCM@1239|Firmicutes,248K7@186801|Clostridia,36FU9@31979|Clostridiaceae 186801|Clostridia KT response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01880 748727.CLJU_c00810 8.28e-166 469.0 COG5002@1|root,COG5002@2|Bacteria,1UIAP@1239|Firmicutes,25EFU@186801|Clostridia,36UP8@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01881 1122918.KB907267_gene12 3.67e-188 526.0 COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,4HAGA@91061|Bacilli,274EC@186822|Paenibacillaceae 91061|Bacilli V Bacitracin ABC transporter, ATP-binding protein potA3 - - ko:K01990,ko:K19309 ko02010,map02010 M00254,M00747 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.131.1 - - ABC_tran KKPNOBBG_01882 272563.CD630_03170 2.23e-114 334.0 COG4200@1|root,COG4200@2|Bacteria,1V0P5@1239|Firmicutes,24BU1@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K19310 ko02010,map02010 M00747 - - ko00000,ko00001,ko00002,ko02000 3.A.1.131.1 - - ABC2_membrane_4 KKPNOBBG_01883 536227.CcarbDRAFT_2079 9.78e-113 330.0 COG4200@1|root,COG4200@2|Bacteria,1UY6Y@1239|Firmicutes,25EWV@186801|Clostridia,36HS2@31979|Clostridiaceae 186801|Clostridia S ABC-2 family transporter protein - - - ko:K19310 ko02010,map02010 M00747 - - ko00000,ko00001,ko00002,ko02000 3.A.1.131.1 - - ABC2_membrane_4 KKPNOBBG_01884 1211844.CBLM010000017_gene1444 1.46e-104 336.0 COG0584@1|root,COG4781@1|root,COG0584@2|Bacteria,COG4781@2|Bacteria,1UGF1@1239|Firmicutes,3VQNH@526524|Erysipelotrichia 526524|Erysipelotrichia C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,GPDPase_memb KKPNOBBG_01885 457421.CBFG_05529 1.75e-141 402.0 COG0745@1|root,COG0745@2|Bacteria,1TPRM@1239|Firmicutes,25B4D@186801|Clostridia,26B27@186813|unclassified Clostridiales 186801|Clostridia KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_01886 457421.CBFG_05527 7.38e-196 557.0 COG0642@1|root,COG2205@2|Bacteria,1TS12@1239|Firmicutes,24AAW@186801|Clostridia,26A1A@186813|unclassified Clostridiales 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_01887 457421.CBFG_05526 0.0 1149.0 COG0577@1|root,COG0577@2|Bacteria,1TRE5@1239|Firmicutes,24CGY@186801|Clostridia 186801|Clostridia V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_01888 457421.CBFG_05525 7.18e-129 370.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01889 469596.HMPREF9488_01204 2.53e-143 411.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,3VPWI@526524|Erysipelotrichia 526524|Erysipelotrichia K Bacterial transcription activator, effector binding domain - - - - - - - - - - - - Cass2,HTH_18 KKPNOBBG_01890 908340.HMPREF9406_3318 3.05e-76 230.0 COG4978@1|root,COG4978@2|Bacteria,1V5CV@1239|Firmicutes,24HXP@186801|Clostridia,36J8S@31979|Clostridiaceae 186801|Clostridia KT GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like KKPNOBBG_01891 37659.JNLN01000001_gene1473 4.89e-142 410.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36ER8@31979|Clostridiaceae 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 KKPNOBBG_01892 33035.JPJF01000021_gene3331 3.3e-108 319.0 COG0842@1|root,COG0842@2|Bacteria,1TSWD@1239|Firmicutes,24DHH@186801|Clostridia,3Y0TH@572511|Blautia 186801|Clostridia V ABC-2 type transporter yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane KKPNOBBG_01893 1226325.HMPREF1548_05884 9.8e-122 352.0 COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia,36I6U@31979|Clostridiaceae 186801|Clostridia V ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_01894 1226325.HMPREF1548_05883 9.66e-154 454.0 2F5WY@1|root,3088A@2|Bacteria,1U2ZR@1239|Firmicutes,24TGE@186801|Clostridia,36N8I@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01895 1226325.HMPREF1548_05881 6.69e-98 293.0 2EFXP@1|root,339PX@2|Bacteria,1VMW2@1239|Firmicutes,24P3U@186801|Clostridia,36KKZ@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01896 1226325.HMPREF1548_05880 1.09e-151 444.0 COG3290@1|root,COG3290@2|Bacteria,1VAQD@1239|Firmicutes,24E6D@186801|Clostridia,36J2F@31979|Clostridiaceae 186801|Clostridia T PFAM ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HATPase_c_5,SPOB_a KKPNOBBG_01897 1226325.HMPREF1548_05879 1.05e-104 310.0 COG3279@1|root,COG3279@2|Bacteria,1VC32@1239|Firmicutes,24EU4@186801|Clostridia,36JQM@31979|Clostridiaceae 186801|Clostridia T response regulator, receiver - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_01898 526218.Sterm_0501 6.1e-204 571.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds ybaC - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1,Hydrolase_4 KKPNOBBG_01899 545695.TREAZ_2608 9.32e-87 262.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator yfiR - - ko:K21962 - - - - ko00000,ko03000 - - - TetR_N KKPNOBBG_01900 1226325.HMPREF1548_04022 2.48e-116 335.0 COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,24CNE@186801|Clostridia,36JRF@31979|Clostridiaceae 186801|Clostridia E PFAM Lysine exporter protein (LYSE YGGA) - - - ko:K11249 - - - - ko00000,ko02000 2.A.76.1.4 - - LysE KKPNOBBG_01901 1226325.HMPREF1548_04024 4.56e-116 335.0 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V5G6@1239|Firmicutes,24928@186801|Clostridia,36GWJ@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix domain protein - - - - - - - - - - - - Cupin_2,HTH_3 KKPNOBBG_01902 658086.HMPREF0994_00187 3.02e-67 205.0 COG1733@1|root,COG1733@2|Bacteria,1V70C@1239|Firmicutes,24HID@186801|Clostridia,27MS8@186928|unclassified Lachnospiraceae 186801|Clostridia K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR KKPNOBBG_01903 658086.HMPREF0994_00186 1.06e-86 256.0 COG3871@1|root,COG3871@2|Bacteria,1V6IU@1239|Firmicutes,24G5S@186801|Clostridia,27N8Q@186928|unclassified Lachnospiraceae 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase like - - - - - - - - - - - - Putative_PNPOx,Pyrid_ox_like KKPNOBBG_01904 556261.HMPREF0240_02203 3.35e-58 188.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,36EDW@31979|Clostridiaceae 186801|Clostridia K transcription activator, effector binding - - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 KKPNOBBG_01905 411490.ANACAC_01173 2.26e-85 255.0 COG3708@1|root,COG3708@2|Bacteria,1V29U@1239|Firmicutes,24GZS@186801|Clostridia 186801|Clostridia K Bacterial transcription activator, effector binding domain - - - - - - - - - - - - Cass2 KKPNOBBG_01906 1123075.AUDP01000004_gene839 1.5e-131 381.0 COG0789@1|root,COG0789@2|Bacteria,1TQYF@1239|Firmicutes,25B18@186801|Clostridia,3WIBA@541000|Ruminococcaceae 186801|Clostridia K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1,TipAS KKPNOBBG_01907 1235802.C823_06156 4.26e-158 444.0 COG4422@1|root,COG4422@2|Bacteria,1TPP1@1239|Firmicutes,248RZ@186801|Clostridia,25W5Q@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF4186,DUF5131 KKPNOBBG_01908 457421.CBFG_00332 6.79e-87 257.0 COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia 186801|Clostridia J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def2 - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase KKPNOBBG_01909 457421.CBFG_00331 1.65e-38 130.0 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,24QPB@186801|Clostridia 186801|Clostridia K DNA-binding helix-turn-helix protein - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_19,HTH_3 KKPNOBBG_01910 33035.JPJF01000048_gene690 1.55e-93 275.0 29299@1|root,2ZPTU@2|Bacteria,1V5UQ@1239|Firmicutes,24I5P@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_01913 553973.CLOHYLEM_06393 8.02e-132 379.0 COG0500@1|root,COG2226@2|Bacteria,1UVHG@1239|Firmicutes,25KIB@186801|Clostridia,221KJ@1506553|Lachnoclostridium 186801|Clostridia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 KKPNOBBG_01914 553973.CLOHYLEM_04103 2.32e-95 282.0 2BXP4@1|root,2ZBZG@2|Bacteria,1V1ZR@1239|Firmicutes,24GRV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01915 1226325.HMPREF1548_03201 1.52e-151 430.0 COG0500@1|root,COG0500@2|Bacteria,1UHZW@1239|Firmicutes,25E8K@186801|Clostridia,36V9J@31979|Clostridiaceae 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 KKPNOBBG_01917 1345695.CLSA_c34670 5.21e-81 243.0 COG1670@1|root,COG1670@2|Bacteria,1V6M5@1239|Firmicutes,249V4@186801|Clostridia,36GQZ@31979|Clostridiaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 KKPNOBBG_01918 411902.CLOBOL_04625 2.89e-134 382.0 COG4845@1|root,COG4845@2|Bacteria,1V9NV@1239|Firmicutes,24FCQ@186801|Clostridia,21Y0Q@1506553|Lachnoclostridium 186801|Clostridia V Chloramphenicol acetyltransferase - - 2.3.1.28 ko:K19271 - - - - br01600,ko00000,ko01000,ko01504 - - - CAT KKPNOBBG_01919 272563.CD630_17210 2.66e-95 281.0 COG3797@1|root,COG3797@2|Bacteria,1UY7E@1239|Firmicutes,25CR1@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 KKPNOBBG_01920 553973.CLOHYLEM_06392 2.93e-173 486.0 COG1357@1|root,COG1357@2|Bacteria,1TR7Y@1239|Firmicutes,2482A@186801|Clostridia,22289@1506553|Lachnoclostridium 186801|Clostridia S Pentapeptide repeats (8 copies) - - - - - - - - - - - - Pentapeptide KKPNOBBG_01921 1410624.JNKK01000013_gene1496 6.56e-36 130.0 COG3153@1|root,COG5470@1|root,COG3153@2|Bacteria,COG5470@2|Bacteria,1V3PW@1239|Firmicutes,24ACS@186801|Clostridia,27IX9@186928|unclassified Lachnospiraceae 186801|Clostridia S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7,Acetyltransf_9 KKPNOBBG_01922 1540257.JQMW01000004_gene355 3.89e-90 271.0 2E2I5@1|root,32XMX@2|Bacteria,1VC1W@1239|Firmicutes,24H3A@186801|Clostridia,36I8E@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01923 658086.HMPREF0994_00188 4.74e-259 718.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,249Q3@186801|Clostridia,27JE6@186928|unclassified Lachnospiraceae 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_01924 411902.CLOBOL_02911 6.5e-303 836.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,222E9@1506553|Lachnoclostridium 186801|Clostridia S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn KKPNOBBG_01925 411902.CLOBOL_02912 2.57e-132 377.0 COG0110@1|root,COG0110@2|Bacteria,1TPKX@1239|Firmicutes,249X2@186801|Clostridia,21ZGM@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 9.65 vat - - ko:K18234 - - - - ko00000,ko01000,ko01504 - - - Hexapep KKPNOBBG_01926 457421.CBFG_02539 3.42e-302 829.0 COG2186@1|root,COG2186@2|Bacteria,1TSP3@1239|Firmicutes,24DQE@186801|Clostridia 186801|Clostridia K Transcriptional regulator, GntR family - - - - - - - - - - - - GntR KKPNOBBG_01927 428126.CLOSPI_00716 7.92e-139 398.0 COG1409@1|root,COG1409@2|Bacteria,1TT7M@1239|Firmicutes 1239|Firmicutes S Carbohydrate esterase, sialic acid-specific acetylesterase - - - - - - - - - - - - SASA KKPNOBBG_01928 658086.HMPREF0994_04440 0.0 1781.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,27I78@186928|unclassified Lachnospiraceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9,Response_reg KKPNOBBG_01929 658086.HMPREF0994_04439 0.0 1207.0 COG2200@1|root,COG2203@1|root,COG2200@2|Bacteria,COG2203@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,27UDW@186928|unclassified Lachnospiraceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF KKPNOBBG_01930 553973.CLOHYLEM_07190 0.0 2392.0 COG5001@1|root,COG5001@2|Bacteria,1UK1A@1239|Firmicutes,25FH2@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF KKPNOBBG_01931 1151292.QEW_3981 7.16e-92 271.0 COG5423@1|root,COG5423@2|Bacteria,1UQP8@1239|Firmicutes 1239|Firmicutes M Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284,Dimerisation2,Methyltransf_2 KKPNOBBG_01933 1232449.BAHV02000011_gene2161 1.9e-216 603.0 COG4335@1|root,COG4335@2|Bacteria,1TRE4@1239|Firmicutes,24A2G@186801|Clostridia 186801|Clostridia L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation KKPNOBBG_01934 742733.HMPREF9469_01162 1.02e-116 337.0 COG0693@1|root,COG0693@2|Bacteria,1V1TX@1239|Firmicutes,25CHM@186801|Clostridia,22495@1506553|Lachnoclostridium 186801|Clostridia S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI KKPNOBBG_01935 658086.HMPREF0994_05788 3.61e-153 435.0 COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia 186801|Clostridia C nitroreductase - - - - - - - - - - - - DUF1905,Nitroreductase KKPNOBBG_01936 457421.CBFG_00178 3.27e-92 271.0 COG3554@1|root,COG3554@2|Bacteria,1V3D8@1239|Firmicutes,24HRC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01937 658086.HMPREF0994_04759 1.03e-64 206.0 2EWIX@1|root,33PX4@2|Bacteria,1VQVY@1239|Firmicutes 1239|Firmicutes S Protein of unknown function with HXXEE motif - - - - - - - - - - - - HXXEE KKPNOBBG_01938 658659.HMPREF0983_02170 1.29e-39 140.0 COG1309@1|root,COG1309@2|Bacteria,1W1AQ@1239|Firmicutes 1239|Firmicutes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - - KKPNOBBG_01939 1123075.AUDP01000007_gene2794 0.0 1290.0 COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,25B73@186801|Clostridia,3WS92@541000|Ruminococcaceae 186801|Clostridia K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE KKPNOBBG_01940 1211844.CBLM010000143_gene3102 5.96e-98 347.0 COG4886@1|root,COG4886@2|Bacteria,1V3DU@1239|Firmicutes,3VRAR@526524|Erysipelotrichia 526524|Erysipelotrichia M Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - KKPNOBBG_01942 411469.EUBHAL_02428 2.42e-113 343.0 COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia,25X5H@186806|Eubacteriaceae 186801|Clostridia QT Purine catabolism regulatory protein-like family - - - - - - - - - - - - HTH_30,PucR KKPNOBBG_01943 1196322.A370_02993 2.39e-255 708.0 COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae 186801|Clostridia E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - iHN637.CLJU_RS10045 Aminotran_3 KKPNOBBG_01944 1410630.JNKP01000003_gene916 2.77e-257 709.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,27IMB@186928|unclassified Lachnospiraceae 186801|Clostridia E Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 KKPNOBBG_01945 1064535.MELS_1206 1.06e-82 250.0 COG1102@1|root,COG1102@2|Bacteria,1V74C@1239|Firmicutes,4H50S@909932|Negativicutes 909932|Negativicutes F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_01946 33905.BTHE_0875 0.0 1135.0 COG0531@1|root,COG1454@1|root,COG0531@2|Bacteria,COG1454@2|Bacteria,2GJ75@201174|Actinobacteria,4D03M@85004|Bifidobacteriales 201174|Actinobacteria CE Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2,Fe-ADH,Usp KKPNOBBG_01947 877411.JMMA01000002_gene1069 6.23e-18 82.4 COG0317@1|root,COG0317@2|Bacteria,1TQW3@1239|Firmicutes,2483C@186801|Clostridia,3WH98@541000|Ruminococcaceae 186801|Clostridia KT Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT KKPNOBBG_01948 1195236.CTER_1695 0.0 972.0 COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,3WH69@541000|Ruminococcaceae 186801|Clostridia C TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit cooS - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Prismane KKPNOBBG_01949 1514668.JOOA01000001_gene768 2.11e-101 307.0 COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,24A1D@186801|Clostridia,3WICD@541000|Ruminococcaceae 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 KKPNOBBG_01950 1195236.CTER_1697 2.32e-93 282.0 COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,3WGZB@541000|Ruminococcaceae 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport system permease component - - - ko:K02050,ko:K15552 ko00920,ko02010,map00920,map02010 M00188,M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4 - - BPD_transp_1 KKPNOBBG_01951 1291050.JAGE01000001_gene3000 2.83e-116 340.0 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,3WHGU@541000|Ruminococcaceae 186801|Clostridia P ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran KKPNOBBG_01953 1226325.HMPREF1548_00271 5.64e-131 392.0 COG3452@1|root,COG5001@1|root,COG3452@2|Bacteria,COG5001@2|Bacteria,1VRUY@1239|Firmicutes,25EFD@186801|Clostridia,36UNW@31979|Clostridiaceae 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF KKPNOBBG_01955 397290.C810_01644 3.72e-141 401.0 COG1600@1|root,COG1600@2|Bacteria,1UFJF@1239|Firmicutes,24GR0@186801|Clostridia,27I5P@186928|unclassified Lachnospiraceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 KKPNOBBG_01956 556261.HMPREF0240_01373 2.59e-136 389.0 COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae 186801|Clostridia M Belongs to the aspartate glutamate racemases family - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS14520 Asp_Glu_race KKPNOBBG_01957 742733.HMPREF9469_01757 3.68e-182 541.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,21Y40@1506553|Lachnoclostridium 186801|Clostridia NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 KKPNOBBG_01960 457421.CBFG_01058 2.15e-253 700.0 COG2199@1|root,COG2199@2|Bacteria,1UJ6U@1239|Firmicutes,25EX2@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF KKPNOBBG_01961 457421.CBFG_01057 1.13e-204 576.0 COG2199@1|root,COG2199@2|Bacteria,1VDB3@1239|Firmicutes,24MBC@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF KKPNOBBG_01962 457421.CBFG_05444 1.55e-77 238.0 COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,2682M@186813|unclassified Clostridiales 186801|Clostridia O Cytochrome C biogenesis protein transmembrane region ccdA - - ko:K06196 - - - - ko00000,ko02000 5.A.1.2 - - DsbD KKPNOBBG_01963 411902.CLOBOL_01645 1.05e-78 240.0 COG0526@1|root,COG0526@2|Bacteria,1V52A@1239|Firmicutes 1239|Firmicutes CO COG0526, thiol-disulfide isomerase and thioredoxins tlpA - - - - - - - - - - - AhpC-TSA,Redoxin KKPNOBBG_01964 553973.CLOHYLEM_05164 4.36e-247 681.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,21YE1@1506553|Lachnoclostridium 186801|Clostridia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,Rhodanese,SelR KKPNOBBG_01965 553973.CLOHYLEM_05163 1.13e-158 447.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1U766@1239|Firmicutes,25BKB@186801|Clostridia,223U4@1506553|Lachnoclostridium 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_01966 553973.CLOHYLEM_05162 0.0 957.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,21XTZ@1506553|Lachnoclostridium 186801|Clostridia T signal transduction protein with a C-terminal ATPase domain - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_01967 411902.CLOBOL_03012 1.89e-86 255.0 COG0346@1|root,COG0346@2|Bacteria,1V6CB@1239|Firmicutes,24INJ@186801|Clostridia,22149@1506553|Lachnoclostridium 186801|Clostridia E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase KKPNOBBG_01968 1341157.RF007C_13270 2.38e-25 103.0 2F8I8@1|root,340X1@2|Bacteria,1VYD1@1239|Firmicutes,24SXY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01969 1211844.CBLM010000111_gene2141 6.62e-80 240.0 COG1396@1|root,COG1396@2|Bacteria,1V9BA@1239|Firmicutes,3VRPQ@526524|Erysipelotrichia 526524|Erysipelotrichia K Helix-turn-helix domain - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_01970 658659.HMPREF0983_02788 2.91e-38 128.0 2DP49@1|root,330FY@2|Bacteria,1VH78@1239|Firmicutes,3VU9R@526524|Erysipelotrichia 526524|Erysipelotrichia - - - - - - - - - - - - - - - KKPNOBBG_01971 1235800.C819_01441 8.43e-82 244.0 COG1881@1|root,COG1881@2|Bacteria,1VK8D@1239|Firmicutes,25DHH@186801|Clostridia,27J8P@186928|unclassified Lachnospiraceae 186801|Clostridia S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP KKPNOBBG_01972 1123304.AQYA01000027_gene1858 2.75e-96 288.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B KKPNOBBG_01973 1321774.HMPREF9108_00027 7.4e-23 92.8 2C4JB@1|root,30BI1@2|Bacteria,37A9A@32066|Fusobacteria 32066|Fusobacteria S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_01974 742740.HMPREF9474_02156 2.25e-101 297.0 COG2135@1|root,COG2135@2|Bacteria,1TRRV@1239|Firmicutes,24GD7@186801|Clostridia,21Z7J@1506553|Lachnoclostridium 186801|Clostridia S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP KKPNOBBG_01975 742740.HMPREF9474_02155 3.42e-243 674.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,21XPT@1506553|Lachnoclostridium 186801|Clostridia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH KKPNOBBG_01976 469596.HMPREF9488_01482 2.81e-26 97.8 2E5DV@1|root,3305T@2|Bacteria,1VEZ4@1239|Firmicutes,3VU9U@526524|Erysipelotrichia 526524|Erysipelotrichia - - - - - - - - - - - - - - - KKPNOBBG_01977 1235798.C817_01767 2.9e-64 199.0 2BQ07@1|root,32IUB@2|Bacteria,1V9A8@1239|Firmicutes,24KKD@186801|Clostridia 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C KKPNOBBG_01978 767817.Desgi_0222 1.04e-18 82.0 29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF3795) - - - - - - - - - - - - DUF3795 KKPNOBBG_01979 553973.CLOHYLEM_05170 1.87e-117 335.0 COG1670@1|root,COG1670@2|Bacteria,1VBV7@1239|Firmicutes,24NM7@186801|Clostridia,2229B@1506553|Lachnoclostridium 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_8 KKPNOBBG_01980 1469948.JPNB01000001_gene741 1.99e-176 496.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPIM@1239|Firmicutes,2480Y@186801|Clostridia,36IHT@31979|Clostridiaceae 186801|Clostridia K GyrI-like small molecule binding domain - - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 KKPNOBBG_01981 457421.CBFG_00231 2.69e-137 388.0 COG3665@1|root,COG3665@2|Bacteria,1V1VR@1239|Firmicutes,25DA7@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 KKPNOBBG_01982 1232453.BAIF02000041_gene3411 8.67e-43 140.0 COG1396@1|root,COG1396@2|Bacteria,1VDA0@1239|Firmicutes,24PY4@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_01983 1232453.BAIF02000016_gene3147 1.02e-42 140.0 COG1396@1|root,COG1396@2|Bacteria,1VCDA@1239|Firmicutes,24NHY@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_01984 1232453.BAIF02000016_gene3148 1.79e-62 194.0 2B903@1|root,322AR@2|Bacteria,1V7MZ@1239|Firmicutes,24JPH@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01985 1235798.C817_02170 9.92e-172 484.0 COG0849@1|root,COG0849@2|Bacteria,1UIFR@1239|Firmicutes,25EM6@186801|Clostridia,27XE8@189330|Dorea 186801|Clostridia D StbA protein - - - ko:K18640 - - - - ko00000,ko04812 - - - StbA KKPNOBBG_01986 1232453.BAIF02000017_gene3151 1.39e-36 125.0 2EA91@1|root,334DG@2|Bacteria,1VER1@1239|Firmicutes,24SBA@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01987 1232453.BAIF02000017_gene3152 7.56e-59 188.0 2DKWP@1|root,30MQ3@2|Bacteria,1V68I@1239|Firmicutes,24K3B@186801|Clostridia,26CNA@186813|unclassified Clostridiales 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_01988 1232453.BAIF02000042_gene3401 2.14e-49 165.0 28HR1@1|root,2Z7YI@2|Bacteria,1TRNR@1239|Firmicutes,2486X@186801|Clostridia,268I0@186813|unclassified Clostridiales 186801|Clostridia S Putative amidoligase enzyme - - - - - - - - - - - - Amidoligase_2 KKPNOBBG_01989 1232453.BAIF02000017_gene3155 3.75e-138 395.0 28HR1@1|root,2Z7YI@2|Bacteria,1TRNR@1239|Firmicutes,2486X@186801|Clostridia,268I0@186813|unclassified Clostridiales 186801|Clostridia S Putative amidoligase enzyme - - - - - - - - - - - - Amidoligase_2 KKPNOBBG_01990 1232453.BAIF02000126_gene127 3.13e-92 272.0 COG2105@1|root,COG2105@2|Bacteria,1VDAD@1239|Firmicutes,24HW1@186801|Clostridia,26914@186813|unclassified Clostridiales 186801|Clostridia S AIG2-like family - - - - - - - - - - - - GGACT KKPNOBBG_01992 1232453.BAIF02000126_gene126 2.54e-88 294.0 COG4932@1|root,COG4932@2|Bacteria,1TRG6@1239|Firmicutes,2492K@186801|Clostridia,26CHD@186813|unclassified Clostridiales 186801|Clostridia M Psort location Cellwall, score - - - - - - - - - - - - - KKPNOBBG_01993 411462.DORLON_01315 2.35e-198 556.0 COG0582@1|root,COG0582@2|Bacteria,1TXU3@1239|Firmicutes,24C0Y@186801|Clostridia,27UZR@189330|Dorea 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Phage_integrase KKPNOBBG_01994 1235792.C808_03208 3.86e-240 681.0 COG0582@1|root,COG0582@2|Bacteria,1TQQ1@1239|Firmicutes,24BI9@186801|Clostridia,27JWM@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase KKPNOBBG_01995 1235792.C808_03207 1.54e-215 612.0 COG0582@1|root,COG0582@2|Bacteria,1U0FV@1239|Firmicutes,24B44@186801|Clostridia,27KC7@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Phage_integrase KKPNOBBG_01996 411462.DORLON_01312 2.29e-38 132.0 2D1NJ@1|root,32TB2@2|Bacteria,1VA9P@1239|Firmicutes,24NS8@186801|Clostridia,27XC5@189330|Dorea 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01997 1226325.HMPREF1548_02420 4.09e-230 636.0 28KCT@1|root,2Z9ZM@2|Bacteria,1V4TK@1239|Firmicutes,24FYS@186801|Clostridia,36NY1@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_01998 1226325.HMPREF1548_02419 0.0 912.0 COG0476@1|root,COG0476@2|Bacteria,1V6DI@1239|Firmicutes,24JAM@186801|Clostridia,36NQZ@31979|Clostridiaceae 186801|Clostridia H ThiF family - - - - - - - - - - - - Prok-E2_B,ThiF KKPNOBBG_01999 1226325.HMPREF1548_02418 8.57e-90 266.0 COG1310@1|root,COG1310@2|Bacteria,1VF3A@1239|Firmicutes,24S2E@186801|Clostridia,36Q08@31979|Clostridiaceae 186801|Clostridia S Prokaryotic homologs of the JAB domain - - - - - - - - - - - - Prok-JAB KKPNOBBG_02000 1226325.HMPREF1548_02417 7.22e-153 434.0 2CC5W@1|root,32VTX@2|Bacteria,1VBIS@1239|Firmicutes,24JKP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02001 1539298.JO41_07780 1.27e-41 140.0 2C4JB@1|root,30BI1@2|Bacteria,2J7UW@203691|Spirochaetes 203691|Spirochaetes - - - - - - - - - - - - - - - KKPNOBBG_02002 767817.Desgi_0222 7.98e-17 77.0 29X3G@1|root,30IS5@2|Bacteria,1W5BE@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF3795) - - - - - - - - - - - - DUF3795 KKPNOBBG_02003 471875.RUMLAC_01572 2.16e-167 469.0 COG1484@1|root,COG1484@2|Bacteria,1TQBX@1239|Firmicutes,249T2@186801|Clostridia,3WIMB@541000|Ruminococcaceae 186801|Clostridia L DNA replication protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP KKPNOBBG_02004 411462.DORLON_01409 0.0 926.0 COG4584@1|root,COG4584@2|Bacteria,1TNY9@1239|Firmicutes,24B59@186801|Clostridia,27WIW@189330|Dorea 186801|Clostridia L Integrase core domain - - - - - - - - - - - - rve KKPNOBBG_02005 33035.JPJF01000009_gene1506 0.0 1216.0 COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,3XYP5@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Radical_SAM KKPNOBBG_02006 33035.JPJF01000009_gene1507 2.85e-146 414.0 COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,3XZQP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF2344 KKPNOBBG_02007 33035.JPJF01000009_gene1508 3.52e-246 681.0 COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia,3XYXV@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1,TRAM KKPNOBBG_02008 33035.JPJF01000009_gene1509 1.22e-117 336.0 COG1051@1|root,COG1051@2|Bacteria,1V3IM@1239|Firmicutes,24HEA@186801|Clostridia,3Y016@572511|Blautia 186801|Clostridia F NUDIX domain mutX - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX KKPNOBBG_02009 33035.JPJF01000009_gene1510 1.46e-219 608.0 COG1266@1|root,COG1266@2|Bacteria,1VJMM@1239|Firmicutes,25AQE@186801|Clostridia,3Y0B9@572511|Blautia 186801|Clostridia S CAAX amino terminal protease family protein - - - ko:K07052 - - - - ko00000 - - - Abi KKPNOBBG_02010 33035.JPJF01000009_gene1511 9.42e-63 192.0 COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,3Y060@572511|Blautia 186801|Clostridia J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p KKPNOBBG_02011 33035.JPJF01000009_gene1512 2.39e-67 204.0 COG2868@1|root,COG2868@2|Bacteria,1VCNG@1239|Firmicutes,25N63@186801|Clostridia,3Y0KN@572511|Blautia 186801|Clostridia J Cysteine protease Prp - - - ko:K07584 - - - - ko00000 - - - Peptidase_Prp KKPNOBBG_02012 33035.JPJF01000009_gene1513 6.25e-60 184.0 COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,3Y06C@572511|Blautia 186801|Clostridia J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 KKPNOBBG_02013 33035.JPJF01000009_gene1514 4.41e-306 835.0 COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,3XYJQ@572511|Blautia 186801|Clostridia S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - DUF1967,GTP1_OBG,MMR_HSR1 KKPNOBBG_02014 33035.JPJF01000009_gene1515 2.38e-56 176.0 COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,3Y0BI@572511|Blautia 186801|Clostridia J RNA-binding protein containing KH domain, possibly ribosomal protein yhbY - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY KKPNOBBG_02015 33035.JPJF01000009_gene1516 5.5e-154 432.0 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,3XZHC@572511|Blautia 186801|Clostridia H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like KKPNOBBG_02016 33035.JPJF01000009_gene1517 4.38e-133 378.0 COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,24HN2@186801|Clostridia,3XYUN@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like,HD KKPNOBBG_02017 33035.JPJF01000009_gene1518 4e-76 227.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,3Y07Y@572511|Blautia 186801|Clostridia J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS KKPNOBBG_02018 33035.JPJF01000009_gene1519 4.17e-132 375.0 COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3XYNM@572511|Blautia 186801|Clostridia L Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 KKPNOBBG_02019 33035.JPJF01000009_gene1520 2e-58 182.0 COG1388@1|root,COG1388@2|Bacteria,1VK5T@1239|Firmicutes,25DQN@186801|Clostridia,3Y0UF@572511|Blautia 186801|Clostridia M Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery - - - - - - - - - - - - LysM KKPNOBBG_02020 1280694.AUJQ01000001_gene2144 5.23e-60 187.0 COG0454@1|root,COG0456@2|Bacteria,1V8KY@1239|Firmicutes,24J02@186801|Clostridia 186801|Clostridia K acetyltransferase - - - - - - - - - - - - DUF3795 KKPNOBBG_02021 33035.JPJF01000009_gene1522 3.91e-246 677.0 COG1609@1|root,COG1609@2|Bacteria,1UYY5@1239|Firmicutes,24C8C@186801|Clostridia,3XZ1C@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_02022 33035.JPJF01000009_gene1523 8.66e-157 442.0 COG1349@1|root,COG1349@2|Bacteria,1V27B@1239|Firmicutes,24DD2@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - DeoRC,HTH_DeoR KKPNOBBG_02023 33035.JPJF01000009_gene1524 1.5e-99 294.0 COG4639@1|root,COG4639@2|Bacteria,1TU32@1239|Firmicutes,25NIJ@186801|Clostridia,3Y25J@572511|Blautia 186801|Clostridia S AAA domain - - - - - - - - - - - - - KKPNOBBG_02024 33035.JPJF01000009_gene1525 9.61e-305 833.0 COG0371@1|root,COG0371@2|Bacteria,1TR6W@1239|Firmicutes,25AGX@186801|Clostridia,3XZXG@572511|Blautia 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH_2 KKPNOBBG_02025 33035.JPJF01000009_gene1526 1.23e-197 549.0 COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,24AQ8@186801|Clostridia,3XZNJ@572511|Blautia 186801|Clostridia G COG COG2017 Galactose mutarotase and related enzymes lacX - - - - - - - - - - - Aldose_epim KKPNOBBG_02026 33035.JPJF01000009_gene1527 5.22e-150 424.0 COG0745@1|root,COG0745@2|Bacteria,1TQ0D@1239|Firmicutes,248WX@186801|Clostridia,3XZRP@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02027 33035.JPJF01000009_gene1528 7.55e-245 678.0 COG0642@1|root,COG2205@2|Bacteria,1TRZX@1239|Firmicutes,249AI@186801|Clostridia,3XYP2@572511|Blautia 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_02028 33035.JPJF01000009_gene1529 1.04e-191 534.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3XZ40@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02029 33035.JPJF01000009_gene1530 1.37e-250 693.0 28IVE@1|root,2Z8TU@2|Bacteria,1UYXD@1239|Firmicutes,24CW0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - ABC2_membrane_3 KKPNOBBG_02030 33035.JPJF01000009_gene1531 8.19e-110 319.0 2DK34@1|root,308A7@2|Bacteria,1U33E@1239|Firmicutes,259PD@186801|Clostridia,3Y21K@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02031 33035.JPJF01000009_gene1532 2.08e-160 451.0 COG1476@1|root,COG1476@2|Bacteria,1UIFY@1239|Firmicutes,24BCF@186801|Clostridia 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26,HTH_3 KKPNOBBG_02032 33035.JPJF01000009_gene1533 1.41e-78 237.0 COG0745@1|root,COG0745@2|Bacteria,1VGWK@1239|Firmicutes,24SIJ@186801|Clostridia 186801|Clostridia KT Sporulation initiation factor Spo0A C terminal - - - - - - - - - - - - Spo0A_C KKPNOBBG_02033 33035.JPJF01000009_gene1534 6.43e-160 449.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3XZCU@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - ko:K18349 ko01502,ko02020,map01502,map02020 M00652,M00657 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_02034 33035.JPJF01000009_gene1535 8.02e-214 597.0 COG5002@1|root,COG5002@2|Bacteria,1TPB6@1239|Firmicutes,24AV5@186801|Clostridia,3XZYQ@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K18350 ko01502,ko02020,map01502,map02020 M00652,M00657 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA KKPNOBBG_02035 33035.JPJF01000009_gene1536 9.29e-167 472.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,24AQE@186801|Clostridia,3XZNY@572511|Blautia 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 KKPNOBBG_02036 33035.JPJF01000009_gene1539 0.0 878.0 COG0488@1|root,COG0488@2|Bacteria,1TNYS@1239|Firmicutes,248D6@186801|Clostridia,3XZ6M@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.49 - - - ko:K19350 ko02010,map02010 - - - ko00000,ko00001,ko01504,ko02000 3.A.1.121 - - ABC_tran KKPNOBBG_02037 33035.JPJF01000009_gene1540 2.66e-189 530.0 COG3173@1|root,COG3173@2|Bacteria,1U6NE@1239|Firmicutes,2489R@186801|Clostridia 186801|Clostridia S Phosphotransferase enzyme family - - - - - - - - - - - - APH KKPNOBBG_02038 33035.JPJF01000009_gene1542 0.0 1424.0 COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,3XYNU@572511|Blautia 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran,Transglut_core KKPNOBBG_02039 33035.JPJF01000009_gene1543 1.02e-126 363.0 2E33N@1|root,32Y3S@2|Bacteria,1VFAP@1239|Firmicutes,24R1K@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC2_membrane_5 KKPNOBBG_02040 33035.JPJF01000009_gene1544 2.17e-186 520.0 COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,3XZ9A@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - - - - - - - - - - ABC_tran KKPNOBBG_02041 33035.JPJF01000009_gene1545 1.03e-75 227.0 COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,3Y0I1@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_02042 33035.JPJF01000009_gene1546 1.03e-175 493.0 COG0583@1|root,COG0583@2|Bacteria,1TNZR@1239|Firmicutes,25C6R@186801|Clostridia 186801|Clostridia K LysR substrate binding domain protein - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02043 33035.JPJF01000009_gene1547 5.43e-111 321.0 COG2059@1|root,COG2059@2|Bacteria,1V22C@1239|Firmicutes,24H9X@186801|Clostridia,3Y2BY@572511|Blautia 186801|Clostridia P Chromate transporter - - - - - - - - - - - - Chromate_transp KKPNOBBG_02044 33035.JPJF01000009_gene1548 5.69e-112 323.0 COG2059@1|root,COG2059@2|Bacteria,1V5EX@1239|Firmicutes,24HY8@186801|Clostridia,3Y2BZ@572511|Blautia 186801|Clostridia P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp KKPNOBBG_02045 33035.JPJF01000009_gene1549 0.0 923.0 COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,3XZRA@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07137 - - - - ko00000 - - - FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4 KKPNOBBG_02046 33035.JPJF01000009_gene1550 1.2e-137 391.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,3Y06R@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02047 33035.JPJF01000009_gene1551 2.16e-206 575.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,3Y000@572511|Blautia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_02048 33035.JPJF01000009_gene1552 8.52e-168 470.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia 186801|Clostridia V ABC-type antimicrobial peptide transport system, ATPase component - - - - - - - - - - - - ABC_tran KKPNOBBG_02049 33035.JPJF01000009_gene1553 0.0 1103.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3Y0AT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_02050 33035.JPJF01000009_gene1554 1.13e-250 689.0 COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,3XZGH@572511|Blautia 186801|Clostridia C COG COG0371 Glycerol dehydrogenase and related enzymes dhaD - 1.1.1.6 ko:K00005 ko00561,ko00640,ko01100,map00561,map00640,map01100 - R01034,R10715,R10717 RC00029,RC00117,RC00670 ko00000,ko00001,ko01000 - - - Fe-ADH KKPNOBBG_02051 33035.JPJF01000009_gene1555 4.37e-253 698.0 COG2207@1|root,COG2207@2|Bacteria,1TQD7@1239|Firmicutes,24DSW@186801|Clostridia,3Y1J2@572511|Blautia 1239|Firmicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC KKPNOBBG_02052 33035.JPJF01000009_gene1556 9.14e-283 772.0 COG2730@1|root,COG2730@2|Bacteria,1TS9M@1239|Firmicutes,24DA9@186801|Clostridia,3XZ6Z@572511|Blautia 186801|Clostridia G Cellulase (glycosyl hydrolase family 5) - - - - - - - - - - - - Cellulase KKPNOBBG_02053 33035.JPJF01000009_gene1557 0.0 868.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,3XZZ6@572511|Blautia 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_02054 33035.JPJF01000009_gene1558 0.0 1054.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,3Y14Y@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 43 - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_43 KKPNOBBG_02055 33035.JPJF01000009_gene1559 1e-275 758.0 COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia 186801|Clostridia T PFAM metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD KKPNOBBG_02056 411902.CLOBOL_00564 6.41e-07 47.8 29HZ9@1|root,304WA@2|Bacteria,1UECC@1239|Firmicutes,25J86@186801|Clostridia,221JT@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02057 457421.CBFG_00150 5.29e-194 541.0 COG2378@1|root,COG2378@2|Bacteria,1TT23@1239|Firmicutes,248A8@186801|Clostridia 186801|Clostridia K HTH domain - - - - - - - - - - - - HTH_11,WYL KKPNOBBG_02058 457421.CBFG_00149 3.28e-84 252.0 COG1335@1|root,COG1335@2|Bacteria,1TQTE@1239|Firmicutes,24BQ4@186801|Clostridia 186801|Clostridia Q Isochorismatase family - - - - - - - - - - - - Isochorismatase KKPNOBBG_02059 588581.Cpap_1206 1.05e-96 283.0 COG1476@1|root,COG1476@2|Bacteria,1TP7T@1239|Firmicutes,24G95@186801|Clostridia,3WSQD@541000|Ruminococcaceae 186801|Clostridia K Helix-turn-helix - - - ko:K07726 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_02060 33035.JPJF01000009_gene1561 4.85e-75 225.0 COG3682@1|root,COG3682@2|Bacteria,1V7EY@1239|Firmicutes,24N11@186801|Clostridia,3Y08G@572511|Blautia 186801|Clostridia K beta-lactamase (penicillinase) repressor blaI - - ko:K02171 ko01501,map01501 M00627 - - ko00000,ko00001,ko00002,ko01504,ko03000 - - - Penicillinase_R KKPNOBBG_02061 33035.JPJF01000009_gene1562 2.32e-305 847.0 COG2602@1|root,COG4219@1|root,COG2602@2|Bacteria,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,249NV@186801|Clostridia,3XYWY@572511|Blautia 186801|Clostridia KTV Psort location CytoplasmicMembrane, score blaR - - ko:K02172 ko01501,map01501 M00627 - - ko00000,ko00001,ko00002,ko01002,ko01504 - - - Peptidase_M56,Transpeptidase KKPNOBBG_02062 33035.JPJF01000009_gene1564 1.09e-243 674.0 COG0477@1|root,COG2814@2|Bacteria,1TRZB@1239|Firmicutes,24YGV@186801|Clostridia 186801|Clostridia EGP PFAM Major Facilitator Superfamily - - - ko:K08217 - - - - br01600,ko00000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 - - MFS_1,MFS_3 KKPNOBBG_02063 33035.JPJF01000009_gene1566 2.39e-203 563.0 COG2207@1|root,COG2207@2|Bacteria,1TPNZ@1239|Firmicutes,24A6R@186801|Clostridia,3Y15Z@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_02064 33035.JPJF01000009_gene1567 4.11e-201 559.0 COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,249RU@186801|Clostridia 186801|Clostridia EG metabolite transporter - - - - - - - - - - - - EamA KKPNOBBG_02065 33035.JPJF01000009_gene1568 8.03e-87 256.0 COG4954@1|root,COG4954@2|Bacteria,1V9Z7@1239|Firmicutes,24HGY@186801|Clostridia,3Y1U7@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF2000) - - - - - - - - - - - - DUF2000 KKPNOBBG_02066 33035.JPJF01000048_gene676 1.53e-33 118.0 2EJVN@1|root,3053J@2|Bacteria,1TUXT@1239|Firmicutes,25PYC@186801|Clostridia,3Y21F@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02067 33035.JPJF01000048_gene685 1.66e-248 683.0 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,25C3N@186801|Clostridia,3XYHX@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 xerS - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase KKPNOBBG_02068 1392491.JIAE01000001_gene1236 1.35e-102 305.0 COG0535@1|root,COG0535@2|Bacteria,1V98T@1239|Firmicutes,24KUI@186801|Clostridia,3WRXR@541000|Ruminococcaceae 186801|Clostridia S Radical SAM superfamily - - - - - - - - - - - - Fer4_12,Radical_SAM KKPNOBBG_02069 33035.JPJF01000048_gene686 5.1e-252 697.0 COG0038@1|root,COG0038@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,3Y07Q@572511|Blautia 186801|Clostridia P Voltage gated chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC KKPNOBBG_02070 411468.CLOSCI_03423 1.15e-138 394.0 COG0745@1|root,COG0745@2|Bacteria,1TT12@1239|Firmicutes,24AB1@186801|Clostridia,21XX7@1506553|Lachnoclostridium 186801|Clostridia K COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02071 332101.JIBU02000013_gene1357 1.71e-174 493.0 COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia,36G6U@31979|Clostridiaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_02072 1499684.CCNP01000018_gene693 6.93e-120 346.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae 186801|Clostridia V ABC transporter lolD - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02074 1499684.CCNP01000018_gene691 2.8e-147 430.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,24AWU@186801|Clostridia,36FYR@31979|Clostridiaceae 186801|Clostridia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_02075 1499684.CCNP01000018_gene690 2.9e-57 205.0 COG0845@1|root,COG0845@2|Bacteria,1V96V@1239|Firmicutes 1239|Firmicutes M Efflux transporter rnd family, mfp subunit - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_02076 350688.Clos_0788 3.94e-90 283.0 COG0642@1|root,COG2205@2|Bacteria,1UHQC@1239|Firmicutes,2496X@186801|Clostridia,36HCI@31979|Clostridiaceae 186801|Clostridia T Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_02077 350688.Clos_0787 2.87e-92 277.0 COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia,36HPB@31979|Clostridiaceae 186801|Clostridia T PFAM response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02078 1226325.HMPREF1548_04795 2.76e-76 234.0 COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,24FY0@186801|Clostridia,36ICE@31979|Clostridiaceae 186801|Clostridia P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp KKPNOBBG_02079 658086.HMPREF0994_00402 4.69e-192 539.0 COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,25B10@186801|Clostridia,27JTT@186928|unclassified Lachnospiraceae 186801|Clostridia C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_02080 1232453.BAIF02000066_gene2127 5.13e-268 738.0 COG0642@1|root,COG2205@2|Bacteria,1UYAJ@1239|Firmicutes,24CIQ@186801|Clostridia,26AF2@186813|unclassified Clostridiales 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c_5,HisKA KKPNOBBG_02081 1235792.C808_01188 6.56e-143 406.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,27KV6@186928|unclassified Lachnospiraceae 186801|Clostridia K Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_02082 1235792.C808_01197 3.16e-09 58.9 29A4Y@1|root,2ZX60@2|Bacteria,1W3FV@1239|Firmicutes,255KK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02083 665956.HMPREF1032_00732 4.3e-67 204.0 COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24N2T@186801|Clostridia,3WQ13@541000|Ruminococcaceae 186801|Clostridia K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR KKPNOBBG_02084 97139.C824_03715 5.33e-122 349.0 COG1853@1|root,COG1853@2|Bacteria,1UYJS@1239|Firmicutes,24DWF@186801|Clostridia,36VGS@31979|Clostridiaceae 186801|Clostridia S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct KKPNOBBG_02086 658086.HMPREF0994_05081 4.77e-48 162.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_02087 658086.HMPREF0994_02807 1.32e-190 533.0 COG4905@1|root,COG4905@2|Bacteria,1V2HX@1239|Firmicutes,24GGX@186801|Clostridia,27P77@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative ABC-transporter type IV - - - - - - - - - - - - ABC_trans_CmpB KKPNOBBG_02088 1235797.C816_01207 6.98e-114 343.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,2N7B0@216572|Oscillospiraceae 186801|Clostridia C Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17,Fer4_9 KKPNOBBG_02089 180332.JTGN01000004_gene2704 9.76e-84 253.0 COG0110@1|root,COG0110@2|Bacteria,1TSQQ@1239|Firmicutes,24B8G@186801|Clostridia 186801|Clostridia S Bacterial transferase hexapeptide repeat protein - - - - - - - - - - - - Hexapep,Hexapep_2 KKPNOBBG_02090 553973.CLOHYLEM_07113 4.38e-27 100.0 2DIP2@1|root,303S9@2|Bacteria,1TUIG@1239|Firmicutes,2584Q@186801|Clostridia,223F3@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02091 877414.ATWA01000004_gene556 3.04e-107 320.0 COG5434@1|root,COG5434@2|Bacteria,1TQXN@1239|Firmicutes,24APX@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - DUF3737 KKPNOBBG_02092 658086.HMPREF0994_05673 1.1e-171 484.0 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,27I9B@186928|unclassified Lachnospiraceae 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02093 1151292.QEW_2527 1.18e-162 458.0 COG0500@1|root,COG2226@2|Bacteria,1V0UT@1239|Firmicutes,24B8S@186801|Clostridia,25TN8@186804|Peptostreptococcaceae 186801|Clostridia Q Tellurite resistance protein TehB - - - - - - - - - - - - Acetyltransf_3,Methyltransf_11,Methyltransf_25 KKPNOBBG_02094 1151292.QEW_2528 4.47e-104 304.0 COG1309@1|root,COG1309@2|Bacteria,1UH5U@1239|Firmicutes,249A2@186801|Clostridia,25U2U@186804|Peptostreptococcaceae 186801|Clostridia K WHG domain - - - - - - - - - - - - TetR_N,WHG KKPNOBBG_02095 553973.CLOHYLEM_07364 1.66e-151 442.0 COG0642@1|root,COG2205@2|Bacteria,1UHQC@1239|Firmicutes,2496X@186801|Clostridia,220BC@1506553|Lachnoclostridium 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_02096 553973.CLOHYLEM_07365 1.74e-135 386.0 COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia,22036@1506553|Lachnoclostridium 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02097 553973.CLOHYLEM_07366 0.0 1046.0 COG3590@1|root,COG3590@2|Bacteria,1TQTA@1239|Firmicutes,2482M@186801|Clostridia,21Z4C@1506553|Lachnoclostridium 186801|Clostridia O Peptidase family M13 pepO1 - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N KKPNOBBG_02098 553973.CLOHYLEM_07478 0.0 883.0 COG2199@1|root,COG2199@2|Bacteria,1UKSD@1239|Firmicutes,25KNF@186801|Clostridia,2226M@1506553|Lachnoclostridium 186801|Clostridia T Cache domain - - - - - - - - - - - - GGDEF,HAMP,dCache_1 KKPNOBBG_02099 588581.Cpap_3934 2.04e-41 149.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24DB9@186801|Clostridia,3WHMG@541000|Ruminococcaceae 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_02101 610130.Closa_1737 2.79e-98 322.0 COG5002@1|root,COG5002@2|Bacteria,1UINY@1239|Firmicutes,25EPM@186801|Clostridia,2202V@1506553|Lachnoclostridium 186801|Clostridia T Signal transduction histidine kinase regulating citrate malate metabolism - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_02102 1504823.CCMM01000007_gene678 1.31e-26 124.0 COG3525@1|root,COG5263@1|root,COG3525@2|Bacteria,COG5263@2|Bacteria 2|Bacteria S dextransucrase activity lacZ - 3.2.1.23,3.2.1.52 ko:K01190,ko:K12373 ko00052,ko00511,ko00513,ko00520,ko00531,ko00600,ko00603,ko00604,ko01100,ko04142,map00052,map00511,map00513,map00520,map00531,map00600,map00603,map00604,map01100,map04142 M00079 R00022,R01105,R01678,R03355,R04783,R06004,R06114,R11316 RC00049,RC00452 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CW_binding_1,F5_F8_type_C,Glug,Glyco_hydro_20,Peptidase_C39_2,SLH,YSIRK_signal KKPNOBBG_02103 553973.CLOHYLEM_05325 7.46e-150 444.0 COG2186@1|root,COG2186@2|Bacteria,1V12R@1239|Firmicutes,24QFG@186801|Clostridia,2206U@1506553|Lachnoclostridium 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_02104 33035.JPJF01000048_gene699 4.65e-134 381.0 28HI8@1|root,2Z9QV@2|Bacteria,1UZZ2@1239|Firmicutes,24IH2@186801|Clostridia,3XZY4@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4317) - - - - - - - - - - - - DUF4317 KKPNOBBG_02105 33035.JPJF01000048_gene701 1.83e-70 212.0 COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24JJB@186801|Clostridia,3Y0QK@572511|Blautia 186801|Clostridia K HxlR-like helix-turn-helix ydeP - - - - - - - - - - - HxlR KKPNOBBG_02106 33035.JPJF01000048_gene702 3.51e-88 259.0 COG5015@1|root,COG5015@2|Bacteria,1V4P5@1239|Firmicutes,25D0I@186801|Clostridia,3Y007@572511|Blautia 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase like - - - - - - - - - - - - Putative_PNPOx KKPNOBBG_02107 33035.JPJF01000048_gene704 0.0 2403.0 COG1201@1|root,COG1201@2|Bacteria,1UHYQ@1239|Firmicutes,25E79@186801|Clostridia 186801|Clostridia L DEAD DEAH box helicase - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C KKPNOBBG_02108 33035.JPJF01000048_gene705 2.62e-188 525.0 COG0789@1|root,COG0789@2|Bacteria,1UZFF@1239|Firmicutes,24EUZ@186801|Clostridia 186801|Clostridia K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 KKPNOBBG_02109 33035.JPJF01000048_gene706 2.05e-271 749.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,24BRV@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_02110 1121333.JMLH01000053_gene601 1.94e-90 268.0 2CAVT@1|root,304CC@2|Bacteria,1V4J6@1239|Firmicutes,3VR3M@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2798 KKPNOBBG_02111 556261.HMPREF0240_00054 7.19e-78 238.0 COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,24N24@186801|Clostridia 186801|Clostridia J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C KKPNOBBG_02112 33035.JPJF01000048_gene707 0.0 1221.0 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1TQ8P@1239|Firmicutes,25E38@186801|Clostridia,3XZ2P@572511|Blautia 186801|Clostridia MV COG COG0577 ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_02113 33035.JPJF01000048_gene708 3.01e-145 410.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XZQT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02114 33035.JPJF01000048_gene709 2.16e-203 571.0 COG0642@1|root,COG2205@2|Bacteria,1TR7T@1239|Firmicutes,24CJ8@186801|Clostridia,3Y0BH@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_02115 33035.JPJF01000048_gene710 7.49e-138 392.0 COG0745@1|root,COG0745@2|Bacteria,1TT12@1239|Firmicutes,24AB1@186801|Clostridia,3Y2AY@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02116 33035.JPJF01000048_gene711 2.44e-185 517.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,3Y1G2@572511|Blautia 186801|Clostridia K Bacterial transcription activator, effector binding domain - - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 KKPNOBBG_02117 33035.JPJF01000048_gene712 5.37e-165 474.0 2E1BR@1|root,32WRK@2|Bacteria,1V7RQ@1239|Firmicutes,24RD9@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02118 33035.JPJF01000048_gene713 1.37e-229 650.0 COG0845@1|root,COG0845@2|Bacteria,1V156@1239|Firmicutes,24E26@186801|Clostridia,3Y06F@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_02119 33035.JPJF01000048_gene714 1.5e-173 487.0 COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,2488S@186801|Clostridia,3XYW1@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_02120 33035.JPJF01000048_gene715 3.6e-182 509.0 COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,3Y0K9@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02121 33035.JPJF01000048_gene716 0.0 1138.0 COG1653@1|root,COG1653@2|Bacteria,1V04I@1239|Firmicutes,247SU@186801|Clostridia,3XZJE@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_02122 33035.JPJF01000048_gene717 1.24e-135 386.0 COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,25B20@186801|Clostridia 186801|Clostridia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02123 33035.JPJF01000048_gene718 1.59e-215 605.0 COG5002@1|root,COG5002@2|Bacteria,1URKI@1239|Firmicutes,248WK@186801|Clostridia,3XZE3@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_02125 33035.JPJF01000048_gene719 2.42e-100 322.0 COG5263@1|root,COG5263@2|Bacteria,1VH35@1239|Firmicutes,25KD3@186801|Clostridia,3Y04J@572511|Blautia 186801|Clostridia D Peptidase family M23 - - - - - - - - - - - - CW_binding_1,Peptidase_M23 KKPNOBBG_02126 33035.JPJF01000050_gene826 1.58e-95 279.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,3Y036@572511|Blautia 186801|Clostridia J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase KKPNOBBG_02127 33035.JPJF01000050_gene827 6.74e-239 664.0 COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,3XZ5I@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - AI-2E_transport KKPNOBBG_02128 33035.JPJF01000050_gene828 7.16e-174 484.0 COG0037@1|root,COG0037@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia,3XZK0@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 ttcA2 - - - - - - - - - - - ATP_bind_3 KKPNOBBG_02129 33035.JPJF01000050_gene829 1.11e-144 408.0 COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249Z9@186801|Clostridia,3XYXM@572511|Blautia 186801|Clostridia F COG NOG14451 non supervised orthologous group - - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 KKPNOBBG_02130 33035.JPJF01000050_gene830 3.55e-211 584.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,3XYRA@572511|Blautia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 KKPNOBBG_02131 33035.JPJF01000050_gene831 1.14e-108 314.0 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,3Y0CB@572511|Blautia 186801|Clostridia M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 KKPNOBBG_02132 33035.JPJF01000050_gene832 4.29e-254 697.0 COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,3XYS7@572511|Blautia 186801|Clostridia E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase KKPNOBBG_02133 33035.JPJF01000050_gene833 8.83e-163 457.0 COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,3XZX9@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - S4 KKPNOBBG_02134 33035.JPJF01000050_gene834 3.94e-95 282.0 COG1799@1|root,COG1799@2|Bacteria,1V5NF@1239|Firmicutes,25CNH@186801|Clostridia,3Y2EY@572511|Blautia 186801|Clostridia D Pfam:DUF552 sepF - - ko:K09772 - - - - ko00000,ko03036 - - - SepF KKPNOBBG_02135 33035.JPJF01000050_gene835 4.58e-151 426.0 COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,3XYQJ@572511|Blautia 186801|Clostridia S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis ylmE - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N KKPNOBBG_02136 33035.JPJF01000050_gene836 9.07e-303 831.0 2DBI9@1|root,2Z9F5@2|Bacteria,1UI10@1239|Firmicutes,25E9Z@186801|Clostridia,3XZB6@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02137 33035.JPJF01000050_gene837 6.73e-42 137.0 COG2155@1|root,COG2155@2|Bacteria,1TU48@1239|Firmicutes,259I6@186801|Clostridia,3Y0R3@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF378) - - - ko:K09779 - - - - ko00000 - - - DUF378 KKPNOBBG_02138 33035.JPJF01000050_gene838 6.09e-87 256.0 COG0433@1|root,COG0433@2|Bacteria,1VF8X@1239|Firmicutes,24N9T@186801|Clostridia,3Y046@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02139 33035.JPJF01000050_gene839 4.66e-235 648.0 COG1686@1|root,COG1686@2|Bacteria,1TU06@1239|Firmicutes,25B23@186801|Clostridia,3XYXF@572511|Blautia 186801|Clostridia M COG COG1686 D-alanyl-D-alanine carboxypeptidase - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S11 KKPNOBBG_02140 537007.BLAHAN_04753 6.55e-84 248.0 COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,3Y0B8@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS KKPNOBBG_02141 33035.JPJF01000050_gene841 2.37e-237 656.0 COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,3XZJI@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score 10.00 rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE KKPNOBBG_02142 537007.BLAHAN_04751 1.89e-32 114.0 COG0851@1|root,COG0851@2|Bacteria,1UD8J@1239|Firmicutes,25HWB@186801|Clostridia,3Y0VC@572511|Blautia 186801|Clostridia D Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell minE - - ko:K03608 - - - - ko00000,ko03036,ko04812 - - - MinE KKPNOBBG_02143 33035.JPJF01000050_gene843 3.8e-179 499.0 COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia,3XZ45@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 minD - - ko:K03609 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA KKPNOBBG_02144 33035.JPJF01000050_gene844 0.0 1774.0 COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,3XYNZ@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase KKPNOBBG_02145 33035.JPJF01000050_gene845 6.85e-115 330.0 COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24GF4@186801|Clostridia,3Y080@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score 9.99 mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD KKPNOBBG_02146 33035.JPJF01000050_gene846 7.27e-192 535.0 COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,3XYIE@572511|Blautia 186801|Clostridia M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC KKPNOBBG_02147 33035.JPJF01000050_gene847 2.13e-230 635.0 COG1077@1|root,COG1077@2|Bacteria,1TPVU@1239|Firmicutes,248CM@186801|Clostridia,3XZ2N@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl KKPNOBBG_02148 33035.JPJF01000050_gene848 5.22e-162 454.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,3XZVG@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 radC - - ko:K03630 - - - - ko00000 - - - RadC KKPNOBBG_02149 33035.JPJF01000050_gene849 0.0 874.0 COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,3XZI2@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07137 - - - - ko00000 - - - HI0933_like,NAD_binding_8,Pyr_redox_2 KKPNOBBG_02150 33035.JPJF01000050_gene850 2.74e-266 731.0 COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,3XZAP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07007 - - - - ko00000 - - - HI0933_like KKPNOBBG_02151 33035.JPJF01000050_gene851 1.27e-306 836.0 COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3XZKZ@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 ynbB - - - - - - - - - - - Met_gamma_lyase KKPNOBBG_02152 33035.JPJF01000050_gene852 5.53e-216 598.0 COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,3XYZN@572511|Blautia 186801|Clostridia H Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT KKPNOBBG_02153 33035.JPJF01000050_gene853 0.0 1033.0 COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3XYSA@572511|Blautia 186801|Clostridia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C KKPNOBBG_02154 33035.JPJF01000050_gene854 0.0 1710.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,3XZGZ@572511|Blautia 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V KKPNOBBG_02155 33035.JPJF01000050_gene855 0.0 915.0 COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,3XZB4@572511|Blautia 186801|Clostridia H Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 KKPNOBBG_02156 33035.JPJF01000050_gene856 6.9e-41 135.0 COG4224@1|root,COG4224@2|Bacteria,1TUAX@1239|Firmicutes,24QS9@186801|Clostridia,3Y0QD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 ynzC - - - - - - - - - - - DUF896 KKPNOBBG_02157 33035.JPJF01000050_gene857 1.42e-183 512.0 COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,3XYIF@572511|Blautia 186801|Clostridia H Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA KKPNOBBG_02158 33035.JPJF01000050_gene858 1.86e-103 300.0 2EJV3@1|root,33DJR@2|Bacteria,1VKNR@1239|Firmicutes,25Q1A@186801|Clostridia,3Y0TC@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02159 33035.JPJF01000050_gene859 2.96e-269 740.0 COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,3Y0I0@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF3048) C-terminal domain yerB - - - - - - - - - - - DUF3048,DUF3048_C KKPNOBBG_02160 33035.JPJF01000050_gene860 8.51e-105 303.0 COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,3Y06H@572511|Blautia 186801|Clostridia S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - 3.5.4.5 ko:K01489,ko:K07042 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000,ko03009 - - - UPF0054 KKPNOBBG_02161 556261.HMPREF0240_02891 2.79e-150 432.0 COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,36UI2@31979|Clostridiaceae 186801|Clostridia T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH KKPNOBBG_02162 1235790.C805_02633 7.29e-153 444.0 2BZD2@1|root,2Z88S@2|Bacteria,1UZZH@1239|Firmicutes,24F57@186801|Clostridia,25Y25@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02163 1235790.C805_02634 2.02e-117 341.0 COG1131@1|root,COG1131@2|Bacteria,1TRG3@1239|Firmicutes,248K1@186801|Clostridia,25Y1J@186806|Eubacteriaceae 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02164 1235790.C805_02635 1.41e-20 82.8 2ENRX@1|root,336BY@2|Bacteria,1VGQE@1239|Firmicutes,24U1U@186801|Clostridia,25YW2@186806|Eubacteriaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02165 397288.C806_04287 2.71e-108 333.0 COG0642@1|root,COG0642@2|Bacteria 2|Bacteria T Histidine kinase regB - 2.7.13.3 ko:K07717,ko:K15011 ko02020,map02020 M00518,M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HATPase_c_5,HisKA KKPNOBBG_02166 478749.BRYFOR_08356 4.16e-113 331.0 COG3279@1|root,COG3279@2|Bacteria,1UYV2@1239|Firmicutes,24F5U@186801|Clostridia 186801|Clostridia KT Psort location Cytoplasmic, score - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_02167 411902.CLOBOL_06215 7.9e-143 419.0 COG1408@1|root,COG1408@2|Bacteria,1TS43@1239|Firmicutes,248XA@186801|Clostridia,220KZ@1506553|Lachnoclostridium 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07098 - - - - ko00000 - - - Metallophos KKPNOBBG_02168 658086.HMPREF0994_01651 3.96e-144 409.0 COG0778@1|root,COG0778@2|Bacteria,1V0I6@1239|Firmicutes,24ASS@186801|Clostridia 186801|Clostridia C Putative TM nitroreductase - - - - - - - - - - - - TM1586_NiRdase KKPNOBBG_02169 658086.HMPREF0994_01650 1.23e-91 271.0 COG0778@1|root,COG0778@2|Bacteria,1VIF2@1239|Firmicutes,24GUE@186801|Clostridia 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase KKPNOBBG_02170 658086.HMPREF0994_01649 4.6e-102 299.0 COG1309@1|root,COG1309@2|Bacteria,1VH8G@1239|Firmicutes,24SA7@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_02171 33035.JPJF01000012_gene2353 2.54e-75 226.0 COG4747@1|root,COG4747@2|Bacteria,1V8ZY@1239|Firmicutes,24NAM@186801|Clostridia,3Y0M9@572511|Blautia 186801|Clostridia S ACT domain protein - - - - - - - - - - - - - KKPNOBBG_02172 33035.JPJF01000012_gene2354 1.09e-203 570.0 COG0561@1|root,COG0561@2|Bacteria,1TR3N@1239|Firmicutes,24ACD@186801|Clostridia,3XYIC@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yqfD - - ko:K06438 - - - - ko00000 - - - YqfD KKPNOBBG_02173 33035.JPJF01000079_gene9 1.21e-58 181.0 2DVZX@1|root,33XWD@2|Bacteria,1U4E1@1239|Firmicutes,24VHN@186801|Clostridia,3Y0V7@572511|Blautia 186801|Clostridia S COG NOG13846 non supervised orthologous group - - - - - - - - - - - - YabP KKPNOBBG_02174 33035.JPJF01000079_gene10 6.1e-126 359.0 COG5423@1|root,COG5423@2|Bacteria,1V5IN@1239|Firmicutes,24JW6@186801|Clostridia,3XZUH@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF2284 KKPNOBBG_02175 33035.JPJF01000079_gene12 7.22e-285 819.0 COG1511@1|root,COG1511@2|Bacteria,1TQ15@1239|Firmicutes,24A8K@186801|Clostridia,3XYKM@572511|Blautia 186801|Clostridia S Psort location Cellwall, score - - - ko:K01421 - - - - ko00000 - - - - KKPNOBBG_02176 33035.JPJF01000079_gene13 0.0 1271.0 COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,3XYKA@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07003 - - - - ko00000 - - - MMPL KKPNOBBG_02177 33035.JPJF01000079_gene14 9.72e-139 392.0 COG1309@1|root,COG1309@2|Bacteria,1V3ZS@1239|Firmicutes,24H9U@186801|Clostridia,3XZV5@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TetR_N KKPNOBBG_02178 33035.JPJF01000079_gene15 1.04e-170 478.0 COG0454@1|root,COG0456@2|Bacteria,1V8NW@1239|Firmicutes,25B2F@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_02179 33035.JPJF01000079_gene16 1.38e-158 445.0 COG2176@1|root,COG2176@2|Bacteria,1V3E4@1239|Firmicutes,249X5@186801|Clostridia,3XZPP@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T KKPNOBBG_02180 33035.JPJF01000079_gene17 1.14e-96 282.0 2E639@1|root,330SD@2|Bacteria,1VN8W@1239|Firmicutes,24WUI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02181 33035.JPJF01000079_gene18 1.14e-103 302.0 28M7B@1|root,2ZAKT@2|Bacteria,1TQPQ@1239|Firmicutes,24B5V@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - MmcB-like KKPNOBBG_02182 33035.JPJF01000079_gene19 1.07e-191 537.0 28IH1@1|root,2Z8IC@2|Bacteria,1TSE5@1239|Firmicutes,249UI@186801|Clostridia,3Y15Y@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF4003) - - - - - - - - - - - - DUF4003 KKPNOBBG_02183 33035.JPJF01000079_gene20 6.33e-187 522.0 COG1578@1|root,COG1578@2|Bacteria,1UURD@1239|Firmicutes,2492C@186801|Clostridia,3Y04B@572511|Blautia 186801|Clostridia S Protein of unknown function DUF89 - - - ko:K09116 - - - - ko00000 - - - DUF89 KKPNOBBG_02184 33035.JPJF01000016_gene3845 0.0 1105.0 COG4219@1|root,COG4219@2|Bacteria,1TP3Z@1239|Firmicutes,24FVB@186801|Clostridia,3Y017@572511|Blautia 186801|Clostridia KT BlaR1 peptidase M56 - - - ko:K02172 ko01501,map01501 M00627 - - ko00000,ko00001,ko00002,ko01002,ko01504 - - - DUF4097,DUF4825,DUF4829,Peptidase_M56 KKPNOBBG_02185 33035.JPJF01000016_gene3846 3.67e-80 238.0 COG3682@1|root,COG3682@2|Bacteria,1TUS9@1239|Firmicutes,25MRG@186801|Clostridia,3Y1RD@572511|Blautia 186801|Clostridia K Penicillinase repressor - - - - - - - - - - - - Penicillinase_R KKPNOBBG_02186 411460.RUMTOR_02695 5.14e-255 702.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3XYZE@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 adh - - - - - - - - - - - Fe-ADH KKPNOBBG_02187 33035.JPJF01000016_gene3848 5.8e-134 381.0 COG2102@1|root,COG2102@2|Bacteria,1UAKZ@1239|Firmicutes,24C6P@186801|Clostridia 186801|Clostridia S Diphthamide synthase - - - - - - - - - - - - Diphthami_syn_2 KKPNOBBG_02189 33035.JPJF01000016_gene3849 6e-40 134.0 COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,3Y0N1@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 KKPNOBBG_02190 33035.JPJF01000016_gene3850 3.94e-58 185.0 28Z82@1|root,2ZM05@2|Bacteria,1W1JP@1239|Firmicutes,256QK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02191 1280673.AUJJ01000025_gene1275 9.39e-101 303.0 COG0454@1|root,COG0456@2|Bacteria,1UXXB@1239|Firmicutes,248N5@186801|Clostridia,4BWJG@830|Butyrivibrio 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_9 KKPNOBBG_02192 357809.Cphy_0973 7.3e-178 503.0 COG1506@1|root,COG1506@2|Bacteria,1UISH@1239|Firmicutes,25EZ7@186801|Clostridia 186801|Clostridia E PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 KKPNOBBG_02193 411470.RUMGNA_02509 1.33e-106 310.0 28P9U@1|root,2ZC37@2|Bacteria,1V32C@1239|Firmicutes,24FS7@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Acetyltransf_3 KKPNOBBG_02195 33035.JPJF01000016_gene3851 2.74e-99 290.0 28PZ1@1|root,2ZCII@2|Bacteria,1V2GX@1239|Firmicutes,24IE1@186801|Clostridia,3Y0MC@572511|Blautia 186801|Clostridia S Domain of unknown function, E. rectale Gene description (DUF3877) - - - - - - - - - - - - DUF3877 KKPNOBBG_02196 1007096.BAGW01000018_gene765 5.61e-41 138.0 2CTED@1|root,32ST9@2|Bacteria,1VD31@1239|Firmicutes,24Q04@186801|Clostridia,2N8GI@216572|Oscillospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02197 33035.JPJF01000016_gene3852 2.81e-197 550.0 COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,3XZIM@572511|Blautia 186801|Clostridia H Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS KKPNOBBG_02198 33035.JPJF01000016_gene3853 6.72e-43 141.0 28QBC@1|root,2ZCTY@2|Bacteria,1W2AX@1239|Firmicutes,24UH4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02199 33035.JPJF01000016_gene3855 9.57e-144 407.0 COG1011@1|root,COG1011@2|Bacteria,1TWM7@1239|Firmicutes,24HKY@186801|Clostridia,3Y0IN@572511|Blautia 186801|Clostridia S HAD-hyrolase-like - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_02200 1232453.BAIF02000110_gene767 2.22e-118 353.0 2DMYR@1|root,32UEZ@2|Bacteria,1VCPN@1239|Firmicutes,24MHC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02201 33035.JPJF01000016_gene3859 4.28e-102 296.0 COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,3XZU3@572511|Blautia 186801|Clostridia H Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase KKPNOBBG_02202 33035.JPJF01000016_gene3860 6.87e-150 423.0 COG4912@1|root,COG4912@2|Bacteria,1TQII@1239|Firmicutes,248N8@186801|Clostridia,3XZY3@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DNA_alkylation KKPNOBBG_02203 33035.JPJF01000016_gene3861 0.0 914.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3XZ00@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 KKPNOBBG_02204 33035.JPJF01000016_gene3862 6.07e-222 610.0 COG0543@1|root,COG0543@2|Bacteria,1TP6D@1239|Firmicutes,247YB@186801|Clostridia,3XZM3@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 pyrK_1 - 1.18.1.2,1.19.1.1 ko:K00528,ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146,R10159 RC00065 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 KKPNOBBG_02205 33035.JPJF01000016_gene3863 8.53e-198 556.0 COG0457@1|root,COG0457@2|Bacteria,1UZDE@1239|Firmicutes,24HQ4@186801|Clostridia,3Y29Z@572511|Blautia 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - CHB_HEX_C_1,TPR_19 KKPNOBBG_02206 33035.JPJF01000016_gene3864 0.0 1487.0 COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,3XYXU@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma KKPNOBBG_02207 33035.JPJF01000016_gene3865 6.81e-194 540.0 COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,3XZWE@572511|Blautia 186801|Clostridia V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA KKPNOBBG_02208 33035.JPJF01000016_gene3866 8.88e-153 431.0 COG0740@1|root,COG0740@2|Bacteria,1TPX2@1239|Firmicutes,249QX@186801|Clostridia,3XZDI@572511|Blautia 186801|Clostridia OU Psort location Cytoplasmic, score 8.87 tepA - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease KKPNOBBG_02210 33035.JPJF01000016_gene3868 1.28e-167 469.0 COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,3XYGX@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 yebC - - - - - - - - - - - Transcrip_reg KKPNOBBG_02211 33035.JPJF01000016_gene3869 3.87e-296 811.0 COG1253@1|root,COG1253@2|Bacteria,1U77R@1239|Firmicutes,25CBE@186801|Clostridia,3XZ2E@572511|Blautia 186801|Clostridia S Transporter associated domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 KKPNOBBG_02212 33035.JPJF01000016_gene3872 1.44e-233 642.0 COG0407@1|root,COG0407@2|Bacteria,1TNZU@1239|Firmicutes,24A05@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_02213 33035.JPJF01000016_gene3873 1.17e-75 226.0 COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,24JE1@186801|Clostridia,3Y03Z@572511|Blautia 186801|Clostridia L Toxic component of a toxin-antitoxin (TA) module ndoA - - ko:K07171 - - - - ko00000,ko01000,ko02048 - - - PemK_toxin KKPNOBBG_02214 33035.JPJF01000016_gene3874 6.24e-256 704.0 COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,3XYKK@572511|Blautia 186801|Clostridia M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N KKPNOBBG_02215 33035.JPJF01000016_gene3875 0.0 899.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,3XZEG@572511|Blautia 186801|Clostridia H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - ACPS,Carb_kinase,YjeF_N KKPNOBBG_02216 33035.JPJF01000016_gene3876 3.57e-151 425.0 COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,3XZKT@572511|Blautia 186801|Clostridia K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex - - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N KKPNOBBG_02217 33035.JPJF01000016_gene3877 0.0 1111.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3XYWT@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.49 - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn KKPNOBBG_02218 33035.JPJF01000016_gene3878 1.5e-166 468.0 COG1277@1|root,COG1277@2|Bacteria,1V2P1@1239|Firmicutes,24BRH@186801|Clostridia,3Y0EK@572511|Blautia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 KKPNOBBG_02219 33035.JPJF01000016_gene3879 6.51e-194 540.0 COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,24941@186801|Clostridia,3XZG6@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,SRP54 KKPNOBBG_02220 33035.JPJF01000016_gene3881 3.72e-282 772.0 COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,3XZ3V@572511|Blautia 186801|Clostridia C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh KKPNOBBG_02221 33035.JPJF01000016_gene3882 8.38e-154 433.0 COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24E6I@186801|Clostridia,3XZX2@572511|Blautia 186801|Clostridia K FCD - - - - - - - - - - - - FCD,GntR KKPNOBBG_02222 33035.JPJF01000016_gene3883 0.0 935.0 COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,3XZMI@572511|Blautia 186801|Clostridia E COG COG0119 Isopropylmalate homocitrate citramalate synthases - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0036440,GO:0046912,GO:0050450 - - - - - - - - - iHN637.CLJU_RS03250 HMGL-like KKPNOBBG_02223 33035.JPJF01000016_gene3884 2.23e-196 545.0 COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,3XYHC@572511|Blautia 186801|Clostridia O Psort location Extracellular, score aprX - - ko:K17734 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S8 KKPNOBBG_02224 33035.JPJF01000016_gene3885 0.0 1078.0 COG1404@1|root,COG1404@2|Bacteria,1TQE0@1239|Firmicutes,25B1A@186801|Clostridia,3XYTR@572511|Blautia 186801|Clostridia O COG COG1404 Subtilisin-like serine proteases - - - - - - - - - - - - Peptidase_S8 KKPNOBBG_02225 33035.JPJF01000016_gene3886 3.71e-19 81.3 2DSHC@1|root,33G4Q@2|Bacteria,1VMRV@1239|Firmicutes,25AFM@186801|Clostridia,3Y0T4@572511|Blautia 186801|Clostridia S Psort location Extracellular, score 8.82 - - - - - - - - - - - - - KKPNOBBG_02227 33035.JPJF01000016_gene3888 2.04e-68 207.0 2BB22@1|root,324I6@2|Bacteria,1UQT3@1239|Firmicutes,258J6@186801|Clostridia,3Y0Q8@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02228 33035.JPJF01000016_gene3890 4.09e-48 162.0 2EMJQ@1|root,32KAG@2|Bacteria,1URUU@1239|Firmicutes,259SC@186801|Clostridia,3Y0NU@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02229 33035.JPJF01000016_gene3891 3.91e-287 786.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3Y099@572511|Blautia 186801|Clostridia S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth KKPNOBBG_02230 33035.JPJF01000016_gene3892 8.59e-115 330.0 COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,3XZV4@572511|Blautia 186801|Clostridia I Psort location CytoplasmicMembrane, score pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf KKPNOBBG_02231 33035.JPJF01000016_gene3893 9.08e-314 855.0 COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,3XYI9@572511|Blautia 186801|Clostridia H Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 KKPNOBBG_02232 33035.JPJF01000016_gene3894 2.89e-44 144.0 COG1758@1|root,COG1758@2|Bacteria,1VF65@1239|Firmicutes,257WP@186801|Clostridia,3Y0N6@572511|Blautia 186801|Clostridia K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 KKPNOBBG_02233 33035.JPJF01000016_gene3895 4.14e-139 394.0 COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,3XYVA@572511|Blautia 186801|Clostridia F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin KKPNOBBG_02234 33035.JPJF01000016_gene3896 8.61e-54 169.0 COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia,3Y0BZ@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF370) NPD7_560 - - ko:K09777 - - - - ko00000 - - - DUF370 KKPNOBBG_02235 33035.JPJF01000016_gene3897 3.6e-192 538.0 COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,3XZFM@572511|Blautia 186801|Clostridia S Psort location yicC - - - - - - - - - - - DUF1732,YicC_N KKPNOBBG_02236 33035.JPJF01000016_gene3898 0.0 1079.0 COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,3XZD2@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 FbpA - - - - - - - - - - - DUF814,FbpA KKPNOBBG_02237 33035.JPJF01000016_gene3899 0.0 930.0 COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,3XZ3F@572511|Blautia 186801|Clostridia S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 KKPNOBBG_02238 33035.JPJF01000016_gene3900 0.0 996.0 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3XZDF@572511|Blautia 186801|Clostridia O Heat shock 70 kDa protein - - - - - - - - - - - - HSP70 KKPNOBBG_02239 33035.JPJF01000016_gene3901 0.0 1694.0 COG0457@1|root,COG0457@2|Bacteria,1UKYH@1239|Firmicutes,24B57@186801|Clostridia 186801|Clostridia O tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_12,TPR_16,TPR_19,TPR_2,TPR_8 KKPNOBBG_02240 33035.JPJF01000016_gene3902 0.0 881.0 COG2199@1|root,COG2199@2|Bacteria,1V0N3@1239|Firmicutes,24FMU@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF KKPNOBBG_02241 33035.JPJF01000016_gene3904 1.57e-91 269.0 2CGYA@1|root,345S7@2|Bacteria,1UI0A@1239|Firmicutes,24S83@186801|Clostridia 186801|Clostridia S CheW-like domain - - - - - - - - - - - - CheW KKPNOBBG_02242 33035.JPJF01000016_gene3905 0.0 1191.0 COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia 186801|Clostridia T Signal transducing histidine kinase homodimeric - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 KKPNOBBG_02243 33035.JPJF01000016_gene3906 5.19e-223 615.0 COG2199@1|root,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,249J7@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - GGDEF,Response_reg KKPNOBBG_02244 33035.JPJF01000016_gene3907 3.33e-90 266.0 COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia 186801|Clostridia NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD KKPNOBBG_02245 33035.JPJF01000016_gene3908 1.59e-108 316.0 COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia 186801|Clostridia NT Chemotaxis protein CheC, inhibitor of MCP methylation cheC - - ko:K03410 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheC KKPNOBBG_02246 33035.JPJF01000016_gene3909 1.92e-283 788.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal KKPNOBBG_02247 33035.JPJF01000016_gene3910 1.47e-74 224.0 COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia 186801|Clostridia T response regulator receiver cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg KKPNOBBG_02248 33035.JPJF01000016_gene3911 4.24e-166 468.0 COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia 186801|Clostridia NT PFAM MCP methyltransferase, CheR-type cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N KKPNOBBG_02249 33035.JPJF01000016_gene3912 6e-62 191.0 2DCSZ@1|root,2ZF86@2|Bacteria,1W408@1239|Firmicutes,24T8Z@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02250 33035.JPJF01000016_gene3913 3.87e-67 206.0 29VD7@1|root,30GTW@2|Bacteria,1UGMV@1239|Firmicutes,24V4J@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02251 33035.JPJF01000016_gene3914 0.0 1642.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,3XZ20@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 KKPNOBBG_02252 33035.JPJF01000016_gene3915 0.0 998.0 2BW99@1|root,2Z7PD@2|Bacteria,1TQFA@1239|Firmicutes,249NB@186801|Clostridia,3XYY5@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02253 33035.JPJF01000016_gene3916 0.0 1356.0 COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,3XZ5X@572511|Blautia 186801|Clostridia J translation elongation factor G fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 KKPNOBBG_02254 33035.JPJF01000016_gene3917 1.7e-261 716.0 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,3XZI7@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDH KKPNOBBG_02255 33035.JPJF01000016_gene3918 9.67e-263 724.0 COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,3XZCI@572511|Blautia 186801|Clostridia E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase KKPNOBBG_02256 33035.JPJF01000016_gene3919 1.8e-129 368.0 COG1309@1|root,COG1309@2|Bacteria,1UYIP@1239|Firmicutes,249K5@186801|Clostridia,3XZUQ@572511|Blautia 186801|Clostridia K Transcriptional regulator C-terminal region - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_02257 33035.JPJF01000016_gene3920 0.0 1184.0 COG4716@1|root,COG4716@2|Bacteria,1TQZ6@1239|Firmicutes,248TZ@186801|Clostridia,3XZ82@572511|Blautia 186801|Clostridia S MCRA family - - 4.2.1.53 ko:K10254 - - - - ko00000,ko01000 - - - MCRA KKPNOBBG_02258 1292035.H476_1804 3.3e-120 380.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,25SK2@186804|Peptostreptococcaceae 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_02259 1301100.HG529315_gene453 6.54e-133 382.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,36DTD@31979|Clostridiaceae 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02260 1292035.H476_1806 8.88e-89 276.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,25UNX@186804|Peptostreptococcaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c KKPNOBBG_02261 1301100.HG529315_gene451 9.56e-93 278.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,36EMS@31979|Clostridiaceae 186801|Clostridia T response regulator - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02262 33035.JPJF01000016_gene3927 0.0 1794.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg,SnoaL_3 KKPNOBBG_02263 33035.JPJF01000016_gene3928 1.27e-174 490.0 COG1595@1|root,COG1595@2|Bacteria,1TSCX@1239|Firmicutes,24CVD@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_02264 33035.JPJF01000016_gene3929 4.34e-127 365.0 COG5587@1|root,COG5587@2|Bacteria,1TX75@1239|Firmicutes,24CP8@186801|Clostridia 186801|Clostridia S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 KKPNOBBG_02265 33035.JPJF01000016_gene3930 0.0 1785.0 COG0642@1|root,COG0784@1|root,COG2199@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg,dCache_1 KKPNOBBG_02266 33035.JPJF01000016_gene3931 6.41e-239 664.0 COG1653@1|root,COG1653@2|Bacteria,1TR6Q@1239|Firmicutes,24CVU@186801|Clostridia 186801|Clostridia G ABC transporter periplasmic binding protein ycjN - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_02267 33035.JPJF01000016_gene3934 0.0 1059.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3Y1FR@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF,PAS_3 KKPNOBBG_02268 33035.JPJF01000016_gene3935 0.0 892.0 COG0492@1|root,COG3634@1|root,COG0492@2|Bacteria,COG3634@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3Y126@572511|Blautia 186801|Clostridia C Thioredoxin domain trxB1 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Thioredoxin_3 KKPNOBBG_02269 33035.JPJF01000016_gene3936 2.37e-129 367.0 COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,3Y1GN@572511|Blautia 186801|Clostridia O C-terminal domain of 1-Cys peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA KKPNOBBG_02270 33035.JPJF01000016_gene3937 6.21e-96 283.0 2996G@1|root,2ZW9T@2|Bacteria,1VG83@1239|Firmicutes,24TDX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02271 33035.JPJF01000016_gene3939 1.29e-278 763.0 COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,3XYHM@572511|Blautia 186801|Clostridia C anaerobic nitric oxide reductase flavorubredoxin norV - - - - - - - - - - - Flavodoxin_1,Flavodoxin_5,Lactamase_B,Lactamase_B_2 KKPNOBBG_02272 33035.JPJF01000016_gene3942 0.0 1367.0 COG0577@1|root,COG0577@2|Bacteria,1TV1M@1239|Firmicutes,24E2X@186801|Clostridia,3Y0XJ@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - - - - - - - - - - FtsX KKPNOBBG_02273 33035.JPJF01000016_gene3943 4.74e-139 395.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XZQT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02274 33035.JPJF01000016_gene3944 1.88e-178 502.0 COG0642@1|root,COG2205@2|Bacteria,1TR7T@1239|Firmicutes,24CJ8@186801|Clostridia,3XZXT@572511|Blautia 186801|Clostridia T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_02275 33035.JPJF01000016_gene3945 8.75e-142 403.0 COG0745@1|root,COG0745@2|Bacteria,1TSNV@1239|Firmicutes,2493A@186801|Clostridia,3Y04C@572511|Blautia 186801|Clostridia KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02276 33035.JPJF01000016_gene3946 0.0 1040.0 COG2199@1|root,COG2199@2|Bacteria,COG3706@2|Bacteria,1U78Z@1239|Firmicutes,24NZ8@186801|Clostridia,3Y14E@572511|Blautia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 KKPNOBBG_02277 33035.JPJF01000016_gene3947 0.0 1313.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg KKPNOBBG_02278 435591.BDI_1710 9.69e-58 180.0 COG5561@1|root,COG5561@2|Bacteria,4PEPI@976|Bacteroidetes,2FY87@200643|Bacteroidia 976|Bacteroidetes S CGGC - - - - - - - - - - - - CGGC KKPNOBBG_02279 1379858.N508_00614 2.24e-13 72.8 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N KKPNOBBG_02280 553973.CLOHYLEM_07555 2.89e-244 676.0 COG1277@1|root,COG1277@2|Bacteria,1UYSH@1239|Firmicutes 1239|Firmicutes S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - ABC2_membrane_2 KKPNOBBG_02281 553973.CLOHYLEM_07556 3.11e-183 513.0 COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,24941@186801|Clostridia,21YFG@1506553|Lachnoclostridium 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02282 553973.CLOHYLEM_07557 2.7e-204 566.0 COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,24941@186801|Clostridia,21YFG@1506553|Lachnoclostridium 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02283 553973.CLOHYLEM_07558 1.87e-103 303.0 COG1309@1|root,COG1309@2|Bacteria,1VH8G@1239|Firmicutes,24SA7@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - TetR_C_8,TetR_N KKPNOBBG_02284 553973.CLOHYLEM_06206 6.98e-144 436.0 COG3087@1|root,COG3087@2|Bacteria 2|Bacteria D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - 3.1.1.3 ko:K01046,ko:K14194 ko00561,ko01100,ko05150,map00561,map01100,map05150 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - NYN,SPOR KKPNOBBG_02285 658086.HMPREF0994_05656 1.01e-220 623.0 COG2188@1|root,COG2188@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K02027,ko:K03710 - M00207 - - ko00000,ko00002,ko02000,ko03000 3.A.1.1 - - GntR KKPNOBBG_02286 553973.CLOHYLEM_07174 0.0 1262.0 COG2199@1|root,COG5001@1|root,COG2199@2|Bacteria,COG5001@2|Bacteria,1V0FH@1239|Firmicutes,24A9M@186801|Clostridia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF KKPNOBBG_02287 553973.CLOHYLEM_07175 1.9e-291 806.0 COG2199@1|root,COG2199@2|Bacteria,1U3KI@1239|Firmicutes,24CEI@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 KKPNOBBG_02288 33035.JPJF01000016_gene3969 1.81e-240 662.0 COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3XZ7B@572511|Blautia 186801|Clostridia H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth KKPNOBBG_02289 33035.JPJF01000016_gene3970 1.86e-146 412.0 COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia,3Y00C@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - His_Phos_1 KKPNOBBG_02290 33035.JPJF01000016_gene3971 0.0 1548.0 COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3XYMD@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind KKPNOBBG_02291 33035.JPJF01000016_gene3972 5.4e-229 632.0 COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,3XYKQ@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 10.00 pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d KKPNOBBG_02292 33035.JPJF01000016_gene3973 1.34e-200 560.0 COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia,3XZ63@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score yihY - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB KKPNOBBG_02293 33035.JPJF01000016_gene3974 2.05e-277 767.0 COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia,3XYJD@572511|Blautia 186801|Clostridia D Stage II sporulation protein - - - ko:K06381 - - - - ko00000 - - - SpoIID KKPNOBBG_02294 33035.JPJF01000016_gene3975 0.0 917.0 COG4262@1|root,COG4262@2|Bacteria,1UYRF@1239|Firmicutes,24AHS@186801|Clostridia 186801|Clostridia S Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth KKPNOBBG_02295 33035.JPJF01000016_gene3976 5.37e-248 681.0 COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,3XZFA@572511|Blautia 186801|Clostridia G Converts alpha-aldose to the beta-anomer mro - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim KKPNOBBG_02296 33035.JPJF01000016_gene3977 1.59e-168 472.0 COG2206@1|root,COG2206@2|Bacteria,1V23X@1239|Firmicutes,24GQ5@186801|Clostridia,3XZI6@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HD KKPNOBBG_02297 33035.JPJF01000016_gene3978 0.0 1125.0 COG1866@1|root,COG1866@2|Bacteria,1TPXB@1239|Firmicutes,24BKF@186801|Clostridia 186801|Clostridia H Phosphoenolpyruvate carboxykinase (ATP) - - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP KKPNOBBG_02298 33035.JPJF01000016_gene3979 0.0 919.0 COG0498@1|root,COG0498@2|Bacteria,1TPR0@1239|Firmicutes,248YY@186801|Clostridia,3XZ3J@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS16355 PALP,Thr_synth_N KKPNOBBG_02299 33035.JPJF01000016_gene3980 4.62e-171 479.0 COG3773@1|root,COG3773@2|Bacteria,1VAUD@1239|Firmicutes,25B1B@186801|Clostridia,3XZWR@572511|Blautia 186801|Clostridia M Cell Wall Hydrolase - - 3.5.1.28 ko:K01449 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Hydrolase_2,LysM KKPNOBBG_02301 33035.JPJF01000016_gene3983 0.0 1052.0 COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,3XYGQ@572511|Blautia 186801|Clostridia H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,HTH_18,LeuA_dimer KKPNOBBG_02302 33035.JPJF01000016_gene3985 2.04e-91 267.0 COG5015@1|root,COG5015@2|Bacteria,1V43Y@1239|Firmicutes,24HQB@186801|Clostridia 186801|Clostridia K PFAM pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx KKPNOBBG_02305 573413.Spirs_3380 7.81e-84 264.0 COG0407@1|root,COG0407@2|Bacteria,2JAKX@203691|Spirochaetes 203691|Spirochaetes H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D KKPNOBBG_02306 1042156.CXIVA_21400 6.84e-86 279.0 COG2508@1|root,COG2508@2|Bacteria,1VDTX@1239|Firmicutes,24NVQ@186801|Clostridia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_02307 33035.JPJF01000016_gene3990 1.06e-80 242.0 COG3476@1|root,COG3476@2|Bacteria,1V896@1239|Firmicutes,24MTF@186801|Clostridia,3Y0FN@572511|Blautia 186801|Clostridia T TspO/MBR family - - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR KKPNOBBG_02308 411468.CLOSCI_03516 2.27e-103 304.0 COG4461@1|root,COG4461@2|Bacteria,1VDVF@1239|Firmicutes,24N0M@186801|Clostridia,21ZZE@1506553|Lachnoclostridium 186801|Clostridia S Domain of unknown function (DUF4163) - - - - - - - - - - - - DUF3298,DUF4163 KKPNOBBG_02309 33035.JPJF01000016_gene3993 6.8e-84 250.0 COG1051@1|root,COG1051@2|Bacteria,1VH0H@1239|Firmicutes,24Q66@186801|Clostridia 186801|Clostridia F NUDIX domain - - - - - - - - - - - - NUDIX KKPNOBBG_02310 33035.JPJF01000016_gene3994 1.49e-113 325.0 COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3XZW2@572511|Blautia 186801|Clostridia E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01704,ko:K20453 ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R10170 RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C KKPNOBBG_02311 33035.JPJF01000016_gene3995 1.85e-303 827.0 COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3XYP1@572511|Blautia 186801|Clostridia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35,4.2.1.85 ko:K01703,ko:K20452 ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230 M00432,M00535 R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04465 Aconitase KKPNOBBG_02312 33035.JPJF01000016_gene3996 3.09e-212 586.0 COG0583@1|root,COG0583@2|Bacteria,1TR84@1239|Firmicutes,24BU7@186801|Clostridia,3XZQ2@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02313 33035.JPJF01000016_gene3997 3.6e-242 665.0 COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,3XYWE@572511|Blautia 186801|Clostridia H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN KKPNOBBG_02314 33035.JPJF01000016_gene3998 1.02e-108 314.0 COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,3Y022@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10025 ACT,ACT_5,ALS_ss_C KKPNOBBG_02315 33035.JPJF01000016_gene3999 1.15e-243 674.0 28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,248TG@186801|Clostridia,3XZ6I@572511|Blautia 186801|Clostridia S DHHW protein - - - - - - - - - - - - DHHW KKPNOBBG_02316 33035.JPJF01000016_gene4000 7.63e-294 806.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,3XYV7@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score 9.99 algI - - ko:K19294 - - - - ko00000 - - - MBOAT KKPNOBBG_02317 33035.JPJF01000016_gene4001 1.52e-85 254.0 2DNPY@1|root,32YIB@2|Bacteria,1VHHM@1239|Firmicutes,24U1K@186801|Clostridia,3Y2D1@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4358) - - - - - - - - - - - - DUF4358 KKPNOBBG_02318 33035.JPJF01000016_gene4002 2e-152 432.0 COG2755@1|root,COG2755@2|Bacteria,1VAV9@1239|Firmicutes,25B1C@186801|Clostridia,3Y0ES@572511|Blautia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_02319 33035.JPJF01000016_gene4003 0.0 953.0 COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,2511Z@186801|Clostridia,3XZHB@572511|Blautia 186801|Clostridia P COG COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - - - - - - - - - - ABC_tran,oligo_HPY KKPNOBBG_02320 33035.JPJF01000016_gene4004 8.94e-79 248.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,3XYJX@572511|Blautia 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_02321 33035.JPJF01000016_gene4004 2.24e-276 763.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,3XYJX@572511|Blautia 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_02322 33035.JPJF01000016_gene4005 9.56e-178 497.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZFZ@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 KKPNOBBG_02323 33035.JPJF01000016_gene4006 4.54e-225 622.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3XZP5@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_02324 33035.JPJF01000016_gene4007 0.0 1277.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ6J@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 enr - 1.3.1.31 ko:K10797 ko00360,ko01120,map00360,map01120 - R02252 RC00669 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_02325 33035.JPJF01000016_gene4008 3.48e-190 530.0 COG0583@1|root,COG0583@2|Bacteria,1U2EY@1239|Firmicutes,24DBM@186801|Clostridia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02326 33035.JPJF01000016_gene4009 1.98e-107 317.0 2DVAH@1|root,32UZ0@2|Bacteria,1VMS9@1239|Firmicutes,24IP4@186801|Clostridia,3Y09C@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF3784 KKPNOBBG_02327 33035.JPJF01000016_gene4010 1.56e-200 563.0 COG1476@1|root,COG1476@2|Bacteria,1TNYC@1239|Firmicutes,248I9@186801|Clostridia,3Y1WY@572511|Blautia 186801|Clostridia K DNA-binding helix-turn-helix protein - - - - - - - - - - - - HTH_3 KKPNOBBG_02328 33035.JPJF01000016_gene4011 4.29e-32 112.0 2E3AZ@1|root,32YAF@2|Bacteria,1VF37@1239|Firmicutes,24R3T@186801|Clostridia 186801|Clostridia S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N KKPNOBBG_02329 33035.JPJF01000016_gene4012 1.65e-192 536.0 COG1131@1|root,COG1131@2|Bacteria,1TQEV@1239|Firmicutes,25B0Q@186801|Clostridia,3Y1FQ@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 KKPNOBBG_02330 33035.JPJF01000016_gene4013 5.92e-148 420.0 COG1277@1|root,COG1277@2|Bacteria,1UYUR@1239|Firmicutes,24HPX@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 KKPNOBBG_02331 33035.JPJF01000016_gene4014 1.19e-87 258.0 COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,3Y0C9@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N KKPNOBBG_02332 33035.JPJF01000016_gene4015 0.0 894.0 COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3XYVU@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N KKPNOBBG_02333 33035.JPJF01000016_gene4016 1.98e-204 566.0 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,3XZ0D@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt KKPNOBBG_02334 33035.JPJF01000016_gene4017 0.0 944.0 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,3XZ7P@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP KKPNOBBG_02335 33035.JPJF01000016_gene4018 3.86e-112 322.0 COG0712@1|root,COG0712@2|Bacteria,1UI0C@1239|Firmicutes,24G5C@186801|Clostridia,3Y09Z@572511|Blautia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP KKPNOBBG_02336 33035.JPJF01000016_gene4019 1.16e-61 194.0 COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,3Y0CM@572511|Blautia 186801|Clostridia C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B KKPNOBBG_02337 33035.JPJF01000016_gene4020 1.32e-35 121.0 COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia,3Y0KZ@572511|Blautia 186801|Clostridia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iHN637.CLJU_RS01165 ATP-synt_C KKPNOBBG_02338 33035.JPJF01000016_gene4021 1.13e-126 361.0 COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,3XZ99@572511|Blautia 186801|Clostridia C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A KKPNOBBG_02339 33035.JPJF01000016_gene4022 2.59e-173 483.0 COG0846@1|root,COG0846@2|Bacteria,1V0UI@1239|Firmicutes,24CGT@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - SIR2 KKPNOBBG_02340 33035.JPJF01000016_gene4023 8.06e-200 554.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3XYM8@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 KKPNOBBG_02341 33035.JPJF01000016_gene4024 1.44e-62 192.0 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3Y0FX@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin KKPNOBBG_02342 33035.JPJF01000016_gene4025 1.87e-146 414.0 COG0664@1|root,COG0664@2|Bacteria,1VBQR@1239|Firmicutes,25CK1@186801|Clostridia,3Y2EU@572511|Blautia 186801|Clostridia T helix_turn_helix, cAMP Regulatory protein - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding KKPNOBBG_02343 33035.JPJF01000016_gene4026 5.67e-140 398.0 COG2755@1|root,COG2755@2|Bacteria,1VB88@1239|Firmicutes,24NGQ@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_02344 33035.JPJF01000016_gene4033 2.62e-106 306.0 COG0394@1|root,COG0394@2|Bacteria,1V6SG@1239|Firmicutes,24MMZ@186801|Clostridia,3Y08X@572511|Blautia 186801|Clostridia T Belongs to the low molecular weight phosphotyrosine protein phosphatase family yfkJ - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc KKPNOBBG_02346 1087448.Eab7_1057 1.15e-13 75.5 28RYR@1|root,333ED@2|Bacteria,1VRTX@1239|Firmicutes,4HTN7@91061|Bacilli 91061|Bacilli - - ynaC - - - - - - - - - - - - KKPNOBBG_02347 655811.HMPREF0078_0631 1.03e-273 754.0 COG4268@1|root,COG4268@2|Bacteria,1TQJI@1239|Firmicutes,24AAV@186801|Clostridia,22IZ5@1570339|Peptoniphilaceae 186801|Clostridia V McrBC 5-methylcytosine restriction system component - - - ko:K19147 - - - - ko00000,ko02048 - - - McrBC KKPNOBBG_02348 655811.HMPREF0078_0630 0.0 1325.0 COG1401@1|root,COG3183@1|root,COG5036@1|root,COG1401@2|Bacteria,COG3183@2|Bacteria,COG5036@2|Bacteria,1TPIP@1239|Firmicutes,249RD@186801|Clostridia,22ISD@1570339|Peptoniphilaceae 186801|Clostridia V ATPase family associated with various cellular activities (AAA) - - - ko:K07452 - - - - ko00000,ko01000,ko02048 - - - AAA_5 KKPNOBBG_02349 1235798.C817_02202 7.03e-214 597.0 COG1403@1|root,COG1403@2|Bacteria,1U2H2@1239|Firmicutes,24QCZ@186801|Clostridia,27X98@189330|Dorea 186801|Clostridia V HNH nucleases - - - - - - - - - - - - HNH_4 KKPNOBBG_02350 626939.HMPREF9443_00342 8.69e-84 253.0 COG2227@1|root,COG2227@2|Bacteria,1V1MT@1239|Firmicutes,4H7JT@909932|Negativicutes 909932|Negativicutes H Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_25 KKPNOBBG_02351 1123075.AUDP01000004_gene792 1.57e-64 198.0 COG1393@1|root,COG1393@2|Bacteria,1V6H8@1239|Firmicutes,24JH6@186801|Clostridia,3WK00@541000|Ruminococcaceae 186801|Clostridia P Belongs to the ArsC family - - - - - - - - - - - - ArsC,Glutaredoxin KKPNOBBG_02352 1235792.C808_02011 1.47e-77 232.0 COG1051@1|root,COG1051@2|Bacteria,1UIGB@1239|Firmicutes,24NCA@186801|Clostridia,27N62@186928|unclassified Lachnospiraceae 186801|Clostridia F NUDIX domain mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX KKPNOBBG_02353 33035.JPJF01000016_gene4051 3.91e-72 217.0 COG1694@1|root,COG1694@2|Bacteria,1VA3E@1239|Firmicutes,24NYY@186801|Clostridia,3Y09V@572511|Blautia 186801|Clostridia S MazG-like family - - - - - - - - - - - - MazG-like KKPNOBBG_02354 33035.JPJF01000016_gene4052 0.0 1013.0 COG1474@1|root,COG3410@1|root,COG1474@2|Bacteria,COG3410@2|Bacteria,1TPQU@1239|Firmicutes,24BAG@186801|Clostridia,3Y0SY@572511|Blautia 186801|Clostridia LO Uncharacterized conserved protein (DUF2075) - - - ko:K09384 - - - - ko00000 - - - DUF2075,GIY-YIG KKPNOBBG_02355 411474.COPEUT_00556 4.78e-25 94.7 COG3655@1|root,COG3655@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - DUF4384,HTH_26,HTH_3 KKPNOBBG_02356 457421.CBFG_03467 5.6e-304 833.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,267TP@186813|unclassified Clostridiales 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_02357 457421.CBFG_03466 8.27e-76 229.0 COG1846@1|root,COG1846@2|Bacteria,1VEFZ@1239|Firmicutes,24MSB@186801|Clostridia,269UD@186813|unclassified Clostridiales 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_02358 457415.HMPREF1006_02523 6.38e-47 170.0 COG5001@1|root,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - - - - - - - - - - - BLUF,GGDEF,PAS_9 KKPNOBBG_02359 1232447.BAHW02000027_gene2055 8.34e-75 228.0 2DBT4@1|root,2ZAVD@2|Bacteria,1V0AF@1239|Firmicutes,24DH6@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Sigma70_r4 KKPNOBBG_02360 1121333.JMLH01000037_gene2021 4.04e-36 126.0 2DE2W@1|root,2ZKAM@2|Bacteria,1V3EH@1239|Firmicutes,3VTHV@526524|Erysipelotrichia 526524|Erysipelotrichia - - - - - - - - - - - - - - - KKPNOBBG_02361 1121333.JMLH01000037_gene2022 3.29e-27 100.0 2D2HR@1|root,32TCU@2|Bacteria,1VA21@1239|Firmicutes 1239|Firmicutes S Sporulation initiation factor Spo0A C terminal - - - - - - - - - - - - Spo0A_C KKPNOBBG_02362 518637.EUBIFOR_00743 6.23e-49 157.0 COG1476@1|root,COG1476@2|Bacteria,1V8YG@1239|Firmicutes,3VS42@526524|Erysipelotrichia 526524|Erysipelotrichia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_02363 457412.RSAG_03430 3.67e-47 154.0 28PBY@1|root,2ZC4G@2|Bacteria,1V2G3@1239|Firmicutes,24HDX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02364 1232447.BAHW02000027_gene2060 2.71e-116 335.0 28KSD@1|root,2ZA9R@2|Bacteria,1UZZ4@1239|Firmicutes,249ZS@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02365 457412.RSAG_03432 1.61e-44 144.0 2E5HW@1|root,33098@2|Bacteria,1VFFD@1239|Firmicutes,24QMD@186801|Clostridia,3WM6E@541000|Ruminococcaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02366 1232447.BAHW02000027_gene2062 1.46e-33 116.0 COG1974@1|root,COG1974@2|Bacteria,1UGUC@1239|Firmicutes,25PEF@186801|Clostridia,26CAC@186813|unclassified Clostridiales 186801|Clostridia KT LexA DNA binding domain - - - - - - - - - - - - LexA_DNA_bind KKPNOBBG_02367 411469.EUBHAL_00463 8.73e-261 719.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,25V11@186806|Eubacteriaceae 186801|Clostridia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH KKPNOBBG_02368 1121333.JMLH01000050_gene629 2.14e-119 347.0 COG1974@1|root,COG1974@2|Bacteria,1UJ92@1239|Firmicutes 1239|Firmicutes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3,Peptidase_S24 KKPNOBBG_02369 1121333.JMLH01000050_gene628 1.48e-28 103.0 COG1476@1|root,COG1476@2|Bacteria,1VCCB@1239|Firmicutes 1239|Firmicutes K transcriptional regulators - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_02370 1235802.C823_01132 0.0 971.0 COG5635@1|root,COG5635@2|Bacteria,1TR89@1239|Firmicutes,24D6H@186801|Clostridia 186801|Clostridia T COG0433 Predicted ATPase - - - - - - - - - - - - - KKPNOBBG_02371 500633.CLOHIR_01306 8.96e-48 157.0 COG0454@1|root,COG0456@2|Bacteria,1VAFS@1239|Firmicutes,24MUI@186801|Clostridia 186801|Clostridia K Acetyltransferase GNAT family - - - ko:K03826 - - - - ko00000,ko01000 - - - Acetyltransf_10,Acetyltransf_7 KKPNOBBG_02372 1121333.JMLH01000050_gene627 1.56e-70 214.0 COG2315@1|root,COG2315@2|Bacteria,1V4K7@1239|Firmicutes,3VQU7@526524|Erysipelotrichia 526524|Erysipelotrichia S YjbR - - - - - - - - - - - - YjbR KKPNOBBG_02373 1121115.AXVN01000155_gene549 4.34e-55 173.0 296J0@1|root,2ZTUJ@2|Bacteria,1V3IP@1239|Firmicutes,24H9K@186801|Clostridia 186801|Clostridia S Bacterial mobilization protein MobC - - - - - - - - - - - - MobC KKPNOBBG_02374 411469.EUBHAL_00458 3.19e-65 211.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,2481D@186801|Clostridia,25VUI@186806|Eubacteriaceae 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - Relaxase KKPNOBBG_02375 999413.HMPREF1094_04392 0.0 1168.0 COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,3VP1E@526524|Erysipelotrichia 526524|Erysipelotrichia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - HNH,Intron_maturas2,RVT_1 KKPNOBBG_02376 1235798.C817_05554 1.65e-140 409.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,2481D@186801|Clostridia,27W44@189330|Dorea 186801|Clostridia U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase KKPNOBBG_02378 658088.HMPREF0987_01089 1.37e-81 250.0 2DZ28@1|root,32V6H@2|Bacteria,1VCMH@1239|Firmicutes,24QBQ@186801|Clostridia,27QVA@186928|unclassified Lachnospiraceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02379 411470.RUMGNA_01486 9.43e-45 148.0 COG1476@1|root,COG1476@2|Bacteria,1UK7B@1239|Firmicutes,25FP1@186801|Clostridia 2|Bacteria K Psort location Cytoplasmic, score 8.87 - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_19,HTH_26,HTH_3,HTH_31 KKPNOBBG_02380 411459.RUMOBE_04188 1.05e-15 73.2 2F99N@1|root,340RC@2|Bacteria,1VX34@1239|Firmicutes,257JQ@186801|Clostridia,3Y26Y@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02381 1410626.JHXB01000025_gene378 5.03e-108 330.0 COG4096@1|root,COG4096@2|Bacteria,1UT4E@1239|Firmicutes,251AT@186801|Clostridia 186801|Clostridia V Type I restriction enzyme R protein N terminus (HSDR_N) - - - - - - - - - - - - HSDR_N_2 KKPNOBBG_02382 1444306.JFZC01000009_gene1910 3.27e-28 108.0 2DMXY@1|root,32UB2@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - KKPNOBBG_02383 908338.HMPREF9286_0988 1.35e-132 401.0 COG1397@1|root,COG4127@1|root,COG1397@2|Bacteria,COG4127@2|Bacteria,1V7HC@1239|Firmicutes,24NRA@186801|Clostridia,22IJI@1570339|Peptoniphilaceae 186801|Clostridia O ADP-ribosylglycohydrolase - - - - - - - - - - - - - KKPNOBBG_02384 1111134.HMPREF1253_0587 9.95e-97 297.0 28HNP@1|root,2Z7WV@2|Bacteria,1TT37@1239|Firmicutes,24FMK@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02386 1121333.JMLH01000037_gene2006 0.0 1659.0 COG1061@1|root,COG1061@2|Bacteria,1U2DR@1239|Firmicutes 1239|Firmicutes L Type III restriction enzyme, res subunit - - - - - - - - - - - - Eco57I,ResIII,T5orf172 KKPNOBBG_02387 1121333.JMLH01000037_gene2007 2.99e-126 370.0 COG1002@1|root,COG1002@2|Bacteria,1TT83@1239|Firmicutes 1239|Firmicutes L restriction endonuclease - - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - Eco57I KKPNOBBG_02388 1305708.M9Q1K0_9CAUD 1.5e-73 226.0 4QBIH@10239|Viruses,4QVPB@35237|dsDNA viruses no RNA stage,4QPU0@28883|Caudovirales,4QM41@10699|Siphoviridae 10699|Siphoviridae S Resolvase, N terminal domain - - - - - - - - - - - - - KKPNOBBG_02390 411469.EUBHAL_00436 6.77e-283 820.0 COG1669@1|root,COG2003@1|root,COG1669@2|Bacteria,COG2003@2|Bacteria,1UICG@1239|Firmicutes 1239|Firmicutes L Domain of unknown function (DUF4316) - - - - - - - - - - - - DUF4316,YodL KKPNOBBG_02391 469596.HMPREF9488_02234 9.94e-41 147.0 COG4509@1|root,COG4509@2|Bacteria,1V7UG@1239|Firmicutes,3VS09@526524|Erysipelotrichia 526524|Erysipelotrichia S Sortase family - - - - - - - - - - - - Sortase KKPNOBBG_02392 1280698.AUJS01000017_gene1815 2.59e-35 132.0 2DNIE@1|root,32XP6@2|Bacteria,1VHU5@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_02393 546273.VEIDISOL_01882 1.9e-98 305.0 COG1236@1|root,COG1236@2|Bacteria,1V168@1239|Firmicutes,4H7MG@909932|Negativicutes 909932|Negativicutes J domain protein - - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B_2,RMMBL KKPNOBBG_02396 1121115.AXVN01000155_gene550 6.57e-131 377.0 COG1051@1|root,COG1051@2|Bacteria,1VD3G@1239|Firmicutes,25MXE@186801|Clostridia,3Y20J@572511|Blautia 186801|Clostridia F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX KKPNOBBG_02397 515620.EUBELI_20144 6.23e-68 207.0 COG5015@1|root,COG5015@2|Bacteria,1V43Y@1239|Firmicutes,24HQB@186801|Clostridia,25WPW@186806|Eubacteriaceae 186801|Clostridia S Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Putative_PNPOx KKPNOBBG_02398 1121333.JMLH01000033_gene2892 0.0 3575.0 COG0553@1|root,COG0827@1|root,COG4646@1|root,COG0553@2|Bacteria,COG0827@2|Bacteria,COG4646@2|Bacteria,1TPQA@1239|Firmicutes,3VNX4@526524|Erysipelotrichia 526524|Erysipelotrichia L Helicase C-terminal domain protein - - - - - - - - - - - - Helicase_C,SNF2_N KKPNOBBG_02399 1042156.CXIVA_10210 2.09e-53 186.0 COG2003@1|root,COG4227@1|root,COG2003@2|Bacteria,COG4227@2|Bacteria,1TQN4@1239|Firmicutes,2482H@186801|Clostridia,36FUP@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - ArdA,DUF3849,DUF4316,Peptidase_M78,YodL KKPNOBBG_02401 1280698.AUJS01000017_gene1791 2.38e-34 120.0 29529@1|root,2ZSF2@2|Bacteria,1W1UD@1239|Firmicutes,254SW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02402 1121333.JMLH01000033_gene2893 5.84e-137 401.0 2DBEA@1|root,2Z8RT@2|Bacteria,1V0Q8@1239|Firmicutes,3VRTZ@526524|Erysipelotrichia 526524|Erysipelotrichia - - - - - - - - - - - - - - - KKPNOBBG_02404 411469.EUBHAL_00430 0.0 2999.0 COG4932@1|root,COG4932@2|Bacteria,1TRG6@1239|Firmicutes,2492K@186801|Clostridia,25VZ7@186806|Eubacteriaceae 186801|Clostridia M Cna protein B-type domain protein - - - - - - - - - - - - Gram_pos_anchor KKPNOBBG_02405 411469.EUBHAL_00428 0.0 1131.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,25VB6@186806|Eubacteriaceae 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - DUF3945,Topoisom_bac,Toprim,Toprim_Crpt KKPNOBBG_02406 411902.CLOBOL_04320 1.09e-112 325.0 COG4725@1|root,COG4725@2|Bacteria,1TSJV@1239|Firmicutes,248X5@186801|Clostridia,21ZSS@1506553|Lachnoclostridium 186801|Clostridia KT Belongs to the MT-A70-like family - - - - - - - - - - - - MT-A70 KKPNOBBG_02407 1232447.BAHW02000027_gene2096 3.41e-203 577.0 COG2433@1|root,COG2433@2|Bacteria,1TPNR@1239|Firmicutes,25BRT@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4366) - - - - - - - - - - - - DUF4366 KKPNOBBG_02408 1232447.BAHW02000027_gene2097 2.28e-30 110.0 2C4J8@1|root,32RE2@2|Bacteria,1V6XK@1239|Firmicutes 1239|Firmicutes S Domain of unknown function (DUF4315) - - - - - - - - - - - - DUF4315 KKPNOBBG_02409 1280698.AUJS01000017_gene1784 0.0 1305.0 COG0739@1|root,COG0791@1|root,COG3584@1|root,COG0739@2|Bacteria,COG0791@2|Bacteria,COG3584@2|Bacteria,1TP24@1239|Firmicutes,247K5@186801|Clostridia,27WB3@189330|Dorea 186801|Clostridia M NlpC/P60 family - - - - - - - - - - - - NLPC_P60,Peptidase_M23 KKPNOBBG_02410 1232447.BAHW02000027_gene2099 0.0 1428.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,248ND@186801|Clostridia,267MD@186813|unclassified Clostridiales 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_10,DUF87 KKPNOBBG_02411 1121333.JMLH01000056_gene1762 5.65e-160 452.0 28HUM@1|root,2Z81B@2|Bacteria,1TNZ2@1239|Firmicutes,3VP2T@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02412 1226322.HMPREF1545_02549 0.0 1062.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,2N670@216572|Oscillospiraceae 186801|Clostridia L Domain of unknown function (DUF4368) - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_02413 1121296.JONJ01000010_gene1996 4.79e-34 117.0 2CM6M@1|root,32SDU@2|Bacteria,1VCHU@1239|Firmicutes,24NMC@186801|Clostridia,2210N@1506553|Lachnoclostridium 186801|Clostridia S Transposon-encoded protein TnpW - - - - - - - - - - - - TnpW KKPNOBBG_02414 1121296.JONJ01000010_gene1995 1.12e-207 573.0 COG1484@1|root,COG1484@2|Bacteria,1TPZX@1239|Firmicutes,248F0@186801|Clostridia,21ZQ3@1506553|Lachnoclostridium 186801|Clostridia L IstB-like ATP binding protein - - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 KKPNOBBG_02415 1121296.JONJ01000010_gene1994 1.08e-167 469.0 COG3935@1|root,COG3935@2|Bacteria,1TQ65@1239|Firmicutes,249Q8@186801|Clostridia,21Z5B@1506553|Lachnoclostridium 186801|Clostridia L N-terminal phage replisome organiser (Phage_rep_org_N) - - - - - - - - - - - - Phage_rep_org_N KKPNOBBG_02416 411468.CLOSCI_00110 0.0 1063.0 COG3843@1|root,COG3843@2|Bacteria,1TR9B@1239|Firmicutes,24A36@186801|Clostridia,21ZMD@1506553|Lachnoclostridium 186801|Clostridia U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase KKPNOBBG_02417 1232452.BAIB02000008_gene1934 4.42e-87 256.0 2C2YH@1|root,2ZBKZ@2|Bacteria,1V3N8@1239|Firmicutes,24FYJ@186801|Clostridia,26B66@186813|unclassified Clostridiales 186801|Clostridia S Bacterial mobilisation protein (MobC) - - - - - - - - - - - - MobC KKPNOBBG_02418 1226322.HMPREF1545_02540 3.87e-42 137.0 2DIHV@1|root,303BZ@2|Bacteria,1TU2R@1239|Firmicutes,257WJ@186801|Clostridia,2N8UZ@216572|Oscillospiraceae 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_16 KKPNOBBG_02419 1226322.HMPREF1545_02538 1.42e-102 296.0 COG1595@1|root,COG1595@2|Bacteria,1TSKU@1239|Firmicutes,24CQA@186801|Clostridia,2N8MP@216572|Oscillospiraceae 186801|Clostridia K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r4 KKPNOBBG_02420 1226322.HMPREF1545_02537 1.39e-182 508.0 COG0500@1|root,COG2226@2|Bacteria,1TR6N@1239|Firmicutes,2494W@186801|Clostridia 186801|Clostridia Q Psort location Cytoplasmic, score - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 KKPNOBBG_02421 742740.HMPREF9474_04642 1.92e-97 284.0 COG1476@1|root,COG1476@2|Bacteria,1UYK7@1239|Firmicutes,24GQU@186801|Clostridia,221FS@1506553|Lachnoclostridium 186801|Clostridia K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 KKPNOBBG_02422 1042156.CXIVA_10010 0.0 1232.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae 186801|Clostridia J elongation factor G - - - ko:K18220 - - - - br01600,ko00000,ko01504 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU KKPNOBBG_02424 1232452.BAIB02000009_gene1940 6.55e-273 749.0 COG0738@1|root,COG0738@2|Bacteria,1UJ6C@1239|Firmicutes,2494T@186801|Clostridia 186801|Clostridia G Major Facilitator Superfamily - - - ko:K18214 - - - - ko00000,ko01504,ko02000 2.A.1.21.6 - - MFS_1 KKPNOBBG_02425 1232447.BAHW02000027_gene2103 0.0 1047.0 COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,2489C@186801|Clostridia 186801|Clostridia U COG COG3505 Type IV secretory pathway, VirD4 components - - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf,TraG-D_C KKPNOBBG_02426 1121333.JMLH01000056_gene1759 3.4e-90 266.0 28I1B@1|root,2Z860@2|Bacteria,1TT6W@1239|Firmicutes,3VQTZ@526524|Erysipelotrichia 526524|Erysipelotrichia S Protein of unknown function (DUF3801) - - - - - - - - - - - - DUF3801 KKPNOBBG_02427 411469.EUBHAL_00417 7.82e-155 438.0 COG1484@1|root,COG1484@2|Bacteria,1TPZX@1239|Firmicutes,248F0@186801|Clostridia,25VAQ@186806|Eubacteriaceae 186801|Clostridia L Psort location Cytoplasmic, score - - - ko:K02315 - - - - ko00000,ko03032 - - - IstB_IS21 KKPNOBBG_02428 411469.EUBHAL_00416 1.46e-111 329.0 2DBC6@1|root,2Z8BZ@2|Bacteria,1TQXM@1239|Firmicutes,2484N@186801|Clostridia,25WTZ@186806|Eubacteriaceae 186801|Clostridia S Replication initiator protein A (RepA) N-terminus repA - - - - - - - - - - - RepA_N KKPNOBBG_02429 1232447.BAHW02000027_gene2107 1.8e-79 250.0 2DUSC@1|root,33S0A@2|Bacteria,1VSUV@1239|Firmicutes 1239|Firmicutes S Replication initiator protein A (RepA) N-terminus - - - - - - - - - - - - RepA_N KKPNOBBG_02430 1121333.JMLH01000056_gene1755 6.77e-42 142.0 28PSR@1|root,2ZCE7@2|Bacteria,1V1ED@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_02431 1121333.JMLH01000056_gene1754 7.84e-72 218.0 COG0629@1|root,COG0629@2|Bacteria,1V3AF@1239|Firmicutes 1239|Firmicutes L Single-strand binding protein family - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB KKPNOBBG_02432 1121333.JMLH01000056_gene1753 5.42e-63 195.0 2EY74@1|root,33RFP@2|Bacteria,1VR6Q@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_02433 1232447.BAHW02000027_gene2111 1.15e-39 134.0 2BAQE@1|root,32NWD@2|Bacteria,1V8VM@1239|Firmicutes,24WJV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02434 1121333.JMLH01000056_gene1749 1.58e-151 433.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,3VQ3M@526524|Erysipelotrichia 526524|Erysipelotrichia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - ParBc KKPNOBBG_02435 1121333.JMLH01000056_gene1748 9.63e-151 428.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,3VPAB@526524|Erysipelotrichia 526524|Erysipelotrichia D CobQ CobB MinD ParA nucleotide binding domain protein - - - - - - - - - - - - AAA_31 KKPNOBBG_02436 203119.Cthe_1385 1.25e-06 60.5 COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WGPN@541000|Ruminococcaceae 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW KKPNOBBG_02437 397290.C810_02638 1.72e-23 98.6 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,248JG@186801|Clostridia,27JKE@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,HhH-GPD,Transposase_20 KKPNOBBG_02438 536227.CcarbDRAFT_1707 1.95e-66 233.0 2FAT1@1|root,34309@2|Bacteria,1VWQB@1239|Firmicutes,251IU@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02439 33035.JPJF01000130_gene1068 8.96e-317 865.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3XZ78@572511|Blautia 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr KKPNOBBG_02440 33035.JPJF01000130_gene1069 6.64e-23 90.1 2E4IR@1|root,32ZDT@2|Bacteria,1VENP@1239|Firmicutes,24NT8@186801|Clostridia,3Y0CG@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02441 33035.JPJF01000130_gene1070 0.0 1419.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3XZD3@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C KKPNOBBG_02442 33035.JPJF01000036_gene1745 4.02e-131 373.0 COG0789@1|root,COG0789@2|Bacteria,1V1M9@1239|Firmicutes,24FUE@186801|Clostridia,3XZ5N@572511|Blautia 186801|Clostridia K COG NOG13858 non supervised orthologous group - - - - - - - - - - - - DUF1836 KKPNOBBG_02443 1144888.CM001467_gene241 0.000622 45.1 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,47FHH@766|Rickettsiales 766|Rickettsiales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 KKPNOBBG_02444 1410624.JNKK01000018_gene2031 7.73e-181 527.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,27IV1@186928|unclassified Lachnospiraceae 186801|Clostridia M BCCT, betaine/carnitine/choline family transporter - - - - - - - - - - - - BCCT KKPNOBBG_02445 1347369.CCAD010000083_gene2765 7.37e-188 550.0 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,4HFIP@91061|Bacilli,1ZD3I@1386|Bacillus 1239|Firmicutes C COG2414 Aldehyde ferredoxin oxidoreductase - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N KKPNOBBG_02447 1226322.HMPREF1545_02902 1.56e-224 625.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,2N6WZ@216572|Oscillospiraceae 186801|Clostridia C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic KKPNOBBG_02448 1095749.HMPREF1052_0051 3.31e-139 415.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,1RP5Z@1236|Gammaproteobacteria,1Y7KC@135625|Pasteurellales 1236|Gammaproteobacteria E Aspartate ammonia-lyase - - - - - - - - - - - - Lyase_1 KKPNOBBG_02449 1121085.AUCI01000024_gene186 1.07e-32 127.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,4HCSI@91061|Bacilli,1ZDR0@1386|Bacillus 91061|Bacilli K Transcriptional regulator - - - ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR KKPNOBBG_02450 1132442.KB889752_gene2713 7.39e-185 523.0 COG1062@1|root,COG1062@2|Bacteria,1TP8E@1239|Firmicutes,4HAH9@91061|Bacilli,1ZAXJ@1386|Bacillus 91061|Bacilli C Zinc-binding dehydrogenase - - 1.1.1.1,1.1.1.284,1.1.1.90 ko:K00055,ko:K00121 ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 M00537,M00538 R00623,R00754,R01763,R02124,R02611,R04304,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_02451 1122915.AUGY01000090_gene5341 5.72e-136 403.0 COG1027@1|root,COG1027@2|Bacteria,1TP3U@1239|Firmicutes,4HFM9@91061|Bacilli,26RDY@186822|Paenibacillaceae 91061|Bacilli E Aspartate ammonia-lyase aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 KKPNOBBG_02452 742741.HMPREF9475_02716 1.05e-49 174.0 COG0523@1|root,COG3689@1|root,COG0523@2|Bacteria,COG3689@2|Bacteria,1TS8P@1239|Firmicutes,248DY@186801|Clostridia,21YDS@1506553|Lachnoclostridium 186801|Clostridia S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - cobW KKPNOBBG_02453 189426.PODO_26280 4.22e-26 112.0 COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,4HDBC@91061|Bacilli,26TJF@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02454 994573.T472_0217130 1.65e-52 176.0 COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,36GDP@31979|Clostridiaceae 186801|Clostridia H UBA THIF-type NAD FAD binding protein moeB - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF KKPNOBBG_02455 931626.Awo_c12580 1.62e-59 202.0 COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,25YA3@186806|Eubacteriaceae 186801|Clostridia C FAD dependent oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 KKPNOBBG_02456 610130.Closa_4102 1.6e-93 298.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,21XTX@1506553|Lachnoclostridium 186801|Clostridia S FAD dependent oxidoreductase - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD KKPNOBBG_02457 471855.Shel_24590 3.72e-271 764.0 COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,2H5ET@201174|Actinobacteria,4CV54@84998|Coriobacteriia 84998|Coriobacteriia H molybdopterin binding domain - - 2.10.1.1 ko:K03750,ko:K07219 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_N KKPNOBBG_02458 471855.Shel_24600 1.67e-122 367.0 COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4CV83@84998|Coriobacteriia 201174|Actinobacteria H Molybdenum cofactor synthesis domain protein - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N KKPNOBBG_02459 471855.Shel_27140 1.01e-60 204.0 COG2998@1|root,COG2998@2|Bacteria,2IHMF@201174|Actinobacteria 201174|Actinobacteria H PBP superfamily domain - - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 KKPNOBBG_02460 1235798.C817_00453 7.64e-79 239.0 COG0778@1|root,COG0778@2|Bacteria,1V4K6@1239|Firmicutes,24B09@186801|Clostridia,27VY0@189330|Dorea 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase KKPNOBBG_02461 1123372.AUIT01000012_gene1668 5.51e-46 159.0 COG4662@1|root,COG4662@2|Bacteria,2GGWW@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria H Binding-protein-dependent transport system inner membrane component - - - ko:K05773 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - BPD_transp_1 KKPNOBBG_02462 335541.Swol_1631 6.14e-35 131.0 COG1117@1|root,COG1117@2|Bacteria,1UJJD@1239|Firmicutes,25F4F@186801|Clostridia,42JV1@68298|Syntrophomonadaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - 3.6.3.55 ko:K06857 ko02010,map02010 M00186 R10531 RC00002 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.6.2,3.A.1.6.4 - - ABC_tran KKPNOBBG_02463 33035.JPJF01000036_gene1746 1.66e-143 408.0 COG1511@1|root,COG1511@2|Bacteria,1TPFN@1239|Firmicutes,24DWU@186801|Clostridia 186801|Clostridia S ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane KKPNOBBG_02464 33035.JPJF01000036_gene1747 3.42e-152 430.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,3Y07P@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran KKPNOBBG_02465 33035.JPJF01000036_gene1748 2.93e-95 279.0 COG1476@1|root,COG1476@2|Bacteria,1UUV5@1239|Firmicutes,25KCX@186801|Clostridia,3Y0TB@572511|Blautia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_02466 97139.C824_04942 1.52e-61 213.0 COG3290@1|root,COG3290@2|Bacteria,1UYTM@1239|Firmicutes,24CUA@186801|Clostridia,36FUX@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - 2.7.13.3 ko:K07706 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c_5 KKPNOBBG_02467 1235802.C823_01706 8.22e-45 157.0 COG3279@1|root,COG3279@2|Bacteria,1V392@1239|Firmicutes,248ZQ@186801|Clostridia,25Y3I@186806|Eubacteriaceae 186801|Clostridia K LytTr DNA-binding domain - - - ko:K07707 ko02020,ko02024,map02020,map02024 M00495 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg KKPNOBBG_02468 33035.JPJF01000036_gene1749 7.96e-148 417.0 COG1309@1|root,COG1309@2|Bacteria,1VQ88@1239|Firmicutes 1239|Firmicutes K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_02469 33035.JPJF01000036_gene1750 1.33e-160 450.0 COG1143@1|root,COG1143@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4,Fer4_4,Fer4_8,Putative_PNPOx KKPNOBBG_02470 33035.JPJF01000036_gene1751 1.08e-304 832.0 COG0531@1|root,COG0531@2|Bacteria,1V0MG@1239|Firmicutes,25JEH@186801|Clostridia,3Y1KU@572511|Blautia 1239|Firmicutes E Amino acid permease - - - - - - - - - - - - AA_permease_2 KKPNOBBG_02471 33035.JPJF01000036_gene1752 3.55e-162 454.0 COG5015@1|root,COG5015@2|Bacteria,1TR2Q@1239|Firmicutes,24A68@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - Fer4,Putative_PNPOx KKPNOBBG_02472 33035.JPJF01000036_gene1753 9.03e-127 360.0 COG1917@1|root,COG1917@2|Bacteria,1W36M@1239|Firmicutes,257HZ@186801|Clostridia 186801|Clostridia S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - KKPNOBBG_02473 33035.JPJF01000036_gene1754 2.56e-66 201.0 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,3Y07E@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Trp_repressor KKPNOBBG_02474 33035.JPJF01000036_gene1755 2.67e-163 457.0 COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,3XYKS@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - - ko:K04477 - - - - ko00000 - - - PHP KKPNOBBG_02475 33035.JPJF01000036_gene1756 0.0 975.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XYSC@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_02476 33035.JPJF01000036_gene1757 0.0 986.0 COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia,3XZ0K@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Fucose_iso_C KKPNOBBG_02477 33035.JPJF01000036_gene1758 2.07e-144 407.0 28PTU@1|root,2ZCEZ@2|Bacteria,1U95M@1239|Firmicutes,247W6@186801|Clostridia,3XZXH@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4867) - - - - - - - - - - - - DUF4867 KKPNOBBG_02478 33035.JPJF01000036_gene1759 2.66e-109 317.0 COG0834@1|root,COG0834@2|Bacteria,1UE9Q@1239|Firmicutes,25J53@186801|Clostridia,3Y1V9@572511|Blautia 186801|Clostridia ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02424 ko02010,map02010 M00234 - - ko00000,ko00001,ko00002,ko02000,ko02035 3.A.1.3.10,3.A.1.3.14 - - SBP_bac_3 KKPNOBBG_02479 33035.JPJF01000008_gene1233 1.03e-214 594.0 COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,3XYHJ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 ytqA - - ko:K07139 - - - - ko00000 - - - Radical_SAM,Radical_SAM_C KKPNOBBG_02480 33035.JPJF01000008_gene1232 1.03e-98 288.0 COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia,3Y078@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4364 KKPNOBBG_02481 33035.JPJF01000008_gene1231 7.86e-302 825.0 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,3XZ05@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N KKPNOBBG_02482 33035.JPJF01000008_gene1230 7.13e-158 443.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,24H9B@186801|Clostridia,3XZX4@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Polysacc_deac_1 KKPNOBBG_02483 33035.JPJF01000008_gene1229 3.72e-126 360.0 COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,24CNE@186801|Clostridia 186801|Clostridia E PFAM Lysine exporter protein (LYSE YGGA) - - - ko:K11249 - - - - ko00000,ko02000 2.A.76.1.4 - - LysE KKPNOBBG_02484 33035.JPJF01000008_gene1228 0.0 2702.0 COG1593@1|root,COG1638@1|root,COG1593@2|Bacteria,COG1638@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,3XZAD@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DctM,DctP KKPNOBBG_02485 33035.JPJF01000008_gene1227 8.44e-107 309.0 COG3090@1|root,COG3090@2|Bacteria,1V6P9@1239|Firmicutes,24JKS@186801|Clostridia,3XZTR@572511|Blautia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ KKPNOBBG_02486 33035.JPJF01000008_gene1225 1.39e-72 218.0 COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,3Y03U@572511|Blautia 186801|Clostridia J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 KKPNOBBG_02487 537007.BLAHAN_06860 4e-32 112.0 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,3Y0PB@572511|Blautia 186801|Clostridia J Psort location Extracellular, score 8.82 rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p KKPNOBBG_02488 33035.JPJF01000008_gene1224 4.22e-105 304.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,3XZXW@572511|Blautia 186801|Clostridia J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N KKPNOBBG_02489 33035.JPJF01000008_gene1223 5.58e-306 836.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3XYZK@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF KKPNOBBG_02490 33035.JPJF01000008_gene1222 9.89e-74 220.0 2DP3R@1|root,330E2@2|Bacteria,1VEPT@1239|Firmicutes,24QJB@186801|Clostridia,3Y0IT@572511|Blautia 186801|Clostridia S COG NOG16856 non supervised orthologous group - - - - - - - - - - - - DUF1540 KKPNOBBG_02491 33035.JPJF01000008_gene1221 0.0 1242.0 COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3XYSJ@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 10.00 thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD KKPNOBBG_02492 33035.JPJF01000008_gene1220 0.0 1736.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3XZQG@572511|Blautia 186801|Clostridia KL Psort location Cytoplasmic, score 8.87 - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM KKPNOBBG_02493 33035.JPJF01000008_gene1219 2.98e-150 426.0 COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia,3Y08M@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - DUF218 KKPNOBBG_02494 33035.JPJF01000008_gene1218 5.12e-117 335.0 COG0653@1|root,COG3012@1|root,COG0653@2|Bacteria,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,3XZU8@572511|Blautia 186801|Clostridia U Psort location Cytoplasmic, score 8.87 secA_2 - - - - - - - - - - - SEC-C KKPNOBBG_02495 33035.JPJF01000008_gene1217 1.3e-251 694.0 COG0673@1|root,COG0673@2|Bacteria,1V0JH@1239|Firmicutes,249FB@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_02496 33035.JPJF01000008_gene1216 1.33e-135 391.0 COG2207@1|root,COG2207@2|Bacteria,1UYFM@1239|Firmicutes,247WN@186801|Clostridia,3XZJ7@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_02497 33035.JPJF01000035_gene3485 0.0 1220.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3XYX5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_02498 658086.HMPREF0994_01111 1.97e-189 546.0 COG1874@1|root,COG1874@2|Bacteria,1UZ5Q@1239|Firmicutes,24CFY@186801|Clostridia,27REH@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 KKPNOBBG_02499 180332.JTGN01000005_gene2973 7.71e-168 473.0 COG0395@1|root,COG0395@2|Bacteria,1TRUD@1239|Firmicutes,24CGW@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_02500 180332.JTGN01000005_gene2974 1.11e-164 464.0 COG1175@1|root,COG1175@2|Bacteria 2|Bacteria P transmembrane transport - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 KKPNOBBG_02501 180332.JTGN01000005_gene2975 2.36e-217 607.0 COG1653@1|root,COG1653@2|Bacteria,1V10D@1239|Firmicutes,24EK2@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_02502 180332.JTGN01000005_gene2977 5.12e-170 484.0 COG1609@1|root,COG1609@2|Bacteria,1UYM8@1239|Firmicutes,24BYD@186801|Clostridia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_3 KKPNOBBG_02503 33035.JPJF01000010_gene1259 3.58e-144 419.0 COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia,3XZWW@572511|Blautia 186801|Clostridia C Iron-sulfur cluster-binding domain - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SEC-C,SPASM KKPNOBBG_02504 397291.C804_02752 1.13e-199 567.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,27IA1@186928|unclassified Lachnospiraceae 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_02505 658086.HMPREF0994_03620 0.0 956.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,25AWC@186801|Clostridia,27R5N@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 38 C-terminal domain - - - - - - - - - - - - Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_02506 397291.C804_02747 8.87e-261 723.0 COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,24AB0@186801|Clostridia,27K8B@186928|unclassified Lachnospiraceae 186801|Clostridia G Sucrose phosphorylase - GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.329 ko:K21350 - - - - ko00000,ko01000 - GH13 - Alpha-amylase KKPNOBBG_02507 33035.JPJF01000059_gene3007 2.32e-299 816.0 COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,3Y1G1@572511|Blautia 186801|Clostridia Q Amidohydrolase family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 KKPNOBBG_02508 33035.JPJF01000059_gene3008 8.54e-214 590.0 COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,3Y0Y3@572511|Blautia 186801|Clostridia E Formiminotransferase domain, N-terminal subdomain ftcD - 2.1.2.5 ko:K00603 ko00340,ko00670,ko01100,map00340,map00670,map01100 - R02287,R03189 RC00165,RC00221,RC00223,RC00870 ko00000,ko00001,ko01000 - - - FTCD,FTCD_N KKPNOBBG_02509 33035.JPJF01000059_gene3009 4.41e-127 363.0 COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,3Y154@572511|Blautia 186801|Clostridia E Formiminotransferase-cyclodeaminase fchA - 4.3.1.4 ko:K01746 ko00670,ko01100,map00670,map01100 - R02302 RC00688 ko00000,ko00001,ko01000 - - - FTCD_C KKPNOBBG_02510 33035.JPJF01000059_gene3010 7.09e-53 166.0 COG3052@1|root,COG3052@2|Bacteria,1VEZZ@1239|Firmicutes,24QMJ@186801|Clostridia,3Y1SC@572511|Blautia 186801|Clostridia C Malonate decarboxylase delta subunit (MdcD) citD - - ko:K01646 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001 - - - ACP KKPNOBBG_02511 33035.JPJF01000059_gene3011 2.33e-204 566.0 COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,3Y0KU@572511|Blautia 186801|Clostridia G Belongs to the HpcH HpaI aldolase family citE - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI KKPNOBBG_02512 33035.JPJF01000059_gene3012 0.0 888.0 COG3051@1|root,COG3051@2|Bacteria,1TPN3@1239|Firmicutes,247QD@186801|Clostridia,3Y18V@572511|Blautia 186801|Clostridia C Citrate lyase, alpha subunit (CitF) citF - 2.8.3.10 ko:K01643 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS19975 CitF KKPNOBBG_02513 33035.JPJF01000059_gene3013 6.05e-98 285.0 COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia,3Y1IG@572511|Blautia 186801|Clostridia I B12 binding domain mamA - 5.4.99.1 ko:K01846 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - B12-binding KKPNOBBG_02514 33035.JPJF01000059_gene3014 0.0 889.0 COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,3Y1AA@572511|Blautia 186801|Clostridia D MutL protein mutL2 - - - - - - - - - - - MutL KKPNOBBG_02515 33035.JPJF01000059_gene3015 0.0 944.0 COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,24AYE@186801|Clostridia,3Y11W@572511|Blautia 186801|Clostridia E Methylaspartate mutase E chain (MutE) glmE - 5.4.99.1 ko:K19268 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R00262 RC01221 ko00000,ko00001,ko00002,ko01000 - - - Met_asp_mut_E KKPNOBBG_02516 33035.JPJF01000059_gene3016 4.52e-301 821.0 COG3799@1|root,COG3799@2|Bacteria,1TQ7T@1239|Firmicutes,247VB@186801|Clostridia,3Y17G@572511|Blautia 186801|Clostridia E Methylaspartate ammonia-lyase N-terminus - - 4.3.1.2 ko:K04835 ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200 M00740 R03696 RC00979 ko00000,ko00001,ko00002,ko01000 - - - MAAL_C,MAAL_N KKPNOBBG_02517 33035.JPJF01000059_gene3017 4.66e-230 632.0 COG0441@1|root,COG0441@2|Bacteria,1TPW5@1239|Firmicutes,24B69@186801|Clostridia 186801|Clostridia J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) - - - - - - - - - - - - - KKPNOBBG_02518 33035.JPJF01000059_gene3018 3.28e-194 539.0 COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,3XZ8S@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 fumA - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase KKPNOBBG_02519 33035.JPJF01000059_gene3019 8.02e-119 340.0 COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,3XZI9@572511|Blautia 186801|Clostridia C COG COG1838 Tartrate dehydratase beta subunit Fumarate hydratase class I, C-terminal domain fumB - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C KKPNOBBG_02520 33035.JPJF01000059_gene3021 8.01e-178 498.0 2BZUE@1|root,33RE4@2|Bacteria,1VS46@1239|Firmicutes,259VV@186801|Clostridia,3Y0S0@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02521 33035.JPJF01000059_gene3022 7.94e-155 439.0 COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,3Y1XS@572511|Blautia 186801|Clostridia S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B KKPNOBBG_02522 33035.JPJF01000059_gene3023 3.37e-178 497.0 28NW4@1|root,30Q9J@2|Bacteria,1V4ZJ@1239|Firmicutes,24GHA@186801|Clostridia,3XZZE@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - SseB KKPNOBBG_02523 33035.JPJF01000059_gene3024 1.9e-191 531.0 COG2159@1|root,COG2159@2|Bacteria,1W7C1@1239|Firmicutes,258X3@186801|Clostridia,3Y255@572511|Blautia 186801|Clostridia S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 KKPNOBBG_02524 33035.JPJF01000059_gene3025 3.07e-196 544.0 COG0613@1|root,COG0613@2|Bacteria,1V46R@1239|Firmicutes,24BEJ@186801|Clostridia,3XZ88@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PHP,PHP_C KKPNOBBG_02525 33035.JPJF01000059_gene3026 1.65e-301 823.0 COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,3XZMY@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 KKPNOBBG_02526 33035.JPJF01000059_gene3027 7.4e-248 685.0 COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,3XZ3U@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 alaXL - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD KKPNOBBG_02527 33035.JPJF01000059_gene3028 1.91e-257 707.0 COG1735@1|root,COG1735@2|Bacteria,1TS8I@1239|Firmicutes,249N0@186801|Clostridia,3Y0WE@572511|Blautia 186801|Clostridia S Phosphotriesterase family - - - ko:K07048 - - - - ko00000 - - - PTE KKPNOBBG_02528 33035.JPJF01000013_gene4583 6.3e-173 490.0 COG5464@1|root,COG5464@2|Bacteria,1V3CA@1239|Firmicutes,24H4R@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Transposase_31 KKPNOBBG_02529 476272.RUMHYD_01536 7.18e-90 275.0 COG1321@1|root,COG1321@2|Bacteria,1V7A4@1239|Firmicutes,24KT5@186801|Clostridia 186801|Clostridia K Iron dependent repressor, metal binding and dimerisation domain - - - - - - - - - - - - Fe_dep_repr_C KKPNOBBG_02530 476272.RUMHYD_01537 6.85e-114 336.0 COG1846@1|root,COG1846@2|Bacteria,1V7D4@1239|Firmicutes,24KBM@186801|Clostridia 186801|Clostridia K Transcriptional regulator - - - - - - - - - - - - - KKPNOBBG_02532 742765.HMPREF9457_02330 3.07e-289 914.0 COG1196@1|root,COG4886@1|root,COG1196@2|Bacteria,COG4886@2|Bacteria,1V920@1239|Firmicutes,24K33@186801|Clostridia 186801|Clostridia D Iron transport-associated domain protein - - - - - - - - - - - - FIVAR,NEAT KKPNOBBG_02533 476272.RUMHYD_01538 1.4e-118 353.0 2DXCZ@1|root,32V38@2|Bacteria,1V85R@1239|Firmicutes,25D9P@186801|Clostridia,3Y0ZY@572511|Blautia 186801|Clostridia S Cell surface heme-binding protein Shp - - - - - - - - - - - - HemeBinding_Shp KKPNOBBG_02534 476272.RUMHYD_01539 5.22e-172 491.0 COG0614@1|root,COG0614@2|Bacteria,1UIJ9@1239|Firmicutes,24C58@186801|Clostridia,3Y14X@572511|Blautia 186801|Clostridia P Periplasmic binding protein isdE - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 KKPNOBBG_02535 476272.RUMHYD_01540 4.86e-173 492.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,24BGM@186801|Clostridia,3Y1D1@572511|Blautia 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fhuB - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD KKPNOBBG_02536 476272.RUMHYD_01541 1.12e-149 426.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3XZZ8@572511|Blautia 186801|Clostridia HP ATPases associated with a variety of cellular activities fhuC - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran KKPNOBBG_02537 476272.RUMHYD_01542 7.82e-64 198.0 COG2832@1|root,COG2832@2|Bacteria,1VEWF@1239|Firmicutes,24JN1@186801|Clostridia,3Y0NI@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K09790 - - - - ko00000 - - - DUF454 KKPNOBBG_02538 476272.RUMHYD_01544 8.93e-273 764.0 COG4988@1|root,COG4988@2|Bacteria,1TQ1P@1239|Firmicutes,248SV@186801|Clostridia,3XYXJ@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score cydD - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_02539 515620.EUBELI_20240 5.15e-285 793.0 COG1132@1|root,COG1132@2|Bacteria,1UHQP@1239|Firmicutes,25E4H@186801|Clostridia,25UYA@186806|Eubacteriaceae 186801|Clostridia V ABC transporter transmembrane region cydC - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran KKPNOBBG_02540 33035.JPJF01000059_gene3031 0.0 1093.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia,3XZ7N@572511|Blautia 186801|Clostridia S COG COG0488 ATPase components of ABC transporters with duplicated ATPase domains yfmR - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn KKPNOBBG_02541 33035.JPJF01000059_gene3032 1.21e-199 555.0 arCOG12964@1|root,2Z7HP@2|Bacteria,1UZIT@1239|Firmicutes,24G0N@186801|Clostridia,3Y1MB@572511|Blautia 186801|Clostridia S Tocopherol cyclase - - - - - - - - - - - - Tocopherol_cycl KKPNOBBG_02542 33035.JPJF01000059_gene3033 4.32e-78 233.0 COG1733@1|root,COG1733@2|Bacteria,1VCB0@1239|Firmicutes,25CM9@186801|Clostridia 186801|Clostridia K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR KKPNOBBG_02543 33035.JPJF01000059_gene3034 0.0 1353.0 COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,3XYJU@572511|Blautia 186801|Clostridia O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C KKPNOBBG_02544 33035.JPJF01000059_gene3036 0.0 1494.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3XZ9E@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - ko:K12952 - - - - ko00000,ko01000 3.A.3.23 - - E1-E2_ATPase,Hydrolase KKPNOBBG_02545 457421.CBFG_03911 2.22e-115 350.0 COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,24GF0@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_18,HTH_AraC KKPNOBBG_02546 742733.HMPREF9469_05529 1.55e-116 343.0 COG0546@1|root,COG0546@2|Bacteria,1V1RB@1239|Firmicutes,2487B@186801|Clostridia,21YYT@1506553|Lachnoclostridium 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 KKPNOBBG_02547 457421.CBFG_03913 0.0 938.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,268GX@186813|unclassified Clostridiales 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 KKPNOBBG_02548 742733.HMPREF9469_05527 1.92e-235 659.0 COG2211@1|root,COG2211@2|Bacteria,1TRYR@1239|Firmicutes,25C8G@186801|Clostridia,22484@1506553|Lachnoclostridium 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_02549 478749.BRYFOR_06575 1.19e-250 692.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia 186801|Clostridia C 'glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2,Pyr_redox_3 KKPNOBBG_02550 755731.Clo1100_0972 1.85e-130 379.0 2DB8K@1|root,2Z7S1@2|Bacteria,1TRA1@1239|Firmicutes,24886@186801|Clostridia,36FHZ@31979|Clostridiaceae 186801|Clostridia H Streptomycin adenylyltransferase - - - ko:K05593 - - - - ko00000,ko01000,ko01504 - - - Adenyl_transf KKPNOBBG_02551 33035.JPJF01000059_gene3038 9.23e-137 391.0 2BD2V@1|root,326QD@2|Bacteria,1USKQ@1239|Firmicutes,2584W@186801|Clostridia,3Y24G@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02552 33035.JPJF01000059_gene3039 4.51e-56 175.0 COG4430@1|root,COG4430@2|Bacteria,1VA6D@1239|Firmicutes,24N9F@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF1905) - - - - - - - - - - - - DUF1905,OmdA KKPNOBBG_02553 33035.JPJF01000059_gene3040 1.31e-163 462.0 COG5464@1|root,COG5464@2|Bacteria,1V394@1239|Firmicutes,24GXK@186801|Clostridia,3Y2CV@572511|Blautia 186801|Clostridia S PD-(D/E)XK nuclease family transposase - - - - - - - - - - - - PDDEXK_2 KKPNOBBG_02554 33035.JPJF01000059_gene3041 0.0 1071.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia 186801|Clostridia E Family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_02555 33035.JPJF01000059_gene3042 5e-209 580.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3Y02S@572511|Blautia 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_02556 33035.JPJF01000059_gene3043 3.7e-203 563.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZYG@572511|Blautia 186801|Clostridia EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K02034,ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N KKPNOBBG_02557 33035.JPJF01000059_gene3044 2.57e-224 619.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3XZ1P@572511|Blautia 186801|Clostridia EP Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02031,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_02558 33035.JPJF01000059_gene3045 2.16e-238 655.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3XZ61@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_02559 33035.JPJF01000059_gene3049 0.0 1792.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia 186801|Clostridia V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran KKPNOBBG_02560 33035.JPJF01000059_gene3050 7.64e-129 368.0 COG1309@1|root,COG1309@2|Bacteria,1VG7Q@1239|Firmicutes,24RQP@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_02561 33035.JPJF01000059_gene3051 9.68e-292 796.0 COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,3XYJB@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK KKPNOBBG_02562 33035.JPJF01000059_gene3052 0.0 941.0 COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,3XZBZ@572511|Blautia 186801|Clostridia E Orn Lys Arg decarboxylase, major domain protein speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - OKR_DC_1,OKR_DC_1_C KKPNOBBG_02563 500632.CLONEX_02169 4.77e-186 519.0 COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia 186801|Clostridia H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synt_N,Spermine_synth KKPNOBBG_02564 33035.JPJF01000059_gene3055 2.38e-190 530.0 COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,3XYTI@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase KKPNOBBG_02565 33035.JPJF01000059_gene3056 1.09e-293 801.0 COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia,3XYN8@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 LYS1 - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP KKPNOBBG_02566 33035.JPJF01000059_gene3057 9.43e-259 710.0 COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia,3XYIP@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 nspC - 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC KKPNOBBG_02567 33035.JPJF01000059_gene3063 4.26e-212 587.0 COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,3XZ5J@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 fba - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase KKPNOBBG_02568 33035.JPJF01000059_gene3065 3.4e-303 829.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3Y18Z@572511|Blautia 186801|Clostridia E Sodium:alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp KKPNOBBG_02569 33035.JPJF01000059_gene3066 1.74e-222 613.0 COG4189@1|root,COG4189@2|Bacteria,1TPGD@1239|Firmicutes,248UW@186801|Clostridia 186801|Clostridia K regulatory protein, arsR - - - - - - - - - - - - HTH_20 KKPNOBBG_02570 33035.JPJF01000011_gene1366 0.0 1178.0 COG3250@1|root,COG3250@2|Bacteria,1TQAM@1239|Firmicutes,248XS@186801|Clostridia,3Y0FZ@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_02571 33035.JPJF01000011_gene1365 0.0 911.0 COG3263@1|root,COG3263@2|Bacteria,1TQPJ@1239|Firmicutes,2486W@186801|Clostridia,3XYNK@572511|Blautia 186801|Clostridia P Sodium/hydrogen exchanger family - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger,TrkA_C KKPNOBBG_02572 33035.JPJF01000015_gene4936 1.19e-37 126.0 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,24QJ1@186801|Clostridia 186801|Clostridia K DNA-binding helix-turn-helix protein - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 KKPNOBBG_02573 33035.JPJF01000015_gene4937 9.4e-103 302.0 28P2J@1|root,2ZBYK@2|Bacteria,1V6UQ@1239|Firmicutes,249N5@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3796) - - - - - - - - - - - - DUF3796 KKPNOBBG_02574 33035.JPJF01000015_gene4938 1.13e-305 835.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3XYP7@572511|Blautia 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C KKPNOBBG_02575 33035.JPJF01000015_gene4939 7.84e-91 267.0 COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,3XZYF@572511|Blautia 186801|Clostridia J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N KKPNOBBG_02576 33035.JPJF01000015_gene4940 0.0 1279.0 COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia,3XYI8@572511|Blautia 186801|Clostridia T signaling protein consisting of a modified GGDEF domain and a DHH domain yybT - - - - - - - - - - - DHH,DHHA1 KKPNOBBG_02577 33035.JPJF01000015_gene4941 0.0 934.0 COG0642@1|root,COG2205@2|Bacteria,1V2VP@1239|Firmicutes,25E8Z@186801|Clostridia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_02578 33035.JPJF01000015_gene4942 3e-157 442.0 COG0745@1|root,COG0745@2|Bacteria,1TRS2@1239|Firmicutes,24AF1@186801|Clostridia 186801|Clostridia T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02579 33035.JPJF01000015_gene4943 4.33e-57 177.0 COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,3Y0A3@572511|Blautia 186801|Clostridia J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 KKPNOBBG_02580 33035.JPJF01000015_gene4944 7.09e-100 290.0 COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,3XZWB@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB KKPNOBBG_02581 33035.JPJF01000015_gene4945 1.01e-61 189.0 COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,3Y068@572511|Blautia 186801|Clostridia J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 KKPNOBBG_02582 33035.JPJF01000015_gene4946 1.53e-39 130.0 COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia,3Y0KE@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - DUF951 KKPNOBBG_02583 33035.JPJF01000015_gene4947 1.96e-166 466.0 COG0846@1|root,COG0846@2|Bacteria,1TQKD@1239|Firmicutes,2491J@186801|Clostridia,3XZIR@572511|Blautia 186801|Clostridia K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 KKPNOBBG_02584 33035.JPJF01000015_gene4948 1.76e-171 481.0 COG4509@1|root,COG4509@2|Bacteria,1V2FT@1239|Firmicutes,24GN2@186801|Clostridia,3XZ9S@572511|Blautia 186801|Clostridia S Sortase family srtB - 3.4.22.70 ko:K08600 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase KKPNOBBG_02585 33035.JPJF01000015_gene4949 3.08e-211 593.0 2BBU1@1|root,325CB@2|Bacteria,1V80P@1239|Firmicutes,24IWW@186801|Clostridia,3Y0VX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02587 33035.JPJF01000015_gene4950 0.0 1620.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia,3XZIP@572511|Blautia 186801|Clostridia G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_02588 33035.JPJF01000015_gene4952 1.12e-215 596.0 COG2207@1|root,COG2207@2|Bacteria,1U657@1239|Firmicutes,247V5@186801|Clostridia,3XZWM@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_02589 33035.JPJF01000015_gene4953 0.0 1119.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3XYJJ@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 - - 3.2.1.1,3.2.1.10 ko:K01176,ko:K01182 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00801,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C KKPNOBBG_02590 33035.JPJF01000015_gene4954 0.0 1016.0 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,3XYYI@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 malQ_1 - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 KKPNOBBG_02591 33035.JPJF01000015_gene4955 1.24e-132 377.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,3XZYR@572511|Blautia 186801|Clostridia S Maltose acetyltransferase - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_02592 33035.JPJF01000015_gene4958 1.75e-165 466.0 COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,25CIK@186801|Clostridia 186801|Clostridia S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos KKPNOBBG_02593 33035.JPJF01000015_gene4959 8.06e-236 650.0 COG0275@1|root,COG0275@2|Bacteria,1TP5R@1239|Firmicutes,248PH@186801|Clostridia,3XZ5Z@572511|Blautia 186801|Clostridia H Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH2 - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 KKPNOBBG_02594 33035.JPJF01000015_gene4960 1.7e-242 668.0 COG0673@1|root,COG0673@2|Bacteria,1UGN1@1239|Firmicutes,249ZU@186801|Clostridia,3Y1K5@572511|Blautia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_02595 33035.JPJF01000015_gene4961 7.47e-88 258.0 COG0346@1|root,COG0346@2|Bacteria,1V7XP@1239|Firmicutes,24KYI@186801|Clostridia,3Y0HK@572511|Blautia 186801|Clostridia E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_4 KKPNOBBG_02596 33035.JPJF01000015_gene4962 4.67e-158 448.0 COG5464@1|root,COG5464@2|Bacteria,1V394@1239|Firmicutes,24GXK@186801|Clostridia,3Y2CV@572511|Blautia 186801|Clostridia S PD-(D/E)XK nuclease family transposase - - - - - - - - - - - - PDDEXK_2 KKPNOBBG_02597 1437610.BREU_2246 6.91e-284 783.0 COG1621@1|root,COG1621@2|Bacteria,2H3S0@201174|Actinobacteria,4D05M@85004|Bifidobacteriales 201174|Actinobacteria G Glycosyl hydrolases family 32 - - 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 - GH32 - Glyco_hydro_32C,Glyco_hydro_32N KKPNOBBG_02598 1121115.AXVN01000108_gene626 5.75e-132 382.0 COG0395@1|root,COG0395@2|Bacteria,1UXJD@1239|Firmicutes,25M52@186801|Clostridia,3Y1KD@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_02599 742733.HMPREF9469_05466 1.06e-150 430.0 COG1175@1|root,COG1175@2|Bacteria,1TRI2@1239|Firmicutes,24DZ7@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_02600 592026.GCWU0000282_002968 2.06e-174 503.0 COG1653@1|root,COG1653@2|Bacteria,1UYBV@1239|Firmicutes,24E6F@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_02601 1121115.AXVN01000108_gene623 6.83e-127 388.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,25B1H@186801|Clostridia,3Y2A1@572511|Blautia 186801|Clostridia KT Helix-turn-helix domain - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_02602 592026.GCWU0000282_002970 2.65e-150 453.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,24ET6@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase KKPNOBBG_02603 33035.JPJF01000015_gene4964 0.0 1657.0 COG0457@1|root,COG3629@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,1VA4B@1239|Firmicutes,24P3V@186801|Clostridia 186801|Clostridia T Tetratricopeptide repeats - - - - - - - - - - - - TPR_2 KKPNOBBG_02604 33035.JPJF01000015_gene4965 0.0 973.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia 186801|Clostridia E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic KKPNOBBG_02605 33035.JPJF01000015_gene4966 9.03e-283 777.0 COG3314@1|root,COG3314@2|Bacteria,1TR35@1239|Firmicutes,249N2@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - Gate KKPNOBBG_02606 33035.JPJF01000015_gene4967 0.0 1272.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ6J@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - 1.3.1.31 ko:K10797 ko00360,ko01120,map00360,map01120 - R02252 RC00669 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_02607 33035.JPJF01000015_gene4968 0.0 1271.0 COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3Y156@572511|Blautia 186801|Clostridia E Urocanase C-terminal domain - - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N KKPNOBBG_02608 33035.JPJF01000015_gene4969 2.64e-46 150.0 COG3743@1|root,COG3743@2|Bacteria,1VEZU@1239|Firmicutes,24RST@186801|Clostridia 186801|Clostridia S tfoX C-terminal domain - - - ko:K07343 - - - - ko00000 - - - TfoX_C KKPNOBBG_02609 33035.JPJF01000015_gene4970 8.78e-57 178.0 COG0221@1|root,COG0221@2|Bacteria,1VB6Q@1239|Firmicutes,24NZI@186801|Clostridia 186801|Clostridia C Inorganic pyrophosphatase - - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - NUDIX,Pyrophosphatase KKPNOBBG_02610 33035.JPJF01000015_gene4971 2.21e-95 281.0 COG0406@1|root,COG0406@2|Bacteria,1V8SK@1239|Firmicutes,24KJ4@186801|Clostridia 186801|Clostridia G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 KKPNOBBG_02611 742740.HMPREF9474_01560 1.24e-176 504.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,2206M@1506553|Lachnoclostridium 186801|Clostridia S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_02612 742740.HMPREF9474_01559 1.75e-238 667.0 COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222GZ@1506553|Lachnoclostridium 186801|Clostridia S Short chain fatty acid transporter - - - - - - - - - - - - DcuC KKPNOBBG_02613 742740.HMPREF9474_01942 7.86e-136 407.0 COG4565@1|root,COG4565@2|Bacteria,1V2PC@1239|Firmicutes,24GSU@186801|Clostridia,22413@1506553|Lachnoclostridium 186801|Clostridia KT transcriptional regulatory protein - - - - - - - - - - - - - KKPNOBBG_02614 428126.CLOSPI_01773 6.44e-23 98.6 COG4974@1|root,COG4974@2|Bacteria,1UXHR@1239|Firmicutes,3VTGN@526524|Erysipelotrichia 526524|Erysipelotrichia L Phage integrase SAM-like domain - - - - - - - - - - - - Phage_int_SAM_1,Phage_integrase KKPNOBBG_02615 158189.SpiBuddy_0386 9.74e-08 53.1 COG1209@1|root,COG1209@2|Bacteria,2J5YM@203691|Spirochaetes 203691|Spirochaetes H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase KKPNOBBG_02616 657322.FPR_02690 2.11e-112 327.0 COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia,3WJE6@541000|Ruminococcaceae 186801|Clostridia G SIS domain gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 KKPNOBBG_02617 1384066.JAGT01000001_gene2780 1.9e-231 646.0 COG0241@1|root,COG1208@1|root,COG0241@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,3WGIE@541000|Ruminococcaceae 186801|Clostridia GJM phosphoglucomutase phosphomannomutase alpha beta alpha domain I gmhB - 2.7.7.13,2.7.7.71,3.1.3.82,3.1.3.83,5.4.2.8 ko:K00966,ko:K03273,ko:K15669,ko:K16881 ko00051,ko00520,ko00540,ko01100,ko01110,ko01130,map00051,map00520,map00540,map01100,map01110,map01130 M00064,M00114,M00361,M00362 R00885,R01818,R05647,R09771,R09772 RC00002,RC00017,RC00408 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hydrolase_like,NTP_transferase,PGM_PMM_I,PNK3P KKPNOBBG_02618 1286106.MPL1_00135 2.83e-06 47.4 COG1045@1|root,COG1045@2|Bacteria 2|Bacteria E serine acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep KKPNOBBG_02619 556261.HMPREF0240_00217 6.48e-207 576.0 COG2605@1|root,COG2605@2|Bacteria,1VU5A@1239|Firmicutes,24BK8@186801|Clostridia,36HT9@31979|Clostridiaceae 186801|Clostridia S GHMP kinases C terminal - - 2.7.1.168 ko:K07031 ko00540,map00540 - R09770 RC00002,RC00078 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N KKPNOBBG_02620 1280694.AUJQ01000003_gene1491 1.83e-121 371.0 COG2244@1|root,COG2244@2|Bacteria,1TP7R@1239|Firmicutes,24AD0@186801|Clostridia,3NHH2@46205|Pseudobutyrivibrio 186801|Clostridia Q Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C KKPNOBBG_02622 1121091.AUMP01000022_gene3771 2.74e-190 542.0 COG3754@1|root,COG3754@2|Bacteria,1UIQ8@1239|Firmicutes,4ISPX@91061|Bacilli 91061|Bacilli M Glycosyltransferase WbsX - - - - - - - - - - - - Glyco_tran_WbsX KKPNOBBG_02623 1121091.AUMP01000022_gene3769 5.19e-57 197.0 COG0438@1|root,COG0438@2|Bacteria,1VFZT@1239|Firmicutes,4HR14@91061|Bacilli 91061|Bacilli M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_02624 1123288.SOV_1c02450 3.34e-100 303.0 COG5017@1|root,COG5017@2|Bacteria,1V2RT@1239|Firmicutes 1239|Firmicutes M D-glucuronyl C5-epimerase C-terminus - - - - - - - - - - - - C5-epim_C KKPNOBBG_02625 411469.EUBHAL_01153 1.03e-54 184.0 COG0438@1|root,COG0438@2|Bacteria,1UYM0@1239|Firmicutes,24C85@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 KKPNOBBG_02626 469616.FMAG_02236 3.78e-109 329.0 COG0438@1|root,COG0438@2|Bacteria,37B6V@32066|Fusobacteria 32066|Fusobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 KKPNOBBG_02627 203119.Cthe_2341 1.2e-154 448.0 COG1215@1|root,COG1215@2|Bacteria,1TPY9@1239|Firmicutes,24E2E@186801|Clostridia,3WNSX@541000|Ruminococcaceae 186801|Clostridia M Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_02628 1280686.AUKE01000001_gene2134 1.34e-83 254.0 COG0546@1|root,COG0546@2|Bacteria,1UKM3@1239|Firmicutes,25FZV@186801|Clostridia 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 KKPNOBBG_02629 471875.RUMLAC_01831 7.73e-176 496.0 COG2232@1|root,COG2232@2|Bacteria,1TPT6@1239|Firmicutes,24DWY@186801|Clostridia,3WJW4@541000|Ruminococcaceae 186801|Clostridia S ATP-grasp domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3,HAD_2 KKPNOBBG_02630 658088.HMPREF0987_00046 1.86e-65 206.0 COG0110@1|root,COG0110@2|Bacteria,1V8CV@1239|Firmicutes,24GND@186801|Clostridia,27TAY@186928|unclassified Lachnospiraceae 186801|Clostridia S Bacterial transferase hexapeptide (six repeats) - - - ko:K19429 - - - - ko00000,ko01000 - - - Hexapep KKPNOBBG_02631 1078085.HMPREF1210_00719 1.82e-97 289.0 COG2120@1|root,COG2120@2|Bacteria,1UZDV@1239|Firmicutes,4HE79@91061|Bacilli,26HFB@186818|Planococcaceae 91061|Bacilli S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L KKPNOBBG_02632 1078085.HMPREF1210_00718 1.72e-138 400.0 COG0223@1|root,COG0223@2|Bacteria,1UZH4@1239|Firmicutes,4HF0N@91061|Bacilli 91061|Bacilli J Formyl transferase - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N KKPNOBBG_02633 1078085.HMPREF1210_00717 3.43e-81 248.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HCBG@91061|Bacilli,26FD5@186818|Planococcaceae 91061|Bacilli M COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - ko:K13012,ko:K19428 - - - - ko00000,ko01000,ko01005 - - - Bac_transf KKPNOBBG_02634 435591.BDI_0427 8.27e-255 704.0 COG0399@1|root,COG0399@2|Bacteria,4NFAI@976|Bacteroidetes,2FN8X@200643|Bacteroidia,22XBZ@171551|Porphyromonadaceae 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 KKPNOBBG_02635 33035.JPJF01000042_gene362 2.19e-188 543.0 COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,3XYZJ@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score capD - - - - - - - - - - - CoA_binding_3,Polysacc_synt_2 KKPNOBBG_02636 33035.JPJF01000110_gene5203 0.0 1831.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C KKPNOBBG_02637 33035.JPJF01000110_gene5204 9.52e-128 364.0 COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,24P8J@186801|Clostridia,3Y1PF@572511|Blautia 186801|Clostridia S HutD - - - - - - - - - - - - HutD KKPNOBBG_02638 33035.JPJF01000110_gene5205 5.75e-64 196.0 2ED91@1|root,3375H@2|Bacteria,1VFTX@1239|Firmicutes,24RJH@186801|Clostridia,3Y1TN@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02639 742740.HMPREF9474_01501 0.0 931.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,21Z3Y@1506553|Lachnoclostridium 186801|Clostridia M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K05020 - - - - ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 - - BCCT KKPNOBBG_02640 33035.JPJF01000102_gene3423 0.0 957.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,24A4G@186801|Clostridia 186801|Clostridia E Aromatic amino acid lyase - - - - - - - - - - - - Lyase_aromatic KKPNOBBG_02641 33035.JPJF01000102_gene3422 0.0 1396.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia 186801|Clostridia C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 KKPNOBBG_02642 33035.JPJF01000102_gene3421 1.18e-177 498.0 COG1319@1|root,COG1319@2|Bacteria,1V3PV@1239|Firmicutes,24HB7@186801|Clostridia 186801|Clostridia C FAD binding domain in molybdopterin dehydrogenase - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 KKPNOBBG_02643 33035.JPJF01000102_gene3420 5.57e-108 311.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,3Y2B4@572511|Blautia 186801|Clostridia C [2Fe-2S] binding domain cutS - 1.17.1.5,1.2.5.3 ko:K03518,ko:K20446 ko00760,ko01120,map00760,map01120 - R01720,R11168 RC00589,RC02800 ko00000,ko00001,ko01000 - - - Fer2,Fer2_2 KKPNOBBG_02644 33035.JPJF01000102_gene3419 8.68e-219 607.0 COG3053@1|root,COG3053@2|Bacteria,1TSGQ@1239|Firmicutes,248Y4@186801|Clostridia,3Y12J@572511|Blautia 186801|Clostridia C Citrate lyase ligase C-terminal domain citC - 6.2.1.22 ko:K01910 ko02020,map02020 - R04449 RC00012,RC00039 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Acetyltransf_10,Citrate_ly_lig KKPNOBBG_02645 33035.JPJF01000102_gene3418 8.56e-298 818.0 COG1767@1|root,COG3697@1|root,COG1767@2|Bacteria,COG3697@2|Bacteria,1TQGQ@1239|Firmicutes,24BQH@186801|Clostridia,3Y13R@572511|Blautia 186801|Clostridia HI ATP:dephospho-CoA triphosphoribosyl transferase citG - 2.4.2.52,2.7.7.61 ko:K05966,ko:K13927 ko02020,map02020 - R09675,R10706 RC00049,RC00063 ko00000,ko00001,ko01000 - - - CitG,CitX KKPNOBBG_02646 33035.JPJF01000102_gene3417 8.61e-102 296.0 COG0454@1|root,COG0456@2|Bacteria,1VGZX@1239|Firmicutes,24I40@186801|Clostridia,3Y0HB@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_02647 33035.JPJF01000102_gene3415 8.56e-150 424.0 COG4912@1|root,COG4912@2|Bacteria,1TSAW@1239|Firmicutes,24GX4@186801|Clostridia 186801|Clostridia L DNA alkylation repair enzyme - - - - - - - - - - - - DNA_alkylation KKPNOBBG_02648 33035.JPJF01000102_gene3414 3.61e-114 329.0 COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia,3Y0B0@572511|Blautia 186801|Clostridia M Acetyltransferase (GNAT) domain pat - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 KKPNOBBG_02650 33035.JPJF01000102_gene3413 3.92e-138 393.0 COG0613@1|root,COG0613@2|Bacteria,1V33M@1239|Firmicutes,24H1U@186801|Clostridia 186801|Clostridia S PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP,PHP_C KKPNOBBG_02651 33035.JPJF01000102_gene3412 1.4e-234 654.0 29WCX@1|root,30HYK@2|Bacteria,1UDXU@1239|Firmicutes,25IS5@186801|Clostridia,3Y24Z@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02652 33035.JPJF01000102_gene3411 3.04e-161 456.0 28I08@1|root,2ZBVK@2|Bacteria,1V2VU@1239|Firmicutes,25DBA@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02653 33035.JPJF01000102_gene3410 1.2e-105 307.0 2B4B6@1|root,30XHG@2|Bacteria,1V4KI@1239|Firmicutes,25D1M@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02654 553973.CLOHYLEM_07139 0.0 924.0 COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,21YHB@1506553|Lachnoclostridium 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_02655 553973.CLOHYLEM_07140 2.13e-118 343.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,21Z5W@1506553|Lachnoclostridium 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02656 553973.CLOHYLEM_07142 1.28e-81 248.0 COG1309@1|root,COG1309@2|Bacteria,1VGTE@1239|Firmicutes,24Q9W@186801|Clostridia,21ZVM@1506553|Lachnoclostridium 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_02657 33035.JPJF01000102_gene3409 2.01e-247 678.0 COG0407@1|root,COG0407@2|Bacteria,1V7V8@1239|Firmicutes,24M1I@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D KKPNOBBG_02658 33035.JPJF01000102_gene3408 0.0 904.0 COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes 1239|Firmicutes QT COG2508 Regulator of polyketide synthase expression - - - - - - - - - - - - HTH_30 KKPNOBBG_02659 33035.JPJF01000102_gene3407 3.35e-111 322.0 COG1670@1|root,COG1670@2|Bacteria,1V2EM@1239|Firmicutes,24GSX@186801|Clostridia 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 KKPNOBBG_02660 33035.JPJF01000102_gene3405 1.44e-88 265.0 29UTS@1|root,30G67@2|Bacteria,1V4QI@1239|Firmicutes,24G9Z@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02661 318464.IO99_06650 2.71e-96 289.0 COG3393@1|root,COG3393@2|Bacteria,1TRN7@1239|Firmicutes,24A2B@186801|Clostridia,36HV9@31979|Clostridiaceae 186801|Clostridia S GNAT acetyltransferase - - - - - - - - - - - - Acetyltransf_1,GNAT_acetyltran KKPNOBBG_02662 1410617.JHXH01000017_gene1122 1.77e-29 109.0 COG0454@1|root,COG0456@2|Bacteria,1VRI3@1239|Firmicutes,25H3M@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_02664 33035.JPJF01000102_gene3402 2.81e-84 249.0 2CEH6@1|root,32RZW@2|Bacteria,1UGH5@1239|Firmicutes,24KBE@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - Polyketide_cyc2 KKPNOBBG_02665 33035.JPJF01000102_gene3401 0.0 880.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3XYNQ@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Na_H_antiporter KKPNOBBG_02666 33035.JPJF01000102_gene3400 1.27e-226 625.0 COG2515@1|root,COG2515@2|Bacteria,1V07K@1239|Firmicutes,258XR@186801|Clostridia,3Y21E@572511|Blautia 186801|Clostridia E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP KKPNOBBG_02667 33035.JPJF01000102_gene3399 3.75e-77 230.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,3Y05K@572511|Blautia 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP KKPNOBBG_02668 33035.JPJF01000102_gene3398 1.28e-147 416.0 COG2964@1|root,COG2964@2|Bacteria,1V33R@1239|Firmicutes,25CHI@186801|Clostridia,3Y1I2@572511|Blautia 186801|Clostridia S YheO-like PAS domain - - - - - - - - - - - - HTH_22,PAS_6 KKPNOBBG_02669 556261.HMPREF0240_03526 1.74e-91 275.0 28N4D@1|root,2ZB9V@2|Bacteria,1UPRR@1239|Firmicutes,24MJV@186801|Clostridia,36S3K@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02670 556261.HMPREF0240_03525 2.03e-93 281.0 arCOG13338@1|root,32UAU@2|Bacteria,1VBA1@1239|Firmicutes,24P3H@186801|Clostridia,36MUA@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF5058) - - - - - - - - - - - - DUF5058 KKPNOBBG_02671 1230342.CTM_23689 9.17e-222 625.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,36EX4@31979|Clostridiaceae 186801|Clostridia S amidohydrolase abgB - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 KKPNOBBG_02672 911239.CF149_13190 5.82e-136 409.0 COG2843@1|root,COG2843@2|Bacteria,1N8I2@1224|Proteobacteria,1SEGB@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap KKPNOBBG_02673 1158612.I580_02404 3.06e-86 296.0 COG3664@1|root,COG4977@1|root,COG3664@2|Bacteria,COG4977@2|Bacteria,1TQGI@1239|Firmicutes,4I6Q0@91061|Bacilli,4B1FD@81852|Enterococcaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - Glyco_hydro_39,HTH_18 KKPNOBBG_02674 33035.JPJF01000102_gene3397 4.79e-196 545.0 COG4399@1|root,COG4399@2|Bacteria,1TQDH@1239|Firmicutes,24K94@186801|Clostridia,3Y1DQ@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 KKPNOBBG_02675 33035.JPJF01000102_gene3396 1.38e-291 798.0 COG3681@1|root,COG3681@2|Bacteria,1TQF5@1239|Firmicutes,2488Q@186801|Clostridia,3XYV4@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score - - - - - - - - - - - - SDH_alpha KKPNOBBG_02676 33035.JPJF01000102_gene3395 9.16e-105 305.0 2DQ8Z@1|root,335CG@2|Bacteria,1V9R5@1239|Firmicutes,24I50@186801|Clostridia,3Y02P@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_02677 537007.BLAHAN_05046 8.04e-121 348.0 COG0484@1|root,COG0484@2|Bacteria,1V1GK@1239|Firmicutes,2494E@186801|Clostridia,3XZYJ@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,TPR_2 KKPNOBBG_02678 33035.JPJF01000029_gene2102 9.01e-196 544.0 2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,3XZ5E@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02679 33035.JPJF01000029_gene2103 1.35e-156 440.0 COG2357@1|root,COG2357@2|Bacteria,1TQ2F@1239|Firmicutes,249FE@186801|Clostridia,3XZ07@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT KKPNOBBG_02680 33035.JPJF01000029_gene2104 9.04e-137 388.0 29WCQ@1|root,30HYD@2|Bacteria,1TXD7@1239|Firmicutes,25JJX@186801|Clostridia,3Y1HX@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02681 33035.JPJF01000029_gene2105 3.81e-294 806.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3Y0XB@572511|Blautia 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_02682 33035.JPJF01000029_gene2106 9.33e-178 496.0 COG0860@1|root,COG0860@2|Bacteria,1TS91@1239|Firmicutes,25B1N@186801|Clostridia,3XZHM@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 cwlC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,SPOR KKPNOBBG_02683 33035.JPJF01000029_gene2107 3.55e-109 314.0 COG1803@1|root,COG1803@2|Bacteria,1V58X@1239|Firmicutes,24J2X@186801|Clostridia,3Y2C5@572511|Blautia 186801|Clostridia G MGS-like domain - - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS KKPNOBBG_02684 33035.JPJF01000029_gene2108 6.33e-209 579.0 COG1597@1|root,COG1597@2|Bacteria,1TQJH@1239|Firmicutes,24BHT@186801|Clostridia,3XZTC@572511|Blautia 186801|Clostridia I COG COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase ytlR - - - - - - - - - - - DAGK_cat KKPNOBBG_02685 33035.JPJF01000029_gene2109 2.27e-125 362.0 COG0584@1|root,COG0584@2|Bacteria,1V1PF@1239|Firmicutes,24EG1@186801|Clostridia,3Y04X@572511|Blautia 186801|Clostridia C Glycerophosphoryl diester phosphodiesterase family - - - - - - - - - - - - GDPD KKPNOBBG_02686 33035.JPJF01000029_gene2110 6.7e-148 417.0 COG0671@1|root,COG0671@2|Bacteria,1V2ZH@1239|Firmicutes,24HRY@186801|Clostridia,3Y0B6@572511|Blautia 186801|Clostridia I Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - PAP2,PAP2_3 KKPNOBBG_02687 33035.JPJF01000029_gene2111 7.05e-232 639.0 COG0463@1|root,COG0463@2|Bacteria,1TT6C@1239|Firmicutes,248F2@186801|Clostridia,3XYRU@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 kfoC_2 - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_02688 33035.JPJF01000029_gene2112 1.04e-227 630.0 COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,25E4K@186801|Clostridia,3XZJ1@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4,SfsA KKPNOBBG_02689 33035.JPJF01000029_gene2113 1.37e-150 424.0 COG1489@1|root,COG1489@2|Bacteria,1VTYF@1239|Firmicutes,25E56@186801|Clostridia,3XZS7@572511|Blautia 186801|Clostridia S Sugar fermentation stimulation protein sfsA - - ko:K06206 - - - - ko00000 - - - SfsA KKPNOBBG_02690 33035.JPJF01000029_gene2114 2.91e-189 526.0 COG0647@1|root,COG0647@2|Bacteria,1TQGM@1239|Firmicutes,24B6W@186801|Clostridia,3Y1BJ@572511|Blautia 186801|Clostridia G Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - Hydrolase_6,Hydrolase_like,NUDIX KKPNOBBG_02691 33035.JPJF01000029_gene2115 6.45e-73 219.0 COG3862@1|root,COG3862@2|Bacteria,1VA4U@1239|Firmicutes,24MN9@186801|Clostridia,3Y0DY@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF1667) - - - - - - - - - - - - DUF1667 KKPNOBBG_02692 33035.JPJF01000029_gene2116 1.28e-292 800.0 COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,3XYIW@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_3 KKPNOBBG_02693 33035.JPJF01000029_gene2117 0.0 885.0 COG0579@1|root,COG0579@2|Bacteria,1TRDH@1239|Firmicutes,248IK@186801|Clostridia,3XZGX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 lhgO - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,Fer2_BFD KKPNOBBG_02694 33035.JPJF01000029_gene2118 2.22e-120 345.0 COG1954@1|root,COG1954@2|Bacteria,1V4IE@1239|Firmicutes,24HDM@186801|Clostridia,3Y03V@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 glpP - - ko:K02443 - - - - ko00000,ko03000 - - - G3P_antiterm KKPNOBBG_02695 33035.JPJF01000029_gene2119 0.0 971.0 COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,3XYNG@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - PG_binding_4,YkuD KKPNOBBG_02696 33035.JPJF01000029_gene2120 4.35e-23 88.2 2BB2A@1|root,324IE@2|Bacteria,1UQTB@1239|Firmicutes,24UV2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02697 33035.JPJF01000029_gene2121 7.88e-34 116.0 2EHYT@1|root,33BQ9@2|Bacteria,1VM0T@1239|Firmicutes,24TTI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02698 33035.JPJF01000029_gene2122 1.45e-210 583.0 COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia 186801|Clostridia M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 KKPNOBBG_02699 996306.SSUR61_0249 1.41e-26 98.6 COG3655@1|root,COG3655@2|Bacteria,1U9A3@1239|Firmicutes,4IJCS@91061|Bacilli,1WU3T@1307|Streptococcus suis 91061|Bacilli K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 KKPNOBBG_02701 33035.JPJF01000029_gene2124 2.61e-315 859.0 COG0771@1|root,COG0771@2|Bacteria,1UHPI@1239|Firmicutes,25E9J@186801|Clostridia,3XZ9H@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 murE2 - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - DUF1727,Mur_ligase_M KKPNOBBG_02702 33035.JPJF01000029_gene2125 8.37e-172 479.0 COG3442@1|root,COG3442@2|Bacteria,1U7I9@1239|Firmicutes,24A80@186801|Clostridia,3XZ8X@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07009 - - - - ko00000 - - - GATase_3 KKPNOBBG_02703 33035.JPJF01000029_gene2126 1.45e-298 817.0 COG4565@1|root,COG4565@2|Bacteria,1V2PC@1239|Firmicutes,24GSU@186801|Clostridia 186801|Clostridia KT transcriptional regulatory protein - - - - - - - - - - - - - KKPNOBBG_02704 33035.JPJF01000029_gene2127 2.58e-298 819.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,3XZGT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_02705 33035.JPJF01000029_gene2128 6.16e-310 847.0 COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia 186801|Clostridia S C4-dicarboxylate anaerobic carrier - - - - - - - - - - - - DcuC KKPNOBBG_02706 33035.JPJF01000120_gene1806 3.87e-37 125.0 2FA0G@1|root,3429J@2|Bacteria,1VXK8@1239|Firmicutes,24RRN@186801|Clostridia,3Y0WK@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02707 33035.JPJF01000120_gene1807 1.04e-30 109.0 2EDTM@1|root,30GQ5@2|Bacteria,1UGEW@1239|Firmicutes,25NV2@186801|Clostridia,3Y22M@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4177) - - - - - - - - - - - - DUF4177 KKPNOBBG_02709 33035.JPJF01000120_gene1808 5.84e-92 274.0 COG1309@1|root,COG1309@2|Bacteria,1V3XC@1239|Firmicutes,24JC2@186801|Clostridia 186801|Clostridia K transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N KKPNOBBG_02710 33035.JPJF01000120_gene1809 9e-136 387.0 COG0739@1|root,COG0739@2|Bacteria,1UYKB@1239|Firmicutes,25B2K@186801|Clostridia 186801|Clostridia M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 KKPNOBBG_02713 33035.JPJF01000038_gene495 0.0 1230.0 COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,3XYRR@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 cooS - 1.2.7.4 ko:K00198 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 M00377 R07157,R08034 RC00250,RC02800 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS04490 Prismane KKPNOBBG_02714 33035.JPJF01000038_gene494 5.12e-96 280.0 COG1142@1|root,COG1142@2|Bacteria,1V809@1239|Firmicutes,25E9V@186801|Clostridia,3Y27V@572511|Blautia 186801|Clostridia C carbon monoxide dehydrogenase, iron sulfur subunit K00196 - - - ko:K00196 ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200 - R07157,R08034 RC00250,RC02800 ko00000,ko00001 - - - Fer4_11,Fer4_4 KKPNOBBG_02715 33035.JPJF01000038_gene493 7.29e-269 739.0 COG1251@1|root,COG1251@2|Bacteria,1UKQX@1239|Firmicutes,25E9F@186801|Clostridia,3XZM4@572511|Blautia 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase narC - - - - - - - - - - - Pyr_redox_2 KKPNOBBG_02716 33035.JPJF01000038_gene492 1.33e-293 801.0 COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3XYHR@572511|Blautia 186801|Clostridia J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b KKPNOBBG_02717 33035.JPJF01000038_gene491 1.56e-211 596.0 29U5C@1|root,30FEZ@2|Bacteria,1UDYI@1239|Firmicutes,25ISV@186801|Clostridia,3Y263@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02718 33035.JPJF01000038_gene489 0.0 927.0 COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,3XZB8@572511|Blautia 186801|Clostridia EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind KKPNOBBG_02719 33035.JPJF01000038_gene488 0.0 1002.0 COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,3XZ38@572511|Blautia 186801|Clostridia E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 KKPNOBBG_02720 33035.JPJF01000038_gene487 7.79e-169 474.0 COG0134@1|root,COG0134@2|Bacteria,1TR94@1239|Firmicutes,249ZY@186801|Clostridia,3XYU5@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 trpC - 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS KKPNOBBG_02721 33035.JPJF01000038_gene486 4.47e-118 341.0 COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,3Y006@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI KKPNOBBG_02722 33035.JPJF01000038_gene485 3.56e-280 766.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,3XYNP@572511|Blautia 186801|Clostridia E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_02723 33035.JPJF01000038_gene484 2.46e-174 487.0 COG0159@1|root,COG0159@2|Bacteria,1TPXA@1239|Firmicutes,248M2@186801|Clostridia,3XYZ4@572511|Blautia 186801|Clostridia E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA KKPNOBBG_02724 33035.JPJF01000038_gene483 0.0 903.0 COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,3XZR6@572511|Blautia 186801|Clostridia I Acetyl-CoA carboxylase alpha subunit - - - - - - - - - - - - Carboxyl_trans KKPNOBBG_02725 33035.JPJF01000038_gene482 2.1e-152 431.0 2DNAY@1|root,32WHQ@2|Bacteria,1VDJJ@1239|Firmicutes,24R0U@186801|Clostridia,3Y289@572511|Blautia 186801|Clostridia P Oxaloacetate decarboxylase, gamma chain - - - - - - - - - - - - OAD_gamma KKPNOBBG_02726 537007.BLAHAN_04888 5.62e-40 136.0 COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,3Y06B@572511|Blautia 186801|Clostridia I Biotin-requiring enzyme gcdC - - - - - - - - - - - Biotin_lipoyl KKPNOBBG_02727 33035.JPJF01000038_gene480 3.67e-257 707.0 COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia,3XZ7I@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 10.00 gcdB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta KKPNOBBG_02728 33035.JPJF01000038_gene479 0.0 917.0 COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,3XZ83@572511|Blautia 186801|Clostridia C Pyruvate carboxylase, C-terminal domain subunit oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA KKPNOBBG_02730 33035.JPJF01000038_gene478 5.1e-211 584.0 COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,3XZ7C@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_6,SIS KKPNOBBG_02731 33035.JPJF01000038_gene477 1.55e-274 753.0 COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,3XYPF@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07007 - - - - ko00000 - - - HI0933_like KKPNOBBG_02732 33035.JPJF01000038_gene476 1.64e-135 386.0 COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,3XZMG@572511|Blautia 186801|Clostridia F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin KKPNOBBG_02733 33035.JPJF01000038_gene475 3.01e-191 532.0 COG0761@1|root,COG0761@2|Bacteria,1UHT7@1239|Firmicutes,25E67@186801|Clostridia,3XYNX@572511|Blautia 186801|Clostridia C Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB KKPNOBBG_02734 33035.JPJF01000038_gene474 7.05e-249 684.0 COG0539@1|root,COG0539@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3XZ91@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 ispH - 1.17.7.4 ko:K02945,ko:K03527 ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010 M00096,M00178 R05884,R08210 RC01137,RC01487 br01610,ko00000,ko00001,ko00002,ko01000,ko03011 - - - LYTB,S1 KKPNOBBG_02735 33035.JPJF01000038_gene473 4.03e-231 640.0 COG3359@1|root,COG3359@2|Bacteria,1U725@1239|Firmicutes,24A9V@186801|Clostridia,3Y0A0@572511|Blautia 186801|Clostridia L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 KKPNOBBG_02736 33035.JPJF01000038_gene472 5.39e-191 533.0 COG4905@1|root,COG4905@2|Bacteria,1V2HX@1239|Firmicutes,24B3D@186801|Clostridia,3Y072@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC_trans_CmpB KKPNOBBG_02737 33035.JPJF01000038_gene471 5.57e-305 833.0 COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,3XYXE@572511|Blautia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB KKPNOBBG_02738 33035.JPJF01000038_gene470 9.05e-214 591.0 COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,3XYSH@572511|Blautia 186801|Clostridia C Electron transport complex rnfD - - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE KKPNOBBG_02739 33035.JPJF01000038_gene469 2.54e-121 348.0 COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,3XZTQ@572511|Blautia 186801|Clostridia P Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind KKPNOBBG_02740 33035.JPJF01000038_gene468 1.49e-157 442.0 COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,3XYKR@572511|Blautia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - iHN637.CLJU_RS05585 Rnf-Nqr KKPNOBBG_02741 33035.JPJF01000038_gene467 6.67e-123 352.0 COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,3XYQD@572511|Blautia 186801|Clostridia C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr KKPNOBBG_02742 33035.JPJF01000038_gene466 6.62e-164 461.0 COG2768@1|root,COG2878@1|root,COG2768@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,3XZFG@572511|Blautia 186801|Clostridia C F420-non-reducing hydrogenase rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4,Fer4_13,Fer4_4,Fer4_9 KKPNOBBG_02743 33035.JPJF01000038_gene465 1.42e-195 548.0 COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,3XZKQ@572511|Blautia 186801|Clostridia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE KKPNOBBG_02744 33035.JPJF01000038_gene464 5.3e-68 207.0 COG5341@1|root,COG5341@2|Bacteria,1VEPD@1239|Firmicutes,24QPH@186801|Clostridia,3Y0GM@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - NusG_II KKPNOBBG_02745 33035.JPJF01000038_gene463 7.22e-91 268.0 COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,3Y096@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - Hpre_diP_synt_I KKPNOBBG_02746 33035.JPJF01000038_gene462 4.13e-132 376.0 COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3XZX0@572511|Blautia 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N KKPNOBBG_02747 33035.JPJF01000038_gene461 4.86e-234 644.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,3XZK8@572511|Blautia 186801|Clostridia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N KKPNOBBG_02748 33035.JPJF01000038_gene460 1.07e-82 245.0 COG3027@1|root,COG3027@2|Bacteria,1V4E5@1239|Firmicutes,24HQR@186801|Clostridia,3Y0AS@572511|Blautia 186801|Clostridia D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA KKPNOBBG_02749 33035.JPJF01000038_gene459 0.0 1288.0 COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,3XYUZ@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - DUF3656,Peptidase_U32 KKPNOBBG_02750 33035.JPJF01000038_gene458 6.26e-293 804.0 COG0772@1|root,COG0772@2|Bacteria,1TQ82@1239|Firmicutes,248QS@186801|Clostridia,3XYN1@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score 10.00 ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FHA,FTSW_RODA_SPOVE KKPNOBBG_02751 33035.JPJF01000038_gene457 3.37e-303 831.0 COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia,3XYMX@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score pbpA2 - - ko:K05364 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01011 - - - Transpeptidase KKPNOBBG_02752 33035.JPJF01000038_gene456 8.49e-105 302.0 COG1051@1|root,COG1051@2|Bacteria,1V4E6@1239|Firmicutes,24HPT@186801|Clostridia,3XZUN@572511|Blautia 186801|Clostridia F Belongs to the Nudix hydrolase family apfA - - - - - - - - - - - NUDIX KKPNOBBG_02753 33035.JPJF01000038_gene455 0.0 961.0 COG2326@1|root,COG2326@2|Bacteria,1TQQR@1239|Firmicutes,249HE@186801|Clostridia,3XZ8V@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 pap - - - - - - - - - - - PPK2 KKPNOBBG_02754 33035.JPJF01000038_gene454 2.88e-69 209.0 2CSSR@1|root,2ZRRI@2|Bacteria,1W6GK@1239|Firmicutes,2540H@186801|Clostridia,3Y0MA@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02755 33035.JPJF01000038_gene453 2.46e-146 423.0 2E3Z2@1|root,32YW0@2|Bacteria,1VGF4@1239|Firmicutes,24PIY@186801|Clostridia,3Y0BT@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - DUF2953 KKPNOBBG_02756 33035.JPJF01000038_gene452 2.66e-70 214.0 COG3874@1|root,COG3874@2|Bacteria,1V99U@1239|Firmicutes,24K00@186801|Clostridia,3Y06K@572511|Blautia 186801|Clostridia S Sporulation protein YtfJ (Spore_YtfJ) - - - - - - - - - - - - Spore_YtfJ KKPNOBBG_02757 476272.RUMHYD_00500 2.1e-37 125.0 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,3Y0NA@572511|Blautia 186801|Clostridia J COG COG0227 Ribosomal protein L28 rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 KKPNOBBG_02758 33035.JPJF01000038_gene451 9.77e-73 219.0 COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia,3Y05W@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Asp23 KKPNOBBG_02759 33035.JPJF01000038_gene450 0.0 1015.0 COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,3XYY8@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 KKPNOBBG_02760 33035.JPJF01000038_gene449 0.0 1276.0 COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3XYJZ@572511|Blautia 186801|Clostridia L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge KKPNOBBG_02761 33035.JPJF01000038_gene448 0.0 1368.0 COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,3XYHV@572511|Blautia 186801|Clostridia V COG COG0577 ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_02762 33035.JPJF01000038_gene447 7.21e-41 140.0 2DRHG@1|root,33BRY@2|Bacteria,1VKXA@1239|Firmicutes,24UU3@186801|Clostridia,3Y0P6@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02763 33035.JPJF01000038_gene446 1.13e-39 132.0 2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia,3Y0GC@572511|Blautia 186801|Clostridia S COG NOG16862 non supervised orthologous group sasP - - ko:K06421 - - - - ko00000 - - - SASP KKPNOBBG_02764 33035.JPJF01000038_gene445 3.52e-92 269.0 COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,3Y038@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 mgsA - 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - - MGS KKPNOBBG_02765 33035.JPJF01000038_gene444 3.96e-126 359.0 COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,3XZUU@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 KKPNOBBG_02766 33035.JPJF01000038_gene443 3.22e-104 302.0 COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,3XZXZ@572511|Blautia 186801|Clostridia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like KKPNOBBG_02767 33035.JPJF01000038_gene442 2.98e-90 270.0 COG0711@1|root,COG0711@2|Bacteria,1V97P@1239|Firmicutes,24JGQ@186801|Clostridia,3XZBA@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02768 33035.JPJF01000038_gene441 5.93e-183 512.0 COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia,3Y01Q@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 ylbJ - - - - - - - - - - - Gate KKPNOBBG_02769 556261.HMPREF0240_01113 2.13e-49 165.0 COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes 1239|Firmicutes C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH_2 KKPNOBBG_02770 537007.BLAHAN_04287 2.21e-111 327.0 COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia,3XYUH@572511|Blautia 186801|Clostridia G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion nagB - 3.5.99.6 ko:K02564 ko00520,ko01100,map00520,map01100 - R00765 RC00163 ko00000,ko00001,ko01000 - - - Glucosamine_iso KKPNOBBG_02771 556261.HMPREF0240_01121 2.8e-286 785.0 COG0161@1|root,COG0161@2|Bacteria,1UM4K@1239|Firmicutes 1239|Firmicutes H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.105 ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R10699 RC00062,RC00887 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_3 KKPNOBBG_02772 476272.RUMHYD_03470 1.98e-165 475.0 COG1940@1|root,COG1940@2|Bacteria,1VQW7@1239|Firmicutes,24YU9@186801|Clostridia 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK KKPNOBBG_02773 476272.RUMHYD_03469 6.69e-164 465.0 COG1940@1|root,COG1940@2|Bacteria,1V1EQ@1239|Firmicutes,24FHR@186801|Clostridia 186801|Clostridia GK ROK family - - 2.7.1.55 ko:K00881 ko00051,ko01120,map00051,map01120 - R03576 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK KKPNOBBG_02774 1121335.Clst_2057 2.37e-11 60.8 COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia,3WKEN@541000|Ruminococcaceae 186801|Clostridia G PTS HPr component phosphorylation site - - - - - - - - - - - - PTS-HPr KKPNOBBG_02775 33035.JPJF01000037_gene2930 0.0 1162.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3XZ8U@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase KKPNOBBG_02776 33035.JPJF01000037_gene2945 7.17e-154 432.0 COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,3XYGI@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 yqfA - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII KKPNOBBG_02777 33035.JPJF01000037_gene2946 0.0 1493.0 COG0642@1|root,COG0642@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,3Y102@572511|Blautia 186801|Clostridia T Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - HATPase_c,HisKA,Response_reg,SBP_bac_3 KKPNOBBG_02778 33035.JPJF01000037_gene2947 0.0 1435.0 COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia 186801|Clostridia G hydrolase, family 65, central catalytic - - 2.4.1.64 ko:K05342 ko00500,ko01100,map00500,map01100 - R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m KKPNOBBG_02779 33035.JPJF01000037_gene2948 2.01e-131 375.0 COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia 186801|Clostridia S Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED pgmB - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_02780 33035.JPJF01000037_gene2949 1.03e-139 395.0 COG0110@1|root,COG0110@2|Bacteria,1TQQB@1239|Firmicutes,25B1T@186801|Clostridia,3Y2DW@572511|Blautia 186801|Clostridia S Maltose acetyltransferase - - 2.3.1.18 ko:K00633 - - - - ko00000,ko01000 - - - Hexapep,Mac KKPNOBBG_02782 33035.JPJF01000037_gene2951 1.04e-251 689.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_02783 33035.JPJF01000037_gene2952 0.0 902.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 KKPNOBBG_02784 33035.JPJF01000037_gene2953 0.0 926.0 COG2508@1|root,COG2508@2|Bacteria,1VIT3@1239|Firmicutes,24JXW@186801|Clostridia,3Y0T9@572511|Blautia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_02785 33035.JPJF01000037_gene2954 1.77e-135 385.0 COG5012@1|root,COG5012@2|Bacteria,1VSJU@1239|Firmicutes,24XK2@186801|Clostridia,3Y145@572511|Blautia 186801|Clostridia S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 KKPNOBBG_02786 33035.JPJF01000037_gene2955 1.12e-129 368.0 COG5423@1|root,COG5423@2|Bacteria,1V8Y4@1239|Firmicutes,24EAF@186801|Clostridia,3Y1BP@572511|Blautia 186801|Clostridia S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 KKPNOBBG_02787 33035.JPJF01000037_gene2956 0.0 1092.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,3Y14F@572511|Blautia 186801|Clostridia C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 KKPNOBBG_02788 33035.JPJF01000037_gene2957 0.0 1390.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,3XYN9@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase,PRK KKPNOBBG_02789 33035.JPJF01000037_gene2969 9.74e-138 390.0 COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,3Y0XR@572511|Blautia 186801|Clostridia S B12 binding domain - - - - - - - - - - - - B12-binding,B12-binding_2 KKPNOBBG_02790 33035.JPJF01000037_gene2970 6.56e-185 515.0 COG1410@1|root,COG1410@2|Bacteria,1UV7K@1239|Firmicutes,25CEH@186801|Clostridia,3Y0ZA@572511|Blautia 186801|Clostridia E Pterin binding enzyme - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind KKPNOBBG_02791 33035.JPJF01000037_gene2971 6.17e-229 632.0 COG1609@1|root,COG1609@2|Bacteria,1TS5M@1239|Firmicutes,24AWP@186801|Clostridia,3Y018@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_02792 33035.JPJF01000037_gene2972 5.52e-288 790.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,25MFS@186801|Clostridia,3Y1U2@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_02793 33035.JPJF01000037_gene2973 3.01e-228 636.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,3Y1I8@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10237 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - BPD_transp_1 KKPNOBBG_02794 33035.JPJF01000037_gene2974 2.1e-183 511.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia,3Y0HM@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02795 33035.JPJF01000037_gene2975 0.0 1092.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3XZ6T@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 - - 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C KKPNOBBG_02796 33035.JPJF01000037_gene2976 2.93e-171 482.0 COG5464@1|root,COG5464@2|Bacteria,1UZWF@1239|Firmicutes,25D0T@186801|Clostridia 186801|Clostridia S PD-(D/E)XK nuclease family transposase - - - - - - - - - - - - PDDEXK_2 KKPNOBBG_02797 33035.JPJF01000037_gene2977 8.06e-251 688.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_02798 33035.JPJF01000037_gene2978 8.01e-266 729.0 COG1940@1|root,COG1940@2|Bacteria,1UY4P@1239|Firmicutes,24E3X@186801|Clostridia 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK KKPNOBBG_02799 33035.JPJF01000037_gene2979 2.91e-268 736.0 COG1846@1|root,COG1940@1|root,COG1846@2|Bacteria,COG1940@2|Bacteria,1UY4P@1239|Firmicutes,24E3X@186801|Clostridia 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK KKPNOBBG_02800 33035.JPJF01000037_gene2980 1.37e-248 682.0 COG0673@1|root,COG0673@2|Bacteria,1TSCE@1239|Firmicutes,24BFP@186801|Clostridia 186801|Clostridia S Oxidoreductase NAD-binding domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_02801 33035.JPJF01000037_gene2981 2.51e-293 802.0 COG1653@1|root,COG1653@2|Bacteria,1VR2M@1239|Firmicutes,24YJT@186801|Clostridia,3Y1T3@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_02802 33035.JPJF01000037_gene2982 1.09e-199 554.0 COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_02803 33035.JPJF01000037_gene2983 7.08e-186 518.0 COG0395@1|root,COG0395@2|Bacteria,1V090@1239|Firmicutes,2493G@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_02804 33035.JPJF01000037_gene2984 2.51e-196 544.0 COG1082@1|root,COG1082@2|Bacteria,1UYTA@1239|Firmicutes,24CXC@186801|Clostridia 186801|Clostridia G AP endonuclease family - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_02805 33035.JPJF01000037_gene2985 1.56e-132 378.0 COG5578@1|root,COG5578@2|Bacteria,1V5CK@1239|Firmicutes,24IZD@186801|Clostridia,3Y1SW@572511|Blautia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 KKPNOBBG_02806 33035.JPJF01000037_gene2986 1.72e-290 798.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,3Y14V@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_02807 33035.JPJF01000037_gene2987 4.74e-202 560.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia,3Y176@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02808 33035.JPJF01000037_gene2988 4.06e-172 482.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,3Y0FC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02809 33035.JPJF01000037_gene2989 0.0 1426.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia,3XZMS@572511|Blautia 186801|Clostridia G Glycosyl hydrolase family 36 N-terminal domain - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase KKPNOBBG_02810 33035.JPJF01000037_gene2990 5.32e-222 612.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_02811 33035.JPJF01000037_gene2991 2.22e-199 553.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_02812 33035.JPJF01000037_gene2992 1.12e-174 489.0 COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia 186801|Clostridia S PFAM ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_02813 33035.JPJF01000037_gene2993 1.66e-173 485.0 COG4587@1|root,COG4587@2|Bacteria,1TSAN@1239|Firmicutes,24B28@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 KKPNOBBG_02814 33035.JPJF01000037_gene2994 1.19e-175 491.0 COG3694@1|root,COG3694@2|Bacteria,1TR4N@1239|Firmicutes,24A3T@186801|Clostridia 186801|Clostridia S transport system, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 KKPNOBBG_02816 33035.JPJF01000037_gene2995 3.88e-127 362.0 2C6ZI@1|root,31XAP@2|Bacteria,1V8Q3@1239|Firmicutes,24R7B@186801|Clostridia,3Y0WJ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02817 33035.JPJF01000037_gene2996 3.42e-83 267.0 2FII4@1|root,34AA6@2|Bacteria,1W0M0@1239|Firmicutes,253B6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02819 411461.DORFOR_03195 1.78e-42 139.0 2DP0F@1|root,32UJY@2|Bacteria,1VA60@1239|Firmicutes,24MWB@186801|Clostridia,27X1F@189330|Dorea 186801|Clostridia S Putative tranposon-transfer assisting protein - - - - - - - - - - - - TTRAP KKPNOBBG_02820 657322.FPR_14260 0.0 2149.0 COG0358@1|root,COG4227@1|root,COG0358@2|Bacteria,COG4227@2|Bacteria,1TQN4@1239|Firmicutes,2482H@186801|Clostridia,3WI43@541000|Ruminococcaceae 186801|Clostridia L YodL-like - - - - - - - - - - - - DUF4316,Peptidase_M78,YodL,zf-CHC2 KKPNOBBG_02821 657322.FPR_14250 6.21e-57 177.0 2AFRJ@1|root,315TI@2|Bacteria,1V7X6@1239|Firmicutes,24KY1@186801|Clostridia,3WPG2@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02822 411471.SUBVAR_04337 0.0 1352.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,3WGKN@541000|Ruminococcaceae 186801|Clostridia L DNA topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt KKPNOBBG_02823 428127.EUBDOL_00099 5.83e-152 428.0 28IU3@1|root,2Z8SX@2|Bacteria,1UZB0@1239|Firmicutes,3VSYV@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02824 658086.HMPREF0994_05516 5.41e-43 139.0 2CC3W@1|root,3377Z@2|Bacteria,1VJCT@1239|Firmicutes,24SG5@186801|Clostridia,27Q1H@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02825 657322.FPR_14220 1.23e-155 439.0 28HUZ@1|root,2Z81G@2|Bacteria,1TS04@1239|Firmicutes,24AUT@186801|Clostridia,3WHA3@541000|Ruminococcaceae 186801|Clostridia S Domain of unknown function (DUF4366) - - - - - - - - - - - - DUF4366 KKPNOBBG_02826 658659.HMPREF0983_01763 4.49e-46 149.0 2AF03@1|root,314Y6@2|Bacteria,1V9HG@1239|Firmicutes,3VRVP@526524|Erysipelotrichia 526524|Erysipelotrichia S Domain of unknown function (DUF4315) - - - - - - - - - - - - DUF4315 KKPNOBBG_02827 742735.HMPREF9467_04733 0.0 1117.0 COG0791@1|root,COG0791@2|Bacteria,1TP24@1239|Firmicutes,247K5@186801|Clostridia,21YDK@1506553|Lachnoclostridium 186801|Clostridia M COG COG0791 Cell wall-associated hydrolases (invasion-associated proteins) - - - - - - - - - - - - CHAP KKPNOBBG_02828 411461.DORFOR_03214 2.59e-83 246.0 2DZH5@1|root,32VAM@2|Bacteria,1V1MR@1239|Firmicutes,24GI9@186801|Clostridia,27X15@189330|Dorea 186801|Clostridia S Protein of unknown function (DUF3851) - - - - - - - - - - - - DUF3851 KKPNOBBG_02829 428127.EUBDOL_01403 0.0 1570.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,3VPNT@526524|Erysipelotrichia 526524|Erysipelotrichia U Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_10 KKPNOBBG_02830 658659.HMPREF0983_01767 5.1e-102 295.0 COG3451@1|root,COG3451@2|Bacteria,1V74G@1239|Firmicutes,3VRCI@526524|Erysipelotrichia 526524|Erysipelotrichia U PrgI family protein - - - - - - - - - - - - PrgI KKPNOBBG_02831 428127.EUBDOL_01400 3.28e-198 550.0 28HUM@1|root,2Z81B@2|Bacteria,1TNZ2@1239|Firmicutes,3VQ0C@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_02832 428127.EUBDOL_01399 6.43e-41 135.0 2CDEH@1|root,32RXK@2|Bacteria,1VA17@1239|Firmicutes,3VR9H@526524|Erysipelotrichia 526524|Erysipelotrichia S Maff2 family - - - - - - - - - - - - Maff2 KKPNOBBG_02833 545696.HOLDEFILI_02397 0.0 1210.0 COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,3VP0A@526524|Erysipelotrichia 526524|Erysipelotrichia U Psort location Cytoplasmic, score - - - - - - - - - - - - T4SS-DNA_transf,TraG-D_C KKPNOBBG_02834 657322.FPR_13970 3.08e-108 312.0 28I1B@1|root,2Z860@2|Bacteria,1TT6W@1239|Firmicutes,24BUI@186801|Clostridia,3WNZ8@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function (DUF3801) - - - - - - - - - - - - DUF3801 KKPNOBBG_02835 657322.FPR_13950 2.11e-69 209.0 2B1PF@1|root,2ZAM2@2|Bacteria,1TR61@1239|Firmicutes,248XP@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02836 1519439.JPJG01000107_gene1857 8.28e-84 247.0 29606@1|root,2ZWIP@2|Bacteria,1V5TK@1239|Firmicutes,25HSA@186801|Clostridia,2N90E@216572|Oscillospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02837 742735.HMPREF9467_03087 5.77e-189 527.0 COG3935@1|root,COG3935@2|Bacteria,1TPPF@1239|Firmicutes,249NG@186801|Clostridia,220ZP@1506553|Lachnoclostridium 186801|Clostridia L Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_36,RepA_N KKPNOBBG_02838 742735.HMPREF9467_03086 2.29e-36 122.0 2E5WX@1|root,330KV@2|Bacteria,1VFRK@1239|Firmicutes,24S32@186801|Clostridia,223KS@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02839 742735.HMPREF9467_03085 1.52e-57 178.0 2B1PF@1|root,31U4Y@2|Bacteria,1V8C1@1239|Firmicutes,24K5M@186801|Clostridia,220K2@1506553|Lachnoclostridium 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02840 665956.HMPREF1032_02015 1.15e-208 578.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,3WH74@541000|Ruminococcaceae 186801|Clostridia K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc KKPNOBBG_02841 411470.RUMGNA_00790 5.82e-189 526.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,247R1@186801|Clostridia,3XZBU@572511|Blautia 186801|Clostridia D CobQ CobB MinD ParA nucleotide binding domain protein - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 KKPNOBBG_02842 658086.HMPREF0994_05482 1.97e-297 810.0 COG0582@1|root,COG0582@2|Bacteria,1TT1I@1239|Firmicutes,24C80@186801|Clostridia,27K4H@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_02843 658086.HMPREF0994_05483 3.27e-297 810.0 COG0582@1|root,COG0582@2|Bacteria,1TSR6@1239|Firmicutes,249IV@186801|Clostridia,27KWZ@186928|unclassified Lachnospiraceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_02844 742735.HMPREF9467_03408 9.09e-282 773.0 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,248JG@186801|Clostridia,2234C@1506553|Lachnoclostridium 186801|Clostridia L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,HhH-GPD,Transposase_20 KKPNOBBG_02845 411470.RUMGNA_00705 3.31e-47 151.0 2CBNB@1|root,32UW5@2|Bacteria,1VCKT@1239|Firmicutes,24N2B@186801|Clostridia,3Y1TY@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - HTH_17 KKPNOBBG_02846 658086.HMPREF0994_05485 1.07e-99 290.0 COG1191@1|root,COG1191@2|Bacteria,1VJ1U@1239|Firmicutes,24I8V@186801|Clostridia 186801|Clostridia K sigma factor activity - - - - - - - - - - - - Sigma70_r4 KKPNOBBG_02847 658086.HMPREF0994_05486 4.28e-70 212.0 COG1476@1|root,COG1476@2|Bacteria,1VJIX@1239|Firmicutes 1239|Firmicutes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_02848 658086.HMPREF0994_05487 0.0 877.0 COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,27JZ1@186928|unclassified Lachnospiraceae 186801|Clostridia G ABC transporter - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran KKPNOBBG_02849 658086.HMPREF0994_05488 4.12e-159 446.0 COG0619@1|root,COG0619@2|Bacteria,1UYEH@1239|Firmicutes,24G4P@186801|Clostridia 186801|Clostridia P cobalt transport protein - - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ KKPNOBBG_02850 556261.HMPREF0240_03115 6.75e-42 144.0 28PAD@1|root,2ZC3K@2|Bacteria,1VE36@1239|Firmicutes,25CIN@186801|Clostridia 186801|Clostridia S Hypothetical bacterial integral membrane protein (Trep_Strep) - - - ko:K16926 - M00582 - - ko00000,ko00002,ko02000 3.A.1.31 - - Trep_Strep KKPNOBBG_02851 658086.HMPREF0994_05490 0.0 1065.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247PY@186801|Clostridia,27KAE@186928|unclassified Lachnospiraceae 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_02852 658086.HMPREF0994_05491 0.0 1094.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247VZ@186801|Clostridia,27KP9@186928|unclassified Lachnospiraceae 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_02853 658086.HMPREF0994_05492 4.44e-274 749.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,27IVZ@186928|unclassified Lachnospiraceae 186801|Clostridia E Pyridoxal-phosphate dependent enzyme cysK - 2.5.1.47,4.2.1.22 ko:K01697,ko:K01738 ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021,M00035,M00338 R00891,R00897,R01290,R03601,R04859,R04942 RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_02854 658086.HMPREF0994_05493 0.0 1040.0 COG1123@1|root,COG4172@2|Bacteria,1UZK8@1239|Firmicutes,2511Z@186801|Clostridia,27MWS@186928|unclassified Lachnospiraceae 186801|Clostridia P ATPases associated with a variety of cellular activities - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY KKPNOBBG_02855 658086.HMPREF0994_05494 3.79e-186 518.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,27MC2@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K13891 ko02010,map02010 M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.11 - - BPD_transp_1,OppC_N KKPNOBBG_02856 658086.HMPREF0994_05495 2.02e-221 612.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,27N0H@186928|unclassified Lachnospiraceae 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_02857 658086.HMPREF0994_05496 0.0 1040.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,27JWV@186928|unclassified Lachnospiraceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle oppA2 - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_02858 658086.HMPREF0994_05497 1.55e-273 750.0 COG2270@1|root,COG2270@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K08162,ko:K08226,ko:K16211 - - - - ko00000,ko02000 2.A.1.2.21,2.A.1.41,2.A.2.6 - - MFS_1,PUCC KKPNOBBG_02859 658086.HMPREF0994_05498 1.02e-194 539.0 COG2263@1|root,COG2263@2|Bacteria 2|Bacteria J DNA repair - GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0036260,GO:0036261,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071164,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - - - - - - - - - - Methyltransf_25,Methyltransf_31 KKPNOBBG_02860 658086.HMPREF0994_05499 1.35e-195 541.0 COG2014@1|root,COG2014@2|Bacteria 2|Bacteria F Putative heavy-metal chelation - - - - - - - - - - - - DUF364 KKPNOBBG_02861 658086.HMPREF0994_05500 1.22e-308 840.0 COG2232@1|root,COG2232@2|Bacteria,1UITA@1239|Firmicutes,25F14@186801|Clostridia 186801|Clostridia S ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 KKPNOBBG_02862 658086.HMPREF0994_05501 6.21e-206 569.0 COG0583@1|root,COG0583@2|Bacteria,1UYA4@1239|Firmicutes,24DFQ@186801|Clostridia,27IUB@186928|unclassified Lachnospiraceae 186801|Clostridia K LysR substrate binding domain - - - ko:K19242 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate KKPNOBBG_02863 658086.HMPREF0994_05502 3.14e-117 347.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,2481D@186801|Clostridia,27IPY@186928|unclassified Lachnospiraceae 186801|Clostridia U Relaxase/Mobilisation nuclease domain - - - - - - - - - - - - Relaxase KKPNOBBG_02864 397288.C806_03613 4.96e-82 246.0 COG0454@1|root,COG0456@2|Bacteria,1VCET@1239|Firmicutes,24MTN@186801|Clostridia,27QXV@186928|unclassified Lachnospiraceae 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_02866 33035.JPJF01000016_gene4175 2.73e-152 433.0 2E7DC@1|root,331WG@2|Bacteria,1VGCF@1239|Firmicutes,24QIK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02867 33035.JPJF01000016_gene4176 2.73e-150 426.0 2E7DC@1|root,331WG@2|Bacteria,1VGCF@1239|Firmicutes,24QIK@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02868 33035.JPJF01000016_gene4177 5.77e-67 204.0 2DSEA@1|root,33FSH@2|Bacteria,1VNCF@1239|Firmicutes,24W88@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02869 33035.JPJF01000016_gene4178 1.87e-190 536.0 2BDA6@1|root,326YM@2|Bacteria,1V84X@1239|Firmicutes,24JRS@186801|Clostridia 186801|Clostridia - - - - - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - - KKPNOBBG_02870 33035.JPJF01000016_gene4179 2.64e-96 281.0 COG1225@1|root,COG1225@2|Bacteria,1V3N5@1239|Firmicutes,24HP8@186801|Clostridia,3XZUT@572511|Blautia 186801|Clostridia O Antioxidant, AhpC TSA family bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA KKPNOBBG_02871 33035.JPJF01000016_gene4180 4.87e-45 145.0 COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia 186801|Clostridia K Cold shock protein cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD KKPNOBBG_02872 33035.JPJF01000016_gene4183 0.0 1268.0 COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,24CZV@186801|Clostridia,3Y0KK@572511|Blautia 186801|Clostridia E Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core KKPNOBBG_02873 33035.JPJF01000016_gene4184 4.63e-191 537.0 COG1721@1|root,COG1721@2|Bacteria,1UZHY@1239|Firmicutes,24DE8@186801|Clostridia,3Y0QG@572511|Blautia 186801|Clostridia S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 KKPNOBBG_02874 33035.JPJF01000016_gene4185 5.11e-215 595.0 COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,3XYTD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 9.98 - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 KKPNOBBG_02875 33035.JPJF01000016_gene4186 2.61e-116 337.0 COG0716@1|root,COG0716@2|Bacteria,1UUUV@1239|Firmicutes,25KCS@186801|Clostridia,3Y0VS@572511|Blautia 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4 KKPNOBBG_02876 33035.JPJF01000016_gene4187 2.45e-225 623.0 COG4129@1|root,COG4129@2|Bacteria,1TP2T@1239|Firmicutes,24A4H@186801|Clostridia,3Y207@572511|Blautia 186801|Clostridia S Putative aromatic acid exporter C-terminal domain - - - - - - - - - - - - ArAE_1,ArAE_1_C KKPNOBBG_02877 33035.JPJF01000016_gene4188 5.98e-79 236.0 2BVD7@1|root,32QT8@2|Bacteria,1V6S8@1239|Firmicutes,257S1@186801|Clostridia,3Y0WY@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - DUF2383 KKPNOBBG_02878 33035.JPJF01000095_gene2133 1.37e-221 612.0 COG1432@1|root,COG1432@2|Bacteria,1TTAC@1239|Firmicutes,249NE@186801|Clostridia,3XZ7E@572511|Blautia 186801|Clostridia S NYN domain - - - - - - - - - - - - NYN,OST-HTH KKPNOBBG_02879 33035.JPJF01000095_gene2132 1.31e-141 402.0 2CH8U@1|root,306GF@2|Bacteria,1VDTB@1239|Firmicutes,25AZP@186801|Clostridia 186801|Clostridia S L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase KKPNOBBG_02880 33035.JPJF01000095_gene2131 6.9e-105 305.0 COG0778@1|root,COG0778@2|Bacteria,1V3YJ@1239|Firmicutes,24BKH@186801|Clostridia,3Y1HS@572511|Blautia 186801|Clostridia C Nitroreductase family - - - - - - - - - - - - Nitroreductase,TM1586_NiRdase KKPNOBBG_02882 33035.JPJF01000011_gene1265 1.6e-187 523.0 COG4974@1|root,COG4974@2|Bacteria,1TY7M@1239|Firmicutes,24BN9@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase KKPNOBBG_02883 33035.JPJF01000011_gene1266 7.06e-174 489.0 COG2169@1|root,COG2169@2|Bacteria,1UUUH@1239|Firmicutes,25KCH@186801|Clostridia,3Y21B@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_02884 33035.JPJF01000011_gene1267 1.4e-283 776.0 COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,3Y0NS@572511|Blautia 186801|Clostridia M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - GO:0000287,GO:0003674,GO:0005488,GO:0043167,GO:0043169,GO:0046872 4.2.1.5,4.2.1.8 ko:K01683,ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N KKPNOBBG_02885 33035.JPJF01000011_gene1268 8.95e-110 316.0 COG3871@1|root,COG3871@2|Bacteria,1V49E@1239|Firmicutes,24GGN@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Putative_PNPOx KKPNOBBG_02886 33035.JPJF01000011_gene1269 5.97e-137 389.0 COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,3XZK2@572511|Blautia 186801|Clostridia S Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins ribU - - - - - - - - - - - ECF_trnsprt KKPNOBBG_02887 869209.Tresu_0522 7.62e-92 269.0 2CI1N@1|root,3025Y@2|Bacteria,2J7GV@203691|Spirochaetes 203691|Spirochaetes S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02888 33035.JPJF01000011_gene1274 1.7e-235 647.0 COG1917@1|root,COG1917@2|Bacteria,1VWQR@1239|Firmicutes,24KNE@186801|Clostridia 186801|Clostridia S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2 KKPNOBBG_02889 33035.JPJF01000011_gene1275 3.65e-310 852.0 COG2207@1|root,COG2207@2|Bacteria,1VF9U@1239|Firmicutes,24DGF@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_02890 553973.CLOHYLEM_04314 1.14e-73 244.0 2DBEW@1|root,2Z8UY@2|Bacteria,1UYFJ@1239|Firmicutes,2489J@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF4874) - - - - - - - - - - - - DUF4832,DUF4874 KKPNOBBG_02891 1232453.BAIF02000009_gene3082 1.75e-114 342.0 COG1216@1|root,COG1216@2|Bacteria,1VATJ@1239|Firmicutes,24H9J@186801|Clostridia,268VP@186813|unclassified Clostridiales 186801|Clostridia S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_02892 553973.CLOHYLEM_04316 3.29e-95 294.0 COG1216@1|root,COG1216@2|Bacteria 2|Bacteria V Glycosyl transferase, family 2 - - - - - - - - - - - - Glycos_transf_2,Glyphos_transf KKPNOBBG_02894 553973.CLOHYLEM_04317 3.37e-116 358.0 COG2244@1|root,COG2244@2|Bacteria,1TR1W@1239|Firmicutes,24917@186801|Clostridia,2207Y@1506553|Lachnoclostridium 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 KKPNOBBG_02895 553973.CLOHYLEM_04318 1.76e-201 574.0 COG4267@1|root,COG4267@2|Bacteria,1TRZE@1239|Firmicutes,24EQ7@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K21012 ko02025,map02025 - - - ko00000,ko00001 - - - PelG KKPNOBBG_02896 1232453.BAIF02000009_gene3077 1.05e-247 691.0 COG0438@1|root,COG0438@2|Bacteria,1TQ8U@1239|Firmicutes,24BAM@186801|Clostridia,268AM@186813|unclassified Clostridiales 186801|Clostridia M Domain of unknown function (DUF3492) - - - ko:K21011 ko02025,map02025 - - - ko00000,ko00001,ko01003 - GT4 - DUF3492,Glycos_transf_1 KKPNOBBG_02897 553973.CLOHYLEM_04320 4.84e-89 292.0 28HJQ@1|root,2Z7UU@2|Bacteria,1UPMJ@1239|Firmicutes,24BW1@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DUF2194 KKPNOBBG_02898 556261.HMPREF0240_03378 2.21e-81 251.0 COG1216@1|root,COG1216@2|Bacteria,1UAQP@1239|Firmicutes,25B5D@186801|Clostridia,36WAM@31979|Clostridiaceae 186801|Clostridia S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_02899 556261.HMPREF0240_03377 1.17e-180 541.0 28N1Z@1|root,2ZB7X@2|Bacteria,1UZID@1239|Firmicutes,24F7M@186801|Clostridia,36JXG@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02901 556261.HMPREF0240_03375 5.57e-161 488.0 COG0451@1|root,COG0451@2|Bacteria,1UYUX@1239|Firmicutes,24CYP@186801|Clostridia,36GYR@31979|Clostridiaceae 186801|Clostridia GM Psort location CytoplasmicMembrane, score - - 5.1.3.2 ko:K01784,ko:K21009 ko00052,ko00520,ko01100,ko02025,map00052,map00520,map01100,map02025 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,RmlD_sub_bind KKPNOBBG_02902 1232453.BAIF02000009_gene3070 1.91e-11 64.3 COG2456@1|root,COG2456@2|Bacteria,1VN5U@1239|Firmicutes,24UTR@186801|Clostridia 186801|Clostridia S Uncharacterized conserved protein (DUF2304) - - - ko:K09153 - - - - ko00000 - - - DUF2304 KKPNOBBG_02903 658086.HMPREF0994_06179 1.09e-103 307.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24C2K@186801|Clostridia,27TAQ@186928|unclassified Lachnospiraceae 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_02904 742740.HMPREF9474_02106 8.37e-150 429.0 COG5551@1|root,COG5551@2|Bacteria,1UZCQ@1239|Firmicutes,259UY@186801|Clostridia,22397@1506553|Lachnoclostridium 186801|Clostridia S CRISPR-associated endoribonuclease Cas6 - - - - - - - - - - - - CRISPR_Cas6 KKPNOBBG_02905 33035.JPJF01000031_gene2332 0.0 1075.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TQ85@1239|Firmicutes,25B1P@186801|Clostridia 186801|Clostridia E Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 KKPNOBBG_02906 33035.JPJF01000031_gene2331 5.9e-282 774.0 COG4565@1|root,COG4565@2|Bacteria,1V17X@1239|Firmicutes,24DMG@186801|Clostridia 186801|Clostridia KT transcriptional regulatory protein - - - - - - - - - - - - - KKPNOBBG_02907 33035.JPJF01000031_gene2330 6.36e-259 712.0 COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,3Y0FD@572511|Blautia 186801|Clostridia E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_02908 33035.JPJF01000031_gene2329 2.95e-150 426.0 28N4D@1|root,2ZB9V@2|Bacteria,1UPRR@1239|Firmicutes,24MJV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02909 33035.JPJF01000031_gene2328 6.63e-148 419.0 2DMDC@1|root,32PHK@2|Bacteria,1V728@1239|Firmicutes,24K2A@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF5058) - - - - - - - - - - - - DUF5058 KKPNOBBG_02910 33035.JPJF01000031_gene2327 2.9e-215 595.0 COG2066@1|root,COG2066@2|Bacteria,1TP64@1239|Firmicutes,2491K@186801|Clostridia,3Y153@572511|Blautia 186801|Clostridia E Glutaminase glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase KKPNOBBG_02911 33035.JPJF01000031_gene2326 7.42e-202 560.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3Y16Y@572511|Blautia 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 KKPNOBBG_02912 33035.JPJF01000031_gene2325 5.26e-70 211.0 COG3118@1|root,COG3118@2|Bacteria,1VDSC@1239|Firmicutes,25N64@186801|Clostridia,3Y27F@572511|Blautia 186801|Clostridia O Thioredoxin - - - - - - - - - - - - Thioredoxin KKPNOBBG_02913 33035.JPJF01000031_gene2324 0.0 896.0 COG2986@1|root,COG2986@2|Bacteria,1TQ8I@1239|Firmicutes,24E1T@186801|Clostridia 186801|Clostridia E Aromatic amino acid lyase - - - - - - - - - - - - Lyase_aromatic KKPNOBBG_02914 33035.JPJF01000031_gene2323 6.37e-234 645.0 COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,3Y0AK@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 dlgD - 1.1.1.130 ko:K08092 ko00040,ko00053,map00040,map00053 - R02637,R02639 RC00238 ko00000,ko00001,ko01000 - - - Ldh_2 KKPNOBBG_02915 33035.JPJF01000031_gene2322 0.0 883.0 COG5598@1|root,COG5598@2|Bacteria,1V5NM@1239|Firmicutes,25AYD@186801|Clostridia 186801|Clostridia H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_02916 33035.JPJF01000031_gene2321 1.51e-91 268.0 COG1786@1|root,COG1786@2|Bacteria,1V9ZT@1239|Firmicutes,24N2I@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 KKPNOBBG_02917 33035.JPJF01000031_gene2320 8.71e-312 849.0 COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 KKPNOBBG_02918 33035.JPJF01000031_gene2319 1.49e-87 258.0 COG1786@1|root,COG1786@2|Bacteria,1V4V4@1239|Firmicutes,24I6P@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 KKPNOBBG_02919 33035.JPJF01000031_gene2318 1.49e-292 798.0 COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia,3Y1UT@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 KKPNOBBG_02920 33035.JPJF01000031_gene2317 0.0 900.0 COG2986@1|root,COG2986@2|Bacteria,1TQ8I@1239|Firmicutes,24E1T@186801|Clostridia,3Y0YT@572511|Blautia 186801|Clostridia E Aromatic amino acid lyase - - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic KKPNOBBG_02921 33035.JPJF01000031_gene2316 1.66e-109 316.0 2EATI@1|root,334VA@2|Bacteria,1VFEE@1239|Firmicutes,24QRH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02922 1121296.JONJ01000012_gene407 9.97e-20 89.7 COG0591@1|root,COG0591@2|Bacteria,1V0NB@1239|Firmicutes,24ENM@186801|Clostridia 186801|Clostridia E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF KKPNOBBG_02923 33035.JPJF01000031_gene2314 1.32e-315 862.0 COG0591@1|root,COG0591@2|Bacteria,1V0NB@1239|Firmicutes,24ENM@186801|Clostridia 186801|Clostridia E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF KKPNOBBG_02924 33035.JPJF01000031_gene2313 0.0 877.0 COG5598@1|root,COG5598@2|Bacteria,1V5NM@1239|Firmicutes,25AYD@186801|Clostridia 186801|Clostridia H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_02925 33035.JPJF01000031_gene2312 1.12e-82 246.0 COG0251@1|root,COG0251@2|Bacteria,1TTHQ@1239|Firmicutes,254ZB@186801|Clostridia 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP KKPNOBBG_02926 33035.JPJF01000031_gene2311 8.25e-295 829.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C KKPNOBBG_02927 1226322.HMPREF1545_01618 8.38e-46 147.0 2DNX6@1|root,32ZMR@2|Bacteria,1UM3A@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_02928 742733.HMPREF9469_01293 8.13e-184 516.0 COG3935@1|root,COG3935@2|Bacteria,1TPPF@1239|Firmicutes,249NG@186801|Clostridia,21YC3@1506553|Lachnoclostridium 186801|Clostridia L COG NOG34358 non supervised orthologous group - - - - - - - - - - - - RepA_N KKPNOBBG_02929 742733.HMPREF9469_01292 1.87e-91 269.0 2DBBE@1|root,2Z87W@2|Bacteria,1UYXC@1239|Firmicutes,25CI0@186801|Clostridia,22496@1506553|Lachnoclostridium 186801|Clostridia S Protein of unknown function (DUF3801) - - - - - - - - - - - - DUF3801 KKPNOBBG_02930 1256908.HMPREF0373_01921 0.0 1167.0 COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,2489C@186801|Clostridia,25VAZ@186806|Eubacteriaceae 186801|Clostridia U COG COG3505 Type IV secretory pathway, VirD4 components - - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf,TraG-D_C KKPNOBBG_02931 552396.HMPREF0863_02705 7.27e-42 137.0 2CDEH@1|root,32RXK@2|Bacteria,1VA17@1239|Firmicutes,3VR9H@526524|Erysipelotrichia 526524|Erysipelotrichia S Maff2 family - - - - - - - - - - - - Maff2 KKPNOBBG_02932 552396.HMPREF0863_02706 9.4e-197 546.0 28HUM@1|root,2Z81B@2|Bacteria,1TNZ2@1239|Firmicutes,3VP2T@526524|Erysipelotrichia 526524|Erysipelotrichia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02933 1226322.HMPREF1545_02552 1.67e-226 622.0 COG1032@1|root,COG1032@2|Bacteria,1TRY3@1239|Firmicutes,249Q1@186801|Clostridia,2N82M@216572|Oscillospiraceae 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_02934 1226322.HMPREF1545_02553 4.11e-82 243.0 28PED@1|root,2ZC60@2|Bacteria,1V1JX@1239|Firmicutes,24G6H@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.75 - - - - - - - - - - - - PrgI KKPNOBBG_02935 552396.HMPREF0863_02709 0.0 1547.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,3VPNT@526524|Erysipelotrichia 526524|Erysipelotrichia U Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_10,PrgI KKPNOBBG_02936 1226322.HMPREF1545_02555 2.09e-245 672.0 COG0863@1|root,COG0863@2|Bacteria,1TR56@1239|Firmicutes,248NR@186801|Clostridia 186801|Clostridia L Belongs to the N(4) N(6)-methyltransferase family cfr9IM - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase KKPNOBBG_02937 1226325.HMPREF1548_06064 0.0 1217.0 COG0791@1|root,COG0791@2|Bacteria,1TP24@1239|Firmicutes,247K5@186801|Clostridia,36H24@31979|Clostridiaceae 186801|Clostridia M NlpC P60 family protein - - - - - - - - - - - - NLPC_P60 KKPNOBBG_02938 1226325.HMPREF1548_06063 1.98e-49 157.0 2AF03@1|root,330GW@2|Bacteria,1VHVV@1239|Firmicutes,24KKT@186801|Clostridia,36W0D@31979|Clostridiaceae 186801|Clostridia S Domain of unknown function (DUF4315) - - - - - - - - - - - - DUF4315 KKPNOBBG_02939 742741.HMPREF9475_01924 3.44e-140 399.0 28HUZ@1|root,2Z81G@2|Bacteria,1TS04@1239|Firmicutes,24AUT@186801|Clostridia,21ZXN@1506553|Lachnoclostridium 186801|Clostridia S Domain of unknown function (DUF4366) - - - - - - - - - - - - DUF4366,SH3_3 KKPNOBBG_02940 742741.HMPREF9475_01925 0.0 1344.0 COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,21Z9P@1506553|Lachnoclostridium 186801|Clostridia L Bacterial DNA topoisomeraes I ATP-binding domain topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - Topoisom_bac,Toprim,Toprim_Crpt KKPNOBBG_02941 1226325.HMPREF1548_06059 3.92e-83 245.0 28NID@1|root,2Z9XT@2|Bacteria,1V16A@1239|Firmicutes,24FUK@186801|Clostridia,36KG6@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - Cys_rich_VLP KKPNOBBG_02942 742741.HMPREF9475_01927 0.0 1847.0 COG2003@1|root,COG4227@1|root,COG4734@1|root,COG2003@2|Bacteria,COG4227@2|Bacteria,COG4734@2|Bacteria,1TQN4@1239|Firmicutes,2482H@186801|Clostridia,21ZD6@1506553|Lachnoclostridium 186801|Clostridia L Antirestriction protein (ArdA) - - - - - - - - - - - - ArdA,DUF4316,Peptidase_M78,YodL KKPNOBBG_02943 1226325.HMPREF1548_06057 9.1e-33 114.0 2E9U2@1|root,33400@2|Bacteria,1VGEQ@1239|Firmicutes,24RRM@186801|Clostridia,36SH4@31979|Clostridiaceae 186801|Clostridia S Putative tranposon-transfer assisting protein - - - - - - - - - - - - TTRAP KKPNOBBG_02944 877411.JMMA01000002_gene3035 1.93e-23 97.1 2EJ5W@1|root,33CX3@2|Bacteria,1V8TH@1239|Firmicutes,24QD4@186801|Clostridia,3WJ2W@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02945 1507.HMPREF0262_01054 2.13e-40 137.0 COG1476@1|root,COG1476@2|Bacteria,1UHV0@1239|Firmicutes,25E3M@186801|Clostridia,36UHF@31979|Clostridiaceae 186801|Clostridia K Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - HTH_3 KKPNOBBG_02947 478749.BRYFOR_08936 2.4e-26 103.0 COG0745@1|root,COG0745@2|Bacteria,1VH87@1239|Firmicutes,24KDC@186801|Clostridia 186801|Clostridia KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C KKPNOBBG_02948 1282887.AUJG01000012_gene2194 1.25e-98 313.0 COG2267@1|root,COG2267@2|Bacteria,1UHVZ@1239|Firmicutes,25E4X@186801|Clostridia 186801|Clostridia I Protein of unknown function (DUF2974) - - - - - - - - - - - - DUF2974 KKPNOBBG_02949 1462526.BN990_03474 1.44e-12 70.1 2B66C@1|root,31Z3H@2|Bacteria,1V6U0@1239|Firmicutes,4HJU5@91061|Bacilli,4C5P6@84406|Virgibacillus 91061|Bacilli - - - - - - - - - - - - - - Peptidase_C92 KKPNOBBG_02950 641112.ACOK01000001_gene3525 3.51e-41 146.0 COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,3WJ4W@541000|Ruminococcaceae 186801|Clostridia I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf KKPNOBBG_02951 622312.ROSEINA2194_01907 1.02e-58 184.0 2DGB2@1|root,32U6Z@2|Bacteria,1VB89@1239|Firmicutes,24MUC@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02954 1298920.KI911353_gene3479 1.73e-61 195.0 28PR5@1|root,2ZCD3@2|Bacteria,1V3WQ@1239|Firmicutes,24HCF@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_02955 160799.PBOR_26535 1.04e-113 342.0 COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HB4P@91061|Bacilli,26SFT@186822|Paenibacillaceae 91061|Bacilli T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_02956 478749.BRYFOR_09598 4.35e-113 329.0 COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,248B6@186801|Clostridia 186801|Clostridia K Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_02958 537013.CLOSTMETH_02849 3.98e-171 486.0 COG1063@1|root,COG1063@2|Bacteria,1UZRB@1239|Firmicutes,25BQP@186801|Clostridia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_02959 1196322.A370_02192 4.2e-52 172.0 COG1309@1|root,COG1309@2|Bacteria,1V57I@1239|Firmicutes,24I4N@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_02960 411468.CLOSCI_01947 2.47e-90 273.0 COG0204@1|root,COG0204@2|Bacteria,1TTPK@1239|Firmicutes,24B6K@186801|Clostridia,21XQ4@1506553|Lachnoclostridium 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase KKPNOBBG_02961 742733.HMPREF9469_01119 1.84e-211 592.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,220MG@1506553|Lachnoclostridium 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM KKPNOBBG_02962 478749.BRYFOR_05318 1.16e-53 181.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia 186801|Clostridia C Radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM KKPNOBBG_02964 1414720.CBYM010000020_gene2482 2.7e-178 514.0 COG0657@1|root,COG0657@2|Bacteria,1USHI@1239|Firmicutes,24DIN@186801|Clostridia,36IKW@31979|Clostridiaceae 186801|Clostridia I acetylesterase activity - - - - - - - - - - - - - KKPNOBBG_02965 1280681.AUJZ01000006_gene3498 5.7e-112 344.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,4C1ND@830|Butyrivibrio 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_02966 1280681.AUJZ01000006_gene3497 6.85e-62 205.0 COG2207@1|root,COG2207@2|Bacteria,1V48H@1239|Firmicutes,248BW@186801|Clostridia,4BXQQ@830|Butyrivibrio 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 KKPNOBBG_02967 411902.CLOBOL_06158 6.79e-35 124.0 2E481@1|root,32Z3Y@2|Bacteria,1VFK8@1239|Firmicutes,25FTR@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_02968 1469948.JPNB01000001_gene878 3.32e-100 300.0 COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,24HE5@186801|Clostridia,36GMJ@31979|Clostridiaceae 186801|Clostridia H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein KKPNOBBG_02969 1469948.JPNB01000001_gene871 1.16e-76 243.0 COG0583@1|root,COG0583@2|Bacteria,1TQ6Y@1239|Firmicutes,24KGS@186801|Clostridia,36IZW@31979|Clostridiaceae 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_02970 1211844.CBLM010000003_gene2593 8.82e-309 847.0 COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,3VPXG@526524|Erysipelotrichia 526524|Erysipelotrichia H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - - - - - - - - - - UbiD KKPNOBBG_02971 397288.C806_03344 5.36e-167 475.0 COG0463@1|root,COG0463@2|Bacteria,1TT6C@1239|Firmicutes,248F2@186801|Clostridia,27JTS@186928|unclassified Lachnospiraceae 186801|Clostridia M Glycosyl transferase family 2 kfoC_2 - - - - - - - - - - - Glycos_transf_2 KKPNOBBG_02972 180332.JTGN01000003_gene2112 6.12e-132 375.0 28NMC@1|root,2ZA4G@2|Bacteria,1UYCN@1239|Firmicutes,24ACB@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_02973 1235800.C819_01619 0.0 1384.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,27J28@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_02974 556261.HMPREF0240_02598 4.42e-63 230.0 COG2252@1|root,COG2252@2|Bacteria,1VR82@1239|Firmicutes,24XS8@186801|Clostridia 186801|Clostridia S PERMEase - - - - - - - - - - - - - KKPNOBBG_02975 478749.BRYFOR_09536 0.0 951.0 COG1472@1|root,COG1472@2|Bacteria,1TPH5@1239|Firmicutes,247QP@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 3 N-terminal domain protein - - - - - - - - - - - - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_02976 556261.HMPREF0240_02592 3.76e-239 666.0 COG3290@1|root,COG3290@2|Bacteria,1UZXZ@1239|Firmicutes,24DK3@186801|Clostridia,36VGU@31979|Clostridiaceae 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_02977 556261.HMPREF0240_02591 1.76e-144 412.0 COG3279@1|root,COG3279@2|Bacteria,1TSDB@1239|Firmicutes,24MQ4@186801|Clostridia,36KUT@31979|Clostridiaceae 186801|Clostridia KT response regulator - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_02979 478749.BRYFOR_07194 0.0 932.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,2489F@186801|Clostridia 186801|Clostridia G alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_36C,Glyco_hydro_36N,Melibiase KKPNOBBG_02980 33035.JPJF01000037_gene2942 3.69e-192 549.0 COG1482@1|root,COG1940@1|root,COG1482@2|Bacteria,COG1940@2|Bacteria,1TPKW@1239|Firmicutes 1239|Firmicutes GK ROK family glcK - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI,ROK KKPNOBBG_02981 1235802.C823_04301 0.0 905.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,25UZH@186806|Eubacteriaceae 186801|Clostridia G Phosphoglucomutase phosphomannomutase, alpha beta alpha domain II pgcA - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV KKPNOBBG_02983 33035.JPJF01000037_gene2939 7.9e-245 677.0 COG2152@1|root,COG2152@2|Bacteria,1TNYI@1239|Firmicutes,24A1K@186801|Clostridia 186801|Clostridia G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - 2.4.1.281 ko:K16212 - - R09943 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 KKPNOBBG_02984 33035.JPJF01000037_gene2938 1.15e-184 525.0 COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,24C1F@186801|Clostridia 186801|Clostridia G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) - - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim KKPNOBBG_02985 33035.JPJF01000037_gene2937 1.05e-231 639.0 COG2152@1|root,COG2152@2|Bacteria,1TQE7@1239|Firmicutes,249D0@186801|Clostridia,3Y1DZ@572511|Blautia 186801|Clostridia G beta-1,4-mannooligosaccharide phosphorylase - - 2.4.1.319,2.4.1.320 ko:K18785 - - R10811,R10829 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 KKPNOBBG_02986 478749.BRYFOR_07204 1.38e-152 434.0 COG0395@1|root,COG0395@2|Bacteria,1TSVW@1239|Firmicutes,249KJ@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02987 478749.BRYFOR_07205 6.78e-178 502.0 COG1175@1|root,COG1175@2|Bacteria,1TQHI@1239|Firmicutes,247ZB@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_02988 478749.BRYFOR_07206 2.23e-249 693.0 COG1653@1|root,COG1653@2|Bacteria,1TS0C@1239|Firmicutes,249WW@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_02989 33035.JPJF01000037_gene2932 1.35e-177 502.0 COG1609@1|root,COG1609@2|Bacteria,1TT55@1239|Firmicutes,24A7X@186801|Clostridia,3Y1M1@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_02990 457421.CBFG_00060 7.79e-115 331.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,268WK@186813|unclassified Clostridiales 186801|Clostridia S Maltose acetyltransferase maa - 2.3.1.18,2.3.1.79 ko:K00633,ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_02991 1123075.AUDP01000056_gene2462 4e-263 729.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3WI10@541000|Ruminococcaceae 186801|Clostridia V MATE efflux family protein - - - - - - - - - - - - MatE KKPNOBBG_02992 1211819.CALK01000029_gene2037 3.38e-144 409.0 COG1028@1|root,COG1028@2|Bacteria,1TR1J@1239|Firmicutes,3VP29@526524|Erysipelotrichia 526524|Erysipelotrichia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 KKPNOBBG_02993 658659.HMPREF0983_02825 5.08e-199 555.0 COG2207@1|root,COG2207@2|Bacteria,1VCUV@1239|Firmicutes,3VRY1@526524|Erysipelotrichia 526524|Erysipelotrichia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_02994 476272.RUMHYD_02143 3.97e-195 545.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3XYQ8@572511|Blautia 186801|Clostridia CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_02995 457421.CBFG_00086 2.65e-125 375.0 COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia 186801|Clostridia Q Psort location Cytoplasmic, score - - - - - - - - - - - - Amidohydro_1 KKPNOBBG_02996 742733.HMPREF9469_05919 2.76e-97 297.0 28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,249YA@186801|Clostridia,21ZS1@1506553|Lachnoclostridium 186801|Clostridia P 2-keto-3-deoxygluconate permease kdgT - - ko:K02526 - - - - ko00000,ko02000 2.A.10.1 - - KdgT KKPNOBBG_02997 90371.CY43_16920 8.62e-59 197.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1SYGG@1236|Gammaproteobacteria,3ZK3D@590|Salmonella 1236|Gammaproteobacteria I Catalyzes the reduction of tatronate semialdehyde to D- glycerate garR GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008679,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - iNRG857_1313.NRG857_15520 NAD_binding_11,NAD_binding_2 KKPNOBBG_02998 666686.B1NLA3E_07270 2.32e-165 469.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,4HDCR@91061|Bacilli,1ZDCK@1386|Bacillus 91061|Bacilli G COG3958 Transketolase, C-terminal subunit - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C KKPNOBBG_02999 1122216.AUHW01000001_gene768 6.81e-148 422.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,4H24Q@909932|Negativicutes 909932|Negativicutes G Transketolase, thiamine diphosphate binding domain protein - - - - - - - - - - - - Transketolase_N KKPNOBBG_03000 476272.RUMHYD_02631 3.2e-78 242.0 COG2186@1|root,COG2186@2|Bacteria,1V3VZ@1239|Firmicutes,25MUE@186801|Clostridia,3Y1KV@572511|Blautia 186801|Clostridia K FCD domain - - - - - - - - - - - - FCD,GntR KKPNOBBG_03001 478749.BRYFOR_09472 2.26e-12 66.6 2DU6J@1|root,33P4K@2|Bacteria,1VKXU@1239|Firmicutes,24WA8@186801|Clostridia 186801|Clostridia S Psort location - - - - - - - - - - - - - KKPNOBBG_03003 1121129.KB903373_gene532 5.17e-81 253.0 COG4667@1|root,COG4667@2|Bacteria,4NIX2@976|Bacteroidetes,2FM09@200643|Bacteroidia,22WX4@171551|Porphyromonadaceae 976|Bacteroidetes S Patatin-like phospholipase - - - - - - - - - - - - Patatin KKPNOBBG_03004 1235802.C823_05793 2.81e-36 127.0 COG3279@1|root,COG3279@2|Bacteria,1VAGQ@1239|Firmicutes 1239|Firmicutes KT Response regulator of the LytR AlgR family - - - - - - - - - - - - Response_reg KKPNOBBG_03005 1235792.C808_03951 1.17e-99 297.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24C2K@186801|Clostridia,27TAQ@186928|unclassified Lachnospiraceae 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_03006 1235802.C823_05791 2.2e-192 548.0 COG3290@1|root,COG3290@2|Bacteria,1UY02@1239|Firmicutes,24BV9@186801|Clostridia,25X4Y@186806|Eubacteriaceae 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_03007 573061.Clocel_3279 5.03e-61 192.0 COG0454@1|root,COG0456@2|Bacteria,1VJ9N@1239|Firmicutes,24KBX@186801|Clostridia,36RW9@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_03008 33035.JPJF01000009_gene1471 4.92e-97 285.0 COG0454@1|root,COG0456@2|Bacteria,1V7I8@1239|Firmicutes,24G1V@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_03009 398512.JQKC01000013_gene1504 4.08e-98 290.0 COG0560@1|root,COG0560@2|Bacteria,1V9R7@1239|Firmicutes,25BCS@186801|Clostridia 186801|Clostridia E haloacid dehalogenase-like hydrolase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD KKPNOBBG_03010 658086.HMPREF0994_05665 5.14e-73 224.0 COG1695@1|root,COG1695@2|Bacteria,1UYFE@1239|Firmicutes,24BYB@186801|Clostridia 186801|Clostridia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR KKPNOBBG_03011 658086.HMPREF0994_05664 2.65e-176 500.0 COG2267@1|root,COG2267@2|Bacteria,1V0IY@1239|Firmicutes,24BEP@186801|Clostridia,27MKS@186928|unclassified Lachnospiraceae 186801|Clostridia I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 KKPNOBBG_03012 1196322.A370_00295 2.09e-138 396.0 COG0599@1|root,COG0599@2|Bacteria,1TQGP@1239|Firmicutes,24BPS@186801|Clostridia,36GUB@31979|Clostridiaceae 186801|Clostridia S PFAM Carboxymuconolactone decarboxylase - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD KKPNOBBG_03013 1232446.BAIE02000006_gene2140 1.1e-196 553.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,267S2@186813|unclassified Clostridiales 186801|Clostridia C 4Fe-4S dicluster domain - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17,Fer4_9 KKPNOBBG_03014 1123075.AUDP01000031_gene2140 4.19e-87 256.0 COG1917@1|root,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,249JY@186801|Clostridia,3WGGH@541000|Ruminococcaceae 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 KKPNOBBG_03015 1123075.AUDP01000031_gene2141 2.26e-87 259.0 COG0716@1|root,COG0716@2|Bacteria,1V465@1239|Firmicutes,24DQZ@186801|Clostridia,3WI5A@541000|Ruminococcaceae 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4 KKPNOBBG_03016 610130.Closa_3710 9.77e-68 213.0 COG1309@1|root,COG1309@2|Bacteria,1V7EC@1239|Firmicutes,24JXX@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03017 401473.BDP_1352 2.63e-49 160.0 2E56Q@1|root,32ZZE@2|Bacteria,2H0BM@201174|Actinobacteria,4D1SU@85004|Bifidobacteriales 201174|Actinobacteria - - - - - - - - - - - - - - - KKPNOBBG_03018 478749.BRYFOR_07491 6.43e-176 495.0 COG0583@1|root,COG0583@2|Bacteria,1TQWY@1239|Firmicutes,249N9@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_03019 33035.JPJF01000041_gene334 6.34e-146 414.0 COG3279@1|root,COG3279@2|Bacteria,1UYV2@1239|Firmicutes,24F5U@186801|Clostridia,3Y1SH@572511|Blautia 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_03020 33035.JPJF01000041_gene333 2.31e-204 578.0 COG3290@1|root,COG3290@2|Bacteria,1TPZT@1239|Firmicutes,24DBC@186801|Clostridia,3Y0J1@572511|Blautia 186801|Clostridia T signal transduction protein with a C-terminal ATPase domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_03021 33035.JPJF01000041_gene330 8.38e-114 330.0 COG1835@1|root,COG1835@2|Bacteria,1UG9X@1239|Firmicutes,24DXD@186801|Clostridia,3Y1V6@572511|Blautia 186801|Clostridia I ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_5 KKPNOBBG_03022 33035.JPJF01000041_gene329 1.82e-168 476.0 COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,3Y1EY@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03023 33035.JPJF01000041_gene327 6.47e-55 173.0 2D3XN@1|root,32TFT@2|Bacteria,1VBF8@1239|Firmicutes,24NH8@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_03024 931276.Cspa_c05440 3.62e-56 182.0 COG0454@1|root,COG0456@2|Bacteria,1V3GG@1239|Firmicutes,25B37@186801|Clostridia,36W7Q@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_03025 1226325.HMPREF1548_06278 5.5e-198 559.0 COG1020@1|root,COG1020@2|Bacteria,1UQDB@1239|Firmicutes,25845@186801|Clostridia,36TFF@31979|Clostridiaceae 186801|Clostridia Q Condensation domain - - - - - - - - - - - - Condensation KKPNOBBG_03026 1226325.HMPREF1548_06276 4.07e-104 303.0 COG1309@1|root,COG1309@2|Bacteria,1VAN5@1239|Firmicutes,25BR5@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03027 742733.HMPREF9469_02795 3.42e-167 493.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,21XWD@1506553|Lachnoclostridium 186801|Clostridia NT histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal KKPNOBBG_03028 457421.CBFG_00651 8.2e-64 198.0 2AUBE@1|root,31JZ3@2|Bacteria,1V7V1@1239|Firmicutes,24NJE@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF3788) - - - - - - - - - - - - DUF3788 KKPNOBBG_03029 33035.JPJF01000041_gene307 1.39e-178 500.0 COG2510@1|root,COG2510@2|Bacteria,1V3VG@1239|Firmicutes,247SX@186801|Clostridia,3XZSJ@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K08978 - - - - ko00000,ko02000 2.A.7.2 - - EamA KKPNOBBG_03030 33035.JPJF01000041_gene305 0.0 1028.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,3Y1YN@572511|Blautia 186801|Clostridia C Aldehyde dehydrogenase family mmsA - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh KKPNOBBG_03031 33035.JPJF01000041_gene304 0.0 975.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,3XZKC@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 KKPNOBBG_03032 33035.JPJF01000041_gene303 0.0 2643.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,3XZ5S@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9,Response_reg KKPNOBBG_03033 33035.JPJF01000041_gene302 1.09e-274 753.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,3XYJN@572511|Blautia 186801|Clostridia E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 KKPNOBBG_03034 33035.JPJF01000041_gene301 4.09e-44 145.0 2CFZ9@1|root,307GU@2|Bacteria,1U1NF@1239|Firmicutes,258WC@186801|Clostridia,3Y22Q@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03035 33035.JPJF01000041_gene300 9.02e-37 124.0 COG1476@1|root,COG1476@2|Bacteria,1VEGF@1239|Firmicutes,24QPB@186801|Clostridia 186801|Clostridia K DNA-binding helix-turn-helix protein - - - - - - - - - - - - HTH_3 KKPNOBBG_03036 33035.JPJF01000041_gene299 3.74e-223 618.0 COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia 186801|Clostridia H Methyltransferase MtaA CmuA family hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D KKPNOBBG_03037 33035.JPJF01000041_gene298 0.0 1078.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - - - - - - - - - - - Alpha-amylase,GDE_C,GDE_N,hDGE_amylase KKPNOBBG_03038 33035.JPJF01000041_gene297 6.96e-178 498.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03039 33035.JPJF01000041_gene296 5.82e-192 534.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03040 33035.JPJF01000041_gene295 3.54e-304 832.0 COG1653@1|root,COG1653@2|Bacteria,1V14H@1239|Firmicutes,25B1V@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_03041 33035.JPJF01000041_gene294 0.0 953.0 COG2972@1|root,COG2972@2|Bacteria,1UZQN@1239|Firmicutes,24E85@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - His_kinase KKPNOBBG_03042 33035.JPJF01000041_gene293 1.34e-258 714.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UUV7@1239|Firmicutes,25KCZ@186801|Clostridia,3Y1SF@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_03043 33035.JPJF01000097_gene1712 5.86e-36 130.0 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia,3Y281@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Transposase_31 KKPNOBBG_03045 33035.JPJF01000097_gene1712 6.26e-169 477.0 28JN4@1|root,2Z9EJ@2|Bacteria,1TRQI@1239|Firmicutes,24E4X@186801|Clostridia,3Y281@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Transposase_31 KKPNOBBG_03046 553973.CLOHYLEM_04485 2.67e-43 147.0 2F94V@1|root,341GD@2|Bacteria,1VYDU@1239|Firmicutes,24SFR@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03047 556261.HMPREF0240_02933 1.86e-240 673.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE KKPNOBBG_03048 33035.JPJF01000063_gene3742 6.61e-106 309.0 COG0454@1|root,COG0456@2|Bacteria,1V2CK@1239|Firmicutes,24KFX@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_03049 33035.JPJF01000063_gene3741 4.21e-91 268.0 COG0454@1|root,COG0456@2|Bacteria,1V433@1239|Firmicutes,24HYV@186801|Clostridia,3Y0TX@572511|Blautia 186801|Clostridia K FR47-like protein - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 KKPNOBBG_03051 33035.JPJF01000063_gene3740 1.35e-111 325.0 COG2844@1|root,COG2844@2|Bacteria,1V2GH@1239|Firmicutes,24FRR@186801|Clostridia 186801|Clostridia O HD domain - - - - - - - - - - - - HD KKPNOBBG_03052 33035.JPJF01000063_gene3739 3.55e-271 750.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3XYWG@572511|Blautia 186801|Clostridia O COG COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 KKPNOBBG_03053 33035.JPJF01000063_gene3738 6.94e-169 476.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3XZ40@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - - - - - - - - - - ABC_tran KKPNOBBG_03054 33035.JPJF01000063_gene3737 1.14e-106 313.0 2B7SS@1|root,320Z4@2|Bacteria,1V805@1239|Firmicutes 1239|Firmicutes S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_03055 33035.JPJF01000063_gene3736 1.64e-211 589.0 COG1277@1|root,COG1277@2|Bacteria,1UYRU@1239|Firmicutes,24A07@186801|Clostridia,3XZKS@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 KKPNOBBG_03056 33035.JPJF01000063_gene3734 2.85e-266 729.0 COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,3Y021@572511|Blautia 186801|Clostridia C Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17,Fer4_9 KKPNOBBG_03057 33035.JPJF01000063_gene3733 4.19e-230 640.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1TRZX@1239|Firmicutes,249AI@186801|Clostridia,3XYP2@572511|Blautia 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K20487 ko02020,ko02024,map02020,map02024 M00816 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA KKPNOBBG_03058 1226325.HMPREF1548_02015 2.16e-109 320.0 COG0745@1|root,COG0745@2|Bacteria,1TQ0D@1239|Firmicutes,248WX@186801|Clostridia,36FU1@31979|Clostridiaceae 186801|Clostridia T Regulatory protein - - - ko:K20488 ko02020,ko02024,map02020,map02024 M00816 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_03061 33035.JPJF01000063_gene3727 1.55e-42 139.0 28U5H@1|root,2ZGBC@2|Bacteria,1W496@1239|Firmicutes,2557X@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03062 411490.ANACAC_01083 3.97e-121 352.0 COG0778@1|root,COG2221@1|root,COG0778@2|Bacteria,COG2221@2|Bacteria,1TPKH@1239|Firmicutes,249WN@186801|Clostridia 186801|Clostridia C PFAM Nitroreductase - - - - - - - - - - - - Fer4,Fer4_10,Fer4_4,Fer4_7,Fer4_9,Nitroreductase KKPNOBBG_03063 1226325.HMPREF1548_03185 5.1e-61 189.0 COG0640@1|root,COG0640@2|Bacteria,1V6Z2@1239|Firmicutes,24JUM@186801|Clostridia,36KVY@31979|Clostridiaceae 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - HTH_5 KKPNOBBG_03064 742733.HMPREF9469_04174 1.92e-122 355.0 COG0716@1|root,COG1149@1|root,COG0716@2|Bacteria,COG1149@2|Bacteria,1V767@1239|Firmicutes,24C3D@186801|Clostridia,21Z19@1506553|Lachnoclostridium 186801|Clostridia C binding domain protein - - - - - - - - - - - - Fer4,Fer4_4,Fer4_9,Flavodoxin_5 KKPNOBBG_03065 33035.JPJF01000063_gene3724 6.13e-103 301.0 COG1595@1|root,COG1595@2|Bacteria,1V84D@1239|Firmicutes,25B29@186801|Clostridia 186801|Clostridia K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_03066 33035.JPJF01000063_gene3723 3.9e-127 367.0 2FFUY@1|root,347S0@2|Bacteria,1VYP7@1239|Firmicutes,253QZ@186801|Clostridia,3Y23M@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03067 33035.JPJF01000063_gene3722 4.1e-177 497.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3XZE4@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC_tran KKPNOBBG_03068 33035.JPJF01000063_gene3721 9.59e-180 510.0 COG1277@1|root,COG1277@2|Bacteria,1VWKS@1239|Firmicutes,25M9V@186801|Clostridia,3Y21D@572511|Blautia 186801|Clostridia S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - - KKPNOBBG_03069 33035.JPJF01000063_gene3720 0.0 1352.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3Y15E@572511|Blautia 186801|Clostridia G Beta-galactosidase - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_03070 33035.JPJF01000063_gene3712 1.41e-303 828.0 COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,3XZ9R@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC KKPNOBBG_03071 33035.JPJF01000063_gene3711 8.88e-147 415.0 COG0637@1|root,COG0637@2|Bacteria,1VA5Z@1239|Firmicutes,24JNY@186801|Clostridia,3Y042@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HAD_2,Mannitol_dh_C KKPNOBBG_03072 33035.JPJF01000063_gene3710 0.0 920.0 COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,3XZ4X@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PEP-utilizers,PK,PK_C KKPNOBBG_03073 33035.JPJF01000063_gene3709 3.06e-193 536.0 COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia,3XYV8@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Rhomboid KKPNOBBG_03074 33035.JPJF01000063_gene3708 1.83e-207 575.0 COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,3XZ0H@572511|Blautia 186801|Clostridia P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA KKPNOBBG_03075 33035.JPJF01000063_gene3707 1.69e-259 710.0 COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,248JF@186801|Clostridia,3XZ28@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase KKPNOBBG_03076 33035.JPJF01000063_gene3706 1.06e-260 714.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XZIF@572511|Blautia 186801|Clostridia P Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system potA - 3.6.3.31 ko:K11072 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.11.1 - - ABC_tran,TOBE_2 KKPNOBBG_03077 33035.JPJF01000063_gene3705 3.93e-181 505.0 COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,3XYI0@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 potB - - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 KKPNOBBG_03078 33035.JPJF01000063_gene3704 0.0 1169.0 COG0687@1|root,COG1177@1|root,COG0687@2|Bacteria,COG1177@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia,3XZ62@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 potD - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1,SBP_bac_6,SBP_bac_8 KKPNOBBG_03079 33035.JPJF01000063_gene3703 7.42e-175 492.0 COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,3XYU7@572511|Blautia 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD_2 - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 KKPNOBBG_03080 33035.JPJF01000063_gene3702 2.9e-68 207.0 arCOG03368@1|root,331XD@2|Bacteria,1VHY0@1239|Firmicutes,24SSZ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03081 33035.JPJF01000063_gene3701 1.52e-112 323.0 COG4702@1|root,COG4702@2|Bacteria,1V6Q9@1239|Firmicutes,24KK6@186801|Clostridia,3Y0ZS@572511|Blautia 186801|Clostridia S Haem-degrading - - - - - - - - - - - - Haem_degrading KKPNOBBG_03082 33035.JPJF01000063_gene3700 1.3e-238 656.0 COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3XZHE@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b KKPNOBBG_03083 357809.Cphy_3231 2.16e-57 182.0 COG0454@1|root,COG0456@2|Bacteria,1V71C@1239|Firmicutes,24JY8@186801|Clostridia 186801|Clostridia K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 KKPNOBBG_03084 33035.JPJF01000063_gene3697 8.2e-180 513.0 2BF19@1|root,328T3@2|Bacteria,1VAXF@1239|Firmicutes,258NW@186801|Clostridia,3Y0UJ@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03085 33035.JPJF01000063_gene3696 4.1e-224 637.0 COG0845@1|root,COG0845@2|Bacteria,1V156@1239|Firmicutes,24E26@186801|Clostridia,3Y06F@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_03086 33035.JPJF01000063_gene3695 2.86e-182 509.0 COG0395@1|root,COG0395@2|Bacteria,1TS82@1239|Firmicutes,2488S@186801|Clostridia,3XYW1@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03087 33035.JPJF01000063_gene3694 4.89e-184 514.0 COG1175@1|root,COG1175@2|Bacteria,1TQTC@1239|Firmicutes,24AQX@186801|Clostridia,3Y0K9@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03088 33035.JPJF01000063_gene3693 0.0 1181.0 COG1653@1|root,COG1653@2|Bacteria,1V04I@1239|Firmicutes,247SU@186801|Clostridia,3XZJE@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03089 33035.JPJF01000063_gene3692 1.27e-150 424.0 COG0745@1|root,COG0745@2|Bacteria,1UZIS@1239|Firmicutes,24CCE@186801|Clostridia,3XYX9@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03090 33035.JPJF01000063_gene3691 5.27e-273 752.0 COG5002@1|root,COG5002@2|Bacteria,1URKI@1239|Firmicutes,248WK@186801|Clostridia,3XZE3@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_03091 33035.JPJF01000063_gene3690 7.7e-110 316.0 COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,3XZVQ@572511|Blautia 186801|Clostridia H Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) luxS - 4.4.1.21 ko:K07173 ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111 M00609 R01291 RC00069,RC01929 ko00000,ko00001,ko00002,ko01000 - - - LuxS KKPNOBBG_03092 33035.JPJF01000063_gene3689 5.13e-192 535.0 COG5001@1|root,COG5001@2|Bacteria 2|Bacteria T cyclic-guanylate-specific phosphodiesterase activity - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CHASE4,CheB_methylest,CheR,CheR_N,EAL,GGDEF,PAS_3,PAS_9,SBP_bac_3 KKPNOBBG_03093 33035.JPJF01000063_gene3688 2.93e-54 171.0 COG1396@1|root,COG1396@2|Bacteria,1VIXK@1239|Firmicutes,24T9B@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_03094 33035.JPJF01000063_gene3687 8.02e-267 738.0 COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,24NSX@186801|Clostridia,3Y0EX@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 KKPNOBBG_03095 33035.JPJF01000063_gene3686 3.16e-171 480.0 COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,3XZWY@572511|Blautia 186801|Clostridia S COG COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - NTP_transf_3 KKPNOBBG_03096 33035.JPJF01000063_gene3685 1.03e-120 347.0 COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,3Y06N@572511|Blautia 186801|Clostridia O COG NOG13230 non supervised orthologous group yedF - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE,TusA KKPNOBBG_03097 33035.JPJF01000063_gene3684 3.63e-306 837.0 COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,3XZ6S@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 hydA - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 KKPNOBBG_03098 33035.JPJF01000063_gene3683 0.0 1650.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3XYY3@572511|Blautia 186801|Clostridia C COG COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 KKPNOBBG_03099 33035.JPJF01000063_gene3682 1.56e-46 149.0 2DNWW@1|root,32ZKQ@2|Bacteria,1VEZD@1239|Firmicutes,24REP@186801|Clostridia,3Y2CR@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF3343) - - - - - - - - - - - - DUF3343 KKPNOBBG_03100 33035.JPJF01000063_gene3681 3.82e-148 417.0 COG2964@1|root,COG2964@2|Bacteria,1TSI2@1239|Firmicutes,249X6@186801|Clostridia,3XZQ3@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - HTH_22,PAS_6 KKPNOBBG_03101 33035.JPJF01000063_gene3680 1.27e-293 801.0 COG1171@1|root,COG1171@2|Bacteria,1TR70@1239|Firmicutes,2485T@186801|Clostridia,3XZ80@572511|Blautia 186801|Clostridia E Pyridoxal-phosphate dependent enzyme dpaL - 4.3.1.15 ko:K01751 - - - - ko00000,ko01000 - - - PALP KKPNOBBG_03102 33035.JPJF01000063_gene3679 6.77e-313 851.0 COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,3XYM0@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_03103 33035.JPJF01000063_gene3678 3.92e-290 791.0 COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,3XYQV@572511|Blautia 186801|Clostridia E Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain ygeW - - - - - - - - - - - OTCace,OTCace_N KKPNOBBG_03104 33035.JPJF01000063_gene3677 1.78e-215 596.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3XZFB@572511|Blautia 186801|Clostridia E Amino acid kinase family arcC - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase KKPNOBBG_03105 33035.JPJF01000063_gene3676 9.7e-228 627.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3XYQ8@572511|Blautia 186801|Clostridia CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_03106 33035.JPJF01000063_gene3675 2.06e-200 555.0 COG0287@1|root,COG0287@2|Bacteria,1UI17@1239|Firmicutes,24BWB@186801|Clostridia,3Y0X0@572511|Blautia 186801|Clostridia E Phosphogluconate dehydrogenase (decarboxylating) C-term - - - - - - - - - - - - IlvN,PGDH_C KKPNOBBG_03107 1235799.C818_01679 7.68e-178 500.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,27IMD@186928|unclassified Lachnospiraceae 186801|Clostridia G overlaps another CDS with the same product name - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C KKPNOBBG_03108 33035.JPJF01000132_gene4476 8.38e-193 535.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,24C5C@186801|Clostridia,3Y17R@572511|Blautia 186801|Clostridia G Transketolase, thiamine diphosphate binding domain - - - - - - - - - - - - Transketolase_N KKPNOBBG_03109 33035.JPJF01000053_gene1621 8.46e-223 621.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,3XZAD@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM KKPNOBBG_03110 33035.JPJF01000053_gene1620 1.81e-91 270.0 COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,24HA7@186801|Clostridia 186801|Clostridia G COG COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - - - - - - - - - - DctQ KKPNOBBG_03111 33035.JPJF01000053_gene1619 1.33e-212 592.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,3Y06Q@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_03112 33035.JPJF01000053_gene1618 1.8e-142 404.0 COG2186@1|root,COG2186@2|Bacteria,1TSWM@1239|Firmicutes 1239|Firmicutes K FCD domain - - - - - - - - - - - - FCD,GntR KKPNOBBG_03113 33035.JPJF01000053_gene1617 3.62e-154 434.0 COG2186@1|root,COG2186@2|Bacteria,1TSWM@1239|Firmicutes,24GNA@186801|Clostridia,3Y10R@572511|Blautia 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - FCD,GntR KKPNOBBG_03114 33035.JPJF01000053_gene1616 0.0 1384.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia 186801|Clostridia G beta-galactosidase - - - - - - - - - - - - Glyco_hydro_42M KKPNOBBG_03115 33035.JPJF01000053_gene1615 0.0 1533.0 COG3250@1|root,COG3250@2|Bacteria,1UZDI@1239|Firmicutes,24C7N@186801|Clostridia 186801|Clostridia G Glycosyl hydrolases family 2, sugar binding domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_N KKPNOBBG_03116 33035.JPJF01000053_gene1614 0.0 914.0 COG1070@1|root,COG1070@2|Bacteria,1VS1J@1239|Firmicutes,24YN2@186801|Clostridia 186801|Clostridia G FGGY family of carbohydrate kinases, N-terminal domain - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_03117 33035.JPJF01000053_gene1613 2.69e-131 375.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,3XZXA@572511|Blautia 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC KKPNOBBG_03118 33035.JPJF01000053_gene1612 2.38e-246 677.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3XZWH@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_03119 33035.JPJF01000053_gene1611 1.59e-225 624.0 COG1063@1|root,COG1063@2|Bacteria,1U9ZD@1239|Firmicutes,24EJR@186801|Clostridia,3Y2BF@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_03120 33035.JPJF01000053_gene1610 1.26e-193 540.0 COG2390@1|root,COG2390@2|Bacteria,1TPUB@1239|Firmicutes,25D2S@186801|Clostridia,3Y1VG@572511|Blautia 186801|Clostridia K Putative sugar-binding domain deoR - - ko:K05346 - - - - ko00000,ko03000 - - - HTH_23,HTH_24,Sigma70_r4,Sugar-bind KKPNOBBG_03121 33035.JPJF01000053_gene1609 1.05e-176 494.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3Y2B5@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03122 33035.JPJF01000053_gene1608 2.23e-205 569.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03123 33035.JPJF01000053_gene1607 1.83e-314 859.0 COG1653@1|root,COG1653@2|Bacteria,1TSHR@1239|Firmicutes,24D6W@186801|Clostridia 1239|Firmicutes G Extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03124 33035.JPJF01000053_gene1606 0.0 1462.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_03125 33035.JPJF01000053_gene1605 9.45e-126 358.0 COG3822@1|root,COG3822@2|Bacteria,1V1ZU@1239|Firmicutes,24ENY@186801|Clostridia 186801|Clostridia S ABC-type sugar transport system, auxiliary component - - 5.3.1.15 ko:K09988 ko00040,map00040 - R01898 RC00516 ko00000,ko00001,ko01000 - - - Lyx_isomer KKPNOBBG_03127 33035.JPJF01000053_gene1604 4.32e-232 639.0 COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia 186801|Clostridia EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_03128 33035.JPJF01000053_gene1603 4.03e-285 782.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3XYYB@572511|Blautia 186801|Clostridia S COG COG1253 Hemolysins and related proteins containing CBS domains - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 KKPNOBBG_03129 33035.JPJF01000053_gene1602 6.17e-124 354.0 COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,3XZYB@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 sigH - - ko:K03091 - - - - ko00000,ko03021 - - - GerE,Sigma70_r2,Sigma70_r4_2 KKPNOBBG_03130 33035.JPJF01000053_gene1601 1.61e-169 474.0 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,3XZ93@572511|Blautia 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family yacO - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind KKPNOBBG_03131 33035.JPJF01000053_gene1600 7.23e-92 270.0 COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,3Y00G@572511|Blautia 186801|Clostridia J Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) mrnC - - ko:K11145 - - - - ko00000,ko01000,ko03009 - - - Ribonuclease_3 KKPNOBBG_03132 33035.JPJF01000053_gene1599 0.0 904.0 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3XZA4@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g KKPNOBBG_03133 33035.JPJF01000053_gene1598 1.38e-148 419.0 COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,3XYRQ@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N KKPNOBBG_03135 1378168.N510_01972 2.87e-79 269.0 COG2199@1|root,COG2199@2|Bacteria,1V8BN@1239|Firmicutes 1239|Firmicutes T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3,dCache_1 KKPNOBBG_03136 33035.JPJF01000053_gene1596 0.0 1306.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3XZE8@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,Response_reg KKPNOBBG_03137 556268.OFAG_01023 2.42e-163 518.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 KKPNOBBG_03138 33035.JPJF01000053_gene1595 1.34e-314 857.0 COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,3XZ9J@572511|Blautia 186801|Clostridia C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.3,1.4.1.4 ko:K00261,ko:K00262 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N KKPNOBBG_03139 33035.JPJF01000053_gene1594 0.0 1004.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3XYSE@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score yfmM - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn KKPNOBBG_03140 33035.JPJF01000053_gene1593 3.66e-115 331.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,3XZW5@572511|Blautia 186801|Clostridia H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB KKPNOBBG_03141 33035.JPJF01000053_gene1592 0.0 1471.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3XZ6B@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score actP - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase KKPNOBBG_03142 33035.JPJF01000053_gene1591 2.12e-50 160.0 COG1937@1|root,COG1937@2|Bacteria,1USSN@1239|Firmicutes,25AU5@186801|Clostridia,3Y0HY@572511|Blautia 186801|Clostridia S Metal-sensitive transcriptional repressor - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal KKPNOBBG_03143 33035.JPJF01000053_gene1590 8.66e-232 639.0 COG3250@1|root,COG3250@2|Bacteria,1TSMY@1239|Firmicutes,24B54@186801|Clostridia 186801|Clostridia G Protein of unknown function (DUF2804) - - - - - - - - - - - - DUF2804 KKPNOBBG_03144 33035.JPJF01000053_gene1589 1.31e-168 473.0 COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,3XYRK@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 zupT - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip KKPNOBBG_03145 33035.JPJF01000053_gene1588 9.42e-83 246.0 COG0716@1|root,COG0716@2|Bacteria,1V6D7@1239|Firmicutes,24J7W@186801|Clostridia,3Y024@572511|Blautia 186801|Clostridia C Flavodoxin domain - - - - - - - - - - - - Flavodoxin_1 KKPNOBBG_03146 33035.JPJF01000053_gene1587 1.53e-114 330.0 2BYWB@1|root,32SGE@2|Bacteria,1VAZ2@1239|Firmicutes,24J86@186801|Clostridia,3Y04A@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF3793 KKPNOBBG_03147 33035.JPJF01000053_gene1586 1.68e-60 186.0 2DMMF@1|root,32SEK@2|Bacteria,1VAB3@1239|Firmicutes,24N8S@186801|Clostridia,3Y0F2@572511|Blautia 186801|Clostridia S COG NOG21970 non supervised orthologous group - - - - - - - - - - - - DUF2325 KKPNOBBG_03148 33035.JPJF01000053_gene1585 2.41e-183 510.0 COG1234@1|root,COG1234@2|Bacteria,1TPSW@1239|Firmicutes,249RR@186801|Clostridia,3XYRY@572511|Blautia 186801|Clostridia S Metallo-beta-lactamase superfamily - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 KKPNOBBG_03149 33035.JPJF01000053_gene1584 7.67e-95 278.0 COG4194@1|root,COG4194@2|Bacteria,1V3Z3@1239|Firmicutes,24KZ8@186801|Clostridia,3Y1WD@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF1648) - - - - - - - - - - - - DUF1648 KKPNOBBG_03150 33035.JPJF01000053_gene1583 0.0 1008.0 COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,24A4Z@186801|Clostridia,3XYGM@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 araB - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_03151 33035.JPJF01000053_gene1582 1.91e-167 467.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,3XYMH@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 araD - 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II KKPNOBBG_03152 33035.JPJF01000053_gene1581 0.0 1045.0 COG1069@1|root,COG1069@2|Bacteria,1UHVR@1239|Firmicutes,25E4P@186801|Clostridia 186801|Clostridia C Belongs to the FGGY kinase family - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_03153 33035.JPJF01000053_gene1580 6.61e-256 702.0 COG1609@1|root,COG1609@2|Bacteria,1TP9Q@1239|Firmicutes,24ARJ@186801|Clostridia,3Y051@572511|Blautia 186801|Clostridia K Periplasmic binding protein-like domain araR - - ko:K02103 - - - - ko00000,ko03000 - - - GntR,Peripla_BP_3 KKPNOBBG_03154 33035.JPJF01000053_gene1579 1.1e-233 644.0 COG3012@1|root,COG3012@2|Bacteria,1UK0V@1239|Firmicutes,24DYG@186801|Clostridia 186801|Clostridia S SEC-C Motif Domain Protein - - - - - - - - - - - - PRiA4_ORF3 KKPNOBBG_03155 33035.JPJF01000053_gene1578 1.44e-156 439.0 COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia,3Y0AC@572511|Blautia 186801|Clostridia S cog cog2013 - - - - - - - - - - - - AIM24 KKPNOBBG_03156 33035.JPJF01000053_gene1577 1.38e-74 226.0 COG0494@1|root,COG0494@2|Bacteria,1UHVA@1239|Firmicutes,24PC0@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX KKPNOBBG_03157 33035.JPJF01000053_gene1576 2.65e-157 448.0 COG0454@1|root,COG1670@1|root,COG0456@2|Bacteria,COG1670@2|Bacteria,1VAFS@1239|Firmicutes,24MUI@186801|Clostridia,3Y0CK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K03826 - - - - ko00000,ko01000 - - - Acetyltransf_10,Acetyltransf_7 KKPNOBBG_03158 33035.JPJF01000053_gene1575 1.14e-123 355.0 COG2020@1|root,COG2020@2|Bacteria,1V3IZ@1239|Firmicutes,24FW3@186801|Clostridia 186801|Clostridia O Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - DUF218,PEMT KKPNOBBG_03159 33035.JPJF01000053_gene1574 5.19e-197 547.0 COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia 186801|Clostridia L Radical SAM domain protein - - - - - - - - - - - - Radical_SAM KKPNOBBG_03160 33035.JPJF01000053_gene1572 3.11e-127 366.0 COG1418@1|root,COG1418@2|Bacteria,1V2RJ@1239|Firmicutes,25B26@186801|Clostridia 186801|Clostridia S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD KKPNOBBG_03161 1294142.CINTURNW_1533 2.57e-198 556.0 COG3541@1|root,COG3541@2|Bacteria,1UZ8D@1239|Firmicutes,24AZG@186801|Clostridia,36EAD@31979|Clostridiaceae 186801|Clostridia S Predicted nucleotidyltransferase - - - ko:K07074 - - - - ko00000 - - - Nuc-transf KKPNOBBG_03162 33035.JPJF01000053_gene1570 5.14e-136 387.0 2C5Z2@1|root,32TBG@2|Bacteria,1V65A@1239|Firmicutes,25DSJ@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF3786) - - - - - - - - - - - - DUF3786 KKPNOBBG_03163 658086.HMPREF0994_02253 1.69e-76 229.0 2E49F@1|root,32Z57@2|Bacteria,1VA75@1239|Firmicutes,24NSI@186801|Clostridia,27QGE@186928|unclassified Lachnospiraceae 186801|Clostridia S Domain of unknown function (DUF4180) - - - - - - - - - - - - DUF4180 KKPNOBBG_03164 658086.HMPREF0994_02252 4.35e-123 352.0 COG1309@1|root,COG1309@2|Bacteria,1V0XA@1239|Firmicutes,24M3A@186801|Clostridia,27KGU@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03165 1232447.BAHW02000040_gene2766 1.34e-44 146.0 2C5R4@1|root,2ZC1N@2|Bacteria,1V292@1239|Firmicutes,25CQM@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - TnpV KKPNOBBG_03166 33035.JPJF01000014_gene4811 2.53e-15 70.1 2DJ8W@1|root,30516@2|Bacteria,1TUX7@1239|Firmicutes,25I10@186801|Clostridia,3Y21N@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03167 33035.JPJF01000051_gene723 0.0 879.0 COG0437@1|root,COG4624@1|root,COG0437@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,3XYSR@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Fe_hyd_lg_C,Fer4,Fer4_6 KKPNOBBG_03168 33035.JPJF01000051_gene724 2.61e-168 473.0 COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,3XZZ8@572511|Blautia 186801|Clostridia HP ATPases associated with a variety of cellular activities fhuC - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran KKPNOBBG_03169 33035.JPJF01000051_gene725 2.67e-183 516.0 COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,24BGM@186801|Clostridia,3Y1D1@572511|Blautia 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD KKPNOBBG_03170 33035.JPJF01000051_gene726 5.83e-199 556.0 COG0609@1|root,COG0609@2|Bacteria,1TP13@1239|Firmicutes,25CHH@186801|Clostridia 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD KKPNOBBG_03171 33035.JPJF01000051_gene727 1.28e-198 555.0 COG0614@1|root,COG0614@2|Bacteria,1TQMK@1239|Firmicutes,24B1M@186801|Clostridia 186801|Clostridia P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - HTH_18,Peripla_BP_2 KKPNOBBG_03172 33035.JPJF01000051_gene728 7.68e-179 504.0 COG2207@1|root,COG2207@2|Bacteria,1V0EE@1239|Firmicutes,25B24@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_03173 33035.JPJF01000051_gene729 8.79e-123 351.0 COG1670@1|root,COG1670@2|Bacteria,1V6E0@1239|Firmicutes,24G2M@186801|Clostridia,3Y1JZ@572511|Blautia 186801|Clostridia J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 KKPNOBBG_03174 33035.JPJF01000051_gene730 1.48e-152 432.0 COG3231@1|root,COG3231@2|Bacteria,1V0NN@1239|Firmicutes,24CPV@186801|Clostridia 186801|Clostridia J Phosphotransferase enzyme family - - 2.7.1.95 ko:K00897,ko:K19299 - - - - br01600,ko00000,ko01000,ko01504 - - - APH KKPNOBBG_03175 33035.JPJF01000051_gene731 3.75e-88 260.0 COG0454@1|root,COG0456@2|Bacteria,1V6P2@1239|Firmicutes,24NU3@186801|Clostridia 186801|Clostridia K Acetyltransferase, gnat family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 KKPNOBBG_03176 1392491.JIAE01000001_gene697 1.98e-77 243.0 COG0500@1|root,COG0500@2|Bacteria,1UZQD@1239|Firmicutes,24H3J@186801|Clostridia,3WIZ2@541000|Ruminococcaceae 186801|Clostridia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 KKPNOBBG_03177 33035.JPJF01000051_gene732 3.57e-143 404.0 COG1051@1|root,COG1051@2|Bacteria,1U7WX@1239|Firmicutes,2496B@186801|Clostridia 186801|Clostridia F Hydrolase, nudix family - - - - - - - - - - - - NUDIX,Nudix_N KKPNOBBG_03178 1151292.QEW_4308 5.4e-22 92.0 COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TTBP@1239|Firmicutes,25B7Q@186801|Clostridia 186801|Clostridia KT transcriptional regulator, MerR family - - - - - - - - - - - - GyrI-like,MerR_1 KKPNOBBG_03179 1211844.CBLM010000066_gene3121 6.56e-85 259.0 COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1TTBP@1239|Firmicutes,3VPSW@526524|Erysipelotrichia 526524|Erysipelotrichia KT Bacterial transcription activator, effector binding domain - - - - - - - - - - - - MerR_1 KKPNOBBG_03180 1151292.QEW_4309 1.99e-182 515.0 COG4990@1|root,COG4990@2|Bacteria,1TV6G@1239|Firmicutes,24C6X@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - BtrH_N,DUF4872 KKPNOBBG_03181 536227.CcarbDRAFT_1642 1.01e-99 296.0 COG1073@1|root,COG1073@2|Bacteria,1U9AI@1239|Firmicutes,24B6Z@186801|Clostridia,36F9A@31979|Clostridiaceae 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 KKPNOBBG_03182 556261.HMPREF0240_02252 1.88e-208 588.0 COG0477@1|root,COG2814@2|Bacteria,1UHUR@1239|Firmicutes,25E36@186801|Clostridia,36FBN@31979|Clostridiaceae 186801|Clostridia EGP Major Facilitator - - - - - - - - - - - - MFS_1,MFS_3 KKPNOBBG_03183 1226325.HMPREF1548_03146 2.48e-139 402.0 COG4989@1|root,COG4989@2|Bacteria,1TQ12@1239|Firmicutes,248NF@186801|Clostridia,36F2U@31979|Clostridiaceae 186801|Clostridia S aldo keto reductase - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_03184 658086.HMPREF0994_04545 4.27e-180 521.0 COG3395@1|root,COG3395@2|Bacteria,1TRZ8@1239|Firmicutes,24BPN@186801|Clostridia,27QUN@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative nucleotide-binding of sugar-metabolising enzyme - - - - - - - - - - - - DUF1357_C,DUF1537 KKPNOBBG_03185 658086.HMPREF0994_04547 1.32e-256 707.0 COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia,27TAG@186928|unclassified Lachnospiraceae 1239|Firmicutes S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03186 658086.HMPREF0994_04548 5.26e-155 440.0 COG1082@1|root,COG1082@2|Bacteria,1UZ90@1239|Firmicutes,24DP0@186801|Clostridia,27JIM@186928|unclassified Lachnospiraceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03187 658086.HMPREF0994_04549 7.7e-242 668.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,27JMZ@186928|unclassified Lachnospiraceae 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03188 658086.HMPREF0994_04550 6.12e-165 464.0 COG1082@1|root,COG1082@2|Bacteria,1TSK3@1239|Firmicutes,24DCC@186801|Clostridia 186801|Clostridia G PFAM Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03189 658086.HMPREF0994_04551 0.0 975.0 COG1653@1|root,COG1653@2|Bacteria,1TPHG@1239|Firmicutes,24AFQ@186801|Clostridia,27J6A@186928|unclassified Lachnospiraceae 186801|Clostridia G ABC transporter substrate-binding protein - - - ko:K02027,ko:K17318 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03190 658086.HMPREF0994_04552 1.6e-169 478.0 COG0395@1|root,COG0395@2|Bacteria,1TRB1@1239|Firmicutes,2488P@186801|Clostridia,27MH0@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026,ko:K17320 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03191 658086.HMPREF0994_04553 4.74e-185 519.0 COG4209@1|root,COG4209@2|Bacteria,1TSTC@1239|Firmicutes,24AFM@186801|Clostridia,27M8N@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K17319 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03192 658086.HMPREF0994_04555 1.41e-294 810.0 COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia,27J0T@186928|unclassified Lachnospiraceae 186801|Clostridia G L-fucose isomerase, C-terminal domain - - - - - - - - - - - - Arabinose_Isome,Fucose_iso_C KKPNOBBG_03193 658086.HMPREF0994_04556 8.76e-128 372.0 COG0191@1|root,COG0191@2|Bacteria,1UYHC@1239|Firmicutes,24C26@186801|Clostridia 2|Bacteria G Fructose-bisphosphate aldolase class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase KKPNOBBG_03194 658086.HMPREF0994_04557 7.29e-164 463.0 COG1082@1|root,COG1082@2|Bacteria,1VBV1@1239|Firmicutes,252TF@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03195 658086.HMPREF0994_04558 3.02e-132 382.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03196 658086.HMPREF0994_04559 1.76e-133 388.0 COG0524@1|root,COG0524@2|Bacteria 2|Bacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15,2.7.1.184,2.7.1.4 ko:K00847,ko:K00852,ko:K18478 ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100 - R00760,R00867,R01051,R02750,R03920,R10970 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_03197 658086.HMPREF0994_04560 2.98e-114 332.0 COG4126@1|root,COG4126@2|Bacteria,1UKAT@1239|Firmicutes 1239|Firmicutes E flavin adenine dinucleotide binding - - - - - - - - - - - - Asp_Glu_race KKPNOBBG_03198 658086.HMPREF0994_07095 8.21e-200 563.0 COG1680@1|root,COG1680@2|Bacteria,1UC2C@1239|Firmicutes,24B3Q@186801|Clostridia,27QDK@186928|unclassified Lachnospiraceae 186801|Clostridia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase KKPNOBBG_03199 658086.HMPREF0994_04564 1.77e-245 696.0 COG2972@1|root,COG2972@2|Bacteria,1UCQF@1239|Firmicutes,24EY1@186801|Clostridia 186801|Clostridia T signal transduction protein with a C-terminal ATPase domain - - - - - - - - - - - - His_kinase KKPNOBBG_03200 658086.HMPREF0994_04565 1.15e-237 667.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZKW@1239|Firmicutes,249VE@186801|Clostridia 186801|Clostridia T Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_03201 658086.HMPREF0994_04540 2.84e-304 842.0 arCOG07336@1|root,2Z8ST@2|Bacteria,1TRXN@1239|Firmicutes,248NM@186801|Clostridia,27IFW@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03202 33035.JPJF01000051_gene743 0.0 964.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,3Y1BM@572511|Blautia 186801|Clostridia M BCCT, betaine/carnitine/choline family transporter - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT KKPNOBBG_03203 33035.JPJF01000051_gene744 0.0 1321.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3Y0Z1@572511|Blautia 186801|Clostridia C Succinyl-CoA ligase like flavodoxin domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig KKPNOBBG_03204 33035.JPJF01000051_gene745 3.14e-121 346.0 COG1014@1|root,COG1014@2|Bacteria,1V39Q@1239|Firmicutes,24G9T@186801|Clostridia,3Y2CI@572511|Blautia 186801|Clostridia C Pyruvate ferredoxin/flavodoxin oxidoreductase - - - - - - - - - - - - POR KKPNOBBG_03205 33035.JPJF01000051_gene746 9.8e-178 494.0 COG1013@1|root,COG1013@2|Bacteria,1UY5M@1239|Firmicutes,25CAK@186801|Clostridia,3Y2CK@572511|Blautia 186801|Clostridia C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C KKPNOBBG_03206 33035.JPJF01000051_gene747 1.17e-249 685.0 COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3Y1C2@572511|Blautia 186801|Clostridia C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N KKPNOBBG_03207 33035.JPJF01000051_gene748 9.62e-34 116.0 COG2768@1|root,COG2768@2|Bacteria,1UI12@1239|Firmicutes,25EA0@186801|Clostridia,3Y262@572511|Blautia 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 KKPNOBBG_03208 33035.JPJF01000051_gene749 8.37e-265 729.0 COG2271@1|root,COG2271@2|Bacteria,1UZ2K@1239|Firmicutes,2493E@186801|Clostridia,3Y1Q1@572511|Blautia 186801|Clostridia G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_03209 33035.JPJF01000051_gene750 1.06e-279 764.0 COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,24AQM@186801|Clostridia 186801|Clostridia E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - - - - - - - - - - - ELFV_dehydrog,ELFV_dehydrog_N KKPNOBBG_03210 33035.JPJF01000051_gene751 3.35e-168 471.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,3XZSI@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_IclR,IclR KKPNOBBG_03211 33035.JPJF01000051_gene752 7.75e-43 141.0 COG1937@1|root,COG1937@2|Bacteria,1UGVX@1239|Firmicutes,25PGS@186801|Clostridia,3Y1WV@572511|Blautia 186801|Clostridia S Metal-sensitive transcriptional repressor - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal KKPNOBBG_03212 33035.JPJF01000051_gene753 2.55e-137 388.0 COG0693@1|root,COG0693@2|Bacteria,1V4K4@1239|Firmicutes,24C44@186801|Clostridia,3Y01T@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - DJ-1_PfpI KKPNOBBG_03213 33035.JPJF01000051_gene754 4.99e-145 410.0 COG1124@1|root,COG1124@2|Bacteria,1UYAV@1239|Firmicutes,24AEH@186801|Clostridia,3XZ01@572511|Blautia 186801|Clostridia EP ATPases associated with a variety of cellular activities - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran KKPNOBBG_03214 33035.JPJF01000051_gene755 1.26e-195 545.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3XZ0U@572511|Blautia 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY KKPNOBBG_03215 33035.JPJF01000051_gene756 2.19e-191 533.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZ8W@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_03216 33035.JPJF01000051_gene757 4.97e-225 621.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3XYJ3@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_03217 33035.JPJF01000051_gene758 0.0 1034.0 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,3XZDP@572511|Blautia 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_03218 1449126.JQKL01000023_gene212 5.52e-47 171.0 COG4126@1|root,COG4126@2|Bacteria,1TT35@1239|Firmicutes,24KAI@186801|Clostridia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - - ko:K14591 - - - - ko00000 - - - AroM KKPNOBBG_03219 33035.JPJF01000051_gene760 3.79e-177 495.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZYG@572511|Blautia 186801|Clostridia EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K13891 ko02010,map02010 M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.11 - - BPD_transp_1,OppC_N KKPNOBBG_03220 33035.JPJF01000051_gene761 1.41e-197 549.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3Y02S@572511|Blautia 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component gsiC_2 - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_03221 33035.JPJF01000051_gene762 0.0 989.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3Y1IS@572511|Blautia 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K13889 ko02010,map02010 M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.11 - - SBP_bac_5 KKPNOBBG_03222 33035.JPJF01000051_gene763 0.0 931.0 COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,3XYGK@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 KKPNOBBG_03223 33035.JPJF01000051_gene764 5.16e-272 751.0 COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,24BFZ@186801|Clostridia 186801|Clostridia S MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD KKPNOBBG_03224 33035.JPJF01000051_gene765 2.75e-219 606.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3XZ61@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_03225 33035.JPJF01000051_gene766 1.88e-225 622.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3XZ1P@572511|Blautia 186801|Clostridia EP Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02031,ko:K02032,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_03226 33035.JPJF01000051_gene767 3.21e-203 564.0 COG2207@1|root,COG2207@2|Bacteria,1V579@1239|Firmicutes,25B25@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_03227 33035.JPJF01000051_gene768 4.58e-141 399.0 COG1309@1|root,COG1309@2|Bacteria,1V7BK@1239|Firmicutes,24HI0@186801|Clostridia 186801|Clostridia K transcriptional regulator TetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03228 33035.JPJF01000051_gene769 1.26e-297 817.0 COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia 186801|Clostridia H PFAM Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_03229 33035.JPJF01000051_gene770 2.94e-258 711.0 COG2271@1|root,COG2271@2|Bacteria,1UZ2K@1239|Firmicutes,2493E@186801|Clostridia,3Y1NM@572511|Blautia 186801|Clostridia G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_03230 33035.JPJF01000051_gene771 0.0 903.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,3Y113@572511|Blautia 186801|Clostridia P Belongs to the BCCT transporter (TC 2.A.15) family - - - - - - - - - - - - BCCT KKPNOBBG_03235 180332.JTGN01000018_gene79 3.56e-143 429.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TRXY@1239|Firmicutes,24BYW@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_03236 180332.JTGN01000018_gene78 1.5e-172 510.0 COG2972@1|root,COG2972@2|Bacteria,1UYIY@1239|Firmicutes,24ACA@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_03237 180332.JTGN01000018_gene75 9.54e-207 585.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24C14@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03238 33035.JPJF01000051_gene772 6.46e-266 730.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,247ZP@186801|Clostridia,3Y0Z9@572511|Blautia 186801|Clostridia S Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_03239 33035.JPJF01000051_gene773 2.2e-115 330.0 COG0717@1|root,COG0717@2|Bacteria,1V1BE@1239|Firmicutes,24A3M@186801|Clostridia 186801|Clostridia F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - DCD,dUTPase KKPNOBBG_03240 97139.C824_00912 1.95e-127 382.0 COG1593@1|root,COG1593@2|Bacteria,1UIAS@1239|Firmicutes,25EFX@186801|Clostridia,36UPB@31979|Clostridiaceae 186801|Clostridia G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM KKPNOBBG_03241 395495.Lcho_0822 0.000831 47.0 COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,1MU0F@1224|Proteobacteria,2VHFG@28216|Betaproteobacteria,1KK5Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria G PFAM Tripartite ATP-independent periplasmic transporter DctQ component - - - - - - - - - - - - DctM,DctQ KKPNOBBG_03242 573413.Spirs_4174 4.75e-108 326.0 COG1638@1|root,COG1638@2|Bacteria,2J792@203691|Spirochaetes 203691|Spirochaetes G extracellular solute-binding protein, family 7 - - - ko:K21395 - - - - ko00000,ko02000 2.A.56.1 - - DctP KKPNOBBG_03243 1232453.BAIF02000003_gene1370 5.81e-109 331.0 COG3835@1|root,COG3835@2|Bacteria,1UYBM@1239|Firmicutes,249BJ@186801|Clostridia,26BED@186813|unclassified Clostridiales 186801|Clostridia KT Putative sugar diacid recognition - - - ko:K02647 - - - - ko00000,ko03000 - - - Diacid_rec,HTH_30 KKPNOBBG_03244 556261.HMPREF0240_03262 7.05e-169 485.0 COG0407@1|root,COG0407@2|Bacteria,1W13C@1239|Firmicutes,24Z3X@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_03245 1226325.HMPREF1548_01717 1.59e-39 140.0 2DBC6@1|root,2Z8BZ@2|Bacteria,1TQXM@1239|Firmicutes,2484N@186801|Clostridia,36I8F@31979|Clostridiaceae 186801|Clostridia S Replication initiator protein A (RepA) N-terminus - - - - - - - - - - - - RepA_N KKPNOBBG_03246 1226325.HMPREF1548_01681 0.0 870.0 COG2186@1|root,COG2188@1|root,COG2186@2|Bacteria,COG2188@2|Bacteria,1TSP3@1239|Firmicutes,24DQE@186801|Clostridia,36DRH@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, GntR family - - - - - - - - - - - - GntR KKPNOBBG_03247 1226325.HMPREF1548_01680 0.0 1004.0 COG2199@1|root,COG3437@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,36DPS@31979|Clostridiaceae 186801|Clostridia T domain protein rpfG3 - - ko:K07814 - - - - ko00000,ko02022 - - - GAF_2,GGDEF,HD,HD_5,Response_reg KKPNOBBG_03248 1226325.HMPREF1548_01679 5.19e-78 232.0 COG2198@1|root,COG2198@2|Bacteria,1VG8R@1239|Firmicutes,24QS0@186801|Clostridia 186801|Clostridia T Psort location Cytoplasmic, score - - - - - - - - - - - - Hpt KKPNOBBG_03249 742741.HMPREF9475_03505 0.0 1467.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,21YR0@1506553|Lachnoclostridium 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg KKPNOBBG_03250 1226325.HMPREF1548_01675 8.79e-38 133.0 COG1595@1|root,COG1595@2|Bacteria,1VW37@1239|Firmicutes,25AWT@186801|Clostridia 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r4_2 KKPNOBBG_03251 33035.JPJF01000051_gene775 0.0 2394.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3XYY2@572511|Blautia 186801|Clostridia F bifunctional enzyme phosphoribosylformylglycinamidine (FGAM) synthase (synthetase domain glutamine amidotransferase domain) purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 KKPNOBBG_03256 33035.JPJF01000051_gene776 7.2e-277 759.0 COG0738@1|root,COG0738@2|Bacteria,1TQPE@1239|Firmicutes,24AF8@186801|Clostridia,3XYNH@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MFS_1 KKPNOBBG_03257 33035.JPJF01000051_gene777 1.63e-200 556.0 COG0583@1|root,COG0583@2|Bacteria,1TRJK@1239|Firmicutes,24AY4@186801|Clostridia,3XZ9N@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_03258 33035.JPJF01000051_gene778 3.8e-153 433.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24A3N@186801|Clostridia,3XZ3G@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.49 - - - - - - - - - - - - ABC_tran KKPNOBBG_03259 33035.JPJF01000051_gene779 9.29e-159 448.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,24B9N@186801|Clostridia,3XZCY@572511|Blautia 186801|Clostridia P ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_03260 33035.JPJF01000051_gene780 0.0 932.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3XZGV@572511|Blautia 186801|Clostridia E Psort location Cellwall, score - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_03261 33035.JPJF01000051_gene781 1.03e-178 500.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZRV@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N KKPNOBBG_03262 33035.JPJF01000051_gene782 2.26e-200 558.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3XZG8@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_03263 33035.JPJF01000051_gene783 0.0 1019.0 COG0500@1|root,COG3608@1|root,COG2226@2|Bacteria,COG3608@2|Bacteria,1V3EF@1239|Firmicutes,24IK6@186801|Clostridia,3Y2A4@572511|Blautia 186801|Clostridia Q Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA,Methyltransf_11 KKPNOBBG_03264 33035.JPJF01000051_gene784 5.5e-165 463.0 COG0500@1|root,COG2226@2|Bacteria,1UY28@1239|Firmicutes,25KD5@186801|Clostridia,3Y089@572511|Blautia 186801|Clostridia Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 KKPNOBBG_03265 33035.JPJF01000051_gene785 1.07e-79 238.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,3Y05K@572511|Blautia 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP KKPNOBBG_03266 1423807.BACO01000036_gene1050 1.74e-138 406.0 COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,4HBTG@91061|Bacilli,3F94F@33958|Lactobacillaceae 91061|Bacilli S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA KKPNOBBG_03267 33035.JPJF01000051_gene786 2.93e-163 459.0 COG3622@1|root,COG3622@2|Bacteria,1V3V8@1239|Firmicutes,25C7T@186801|Clostridia 186801|Clostridia G Belongs to the hyi family - - 5.3.1.22 ko:K01816 ko00630,ko01100,map00630,map01100 - R01394 RC00511 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_03268 428125.CLOLEP_03153 1.04e-133 392.0 COG1063@1|root,COG1063@2|Bacteria,1TQKZ@1239|Firmicutes,24BU4@186801|Clostridia 186801|Clostridia E Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_zinc_N KKPNOBBG_03269 33035.JPJF01000072_gene4380 1.31e-22 107.0 COG1653@1|root,COG1653@2|Bacteria,1TT8P@1239|Firmicutes,24DVQ@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03270 545695.TREAZ_1656 1.52e-98 297.0 COG0395@1|root,COG0395@2|Bacteria,2JBHA@203691|Spirochaetes 203691|Spirochaetes P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03271 545695.TREAZ_1657 2.33e-99 301.0 COG1175@1|root,COG1175@2|Bacteria,2J6CI@203691|Spirochaetes 203691|Spirochaetes G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 KKPNOBBG_03272 545695.TREAZ_1658 8.14e-58 198.0 COG1609@1|root,COG1609@2|Bacteria,2J7P1@203691|Spirochaetes 203691|Spirochaetes K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529,ko:K05499 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_03274 33035.JPJF01000051_gene787 0.0 1474.0 COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,3XYZ7@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 dinG - 3.1.12.1,3.6.4.12 ko:K07464,ko:K10844 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400 - - - DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1 KKPNOBBG_03276 33035.JPJF01000051_gene788 2.2e-43 141.0 COG1925@1|root,COG1925@2|Bacteria,1VEJ5@1239|Firmicutes,24R2F@186801|Clostridia,3Y0M0@572511|Blautia 186801|Clostridia G phosphocarrier protein HPr - - - - - - - - - - - - PTS-HPr KKPNOBBG_03277 33035.JPJF01000051_gene789 4.13e-192 534.0 COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3XYU0@572511|Blautia 186801|Clostridia D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - - - - - - - - - - ParA KKPNOBBG_03278 33035.JPJF01000051_gene790 1.99e-68 208.0 COG1937@1|root,COG1937@2|Bacteria,1VA7S@1239|Firmicutes,24NNH@186801|Clostridia,3Y061@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal KKPNOBBG_03279 33035.JPJF01000051_gene791 1.27e-47 152.0 2ES6S@1|root,33JRI@2|Bacteria,1VQGH@1239|Firmicutes,24WUX@186801|Clostridia,3Y0HU@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_03280 411902.CLOBOL_03285 1.87e-242 673.0 COG2015@1|root,COG2015@2|Bacteria,1TR7Q@1239|Firmicutes,248SN@186801|Clostridia,2232Y@1506553|Lachnoclostridium 186801|Clostridia Q Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B KKPNOBBG_03281 411902.CLOBOL_03284 3.15e-123 355.0 COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,247U5@186801|Clostridia 186801|Clostridia E Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 KKPNOBBG_03282 33035.JPJF01000051_gene792 2.98e-129 367.0 COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,249VC@186801|Clostridia,3XZCM@572511|Blautia 186801|Clostridia F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis xpt - 2.4.2.22 ko:K03816 ko00230,ko01100,ko01110,map00230,map01100,map01110 - R01229,R02142 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran KKPNOBBG_03283 33035.JPJF01000051_gene793 4.66e-111 320.0 COG4720@1|root,COG4720@2|Bacteria,1VBJP@1239|Firmicutes,25CJQ@186801|Clostridia 186801|Clostridia S ECF-type riboflavin transporter, S component - - - - - - - - - - - - ECF-ribofla_trS KKPNOBBG_03284 33035.JPJF01000051_gene794 1.48e-99 289.0 COG0454@1|root,COG0456@2|Bacteria,1VDD6@1239|Firmicutes,24NEN@186801|Clostridia,3Y0NK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 KKPNOBBG_03285 33035.JPJF01000051_gene795 2.07e-36 123.0 29VFG@1|root,30GWP@2|Bacteria,1UGSZ@1239|Firmicutes,25PBW@186801|Clostridia,3Y25I@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03286 33035.JPJF01000051_gene796 9.85e-296 809.0 COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3XYYM@572511|Blautia 186801|Clostridia L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH KKPNOBBG_03287 33035.JPJF01000051_gene797 1.44e-276 757.0 COG1408@1|root,COG1408@2|Bacteria,1TS43@1239|Firmicutes,248XA@186801|Clostridia,3XZND@572511|Blautia 186801|Clostridia S Calcineurin-like phosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos KKPNOBBG_03288 411902.CLOBOL_01856 5.09e-173 494.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,21Z7G@1506553|Lachnoclostridium 186801|Clostridia E Cysteine desulfurase family protein - - - - - - - - - - - - Aminotran_5 KKPNOBBG_03289 33035.JPJF01000051_gene798 6.9e-220 610.0 COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,3XZ8H@572511|Blautia 186801|Clostridia H Synthesizes selenophosphate from selenide and ATP selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C KKPNOBBG_03290 33035.JPJF01000051_gene800 1.62e-179 499.0 COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,3XYR4@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 9.98 xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos KKPNOBBG_03291 33035.JPJF01000051_gene801 3.26e-111 320.0 COG3663@1|root,COG3663@2|Bacteria,1V6GI@1239|Firmicutes,24HD8@186801|Clostridia,3Y0AE@572511|Blautia 186801|Clostridia L Uracil DNA glycosylase superfamily - - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG KKPNOBBG_03292 33035.JPJF01000051_gene802 0.0 941.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3XYNA@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 purF_1 - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran KKPNOBBG_03293 33035.JPJF01000051_gene803 5.23e-154 435.0 COG1082@1|root,COG1082@2|Bacteria,1VFCG@1239|Firmicutes,24D46@186801|Clostridia,3Y01H@572511|Blautia 186801|Clostridia L Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03294 33035.JPJF01000051_gene804 7.15e-197 546.0 COG1284@1|root,COG1284@2|Bacteria,1TRBT@1239|Firmicutes,248B1@186801|Clostridia,3XYZS@572511|Blautia 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179,YitT_membrane KKPNOBBG_03295 33035.JPJF01000051_gene805 1.35e-237 653.0 COG1712@1|root,COG1712@2|Bacteria,1TQ4R@1239|Firmicutes,2499V@186801|Clostridia,3XYQU@572511|Blautia 186801|Clostridia E Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate ddh - 1.4.1.16 ko:K03340 ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230 M00526 R02755 RC00006 ko00000,ko00001,ko00002,ko01000 - - - DAPDH_C,DapB_N KKPNOBBG_03296 33035.JPJF01000051_gene806 6.6e-295 808.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3Y12F@572511|Blautia 186801|Clostridia S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF KKPNOBBG_03297 658086.HMPREF0994_01132 7.65e-168 474.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia,27JW4@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03298 658086.HMPREF0994_01133 1.33e-192 538.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,27INJ@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03299 658086.HMPREF0994_01134 9.05e-231 649.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24YHB@186801|Clostridia 186801|Clostridia G Domain of unknown function (DUF3502) - - - - - - - - - - - - DUF3502,SBP_bac_1 KKPNOBBG_03300 658086.HMPREF0994_01143 3.73e-153 447.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,24FD5@186801|Clostridia,27MYJ@186928|unclassified Lachnospiraceae 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_03301 658086.HMPREF0994_01144 1.4e-116 359.0 COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,24CTB@186801|Clostridia,27NM0@186928|unclassified Lachnospiraceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - His_kinase KKPNOBBG_03302 33035.JPJF01000015_gene4979 0.0 1151.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XZXF@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_03303 180332.JTGN01000001_gene5100 4.38e-166 496.0 COG3408@1|root,COG3408@2|Bacteria,1TSSU@1239|Firmicutes,24BK6@186801|Clostridia 186801|Clostridia G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - - - - - - - - - - Bac_rhamnosid6H KKPNOBBG_03305 1304866.K413DRAFT_3623 4.78e-123 360.0 COG0524@1|root,COG0524@2|Bacteria,1UZ37@1239|Firmicutes,24C7B@186801|Clostridia,36HDW@31979|Clostridiaceae 186801|Clostridia G pfkB family carbohydrate kinase - - 2.7.1.20,2.7.1.213,2.7.1.73 ko:K00856,ko:K22026 ko00230,ko00240,ko01100,map00230,map00240,map01100 - R00185,R00513,R01131,R01228 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_03306 1304866.K413DRAFT_3624 4.18e-243 677.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,36EXF@31979|Clostridiaceae 186801|Clostridia G family 4 - - 3.2.1.86 ko:K01222 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_03307 1304866.K413DRAFT_3625 1.04e-146 420.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,36FAY@31979|Clostridiaceae 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03308 1304866.K413DRAFT_3626 5.58e-227 635.0 COG1653@1|root,COG1653@2|Bacteria,1TR0C@1239|Firmicutes,248RD@186801|Clostridia,36E9E@31979|Clostridiaceae 186801|Clostridia G PFAM Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 KKPNOBBG_03309 585501.HMPREF6123_1769 8.91e-122 356.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia,2PTHC@265975|Oribacterium 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03310 180332.JTGN01000017_gene174 1.16e-133 390.0 COG1609@1|root,COG1609@2|Bacteria,1TSDP@1239|Firmicutes,24E9C@186801|Clostridia 186801|Clostridia K Periplasmic binding protein-like domain - - - - - - - - - - - - LacI,Peripla_BP_3 KKPNOBBG_03311 33035.JPJF01000051_gene816 5.62e-252 691.0 COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,3XYNV@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_03312 33035.JPJF01000051_gene817 3.36e-293 799.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3XYNE@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas KKPNOBBG_03313 33035.JPJF01000051_gene818 1.34e-166 466.0 COG3363@1|root,COG3363@2|Bacteria,1TRA7@1239|Firmicutes,249ZW@186801|Clostridia,3XZ1G@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - IMP_cyclohyd KKPNOBBG_03314 33035.JPJF01000051_gene821 1.97e-275 754.0 COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,3XZRE@572511|Blautia 186801|Clostridia J Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM,PUA KKPNOBBG_03315 33035.JPJF01000051_gene822 5.91e-154 438.0 COG1476@1|root,COG1476@2|Bacteria,1V7I5@1239|Firmicutes,24KRY@186801|Clostridia,3Y0HW@572511|Blautia 186801|Clostridia K Psort location - - - - - - - - - - - - HTH_3 KKPNOBBG_03316 1280689.AUJC01000001_gene2021 0.0 1054.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_03317 1280698.AUJS01000065_gene660 2.27e-288 788.0 COG3620@1|root,COG3620@2|Bacteria,1TPHQ@1239|Firmicutes,249PB@186801|Clostridia,27XDR@189330|Dorea 186801|Clostridia K Replication initiation factor - - - - - - - - - - - - HTH_3,Rep_trans KKPNOBBG_03318 476272.RUMHYD_01375 5.47e-66 202.0 2CHUG@1|root,347UY@2|Bacteria,1W1EI@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_03319 500632.CLONEX_02437 8.38e-120 342.0 28JZX@1|root,33IWH@2|Bacteria,1VQFM@1239|Firmicutes,2529A@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03321 33035.JPJF01000051_gene822 2.21e-15 74.3 COG1476@1|root,COG1476@2|Bacteria,1V7I5@1239|Firmicutes,24KRY@186801|Clostridia,3Y0HW@572511|Blautia 186801|Clostridia K Psort location - - - - - - - - - - - - HTH_3 KKPNOBBG_03322 33035.JPJF01000051_gene823 4.84e-121 347.0 COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia 186801|Clostridia E Psort location Cytoplasmic, score - - - ko:K07043 - - - - ko00000 - - - DUF45 KKPNOBBG_03323 537007.BLAHAN_06778 1.57e-169 478.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3XZRD@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24,SEC-C KKPNOBBG_03324 33035.JPJF01000114_gene2277 1.07e-136 389.0 COG2755@1|root,COG2755@2|Bacteria,1V49F@1239|Firmicutes,24D1K@186801|Clostridia,3Y0I8@572511|Blautia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_03325 33035.JPJF01000114_gene2278 6.21e-111 320.0 COG1670@1|root,COG1670@2|Bacteria,1V4IY@1239|Firmicutes,24FWK@186801|Clostridia 186801|Clostridia J guanosine monophosphate synthetase GuaA K01951 guaA3 - - - - - - - - - - - Acetyltransf_3,DUF3795 KKPNOBBG_03326 33035.JPJF01000114_gene2279 2.16e-101 295.0 COG0454@1|root,COG0456@2|Bacteria,1V6Z8@1239|Firmicutes,24JT6@186801|Clostridia,3Y06X@572511|Blautia 186801|Clostridia K COG COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_03327 33035.JPJF01000114_gene2280 4.58e-146 410.0 COG1592@1|root,COG1592@2|Bacteria,1V05U@1239|Firmicutes,24BTY@186801|Clostridia,3Y015@572511|Blautia 186801|Clostridia C Rubrerythrin rbr1 - - - - - - - - - - - Rubrerythrin KKPNOBBG_03328 33035.JPJF01000114_gene2281 5.07e-134 382.0 COG1102@1|root,COG1102@2|Bacteria,1V79E@1239|Firmicutes,24GMW@186801|Clostridia,3XZZJ@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_03329 33035.JPJF01000114_gene2282 5.01e-303 832.0 COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1TR1R@1239|Firmicutes,24A67@186801|Clostridia,3XZJX@572511|Blautia 186801|Clostridia CE Rieske [2Fe-2S] domain - - - - - - - - - - - - DAO,Rieske KKPNOBBG_03330 33035.JPJF01000114_gene2283 1.31e-99 289.0 COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,3XZZW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - MOSC,MoCF_biosynth KKPNOBBG_03331 33035.JPJF01000114_gene2284 2.57e-225 622.0 COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,3XZDJ@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM KKPNOBBG_03332 33035.JPJF01000114_gene2285 2.56e-111 321.0 COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3XZBD@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Rubrerythrin KKPNOBBG_03333 33035.JPJF01000114_gene2286 1.47e-68 207.0 COG2315@1|root,COG2315@2|Bacteria,1VVT6@1239|Firmicutes,25EAU@186801|Clostridia,3Y0FV@572511|Blautia 186801|Clostridia L YjbR ogt - - - - - - - - - - - DNA_binding_1,YjbR KKPNOBBG_03334 33035.JPJF01000114_gene2287 0.0 929.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3XZCN@572511|Blautia 186801|Clostridia H COG COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N KKPNOBBG_03335 33035.JPJF01000086_gene907 8.19e-108 311.0 COG0440@1|root,COG0440@2|Bacteria,1V3PG@1239|Firmicutes,24A0D@186801|Clostridia,3XZ1J@572511|Blautia 186801|Clostridia E COG COG0440 Acetolactate synthase, small (regulatory) subunit ilvH_1 - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C KKPNOBBG_03336 33035.JPJF01000086_gene908 0.0 1300.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1U78Z@1239|Firmicutes,24NZ8@186801|Clostridia,3Y14E@572511|Blautia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS_3 KKPNOBBG_03340 553973.CLOHYLEM_05166 9.79e-36 126.0 2BWQV@1|root,346D0@2|Bacteria,1VZMB@1239|Firmicutes,24S93@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03341 553973.CLOHYLEM_05165 4.14e-22 87.0 28URH@1|root,2ZGVT@2|Bacteria,1W5TU@1239|Firmicutes,24VG4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03342 33035.JPJF01000086_gene922 0.0 1459.0 COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,3XYPB@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 tvaI - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Alpha-amylase_N KKPNOBBG_03343 33035.JPJF01000086_gene923 0.0 1159.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,3XYI4@572511|Blautia 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 KKPNOBBG_03344 33035.JPJF01000086_gene924 2.61e-117 336.0 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,3XZH4@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 9.98 hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran KKPNOBBG_03345 33035.JPJF01000086_gene925 6.99e-284 781.0 COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,3XZQI@572511|Blautia 186801|Clostridia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C KKPNOBBG_03346 33035.JPJF01000086_gene926 0.0 966.0 COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia,3XYWW@572511|Blautia 186801|Clostridia KT Psort location Cytoplasmic, score 8.87 spoIIE - 3.1.3.16 ko:K06382 - - - - ko00000,ko01000 - - - SpoIIE KKPNOBBG_03347 33035.JPJF01000086_gene927 4.87e-36 124.0 COG2919@1|root,COG2919@2|Bacteria,1VGPP@1239|Firmicutes,24R6M@186801|Clostridia,3Y0KS@572511|Blautia 186801|Clostridia D Septum formation initiator - - - - - - - - - - - - DivIC KKPNOBBG_03348 33035.JPJF01000086_gene928 3.32e-100 291.0 2EFTM@1|root,32YR5@2|Bacteria,1VEV2@1239|Firmicutes,25JHW@186801|Clostridia,3Y0V0@572511|Blautia 186801|Clostridia S Spore cortex protein YabQ (Spore_YabQ) - - - - - - - - - - - - Spore_YabQ KKPNOBBG_03349 33035.JPJF01000086_gene929 5.43e-57 177.0 2E3ZZ@1|root,32YWW@2|Bacteria,1VEIW@1239|Firmicutes,24QNQ@186801|Clostridia,3Y0MV@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yabP - - - - - - - - - - - YabP KKPNOBBG_03350 33035.JPJF01000086_gene930 4.8e-46 148.0 COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,3Y0D7@572511|Blautia 186801|Clostridia J COG COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) hslR - - - - - - - - - - - S4 KKPNOBBG_03351 33035.JPJF01000086_gene931 6.27e-52 164.0 COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,3Y0HQ@572511|Blautia 186801|Clostridia L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hup - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding KKPNOBBG_03352 33035.JPJF01000086_gene932 0.0 1121.0 COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,3XYJR@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 pgcA - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV KKPNOBBG_03353 33035.JPJF01000086_gene933 1.29e-233 642.0 COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia,3XYQZ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 cotS - - ko:K06331,ko:K06337 - - - - ko00000 - - - APH,Choline_kinase KKPNOBBG_03355 33035.JPJF01000022_gene3289 2.51e-285 783.0 COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,3XZRW@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 cca - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2 KKPNOBBG_03356 33035.JPJF01000022_gene3290 0.0 959.0 COG0441@1|root,COG0441@2|Bacteria,1UHT4@1239|Firmicutes,25E98@186801|Clostridia,3XZ9B@572511|Blautia 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b KKPNOBBG_03357 33035.JPJF01000022_gene3291 1.43e-115 330.0 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,3XZHH@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 KKPNOBBG_03358 33035.JPJF01000022_gene3292 1.66e-143 405.0 COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,3XZJ9@572511|Blautia 186801|Clostridia F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase KKPNOBBG_03359 33035.JPJF01000022_gene3293 4.29e-101 292.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3XZXS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB KKPNOBBG_03360 33035.JPJF01000022_gene3294 5.8e-229 633.0 COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,3XZ73@572511|Blautia 186801|Clostridia H Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC KKPNOBBG_03361 33035.JPJF01000022_gene3295 6e-151 426.0 COG0860@1|root,COG0860@2|Bacteria,1TQ74@1239|Firmicutes,24FT2@186801|Clostridia,3XZTY@572511|Blautia 186801|Clostridia M N-acetylmuramoyl-L-alanine amidase cwlD - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 KKPNOBBG_03362 33035.JPJF01000022_gene3296 0.0 1325.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3Y1FR@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3 KKPNOBBG_03363 33035.JPJF01000022_gene3297 2.03e-124 361.0 2D9P4@1|root,32TTM@2|Bacteria,1VCY3@1239|Firmicutes,24NB7@186801|Clostridia,3Y08U@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03364 33035.JPJF01000022_gene3298 0.0 1022.0 COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,3XZGJ@572511|Blautia 186801|Clostridia S Glyco_18 ydhD - - - - - - - - - - - CW_binding_2,Cu_amine_oxidN1,Glyco_hydro_18,SH3_3 KKPNOBBG_03365 33035.JPJF01000022_gene3299 2.72e-41 138.0 2EHIK@1|root,32JCB@2|Bacteria,1UQK2@1239|Firmicutes,258C2@186801|Clostridia,3Y0SM@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03366 33035.JPJF01000022_gene3300 1.88e-167 469.0 COG4862@1|root,COG4862@2|Bacteria,1UZ7D@1239|Firmicutes,24BWV@186801|Clostridia,3XZPB@572511|Blautia 186801|Clostridia NOT COG COG4862 Negative regulator of genetic competence, sporulation and motility mecB - - ko:K16511 - - - - ko00000 - - - MecA KKPNOBBG_03367 33035.JPJF01000022_gene3301 9.99e-40 131.0 COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia,3Y0MQ@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF1858 KKPNOBBG_03368 33035.JPJF01000022_gene3302 6.88e-18 75.9 COG1148@1|root,COG1148@2|Bacteria,1UI0M@1239|Firmicutes,25E99@186801|Clostridia,3Y0Q0@572511|Blautia 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 KKPNOBBG_03369 33035.JPJF01000022_gene3303 2.32e-100 298.0 COG0789@1|root,COG0789@2|Bacteria,1V4F1@1239|Firmicutes,24NFY@186801|Clostridia,3Y0KV@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - MerR_1 KKPNOBBG_03370 33035.JPJF01000022_gene3304 5.37e-174 486.0 COG1028@1|root,COG1028@2|Bacteria,1TSBE@1239|Firmicutes,24BPX@186801|Clostridia 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 KKPNOBBG_03371 33035.JPJF01000022_gene3307 1.23e-247 684.0 COG1454@1|root,COG1454@2|Bacteria,1UY3E@1239|Firmicutes,25E9A@186801|Clostridia,3Y1KX@572511|Blautia 186801|Clostridia C Iron-containing alcohol dehydrogenase - - 1.1.1.1 ko:K13954 ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R04880,R05233,R05234,R06917,R06927 RC00050,RC00088,RC00099,RC00116,RC00649 ko00000,ko00001,ko01000 - - - Fe-ADH KKPNOBBG_03372 33035.JPJF01000022_gene3308 0.0 1009.0 COG3669@1|root,COG3669@2|Bacteria,1U9XH@1239|Firmicutes,24DER@186801|Clostridia 186801|Clostridia G Alpha-L-fucosidase - - - - - - - - - - - - Alpha_L_fucos KKPNOBBG_03373 33035.JPJF01000022_gene3309 6.12e-129 371.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3XZXP@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03374 33035.JPJF01000022_gene3310 5.58e-184 513.0 COG1175@1|root,COG1175@2|Bacteria,1TRP6@1239|Firmicutes,24YGY@186801|Clostridia,3Y047@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03375 33035.JPJF01000022_gene3311 2.13e-299 821.0 COG1653@1|root,COG1653@2|Bacteria,1UZ95@1239|Firmicutes,24CZU@186801|Clostridia,3Y01G@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03376 33035.JPJF01000022_gene3312 5e-270 741.0 COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK KKPNOBBG_03377 33035.JPJF01000022_gene3313 1.36e-251 694.0 COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3XYHF@572511|Blautia 186801|Clostridia GK Psort location Cytoplasmic, score - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK KKPNOBBG_03378 33035.JPJF01000022_gene3314 1.49e-93 273.0 COG3238@1|root,COG3238@2|Bacteria,1V6J0@1239|Firmicutes,24JM9@186801|Clostridia,3Y03G@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ KKPNOBBG_03379 33035.JPJF01000022_gene3315 1.19e-278 763.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,3XYZW@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 KKPNOBBG_03380 33035.JPJF01000022_gene3316 1.85e-209 579.0 COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,3XZI8@572511|Blautia 186801|Clostridia E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase KKPNOBBG_03381 33035.JPJF01000022_gene3317 2.47e-273 750.0 COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,3XZ0G@572511|Blautia 186801|Clostridia E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ KKPNOBBG_03382 33035.JPJF01000022_gene3318 5.8e-248 681.0 COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,3XZMQ@572511|Blautia 186801|Clostridia E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC KKPNOBBG_03383 33035.JPJF01000022_gene3319 1.35e-303 827.0 COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,3XYUF@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth KKPNOBBG_03384 658086.HMPREF0994_01799 1.33e-99 299.0 COG5464@1|root,COG5464@2|Bacteria,1TYDT@1239|Firmicutes,24EGK@186801|Clostridia,27TQ3@186928|unclassified Lachnospiraceae 186801|Clostridia S PD-(D/E)XK nuclease family transposase - - - - - - - - - - - - DUF4351,HTH_7,PDDEXK_2 KKPNOBBG_03385 658086.HMPREF0994_06178 1.01e-224 631.0 COG3290@1|root,COG3290@2|Bacteria,1VC62@1239|Firmicutes,25FKE@186801|Clostridia,27U05@186928|unclassified Lachnospiraceae 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_03386 33035.JPJF01000022_gene3320 0.0 1562.0 COG0695@1|root,COG1328@1|root,COG0695@2|Bacteria,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,3XZ7A@572511|Blautia 186801|Clostridia FO Psort location Cytoplasmic, score 8.87 nrdD - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,Glutaredoxin,NRDD KKPNOBBG_03387 33035.JPJF01000022_gene3321 3.09e-270 743.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,3XZ8M@572511|Blautia 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 KKPNOBBG_03389 33035.JPJF01000022_gene3323 6.44e-183 512.0 COG1131@1|root,COG1131@2|Bacteria,1TPZR@1239|Firmicutes,247NW@186801|Clostridia,3Y11Y@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03390 33035.JPJF01000022_gene3324 2.92e-76 228.0 COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,3Y08N@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_03391 33035.JPJF01000022_gene3325 0.0 1218.0 COG3387@1|root,COG3387@2|Bacteria,1UI0N@1239|Firmicutes,25DI4@186801|Clostridia 186801|Clostridia G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_N KKPNOBBG_03392 33035.JPJF01000028_gene2749 0.0 1003.0 COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,3Y0AT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_03393 33035.JPJF01000028_gene2750 1.79e-172 483.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,3XZDV@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03394 33035.JPJF01000028_gene2751 2.06e-205 573.0 COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,3Y000@572511|Blautia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_03395 33035.JPJF01000028_gene2752 1.93e-138 393.0 COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,3Y06R@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03396 33035.JPJF01000028_gene2755 5.43e-221 612.0 COG0457@1|root,COG0457@2|Bacteria,1V4J9@1239|Firmicutes,24VUT@186801|Clostridia,3XYS1@572511|Blautia 186801|Clostridia S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_8 KKPNOBBG_03397 33035.JPJF01000028_gene2756 0.0 877.0 COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,3XYSV@572511|Blautia 186801|Clostridia G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV KKPNOBBG_03398 33035.JPJF01000028_gene2757 2.4e-204 567.0 COG1209@1|root,COG1209@2|Bacteria,1TPR2@1239|Firmicutes,2490F@186801|Clostridia,3XYIA@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - NTP_transferase KKPNOBBG_03399 33035.JPJF01000028_gene2758 2.32e-234 645.0 COG0407@1|root,COG0407@2|Bacteria,1V5JE@1239|Firmicutes,24J5K@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_03400 33035.JPJF01000028_gene2759 4.05e-180 503.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03401 33035.JPJF01000028_gene2760 1.2e-203 565.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XYIT@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03402 33035.JPJF01000028_gene2761 8.04e-269 740.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03403 33035.JPJF01000028_gene2762 0.0 956.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,25B1H@186801|Clostridia,3Y2A1@572511|Blautia 186801|Clostridia KT Helix-turn-helix domain - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_03404 33035.JPJF01000028_gene2763 0.0 895.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3Y1P8@572511|Blautia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_03405 33035.JPJF01000028_gene2764 1.37e-247 681.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3XYXD@572511|Blautia 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 KKPNOBBG_03406 33035.JPJF01000028_gene2765 1.37e-174 490.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,3XZ9I@572511|Blautia 186801|Clostridia J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 KKPNOBBG_03407 33035.JPJF01000028_gene2766 7.45e-220 610.0 COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,3XYUQ@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score prmC - - - - - - - - - - - DUF1385,MTS KKPNOBBG_03408 537007.BLAHAN_06295 3.3e-43 140.0 COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3Y0G4@572511|Blautia 186801|Clostridia J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 KKPNOBBG_03409 33035.JPJF01000028_gene2767 4.77e-306 840.0 COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,3XZ4R@572511|Blautia 186801|Clostridia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind KKPNOBBG_03410 33035.JPJF01000028_gene2768 4.51e-79 235.0 COG0346@1|root,COG0346@2|Bacteria,1V6K3@1239|Firmicutes,24J94@186801|Clostridia,3Y06G@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 gloA - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase KKPNOBBG_03411 33035.JPJF01000028_gene2769 0.0 905.0 COG1219@1|root,COG1219@2|Bacteria,1TPDI@1239|Firmicutes,24AEG@186801|Clostridia,3XYQ7@572511|Blautia 186801|Clostridia O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX_1 - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX KKPNOBBG_03412 33035.JPJF01000028_gene2770 0.0 891.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3XZRU@572511|Blautia 186801|Clostridia O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 KKPNOBBG_03413 33035.JPJF01000028_gene2771 0.0 1174.0 COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,3XZNF@572511|Blautia 186801|Clostridia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS KKPNOBBG_03414 33035.JPJF01000028_gene2772 8.16e-213 588.0 COG1216@1|root,COG1216@2|Bacteria,1TSXW@1239|Firmicutes,2499G@186801|Clostridia,3XZN2@572511|Blautia 186801|Clostridia S LPS side chain defect rhamnosyl transferase - - - ko:K12992 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 KKPNOBBG_03415 33035.JPJF01000028_gene2773 5.84e-249 696.0 COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,248RH@186801|Clostridia,3XYM4@572511|Blautia 186801|Clostridia K COG COG1316 Transcriptional regulator - - - - - - - - - - - - LytR_cpsA_psr KKPNOBBG_03416 33035.JPJF01000028_gene2774 0.0 916.0 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,248WV@186801|Clostridia,3XZDD@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score - - 2.7.8.6 ko:K00996 - - - - ko00000,ko01000,ko01005 - - - Bac_transf,CoA_binding_3 KKPNOBBG_03417 33035.JPJF01000028_gene2775 9.39e-106 307.0 COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,3XZNC@572511|Blautia 186801|Clostridia H Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CM_2,SKI KKPNOBBG_03418 33035.JPJF01000028_gene2776 2.22e-298 817.0 COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,3Y1PW@572511|Blautia 186801|Clostridia C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain merA - 1.16.1.1 ko:K00520 - - - - ko00000,ko01000 - - - Pyr_redox_2,Pyr_redox_dim KKPNOBBG_03419 33035.JPJF01000028_gene2777 8.71e-85 251.0 COG1959@1|root,COG1959@2|Bacteria,1W6XJ@1239|Firmicutes,24SDU@186801|Clostridia,3Y0UG@572511|Blautia 186801|Clostridia K Winged helix-turn-helix transcription repressor, HrcA DNA-binding - - - - - - - - - - - - Rrf2 KKPNOBBG_03420 33035.JPJF01000028_gene2778 1.43e-183 513.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,3XZBQ@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Fer4,Fer4_5 KKPNOBBG_03421 33035.JPJF01000028_gene2779 4.94e-19 78.2 2EHC1@1|root,33B3W@2|Bacteria,1VMYX@1239|Firmicutes,24UJJ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03422 33035.JPJF01000028_gene2780 1.67e-109 322.0 COG0526@1|root,COG0526@2|Bacteria,1VADU@1239|Firmicutes,25B1J@186801|Clostridia 186801|Clostridia CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin KKPNOBBG_03423 33035.JPJF01000028_gene2781 1.19e-233 644.0 COG1063@1|root,COG1063@2|Bacteria,1UUV0@1239|Firmicutes,25MAN@186801|Clostridia,3Y1TA@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_03424 33035.JPJF01000028_gene2782 3.68e-218 608.0 COG1940@1|root,COG1940@2|Bacteria,1TRT1@1239|Firmicutes,24A9E@186801|Clostridia,3Y11N@572511|Blautia 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK KKPNOBBG_03425 33035.JPJF01000028_gene2783 0.0 930.0 COG2199@1|root,COG2199@2|Bacteria,1V8BN@1239|Firmicutes,25B1K@186801|Clostridia,3Y2DV@572511|Blautia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF KKPNOBBG_03426 33035.JPJF01000028_gene2784 7.56e-227 628.0 COG3568@1|root,COG3568@2|Bacteria,1U5BI@1239|Firmicutes,24A34@186801|Clostridia,3Y02W@572511|Blautia 186801|Clostridia S Endonuclease exonuclease phosphatase family protein - - - - - - - - - - - - Exo_endo_phos KKPNOBBG_03428 457421.CBFG_01074 7.62e-177 511.0 COG2186@1|root,COG2186@2|Bacteria,1U60C@1239|Firmicutes,25FSW@186801|Clostridia 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_03429 411490.ANACAC_01642 0.0 1127.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9,Response_reg KKPNOBBG_03430 33035.JPJF01000028_gene2790 7.08e-136 387.0 COG0664@1|root,COG0664@2|Bacteria,1V39R@1239|Firmicutes,24C2I@186801|Clostridia,3XZTI@572511|Blautia 186801|Clostridia T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding KKPNOBBG_03432 180332.JTGN01000005_gene3013 7.74e-246 684.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_03433 33035.JPJF01000028_gene2792 0.0 911.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_03434 33035.JPJF01000028_gene2793 8.95e-176 491.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short,adh_short_C2 KKPNOBBG_03435 33035.JPJF01000028_gene2794 7.17e-242 667.0 COG1940@1|root,COG1940@2|Bacteria,1TRT1@1239|Firmicutes,24A9E@186801|Clostridia,3XZW7@572511|Blautia 186801|Clostridia GK ROK family - - - - - - - - - - - - HTH_24,ROK KKPNOBBG_03436 33035.JPJF01000028_gene2795 7.92e-189 528.0 COG1533@1|root,COG1533@2|Bacteria,1TQA6@1239|Firmicutes,24A2T@186801|Clostridia,3Y02D@572511|Blautia 186801|Clostridia L Domain of unknown function (DUF1848) - - - - - - - - - - - - DUF1848 KKPNOBBG_03437 33035.JPJF01000028_gene2796 0.0 1293.0 COG1653@1|root,COG1653@2|Bacteria,1TPM0@1239|Firmicutes,24ARZ@186801|Clostridia 186801|Clostridia G Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF1565 KKPNOBBG_03438 33035.JPJF01000028_gene2797 0.0 1516.0 COG2203@1|root,COG3850@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3850@2|Bacteria,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3XZE8@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GAF,GGDEF KKPNOBBG_03439 33035.JPJF01000028_gene2798 8.75e-154 436.0 28K3V@1|root,2Z9SY@2|Bacteria,1V0NZ@1239|Firmicutes,24EEF@186801|Clostridia 186801|Clostridia S EcsC protein family - - - - - - - - - - - - EcsC KKPNOBBG_03440 33035.JPJF01000028_gene2799 0.0 1070.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3XZD3@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C KKPNOBBG_03441 33035.JPJF01000028_gene2800 0.0 1587.0 COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes 1239|Firmicutes L COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine yprA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C KKPNOBBG_03442 33035.JPJF01000028_gene2801 7.4e-114 329.0 COG1309@1|root,COG1309@2|Bacteria,1UUV1@1239|Firmicutes,2585K@186801|Clostridia,3Y1RA@572511|Blautia 186801|Clostridia K WHG domain - - - - - - - - - - - - WHG KKPNOBBG_03443 33035.JPJF01000028_gene2802 1.59e-146 414.0 COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,3Y11K@572511|Blautia 186801|Clostridia V ABC transporter - - - - - - - - - - - - ABC_tran KKPNOBBG_03444 33035.JPJF01000028_gene2803 2.27e-227 632.0 28K0P@1|root,2Z9QJ@2|Bacteria,1TSN2@1239|Firmicutes,24YHY@186801|Clostridia 186801|Clostridia P FtsX-like permease family - - - - - - - - - - - - FtsX KKPNOBBG_03445 33035.JPJF01000028_gene2804 1.42e-161 456.0 COG1237@1|root,COG1237@2|Bacteria,1UWI6@1239|Firmicutes,247K3@186801|Clostridia,3Y1XS@572511|Blautia 186801|Clostridia S Metallo-beta-lactamase superfamily - - 2.5.1.105 ko:K06897 ko00790,map00790 - R10339 RC00121 ko00000,ko00001,ko01000 - - - Lactamase_B KKPNOBBG_03446 33035.JPJF01000028_gene2805 1.89e-166 468.0 COG0789@1|root,COG0789@2|Bacteria,1UUV2@1239|Firmicutes,25M6G@186801|Clostridia,3Y269@572511|Blautia 186801|Clostridia K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 KKPNOBBG_03447 33035.JPJF01000028_gene2806 1.9e-97 285.0 COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,247X5@186801|Clostridia 186801|Clostridia Q Methyltransferase, YaeB - - - - - - - - - - - - UPF0066 KKPNOBBG_03448 33035.JPJF01000028_gene2807 1.01e-94 276.0 COG4154@1|root,COG4154@2|Bacteria,1V402@1239|Firmicutes,24FU7@186801|Clostridia,3XZZ7@572511|Blautia 186801|Clostridia G RbsD / FucU transport protein family fucU - 5.1.3.29 ko:K02431 - - R10764 RC00563 ko00000,ko01000 - - - RbsD_FucU KKPNOBBG_03449 33035.JPJF01000028_gene2808 1.14e-160 450.0 COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,3XZRB@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 fucA - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II KKPNOBBG_03450 33035.JPJF01000028_gene2809 0.0 930.0 COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,3XYXG@572511|Blautia 186801|Clostridia G FGGY family of carbohydrate kinases, C-terminal domain rhaB - 2.7.1.5,2.7.1.51 ko:K00848,ko:K00879 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014,R03241 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_03451 33035.JPJF01000028_gene2810 0.0 1197.0 COG2407@1|root,COG2407@2|Bacteria,1TQ5Q@1239|Firmicutes,248V0@186801|Clostridia,3XZ8N@572511|Blautia 186801|Clostridia G Converts the aldose L-fucose into the corresponding ketose L-fuculose fucI - 5.3.1.25,5.3.1.3 ko:K01818 ko00051,ko01120,map00051,map01120 - R03163 RC00434 ko00000,ko00001,ko01000 - - - Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2 KKPNOBBG_03452 33035.JPJF01000028_gene2811 2.8e-195 542.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1V1UE@1239|Firmicutes,24AK4@186801|Clostridia,3XZ87@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_03453 33035.JPJF01000028_gene2812 0.0 932.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia,3XZQH@572511|Blautia 186801|Clostridia I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding KKPNOBBG_03454 33035.JPJF01000028_gene2813 2.77e-41 136.0 COG0236@1|root,COG0236@2|Bacteria,1VG07@1239|Firmicutes,25E9I@186801|Clostridia 186801|Clostridia IQ Phosphopantetheine attachment site - - - - - - - - - - - - PP-binding KKPNOBBG_03455 33035.JPJF01000028_gene2814 0.0 909.0 COG1020@1|root,COG1020@2|Bacteria,1TQP2@1239|Firmicutes,24AMK@186801|Clostridia,3Y0AJ@572511|Blautia 186801|Clostridia Q Condensation domain - - - - - - - - - - - - Condensation KKPNOBBG_03456 33035.JPJF01000028_gene2815 1.76e-234 646.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3Y086@572511|Blautia 186801|Clostridia S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - FSH1,Hydrolase_4,Peptidase_S9 KKPNOBBG_03457 33035.JPJF01000028_gene2816 5.94e-66 204.0 2DWDV@1|root,32V1D@2|Bacteria,1VAUV@1239|Firmicutes,24NQH@186801|Clostridia 186801|Clostridia S SCP-2 sterol transfer family - - - - - - - - - - - - SCP2 KKPNOBBG_03458 33035.JPJF01000028_gene2817 1.66e-126 361.0 COG1309@1|root,COG1309@2|Bacteria,1V09H@1239|Firmicutes,25B1M@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03459 33035.JPJF01000028_gene2818 1.43e-133 386.0 COG0500@1|root,COG2226@2|Bacteria,1TQEA@1239|Firmicutes,24HII@186801|Clostridia 186801|Clostridia Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 KKPNOBBG_03460 33035.JPJF01000028_gene2819 0.0 872.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,3XZU5@572511|Blautia 186801|Clostridia G COG COG2211 Na melibiose symporter and related transporters gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_03461 33035.JPJF01000028_gene2820 4.82e-182 507.0 COG3622@1|root,COG3622@2|Bacteria,1TRQV@1239|Firmicutes,24AGD@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03462 33035.JPJF01000028_gene2821 6.92e-236 649.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,24B6F@186801|Clostridia 186801|Clostridia E Oxidoreductase NAD-binding domain protein - - 1.1.1.18,1.1.1.369 ko:K00010 ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130 - R01183,R09951 RC00182 ko00000,ko00001,ko01000 - - - Cupin_5,GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03464 33035.JPJF01000028_gene2822 1.11e-232 642.0 COG1879@1|root,COG1879@2|Bacteria,1UIZ0@1239|Firmicutes,24E8M@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - - - - - - - - - - LacI,Peripla_BP_4 KKPNOBBG_03465 33035.JPJF01000001_gene2575 8.92e-292 800.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,249Q3@186801|Clostridia,3XZEB@572511|Blautia 186801|Clostridia V Polysaccharide biosynthesis C-terminal domain - - - - - - - - - - - - MatE KKPNOBBG_03466 33035.JPJF01000001_gene2574 1.05e-279 763.0 COG0673@1|root,COG0673@2|Bacteria,1TSPV@1239|Firmicutes,24DUU@186801|Clostridia,3Y29S@572511|Blautia 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03467 33035.JPJF01000001_gene2573 6.73e-189 526.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia,3XZGR@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03468 33035.JPJF01000001_gene2572 5.68e-202 560.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03469 33035.JPJF01000001_gene2571 0.0 883.0 COG1653@1|root,COG1653@2|Bacteria,1UG52@1239|Firmicutes,24CJR@186801|Clostridia,3XZR7@572511|Blautia 186801|Clostridia G ABC transporter periplasmic binding protein YcjN precursor - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03470 33035.JPJF01000001_gene2570 7.5e-202 559.0 COG2207@1|root,COG2207@2|Bacteria,1U46S@1239|Firmicutes,24CVZ@186801|Clostridia,3XZY9@572511|Blautia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_03471 33035.JPJF01000001_gene2569 3.89e-101 293.0 COG2731@1|root,COG2731@2|Bacteria,1U3YR@1239|Firmicutes,24MGA@186801|Clostridia,3Y0TZ@572511|Blautia 186801|Clostridia G COG COG2731 Beta-galactosidase, beta subunit - - - - - - - - - - - - DUF386 KKPNOBBG_03472 33035.JPJF01000001_gene2568 1.1e-165 463.0 COG2755@1|root,COG2755@2|Bacteria,1VCTB@1239|Firmicutes,24GZV@186801|Clostridia,3Y1E4@572511|Blautia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_03473 33035.JPJF01000001_gene2567 1.54e-250 687.0 28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia,3XZQV@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_03474 33035.JPJF01000001_gene2566 1.17e-73 221.0 COG0375@1|root,COG0375@2|Bacteria,1V8EK@1239|Firmicutes,25CVT@186801|Clostridia 186801|Clostridia S Hydrogenase nickel insertion protein HypA - - - ko:K04651 - - - - ko00000,ko03110 - - - HypA KKPNOBBG_03475 33035.JPJF01000001_gene2565 0.0 1755.0 COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3XZ32@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2 KKPNOBBG_03476 33035.JPJF01000001_gene2564 5.8e-146 412.0 COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,3XZ4U@572511|Blautia 186801|Clostridia KO UreA amidohydrolase (urease) regulatory and maturation protein UreG hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW KKPNOBBG_03477 476272.RUMHYD_02275 3.1e-109 320.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2PT@1239|Firmicutes,24H78@186801|Clostridia,3Y1TI@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_03478 476272.RUMHYD_02274 2.01e-229 647.0 COG0662@1|root,COG2972@1|root,COG0662@2|Bacteria,COG2972@2|Bacteria,1V0JU@1239|Firmicutes,24DRA@186801|Clostridia,3Y16I@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_03479 476272.RUMHYD_02272 1.6e-260 719.0 COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,3XYZQ@572511|Blautia 186801|Clostridia E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT KKPNOBBG_03480 1202962.KB907151_gene935 8.76e-99 307.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF KKPNOBBG_03481 33035.JPJF01000001_gene2563 8.82e-241 669.0 COG0642@1|root,COG2205@2|Bacteria,1TRC1@1239|Firmicutes,249XJ@186801|Clostridia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_03482 33035.JPJF01000001_gene2562 2.94e-140 398.0 COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,24843@186801|Clostridia,3XYGU@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03483 33035.JPJF01000001_gene2561 3.97e-167 468.0 COG1136@1|root,COG1136@2|Bacteria,1TQU8@1239|Firmicutes,24AM8@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03484 33035.JPJF01000001_gene2560 0.0 1257.0 COG0577@1|root,COG0577@2|Bacteria,1TQ3S@1239|Firmicutes,248TI@186801|Clostridia 186801|Clostridia V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_03485 33035.JPJF01000001_gene2556 1.67e-51 163.0 COG5566@1|root,COG5566@2|Bacteria,1VEZS@1239|Firmicutes,24QVB@186801|Clostridia 186801|Clostridia S COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - Mor KKPNOBBG_03486 33035.JPJF01000001_gene2555 2.02e-104 305.0 COG4332@1|root,COG4332@2|Bacteria,1VBBZ@1239|Firmicutes,24H5E@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1062) - - - - - - - - - - - - DUF1062 KKPNOBBG_03487 1301100.HG529292_gene5164 3.28e-160 469.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae 186801|Clostridia C Na H antiporter - - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter KKPNOBBG_03488 457415.HMPREF1006_01927 9.65e-31 124.0 COG1319@1|root,COG1319@2|Bacteria,3TBFW@508458|Synergistetes 508458|Synergistetes C PFAM FAD binding domain in molybdopterin dehydrogenase - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 KKPNOBBG_03489 1378168.N510_01976 9.03e-69 212.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes 1239|Firmicutes C Aerobic-type carbon monoxide dehydrogenase small subunit CoxS cutS - 1.17.1.5,1.2.5.3 ko:K03518,ko:K20446 ko00760,ko01120,map00760,map01120 - R01720,R11168 RC00589,RC02800 ko00000,ko00001,ko01000 - - - Fer2,Fer2_2 KKPNOBBG_03490 1519439.JPJG01000091_gene628 2.01e-217 636.0 COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,2N87A@216572|Oscillospiraceae 186801|Clostridia C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 KKPNOBBG_03499 33035.JPJF01000037_gene2900 5.03e-111 321.0 COG1595@1|root,COG1595@2|Bacteria,1V55A@1239|Firmicutes,24GME@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_03500 33035.JPJF01000037_gene2901 5.6e-192 539.0 29WCT@1|root,30HYG@2|Bacteria,1TYPB@1239|Firmicutes,258RC@186801|Clostridia,3Y1W1@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4179) - - - - - - - - - - - - DUF4179 KKPNOBBG_03501 33035.JPJF01000037_gene2902 2.33e-191 530.0 28P0Q@1|root,2ZBX8@2|Bacteria,1V22P@1239|Firmicutes,248XV@186801|Clostridia,3XZCT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_03502 33035.JPJF01000037_gene2903 1.53e-304 833.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XZAY@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 mepA_10 - - - - - - - - - - - MatE KKPNOBBG_03503 33035.JPJF01000037_gene2904 4.26e-51 163.0 2BNPY@1|root,32HD2@2|Bacteria,1UFV1@1239|Firmicutes,25MSW@186801|Clostridia,3Y1Y7@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03504 33035.JPJF01000037_gene2905 2.91e-315 858.0 COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,3XZIV@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP KKPNOBBG_03505 33035.JPJF01000037_gene2906 2.52e-115 332.0 COG2519@1|root,COG2519@2|Bacteria,1V6VU@1239|Firmicutes,24JEE@186801|Clostridia,3XZYS@572511|Blautia 186801|Clostridia J Putative rRNA methylase - - - - - - - - - - - - rRNA_methylase KKPNOBBG_03506 33035.JPJF01000037_gene2907 5.77e-186 519.0 COG2385@1|root,COG2385@2|Bacteria,1TQSI@1239|Firmicutes,249H0@186801|Clostridia,3Y01U@572511|Blautia 186801|Clostridia D COG COG2385 Sporulation protein and related proteins spoIID - - ko:K06381 - - - - ko00000 - - - SpoIID KKPNOBBG_03508 33035.JPJF01000037_gene2908 6.92e-137 393.0 COG0739@1|root,COG0739@2|Bacteria,1VATR@1239|Firmicutes,24N76@186801|Clostridia,3Y09E@572511|Blautia 186801|Clostridia M COG COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 KKPNOBBG_03509 33035.JPJF01000037_gene2909 0.0 985.0 COG0791@1|root,COG3266@1|root,COG3584@1|root,COG0791@2|Bacteria,COG3266@2|Bacteria,COG3584@2|Bacteria,1TSZ0@1239|Firmicutes,25B1S@186801|Clostridia,3Y1DB@572511|Blautia 186801|Clostridia M 3D domain - - 3.4.14.13 ko:K20742 - - - - ko00000,ko01000,ko01002 - - - 3D,NLPC_P60,SH3_3 KKPNOBBG_03510 33035.JPJF01000037_gene2910 2.79e-49 156.0 COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,3Y0F0@572511|Blautia 186801|Clostridia L endonuclease containing a URI domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG KKPNOBBG_03511 33035.JPJF01000037_gene2911 4.11e-93 276.0 2DTES@1|root,33K1J@2|Bacteria,1UDZV@1239|Firmicutes,24VSS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03513 33035.JPJF01000037_gene2912 0.0 1066.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_03514 33035.JPJF01000037_gene2913 3.2e-295 815.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSBI@1239|Firmicutes,24E47@186801|Clostridia,3XZZ0@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_03515 33035.JPJF01000037_gene2914 2.21e-296 811.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03516 33035.JPJF01000037_gene2915 3.83e-200 555.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XYIT@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03517 33035.JPJF01000037_gene2916 8.85e-179 499.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3XZD4@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K10119,ko:K10202 ko02010,map02010 M00196,M00205 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.18,3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03518 33035.JPJF01000037_gene2917 0.0 1299.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XZXF@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_03519 33035.JPJF01000037_gene2918 2.51e-159 449.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,3XYM7@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short,adh_short_C2 KKPNOBBG_03520 33035.JPJF01000037_gene2919 2.09e-247 681.0 COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,3XYYH@572511|Blautia 186801|Clostridia G Belongs to the metallo-dependent hydrolases superfamily. NagA family nagA - 3.5.1.25 ko:K01443 ko00520,ko01130,map00520,map01130 - R02059 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Amidohydro_1 KKPNOBBG_03521 33035.JPJF01000037_gene2920 5.85e-159 446.0 COG3010@1|root,COG3010@2|Bacteria,1TSR7@1239|Firmicutes,24AVB@186801|Clostridia,3XZHW@572511|Blautia 186801|Clostridia G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) nanE - 5.1.3.9 ko:K01788 ko00520,map00520 - R02087 RC00290 ko00000,ko00001,ko01000 - - - NanE KKPNOBBG_03522 33035.JPJF01000037_gene2921 7.76e-213 589.0 COG0329@1|root,COG0329@2|Bacteria,1TQRK@1239|Firmicutes,247ZW@186801|Clostridia,3XZN3@572511|Blautia 186801|Clostridia EM Belongs to the DapA family - - 4.1.3.3 ko:K01639 ko00520,map00520 - R01811 RC00159,RC00600 ko00000,ko00001,ko01000 - - - DHDPS KKPNOBBG_03523 33035.JPJF01000037_gene2922 0.0 927.0 COG0591@1|root,COG0591@2|Bacteria,1TQCK@1239|Firmicutes,25E9U@186801|Clostridia,3Y134@572511|Blautia 186801|Clostridia E Sodium:solute symporter family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF KKPNOBBG_03524 33035.JPJF01000037_gene2923 1.71e-104 301.0 COG2731@1|root,COG2731@2|Bacteria,1V3S9@1239|Firmicutes,24HIS@186801|Clostridia,3Y1K1@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF386) - - - - - - - - - - - - DUF386 KKPNOBBG_03525 33035.JPJF01000037_gene2924 4.77e-180 503.0 COG1940@1|root,COG1940@2|Bacteria,1TP04@1239|Firmicutes,248SD@186801|Clostridia,3XZGU@572511|Blautia 186801|Clostridia GK Psort location Cytoplasmic, score - - - - - - - - - - - - ROK KKPNOBBG_03526 33035.JPJF01000037_gene2925 4.78e-182 508.0 COG1737@1|root,COG1737@2|Bacteria,1TR5E@1239|Firmicutes,247Z7@186801|Clostridia,3XZRH@572511|Blautia 186801|Clostridia K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS KKPNOBBG_03527 33035.JPJF01000037_gene2926 1.86e-94 275.0 COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24JS4@186801|Clostridia,3Y0CR@572511|Blautia 186801|Clostridia P Belongs to the Fur family perR - - ko:K09825 - - - - ko00000,ko03000 - - - FUR KKPNOBBG_03528 33035.JPJF01000037_gene2927 2.46e-126 359.0 COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,3XYT1@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 rbr3A - - - - - - - - - - - Rubrerythrin KKPNOBBG_03529 33035.JPJF01000037_gene2928 5.35e-125 356.0 COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3XZBD@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 rbr - - - - - - - - - - - Rubrerythrin KKPNOBBG_03530 33035.JPJF01000037_gene2929 0.0 1174.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ8B@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_03531 556261.HMPREF0240_04367 2.34e-232 649.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae 186801|Clostridia V Mate efflux family protein - - - - - - - - - - - - MatE KKPNOBBG_03532 476272.RUMHYD_03477 1.65e-240 662.0 COG0371@1|root,COG0371@2|Bacteria,1V994@1239|Firmicutes 1239|Firmicutes C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH_2 KKPNOBBG_03533 556261.HMPREF0240_01120 5.22e-283 782.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,36E3W@31979|Clostridiaceae 186801|Clostridia G transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_03534 33035.JPJF01000001_gene2528 4.02e-303 831.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3XZ7Z@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_03535 33035.JPJF01000001_gene2529 1.64e-253 695.0 COG0407@1|root,COG0407@2|Bacteria,1VRN3@1239|Firmicutes,24Z8U@186801|Clostridia 186801|Clostridia H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III - - - - - - - - - - - - - KKPNOBBG_03536 33035.JPJF01000001_gene2530 6.36e-292 801.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292,ko:K16248 - - - - ko00000,ko02000 2.A.2 - - MFS_2,MFS_3 KKPNOBBG_03537 33035.JPJF01000001_gene2531 4.46e-297 817.0 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia 186801|Clostridia L Belongs to the DEAD box helicase family dbpA - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C KKPNOBBG_03538 411902.CLOBOL_05137 0.0 1645.0 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,21Z6D@1506553|Lachnoclostridium 186801|Clostridia T SnoaL-like domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg,SnoaL_3 KKPNOBBG_03539 33035.JPJF01000001_gene2532 1.57e-194 542.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZED@1239|Firmicutes,2490G@186801|Clostridia,3Y1IP@572511|Blautia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 KKPNOBBG_03540 33035.JPJF01000001_gene2533 1.43e-135 385.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,3XZYR@572511|Blautia 186801|Clostridia S Maltose acetyltransferase - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_03541 33035.JPJF01000001_gene2534 9.38e-273 751.0 COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,3XZ7G@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_03542 33035.JPJF01000001_gene2541 2e-143 406.0 COG0745@1|root,COG0745@2|Bacteria,1TQRT@1239|Firmicutes,24FGF@186801|Clostridia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03543 33035.JPJF01000001_gene2542 3.09e-193 542.0 COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_03544 33035.JPJF01000001_gene2543 7.09e-150 422.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XYM9@572511|Blautia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03545 33035.JPJF01000001_gene2544 0.0 1146.0 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1TQ8P@1239|Firmicutes,25E38@186801|Clostridia,3XZ2P@572511|Blautia 186801|Clostridia MV COG COG0577 ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_03546 33035.JPJF01000001_gene2545 2.1e-284 780.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia,3Y14V@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03547 33035.JPJF01000001_gene2546 6.51e-176 491.0 COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,24F6M@186801|Clostridia,3Y103@572511|Blautia 186801|Clostridia S Putative esterase - - - - - - - - - - - - Esterase KKPNOBBG_03548 33035.JPJF01000001_gene2547 1.36e-198 552.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_03549 33035.JPJF01000001_gene2548 0.0 1483.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3Y12B@572511|Blautia 186801|Clostridia F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC KKPNOBBG_03550 33035.JPJF01000001_gene2549 3.55e-77 231.0 COG0640@1|root,COG0640@2|Bacteria,1V6Z2@1239|Firmicutes,24JUM@186801|Clostridia 186801|Clostridia K Transcriptional regulator, ArsR family - - - - - - - - - - - - HTH_5 KKPNOBBG_03551 33035.JPJF01000001_gene2550 9.37e-144 409.0 COG2768@1|root,COG2768@2|Bacteria,1V2K1@1239|Firmicutes,24FX2@186801|Clostridia,3Y284@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_4,Fer4_9 KKPNOBBG_03552 33035.JPJF01000001_gene2551 5.41e-140 398.0 COG1011@1|root,COG1011@2|Bacteria,1V7T4@1239|Firmicutes,25ISP@186801|Clostridia,3Y1UM@572511|Blautia 186801|Clostridia S HAD-hyrolase-like - - - - - - - - - - - - - KKPNOBBG_03553 33035.JPJF01000001_gene2552 5.2e-222 616.0 COG3835@1|root,COG3835@2|Bacteria,1TTCF@1239|Firmicutes,24CMJ@186801|Clostridia,3Y0S2@572511|Blautia 186801|Clostridia KT Putative sugar diacid recognition - - - ko:K02647 - - - - ko00000,ko03000 - - - Diacid_rec,HTH_30 KKPNOBBG_03554 33035.JPJF01000001_gene2553 2.91e-241 667.0 COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,3XZPW@572511|Blautia 186801|Clostridia G Belongs to the glycerate kinase type-1 family glxK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase KKPNOBBG_03555 865861.AZSU01000002_gene2717 2.6e-163 515.0 COG0457@1|root,COG1672@1|root,COG3629@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,COG3629@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,36DWM@31979|Clostridiaceae 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C KKPNOBBG_03556 1256908.HMPREF0373_02600 1.2e-53 175.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,25WKC@186806|Eubacteriaceae 186801|Clostridia S BioY family bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY KKPNOBBG_03557 478749.BRYFOR_09435 3.45e-71 228.0 COG0662@1|root,COG4977@1|root,COG0662@2|Bacteria,COG4977@2|Bacteria,1UKNY@1239|Firmicutes,25G0J@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_03558 1304866.K413DRAFT_1489 0.0 993.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_03559 1392493.JIAB01000001_gene899 3.09e-163 489.0 COG3250@1|root,COG3250@2|Bacteria,1TQYV@1239|Firmicutes,248PU@186801|Clostridia,27UJN@186928|unclassified Lachnospiraceae 186801|Clostridia G Carbohydrate esterase, sialic acid-specific acetylesterase - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - Glyco_hydro_2_N,SASA KKPNOBBG_03562 397291.C804_04823 1.63e-227 649.0 COG2972@1|root,COG2972@2|Bacteria,1TPUF@1239|Firmicutes,2491H@186801|Clostridia,27JGZ@186928|unclassified Lachnospiraceae 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase KKPNOBBG_03563 397291.C804_04824 1.45e-238 672.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYK2@1239|Firmicutes,247MJ@186801|Clostridia,27K3M@186928|unclassified Lachnospiraceae 186801|Clostridia T cheY-homologous receiver domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_03564 397291.C804_04825 0.0 950.0 COG1653@1|root,COG1653@2|Bacteria,1TQWF@1239|Firmicutes,24CWD@186801|Clostridia,27IIE@186928|unclassified Lachnospiraceae 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03565 397291.C804_04826 2.49e-187 525.0 COG4209@1|root,COG4209@2|Bacteria,1TQ64@1239|Firmicutes,24YP3@186801|Clostridia,27KGJ@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03566 397291.C804_04827 1.54e-160 456.0 COG0395@1|root,COG0395@2|Bacteria,1TP14@1239|Firmicutes,2481Z@186801|Clostridia,27KBY@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03567 1226325.HMPREF1548_05296 1.7e-201 567.0 COG3405@1|root,COG3405@2|Bacteria,1U1E1@1239|Firmicutes,24878@186801|Clostridia,36FZI@31979|Clostridiaceae 186801|Clostridia G family 8 - - 3.2.1.156 ko:K15531 - - - - ko00000,ko01000 - GH8 - Dockerin_1,Glyco_hydro_8,Polysacc_deac_1 KKPNOBBG_03568 931276.Cspa_c48540 1.22e-214 610.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,36ES1@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 KKPNOBBG_03569 397291.C804_04828 3.45e-239 675.0 COG1653@1|root,COG1653@2|Bacteria,1TQWF@1239|Firmicutes,24CWD@186801|Clostridia,27IIE@186928|unclassified Lachnospiraceae 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03570 1449050.JNLE01000003_gene1468 4.12e-217 617.0 COG3507@1|root,COG3507@2|Bacteria,1TSKZ@1239|Firmicutes,24BRZ@186801|Clostridia,36FDY@31979|Clostridiaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - CBM_4_9,CBM_6,Esterase,Glyco_hydro_43 KKPNOBBG_03571 478749.BRYFOR_09465 0.0 1065.0 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,2492T@186801|Clostridia 186801|Clostridia L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 KKPNOBBG_03572 411902.CLOBOL_05577 1.56e-221 617.0 COG5433@1|root,COG5433@2|Bacteria,1UZWV@1239|Firmicutes,24DPT@186801|Clostridia,222BK@1506553|Lachnoclostridium 186801|Clostridia L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc KKPNOBBG_03573 742735.HMPREF9467_04919 1.4e-110 320.0 2B876@1|root,321FR@2|Bacteria,1UEHH@1239|Firmicutes,25JEK@186801|Clostridia,222GW@1506553|Lachnoclostridium 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03574 1235792.C808_04634 8.13e-56 176.0 COG1708@1|root,COG1708@2|Bacteria,1VVQY@1239|Firmicutes,250CG@186801|Clostridia,27UJQ@186928|unclassified Lachnospiraceae 186801|Clostridia S Nucleotidyltransferase domain - - - - - - - - - - - - NTP_transf_2 KKPNOBBG_03575 1235798.C817_02988 3.06e-72 219.0 COG1895@1|root,COG1895@2|Bacteria,1V7JU@1239|Firmicutes,24KQE@186801|Clostridia 186801|Clostridia S HEPN domain - - - - - - - - - - - - HEPN KKPNOBBG_03576 1232447.BAHW02000027_gene2055 3.16e-63 199.0 2DBT4@1|root,2ZAVD@2|Bacteria,1V0AF@1239|Firmicutes,24DH6@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Sigma70_r4 KKPNOBBG_03577 33035.JPJF01000100_gene3589 6.62e-233 677.0 2BZEU@1|root,30VT8@2|Bacteria,1V54M@1239|Firmicutes,24SSI@186801|Clostridia,3XZVW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_03578 33035.JPJF01000100_gene3588 2.71e-168 469.0 COG1180@1|root,COG1180@2|Bacteria,1V1GP@1239|Firmicutes,24G76@186801|Clostridia,3XZK7@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM KKPNOBBG_03580 33035.JPJF01000100_gene3587 6.96e-114 327.0 COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3XZVE@572511|Blautia 186801|Clostridia FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam KKPNOBBG_03581 33035.JPJF01000100_gene3586 2.03e-190 530.0 COG0646@1|root,COG0646@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,3XZSY@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans KKPNOBBG_03582 33035.JPJF01000100_gene3585 3.05e-136 387.0 COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,24HX6@186801|Clostridia,3Y0W7@572511|Blautia 186801|Clostridia S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc KKPNOBBG_03584 33035.JPJF01000100_gene3583 1.62e-256 703.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,3XZ13@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK KKPNOBBG_03585 33035.JPJF01000100_gene3582 0.0 997.0 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,3XZM7@572511|Blautia 186801|Clostridia L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 KKPNOBBG_03586 33035.JPJF01000100_gene3581 8.04e-72 216.0 COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,3Y02F@572511|Blautia 186801|Clostridia L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd KKPNOBBG_03587 33035.JPJF01000100_gene3580 4.04e-136 385.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3XZEE@572511|Blautia 186801|Clostridia L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 KKPNOBBG_03588 33035.JPJF01000100_gene3579 6.61e-256 702.0 COG1609@1|root,COG1609@2|Bacteria,1UYY5@1239|Firmicutes,24C8C@186801|Clostridia,3XZ1C@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_03589 33035.JPJF01000100_gene3578 4.31e-149 420.0 COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,3XYWX@572511|Blautia 186801|Clostridia H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA KKPNOBBG_03590 33035.JPJF01000100_gene3577 1.58e-200 555.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3XZ3S@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N KKPNOBBG_03591 33035.JPJF01000100_gene3576 1.02e-208 578.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3XZRN@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C KKPNOBBG_03592 33035.JPJF01000100_gene3575 6.09e-171 477.0 COG1418@1|root,COG1418@2|Bacteria,1V4QX@1239|Firmicutes,24JBS@186801|Clostridia,3Y0A7@572511|Blautia 186801|Clostridia S HD superfamily hydrolase - - - ko:K06950 - - - - ko00000 - - - HD KKPNOBBG_03593 1123075.AUDP01000020_gene1539 3.21e-70 220.0 2ADZG@1|root,313RY@2|Bacteria,1V6JT@1239|Firmicutes,24JCA@186801|Clostridia,3WIIG@541000|Ruminococcaceae 186801|Clostridia S sporulation protein yyaC - - - - - - - - - - - DUF1256 KKPNOBBG_03594 33035.JPJF01000100_gene3573 1.52e-238 665.0 COG1388@1|root,COG1388@2|Bacteria,1V4FJ@1239|Firmicutes,24IPI@186801|Clostridia,3XZF7@572511|Blautia 186801|Clostridia M Lysin motif - - - - - - - - - - - - LysM KKPNOBBG_03595 33035.JPJF01000100_gene3572 2.38e-231 642.0 2C3W5@1|root,2ZBIU@2|Bacteria,1UZRE@1239|Firmicutes,24BHB@186801|Clostridia,3XYH0@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_03596 33035.JPJF01000100_gene3571 4.87e-134 382.0 2DMJ6@1|root,32RY3@2|Bacteria,1VBBI@1239|Firmicutes,24SVX@186801|Clostridia,3Y00H@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Colicin_V KKPNOBBG_03597 33035.JPJF01000100_gene3570 3.92e-225 622.0 COG1609@1|root,COG1609@2|Bacteria,1UM0E@1239|Firmicutes,25B2H@186801|Clostridia,3Y2DY@572511|Blautia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_03598 33035.JPJF01000100_gene3569 5.13e-286 782.0 COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,3XZ5U@572511|Blautia 186801|Clostridia G ABC transporter periplasmic binding protein YcjN precursor - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03599 33035.JPJF01000100_gene3568 1.52e-157 447.0 COG1175@1|root,COG1175@2|Bacteria,1TQB1@1239|Firmicutes,25C4P@186801|Clostridia,3XZG3@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03600 33035.JPJF01000100_gene3567 1.65e-180 504.0 COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A3D@186801|Clostridia,3XYY7@572511|Blautia 186801|Clostridia P glycine betaine L-proline ABC transporter, permease protein - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03601 33035.JPJF01000100_gene3566 0.0 1097.0 COG0366@1|root,COG0366@2|Bacteria,1TP53@1239|Firmicutes,247XR@186801|Clostridia,3XZ6T@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 malL - 3.2.1.1,3.2.1.10 ko:K01176,ko:K01182 ko00052,ko00500,ko01100,ko04973,map00052,map00500,map01100,map04973 - R00801,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C KKPNOBBG_03602 33035.JPJF01000031_gene2297 5.78e-213 587.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_03603 33035.JPJF01000031_gene2298 3.88e-310 846.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia 186801|Clostridia G solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_03604 33035.JPJF01000031_gene2299 5.26e-209 578.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03605 33035.JPJF01000031_gene2300 2.01e-184 514.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,3Y0FC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03607 33035.JPJF01000031_gene2309 0.0 971.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3XZ7T@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - Na_Ala_symp KKPNOBBG_03608 573413.Spirs_0709 1.63e-172 488.0 COG1082@1|root,COG1082@2|Bacteria,2J9B4@203691|Spirochaetes 203691|Spirochaetes G PFAM AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N KKPNOBBG_03609 742740.HMPREF9474_00636 1.11e-156 449.0 COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,21ZD2@1506553|Lachnoclostridium 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03610 658655.HMPREF0988_02779 3.97e-107 331.0 COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,249WU@186801|Clostridia,27P31@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03611 428125.CLOLEP_00643 5.14e-97 295.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03612 428125.CLOLEP_00641 2.63e-99 300.0 COG0395@1|root,COG0395@2|Bacteria,1V3Y9@1239|Firmicutes,25C5H@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03613 66692.ABC0796 1.92e-43 160.0 COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,4HCS4@91061|Bacilli,1ZCPA@1386|Bacillus 91061|Bacilli S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03614 553973.CLOHYLEM_07268 4.91e-78 247.0 COG1082@1|root,COG1082@2|Bacteria,1VRFT@1239|Firmicutes,24Z5T@186801|Clostridia,223EZ@1506553|Lachnoclostridium 186801|Clostridia L Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_03615 642492.Clole_0677 8.58e-37 140.0 COG2207@1|root,COG2207@2|Bacteria,1U0UH@1239|Firmicutes,249Y8@186801|Clostridia 186801|Clostridia K Cupin domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_03616 33035.JPJF01000031_gene2310 9.58e-219 605.0 COG1143@1|root,COG1143@2|Bacteria,1UI0U@1239|Firmicutes,25E9M@186801|Clostridia 186801|Clostridia C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - Fer4,Fer4_6 KKPNOBBG_03617 33035.JPJF01000031_gene2311 1.31e-316 884.0 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,TPR_12,Trans_reg_C KKPNOBBG_03618 1226325.HMPREF1548_06044 0.0 1108.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_03619 1226325.HMPREF1548_06045 2.62e-70 214.0 COG1961@1|root,COG1961@2|Bacteria,1VTW1@1239|Firmicutes,24Z4E@186801|Clostridia 186801|Clostridia L Resolvase, N terminal domain - - - - - - - - - - - - Resolvase KKPNOBBG_03620 1226325.HMPREF1548_06046 2.34e-25 94.7 2FFQM@1|root,347MX@2|Bacteria,1VZ7D@1239|Firmicutes,24WVT@186801|Clostridia 186801|Clostridia S Transposon-encoded protein TnpW - - - - - - - - - - - - TnpW KKPNOBBG_03621 1226325.HMPREF1548_06048 2.74e-50 159.0 2AJW5@1|root,31AIZ@2|Bacteria,1V7QN@1239|Firmicutes,24JQH@186801|Clostridia,36PDP@31979|Clostridiaceae 186801|Clostridia S Helix-turn-helix domain - - - - - - - - - - - - HTH_16 KKPNOBBG_03622 742741.HMPREF9475_01934 3.1e-91 268.0 COG1595@1|root,COG1595@2|Bacteria,1TSMC@1239|Firmicutes,25FBE@186801|Clostridia,2240K@1506553|Lachnoclostridium 186801|Clostridia K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r4_2 KKPNOBBG_03623 742738.HMPREF9460_03118 2.24e-236 650.0 COG0820@1|root,COG0820@2|Bacteria,1TQDD@1239|Firmicutes,24AXB@186801|Clostridia,26A0E@186813|unclassified Clostridiales 186801|Clostridia H Radical SAM superfamily - - - - - - - - - - - - Fer4_14,Radical_SAM KKPNOBBG_03624 1226322.HMPREF1545_02565 5.17e-73 219.0 COG1396@1|root,COG1396@2|Bacteria,1V50Y@1239|Firmicutes,25BHS@186801|Clostridia,2N8I8@216572|Oscillospiraceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_03625 1226322.HMPREF1545_02564 7.74e-68 206.0 296J0@1|root,2ZTUJ@2|Bacteria,1V3IP@1239|Firmicutes,24H9K@186801|Clostridia,2N8QM@216572|Oscillospiraceae 186801|Clostridia S Bacterial mobilisation protein (MobC) - - - - - - - - - - - - MobC KKPNOBBG_03626 552396.HMPREF0863_02717 3.37e-306 836.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,3VNWF@526524|Erysipelotrichia 526524|Erysipelotrichia U Relaxase mobilization nuclease domain protein - - - - - - - - - - - - Relaxase KKPNOBBG_03628 33035.JPJF01000101_gene3269 8.14e-214 592.0 COG0039@1|root,COG0039@2|Bacteria,1TPSY@1239|Firmicutes,248DH@186801|Clostridia,3XZ3D@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 ldh - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N KKPNOBBG_03629 33035.JPJF01000057_gene3105 1.47e-238 660.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3XYME@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic KKPNOBBG_03630 33035.JPJF01000101_gene3268 1.94e-66 202.0 COG0051@1|root,COG0051@2|Bacteria,1V6C9@1239|Firmicutes,24JDC@186801|Clostridia,3XZZ4@572511|Blautia 186801|Clostridia J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 KKPNOBBG_03631 33035.JPJF01000101_gene3267 5.9e-144 406.0 COG0087@1|root,COG0087@2|Bacteria,1TPFT@1239|Firmicutes,247NH@186801|Clostridia,3XZ95@572511|Blautia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 KKPNOBBG_03632 33035.JPJF01000101_gene3266 3.98e-135 384.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,3XZH3@572511|Blautia 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 KKPNOBBG_03633 33035.JPJF01000101_gene3265 4.72e-62 190.0 COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia,3Y06M@572511|Blautia 186801|Clostridia J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 KKPNOBBG_03634 33035.JPJF01000101_gene3264 1.17e-199 553.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,3XZ12@572511|Blautia 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C KKPNOBBG_03635 33035.JPJF01000101_gene3263 3.05e-62 190.0 COG0185@1|root,COG0185@2|Bacteria,1V6CX@1239|Firmicutes,24JN3@186801|Clostridia,3Y09D@572511|Blautia 186801|Clostridia J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 KKPNOBBG_03636 537007.BLAHAN_06376 5.24e-84 248.0 COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,3XZZ2@572511|Blautia 186801|Clostridia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 KKPNOBBG_03637 33035.JPJF01000101_gene3261 1.19e-151 426.0 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,24833@186801|Clostridia,3XZ7Y@572511|Blautia 186801|Clostridia J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C KKPNOBBG_03638 537007.BLAHAN_06374 5.38e-101 292.0 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3XYIJ@572511|Blautia 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 KKPNOBBG_03639 33035.JPJF01000101_gene3259 3.01e-36 123.0 COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,24QV1@186801|Clostridia,3Y0MW@572511|Blautia 186801|Clostridia J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 KKPNOBBG_03640 457412.RSAG_02853 3.52e-48 154.0 COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,3WJV0@541000|Ruminococcaceae 186801|Clostridia J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 KKPNOBBG_03641 1256908.HMPREF0373_01063 1.48e-78 234.0 COG0093@1|root,COG0093@2|Bacteria,1V3N0@1239|Firmicutes,24H98@186801|Clostridia,25WCX@186806|Eubacteriaceae 186801|Clostridia J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 KKPNOBBG_03642 33035.JPJF01000101_gene3256 1.67e-66 202.0 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,3Y0BX@572511|Blautia 186801|Clostridia J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 KKPNOBBG_03643 33035.JPJF01000101_gene3255 9.39e-123 350.0 COG0094@1|root,COG0094@2|Bacteria,1TPE0@1239|Firmicutes,247X0@186801|Clostridia,3XZR3@572511|Blautia 186801|Clostridia J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C KKPNOBBG_03644 411468.CLOSCI_02212 2.73e-26 97.4 COG0199@1|root,COG0199@2|Bacteria,1VEF6@1239|Firmicutes,24QR1@186801|Clostridia,220VY@1506553|Lachnoclostridium 186801|Clostridia J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 KKPNOBBG_03645 33035.JPJF01000101_gene3254 1.42e-88 260.0 COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,3Y02G@572511|Blautia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 KKPNOBBG_03646 33035.JPJF01000101_gene3253 6.34e-121 345.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,3XYVK@572511|Blautia 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 KKPNOBBG_03647 537007.BLAHAN_06364 1.12e-73 221.0 COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,3XZZX@572511|Blautia 186801|Clostridia J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p KKPNOBBG_03648 33035.JPJF01000101_gene3251 1.2e-111 321.0 COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3XZM0@572511|Blautia 186801|Clostridia J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C KKPNOBBG_03649 33035.JPJF01000101_gene3250 2e-32 112.0 COG1841@1|root,COG1841@2|Bacteria,1VEG4@1239|Firmicutes,24QKC@186801|Clostridia,3Y0NM@572511|Blautia 186801|Clostridia J Ribosomal protein L30p/L7e rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 KKPNOBBG_03650 33035.JPJF01000101_gene3249 1.21e-93 274.0 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,24HAJ@186801|Clostridia,3XZUB@572511|Blautia 186801|Clostridia J Binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A KKPNOBBG_03651 33035.JPJF01000101_gene3248 1.99e-273 752.0 COG0201@1|root,COG0201@2|Bacteria,1TPHB@1239|Firmicutes,248T9@186801|Clostridia,3XYT7@572511|Blautia 186801|Clostridia U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY KKPNOBBG_03652 33035.JPJF01000101_gene3247 2.15e-152 428.0 COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,3XZAB@572511|Blautia 186801|Clostridia F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS20110 ADK,ADK_lid KKPNOBBG_03653 33035.JPJF01000101_gene3246 8.55e-172 479.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3XZ5M@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 KKPNOBBG_03654 33035.JPJF01000101_gene3245 2.56e-51 162.0 COG2163@1|root,COG2163@2|Bacteria,1UG5G@1239|Firmicutes,25NCZ@186801|Clostridia,3Y0WA@572511|Blautia 186801|Clostridia J COG2163 Ribosomal protein L14E L6E L27E - - - - - - - - - - - - - KKPNOBBG_03655 33035.JPJF01000101_gene3244 4.86e-45 145.0 COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,3Y0HJ@572511|Blautia 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a KKPNOBBG_03656 1123311.KB904457_gene666 1.16e-76 229.0 2C5R4@1|root,31VPY@2|Bacteria,1V8EP@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TnpV KKPNOBBG_03657 1123311.KB904457_gene665 2.5e-31 120.0 COG0286@1|root,COG0286@2|Bacteria,1TPGZ@1239|Firmicutes,4HA1J@91061|Bacilli 91061|Bacilli V type I restriction-modification system - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,Methylase_S,N6_Mtase KKPNOBBG_03658 33035.JPJF01000134_gene4530 0.0 949.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UUVK@1239|Firmicutes,25KDA@186801|Clostridia,3Y1S9@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_03659 33035.JPJF01000134_gene4529 0.0 1026.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_03660 33035.JPJF01000152_gene1832 1.6e-246 676.0 COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia 186801|Clostridia S domain protein - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_03661 33035.JPJF01000152_gene1831 1.99e-138 392.0 COG1102@1|root,COG1102@2|Bacteria,1V286@1239|Firmicutes,24KX2@186801|Clostridia 186801|Clostridia F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_03662 33035.JPJF01000152_gene1830 0.0 892.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,3XZU5@572511|Blautia 186801|Clostridia G COG COG2211 Na melibiose symporter and related transporters gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_03663 33035.JPJF01000152_gene1829 2.19e-190 532.0 COG1879@1|root,COG1879@2|Bacteria,1UZ0C@1239|Firmicutes,249QH@186801|Clostridia 186801|Clostridia G Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 KKPNOBBG_03664 33035.JPJF01000064_gene3842 6.92e-261 716.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3Y04D@572511|Blautia 186801|Clostridia C Iron-containing alcohol dehydrogenase gbsB - - - - - - - - - - - Fe-ADH KKPNOBBG_03665 33035.JPJF01000064_gene3841 2.74e-201 555.0 COG3718@1|root,COG3718@2|Bacteria,1TR6M@1239|Firmicutes,2491W@186801|Clostridia 186801|Clostridia G Myo-inositol catabolism protein IolB iolB - 5.3.1.30 ko:K03337 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08503 RC00541 ko00000,ko00001,ko01000 - - - KduI KKPNOBBG_03666 33035.JPJF01000064_gene3840 0.0 1271.0 COG3962@1|root,COG3962@2|Bacteria,1UI18@1239|Firmicutes,25EA8@186801|Clostridia 186801|Clostridia E Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) iolD - 3.7.1.22 ko:K03336 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R08603 RC02331 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N KKPNOBBG_03667 33035.JPJF01000064_gene3839 1.27e-250 687.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia 186801|Clostridia G Kinase, PfkB family iolC - 2.7.1.4,2.7.1.92 ko:K00847,ko:K03338 ko00051,ko00500,ko00520,ko00562,ko01100,ko01120,map00051,map00500,map00520,map00562,map01100,map01120 - R00760,R00867,R03920,R05661 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_03668 33035.JPJF01000064_gene3838 5.42e-232 640.0 COG1879@1|root,COG1879@2|Bacteria,1TX1B@1239|Firmicutes,25EA7@186801|Clostridia 186801|Clostridia K Periplasmic binding protein domain - - - - - - - - - - - - LacI,Peripla_BP_4 KKPNOBBG_03669 33035.JPJF01000064_gene3837 2.61e-303 832.0 COG2508@1|root,COG2508@2|Bacteria 2|Bacteria QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_03670 33035.JPJF01000064_gene3836 5.79e-122 350.0 COG0523@1|root,COG0523@2|Bacteria,1V755@1239|Firmicutes,24JV0@186801|Clostridia 1239|Firmicutes S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - cobW KKPNOBBG_03672 33035.JPJF01000064_gene3834 3.96e-253 697.0 COG0477@1|root,COG2814@2|Bacteria,1V0CF@1239|Firmicutes,24BRB@186801|Clostridia 186801|Clostridia EGP Transporter, major facilitator family protein - - - - - - - - - - - - MFS_1 KKPNOBBG_03673 33035.JPJF01000064_gene3833 6.32e-255 697.0 COG0407@1|root,COG0407@2|Bacteria,1V9U0@1239|Firmicutes,24MDE@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_03674 33035.JPJF01000064_gene3831 8.69e-180 500.0 COG0726@1|root,COG0726@2|Bacteria,1UZGG@1239|Firmicutes,249C9@186801|Clostridia,3Y04M@572511|Blautia 186801|Clostridia G Polysaccharide deacetylase pdaB - - - - - - - - - - - Polysacc_deac_1 KKPNOBBG_03675 33035.JPJF01000064_gene3829 8.48e-123 365.0 2A88Y@1|root,30XA4@2|Bacteria,1V3M4@1239|Firmicutes 1239|Firmicutes S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - DUF2812 KKPNOBBG_03676 33035.JPJF01000064_gene3828 2.1e-76 229.0 COG1695@1|root,COG1695@2|Bacteria,1VESB@1239|Firmicutes,25CVC@186801|Clostridia,3Y1WQ@572511|Blautia 186801|Clostridia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR KKPNOBBG_03677 33035.JPJF01000064_gene3827 2.74e-284 777.0 COG1478@1|root,COG1478@2|Bacteria,1TSTY@1239|Firmicutes,249IH@186801|Clostridia,3Y1FJ@572511|Blautia 186801|Clostridia S F420-0:Gamma-glutamyl ligase - - - - - - - - - - - - F420_ligase KKPNOBBG_03678 33035.JPJF01000064_gene3826 6.9e-27 98.2 2EIM1@1|root,33CCB@2|Bacteria,1VM79@1239|Firmicutes,24UNI@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03679 1123075.AUDP01000004_gene787 1.44e-142 413.0 COG3344@1|root,COG3344@2|Bacteria,1UZGS@1239|Firmicutes,247Z6@186801|Clostridia,3WIXG@541000|Ruminococcaceae 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 KKPNOBBG_03687 33035.JPJF01000040_gene5172 2.58e-113 325.0 COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,3Y05G@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yfcE1 - - ko:K07095 - - - - ko00000 - - - Metallophos_2 KKPNOBBG_03688 33035.JPJF01000040_gene5173 6.98e-137 387.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3XZMM@572511|Blautia 186801|Clostridia F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like KKPNOBBG_03689 33035.JPJF01000040_gene5174 6.58e-275 752.0 COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,3XYQ3@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 ypsC - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 KKPNOBBG_03690 33035.JPJF01000040_gene5175 7.73e-127 360.0 COG0622@1|root,COG0622@2|Bacteria,1V1X1@1239|Firmicutes,24GA4@186801|Clostridia,3XZ4B@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yfcE - - ko:K07095 - - - - ko00000 - - - Metallophos_2 KKPNOBBG_03691 33035.JPJF01000040_gene5176 1.69e-62 192.0 COG0607@1|root,COG0607@2|Bacteria,1VGXK@1239|Firmicutes,24R46@186801|Clostridia,3Y0GN@572511|Blautia 186801|Clostridia P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese KKPNOBBG_03693 428126.CLOSPI_02372 1.11e-06 60.5 COG0791@1|root,COG1876@1|root,COG0791@2|Bacteria,COG1876@2|Bacteria,1V1BR@1239|Firmicutes 1239|Firmicutes M NlpC p60 family - - 3.5.2.6 ko:K17836 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000,ko01504 - - - ChW,NLPC_P60,SH3_3 KKPNOBBG_03694 33035.JPJF01000040_gene5177 2.48e-135 384.0 COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia,3Y1PC@572511|Blautia 186801|Clostridia G SIS domain gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3,SIS_2 KKPNOBBG_03695 33035.JPJF01000040_gene5178 7.51e-237 652.0 COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,3Y148@572511|Blautia 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK KKPNOBBG_03696 33035.JPJF01000040_gene5179 0.0 1563.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,24DH1@186801|Clostridia 186801|Clostridia G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_03697 33035.JPJF01000040_gene5180 1.54e-185 517.0 COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,24C7R@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03698 33035.JPJF01000040_gene5181 5.32e-175 491.0 COG1175@1|root,COG1175@2|Bacteria,1TSRA@1239|Firmicutes,24E4R@186801|Clostridia 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K17238 ko02010,map02010 M00599 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.38 - - BPD_transp_1 KKPNOBBG_03699 33035.JPJF01000040_gene5182 0.0 891.0 COG1653@1|root,COG1653@2|Bacteria,1U0GS@1239|Firmicutes,24DMA@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03700 33035.JPJF01000040_gene5183 1.94e-271 745.0 COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3Y1MA@572511|Blautia 186801|Clostridia GK ROK family - - - - - - - - - - - - ROK KKPNOBBG_03701 33035.JPJF01000040_gene5184 1.31e-63 199.0 2E4RH@1|root,32ZK1@2|Bacteria,1VEUS@1239|Firmicutes,24QIW@186801|Clostridia,3Y0M1@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - DUF1700 KKPNOBBG_03702 33035.JPJF01000040_gene5185 3.6e-107 310.0 COG2426@1|root,COG2426@2|Bacteria,1V3UW@1239|Firmicutes,24HSW@186801|Clostridia,3XZYM@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Sm_multidrug_ex KKPNOBBG_03703 33035.JPJF01000040_gene5186 2.81e-278 761.0 COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia,3XZCR@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 yhdR - 2.6.1.1 ko:K11358 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_03704 33035.JPJF01000040_gene5187 0.0 1082.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3XZJG@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_03705 33035.JPJF01000040_gene5188 0.0 1100.0 COG1404@1|root,COG1404@2|Bacteria,1TQK9@1239|Firmicutes,25B1U@186801|Clostridia,3XYR2@572511|Blautia 186801|Clostridia O COG COG1404 Subtilisin-like serine proteases cspBA - - - - - - - - - - - Peptidase_S8 KKPNOBBG_03706 33035.JPJF01000040_gene5189 1.18e-176 493.0 COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,3XZWD@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 fnt - - ko:K02598 - - - - ko00000,ko02000 1.A.16.3 - - Form_Nir_trans KKPNOBBG_03707 457412.RSAG_03390 0.0 1035.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WHBU@541000|Ruminococcaceae 186801|Clostridia H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS KKPNOBBG_03708 33035.JPJF01000157_gene3600 1.96e-227 627.0 COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,3XYNT@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_03709 33035.JPJF01000144_gene2339 0.0 906.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia 186801|Clostridia Q Belongs to the ATP-dependent AMP-binding enzyme family dltA - 6.1.1.13 ko:K03367 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 - - - AMP-binding,AMP-binding_C KKPNOBBG_03710 33035.JPJF01000144_gene2338 2.45e-269 738.0 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia 186801|Clostridia M Membrane protein involved in D-alanine export dltB - - ko:K03739,ko:K19294 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 - - ko00000,ko00001,ko00002,ko01504 - - - MBOAT KKPNOBBG_03711 33035.JPJF01000144_gene2337 8.51e-41 135.0 COG0236@1|root,COG0236@2|Bacteria 2|Bacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis dltC GO:0000270,GO:0003674,GO:0005215,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0022857,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0051179,GO:0051234,GO:0055085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.1.1.13 ko:K02078,ko:K14188 ko00473,ko01503,ko02020,ko05150,map00473,map01503,map02020,map05150 M00725 R02718 RC00037,RC00094 ko00000,ko00001,ko00002,ko01000,ko01504 - - - PP-binding KKPNOBBG_03712 33035.JPJF01000144_gene2336 1.61e-255 703.0 COG3966@1|root,COG3966@2|Bacteria,1TSZU@1239|Firmicutes,24GMC@186801|Clostridia 186801|Clostridia M D-alanyl-lipoteichoic acid biosynthesis protein DltD dltD - - ko:K03740 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00725 - - ko00000,ko00001,ko00002,ko01504 - - - DltD KKPNOBBG_03713 33035.JPJF01000144_gene2335 1.38e-162 455.0 COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,249RQ@186801|Clostridia,3XYRX@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 kdpE - - ko:K07667 ko02020,ko02024,map02020,map02024 M00454 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_03714 33035.JPJF01000061_gene3656 0.0 1004.0 COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,KdpD KKPNOBBG_03715 33035.JPJF01000061_gene3657 3.56e-152 427.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,3XZJS@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 ktrA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N KKPNOBBG_03716 33035.JPJF01000061_gene3658 7.97e-293 803.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,3XZ2Q@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH KKPNOBBG_03717 33035.JPJF01000061_gene3659 1.81e-241 667.0 COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia,3XZPC@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 ytvI - - - - - - - - - - - AI-2E_transport KKPNOBBG_03718 33035.JPJF01000061_gene3660 3.86e-136 386.0 COG0494@1|root,COG0494@2|Bacteria,1V27D@1239|Firmicutes,24GB6@186801|Clostridia,3XZU2@572511|Blautia 186801|Clostridia L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX KKPNOBBG_03719 33035.JPJF01000061_gene3661 7.34e-134 381.0 COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,3XZK2@572511|Blautia 186801|Clostridia S Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins ribU - - - - - - - - - - - ECF_trnsprt KKPNOBBG_03720 537007.BLAHAN_05013 1.92e-63 202.0 2DSAP@1|root,32USN@2|Bacteria,1VDID@1239|Firmicutes,24RPQ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03723 33035.JPJF01000034_gene2840 1.84e-34 120.0 COG2261@1|root,COG2261@2|Bacteria 2|Bacteria S Transglycosylase associated protein ydaS - - - - - - - - - - - Transgly_assoc KKPNOBBG_03724 33035.JPJF01000034_gene2841 0.0 1196.0 COG3661@1|root,COG3661@2|Bacteria,1UKA3@1239|Firmicutes,24AI6@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase 67 aguA - 3.2.1.139 ko:K01235 - - - - ko00000,ko01000 - - - Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N KKPNOBBG_03725 33035.JPJF01000034_gene2843 2.75e-209 578.0 COG0395@1|root,COG0395@2|Bacteria,1TSYB@1239|Firmicutes,24AKM@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03726 33035.JPJF01000034_gene2844 4.11e-180 504.0 COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,248DR@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_03727 33035.JPJF01000034_gene2845 7.22e-308 842.0 COG1653@1|root,COG1653@2|Bacteria,1TQJV@1239|Firmicutes,24BK1@186801|Clostridia 186801|Clostridia G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_03728 33035.JPJF01000034_gene2846 0.0 1025.0 COG2972@1|root,COG2972@2|Bacteria,1UCQF@1239|Firmicutes,24EY1@186801|Clostridia 186801|Clostridia T signal transduction protein with a C-terminal ATPase domain - - - - - - - - - - - - His_kinase KKPNOBBG_03729 33035.JPJF01000034_gene2847 0.0 947.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZKW@1239|Firmicutes,249VE@186801|Clostridia 186801|Clostridia T Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_03731 97139.C824_02421 4.41e-181 516.0 COG3964@1|root,COG3964@2|Bacteria,1TPXM@1239|Firmicutes,24EFP@186801|Clostridia,36EDQ@31979|Clostridiaceae 186801|Clostridia S Amidohydrolase family - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 KKPNOBBG_03732 658655.HMPREF0988_02289 1.25e-144 424.0 COG2942@1|root,COG2942@2|Bacteria,1TQMG@1239|Firmicutes,24C1F@186801|Clostridia 186801|Clostridia G Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) - - 5.1.3.8 ko:K01787 ko00520,map00520 - R01207 RC00290 ko00000,ko00001,ko01000 - - - GlcNAc_2-epim KKPNOBBG_03733 658655.HMPREF0988_02290 1.12e-141 413.0 COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia 186801|Clostridia J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis - - 2.9.1.1,4.3.1.29 ko:K01042,ko:K17468 ko00030,ko00450,ko00970,ko01120,map00030,map00450,map00970,map01120 - R08219,R10408 RC00544,RC01246 ko00000,ko00001,ko01000 - - - SelA KKPNOBBG_03734 658655.HMPREF0988_02291 3.04e-109 323.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,27IXU@186928|unclassified Lachnospiraceae 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.30 ko:K00019,ko:K00059 ko00061,ko00072,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00072,map00333,map00650,map00780,map01040,map01100,map01130,map01212 M00083,M00088,M00572 R01361,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 KKPNOBBG_03735 97139.C824_02414 4.28e-159 456.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_03736 33035.JPJF01000034_gene2848 2.3e-184 513.0 2DBRG@1|root,2ZAKM@2|Bacteria,1UQ8F@1239|Firmicutes,24CHJ@186801|Clostridia,3XZRT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_03737 33035.JPJF01000034_gene2849 2.13e-142 402.0 COG0698@1|root,COG0698@2|Bacteria,1TQQJ@1239|Firmicutes,249IB@186801|Clostridia,3Y1AG@572511|Blautia 186801|Clostridia G Ribose-5-phosphate isomerase - - - - - - - - - - - - DUF3666,LacAB_rpiB KKPNOBBG_03738 33035.JPJF01000034_gene2850 1.68e-184 513.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,3XZ8F@572511|Blautia 186801|Clostridia IQ Psort location Cytoplasmic, score - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 KKPNOBBG_03739 33035.JPJF01000034_gene2851 8.4e-200 554.0 COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,24A00@186801|Clostridia,3XZQS@572511|Blautia 186801|Clostridia G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI KKPNOBBG_03740 33035.JPJF01000034_gene2852 3.25e-201 558.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1UX6U@1239|Firmicutes,25B1Q@186801|Clostridia,3XZRR@572511|Blautia 186801|Clostridia K methylphosphotriester-DNA alkyltransferase (AraC XylS family) K00567 - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_03741 33035.JPJF01000034_gene2853 6.01e-45 145.0 COG1925@1|root,COG1925@2|Bacteria,1UHH0@1239|Firmicutes,25Q8A@186801|Clostridia,3Y0VD@572511|Blautia 186801|Clostridia G PTS HPr component phosphorylation site - - - - - - - - - - - - PTS-HPr KKPNOBBG_03742 33035.JPJF01000034_gene2854 0.0 1204.0 COG3533@1|root,COG3533@2|Bacteria,1TNYA@1239|Firmicutes,24841@186801|Clostridia 186801|Clostridia G protein conserved in bacteria - - - ko:K09955 - - - - ko00000 - - - Glyco_hydro_127 KKPNOBBG_03743 33035.JPJF01000034_gene2855 4.86e-174 489.0 COG2207@1|root,COG2207@2|Bacteria,1VRKI@1239|Firmicutes,24G8Q@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_03744 33035.JPJF01000034_gene2856 2.29e-149 429.0 COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,3XZ3C@572511|Blautia 186801|Clostridia M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 KKPNOBBG_03745 33035.JPJF01000034_gene2857 2.74e-173 487.0 COG2207@1|root,COG2207@2|Bacteria,1V8DG@1239|Firmicutes,24I38@186801|Clostridia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_03746 33035.JPJF01000034_gene2858 1.17e-299 818.0 COG3345@1|root,COG3345@2|Bacteria,1TQ3Q@1239|Firmicutes,25E9S@186801|Clostridia 186801|Clostridia G Alpha galactosidase A - - - - - - - - - - - - Melibiase_2 KKPNOBBG_03747 180332.JTGN01000005_gene2866 3.03e-09 54.7 COG4637@1|root,COG4637@2|Bacteria,1TQ9X@1239|Firmicutes,247NI@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_03748 33035.JPJF01000034_gene2859 0.0 1064.0 COG4289@1|root,COG4289@2|Bacteria,1TSHI@1239|Firmicutes,24C95@186801|Clostridia 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2264) - - - - - - - - - - - - DUF2264 KKPNOBBG_03749 33035.JPJF01000034_gene2860 9.84e-284 774.0 COG1331@1|root,COG1331@2|Bacteria,1TQ83@1239|Firmicutes,24ZNJ@186801|Clostridia 186801|Clostridia O Unsaturated glucuronyl hydrolase - - 3.2.1.180 ko:K18581 - - R10867 RC00049,RC02427 ko00000,ko01000 - GH88 - Glyco_hydro_88 KKPNOBBG_03750 33035.JPJF01000034_gene2861 0.0 2078.0 COG3507@1|root,COG3534@1|root,COG3507@2|Bacteria,COG3534@2|Bacteria,1TPG2@1239|Firmicutes,24AVP@186801|Clostridia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminus - - - - - - - - - - - - Alpha-L-AF_C,Cadherin-like KKPNOBBG_03751 33035.JPJF01000034_gene2862 5.49e-215 594.0 COG5492@1|root,COG5492@2|Bacteria,1TW7Y@1239|Firmicutes,24AP8@186801|Clostridia 186801|Clostridia N domain, Protein - - - - - - - - - - - - - KKPNOBBG_03752 33035.JPJF01000034_gene2863 0.0 1535.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,3XZFJ@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF4982) - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Big_4,DUF4982,F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_03753 33035.JPJF01000034_gene2865 1.9e-312 853.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,3XYQN@572511|Blautia 186801|Clostridia V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE KKPNOBBG_03754 33035.JPJF01000034_gene2866 4.13e-140 397.0 COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia,3XZV2@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03755 33035.JPJF01000034_gene2867 8.91e-128 368.0 28ZKB@1|root,2ZMBN@2|Bacteria,1V2FX@1239|Firmicutes,24DMT@186801|Clostridia,3Y0U1@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03756 33035.JPJF01000034_gene2868 1.23e-168 472.0 2BQS3@1|root,32JNS@2|Bacteria,1U2HH@1239|Firmicutes,25IPM@186801|Clostridia,3Y20X@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03757 33035.JPJF01000034_gene2869 5.07e-244 673.0 2E29B@1|root,32XF1@2|Bacteria,1VDSY@1239|Firmicutes,25IV0@186801|Clostridia,3Y24R@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03760 397291.C804_05739 1.09e-30 123.0 COG4219@1|root,COG4219@2|Bacteria,1V2TD@1239|Firmicutes,25BGN@186801|Clostridia,27PYU@186928|unclassified Lachnospiraceae 186801|Clostridia KT BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M56 KKPNOBBG_03763 33035.JPJF01000034_gene2871 1.09e-225 622.0 COG2207@1|root,COG2207@2|Bacteria,1V3FC@1239|Firmicutes,24C4C@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_03764 33035.JPJF01000034_gene2872 0.0 1159.0 COG1874@1|root,COG1874@2|Bacteria,1TSHK@1239|Firmicutes,249IJ@186801|Clostridia 186801|Clostridia G beta-galactosidase - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_35 KKPNOBBG_03765 33035.JPJF01000034_gene2873 0.0 1029.0 COG1653@1|root,COG1653@2|Bacteria,1TS6H@1239|Firmicutes,24BIJ@186801|Clostridia 186801|Clostridia G Domain of unknown function (DUF3502) - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - DUF3502,SBP_bac_1 KKPNOBBG_03766 33035.JPJF01000034_gene2874 4.63e-200 556.0 COG0395@1|root,COG0395@2|Bacteria,1TS9S@1239|Firmicutes,24BF3@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026,ko:K17320 ko02010,map02010 M00207,M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03767 33035.JPJF01000034_gene2875 1.01e-216 599.0 COG4209@1|root,COG4209@2|Bacteria,1TT63@1239|Firmicutes,25C4W@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_03768 33035.JPJF01000034_gene2876 1.17e-225 624.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,249FN@186801|Clostridia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_03769 33035.JPJF01000034_gene2877 1.64e-155 438.0 COG4753@1|root,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24KCB@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_03770 33035.JPJF01000034_gene2878 0.0 987.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3XZ6E@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_03771 33035.JPJF01000034_gene2879 0.0 964.0 COG1653@1|root,COG1653@2|Bacteria,1UYZC@1239|Firmicutes,24CMN@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_03772 33035.JPJF01000034_gene2882 0.0 1145.0 COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,3XYH3@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 pepQ - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C KKPNOBBG_03773 33035.JPJF01000034_gene2883 0.0 1333.0 COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,3XYW2@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF KKPNOBBG_03774 33035.JPJF01000034_gene2884 0.0 912.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XYSC@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_03775 1235800.C819_02823 5.89e-32 123.0 2FEI3@1|root,346HK@2|Bacteria,1W0JF@1239|Firmicutes,253M0@186801|Clostridia,27SKP@186928|unclassified Lachnospiraceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - - KKPNOBBG_03776 33035.JPJF01000034_gene2886 2.43e-109 318.0 29WCS@1|root,30HYF@2|Bacteria,1US0F@1239|Firmicutes,259YE@186801|Clostridia,3Y1XC@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03777 33035.JPJF01000034_gene2887 2.31e-80 240.0 2DNZJ@1|root,32ZX7@2|Bacteria,1VHMI@1239|Firmicutes,24SBG@186801|Clostridia,3Y0VH@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF2752) - - - - - - - - - - - - DUF2752 KKPNOBBG_03778 33035.JPJF01000034_gene2888 1.11e-164 462.0 COG5523@1|root,COG5523@2|Bacteria,1VB3B@1239|Firmicutes,24N6Q@186801|Clostridia,3Y0AG@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF975 KKPNOBBG_03780 33035.JPJF01000034_gene2890 5.99e-193 560.0 COG1361@1|root,COG1361@2|Bacteria,1TQHN@1239|Firmicutes,24BUH@186801|Clostridia,3Y0PV@572511|Blautia 186801|Clostridia M COG NOG29868 non supervised orthologous group - - - - - - - - - - - - CARDB KKPNOBBG_03781 33035.JPJF01000034_gene2891 1.05e-129 372.0 COG1131@1|root,COG1131@2|Bacteria,1V1P4@1239|Firmicutes,249VI@186801|Clostridia,3XZV2@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03782 33035.JPJF01000034_gene2892 5.88e-125 360.0 2C82F@1|root,32X5P@2|Bacteria,1VC9W@1239|Firmicutes,24PT0@186801|Clostridia,3Y1TW@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03783 33035.JPJF01000034_gene2893 1.76e-162 460.0 28ITJ@1|root,2Z8SG@2|Bacteria,1V0TD@1239|Firmicutes,24AI9@186801|Clostridia,3Y182@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03784 33035.JPJF01000034_gene2894 1.78e-183 529.0 2CGG8@1|root,33288@2|Bacteria,1VR70@1239|Firmicutes,25E2I@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03785 33035.JPJF01000006_gene2072 6.01e-189 541.0 COG0642@1|root,COG2205@2|Bacteria,1TRD2@1239|Firmicutes,247M3@186801|Clostridia,3Y0A6@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_03786 33035.JPJF01000006_gene2073 2.63e-114 332.0 COG0745@1|root,COG0745@2|Bacteria,1TQSA@1239|Firmicutes,24F54@186801|Clostridia,3Y2DR@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03788 1121115.AXVN01000038_gene3341 2.47e-153 453.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17,2.7.1.30 ko:K00854,ko:K00864 ko00040,ko00561,ko01100,ko03320,ko04626,map00040,map00561,map01100,map03320,map04626 M00014 R00847,R01639 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FGGY_C,FGGY_N KKPNOBBG_03789 1123075.AUDP01000029_gene2177 1.06e-47 181.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3WK3M@541000|Ruminococcaceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 KKPNOBBG_03790 1304284.L21TH_0952 9.94e-151 432.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY KKPNOBBG_03791 1123075.AUDP01000029_gene2179 9.27e-139 403.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3WGTC@541000|Ruminococcaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY KKPNOBBG_03792 1123075.AUDP01000029_gene2180 5.58e-100 300.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3WJDM@541000|Ruminococcaceae 186801|Clostridia EP ABC-type dipeptide oligopeptide nickel transport systems, permease components appC - - - - - - - - - - - BPD_transp_1,OppC_N KKPNOBBG_03793 1304875.JAFZ01000001_gene1618 3.99e-100 304.0 COG0601@1|root,COG0601@2|Bacteria,3TAGV@508458|Synergistetes 508458|Synergistetes P ABC transporter, permease protein - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_03795 1089545.KB913037_gene738 3.4e-103 304.0 2EXVQ@1|root,33R4U@2|Bacteria,2IDZ0@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 KKPNOBBG_03796 1452536.JARE01000031_gene965 1.8e-40 147.0 COG1028@1|root,COG1028@2|Bacteria,2INZY@201174|Actinobacteria 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 KKPNOBBG_03797 1121115.AXVN01000038_gene3345 2.24e-49 174.0 COG2390@1|root,COG2390@2|Bacteria,1TPUB@1239|Firmicutes,25D2S@186801|Clostridia,3Y1VG@572511|Blautia 186801|Clostridia K Putative sugar-binding domain sorC - - - - - - - - - - - HTH_24,Sugar-bind KKPNOBBG_03798 1232453.BAIF02000062_gene1909 7.7e-157 451.0 28IPH@1|root,2Z8PG@2|Bacteria,1TREB@1239|Firmicutes,248QM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03799 1163671.JAGI01000003_gene574 7.64e-142 407.0 COG3623@1|root,COG3623@2|Bacteria,1TSMS@1239|Firmicutes,247T6@186801|Clostridia,36FIC@31979|Clostridiaceae 186801|Clostridia G hexulose-6-phosphate isomerase ulaE - 5.1.3.22 ko:K03079 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R03244 RC00540 ko00000,ko00001,ko00002,ko01000 - - - AP_endonuc_2 KKPNOBBG_03800 1232447.BAHW02000009_gene311 2.97e-247 681.0 COG2220@1|root,COG2220@2|Bacteria,1TSFV@1239|Firmicutes,249MG@186801|Clostridia 186801|Clostridia S Beta-lactamase superfamily domain ulaG - - ko:K03476 ko00053,ko01100,ko01120,map00053,map01100,map01120 M00550 R07677 RC02793 ko00000,ko00001,ko00002,ko01000 - - - Lactamase_B_2,Lactamase_B_3 KKPNOBBG_03801 33035.JPJF01000006_gene2079 6.78e-265 728.0 COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia,3XZDS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase KKPNOBBG_03802 33035.JPJF01000006_gene2080 8.56e-289 789.0 COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,3XYWS@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 KKPNOBBG_03803 33035.JPJF01000006_gene2081 4.75e-96 280.0 COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia,3XZTJ@572511|Blautia 186801|Clostridia S Belongs to the UPF0735 family pheB - 5.4.99.5 ko:K06209 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R01715 RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4 KKPNOBBG_03804 33035.JPJF01000006_gene2082 1.4e-237 653.0 COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,3XZ5R@572511|Blautia 186801|Clostridia J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 KKPNOBBG_03805 537007.BLAHAN_04079 2.28e-40 134.0 2E7JQ@1|root,3321V@2|Bacteria,1VH9B@1239|Firmicutes,24S3M@186801|Clostridia,3Y0WH@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_03806 33035.JPJF01000006_gene2084 0.0 1622.0 COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3XYPH@572511|Blautia 186801|Clostridia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW KKPNOBBG_03807 33035.JPJF01000006_gene2085 2.25e-220 610.0 COG2188@1|root,COG2188@2|Bacteria,1TS1M@1239|Firmicutes,24CNY@186801|Clostridia 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_03808 33035.JPJF01000006_gene2086 0.0 1318.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3XYX5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_03809 33035.JPJF01000006_gene2087 8.8e-289 792.0 COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia,3XZJC@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein lacE - - ko:K10188 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03810 698758.AXY_05150 4.21e-131 379.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,4HCJ8@91061|Bacilli 91061|Bacilli K AraC family transcriptional regulator ydeE7 - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,GyrI-like,HTH_18 KKPNOBBG_03811 33035.JPJF01000006_gene2088 4.47e-121 346.0 COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,3XZRY@572511|Blautia 186801|Clostridia J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosom_S30AE_C,Ribosomal_S30AE KKPNOBBG_03812 33035.JPJF01000006_gene2089 3.01e-18 83.2 2C115@1|root,33J4D@2|Bacteria,1VQ7Z@1239|Firmicutes,24X7I@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03813 33035.JPJF01000003_gene1836 1.24e-171 479.0 COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,3XZD1@572511|Blautia 186801|Clostridia E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS17035 DapB_C,DapB_N KKPNOBBG_03814 33035.JPJF01000003_gene1837 1.06e-202 562.0 COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,3XZIM@572511|Blautia 186801|Clostridia H Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS KKPNOBBG_03815 33035.JPJF01000003_gene1838 1.8e-105 305.0 COG2109@1|root,COG2109@2|Bacteria,1V82Z@1239|Firmicutes,24J8J@186801|Clostridia,3Y0A2@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score btuR - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR KKPNOBBG_03816 33035.JPJF01000003_gene1839 1.85e-139 394.0 COG0629@1|root,COG0629@2|Bacteria,1TRWZ@1239|Firmicutes,248UD@186801|Clostridia,3XZI3@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 ssb1 - - - - - - - - - - - SSB KKPNOBBG_03817 33035.JPJF01000003_gene1840 0.0 1173.0 COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3XYY0@572511|Blautia 186801|Clostridia T GTP-binding protein TypA BipA homolog typA - - ko:K06207 - - - - ko00000 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2 KKPNOBBG_03818 33035.JPJF01000003_gene1841 0.0 1697.0 COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,3XYZE@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 9.98 adhE - 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - - Aldedh,Fe-ADH KKPNOBBG_03819 33035.JPJF01000003_gene1842 1.96e-110 320.0 COG0311@1|root,COG0311@2|Bacteria,1V3I6@1239|Firmicutes,24HRT@186801|Clostridia,3Y1IT@572511|Blautia 186801|Clostridia H SNO glutamine amidotransferase family pdxT - 4.3.3.6 ko:K08681 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS19495 SNO KKPNOBBG_03820 33035.JPJF01000003_gene1843 4.94e-189 527.0 COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,3Y0X6@572511|Blautia 186801|Clostridia H SOR/SNZ family pdxS - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ KKPNOBBG_03821 33035.JPJF01000003_gene1844 1.44e-228 634.0 COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,249SN@186801|Clostridia,3XYJW@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - CW_binding_1,ChW,Polysacc_deac_1 KKPNOBBG_03822 33035.JPJF01000003_gene1845 5.26e-314 860.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3XZM1@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 agcS - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp KKPNOBBG_03823 33035.JPJF01000003_gene1846 8.24e-255 702.0 COG1301@1|root,COG1301@2|Bacteria,1TP4N@1239|Firmicutes,2494N@186801|Clostridia,3XYHS@572511|Blautia 186801|Clostridia P Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF KKPNOBBG_03824 33035.JPJF01000003_gene1847 3.2e-118 339.0 COG1971@1|root,COG1971@2|Bacteria,1V4QK@1239|Firmicutes,24FY0@186801|Clostridia,3Y01B@572511|Blautia 186801|Clostridia P Probably functions as a manganese efflux pump mntP - - - - - - - - - - - Mntp KKPNOBBG_03825 33035.JPJF01000003_gene1848 0.0 1060.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,3Y197@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 43 - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 KKPNOBBG_03826 33035.JPJF01000003_gene1849 2.9e-143 405.0 COG4845@1|root,COG4845@2|Bacteria,1W19F@1239|Firmicutes,252N8@186801|Clostridia 186801|Clostridia V Chloramphenicol acetyltransferase - - - - - - - - - - - - CAT KKPNOBBG_03827 33035.JPJF01000003_gene1850 3.86e-140 397.0 COG4905@1|root,COG4905@2|Bacteria,1TQHG@1239|Firmicutes,2485W@186801|Clostridia,3Y1BV@572511|Blautia 186801|Clostridia S Putative ABC-transporter type IV - - - - - - - - - - - - ABC_trans_CmpB,DUF975 KKPNOBBG_03828 33035.JPJF01000003_gene1851 1.84e-83 246.0 COG0346@1|root,COG0346@2|Bacteria,1V6XU@1239|Firmicutes,24JFW@186801|Clostridia,3Y081@572511|Blautia 186801|Clostridia E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K08234 - - - - ko00000 - - - Glyoxalase KKPNOBBG_03829 33035.JPJF01000003_gene1852 6.96e-230 637.0 COG0642@1|root,COG2205@2|Bacteria,1VRNY@1239|Firmicutes,24EZG@186801|Clostridia,3Y1KA@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_03830 33035.JPJF01000003_gene1853 1.05e-139 396.0 COG0745@1|root,COG0745@2|Bacteria,1TT73@1239|Firmicutes,2487E@186801|Clostridia,3Y1GZ@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03831 33035.JPJF01000003_gene1854 1.75e-105 307.0 2F69Y@1|root,30GG7@2|Bacteria,1UFZ7@1239|Firmicutes,25N1D@186801|Clostridia,3Y20P@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03832 33035.JPJF01000003_gene1858 1.19e-184 520.0 2BP77@1|root,32HYI@2|Bacteria,1V84J@1239|Firmicutes,24JDS@186801|Clostridia,3Y1EA@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03833 33035.JPJF01000003_gene1859 0.0 1380.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XZXF@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_03834 33035.JPJF01000003_gene1860 0.0 962.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TRXY@1239|Firmicutes,24BYW@186801|Clostridia,3Y1D5@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_03835 33035.JPJF01000003_gene1861 0.0 1101.0 COG2972@1|root,COG2972@2|Bacteria,1UYIY@1239|Firmicutes,24ACA@186801|Clostridia,3Y1EM@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_03836 33035.JPJF01000003_gene1862 4.82e-192 534.0 COG0395@1|root,COG0395@2|Bacteria,1TRD1@1239|Firmicutes,24BQQ@186801|Clostridia,3Y16U@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03837 33035.JPJF01000003_gene1863 2e-209 579.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3Y0XA@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_03838 33035.JPJF01000003_gene1864 3.57e-312 852.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24C14@186801|Clostridia,3Y189@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03839 33035.JPJF01000003_gene1865 2.56e-305 835.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24C14@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_03840 33035.JPJF01000003_gene1866 7.02e-198 560.0 COG1277@1|root,COG1277@2|Bacteria,1TSXC@1239|Firmicutes,24CZ4@186801|Clostridia,3Y0PT@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC2_membrane_2,ABC2_membrane_3 KKPNOBBG_03841 33035.JPJF01000003_gene1867 2.84e-175 493.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3XZE4@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_03842 33035.JPJF01000003_gene1868 2.93e-86 264.0 2CJ98@1|root,326JR@2|Bacteria,1V6JM@1239|Firmicutes,24KX0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03843 33035.JPJF01000003_gene1869 2.34e-104 303.0 COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,25B0U@186801|Clostridia 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_03844 33035.JPJF01000061_gene3671 1.67e-31 124.0 2DWV7@1|root,3421J@2|Bacteria,1VX8N@1239|Firmicutes,251PW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03845 33035.JPJF01000003_gene1871 0.0 3612.0 COG1409@1|root,COG2366@1|root,COG5434@1|root,COG1409@2|Bacteria,COG2366@2|Bacteria,COG5434@2|Bacteria,1V0G8@1239|Firmicutes,25B0V@186801|Clostridia 186801|Clostridia M F5/8 type C domain - - - - - - - - - - - - F5_F8_type_C,FIVAR,Malectin KKPNOBBG_03846 33035.JPJF01000003_gene1872 1.46e-138 396.0 2DNA2@1|root,32WD5@2|Bacteria,1VDP6@1239|Firmicutes,24Q7U@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03847 33035.JPJF01000003_gene1873 9.5e-43 140.0 COG2732@1|root,COG2732@2|Bacteria,1VM0Z@1239|Firmicutes 1239|Firmicutes K Barnase inhibitor - - - ko:K03623 - - - - ko00000 - - - Barstar KKPNOBBG_03848 33035.JPJF01000003_gene1874 8.63e-104 302.0 COG4290@1|root,COG4290@2|Bacteria,1V7IV@1239|Firmicutes,24JGG@186801|Clostridia 186801|Clostridia F Ribonuclease - - - - - - - - - - - - Ribonuclease KKPNOBBG_03849 33035.JPJF01000003_gene1875 5.58e-167 470.0 COG0561@1|root,COG0561@2|Bacteria,1U3W2@1239|Firmicutes,2486H@186801|Clostridia,3Y0BQ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_3 KKPNOBBG_03850 33035.JPJF01000003_gene1876 6.09e-70 211.0 COG1694@1|root,COG1694@2|Bacteria,1VA3E@1239|Firmicutes,24NYY@186801|Clostridia 186801|Clostridia S MazG nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG-like KKPNOBBG_03851 33035.JPJF01000003_gene1877 0.0 1146.0 COG0840@1|root,COG2199@1|root,COG0840@2|Bacteria,COG2199@2|Bacteria,1TQG9@1239|Firmicutes,249KA@186801|Clostridia,3Y0T6@572511|Blautia 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF KKPNOBBG_03852 33035.JPJF01000003_gene1878 9.39e-191 530.0 COG1073@1|root,COG1073@2|Bacteria,1UHZK@1239|Firmicutes,25E87@186801|Clostridia 186801|Clostridia S Hydrolase, alpha beta domain protein - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 KKPNOBBG_03853 33035.JPJF01000003_gene1879 8.33e-266 733.0 COG2271@1|root,COG2271@2|Bacteria,1TQZE@1239|Firmicutes,25E40@186801|Clostridia,3Y11P@572511|Blautia 186801|Clostridia G Transmembrane secretion effector - - - - - - - - - - - - MFS_1 KKPNOBBG_03854 33035.JPJF01000003_gene1880 2.98e-139 397.0 29UNA@1|root,30FZX@2|Bacteria,1UEXX@1239|Firmicutes,25JXK@186801|Clostridia,3Y1Y6@572511|Blautia 186801|Clostridia S ABC-2 family transporter protein - - - - - - - - - - - - - KKPNOBBG_03855 33035.JPJF01000003_gene1881 3.18e-150 424.0 COG1131@1|root,COG1131@2|Bacteria,1VSFC@1239|Firmicutes,24ZTT@186801|Clostridia,3Y1JN@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_03856 33035.JPJF01000003_gene1882 4.76e-137 389.0 COG1309@1|root,COG1309@2|Bacteria,1TWE4@1239|Firmicutes,24C3H@186801|Clostridia,3Y1JV@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_03857 33035.JPJF01000003_gene1883 1.02e-294 808.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XYKT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_03858 33035.JPJF01000003_gene1884 3.34e-101 294.0 COG0454@1|root,COG0456@2|Bacteria,1V4FY@1239|Firmicutes,25E88@186801|Clostridia 186801|Clostridia K Acetyltransferase, gnat family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_9 KKPNOBBG_03859 33035.JPJF01000003_gene1885 0.0 945.0 COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,3Y0K5@572511|Blautia 186801|Clostridia F 5'-nucleotidase, C-terminal domain - - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 ko:K01119,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos KKPNOBBG_03860 33035.JPJF01000003_gene1886 0.0 1875.0 COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1TP9P@1239|Firmicutes,2485B@186801|Clostridia,3XZ3T@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PHP_C KKPNOBBG_03861 908340.HMPREF9406_2753 1.6e-164 470.0 COG2207@1|root,COG2207@2|Bacteria,1TRJ9@1239|Firmicutes,24BAP@186801|Clostridia,36FMR@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 KKPNOBBG_03862 1280689.AUJC01000015_gene5 0.0 1073.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae 186801|Clostridia C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_03863 1391647.AVSV01000002_gene1290 5.81e-16 80.9 COG2364@1|root,COG2364@2|Bacteria,1V47R@1239|Firmicutes,24AHJ@186801|Clostridia,36FXY@31979|Clostridiaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07149 - - - - ko00000 - - - YitT_membrane KKPNOBBG_03864 1105031.HMPREF1141_1166 3.65e-100 298.0 COG0813@1|root,COG0813@2|Bacteria,1TQPG@1239|Firmicutes,248G6@186801|Clostridia,36DR4@31979|Clostridiaceae 186801|Clostridia F Purine nucleoside phosphorylase deoD - 2.4.2.1 ko:K03784 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 KKPNOBBG_03865 246194.CHY_1963 3.3e-150 436.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,42F24@68295|Thermoanaerobacterales 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme KKPNOBBG_03866 457421.CBFG_03846 1.62e-131 385.0 COG1816@1|root,COG1816@2|Bacteria,1U44B@1239|Firmicutes,247KD@186801|Clostridia 186801|Clostridia F adenosine deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS13960 A_deaminase KKPNOBBG_03867 457421.CBFG_03845 4e-143 410.0 COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia 186801|Clostridia S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans KKPNOBBG_03868 457421.CBFG_03844 3.91e-160 453.0 COG1912@1|root,COG1912@2|Bacteria,1TSR3@1239|Firmicutes,24D3T@186801|Clostridia 186801|Clostridia S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans KKPNOBBG_03869 457421.CBFG_03843 1.86e-243 680.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MFS_2 KKPNOBBG_03870 457421.CBFG_03842 7.23e-84 259.0 COG3393@1|root,COG3393@2|Bacteria,1UFJG@1239|Firmicutes,24K1G@186801|Clostridia 186801|Clostridia K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - - KKPNOBBG_03872 457421.CBFG_03841 3.01e-103 306.0 COG2188@1|root,COG2188@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity ymfC - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA KKPNOBBG_03873 411470.RUMGNA_00405 9.37e-145 420.0 COG4607@1|root,COG4607@2|Bacteria,1UXCZ@1239|Firmicutes,2490M@186801|Clostridia 186801|Clostridia P periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 KKPNOBBG_03874 411467.BACCAP_04806 1.4e-143 409.0 COG4604@1|root,COG4604@2|Bacteria,1UHP5@1239|Firmicutes,25EJF@186801|Clostridia,268ER@186813|unclassified Clostridiales 186801|Clostridia P ATPases associated with a variety of cellular activities - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran KKPNOBBG_03875 1203606.HMPREF1526_01155 8.52e-166 471.0 COG4605@1|root,COG4605@2|Bacteria,1TP3V@1239|Firmicutes,24ATQ@186801|Clostridia,36FVU@31979|Clostridiaceae 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD KKPNOBBG_03876 478749.BRYFOR_08841 1.17e-184 521.0 COG4606@1|root,COG4606@2|Bacteria,1TSQX@1239|Firmicutes,249JQ@186801|Clostridia 186801|Clostridia P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD KKPNOBBG_03877 411470.RUMGNA_00409 1.01e-29 110.0 COG1733@1|root,COG1733@2|Bacteria 2|Bacteria K regulation of RNA biosynthetic process - - - - - - - - - - - - HxlR KKPNOBBG_03878 1226322.HMPREF1545_00820 1.69e-07 50.8 COG1245@1|root,COG1245@2|Bacteria,1VMA7@1239|Firmicutes,24UN4@186801|Clostridia,2N7V4@216572|Oscillospiraceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4 KKPNOBBG_03879 1226322.HMPREF1545_00821 5.88e-125 357.0 COG0348@1|root,COG0348@2|Bacteria,1UHUA@1239|Firmicutes,24BED@186801|Clostridia,2N68B@216572|Oscillospiraceae 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Fer4_5 KKPNOBBG_03880 411902.CLOBOL_01079 2.61e-09 52.8 2CEPR@1|root,2ZSJ9@2|Bacteria,1W4DB@1239|Firmicutes,24USC@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03881 33035.JPJF01000003_gene1910 0.0 1018.0 COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3XZG5@572511|Blautia 186801|Clostridia F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans KKPNOBBG_03882 33035.JPJF01000003_gene1911 2.92e-202 561.0 COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3XYZZ@572511|Blautia 186801|Clostridia P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer KKPNOBBG_03883 33035.JPJF01000003_gene1912 7.63e-100 296.0 COG1357@1|root,COG1357@2|Bacteria,1VAPB@1239|Firmicutes,24J9N@186801|Clostridia,3Y1PA@572511|Blautia 186801|Clostridia S Pentapeptide repeats (9 copies) - - - - - - - - - - - - Pentapeptide,Pentapeptide_4 KKPNOBBG_03884 33035.JPJF01000003_gene1913 9e-312 849.0 COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3XZMP@572511|Blautia 186801|Clostridia F GMP synthase C terminal domain - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase KKPNOBBG_03885 33035.JPJF01000003_gene1914 9.57e-299 817.0 COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,3XYQN@572511|Blautia 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_03886 33035.JPJF01000003_gene1915 2.76e-50 159.0 COG1609@1|root,COG1609@2|Bacteria,1VADF@1239|Firmicutes,24MXI@186801|Clostridia,3Y0IB@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 spoIIID - - ko:K06283 - - - - ko00000,ko03000 - - - SpoIIID KKPNOBBG_03887 33035.JPJF01000003_gene1916 7.93e-306 836.0 COG4905@1|root,COG4905@2|Bacteria,1TQUM@1239|Firmicutes,25CKD@186801|Clostridia,3XZ2R@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - ABC_trans_CmpB KKPNOBBG_03888 33035.JPJF01000003_gene1917 0.0 946.0 COG3012@1|root,COG4974@1|root,COG3012@2|Bacteria,COG4974@2|Bacteria,1UCSJ@1239|Firmicutes,24BGK@186801|Clostridia,3Y0NP@572511|Blautia 186801|Clostridia L Plasmid pRiA4b ORF-3-like protein - - - - - - - - - - - - PRiA4_ORF3,SEC-C KKPNOBBG_03889 33035.JPJF01000003_gene1918 3.44e-238 659.0 COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3XZI1@572511|Blautia 186801|Clostridia S Metallo-beta-lactamase superfamily - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Ada_Zn_binding,Lactamase_B KKPNOBBG_03890 33035.JPJF01000003_gene1919 4.66e-104 302.0 COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,3Y0H8@572511|Blautia 186801|Clostridia S Appr-1'-p processing enzyme ymdB - - - - - - - - - - - Macro KKPNOBBG_03891 33035.JPJF01000003_gene1920 5.61e-304 831.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3XZGF@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_03892 33035.JPJF01000003_gene1921 5.27e-216 602.0 COG2706@1|root,COG2706@2|Bacteria,1TQ3J@1239|Firmicutes,248JF@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.1.1.31 ko:K07404 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Lactonase KKPNOBBG_03893 33035.JPJF01000003_gene1922 2.48e-222 614.0 COG0673@1|root,COG0673@2|Bacteria,1VW9R@1239|Firmicutes,24A75@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_03894 33035.JPJF01000003_gene1925 1.38e-182 509.0 COG1600@1|root,COG1600@2|Bacteria,1V6AI@1239|Firmicutes,24HW4@186801|Clostridia 186801|Clostridia C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) - - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - - KKPNOBBG_03895 33035.JPJF01000003_gene1926 4.34e-283 776.0 COG2271@1|root,COG2271@2|Bacteria,1UZ2K@1239|Firmicutes,2493E@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - MFS_1 KKPNOBBG_03896 33035.JPJF01000003_gene1927 7.44e-186 518.0 COG0789@1|root,COG0789@2|Bacteria,1UZFF@1239|Firmicutes,24EUZ@186801|Clostridia 1239|Firmicutes K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 KKPNOBBG_03897 33035.JPJF01000003_gene1928 1.78e-149 422.0 COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,3XZN7@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D KKPNOBBG_03898 33035.JPJF01000003_gene1929 0.0 892.0 COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,3XZIG@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N KKPNOBBG_03899 33035.JPJF01000003_gene1930 0.0 1135.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3XZT0@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit ntpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn KKPNOBBG_03900 33035.JPJF01000003_gene1931 6.99e-65 198.0 COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,3Y0EG@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 atpF - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F KKPNOBBG_03901 33035.JPJF01000003_gene1932 3.23e-223 616.0 COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,3XYWC@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 ntpC - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 KKPNOBBG_03902 33035.JPJF01000003_gene1933 1.43e-76 234.0 COG1390@1|root,COG1390@2|Bacteria,1VDHZ@1239|Firmicutes,24H5N@186801|Clostridia,3Y03R@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpE - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E KKPNOBBG_03903 33035.JPJF01000003_gene1934 1.32e-96 282.0 COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,3XZV1@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 9.99 ntpK - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C KKPNOBBG_03904 33035.JPJF01000003_gene1935 0.0 1259.0 COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3XYZB@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 10.00 ntpI - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I KKPNOBBG_03906 33035.JPJF01000003_gene1937 3.47e-231 644.0 COG1879@1|root,COG1879@2|Bacteria,1TS2M@1239|Firmicutes,248GT@186801|Clostridia,3Y29T@572511|Blautia 186801|Clostridia G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 KKPNOBBG_03907 33035.JPJF01000003_gene1938 1.18e-213 594.0 COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,25CG4@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - AI-2E_transport KKPNOBBG_03908 33035.JPJF01000003_gene1939 6.64e-136 387.0 COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia,3XZWX@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 - - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 KKPNOBBG_03909 33035.JPJF01000003_gene1940 0.0 1470.0 COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,3XYPZ@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score ybhJ - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C KKPNOBBG_03910 33035.JPJF01000043_gene934 2.48e-252 693.0 COG3835@1|root,COG3835@2|Bacteria,1TQWD@1239|Firmicutes,24ZMW@186801|Clostridia,3Y17S@572511|Blautia 186801|Clostridia KT PucR C-terminal helix-turn-helix domain - - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 KKPNOBBG_03911 537007.BLAHAN_04566 1.07e-246 679.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,3XYK4@572511|Blautia 186801|Clostridia P Belongs to the ABC transporter superfamily ugpC_1 - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 KKPNOBBG_03912 33035.JPJF01000043_gene936 0.0 1225.0 COG5002@1|root,COG5002@2|Bacteria,1UM03@1239|Firmicutes,24F2S@186801|Clostridia,3XYZD@572511|Blautia 186801|Clostridia T COG COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_03913 33035.JPJF01000043_gene937 9.97e-161 451.0 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3XYV6@572511|Blautia 186801|Clostridia T COG COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP_1 - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_03914 33035.JPJF01000043_gene938 4.82e-56 174.0 2CGVU@1|root,32S4Q@2|Bacteria,1V9YX@1239|Firmicutes,24NX8@186801|Clostridia,3Y0DQ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_03915 33035.JPJF01000043_gene939 0.0 866.0 COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3XYYG@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI KKPNOBBG_03916 33035.JPJF01000043_gene940 2.91e-151 430.0 2BAZ7@1|root,324F4@2|Bacteria,1UQQQ@1239|Firmicutes,258H1@186801|Clostridia,3Y1M7@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03917 33035.JPJF01000043_gene941 3.95e-157 441.0 COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,247U5@186801|Clostridia,3XZ1X@572511|Blautia 186801|Clostridia F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively mtnN - 3.2.2.9 ko:K01243 ko00270,ko01100,ko01230,map00270,map01100,map01230 M00034,M00609 R00194,R01401 RC00063,RC00318 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 KKPNOBBG_03918 33035.JPJF01000043_gene942 6.65e-186 520.0 COG0329@1|root,COG0329@2|Bacteria,1V10S@1239|Firmicutes,2482C@186801|Clostridia,3Y1V0@572511|Blautia 186801|Clostridia EM Dihydrodipicolinate synthetase family - - 4.1.2.28 ko:K22397 ko00040,map00040 - R01782 RC00307,RC00572 ko00000,ko00001,ko01000 - - - DHDPS KKPNOBBG_03919 1123075.AUDP01000019_gene1608 4.82e-42 143.0 2E80U@1|root,332F1@2|Bacteria,1VGU4@1239|Firmicutes,25A2Q@186801|Clostridia,3WR2Z@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03920 1123075.AUDP01000019_gene1609 0.0 1679.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,3WHIV@541000|Ruminococcaceae 186801|Clostridia C Psort location CytoplasmicMembrane, score mop - 1.2.99.7 ko:K07469 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 KKPNOBBG_03921 1123075.AUDP01000019_gene1610 6.83e-281 797.0 COG0247@1|root,COG0493@1|root,COG0247@2|Bacteria,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,3WNTW@541000|Ruminococcaceae 186801|Clostridia CE Cysteine-rich domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_20,NAD_binding_8,Pyr_redox_2 KKPNOBBG_03922 1123075.AUDP01000019_gene1611 3.29e-39 130.0 2EGAW@1|root,33A2R@2|Bacteria,1VMAM@1239|Firmicutes,24WIE@186801|Clostridia,3WR2I@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03923 65093.PCC7418_1000 1.42e-06 56.2 COG0500@1|root,COG2226@2|Bacteria,1G2F7@1117|Cyanobacteria 1117|Cyanobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 KKPNOBBG_03924 1123075.AUDP01000019_gene1612 1.13e-56 180.0 2E4P6@1|root,32ZHX@2|Bacteria,1VCAE@1239|Firmicutes,24PE5@186801|Clostridia,3WQJP@541000|Ruminococcaceae 186801|Clostridia S Putative redox-active protein (C_GCAxxG_C_C) - - - - - - - - - - - - C_GCAxxG_C_C KKPNOBBG_03925 1123075.AUDP01000019_gene1613 2.04e-62 206.0 COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia 186801|Clostridia G HD domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 KKPNOBBG_03926 1123075.AUDP01000019_gene1614 2.61e-144 421.0 COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,3WH06@541000|Ruminococcaceae 186801|Clostridia E cysteine desulfurase family protein - - - - - - - - - - - - Aminotran_5 KKPNOBBG_03927 1123075.AUDP01000019_gene1616 8.1e-196 563.0 COG1964@1|root,COG1964@2|Bacteria,1TVES@1239|Firmicutes,248NC@186801|Clostridia,3WJ5T@541000|Ruminococcaceae 186801|Clostridia S Radical SAM superfamily - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Fer4_14,Radical_SAM KKPNOBBG_03928 1123075.AUDP01000019_gene1617 6.51e-111 345.0 COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WS0T@541000|Ruminococcaceae 186801|Clostridia H AMP-binding enzyme paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2,LuxC KKPNOBBG_03930 33035.JPJF01000043_gene943 0.0 1122.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia 186801|Clostridia EG Belongs to the IlvD Edd family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD KKPNOBBG_03932 622312.ROSEINA2194_00726 3.64e-11 59.3 2E82R@1|root,33CWV@2|Bacteria,1VME1@1239|Firmicutes,24UIA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03933 33035.JPJF01000043_gene946 2.73e-88 261.0 COG0681@1|root,COG0681@2|Bacteria,1V91S@1239|Firmicutes,25CNX@186801|Clostridia 186801|Clostridia U Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 KKPNOBBG_03934 33035.JPJF01000043_gene947 4.73e-177 501.0 29RI3@1|root,30CM2@2|Bacteria,1V5K6@1239|Firmicutes,24IPS@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03935 33035.JPJF01000043_gene948 9.11e-158 445.0 29M7E@1|root,3084V@2|Bacteria,1V5XP@1239|Firmicutes,24J0I@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03936 33035.JPJF01000043_gene949 7.75e-158 445.0 28NZ2@1|root,2ZBW1@2|Bacteria,1V2E1@1239|Firmicutes,24GPA@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03937 33035.JPJF01000043_gene950 9.48e-101 293.0 2E1E2@1|root,32WT6@2|Bacteria,1VE8G@1239|Firmicutes,24NJV@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03938 33035.JPJF01000043_gene951 1.57e-199 556.0 2BUGH@1|root,32PSI@2|Bacteria,1V6WG@1239|Firmicutes,24JP0@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03939 33035.JPJF01000043_gene952 4.31e-199 552.0 COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,3XZWU@572511|Blautia 186801|Clostridia M COG COG3764 Sortase (surface protein transpeptidase) - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase KKPNOBBG_03940 33035.JPJF01000043_gene953 1.37e-177 498.0 COG3764@1|root,COG3764@2|Bacteria,1UN9R@1239|Firmicutes,24CEQ@186801|Clostridia,3Y0YU@572511|Blautia 186801|Clostridia M Sortase family - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase KKPNOBBG_03941 411468.CLOSCI_01049 1.18e-33 140.0 COG4932@1|root,COG4932@2|Bacteria,1UVH8@1239|Firmicutes,24WIY@186801|Clostridia 186801|Clostridia M LPXTG cell wall anchor motif - - - - - - - - - - - - Gram_pos_anchor KKPNOBBG_03942 33035.JPJF01000043_gene955 8.7e-146 501.0 COG2304@1|root,COG4932@1|root,COG2304@2|Bacteria,COG4932@2|Bacteria,1UUVA@1239|Firmicutes,25KD1@186801|Clostridia,3Y1ZB@572511|Blautia 186801|Clostridia M COG COG4886 Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - KKPNOBBG_03943 33035.JPJF01000043_gene956 1.23e-39 131.0 2E82R@1|root,33CWV@2|Bacteria,1VME1@1239|Firmicutes,24UIA@186801|Clostridia,3Y234@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03944 33035.JPJF01000043_gene957 2.42e-90 266.0 2E82R@1|root,332GR@2|Bacteria,1VEUI@1239|Firmicutes,24QMN@186801|Clostridia,3Y1WP@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03945 33035.JPJF01000043_gene958 5.17e-292 798.0 COG3629@1|root,COG3629@2|Bacteria,1UWHI@1239|Firmicutes,24AC8@186801|Clostridia,3Y188@572511|Blautia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD,GGDEF,Trans_reg_C KKPNOBBG_03946 33035.JPJF01000043_gene959 1.68e-112 332.0 COG4968@1|root,COG4968@2|Bacteria,1VHI4@1239|Firmicutes,24R5K@186801|Clostridia 186801|Clostridia NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl KKPNOBBG_03947 397291.C804_01951 1.46e-75 238.0 COG0829@1|root,COG0829@2|Bacteria,1TVM2@1239|Firmicutes,24D1J@186801|Clostridia,27QK7@186928|unclassified Lachnospiraceae 186801|Clostridia O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureD - - ko:K03190 - - - - ko00000 - - - UreD KKPNOBBG_03948 1121115.AXVN01000010_gene2767 2.19e-123 353.0 COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,3XZ4U@572511|Blautia 186801|Clostridia KO UreA amidohydrolase (urease) regulatory and maturation protein UreG hypB - - ko:K04652 - - - - ko00000,ko03110 - - - cobW KKPNOBBG_03949 1292035.H476_2651 7.55e-80 246.0 COG0830@1|root,COG0830@2|Bacteria,1V2H0@1239|Firmicutes,24ETM@186801|Clostridia 186801|Clostridia O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF KKPNOBBG_03950 1121115.AXVN01000010_gene2765 6.86e-58 184.0 COG2371@1|root,COG2371@2|Bacteria,1V7SB@1239|Firmicutes,25DT7@186801|Clostridia 186801|Clostridia O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N KKPNOBBG_03951 457412.RSAG_01445 0.0 1012.0 COG0804@1|root,COG0804@2|Bacteria,1TPQP@1239|Firmicutes,24D62@186801|Clostridia,3WGSE@541000|Ruminococcaceae 186801|Clostridia E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha KKPNOBBG_03952 1235802.C823_05376 6.93e-52 166.0 COG0832@1|root,COG0832@2|Bacteria,1VAIA@1239|Firmicutes,24N65@186801|Clostridia 186801|Clostridia E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta,Urease_gamma KKPNOBBG_03953 1042156.CXIVA_25630 4.88e-51 162.0 COG0831@1|root,COG0831@2|Bacteria,1V7GU@1239|Firmicutes,24MN2@186801|Clostridia,36M20@31979|Clostridiaceae 186801|Clostridia E Belongs to the urease gamma subunit family ureA - 3.5.1.5 ko:K01430 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_gamma KKPNOBBG_03954 33035.JPJF01000043_gene961 1.87e-140 406.0 COG5464@1|root,COG5464@2|Bacteria,1U0NT@1239|Firmicutes,258VQ@186801|Clostridia,3Y22T@572511|Blautia 186801|Clostridia S transposase or invertase - - - - - - - - - - - - - KKPNOBBG_03955 1042156.CXIVA_01340 5.48e-242 666.0 COG0388@1|root,COG0388@2|Bacteria,1UYBG@1239|Firmicutes 1239|Firmicutes S Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide amiF - 3.5.1.49 ko:K01455 ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200 - R00524 RC02432,RC02810 ko00000,ko00001,ko01000 - - - CN_hydrolase KKPNOBBG_03956 931276.Cspa_c30930 1.07e-24 97.4 COG0347@1|root,COG0347@2|Bacteria,1VB4G@1239|Firmicutes,24MQ1@186801|Clostridia,36JU9@31979|Clostridiaceae 186801|Clostridia K PFAM Nitrogen regulatory protein P-II - - - ko:K02590 - - - - ko00000 - - - P-II KKPNOBBG_03957 632245.CLP_1058 1.82e-38 131.0 COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia,36JNI@31979|Clostridiaceae 186801|Clostridia K Belongs to the P(II) protein family - - - ko:K02589 - - - - ko00000 - - - P-II KKPNOBBG_03958 658086.HMPREF0994_04607 5.08e-103 305.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,27IPQ@186928|unclassified Lachnospiraceae 186801|Clostridia E ABC transporter - - - ko:K01996,ko:K11963 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - ABC_tran KKPNOBBG_03959 1196322.A370_03004 4.4e-107 317.0 COG4674@1|root,COG4674@2|Bacteria,1UIU8@1239|Firmicutes,25ES1@186801|Clostridia 186801|Clostridia S TIGRFAM urea ABC transporter, ATP-binding protein UrtD - - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C KKPNOBBG_03960 658086.HMPREF0994_04609 6.54e-158 455.0 COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia 186801|Clostridia E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998,ko:K11961 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 KKPNOBBG_03961 658086.HMPREF0994_04610 4.74e-135 391.0 COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,27K8D@186928|unclassified Lachnospiraceae 186801|Clostridia E Branched-chain amino acid transport system / permease component - - - ko:K01997,ko:K11960 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 KKPNOBBG_03962 1196322.A370_03001 4.2e-162 470.0 COG0683@1|root,COG0683@2|Bacteria,1V3KZ@1239|Firmicutes 1239|Firmicutes E Urea ABC transporter, urea binding protein - - - ko:K01999,ko:K11959 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5,Peripla_BP_6 KKPNOBBG_03963 1196322.A370_03000 6.85e-76 244.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT49@1239|Firmicutes,24DUZ@186801|Clostridia,36FC2@31979|Clostridiaceae 186801|Clostridia T response regulator - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_03964 203119.Cthe_1825 1.19e-128 417.0 COG0642@1|root,COG2972@1|root,COG0642@2|Bacteria,COG2972@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,3WSIY@541000|Ruminococcaceae 186801|Clostridia T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg,dCache_1 KKPNOBBG_03965 1196322.A370_02998 9.29e-105 319.0 COG2199@1|root,COG4251@1|root,COG3706@2|Bacteria,COG4251@2|Bacteria,1V3JC@1239|Firmicutes,25FH3@186801|Clostridia 186801|Clostridia T serine threonine protein kinase - - - - - - - - - - - - GGDEF,HATPase_c,Response_reg KKPNOBBG_03966 33035.JPJF01000043_gene962 1.74e-53 167.0 2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia,3Y0NQ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TSCPD KKPNOBBG_03967 33035.JPJF01000043_gene963 6.11e-212 590.0 COG1055@1|root,COG1055@2|Bacteria,1TQCH@1239|Firmicutes,25CD7@186801|Clostridia,3XZ25@572511|Blautia 186801|Clostridia P Citrate transporter ybiR - - - - - - - - - - - CitMHS KKPNOBBG_03968 33035.JPJF01000043_gene964 1.35e-252 697.0 COG0842@1|root,COG0842@2|Bacteria,1UYEY@1239|Firmicutes,24BCP@186801|Clostridia,3Y0H1@572511|Blautia 186801|Clostridia V COG COG0842 ABC-type multidrug transport system, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 KKPNOBBG_03969 33035.JPJF01000043_gene965 5.13e-215 600.0 COG0842@1|root,COG0842@2|Bacteria,1TR76@1239|Firmicutes,24A0F@186801|Clostridia,3Y0BD@572511|Blautia 186801|Clostridia V COG COG0842 ABC-type multidrug transport system, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 KKPNOBBG_03970 33035.JPJF01000043_gene966 2.92e-207 575.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,3XYW7@572511|Blautia 186801|Clostridia V COG COG1131 ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 KKPNOBBG_03971 33035.JPJF01000043_gene967 7.26e-199 557.0 COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,3Y033@572511|Blautia 186801|Clostridia T COG COG4585 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 KKPNOBBG_03972 33035.JPJF01000043_gene968 3e-131 374.0 COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia,3XZYD@572511|Blautia 186801|Clostridia T COG COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg KKPNOBBG_03974 33035.JPJF01000043_gene970 1.57e-103 303.0 COG4709@1|root,COG4709@2|Bacteria,1V5ZC@1239|Firmicutes,25CU8@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1700) - - - - - - - - - - - - DUF1700 KKPNOBBG_03975 33035.JPJF01000043_gene971 9.5e-68 205.0 COG1695@1|root,COG1695@2|Bacteria,1VA8U@1239|Firmicutes,25N2M@186801|Clostridia,3Y1W0@572511|Blautia 186801|Clostridia K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR KKPNOBBG_03976 33035.JPJF01000043_gene972 1.69e-75 226.0 2DRY9@1|root,33DNC@2|Bacteria,1V1G6@1239|Firmicutes,24GGT@186801|Clostridia,3Y05P@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_03977 33035.JPJF01000043_gene973 3.93e-59 182.0 2DPI5@1|root,3326E@2|Bacteria,1VIQZ@1239|Firmicutes,24QSZ@186801|Clostridia,3Y27B@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03978 33035.JPJF01000043_gene974 0.0 952.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,3XYYT@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N KKPNOBBG_03979 33035.JPJF01000043_gene975 0.0 1069.0 COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3XZEM@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL KKPNOBBG_03980 537007.BLAHAN_04105 9.48e-53 172.0 2DSCU@1|root,33FK5@2|Bacteria,1VKPN@1239|Firmicutes,24K3M@186801|Clostridia,3Y0VV@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_03981 33035.JPJF01000043_gene976 2.03e-120 355.0 2D2TB@1|root,32TDJ@2|Bacteria,1VB0C@1239|Firmicutes,24RN7@186801|Clostridia,3Y0P2@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4367 KKPNOBBG_03982 33035.JPJF01000043_gene977 2.7e-241 665.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,3XYKG@572511|Blautia 186801|Clostridia M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 KKPNOBBG_03983 33035.JPJF01000043_gene978 1.26e-101 296.0 COG1595@1|root,COG1595@2|Bacteria,1VGSN@1239|Firmicutes,251Y8@186801|Clostridia,3Y0JK@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K03088 - - - - ko00000,ko03021 - - - DUF134,Sigma70_r2 KKPNOBBG_03984 33035.JPJF01000043_gene979 2.49e-94 275.0 COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,3Y034@572511|Blautia 186801|Clostridia FG Psort location Cytoplasmic, score 8.87 hit - - ko:K02503 - - - - ko00000,ko04147 - - - HIT KKPNOBBG_03985 33035.JPJF01000043_gene980 4.44e-126 362.0 COG5000@1|root,COG5000@2|Bacteria,1VANU@1239|Firmicutes,24ETV@186801|Clostridia 186801|Clostridia T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c KKPNOBBG_03986 33035.JPJF01000043_gene981 9.39e-146 411.0 COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia,3XZZ9@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score gluP - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid KKPNOBBG_03987 33035.JPJF01000043_gene982 1.09e-208 590.0 COG1716@1|root,COG1716@2|Bacteria,1V550@1239|Firmicutes,24BVK@186801|Clostridia,3Y02T@572511|Blautia 186801|Clostridia T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA KKPNOBBG_03988 33035.JPJF01000043_gene983 2.04e-74 226.0 2EQ3G@1|root,33HPU@2|Bacteria,1VKDW@1239|Firmicutes,24V35@186801|Clostridia,3Y0MK@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - TadE KKPNOBBG_03990 556261.HMPREF0240_03284 9.21e-11 63.5 COG1989@1|root,COG1989@2|Bacteria,1VMFT@1239|Firmicutes,24T4E@186801|Clostridia,36T28@31979|Clostridiaceae 186801|Clostridia NOU Type IV leader peptidase family - - - - - - - - - - - - Peptidase_A24 KKPNOBBG_03991 33035.JPJF01000043_gene985 1.43e-172 484.0 COG4961@1|root,COG4961@2|Bacteria,1V9E1@1239|Firmicutes,24ET0@186801|Clostridia,3Y0C5@572511|Blautia 186801|Clostridia U Psort location Cytoplasmic, score - - - - - - - - - - - - TadE KKPNOBBG_03992 33035.JPJF01000043_gene986 3.07e-279 769.0 2BXNJ@1|root,2ZC8M@2|Bacteria,1UYM5@1239|Firmicutes,24B1U@186801|Clostridia,3Y2CX@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - - KKPNOBBG_03993 33035.JPJF01000043_gene987 1.51e-24 92.8 2EHSI@1|root,33BI9@2|Bacteria,1VK7K@1239|Firmicutes,24UF9@186801|Clostridia,3Y0UH@572511|Blautia 186801|Clostridia S Putative Flagellin, Flp1-like, domain - - - - - - - - - - - - Flp1_like KKPNOBBG_03994 33035.JPJF01000043_gene988 2.59e-210 591.0 COG2064@1|root,COG2064@2|Bacteria,1V2C3@1239|Firmicutes,24AN4@186801|Clostridia,3Y01Z@572511|Blautia 186801|Clostridia NU Psort location CytoplasmicMembrane, score - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF KKPNOBBG_03995 33035.JPJF01000043_gene989 4.94e-162 455.0 COG4965@1|root,COG4965@2|Bacteria,1V6PB@1239|Firmicutes,24JBR@186801|Clostridia,3XZRG@572511|Blautia 186801|Clostridia U Psort location CytoplasmicMembrane, score tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF KKPNOBBG_03996 537007.BLAHAN_04120 2.24e-173 496.0 COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3XZAC@572511|Blautia 186801|Clostridia U flp pilus assembly ATPase CpaF ptlH - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE KKPNOBBG_03997 33035.JPJF01000057_gene3114 7.2e-193 540.0 COG1192@1|root,COG1192@2|Bacteria,1V11K@1239|Firmicutes,24FDX@186801|Clostridia,3XZ68@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA_31 KKPNOBBG_03998 33035.JPJF01000057_gene3113 1.02e-103 301.0 COG4960@1|root,COG4960@2|Bacteria,1UPND@1239|Firmicutes,25HJR@186801|Clostridia,3Y0GG@572511|Blautia 186801|Clostridia OU Type IV leader peptidase family - - 3.4.23.43 ko:K02278 - - - - ko00000,ko01000,ko02035,ko02044 - - - Peptidase_A24 KKPNOBBG_03999 33035.JPJF01000057_gene3112 2.24e-140 397.0 COG2755@1|root,COG2755@2|Bacteria,1V2BU@1239|Firmicutes,24BSW@186801|Clostridia,3Y0F9@572511|Blautia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_04000 33035.JPJF01000057_gene3111 5.75e-103 299.0 COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,24I4E@186801|Clostridia,3XZYY@572511|Blautia 186801|Clostridia S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit KKPNOBBG_04001 33035.JPJF01000057_gene3110 4.21e-276 760.0 COG0534@1|root,COG0534@2|Bacteria,1TP5P@1239|Firmicutes,247PQ@186801|Clostridia,3XYK2@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - MatE KKPNOBBG_04002 33035.JPJF01000057_gene3109 3.42e-206 572.0 COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3XZJH@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP KKPNOBBG_04004 33035.JPJF01000057_gene3107 1.63e-246 688.0 COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,3Y12V@572511|Blautia 186801|Clostridia M Bacterial capsule synthesis protein PGA_cap capA - - ko:K07282 - - - - ko00000 - - - PGA_cap KKPNOBBG_04005 33035.JPJF01000057_gene3106 1.78e-224 622.0 COG3594@1|root,COG3594@2|Bacteria,1TPGY@1239|Firmicutes,24IKC@186801|Clostridia,3Y0PP@572511|Blautia 186801|Clostridia G Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 KKPNOBBG_04006 33035.JPJF01000057_gene3105 2.2e-272 746.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3XYME@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic KKPNOBBG_04007 33035.JPJF01000057_gene3104 7.89e-244 675.0 COG1653@1|root,COG1653@2|Bacteria,1TQJU@1239|Firmicutes,24AHT@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04008 33035.JPJF01000057_gene3103 3.12e-275 751.0 COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia,3XYWH@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 KKPNOBBG_04009 33035.JPJF01000057_gene3102 7.06e-191 531.0 COG0395@1|root,COG0395@2|Bacteria,1TSJ9@1239|Firmicutes,24ERB@186801|Clostridia,3Y1FC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04010 33035.JPJF01000057_gene3101 9e-189 526.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,3Y15X@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04011 33035.JPJF01000057_gene3100 1.08e-297 813.0 COG2182@1|root,COG2182@2|Bacteria,1UI14@1239|Firmicutes,25EA2@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_04012 33035.JPJF01000057_gene3099 0.0 1068.0 COG2972@1|root,COG2972@2|Bacteria,1TSE1@1239|Firmicutes,24B0H@186801|Clostridia,3Y124@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04013 33035.JPJF01000057_gene3098 0.0 1008.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSK4@1239|Firmicutes,24DXH@186801|Clostridia,3Y1DR@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04014 33035.JPJF01000057_gene3097 1.92e-300 821.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3Y12F@572511|Blautia 186801|Clostridia S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF KKPNOBBG_04015 33035.JPJF01000057_gene3096 1.01e-140 398.0 COG2860@1|root,COG2860@2|Bacteria,1UH1K@1239|Firmicutes,24HHG@186801|Clostridia,3XYJI@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 yicG - - - - - - - - - - - UPF0126 KKPNOBBG_04016 33035.JPJF01000057_gene3095 6.18e-88 259.0 COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,3Y076@572511|Blautia 186801|Clostridia S Yqey-like protein yqeY - - ko:K09117 - - - - ko00000 - - - YqeY KKPNOBBG_04017 33035.JPJF01000057_gene3094 1.24e-237 654.0 COG0451@1|root,COG0451@2|Bacteria,1TPYA@1239|Firmicutes,24A39@186801|Clostridia 186801|Clostridia GM Epimerase dehydratase - - - - - - - - - - - - Epimerase KKPNOBBG_04019 33035.JPJF01000057_gene3090 4e-168 472.0 COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia 186801|Clostridia C nitroreductase - - - - - - - - - - - - Nitroreductase KKPNOBBG_04020 1007096.BAGW01000011_gene2277 2.13e-85 257.0 COG1396@1|root,COG2033@1|root,COG1396@2|Bacteria,COG2033@2|Bacteria,1W1Q8@1239|Firmicutes,25EKH@186801|Clostridia,2N7IV@216572|Oscillospiraceae 186801|Clostridia K Desulfoferrodoxin - - - - - - - - - - - - Acetyltransf_3,Desulfoferrodox,HTH_3 KKPNOBBG_04022 33035.JPJF01000057_gene3089 1.03e-70 213.0 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia 186801|Clostridia O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin KKPNOBBG_04024 33035.JPJF01000057_gene3087 1.29e-150 424.0 COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,248YR@186801|Clostridia,3XZ71@572511|Blautia 186801|Clostridia H Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 KKPNOBBG_04025 33035.JPJF01000057_gene3086 5.33e-45 147.0 2EC7P@1|root,33668@2|Bacteria,1VHK0@1239|Firmicutes,24R0C@186801|Clostridia,3Y0UW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04026 33035.JPJF01000057_gene3085 1.94e-246 677.0 COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia,3XZ0T@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 ntpC - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 KKPNOBBG_04027 33035.JPJF01000057_gene3084 0.0 1239.0 COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3XZ9K@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score ntpI - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I KKPNOBBG_04028 33035.JPJF01000057_gene3083 8.08e-78 234.0 COG0636@1|root,COG0636@2|Bacteria,1VAGE@1239|Firmicutes,24RB6@186801|Clostridia,3Y0BA@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 9.99 - - - ko:K02124 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_C KKPNOBBG_04029 33035.JPJF01000057_gene3082 1.71e-65 199.0 COG1436@1|root,COG1436@2|Bacteria,1VEN1@1239|Firmicutes,24K2E@186801|Clostridia,3Y07R@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F KKPNOBBG_04030 33035.JPJF01000057_gene3081 1.44e-118 341.0 COG1390@1|root,COG1390@2|Bacteria,1V7UJ@1239|Firmicutes,24ICM@186801|Clostridia,3Y0B1@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - vATP-synt_E KKPNOBBG_04031 33035.JPJF01000057_gene3080 0.0 1151.0 COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,3XYVX@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit ntpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn KKPNOBBG_04032 33035.JPJF01000057_gene3079 0.0 906.0 COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,3XZA3@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit ntpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N KKPNOBBG_04033 33035.JPJF01000057_gene3078 1.09e-132 377.0 COG1394@1|root,COG1394@2|Bacteria,1TQ4P@1239|Firmicutes,24Z7J@186801|Clostridia,3XYVE@572511|Blautia 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D KKPNOBBG_04034 33035.JPJF01000057_gene3076 6.71e-174 491.0 COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,3XYMF@572511|Blautia 186801|Clostridia P COG COG0226 ABC-type phosphate transport system, periplasmic component pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 KKPNOBBG_04035 33035.JPJF01000057_gene3075 1.49e-181 507.0 COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,3XZ6A@572511|Blautia 186801|Clostridia P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 KKPNOBBG_04036 33035.JPJF01000057_gene3074 6.09e-177 496.0 COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,3XYWM@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 KKPNOBBG_04037 33035.JPJF01000057_gene3073 5.63e-176 491.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3XYGV@572511|Blautia 186801|Clostridia P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran KKPNOBBG_04038 33035.JPJF01000057_gene3072 5.76e-141 400.0 COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,3XZTS@572511|Blautia 186801|Clostridia P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU KKPNOBBG_04039 33035.JPJF01000057_gene3071 1.67e-151 427.0 COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24EFS@186801|Clostridia,3XYU2@572511|Blautia 186801|Clostridia KT Psort location Cytoplasmic, score 9.98 - - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_04040 33035.JPJF01000057_gene3070 0.0 952.0 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3XZMN@572511|Blautia 186801|Clostridia T Single Cache-like phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_like KKPNOBBG_04041 33035.JPJF01000044_gene1118 2.37e-84 255.0 COG4817@1|root,COG4817@2|Bacteria,1V8KV@1239|Firmicutes,25D3C@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1048) - - - - - - - - - - - - - KKPNOBBG_04042 33035.JPJF01000044_gene1117 3.32e-52 167.0 COG1695@1|root,COG1695@2|Bacteria,1VAGB@1239|Firmicutes,24MZ2@186801|Clostridia,3Y20G@572511|Blautia 186801|Clostridia K Transcriptional regulator PadR-like family - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR KKPNOBBG_04043 33035.JPJF01000044_gene1116 1.37e-288 790.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3XZFW@572511|Blautia 186801|Clostridia G Galactokinase galactose-binding signature galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg KKPNOBBG_04044 33035.JPJF01000044_gene1115 7.81e-208 576.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3XZ6G@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 KKPNOBBG_04045 33035.JPJF01000044_gene1114 1.48e-259 719.0 2DM0D@1|root,314WJ@2|Bacteria,1V87M@1239|Firmicutes,24JNN@186801|Clostridia,3Y15V@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04046 33035.JPJF01000044_gene1113 0.0 1110.0 COG4805@1|root,COG4805@2|Bacteria,1TREN@1239|Firmicutes,249U9@186801|Clostridia,3XYKE@572511|Blautia 186801|Clostridia S protein conserved in bacteria - - - - - - - - - - - - DUF885 KKPNOBBG_04047 33035.JPJF01000044_gene1112 1.07e-93 274.0 COG1846@1|root,COG1846@2|Bacteria,1V6GY@1239|Firmicutes,24HTB@186801|Clostridia,3Y09U@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - HTH_27,MarR,MarR_2 KKPNOBBG_04048 33035.JPJF01000044_gene1104 2.22e-155 438.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,3XYWN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 fruR - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_04049 33035.JPJF01000044_gene1103 0.0 984.0 COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,3XZ65@572511|Blautia 186801|Clostridia G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsP - 2.7.3.9,2.7.9.2 ko:K01007,ko:K08483 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C KKPNOBBG_04050 33035.JPJF01000044_gene1102 1.6e-49 157.0 COG1925@1|root,COG1925@2|Bacteria,1VE7N@1239|Firmicutes,24Q2D@186801|Clostridia,3Y0JB@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score ptsH - - - - - - - - - - - PTS-HPr KKPNOBBG_04051 33035.JPJF01000044_gene1101 0.0 1155.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1TPKU@1239|Firmicutes,248V6@186801|Clostridia,3XZB2@572511|Blautia 186801|Clostridia GT Psort location CytoplasmicMembrane, score 10.00 fruA - 2.7.1.202 ko:K02768,ko:K02769,ko:K02770 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIA_2,PTS_EIIC,PTS_IIB KKPNOBBG_04052 33035.JPJF01000044_gene1100 4.07e-192 536.0 COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia,3XZ0R@572511|Blautia 186801|Clostridia H Belongs to the carbohydrate kinase PfkB family. LacC subfamily pfkB - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB KKPNOBBG_04053 33035.JPJF01000044_gene1099 1.19e-178 503.0 COG5464@1|root,COG5464@2|Bacteria,1V2I2@1239|Firmicutes 1239|Firmicutes S transposase or invertase - - - - - - - - - - - - - KKPNOBBG_04054 33035.JPJF01000044_gene1098 4.58e-128 364.0 COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24EHP@186801|Clostridia,3Y2C4@572511|Blautia 186801|Clostridia Q Phosphate propanoyltransferase - - 2.3.1.8 ko:K15024 ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200 M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTAC KKPNOBBG_04055 33035.JPJF01000044_gene1097 1.57e-127 365.0 29UT2@1|root,30G5C@2|Bacteria,1UF7K@1239|Firmicutes,25K8E@186801|Clostridia,3Y1QV@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04056 33035.JPJF01000044_gene1096 4.53e-240 660.0 COG1063@1|root,COG1063@2|Bacteria,1TQKZ@1239|Firmicutes,24BU4@186801|Clostridia 186801|Clostridia E Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_zinc_N KKPNOBBG_04057 33035.JPJF01000044_gene1095 3.96e-230 634.0 COG0673@1|root,COG0673@2|Bacteria,1V0BK@1239|Firmicutes,24R68@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_04059 33035.JPJF01000044_gene1094 1.24e-311 849.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,3Y1J8@572511|Blautia 186801|Clostridia G Family 4 glycosyl hydrolase - - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_04060 33035.JPJF01000044_gene1093 2.76e-181 507.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,3Y0FC@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04061 33035.JPJF01000044_gene1092 2.78e-203 563.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04062 33035.JPJF01000044_gene1091 6.08e-294 805.0 COG2182@1|root,COG2182@2|Bacteria 2|Bacteria G maltose binding - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04063 33035.JPJF01000044_gene1090 5.08e-180 503.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_04064 33035.JPJF01000044_gene1089 1.45e-67 205.0 COG0140@1|root,COG0140@2|Bacteria,1VB6S@1239|Firmicutes,24MP1@186801|Clostridia 186801|Clostridia E Phosphoribosyl-ATP hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH KKPNOBBG_04065 33035.JPJF01000044_gene1088 2.33e-62 192.0 COG0139@1|root,COG0139@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,3XZDT@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS05760 His_biosynth,PRA-CH,PRA-PH KKPNOBBG_04066 33035.JPJF01000044_gene1087 6.58e-175 488.0 COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,3XZ31@572511|Blautia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS05755 His_biosynth KKPNOBBG_04067 33035.JPJF01000044_gene1086 1.34e-148 421.0 COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia 186801|Clostridia E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth KKPNOBBG_04068 33035.JPJF01000044_gene1085 2.72e-135 384.0 COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,3XZAS@572511|Blautia 186801|Clostridia E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase KKPNOBBG_04069 33035.JPJF01000044_gene1084 1.12e-130 371.0 COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,3XYJ4@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD KKPNOBBG_04070 33035.JPJF01000044_gene1083 4.8e-231 638.0 COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3XYHE@572511|Blautia 186801|Clostridia E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_04071 33035.JPJF01000044_gene1082 8.65e-144 406.0 COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,3XZ1U@572511|Blautia 186801|Clostridia H Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG KKPNOBBG_04072 33035.JPJF01000044_gene1081 9.81e-288 786.0 COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia,3XYWI@572511|Blautia 186801|Clostridia E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His KKPNOBBG_04073 33035.JPJF01000044_gene1080 0.0 1118.0 COG0642@1|root,COG0642@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,3Y28B@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg,SBP_bac_3 KKPNOBBG_04074 33035.JPJF01000044_gene1079 1.39e-106 308.0 COG0700@1|root,COG0700@2|Bacteria,1V45M@1239|Firmicutes,24HSJ@186801|Clostridia,3Y01E@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 spmB - - ko:K06374 - - - - ko00000 - - - Gate KKPNOBBG_04075 33035.JPJF01000044_gene1078 7.04e-305 833.0 COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,249Q3@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - - - - - - - - - - MatE KKPNOBBG_04076 33035.JPJF01000044_gene1077 3.71e-208 577.0 COG1209@1|root,COG1209@2|Bacteria,1TPR2@1239|Firmicutes,2490F@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - NTP_transferase KKPNOBBG_04077 33035.JPJF01000044_gene1076 2.26e-250 689.0 COG2334@1|root,COG2334@2|Bacteria,1UXS1@1239|Firmicutes,25MC4@186801|Clostridia,3XZ7J@572511|Blautia 2|Bacteria M Psort location Cytoplasmic, score 8.87 mdsC - 2.7.1.162,2.7.1.39 ko:K02204,ko:K13059 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771,R08962 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - APH KKPNOBBG_04078 33035.JPJF01000044_gene1075 4.13e-189 526.0 COG2207@1|root,COG2207@2|Bacteria,1V59G@1239|Firmicutes,24KRI@186801|Clostridia,3Y26X@572511|Blautia 186801|Clostridia K Sensory domain found in PocR - - - - - - - - - - - - HTH_18,HTH_AraC,PocR KKPNOBBG_04079 33035.JPJF01000044_gene1074 6.41e-113 326.0 COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,3XZUW@572511|Blautia 186801|Clostridia P Chromate transporter - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp KKPNOBBG_04080 33035.JPJF01000044_gene1073 6.25e-107 312.0 COG2059@1|root,COG2059@2|Bacteria,1V22C@1239|Firmicutes,24G7P@186801|Clostridia,3XZU9@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp KKPNOBBG_04081 33035.JPJF01000044_gene1072 9.78e-168 473.0 COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,3Y0C6@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04082 33035.JPJF01000147_gene1792 4.92e-208 585.0 COG0760@1|root,COG0760@2|Bacteria,1V1WU@1239|Firmicutes,24G3V@186801|Clostridia,3Y03A@572511|Blautia 186801|Clostridia O PPIC-type PPIASE domain - - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,SurA_N_3 KKPNOBBG_04083 33035.JPJF01000147_gene1791 0.0 2199.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3XZME@572511|Blautia 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF KKPNOBBG_04084 33035.JPJF01000147_gene1790 1.26e-130 371.0 COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3XYSI@572511|Blautia 186801|Clostridia J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro KKPNOBBG_04085 33035.JPJF01000147_gene1789 1.13e-223 617.0 COG0523@1|root,COG3689@1|root,COG0523@2|Bacteria,COG3689@2|Bacteria,1TS8P@1239|Firmicutes,248DY@186801|Clostridia,3XZGD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - cobW KKPNOBBG_04086 537007.BLAHAN_07064 2.72e-172 493.0 COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248XD@186801|Clostridia,3XYNY@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 cobW - - - - - - - - - - - CobW_C,cobW KKPNOBBG_04087 180332.JTGN01000002_gene5639 1.04e-245 717.0 COG0577@1|root,COG0577@2|Bacteria,1TV1M@1239|Firmicutes,24E2X@186801|Clostridia 186801|Clostridia V Efflux ABC transporter, permease protein - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_04088 411470.RUMGNA_03563 2.23e-121 351.0 COG1136@1|root,COG1136@2|Bacteria,1UUUX@1239|Firmicutes,25KAJ@186801|Clostridia,3Y12W@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_04089 556261.HMPREF0240_02302 5.23e-111 330.0 COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia,36W9P@31979|Clostridiaceae 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_04090 1226325.HMPREF1548_04051 3.72e-87 264.0 COG0745@1|root,COG0745@2|Bacteria,1V1ZV@1239|Firmicutes,24GM1@186801|Clostridia,36IMV@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_04091 33035.JPJF01000062_gene3611 0.0 902.0 COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,3Y0D2@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 10.00 nhaC - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter KKPNOBBG_04092 33035.JPJF01000062_gene3612 1.6e-194 541.0 COG2421@1|root,COG2421@2|Bacteria,1TQ67@1239|Firmicutes,24ZE8@186801|Clostridia,3Y1PE@572511|Blautia 186801|Clostridia C Acetamidase/Formamidase family - - - - - - - - - - - - FmdA_AmdA KKPNOBBG_04093 33035.JPJF01000062_gene3613 5.03e-277 760.0 COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3XZ14@572511|Blautia 186801|Clostridia E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23,1.1.1.308 ko:K00013,ko:K15509 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_1_2,Histidinol_dh KKPNOBBG_04094 33035.JPJF01000062_gene3614 2.44e-235 652.0 COG0789@1|root,COG0789@2|Bacteria,1V12J@1239|Firmicutes,24DI4@186801|Clostridia 186801|Clostridia K regulatory protein MerR - - - - - - - - - - - - MerR_1,Methyltransf_25,Methyltransf_31 KKPNOBBG_04095 33035.JPJF01000062_gene3616 6.69e-250 686.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,248TR@186801|Clostridia,3XZ15@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase KKPNOBBG_04096 33035.JPJF01000062_gene3617 1.1e-183 514.0 COG2207@1|root,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,24I3P@186801|Clostridia,3Y1VY@572511|Blautia 186801|Clostridia K Cupin domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_04097 33035.JPJF01000062_gene3618 0.0 1337.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia,3Y2CQ@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 31 - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31 KKPNOBBG_04098 33035.JPJF01000062_gene3619 3.82e-316 860.0 COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,247JE@186801|Clostridia,3XZM9@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM KKPNOBBG_04099 33035.JPJF01000062_gene3620 9.12e-29 103.0 COG2104@1|root,COG2104@2|Bacteria,1VKB4@1239|Firmicutes,25HV0@186801|Clostridia,3Y0TI@572511|Blautia 186801|Clostridia H ThiS family - - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS KKPNOBBG_04100 33035.JPJF01000062_gene3621 3.04e-128 367.0 COG0476@1|root,COG0476@2|Bacteria,1UYFC@1239|Firmicutes,247UZ@186801|Clostridia,3Y1J5@572511|Blautia 186801|Clostridia H ThiF family thiF - 2.7.7.73 ko:K03148 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF,ThiS-like KKPNOBBG_04101 33035.JPJF01000062_gene3622 4.68e-163 458.0 COG2022@1|root,COG2022@2|Bacteria,1TQZ1@1239|Firmicutes,247TJ@186801|Clostridia,3XZG0@572511|Blautia 186801|Clostridia H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG KKPNOBBG_04102 33035.JPJF01000062_gene3623 3.5e-249 687.0 COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,3XYRP@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 thiH - 4.1.99.19 ko:K03150 ko00730,ko01100,map00730,map01100 - R10246 RC01434,RC03095 ko00000,ko00001,ko01000 - - - BATS,Radical_SAM KKPNOBBG_04103 33035.JPJF01000062_gene3624 9.92e-86 258.0 COG0352@1|root,COG0352@2|Bacteria,1V4SE@1239|Firmicutes,24JTR@186801|Clostridia,3Y00P@572511|Blautia 186801|Clostridia H Thiamine monophosphate synthase tenI - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06600 TMP-TENI KKPNOBBG_04104 33035.JPJF01000062_gene3625 1.51e-193 542.0 COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,3Y005@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 KKPNOBBG_04105 1408311.JNJM01000001_gene308 1.21e-91 314.0 COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,2PTD1@265975|Oribacterium 186801|Clostridia M RHS Repeat - - - - - - - - - - - - DUF4280,RHS_repeat KKPNOBBG_04106 1121864.OMO_01631 0.0 1224.0 COG1961@1|root,COG1961@2|Bacteria,1TP0S@1239|Firmicutes,4HBBX@91061|Bacilli,4B6EH@81852|Enterococcaceae 91061|Bacilli L Domain of unknown function (DUF4368) - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_04107 1121864.OMO_01632 4.17e-55 172.0 2AH2U@1|root,317C4@2|Bacteria,1V7XU@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_04108 1121864.OMO_01633 1.99e-48 154.0 COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,4HNSP@91061|Bacilli 91061|Bacilli S protein conserved in bacteria XK26_06125 - - - - - - - - - - - PC4 KKPNOBBG_04109 1123489.AUAN01000007_gene422 7.99e-192 533.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,4H7H6@909932|Negativicutes 909932|Negativicutes K ParB-like nuclease domain - - - - - - - - - - - - ParBc KKPNOBBG_04110 1121864.OMO_01635 9.01e-228 627.0 COG1196@1|root,COG1196@2|Bacteria,1TRNI@1239|Firmicutes,4HHXH@91061|Bacilli,4B4B0@81852|Enterococcaceae 91061|Bacilli D Plasmid recombination enzyme XK26_06135 - - - - - - - - - - - Mob_Pre KKPNOBBG_04111 1121864.OMO_01636 2.03e-250 686.0 COG0468@1|root,COG0468@2|Bacteria,1V9SB@1239|Firmicutes 1239|Firmicutes L Psort location Cytoplasmic, score 8.87 XK27_03350 - - - - - - - - - - - AAA_25 KKPNOBBG_04112 1232452.BAIB02000011_gene2185 4.37e-32 111.0 2EF0F@1|root,338TI@2|Bacteria,1VHS7@1239|Firmicutes,24TZ5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04113 1121864.OMO_01638 7.15e-95 276.0 COG1595@1|root,COG1595@2|Bacteria,1UYSW@1239|Firmicutes 1239|Firmicutes K Psort location Cytoplasmic, score 8.87 - - - ko:K03088 - - - - ko00000,ko03021 - - - - KKPNOBBG_04114 1121864.OMO_01639 6.96e-116 332.0 COG1191@1|root,COG1191@2|Bacteria,1V1GF@1239|Firmicutes 1239|Firmicutes K Psort location Cytoplasmic, score XK26_06155 - - - - - - - - - - - Sigma70_r4 KKPNOBBG_04115 1121864.OMO_01640 0.0 1272.0 COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,4HAS9@91061|Bacilli,4B0A2@81852|Enterococcaceae 91061|Bacilli J Elongation factor G, domain IV tetM - - ko:K18220 - - - - br01600,ko00000,ko01504 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU KKPNOBBG_04116 1121864.OMO_01641 2.34e-85 251.0 2C5R4@1|root,2ZC1N@2|Bacteria,1V292@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TnpV KKPNOBBG_04117 140626.JHWB01000010_gene1893 1.27e-12 81.6 COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia 186801|Clostridia M RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat KKPNOBBG_04119 397291.C804_00363 6.53e-33 117.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding ramB GO:0001666,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006629,GO:0006631,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016999,GO:0017144,GO:0019219,GO:0019222,GO:0019541,GO:0019679,GO:0019752,GO:0031323,GO:0031326,GO:0032787,GO:0036293,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046459,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070482,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K07110,ko:K21686,ko:K22300 - - - - ko00000,ko03000 - - - DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78 KKPNOBBG_04120 929712.KI912613_gene1133 3.67e-09 60.8 COG1716@1|root,COG1716@2|Bacteria,2HM1E@201174|Actinobacteria,4CQ7B@84995|Rubrobacteria 84995|Rubrobacteria T Forkhead associated domain - - - - - - - - - - - - FHA KKPNOBBG_04121 693746.OBV_34240 2.72e-15 73.2 COG4842@1|root,COG4842@2|Bacteria 2|Bacteria S protein secretion by the type VII secretion system - - - - - - - - - - - - WXG100 KKPNOBBG_04125 1410626.JHXB01000004_gene221 6.38e-21 87.0 COG4842@1|root,COG4842@2|Bacteria,1VGZJ@1239|Firmicutes,24QQC@186801|Clostridia,27PX2@186928|unclassified Lachnospiraceae 186801|Clostridia S Proteins of 100 residues with WXG - - - - - - - - - - - - WXG100 KKPNOBBG_04126 1408311.JNJM01000001_gene314 2.47e-25 97.8 COG4842@1|root,COG4842@2|Bacteria,1VMRT@1239|Firmicutes,24URX@186801|Clostridia 186801|Clostridia S Proteins of 100 residues with WXG - - - - - - - - - - - - WXG100 KKPNOBBG_04127 1095750.HMPREF9970_0769 1.29e-10 59.3 2BH28@1|root,32B2T@2|Bacteria,1VQDM@1239|Firmicutes,25PPA@186801|Clostridia,1HWEV@1164882|Lachnoanaerobaculum 186801|Clostridia S WXG100 protein secretion system (Wss), protein YukD - - - - - - - - - - - - YukD KKPNOBBG_04129 1235802.C823_03152 2.37e-51 174.0 COG3279@1|root,COG3279@2|Bacteria,1VD3A@1239|Firmicutes,24MP2@186801|Clostridia,25YVR@186806|Eubacteriaceae 186801|Clostridia K LytTr DNA-binding domain - - - - - - - - - - - - LytTR KKPNOBBG_04130 1410628.JNKS01000001_gene2471 0.0 1519.0 COG0433@1|root,COG1674@1|root,COG1716@1|root,COG0433@2|Bacteria,COG1674@2|Bacteria,COG1716@2|Bacteria,1TRA4@1239|Firmicutes,249Z1@186801|Clostridia,27I5U@186928|unclassified Lachnospiraceae 186801|Clostridia D FtsK/SpoIIIE family essC - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FHA,FtsK_SpoIIIE KKPNOBBG_04132 665950.HMPREF1025_01631 3.21e-107 337.0 COG4676@1|root,COG4676@2|Bacteria,1VF8Z@1239|Firmicutes,24S72@186801|Clostridia,27PHZ@186928|unclassified Lachnospiraceae 186801|Clostridia S Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,TPR_11 KKPNOBBG_04135 665950.HMPREF1025_01633 1.7e-135 417.0 COG0515@1|root,COG0515@2|Bacteria,1TPYP@1239|Firmicutes,24ABN@186801|Clostridia,27IAE@186928|unclassified Lachnospiraceae 186801|Clostridia KLT Protein tyrosine kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16 KKPNOBBG_04136 665950.HMPREF1025_01634 1.03e-217 728.0 COG3188@1|root,COG3188@2|Bacteria,1TPTP@1239|Firmicutes,2490I@186801|Clostridia,27KPF@186928|unclassified Lachnospiraceae 186801|Clostridia NU Bacterial Ig-like domain (group 3) - - - - - - - - - - - - Big_3_2,Big_3_3 KKPNOBBG_04139 665950.HMPREF1025_01637 2.87e-232 661.0 COG0515@1|root,COG0515@2|Bacteria,1TPYP@1239|Firmicutes,24ABN@186801|Clostridia,27IE6@186928|unclassified Lachnospiraceae 186801|Clostridia KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase KKPNOBBG_04140 665950.HMPREF1025_01638 1.02e-95 288.0 COG0631@1|root,COG0631@2|Bacteria,1V2F5@1239|Firmicutes,24KFQ@186801|Clostridia,27KK6@186928|unclassified Lachnospiraceae 186801|Clostridia T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 KKPNOBBG_04141 411460.RUMTOR_02256 1.17e-82 275.0 COG0265@1|root,COG1716@1|root,COG0265@2|Bacteria,COG1716@2|Bacteria,1UVFK@1239|Firmicutes,25MV4@186801|Clostridia,3Y248@572511|Blautia 186801|Clostridia T Forkhead associated domain - - - - - - - - - - - - FHA KKPNOBBG_04142 33035.JPJF01000062_gene3626 0.0 1294.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3XYYD@572511|Blautia 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 KKPNOBBG_04143 33035.JPJF01000062_gene3627 0.0 899.0 COG0366@1|root,COG0366@2|Bacteria,1TQFJ@1239|Firmicutes,249Y3@186801|Clostridia,3XZH5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.2.1.133,3.2.1.135,3.2.1.54,3.5.4.33 ko:K01208,ko:K11991 ko00500,ko01100,map00500,map01100 - R02112,R03122,R10223,R11262 RC00477 ko00000,ko00001,ko01000,ko03016 - GH13 - Alpha-amylase,Alpha-amylase_C,DUF1653,Malt_amylase_C KKPNOBBG_04144 33035.JPJF01000062_gene3628 1.09e-132 377.0 COG1309@1|root,COG1309@2|Bacteria,1V5H6@1239|Firmicutes,24ITS@186801|Clostridia,3Y1HI@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_04145 33035.JPJF01000062_gene3629 4.44e-174 486.0 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,3XZFC@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase KKPNOBBG_04146 33035.JPJF01000062_gene3630 3.42e-221 616.0 COG0628@1|root,COG0628@2|Bacteria,1TQBF@1239|Firmicutes,25CCK@186801|Clostridia,3XYVI@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - AI-2E_transport KKPNOBBG_04147 33035.JPJF01000062_gene3631 0.0 1582.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3XZ58@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase KKPNOBBG_04148 33035.JPJF01000062_gene3632 2.41e-121 348.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,3XZYR@572511|Blautia 186801|Clostridia S Maltose acetyltransferase - - - - - - - - - - - - Hexapep,Hexapep_2,Mac KKPNOBBG_04149 33035.JPJF01000062_gene3634 9.75e-173 484.0 COG2365@1|root,COG2365@2|Bacteria,1V851@1239|Firmicutes,24GVA@186801|Clostridia,3XZNA@572511|Blautia 186801|Clostridia T Tyrosine phosphatase family - - - - - - - - - - - - Y_phosphatase3 KKPNOBBG_04150 33035.JPJF01000062_gene3635 0.0 2056.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,3XYIU@572511|Blautia 186801|Clostridia G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_04151 33035.JPJF01000062_gene3636 1.62e-193 537.0 COG2207@1|root,COG2207@2|Bacteria,1TR2K@1239|Firmicutes,24ABH@186801|Clostridia,3Y03Y@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain araC_2 - - ko:K02099 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_04152 33035.JPJF01000062_gene3637 1.79e-167 472.0 COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia,3XYUH@572511|Blautia 186801|Clostridia G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion - - - - - - - - - - - - Glucosamine_iso KKPNOBBG_04153 33035.JPJF01000062_gene3638 1.04e-165 466.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3XZXP@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04154 33035.JPJF01000062_gene3639 8.31e-184 513.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XZUR@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04155 33035.JPJF01000062_gene3640 1.54e-305 835.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,3Y0HZ@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04156 33035.JPJF01000062_gene3641 2.88e-208 579.0 COG2971@1|root,COG2971@2|Bacteria,1V0YJ@1239|Firmicutes,24YAU@186801|Clostridia 186801|Clostridia G BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG KKPNOBBG_04157 33035.JPJF01000062_gene3642 2.5e-296 809.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia 186801|Clostridia G family 4 - - 3.2.1.86 ko:K01222 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_04158 33035.JPJF01000062_gene3643 2.76e-225 622.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,3Y0DN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 9.98 - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_04159 411459.RUMOBE_00395 3.55e-54 175.0 COG1595@1|root,COG1595@2|Bacteria,1UZSS@1239|Firmicutes,24GQJ@186801|Clostridia 186801|Clostridia K Belongs to the sigma-70 factor family. ECF subfamily - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_04161 33035.JPJF01000062_gene3644 0.0 1287.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,3XYH1@572511|Blautia 186801|Clostridia J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind KKPNOBBG_04162 33035.JPJF01000062_gene3646 1.62e-81 242.0 2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,3Y1UV@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - Cytochrom_B561 KKPNOBBG_04163 33035.JPJF01000062_gene3648 0.0 866.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,3XZU5@572511|Blautia 186801|Clostridia G COG COG2211 Na melibiose symporter and related transporters gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_04164 33035.JPJF01000062_gene3649 1.89e-225 620.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,24ECM@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_04165 33035.JPJF01000062_gene3650 6.82e-223 614.0 COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia 186801|Clostridia G TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N KKPNOBBG_04166 33035.JPJF01000062_gene3651 3.76e-290 791.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,24AR9@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04167 33035.JPJF01000062_gene3652 8.69e-160 450.0 COG2207@1|root,COG2207@2|Bacteria,1UUUM@1239|Firmicutes,25KCJ@186801|Clostridia,3Y1WS@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_04168 33035.JPJF01000062_gene3653 2.09e-45 146.0 COG1925@1|root,COG1925@2|Bacteria,1URTV@1239|Firmicutes,259R8@186801|Clostridia,3Y261@572511|Blautia 186801|Clostridia G phosphoenolpyruvate-dependent sugar phosphotransferase system - - - - - - - - - - - - - KKPNOBBG_04169 33035.JPJF01000062_gene3655 2.68e-166 469.0 COG5464@1|root,COG5464@2|Bacteria,1TPB1@1239|Firmicutes,24B0D@186801|Clostridia,3Y1C0@572511|Blautia 186801|Clostridia S COG NOG17660 non supervised orthologous group - - - - - - - - - - - - PDDEXK_2 KKPNOBBG_04170 33035.JPJF01000062_gene3655 9.13e-169 476.0 COG5464@1|root,COG5464@2|Bacteria,1TPB1@1239|Firmicutes,24B0D@186801|Clostridia,3Y1C0@572511|Blautia 186801|Clostridia S COG NOG17660 non supervised orthologous group - - - - - - - - - - - - PDDEXK_2 KKPNOBBG_04171 33035.JPJF01000035_gene3475 0.0 1425.0 COG3345@1|root,COG3345@2|Bacteria,1TSZB@1239|Firmicutes,247VV@186801|Clostridia 186801|Clostridia G alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase KKPNOBBG_04172 33035.JPJF01000035_gene3476 3.48e-168 473.0 COG0395@1|root,COG0395@2|Bacteria,1TRXW@1239|Firmicutes,25C4N@186801|Clostridia,3XZGR@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04173 33035.JPJF01000035_gene3477 3.22e-216 597.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04174 33035.JPJF01000101_gene3243 1.36e-79 236.0 COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,3Y043@572511|Blautia 186801|Clostridia J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 KKPNOBBG_04175 33035.JPJF01000101_gene3242 1.81e-76 229.0 COG0100@1|root,COG0100@2|Bacteria,1V3IK@1239|Firmicutes,24HIK@186801|Clostridia,3XZVK@572511|Blautia 186801|Clostridia J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 KKPNOBBG_04176 33035.JPJF01000101_gene3241 3.33e-134 380.0 COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,3XYWU@572511|Blautia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 KKPNOBBG_04177 537007.BLAHAN_06351 7.78e-212 587.0 COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3XYUC@572511|Blautia 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L KKPNOBBG_04178 33035.JPJF01000101_gene3239 7.59e-113 325.0 COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,3XZ2H@572511|Blautia 186801|Clostridia J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 KKPNOBBG_04179 33035.JPJF01000101_gene3237 1.04e-214 593.0 COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,3XYYK@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 dagK - - - - - - - - - - - DAGK_cat KKPNOBBG_04180 33035.JPJF01000101_gene3236 1.41e-115 332.0 COG1971@1|root,COG1971@2|Bacteria,1V25U@1239|Firmicutes,25CUT@186801|Clostridia,3Y0VM@572511|Blautia 186801|Clostridia P Putative manganese efflux pump ytaF - - - - - - - - - - - Mntp KKPNOBBG_04181 33035.JPJF01000101_gene3235 0.0 1372.0 COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3XZDZ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C KKPNOBBG_04182 33035.JPJF01000101_gene3234 7.93e-219 603.0 COG0714@1|root,COG0714@2|Bacteria,1TQJA@1239|Firmicutes,249C6@186801|Clostridia,3XYS0@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - AAA_5 KKPNOBBG_04183 33035.JPJF01000101_gene3233 0.0 1120.0 COG4548@1|root,COG4548@2|Bacteria,1TS8V@1239|Firmicutes,249FH@186801|Clostridia,3XZDU@572511|Blautia 186801|Clostridia P NorD protein required for nitric oxide reductase (Nor) activity - - - - - - - - - - - - CobT_C KKPNOBBG_04184 33035.JPJF01000049_gene576 3.43e-259 712.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3XZS4@572511|Blautia 186801|Clostridia J tRNA (Uracil-5-)-methyltransferase rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr KKPNOBBG_04186 457421.CBFG_03572 1.43e-168 476.0 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,26863@186813|unclassified Clostridiales 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04187 457421.CBFG_03573 6.34e-72 217.0 COG0789@1|root,COG0789@2|Bacteria,1V792@1239|Firmicutes,24K0X@186801|Clostridia,26963@186813|unclassified Clostridiales 186801|Clostridia K MerR HTH family regulatory protein - - - - - - - - - - - - MerR_1 KKPNOBBG_04188 457421.CBFG_03574 2.61e-118 343.0 COG0716@1|root,COG0716@2|Bacteria,1V3ZD@1239|Firmicutes,24HQG@186801|Clostridia,26B6V@186813|unclassified Clostridiales 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4 KKPNOBBG_04189 457421.CBFG_03575 0.0 1008.0 COG0716@1|root,COG1262@1|root,COG0716@2|Bacteria,COG1262@2|Bacteria,1UVQ2@1239|Firmicutes,25KKQ@186801|Clostridia,26BNV@186813|unclassified Clostridiales 186801|Clostridia C Flavodoxin - - - - - - - - - - - - Flavodoxin_4 KKPNOBBG_04191 457421.CBFG_03579 8.93e-221 613.0 COG1073@1|root,COG1073@2|Bacteria,1TPW7@1239|Firmicutes,24A5B@186801|Clostridia,268AH@186813|unclassified Clostridiales 186801|Clostridia S Dienelactone hydrolase family - - - ko:K06889 - - - - ko00000 - - - AXE1,DLH,Peptidase_S15 KKPNOBBG_04192 537013.CLOSTMETH_01280 6.43e-102 299.0 COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,3WJ1H@541000|Ruminococcaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red KKPNOBBG_04193 1507.HMPREF0262_02799 1e-52 167.0 COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia,36JJV@31979|Clostridiaceae 186801|Clostridia K regulatory protein, arsR arsR - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 KKPNOBBG_04194 742741.HMPREF9475_04121 1.87e-196 549.0 COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,21YUB@1506553|Lachnoclostridium 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07089 - - - - ko00000 - - - ArsP_1 KKPNOBBG_04195 742735.HMPREF9467_05120 2.37e-29 112.0 COG0175@1|root,COG0175@2|Bacteria,1TSMI@1239|Firmicutes,24A18@186801|Clostridia,220A1@1506553|Lachnoclostridium 186801|Clostridia EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct KKPNOBBG_04196 397287.C807_01206 1.17e-39 135.0 2DZDJ@1|root,32V7X@2|Bacteria,1VED8@1239|Firmicutes,24PBC@186801|Clostridia,27Q7P@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04198 457421.CBFG_00175 1.37e-91 270.0 COG1670@1|root,COG1670@2|Bacteria,1V4F3@1239|Firmicutes,24EZ6@186801|Clostridia 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 KKPNOBBG_04199 33035.JPJF01000049_gene578 5.12e-276 779.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia 186801|Clostridia NT methyl-accepting chemotaxis protein - - - - - - - - - - - - HAMP,MCPsignal,dCache_1 KKPNOBBG_04200 33035.JPJF01000049_gene579 0.0 1365.0 COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg KKPNOBBG_04201 33035.JPJF01000049_gene583 5.37e-252 694.0 COG1453@1|root,COG1453@2|Bacteria,1TPBG@1239|Firmicutes,2497N@186801|Clostridia,3Y0YA@572511|Blautia 186801|Clostridia S 4Fe-4S dicluster domain - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 KKPNOBBG_04202 33035.JPJF01000049_gene584 0.0 1437.0 COG0642@1|root,COG0834@1|root,COG0642@2|Bacteria,COG0834@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,3Y102@572511|Blautia 186801|Clostridia T Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - HATPase_c,HisKA,Response_reg,SBP_bac_3 KKPNOBBG_04204 33035.JPJF01000049_gene585 2.06e-144 407.0 COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,3XZP9@572511|Blautia 186801|Clostridia L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD KKPNOBBG_04205 33035.JPJF01000049_gene587 0.0 1016.0 COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,24CZV@186801|Clostridia 186801|Clostridia E Transglutaminase-like - - - - - - - - - - - - DUF4129,Transglut_core KKPNOBBG_04206 33035.JPJF01000049_gene588 6.73e-230 636.0 COG1721@1|root,COG1721@2|Bacteria,1VA48@1239|Firmicutes,24CY3@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 KKPNOBBG_04207 33035.JPJF01000049_gene589 3.49e-200 557.0 COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,3XYTD@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 9.98 - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 KKPNOBBG_04208 33035.JPJF01000049_gene590 3.91e-206 573.0 COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,3Y086@572511|Blautia 186801|Clostridia S Prolyl oligopeptidase family - - - ko:K06889 - - - - ko00000 - - - DLH,FSH1,Hydrolase_4 KKPNOBBG_04209 33035.JPJF01000049_gene591 1.41e-152 431.0 COG1922@1|root,COG1922@2|Bacteria,1V7RM@1239|Firmicutes,24HC8@186801|Clostridia,3Y0VT@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - 2.4.1.187 ko:K05946 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003 - GT26 - Glyco_tran_WecB KKPNOBBG_04210 33035.JPJF01000049_gene592 3.86e-193 538.0 COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,25CBM@186801|Clostridia,3Y2EM@572511|Blautia 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2179) - - - - - - - - - - - - DUF2179,YitT_membrane KKPNOBBG_04211 33035.JPJF01000049_gene593 7.37e-256 702.0 COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia,3XYND@572511|Blautia 186801|Clostridia QT Psort location Cytoplasmic, score 8.87 cdaR_3 - - ko:K02647 - - - - ko00000,ko03000 - - - HTH_30 KKPNOBBG_04212 33035.JPJF01000049_gene594 1.96e-155 437.0 COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,3XYQ6@572511|Blautia 186801|Clostridia D Psort location CytoplasmicMembrane, score ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran KKPNOBBG_04213 33035.JPJF01000049_gene595 3.64e-172 484.0 COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,3XZN5@572511|Blautia 186801|Clostridia D Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation ftsX - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX KKPNOBBG_04214 33035.JPJF01000049_gene596 2.49e-259 713.0 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,3XZBV@572511|Blautia 186801|Clostridia M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 KKPNOBBG_04215 33035.JPJF01000049_gene597 5.68e-193 536.0 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,3XZ39@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DegV KKPNOBBG_04216 33035.JPJF01000049_gene598 1.91e-239 659.0 COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia 186801|Clostridia T Response regulator containing a CheY-like receiver domain and an HD-GYP domain - - - ko:K07814 - - - - ko00000,ko02022 - - - GGDEF,HD,HD_5,Response_reg KKPNOBBG_04217 33035.JPJF01000049_gene599 7.87e-219 605.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1TS6T@1239|Firmicutes,247QK@186801|Clostridia,3XZK6@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 KKPNOBBG_04218 33035.JPJF01000049_gene600 4.97e-294 807.0 COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,247ZU@186801|Clostridia,3XYNN@572511|Blautia 186801|Clostridia H FGGY family of carbohydrate kinases, C-terminal domain rhaB - 2.7.1.5 ko:K00848 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_04219 33035.JPJF01000049_gene601 1.2e-301 822.0 COG4806@1|root,COG4806@2|Bacteria,1TS42@1239|Firmicutes,2487G@186801|Clostridia,3Y1E8@572511|Blautia 186801|Clostridia G L-rhamnose isomerase (RhaA) rhaA - 5.3.1.14 ko:K01813 ko00051,ko01120,map00051,map01120 - R02437 RC00434 ko00000,ko00001,ko01000 - - - RhaA KKPNOBBG_04220 33035.JPJF01000049_gene602 3.18e-198 549.0 COG0235@1|root,COG0235@2|Bacteria,1TRMG@1239|Firmicutes,24BBT@186801|Clostridia,3XZSF@572511|Blautia 186801|Clostridia G Class II Aldolase and Adducin N-terminal domain rhaD - 4.1.2.19 ko:K01629 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01785,R02263 RC00438,RC00599,RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II KKPNOBBG_04221 1232447.BAHW02000049_gene3017 1.41e-129 377.0 COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24A5W@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 KKPNOBBG_04222 1232447.BAHW02000049_gene3019 8.37e-206 571.0 COG1082@1|root,COG1082@2|Bacteria,1VCQ8@1239|Firmicutes,24YST@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_04223 1232447.BAHW02000049_gene3020 8.46e-264 724.0 COG0673@1|root,COG0673@2|Bacteria,1UZEK@1239|Firmicutes,24AR9@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04224 33035.JPJF01000098_gene1762 2.77e-219 605.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,24ECM@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_04225 1232447.BAHW02000049_gene3022 1.73e-263 730.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_04226 33035.JPJF01000049_gene603 0.0 1794.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,3Y1DS@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_9,Response_reg,SnoaL_3 KKPNOBBG_04227 33035.JPJF01000049_gene604 3.91e-245 673.0 COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,25KD4@186801|Clostridia,3Y1KW@572511|Blautia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_04228 33035.JPJF01000049_gene605 1.85e-215 595.0 COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,3Y0CU@572511|Blautia 186801|Clostridia S Uncharacterised conserved protein (DUF2156) - - - ko:K01163 - - - - ko00000 - - - DUF2156 KKPNOBBG_04229 33035.JPJF01000049_gene606 2.35e-179 508.0 COG4552@1|root,COG4552@2|Bacteria,1V7PR@1239|Firmicutes,24A86@186801|Clostridia,3Y090@572511|Blautia 186801|Clostridia S acetyltransferase involved in intracellular survival and related acetyltransferases - - - - - - - - - - - - Acetyltransf_9,SCP2_2 KKPNOBBG_04230 33035.JPJF01000049_gene607 8.02e-84 248.0 COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,3Y225@572511|Blautia 186801|Clostridia C Desulfoferrodoxin - - 1.15.1.2 ko:K05919 - - - - ko00000,ko01000 - - - Desulfoferrod_N,Desulfoferrodox KKPNOBBG_04231 33035.JPJF01000049_gene608 2.46e-249 686.0 COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia 186801|Clostridia C oxidoreductase gamma subunit - - 1.2.7.1 ko:K00172 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,POR KKPNOBBG_04232 33035.JPJF01000049_gene609 0.0 1378.0 COG0674@1|root,COG1013@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K00169,ko:K00170 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N,TPP_enzyme_C KKPNOBBG_04233 33035.JPJF01000049_gene610 2.73e-197 550.0 COG0530@1|root,COG0530@2|Bacteria,1TRX0@1239|Firmicutes,24ABZ@186801|Clostridia,3XZSP@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex KKPNOBBG_04234 180332.JTGN01000005_gene2977 8.2e-206 575.0 COG1609@1|root,COG1609@2|Bacteria,1UYM8@1239|Firmicutes,24BYD@186801|Clostridia 186801|Clostridia K helix_turn _helix lactose operon repressor - - - - - - - - - - - - LacI,Peripla_BP_3 KKPNOBBG_04235 180332.JTGN01000005_gene2975 1.57e-231 643.0 COG1653@1|root,COG1653@2|Bacteria,1V10D@1239|Firmicutes,24EK2@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_04236 180332.JTGN01000005_gene2974 9.09e-164 462.0 COG1175@1|root,COG1175@2|Bacteria 2|Bacteria P transmembrane transport - - - ko:K02025,ko:K15771 ko02010,map02010 M00207,M00491 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.2 - - BPD_transp_1 KKPNOBBG_04237 180332.JTGN01000005_gene2973 7.58e-175 491.0 COG0395@1|root,COG0395@2|Bacteria,1TRUD@1239|Firmicutes,24CGW@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04238 180332.JTGN01000005_gene2972 2.13e-305 840.0 COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 KKPNOBBG_04239 33035.JPJF01000055_gene1702 1.61e-284 786.0 COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,3Y0TG@572511|Blautia 186801|Clostridia G Alpha-L-arabinofuranosidase C-terminal domain - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C KKPNOBBG_04240 553973.CLOHYLEM_04616 1.88e-204 582.0 COG2186@1|root,COG2188@1|root,COG2186@2|Bacteria,COG2188@2|Bacteria,1V12R@1239|Firmicutes,24QFG@186801|Clostridia,2245X@1506553|Lachnoclostridium 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_04241 457421.CBFG_05657 0.0 1263.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,268VW@186813|unclassified Clostridiales 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg KKPNOBBG_04242 1123075.AUDP01000022_gene3621 1.08e-244 695.0 COG4905@1|root,COG5523@1|root,COG4905@2|Bacteria,COG5523@2|Bacteria,1TQHG@1239|Firmicutes,2485W@186801|Clostridia,3WP0S@541000|Ruminococcaceae 186801|Clostridia S Protein of unknown function (DUF975) - - - - - - - - - - - - ABC_trans_CmpB,DUF975 KKPNOBBG_04243 33035.JPJF01000049_gene623 3.4e-173 501.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_04244 1540257.JQMW01000011_gene1682 8.66e-66 204.0 COG1396@1|root,COG1396@2|Bacteria,1VF0W@1239|Firmicutes,24R43@186801|Clostridia,36N1H@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_04245 556261.HMPREF0240_01469 7.22e-246 684.0 COG0438@1|root,COG0438@2|Bacteria,1UBCE@1239|Firmicutes,24DYC@186801|Clostridia 186801|Clostridia M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 KKPNOBBG_04246 33035.JPJF01000049_gene641 0.0 1234.0 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,3XZAR@572511|Blautia 186801|Clostridia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB KKPNOBBG_04247 33035.JPJF01000049_gene642 0.0 910.0 COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia,3XYNQ@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - Na_H_antiporter KKPNOBBG_04248 33035.JPJF01000049_gene643 3.18e-105 306.0 COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia,3Y07M@572511|Blautia 186801|Clostridia K RNA polymerase sigma-70 factor, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_04249 33035.JPJF01000049_gene644 1.89e-140 413.0 2ACB9@1|root,311W7@2|Bacteria,1V49X@1239|Firmicutes,24HTT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - DUF4179 KKPNOBBG_04251 33035.JPJF01000049_gene645 4.45e-231 638.0 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,3XYPX@572511|Blautia 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg KKPNOBBG_04252 33035.JPJF01000049_gene646 2.84e-104 307.0 COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,3XZX7@572511|Blautia 186801|Clostridia O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE KKPNOBBG_04253 33035.JPJF01000049_gene647 0.0 1133.0 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3XZDF@572511|Blautia 186801|Clostridia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 KKPNOBBG_04254 33035.JPJF01000049_gene648 1.03e-235 653.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3XYJ6@572511|Blautia 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG KKPNOBBG_04255 1226325.HMPREF1548_06072 1.92e-37 131.0 COG1846@1|root,COG1846@2|Bacteria,1VE9H@1239|Firmicutes,24P2B@186801|Clostridia,36KQE@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_04256 1232452.BAIB02000016_gene2403 0.0 941.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,268G3@186813|unclassified Clostridiales 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04257 1232452.BAIB02000016_gene2404 1.25e-313 866.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,268EX@186813|unclassified Clostridiales 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04258 33035.JPJF01000049_gene649 5.08e-203 566.0 COG1725@1|root,COG1725@2|Bacteria 2|Bacteria K Transcriptional regulator - - - ko:K07978,ko:K07979 - - - - ko00000,ko03000 - - - GntR KKPNOBBG_04259 33035.JPJF01000049_gene650 3.35e-208 579.0 COG2188@1|root,COG2188@2|Bacteria,1TS1M@1239|Firmicutes,24CNY@186801|Clostridia 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_04260 33035.JPJF01000049_gene651 0.0 1235.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,3XZ8B@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_04261 33035.JPJF01000049_gene652 4.29e-310 847.0 COG0531@1|root,COG0531@2|Bacteria,1V0MG@1239|Firmicutes,25JEH@186801|Clostridia,3Y1KU@572511|Blautia 186801|Clostridia E Amino acid permease - - - - - - - - - - - - AA_permease_2 KKPNOBBG_04262 478749.BRYFOR_07269 5.23e-55 183.0 COG2207@1|root,COG2207@2|Bacteria,1UYG6@1239|Firmicutes 1239|Firmicutes K AraC family transcriptional regulator - - - - - - - - - - - - HTH_18 KKPNOBBG_04263 478749.BRYFOR_07267 7.54e-186 530.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,248X0@186801|Clostridia 186801|Clostridia G solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_04264 478749.BRYFOR_07266 1.75e-138 399.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24B75@186801|Clostridia 186801|Clostridia P Abc transporter, permease protein - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04265 478749.BRYFOR_07265 2.65e-144 412.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04266 649639.Bcell_1103 7.11e-265 752.0 COG3345@1|root,COG3345@2|Bacteria,1TQF4@1239|Firmicutes,4HA5R@91061|Bacilli,1ZBRR@1386|Bacillus 91061|Bacilli G Alpha-galactosidase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase KKPNOBBG_04267 665956.HMPREF1032_00469 4.81e-107 329.0 COG0477@1|root,COG0477@2|Bacteria,1TTC8@1239|Firmicutes,24E7T@186801|Clostridia 186801|Clostridia EGP Major Facilitator Superfamily - - - ko:K08222 - - - - ko00000,ko02000 2.A.1.33 - - MFS_1 KKPNOBBG_04268 33035.JPJF01000049_gene653 4.99e-185 518.0 COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,3XZVM@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K07088 - - - - ko00000 - - - Mem_trans KKPNOBBG_04269 33035.JPJF01000049_gene654 8.48e-215 594.0 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3XZAN@572511|Blautia 186801|Clostridia J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA KKPNOBBG_04270 33035.JPJF01000049_gene655 9.79e-153 431.0 COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3XYGJ@572511|Blautia 186801|Clostridia J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA KKPNOBBG_04271 33035.JPJF01000049_gene656 1.41e-249 688.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,3XYUM@572511|Blautia 186801|Clostridia E Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 KKPNOBBG_04272 33035.JPJF01000049_gene657 7.21e-263 722.0 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,3XZ1T@572511|Blautia 186801|Clostridia H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI KKPNOBBG_04273 33035.JPJF01000049_gene658 3.26e-48 154.0 COG1925@1|root,COG1925@2|Bacteria,1VAQP@1239|Firmicutes,24N19@186801|Clostridia,3Y0BS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - PTS-HPr KKPNOBBG_04274 33035.JPJF01000049_gene659 1e-288 791.0 COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,3XZ0X@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 KKPNOBBG_04275 33035.JPJF01000049_gene660 6.53e-58 179.0 COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia,3Y0G3@572511|Blautia 186801|Clostridia S Belongs to the UPF0297 family yrzL - - - - - - - - - - - DUF965 KKPNOBBG_04276 33035.JPJF01000049_gene661 4.09e-96 280.0 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,3Y00X@572511|Blautia 186801|Clostridia L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX KKPNOBBG_04277 33035.JPJF01000049_gene662 3.24e-42 140.0 2E3Y4@1|root,32YV4@2|Bacteria,1VFRH@1239|Firmicutes,24QXW@186801|Clostridia,3Y0M4@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF1292 KKPNOBBG_04278 33035.JPJF01000049_gene663 0.0 1069.0 COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3XZS3@572511|Blautia 186801|Clostridia S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL KKPNOBBG_04279 33035.JPJF01000049_gene664 1.27e-72 218.0 COG3679@1|root,COG3679@2|Bacteria,1VH19@1239|Firmicutes,24RNC@186801|Clostridia,3Y0MG@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Com_YlbF KKPNOBBG_04280 33035.JPJF01000049_gene665 3.29e-93 275.0 COG1559@1|root,COG1559@2|Bacteria,1VGA6@1239|Firmicutes,24RBR@186801|Clostridia,3Y0GT@572511|Blautia 186801|Clostridia S YceG-like family - - - ko:K07082 - - - - ko00000 - - - YceG KKPNOBBG_04281 33035.JPJF01000049_gene666 6.55e-135 384.0 COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,3XYN3@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yrrM - - - - - - - - - - - Methyltransf_3 KKPNOBBG_04282 33035.JPJF01000049_gene667 3.2e-307 836.0 COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,3XYM5@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 yhbU_1 - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C KKPNOBBG_04283 33035.JPJF01000049_gene668 5.75e-132 375.0 COG1191@1|root,COG1191@2|Bacteria,1TPJ5@1239|Firmicutes,247XH@186801|Clostridia,3XYT5@572511|Blautia 186801|Clostridia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released sigK - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 KKPNOBBG_04284 33035.JPJF01000049_gene669 1.15e-42 140.0 2DQDV@1|root,33675@2|Bacteria,1VITX@1239|Firmicutes,24S3U@186801|Clostridia 186801|Clostridia K Helix-turn-helix - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_04285 33035.JPJF01000049_gene670 9.32e-139 399.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_04286 33035.JPJF01000049_gene671 0.0 918.0 COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,3XYVC@572511|Blautia 186801|Clostridia O magnesium chelatase, subunit ChlI comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C KKPNOBBG_04287 33035.JPJF01000049_gene672 6.23e-190 530.0 COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,3XYUB@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A KKPNOBBG_04288 33035.JPJF01000049_gene673 0.0 1360.0 COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3XZ2U@572511|Blautia 186801|Clostridia L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,zf-C4_Topoisom KKPNOBBG_04289 33035.JPJF01000094_gene2143 3.37e-178 497.0 COG4465@1|root,COG4465@2|Bacteria,1TS7A@1239|Firmicutes,2480R@186801|Clostridia,3XYZ9@572511|Blautia 186801|Clostridia K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor codY - - ko:K03706 - - - - ko00000,ko03000 - - - CodY,HTH_CodY KKPNOBBG_04290 33035.JPJF01000094_gene2142 1.02e-56 176.0 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,3Y05R@572511|Blautia 186801|Clostridia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 KKPNOBBG_04291 33035.JPJF01000094_gene2141 0.0 983.0 COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3XYV2@572511|Blautia 186801|Clostridia O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 KKPNOBBG_04292 33035.JPJF01000094_gene2140 4e-100 292.0 2E823@1|root,332G5@2|Bacteria,1V8A8@1239|Firmicutes,24NHT@186801|Clostridia,3Y088@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.75 - - - - - - - - - - - - - KKPNOBBG_04293 33035.JPJF01000094_gene2139 0.0 924.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,3XZR0@572511|Blautia 186801|Clostridia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO KKPNOBBG_04294 33035.JPJF01000094_gene2138 1.97e-149 422.0 COG5632@1|root,COG5632@2|Bacteria,1V3JT@1239|Firmicutes,24D7K@186801|Clostridia,3XZWS@572511|Blautia 186801|Clostridia M Psort location Cytoplasmic, score 8.87 - - 3.5.1.28 ko:K01447 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Amidase_2 KKPNOBBG_04295 33035.JPJF01000094_gene2137 1.24e-280 778.0 COG2972@1|root,COG2972@2|Bacteria,1VS09@1239|Firmicutes,24AV3@186801|Clostridia,3Y1HV@572511|Blautia 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04296 33035.JPJF01000024_gene3138 4.42e-165 462.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UUUY@1239|Firmicutes,25KCT@186801|Clostridia,3Y1GV@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_04297 33035.JPJF01000024_gene3139 0.0 887.0 COG1653@1|root,COG1653@2|Bacteria,1TRAX@1239|Firmicutes,2497E@186801|Clostridia,3Y0JS@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_04298 33035.JPJF01000024_gene3140 4.02e-202 560.0 COG1175@1|root,COG1175@2|Bacteria,1UZE5@1239|Firmicutes,25MIN@186801|Clostridia,3Y15U@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04299 33035.JPJF01000024_gene3141 2.6e-197 547.0 COG0395@1|root,COG0395@2|Bacteria,1TSM1@1239|Firmicutes,25C4V@186801|Clostridia,3Y1GS@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04300 33035.JPJF01000024_gene3142 0.0 1399.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia,3Y2CQ@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 31 - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31 KKPNOBBG_04301 33035.JPJF01000024_gene3143 0.0 1383.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,248WR@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF5110,Glyco_hydro_31 KKPNOBBG_04302 33035.JPJF01000024_gene3144 5.1e-103 301.0 COG5578@1|root,COG5578@2|Bacteria,1VI97@1239|Firmicutes,24TB6@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 KKPNOBBG_04303 33035.JPJF01000024_gene3145 0.0 1513.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3Y0MS@572511|Blautia 186801|Clostridia G COG COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 KKPNOBBG_04304 33035.JPJF01000024_gene3146 6.22e-58 180.0 COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24J8R@186801|Clostridia,3Y0P1@572511|Blautia 186801|Clostridia S Putative heavy-metal-binding - - - - - - - - - - - - YbjQ_1 KKPNOBBG_04305 537007.BLAHAN_06334 2.14e-60 199.0 2B3F4@1|root,31W41@2|Bacteria,1TTZ3@1239|Firmicutes,25ABE@186801|Clostridia,3Y0T7@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - - KKPNOBBG_04306 33035.JPJF01000024_gene3148 2.13e-161 452.0 COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,249FR@186801|Clostridia,3XYHK@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_04307 33035.JPJF01000024_gene3149 3.61e-75 225.0 COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia,3Y05T@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - GntR KKPNOBBG_04308 33035.JPJF01000024_gene3150 2.19e-170 476.0 COG0778@1|root,COG0778@2|Bacteria,1V0I6@1239|Firmicutes,24ASS@186801|Clostridia 186801|Clostridia C Putative TM nitroreductase - - - - - - - - - - - - TM1586_NiRdase KKPNOBBG_04309 33035.JPJF01000024_gene3151 2.42e-202 566.0 COG0463@1|root,COG0463@2|Bacteria,1TQEM@1239|Firmicutes,249HH@186801|Clostridia,3XZ06@572511|Blautia 186801|Clostridia M Glycosyl transferase family 2 sunS - - - - - - - - - - - Glycos_transf_2,TPR_8 KKPNOBBG_04310 457421.CBFG_01181 1.57e-11 73.9 COG2931@1|root,COG2931@2|Bacteria,1TSGB@1239|Firmicutes,247TS@186801|Clostridia 186801|Clostridia Q PFAM Collagen triple helix - - - - - - - - - - - - Collagen KKPNOBBG_04312 411467.BACCAP_02705 0.000147 43.5 COG3655@1|root,COG3655@2|Bacteria,1VEM0@1239|Firmicutes,24QPN@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_26 KKPNOBBG_04313 1211844.CBLM010000001_gene618 5.61e-137 416.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,3VPYN@526524|Erysipelotrichia 526524|Erysipelotrichia L Recombinase zinc beta ribbon domain - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_04314 411470.RUMGNA_01130 5.6e-12 63.2 2CC5T@1|root,31XII@2|Bacteria,1UDPT@1239|Firmicutes,25IGS@186801|Clostridia,3Y1SJ@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04315 742741.HMPREF9475_02626 3.21e-61 191.0 2DTHZ@1|root,32UVA@2|Bacteria,1W1A3@1239|Firmicutes,24RA5@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04316 1121115.AXVN01000094_gene755 4.38e-127 385.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,3XZGT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 abgB - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 KKPNOBBG_04317 33035.JPJF01000024_gene3153 0.0 885.0 COG1680@1|root,COG3439@1|root,COG1680@2|Bacteria,COG3439@2|Bacteria,1V0GX@1239|Firmicutes,24BIH@186801|Clostridia 186801|Clostridia V Domain of unknown function DUF302 - - - - - - - - - - - - Beta-lactamase,DUF302 KKPNOBBG_04319 33035.JPJF01000009_gene1481 1.27e-45 172.0 COG3069@1|root,COG3069@2|Bacteria,1U0AJ@1239|Firmicutes,24DKS@186801|Clostridia 186801|Clostridia C C4-dicarboxylate anaerobic carrier - - - ko:K03326 - - - - ko00000,ko02000 2.A.61.1 - - DcuC KKPNOBBG_04320 1005994.GTGU_02761 2.07e-31 133.0 COG3069@1|root,COG3069@2|Bacteria,1MWBG@1224|Proteobacteria,1RQB2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C C4-dicarboxylate - - - ko:K03326 - - - - ko00000,ko02000 2.A.61.1 - - DcuC KKPNOBBG_04321 556261.HMPREF0240_00555 1.53e-06 57.8 COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04322 1123075.AUDP01000016_gene3428 2.97e-54 187.0 COG0407@1|root,COG0407@2|Bacteria,1TNZU@1239|Firmicutes,24A05@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04323 536227.CcarbDRAFT_4590 4.31e-59 198.0 COG0583@1|root,COG0583@2|Bacteria,1UZ63@1239|Firmicutes,25C72@186801|Clostridia,36WQQ@31979|Clostridiaceae 186801|Clostridia K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04324 33035.JPJF01000024_gene3154 1.69e-72 218.0 COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia,3Y0M6@572511|Blautia 186801|Clostridia S Cyclic-di-AMP receptor yaaQ - - - - - - - - - - - CdAMP_rec KKPNOBBG_04325 33035.JPJF01000024_gene3155 1.54e-146 414.0 COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia 186801|Clostridia S Na channel or pump - - - ko:K07150 - - - - ko00000 - - - DUF554 KKPNOBBG_04326 33035.JPJF01000024_gene3156 1.12e-77 231.0 COG0662@1|root,COG0662@2|Bacteria,1UI0P@1239|Firmicutes,24SCP@186801|Clostridia 186801|Clostridia G Cupin domain - - - - - - - - - - - - Cupin_2 KKPNOBBG_04327 33035.JPJF01000024_gene3157 3.16e-62 194.0 COG0437@1|root,COG0437@2|Bacteria,1V9CW@1239|Firmicutes,24KKH@186801|Clostridia,3Y073@572511|Blautia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_4 KKPNOBBG_04328 33035.JPJF01000024_gene3158 5.74e-211 583.0 COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,3XYMJ@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_4 KKPNOBBG_04329 33035.JPJF01000024_gene3159 5.3e-286 783.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,3XZFU@572511|Blautia 186801|Clostridia S ABC transporter substrate-binding protein PnrA-like - - - ko:K07335 - - - - ko00000 - - - Bmp KKPNOBBG_04330 33035.JPJF01000024_gene3160 0.0 984.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,3XYKD@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran KKPNOBBG_04331 33035.JPJF01000024_gene3161 7.35e-250 687.0 COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3XZ08@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 tsgB13 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 KKPNOBBG_04332 33035.JPJF01000024_gene3162 4.06e-218 603.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3XZAK@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 tsgC13 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 KKPNOBBG_04333 33035.JPJF01000024_gene3163 4.78e-204 568.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3XYW0@572511|Blautia 186801|Clostridia H Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 KKPNOBBG_04334 33035.JPJF01000024_gene3164 5.36e-106 307.0 COG5652@1|root,COG5652@2|Bacteria,1V72A@1239|Firmicutes,259NP@186801|Clostridia,3Y02J@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - VanZ KKPNOBBG_04335 33035.JPJF01000024_gene3165 1.05e-279 771.0 COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,3XYZK@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF KKPNOBBG_04336 33035.JPJF01000024_gene3166 5.74e-205 566.0 COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,249QG@186801|Clostridia,3XYU4@572511|Blautia 186801|Clostridia H Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt KKPNOBBG_04337 33035.JPJF01000024_gene3167 3.94e-107 310.0 COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,24FTH@186801|Clostridia,3XZXR@572511|Blautia 186801|Clostridia H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 KKPNOBBG_04338 33035.JPJF01000024_gene3168 1.1e-246 677.0 COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,3XZFI@572511|Blautia 186801|Clostridia EH Psort location Cytoplasmic, score 8.87 ilvE - 2.6.1.42,4.1.3.38 ko:K00826,ko:K02619 ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R05553,R10991 RC00006,RC00036,RC01843,RC02148 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 KKPNOBBG_04339 33035.JPJF01000024_gene3169 5.83e-268 739.0 COG4915@1|root,COG4915@2|Bacteria,1U2SU@1239|Firmicutes,24B5W@186801|Clostridia,3XZ35@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Halogen_Hydrol KKPNOBBG_04340 33035.JPJF01000024_gene3170 1.47e-249 687.0 COG3853@1|root,COG3853@2|Bacteria,1TQVX@1239|Firmicutes,24A2H@186801|Clostridia,3XYPJ@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TelA KKPNOBBG_04341 33035.JPJF01000024_gene3171 3.43e-238 656.0 COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,3XYGT@572511|Blautia 186801|Clostridia H Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06430 GcpE KKPNOBBG_04342 33035.JPJF01000024_gene3172 0.0 2858.0 COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,3XZ9M@572511|Blautia 186801|Clostridia L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity polC - 2.7.7.7 ko:K03763 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon KKPNOBBG_04344 33035.JPJF01000024_gene3174 1.99e-282 775.0 COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3XYMS@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M KKPNOBBG_04345 33035.JPJF01000024_gene3175 1.49e-126 360.0 COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,3XZBC@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI KKPNOBBG_04346 1123075.AUDP01000003_gene479 7.16e-60 191.0 COG1418@1|root,COG1418@2|Bacteria,1VBWP@1239|Firmicutes,24JJV@186801|Clostridia,3WJVP@541000|Ruminococcaceae 186801|Clostridia S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD KKPNOBBG_04347 33035.JPJF01000024_gene3177 8.61e-183 509.0 COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,3XYIG@572511|Blautia 186801|Clostridia H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS03115 Pterin_bind KKPNOBBG_04348 33035.JPJF01000024_gene3178 5.81e-183 510.0 COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,3XZG7@572511|Blautia 186801|Clostridia H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folK - 2.7.6.3,4.1.2.25 ko:K00950,ko:K13940 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503,R03504 RC00002,RC00017,RC00721,RC00943 ko00000,ko00001,ko00002,ko01000 - - - FolB,HPPK KKPNOBBG_04349 33035.JPJF01000024_gene3179 4.69e-261 715.0 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,3XYRN@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 hisC - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 KKPNOBBG_04350 33035.JPJF01000024_gene3180 0.0 2191.0 2C1EE@1|root,2Z86R@2|Bacteria,1TS39@1239|Firmicutes,24ABS@186801|Clostridia,3XZIB@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 Rnd - - - - - - - - - - - - KKPNOBBG_04351 33035.JPJF01000024_gene3181 3.48e-309 841.0 28MVQ@1|root,2ZB38@2|Bacteria,1UUTH@1239|Firmicutes,24AV8@186801|Clostridia,3XZBP@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04352 33035.JPJF01000024_gene3182 3.52e-178 497.0 2B4WY@1|root,31XPQ@2|Bacteria,1V739@1239|Firmicutes,24D1P@186801|Clostridia,3Y01X@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TPR_8 KKPNOBBG_04353 33035.JPJF01000024_gene3183 3.82e-166 464.0 COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,3XZ17@572511|Blautia 186801|Clostridia F Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase purC - 4.3.2.2,6.3.2.6 ko:K01756,ko:K01923 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559,R04591 RC00064,RC00162,RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt KKPNOBBG_04354 33035.JPJF01000024_gene3184 0.0 920.0 COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,3XZ1Q@572511|Blautia 186801|Clostridia F Psort location Cytoplasmic, score 8.87 purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 KKPNOBBG_04355 33035.JPJF01000024_gene3185 8.43e-283 776.0 COG1757@1|root,COG1757@2|Bacteria,1TQPI@1239|Firmicutes,2495U@186801|Clostridia,3XZ6V@572511|Blautia 186801|Clostridia C Psort location CytoplasmicMembrane, score 10.00 mleN_2 - - - - - - - - - - - Na_H_antiporter KKPNOBBG_04356 1158610.UC3_00386 1.35e-22 102.0 COG2207@1|root,COG2207@2|Bacteria,1V2EN@1239|Firmicutes,4HG9I@91061|Bacilli,4B0Z0@81852|Enterococcaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_04357 180332.JTGN01000018_gene75 3.82e-193 551.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24C14@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04358 1123075.AUDP01000005_gene914 3.61e-140 409.0 COG5012@1|root,COG5012@2|Bacteria 2|Bacteria T cobalamin binding - - - - - - - - - - - - - KKPNOBBG_04359 33035.JPJF01000024_gene3187 1.21e-93 275.0 COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia,3Y0EM@572511|Blautia 186801|Clostridia K COG COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_04360 33035.JPJF01000024_gene3188 1.49e-271 751.0 28NHG@1|root,2ZBJ9@2|Bacteria,1V1QG@1239|Firmicutes,24GQ1@186801|Clostridia,3Y0RS@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF4179) - - - - - - - - - - - - DUF4179 KKPNOBBG_04361 33035.JPJF01000024_gene3189 1.95e-316 861.0 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3XYKX@572511|Blautia 186801|Clostridia F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt KKPNOBBG_04362 33035.JPJF01000024_gene3190 3.38e-187 521.0 COG1011@1|root,COG1011@2|Bacteria,1V6I4@1239|Firmicutes,24JK7@186801|Clostridia,3XZZB@572511|Blautia 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase KKPNOBBG_04363 33035.JPJF01000024_gene3191 2.09e-203 565.0 COG2866@1|root,COG2866@2|Bacteria,1TP3K@1239|Firmicutes,249MT@186801|Clostridia,3Y00J@572511|Blautia 186801|Clostridia E Zn_pept - - 3.4.19.11 ko:K01308 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M14 KKPNOBBG_04364 33035.JPJF01000024_gene3194 9.92e-188 525.0 COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,3XZ9Y@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04365 742740.HMPREF9474_00703 1.9e-187 541.0 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,24A4G@186801|Clostridia 186801|Clostridia E Aromatic amino acid lyase - - - - - - - - - - - - Lyase_aromatic KKPNOBBG_04366 33035.JPJF01000024_gene3195 0.0 989.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia 186801|Clostridia M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K05020 - - - - ko00000,ko02000 2.A.15.1.1,2.A.15.1.11 - - BCCT KKPNOBBG_04367 33035.JPJF01000024_gene3196 3.16e-226 624.0 COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,24DP8@186801|Clostridia,3Y1YQ@572511|Blautia 186801|Clostridia E Ornithine cyclodeaminase/mu-crystallin family - - 4.3.1.12 ko:K01750 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall KKPNOBBG_04368 33035.JPJF01000024_gene3197 6.85e-55 171.0 COG1254@1|root,COG1254@2|Bacteria,1VEM9@1239|Firmicutes,24QXB@186801|Clostridia,3Y0J7@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase KKPNOBBG_04369 658086.HMPREF0994_05990 2.8e-70 212.0 COG1917@1|root,COG1917@2|Bacteria,1VGJQ@1239|Firmicutes,25EGC@186801|Clostridia,27NAY@186928|unclassified Lachnospiraceae 186801|Clostridia S Cupin domain - - - - - - - - - - - - Cupin_2 KKPNOBBG_04370 33035.JPJF01000024_gene3199 1.9e-211 587.0 COG2207@1|root,COG2207@2|Bacteria,1V4S9@1239|Firmicutes,25KCU@186801|Clostridia,3Y1XZ@572511|Blautia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_04371 33035.JPJF01000024_gene3200 1.95e-251 695.0 COG0524@1|root,COG0524@2|Bacteria,1TT7Y@1239|Firmicutes,249GN@186801|Clostridia,3Y120@572511|Blautia 186801|Clostridia G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB KKPNOBBG_04372 33035.JPJF01000024_gene3201 1.73e-166 469.0 COG0191@1|root,COG0191@2|Bacteria,1TRS4@1239|Firmicutes,24CD4@186801|Clostridia,3Y15G@572511|Blautia 186801|Clostridia G COG COG0191 Fructose tagatose bisphosphate aldolase - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase KKPNOBBG_04373 33035.JPJF01000024_gene3206 2.48e-86 255.0 arCOG06631@1|root,32RY6@2|Bacteria,1V8RP@1239|Firmicutes,24MV5@186801|Clostridia 186801|Clostridia S PFAM EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_04374 33035.JPJF01000024_gene3207 9.18e-243 667.0 COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,24BUV@186801|Clostridia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04375 33035.JPJF01000024_gene3208 4.14e-230 632.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,24ECM@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_04376 33035.JPJF01000024_gene3209 5.55e-223 614.0 COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia 186801|Clostridia G TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N KKPNOBBG_04377 33035.JPJF01000024_gene3210 0.0 876.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 gph - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_04378 33035.JPJF01000024_gene3211 9.02e-232 640.0 COG1609@1|root,COG1609@2|Bacteria,1VT4I@1239|Firmicutes,24YJ2@186801|Clostridia 186801|Clostridia K Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_4 KKPNOBBG_04379 457412.RSAG_01534 4.93e-198 562.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,3WJP9@541000|Ruminococcaceae 186801|Clostridia G Extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04380 457412.RSAG_01533 2.14e-170 480.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3WJ61@541000|Ruminococcaceae 186801|Clostridia P transport systems - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04381 457412.RSAG_01532 1.95e-157 446.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3WIS9@541000|Ruminococcaceae 186801|Clostridia P ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04382 457412.RSAG_01531 3.11e-104 311.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V27N@1239|Firmicutes,24EUU@186801|Clostridia,3WPI2@541000|Ruminococcaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04383 457412.RSAG_01530 1.81e-166 494.0 COG2972@1|root,COG2972@2|Bacteria,1V4G9@1239|Firmicutes,24IA9@186801|Clostridia,3WP6J@541000|Ruminococcaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase KKPNOBBG_04384 457412.RSAG_01529 0.0 1061.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3WH8U@541000|Ruminococcaceae 186801|Clostridia G beta-galactosidase - - - - - - - - - - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_04385 180332.JTGN01000004_gene2528 3.1e-59 233.0 COG1409@1|root,COG1554@1|root,COG1409@2|Bacteria,COG1554@2|Bacteria,1UYQF@1239|Firmicutes,24AYB@186801|Clostridia 186801|Clostridia G Glycosyl hydrolase family 65, N-terminal domain - - - - - - - - - - - - Glyco_hyd_65N_2 KKPNOBBG_04386 180332.JTGN01000015_gene1118 3.88e-29 119.0 2DWV7@1|root,3421J@2|Bacteria,1VX8N@1239|Firmicutes,251PW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04387 33035.JPJF01000024_gene3218 0.0 1326.0 COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,3Y0TP@572511|Blautia 186801|Clostridia G Alpha-L-rhamnosidase N-terminal domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N KKPNOBBG_04388 33035.JPJF01000024_gene3219 3.84e-191 533.0 COG2207@1|root,COG2207@2|Bacteria,1UI0R@1239|Firmicutes,25E9C@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_04389 33035.JPJF01000008_gene1144 5.65e-199 555.0 COG4586@1|root,COG4586@2|Bacteria,1UHZR@1239|Firmicutes,25E8F@186801|Clostridia 186801|Clostridia S ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_04390 33035.JPJF01000008_gene1145 1.77e-153 435.0 COG4587@1|root,COG4587@2|Bacteria,1UZTC@1239|Firmicutes,24E7Q@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 KKPNOBBG_04391 33035.JPJF01000008_gene1146 7.75e-145 412.0 COG3694@1|root,COG3694@2|Bacteria,1V0CD@1239|Firmicutes,248XM@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_6 KKPNOBBG_04392 33035.JPJF01000008_gene1147 2.39e-145 412.0 COG2043@1|root,COG2043@2|Bacteria,1UYUH@1239|Firmicutes,24APQ@186801|Clostridia 186801|Clostridia S PFAM Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 KKPNOBBG_04393 33035.JPJF01000008_gene1150 4.32e-292 798.0 COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04394 33035.JPJF01000008_gene1151 4.34e-212 587.0 COG2207@1|root,COG2207@2|Bacteria,1V0IW@1239|Firmicutes,24BME@186801|Clostridia,3Y09S@572511|Blautia 2|Bacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_04395 397287.C807_01993 5.18e-118 359.0 COG1653@1|root,COG1653@2|Bacteria,1TQJE@1239|Firmicutes,2496C@186801|Clostridia,27TXF@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04396 1120746.CCNL01000017_gene3099 8.45e-267 768.0 COG3459@1|root,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding - - - - - - - - - - - - Glyco_hydro_36 KKPNOBBG_04397 1499684.CCNP01000017_gene508 9.38e-147 431.0 COG1653@1|root,COG1653@2|Bacteria,1TPBF@1239|Firmicutes,24920@186801|Clostridia,36FKU@31979|Clostridiaceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04398 397288.C806_00623 4.02e-123 361.0 COG1175@1|root,COG1175@2|Bacteria,1TVDI@1239|Firmicutes,24B2S@186801|Clostridia,27KT6@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04399 1499684.CCNP01000017_gene510 1.64e-138 399.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,36E7H@31979|Clostridiaceae 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K10202 ko02010,map02010 M00205 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.18 - - BPD_transp_1 KKPNOBBG_04400 397287.C807_01989 3.84e-67 230.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UNEQ@1239|Firmicutes,24E34@186801|Clostridia,27PC0@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04401 180332.JTGN01000003_gene2169 5.74e-77 263.0 COG2972@1|root,COG2972@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_04403 500632.CLONEX_02958 1.26e-98 357.0 COG1196@1|root,COG5434@1|root,COG1196@2|Bacteria,COG5434@2|Bacteria,1TRWY@1239|Firmicutes,24DY3@186801|Clostridia 186801|Clostridia M Parallel beta-helix repeats - - - - - - - - - - - - FIVAR,fn3 KKPNOBBG_04404 1298920.KI911353_gene2848 4.01e-91 277.0 COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,24EN4@186801|Clostridia,21ZA7@1506553|Lachnoclostridium 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04405 1304866.K413DRAFT_4132 6.41e-42 145.0 COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia,36WPU@31979|Clostridiaceae 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04406 357809.Cphy_3031 1.25e-164 464.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,25C5F@186801|Clostridia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04407 357809.Cphy_3029 1.8e-221 617.0 COG4225@1|root,COG4225@2|Bacteria,1TR4A@1239|Firmicutes,24YXA@186801|Clostridia,21YKI@1506553|Lachnoclostridium 186801|Clostridia S Glycosyl Hydrolase Family 88 - - 3.2.1.180 ko:K18581 - - R10867 RC00049,RC02427 ko00000,ko01000 - GH88 - Glyco_hydro_88 KKPNOBBG_04408 357809.Cphy_3028 8.5e-238 665.0 COG3669@1|root,COG3669@2|Bacteria,1TSG7@1239|Firmicutes,247VJ@186801|Clostridia,21Y31@1506553|Lachnoclostridium 186801|Clostridia G SMART glycoside hydrolase family 29 (alpha-L-fucosidase) - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Calx-beta,F5_F8_type_C,FIVAR,Gram_pos_anchor KKPNOBBG_04409 1298920.KI911353_gene2843 1.24e-238 667.0 COG1653@1|root,COG1653@2|Bacteria,1TQ6X@1239|Firmicutes,24DW8@186801|Clostridia,21ZDJ@1506553|Lachnoclostridium 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1 KKPNOBBG_04410 357809.Cphy_3024 1.1e-172 489.0 COG0613@1|root,COG0613@2|Bacteria,1V6HN@1239|Firmicutes,24DQ6@186801|Clostridia,21Z35@1506553|Lachnoclostridium 186801|Clostridia S DNA polymerase alpha chain like domain - - - - - - - - - - - - - KKPNOBBG_04411 180332.JTGN01000001_gene4780 2.19e-216 607.0 COG3669@1|root,COG3669@2|Bacteria,1TQH2@1239|Firmicutes,24B8Y@186801|Clostridia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,CBM_6,F5_F8_type_C KKPNOBBG_04412 537007.BLAHAN_05982 0.0 949.0 COG1554@1|root,COG1554@2|Bacteria,1TPKN@1239|Firmicutes,248K8@186801|Clostridia,3XZ09@572511|Blautia 186801|Clostridia G COG NOG04001 non supervised orthologous group - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 KKPNOBBG_04413 357809.Cphy_3034 1.26e-221 630.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1VSTB@1239|Firmicutes,24DIW@186801|Clostridia,21ZR8@1506553|Lachnoclostridium 186801|Clostridia K helix-turn-helix- domain containing protein AraC type - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_04414 357809.Cphy_3033 1.17e-254 721.0 COG2972@1|root,COG2972@2|Bacteria,1VR0E@1239|Firmicutes,24CW7@186801|Clostridia,21Z3P@1506553|Lachnoclostridium 186801|Clostridia T histidine kinase HAMP region domain protein - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04415 97139.C824_03757 1.36e-264 727.0 COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24DSM@186801|Clostridia,36M2M@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04416 97139.C824_03758 6.03e-197 548.0 COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia,36G1X@31979|Clostridiaceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N KKPNOBBG_04417 97139.C824_03759 1.27e-181 506.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia,36GBX@31979|Clostridiaceae 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) - - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_04418 97139.C824_03760 3.57e-214 600.0 COG1879@1|root,COG1879@2|Bacteria,1TSN1@1239|Firmicutes,249RI@186801|Clostridia 186801|Clostridia G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 KKPNOBBG_04419 97139.C824_03761 1.11e-306 842.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae 186801|Clostridia P import. Responsible for energy coupling to the transport system - - 3.6.3.17 ko:K02056,ko:K17204 ko02010,map02010 M00221,M00590 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.11,3.A.1.2.16 - - ABC_tran KKPNOBBG_04420 97139.C824_03762 5.9e-196 547.0 COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae 186801|Clostridia G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 KKPNOBBG_04421 97139.C824_03763 1.87e-269 739.0 COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24DSM@186801|Clostridia,36M2M@31979|Clostridiaceae 186801|Clostridia S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04422 97139.C824_03764 0.0 1094.0 COG1609@1|root,COG1879@1|root,COG1609@2|Bacteria,COG1879@2|Bacteria,1TQ7K@1239|Firmicutes,248BZ@186801|Clostridia,36E93@31979|Clostridiaceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3,Peripla_BP_4 KKPNOBBG_04423 908340.HMPREF9406_1644 6.42e-70 221.0 2F36Y@1|root,33W1E@2|Bacteria,1VVRN@1239|Firmicutes,251F2@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04424 1280689.AUJC01000003_gene1016 1.02e-40 139.0 COG1846@1|root,COG1846@2|Bacteria,1VDY5@1239|Firmicutes,24Q37@186801|Clostridia,36M8F@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR KKPNOBBG_04425 658086.HMPREF0994_03693 2.1e-121 355.0 COG0702@1|root,COG0702@2|Bacteria,1UY7W@1239|Firmicutes,24CSQ@186801|Clostridia 186801|Clostridia GM NmrA-like family - - - - - - - - - - - - NmrA KKPNOBBG_04426 397291.C804_02733 3.46e-126 364.0 COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,27M8R@186928|unclassified Lachnospiraceae 186801|Clostridia K DeoR C terminal sensor domain - - - ko:K03436 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR KKPNOBBG_04427 1340493.JNIF01000003_gene3465 5.5e-165 481.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - DUF4976,Sulfatase KKPNOBBG_04428 180332.JTGN01000020_gene1187 9.36e-115 330.0 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes 1239|Firmicutes GK acetyltransferase, isoleucine patch superfamily - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2,Mac KKPNOBBG_04429 658086.HMPREF0994_03634 4.73e-213 600.0 COG1653@1|root,COG1653@2|Bacteria,1UV0J@1239|Firmicutes,24H7P@186801|Clostridia,27PP3@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_04430 658086.HMPREF0994_03633 3.13e-202 562.0 COG1175@1|root,COG1175@2|Bacteria,1TPTZ@1239|Firmicutes,24EC2@186801|Clostridia,27TIF@186928|unclassified Lachnospiraceae 186801|Clostridia U Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04431 658086.HMPREF0994_03632 5.96e-178 498.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,249NY@186801|Clostridia,27M5M@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04432 397291.C804_02737 1.02e-67 214.0 COG0796@1|root,COG0796@2|Bacteria,1UING@1239|Firmicutes 1239|Firmicutes M Provides the (R)-glutamate required for cell wall biosynthesis - - - - - - - - - - - - Asp_Glu_race KKPNOBBG_04433 397291.C804_02738 7.12e-174 504.0 COG1070@1|root,COG1070@2|Bacteria,1VU7X@1239|Firmicutes,24YYG@186801|Clostridia,27S1M@186928|unclassified Lachnospiraceae 186801|Clostridia G FGGY family of carbohydrate kinases, N-terminal domain - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_04434 180332.JTGN01000006_gene3449 2.78e-145 417.0 COG0191@1|root,COG0191@2|Bacteria,1UYHC@1239|Firmicutes,24C26@186801|Clostridia 186801|Clostridia G Fructose-bisphosphate aldolase class-II - - - - - - - - - - - - F_bP_aldolase KKPNOBBG_04435 397291.C804_02740 0.0 1338.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,24DH1@186801|Clostridia,27RGM@186928|unclassified Lachnospiraceae 186801|Clostridia G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_04436 397291.C804_02741 5.52e-169 488.0 COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,27Q19@186928|unclassified Lachnospiraceae 186801|Clostridia S Putative nucleotide-binding of sugar-metabolising enzyme - - 2.7.1.219,2.7.1.220 ko:K22129 - - - - ko00000,ko01000 - - - DUF1357_C,DUF1537 KKPNOBBG_04437 180332.JTGN01000006_gene3446 3.73e-104 306.0 COG0279@1|root,COG0279@2|Bacteria,1V5W5@1239|Firmicutes,24INX@186801|Clostridia 186801|Clostridia G isomerase gmhA - 5.3.1.28 ko:K03271 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005 - - - SIS_2 KKPNOBBG_04438 658086.HMPREF0994_03629 7.62e-158 451.0 COG1940@1|root,COG1940@2|Bacteria,1TRGJ@1239|Firmicutes,248TJ@186801|Clostridia,27RH2@186928|unclassified Lachnospiraceae 186801|Clostridia GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK KKPNOBBG_04439 658086.HMPREF0994_03628 0.0 1542.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,27KWU@186928|unclassified Lachnospiraceae 186801|Clostridia G Alpha mannosidase, middle domain - - - - - - - - - - - - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_04440 180332.JTGN01000006_gene3442 0.0 1045.0 COG3250@1|root,COG3250@2|Bacteria 2|Bacteria G beta-galactosidase activity - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C KKPNOBBG_04441 658086.HMPREF0994_07243 0.0 1059.0 COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,27J0U@186928|unclassified Lachnospiraceae 186801|Clostridia C Pyruvate formate lyase-like - - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - - Gly_radical,PFL-like KKPNOBBG_04442 658086.HMPREF0994_03624 1.59e-97 296.0 COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia 186801|Clostridia C glycyl-radical enzyme activating protein family - - - - - - - - - - - - Fer4_12,Radical_SAM KKPNOBBG_04443 397291.C804_02745 1.67e-281 794.0 COG3345@1|root,COG3345@2|Bacteria,1UCW9@1239|Firmicutes,24C3B@186801|Clostridia,27JBG@186928|unclassified Lachnospiraceae 186801|Clostridia G Raffinose synthase or seed imbibition protein Sip1 - - - - - - - - - - - - Raffinose_syn KKPNOBBG_04444 397291.C804_02746 1.41e-83 253.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,27TM4@186928|unclassified Lachnospiraceae 186801|Clostridia G Class II Aldolase and Adducin N-terminal domain - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II KKPNOBBG_04445 658086.HMPREF0994_03622 0.0 1033.0 COG3345@1|root,COG3345@2|Bacteria,1TSZB@1239|Firmicutes,247VV@186801|Clostridia,27KI1@186928|unclassified Lachnospiraceae 186801|Clostridia G Melibiase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase KKPNOBBG_04446 658086.HMPREF0994_03621 1.98e-232 653.0 COG3119@1|root,COG3119@2|Bacteria,1TQEP@1239|Firmicutes,2482B@186801|Clostridia 186801|Clostridia P Psort location Cytoplasmic, score - - - - - - - - - - - - DUF4976,Sulfatase KKPNOBBG_04447 658086.HMPREF0994_01250 6.06e-11 63.9 COG0366@1|root,COG0366@2|Bacteria,1TR93@1239|Firmicutes,24AB0@186801|Clostridia,27K8B@186928|unclassified Lachnospiraceae 186801|Clostridia G Sucrose phosphorylase - GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758 2.4.1.329 ko:K21350 - - - - ko00000,ko01000 - GH13 - Alpha-amylase KKPNOBBG_04449 33035.JPJF01000072_gene4349 4.5e-160 449.0 COG0204@1|root,COG0204@2|Bacteria,1TTPK@1239|Firmicutes,24B6K@186801|Clostridia,3XYHT@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase KKPNOBBG_04450 33035.JPJF01000072_gene4350 4.17e-112 324.0 2BWC2@1|root,33RSK@2|Bacteria,1VS2M@1239|Firmicutes,24YI2@186801|Clostridia,3Y093@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04451 33035.JPJF01000072_gene4351 0.0 1588.0 COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,3XZN8@572511|Blautia 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV KKPNOBBG_04452 33035.JPJF01000072_gene4352 0.0 1241.0 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,3XYYE@572511|Blautia 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim KKPNOBBG_04453 33035.JPJF01000072_gene4353 7.39e-253 694.0 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,3XZEV@572511|Blautia 186801|Clostridia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N KKPNOBBG_04454 33035.JPJF01000072_gene4354 3.66e-41 135.0 COG2501@1|root,COG2501@2|Bacteria,1VYQT@1239|Firmicutes,24QZU@186801|Clostridia,3Y0NB@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 yaaA - - ko:K14761 - - - - ko00000,ko03009 - - - S4_2 KKPNOBBG_04455 33035.JPJF01000072_gene4355 8.43e-249 684.0 COG0592@1|root,COG0592@2|Bacteria,1TQ7J@1239|Firmicutes,248EG@186801|Clostridia,3XZ49@572511|Blautia 186801|Clostridia L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 KKPNOBBG_04456 33035.JPJF01000072_gene4356 4.85e-306 836.0 COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,3XYQ0@572511|Blautia 186801|Clostridia L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N KKPNOBBG_04457 1235793.C809_01737 4.47e-18 75.5 COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia,27QHB@186928|unclassified Lachnospiraceae 186801|Clostridia J Ribosomal protein L34 rpmH - - ko:K02914 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L34 KKPNOBBG_04458 537007.BLAHAN_05902 2.14e-64 198.0 COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,3Y06S@572511|Blautia 186801|Clostridia J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P KKPNOBBG_04459 33035.JPJF01000072_gene4358 6.81e-286 783.0 COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,3XZCQ@572511|Blautia 186801|Clostridia U Psort location CytoplasmicMembrane, score yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP KKPNOBBG_04460 33035.JPJF01000072_gene4359 1e-151 432.0 COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3XZCW@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 jag - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H KKPNOBBG_04461 33035.JPJF01000072_gene4360 1.44e-295 810.0 COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,3XYJS@572511|Blautia 186801|Clostridia S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N KKPNOBBG_04462 33035.JPJF01000072_gene4361 0.0 1191.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,3XYJA@572511|Blautia 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc KKPNOBBG_04463 33035.JPJF01000072_gene4362 5.28e-159 447.0 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,3XYIZ@572511|Blautia 186801|Clostridia H Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB KKPNOBBG_04464 33035.JPJF01000072_gene4363 6.18e-206 570.0 COG0714@1|root,COG0714@2|Bacteria,1TQJA@1239|Firmicutes,249C6@186801|Clostridia,3Y1A2@572511|Blautia 186801|Clostridia S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA_5 KKPNOBBG_04465 33035.JPJF01000072_gene4364 0.0 1040.0 COG4548@1|root,COG4548@2|Bacteria,1TS8V@1239|Firmicutes,249FH@186801|Clostridia,3Y1CD@572511|Blautia 186801|Clostridia P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - CobT_C KKPNOBBG_04468 33035.JPJF01000072_gene4365 7.87e-112 323.0 2DNG8@1|root,32XC4@2|Bacteria,1VAW6@1239|Firmicutes,24QFT@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04469 33035.JPJF01000072_gene4366 4.43e-72 218.0 COG3695@1|root,COG3695@2|Bacteria,1VC8H@1239|Firmicutes,24N86@186801|Clostridia 186801|Clostridia L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 KKPNOBBG_04470 33035.JPJF01000072_gene4367 2.25e-216 598.0 COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3XZPU@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_04471 33035.JPJF01000072_gene4368 5.22e-178 499.0 COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,3XYVG@572511|Blautia 186801|Clostridia N Psort location CytoplasmicMembrane, score 9.99 - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5 KKPNOBBG_04472 33035.JPJF01000072_gene4369 3.88e-275 761.0 COG3225@1|root,COG3225@2|Bacteria,1TT1J@1239|Firmicutes,24BC2@186801|Clostridia,3XYR3@572511|Blautia 186801|Clostridia N ABC-type uncharacterized transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_transp_aux KKPNOBBG_04473 33035.JPJF01000072_gene4370 2.14e-260 727.0 2EDJE@1|root,337F9@2|Bacteria,1VHEB@1239|Firmicutes,24SR6@186801|Clostridia,3XZYW@572511|Blautia 186801|Clostridia S DNA topoisomerase IV subunit A K02621 - - - - - - - - - - - - DUF4340 KKPNOBBG_04474 33035.JPJF01000072_gene4371 2.17e-161 456.0 COG0596@1|root,COG0596@2|Bacteria,1TR3M@1239|Firmicutes,24DR9@186801|Clostridia,3XYQ9@572511|Blautia 186801|Clostridia S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 KKPNOBBG_04475 33035.JPJF01000072_gene4372 1.09e-176 493.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,3XYPE@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 KKPNOBBG_04476 33035.JPJF01000072_gene4373 1.15e-191 535.0 COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3XZNQ@572511|Blautia 186801|Clostridia K chromosome partitioning protein spo0J - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc KKPNOBBG_04477 33035.JPJF01000072_gene4374 1.17e-100 293.0 COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia,3XZYE@572511|Blautia 186801|Clostridia D Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4446 KKPNOBBG_04478 33035.JPJF01000072_gene4375 2.35e-303 827.0 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,3XYK5@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b KKPNOBBG_04479 33035.JPJF01000072_gene4376 7.89e-206 569.0 28J5A@1|root,2Z916@2|Bacteria,1TSGX@1239|Firmicutes,24AZU@186801|Clostridia,3XZ0E@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF3881 KKPNOBBG_04480 33035.JPJF01000072_gene4377 0.0 2588.0 COG2199@1|root,COG2200@1|root,COG2202@1|root,COG5001@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3XZE8@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 KKPNOBBG_04481 33035.JPJF01000072_gene4378 0.0 1015.0 COG2972@1|root,COG2972@2|Bacteria,1TT1G@1239|Firmicutes,2495G@186801|Clostridia,3Y2A3@572511|Blautia 186801|Clostridia T Cache domain - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_04482 33035.JPJF01000072_gene4379 2.69e-153 432.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V2PT@1239|Firmicutes,24H78@186801|Clostridia,3Y1TI@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_04483 33035.JPJF01000072_gene4380 1.72e-296 811.0 COG1653@1|root,COG1653@2|Bacteria,1TT8P@1239|Firmicutes,24DVQ@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04484 33035.JPJF01000072_gene4381 5.17e-199 555.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,24C7D@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04485 33035.JPJF01000072_gene4382 4.7e-178 498.0 COG0395@1|root,COG0395@2|Bacteria,1TPDZ@1239|Firmicutes,248N3@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04486 33035.JPJF01000072_gene4383 1e-138 394.0 COG2755@1|root,COG2755@2|Bacteria,1V49F@1239|Firmicutes,24D1K@186801|Clostridia,3Y0I8@572511|Blautia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_04487 33035.JPJF01000072_gene4384 1.31e-212 596.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,3Y0HZ@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_04488 33035.JPJF01000072_gene4385 1.6e-22 95.9 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HD_4,HTH_3 KKPNOBBG_04489 552398.HMPREF0866_00587 5.25e-53 181.0 2ADE4@1|root,31340@2|Bacteria,1V962@1239|Firmicutes,24GN3@186801|Clostridia,3WPIY@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04490 411468.CLOSCI_00174 2.03e-23 91.3 2CZEX@1|root,32T68@2|Bacteria,1VB18@1239|Firmicutes,24MZP@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04491 658086.HMPREF0994_06810 6.01e-269 736.0 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,27JNQ@186928|unclassified Lachnospiraceae 186801|Clostridia M Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,Rhodanese,SelR KKPNOBBG_04492 658086.HMPREF0994_06606 1.69e-27 109.0 COG3547@1|root,COG3547@2|Bacteria,1TPSP@1239|Firmicutes,24AH4@186801|Clostridia,27TFA@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 KKPNOBBG_04493 658086.HMPREF0994_06606 8.78e-80 247.0 COG3547@1|root,COG3547@2|Bacteria,1TPSP@1239|Firmicutes,24AH4@186801|Clostridia,27TFA@186928|unclassified Lachnospiraceae 186801|Clostridia L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 KKPNOBBG_04494 658086.HMPREF0994_06809 5.75e-207 575.0 COG0526@1|root,COG0526@2|Bacteria,1UY9A@1239|Firmicutes,24C03@186801|Clostridia,27PXB@186928|unclassified Lachnospiraceae 186801|Clostridia CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin KKPNOBBG_04495 658086.HMPREF0994_06808 1.97e-201 559.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,27K6Y@186928|unclassified Lachnospiraceae 186801|Clostridia C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_5 KKPNOBBG_04496 658086.HMPREF0994_06807 9.8e-19 77.8 2EHC1@1|root,33B3W@2|Bacteria,1UG66@1239|Firmicutes,25AIM@186801|Clostridia,27QIC@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04497 718252.FP2_23710 1.37e-149 422.0 COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia,3WH9J@541000|Ruminococcaceae 186801|Clostridia K Psort location Cytoplasmic, score cutR - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_04498 658086.HMPREF0994_06805 1.52e-248 685.0 COG5002@1|root,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,25FJK@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_04499 411483.FAEPRAA2165_00066 1.13e-43 144.0 2AZMT@1|root,31RWJ@2|Bacteria,1V7QQ@1239|Firmicutes,25CZU@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_04500 903814.ELI_1145 1.15e-211 593.0 COG1191@1|root,COG1191@2|Bacteria,1U0Q7@1239|Firmicutes,249NN@186801|Clostridia,25VKH@186806|Eubacteriaceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_04501 1507.HMPREF0262_00649 7.07e-205 574.0 28ICW@1|root,2Z8F5@2|Bacteria,1TSMN@1239|Firmicutes,24BRU@186801|Clostridia,36R2M@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04502 1507.HMPREF0262_00650 1.81e-58 187.0 COG0358@1|root,COG0358@2|Bacteria,1V0WR@1239|Firmicutes,24C9Q@186801|Clostridia,36R88@31979|Clostridiaceae 186801|Clostridia L CHC2 zinc finger - - - - - - - - - - - - zf-CHC2 KKPNOBBG_04503 1232453.BAIF02000019_gene3935 5.4e-255 706.0 COG3378@1|root,COG3378@2|Bacteria,1TSGZ@1239|Firmicutes,24CI8@186801|Clostridia,267MA@186813|unclassified Clostridiales 186801|Clostridia S Phage plasmid primase, P4 family domain protein - - - ko:K06919 - - - - ko00000 - - - D5_N KKPNOBBG_04504 552396.HMPREF0863_04163 1.8e-38 129.0 2DRW8@1|root,32URU@2|Bacteria,1VA9A@1239|Firmicutes 1239|Firmicutes - - - - - - - - - - - - - - - KKPNOBBG_04505 1507.HMPREF0262_00653 6.35e-217 609.0 COG1196@1|root,COG1196@2|Bacteria,1UQCD@1239|Firmicutes,24AY9@186801|Clostridia,36FC6@31979|Clostridiaceae 186801|Clostridia D Plasmid recombination enzyme - - - - - - - - - - - - Mob_Pre KKPNOBBG_04506 1507.HMPREF0262_00654 2.05e-38 131.0 2C3T4@1|root,32S28@2|Bacteria,1VB78@1239|Firmicutes,24NAY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04507 1507.HMPREF0262_00655 3.83e-309 851.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,36DU1@31979|Clostridiaceae 186801|Clostridia L Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_04508 33035.JPJF01000072_gene4385 8.01e-117 358.0 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HD_4,HTH_3 KKPNOBBG_04509 476272.RUMHYD_03247 1.88e-47 164.0 COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,3Y0PQ@572511|Blautia 186801|Clostridia K Psort location - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR KKPNOBBG_04510 768706.Desor_1124 1.89e-100 312.0 COG2271@1|root,COG2271@2|Bacteria,1TPYW@1239|Firmicutes,25DRD@186801|Clostridia,2679E@186807|Peptococcaceae 186801|Clostridia G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_04511 1151292.QEW_2983 6.21e-25 94.4 COG2221@1|root,COG2221@2|Bacteria,1VI3X@1239|Firmicutes,24TQ6@186801|Clostridia 186801|Clostridia C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_7 KKPNOBBG_04512 33035.JPJF01000051_gene747 8.2e-179 506.0 COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3Y1C2@572511|Blautia 186801|Clostridia C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N KKPNOBBG_04513 865861.AZSU01000003_gene2296 1.93e-116 340.0 COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,36DRF@31979|Clostridiaceae 186801|Clostridia C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C KKPNOBBG_04514 568816.Acin_0623 2.26e-77 235.0 COG1014@1|root,COG1014@2|Bacteria,1V39Q@1239|Firmicutes,4H97S@909932|Negativicutes 909932|Negativicutes C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.3 ko:K00177 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR KKPNOBBG_04515 332101.JIBU02000056_gene2632 2.79e-295 830.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,36GU1@31979|Clostridiaceae 186801|Clostridia C Succinyl-CoA ligase like flavodoxin domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig KKPNOBBG_04516 33035.JPJF01000016_gene4080 1.34e-167 488.0 COG0591@1|root,COG0591@2|Bacteria,1U2RB@1239|Firmicutes,25MU7@186801|Clostridia,3Y1RI@572511|Blautia 186801|Clostridia E Sodium:solute symporter family - - - - - - - - - - - - SSF KKPNOBBG_04517 33035.JPJF01000016_gene4079 1.12e-106 321.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3XYQ8@572511|Blautia 186801|Clostridia CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_04518 1195236.CTER_1674 1.35e-139 425.0 COG2972@1|root,COG2972@2|Bacteria,1TQZM@1239|Firmicutes,247ZV@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase KKPNOBBG_04519 1195236.CTER_1673 2.47e-99 317.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia 186801|Clostridia T response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04520 1195236.CTER_1672 9.23e-56 178.0 COG1661@1|root,COG1661@2|Bacteria,1V67W@1239|Firmicutes,24J3Y@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF296) - - - ko:K06934 - - - - ko00000 - - - DUF296 KKPNOBBG_04521 1195236.CTER_1671 2.98e-177 511.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia,3WJP9@541000|Ruminococcaceae 186801|Clostridia G Extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04522 1195236.CTER_1670 1.5e-120 354.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia 186801|Clostridia P ABC-type sugar transport system, permease component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04523 1195236.CTER_1669 6.41e-128 372.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04524 1121085.AUCI01000001_gene3716 9.33e-81 248.0 COG0684@1|root,COG0684@2|Bacteria,1UZ9U@1239|Firmicutes,4IP4T@91061|Bacilli,1ZPDM@1386|Bacillus 91061|Bacilli H Aldolase/RraA - - - - - - - - - - - - RraA-like KKPNOBBG_04526 1195236.CTER_1677 6.49e-226 646.0 COG2730@1|root,COG2730@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - - - - - - - - - - - BACON,CW_binding_1,Cellulase,DUF4038,DUF5060 KKPNOBBG_04527 553973.CLOHYLEM_05928 4.07e-185 520.0 COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,2488D@186801|Clostridia,21YFJ@1506553|Lachnoclostridium 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.121 ko:K05878 ko00561,ko01100,map00561,map01100 - R01012 RC00015,RC00017 ko00000,ko00001,ko01000 - - - Dak1 KKPNOBBG_04528 553973.CLOHYLEM_05803 1.21e-81 249.0 COG1461@1|root,COG1461@2|Bacteria,1V4FH@1239|Firmicutes,24FUX@186801|Clostridia 186801|Clostridia S Dihydroxyacetone kinase, L subunit - - 2.7.1.121 ko:K05879 ko00561,ko01100,map00561,map01100 - R01012 RC00015,RC00017 ko00000,ko00001,ko01000 - - - Dak2 KKPNOBBG_04529 553973.CLOHYLEM_05761 4.21e-69 212.0 COG0698@1|root,COG0698@2|Bacteria,1V2VV@1239|Firmicutes,24GCM@186801|Clostridia,222T7@1506553|Lachnoclostridium 186801|Clostridia G Sugar-phosphate isomerase, RpiB LacA LacB family - - - - - - - - - - - - LacAB_rpiB KKPNOBBG_04530 1408324.JNJK01000002_gene3407 1.05e-144 420.0 28IPH@1|root,2Z8PG@2|Bacteria,1TREB@1239|Firmicutes,248QM@186801|Clostridia,27KR2@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04531 1226325.HMPREF1548_01647 7.59e-198 554.0 COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,36IPH@31979|Clostridiaceae 186801|Clostridia C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_04532 1226325.HMPREF1548_01646 0.0 1670.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae 186801|Clostridia C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C KKPNOBBG_04533 592015.HMPREF1705_02127 2.74e-11 65.9 COG2721@1|root,COG2721@2|Bacteria,3T9UT@508458|Synergistetes 508458|Synergistetes G SAF - - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF KKPNOBBG_04534 1226325.HMPREF1548_01644 2.66e-205 576.0 COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,36G4P@31979|Clostridiaceae 186801|Clostridia G D-galactarate dehydratase altronate hydrolase - - 4.2.1.7 ko:K16850 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C KKPNOBBG_04535 1226325.HMPREF1548_01643 5.69e-293 806.0 COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae 186801|Clostridia Q 4-hydroxyphenylacetate 3-hydroxylase C terminal abfD - 1.14.14.9,4.2.1.120,5.3.3.3 ko:K00483,ko:K14534 ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220 M00374,M00375 R02698,R03031,R03299,R10782 RC00046,RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N KKPNOBBG_04536 658086.HMPREF0994_05391 8.19e-221 616.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,27J2B@186928|unclassified Lachnospiraceae 186801|Clostridia I Thiolase, C-terminal domain thlA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N KKPNOBBG_04537 397287.C807_03746 2.84e-118 345.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,27IZZ@186928|unclassified Lachnospiraceae 186801|Clostridia I Enoyl-CoA hydratase/isomerase crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 KKPNOBBG_04538 1163671.JAGI01000002_gene2320 3.23e-133 385.0 COG1250@1|root,COG1250@2|Bacteria,1TPJS@1239|Firmicutes,248AE@186801|Clostridia,36DG5@31979|Clostridiaceae 186801|Clostridia I Dehydrogenase hbd - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N KKPNOBBG_04539 1235800.C819_01175 2.33e-155 449.0 COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,27K1G@186928|unclassified Lachnospiraceae 186801|Clostridia I Acyl-CoA dehydrogenase, C-terminal domain bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N KKPNOBBG_04541 33035.JPJF01000104_gene2580 0.0 1026.0 COG4447@1|root,COG4733@1|root,COG4447@2|Bacteria,COG4733@2|Bacteria 2|Bacteria S cellulase activity - GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.11.1,3.2.1.4,3.2.1.78 ko:K01179,ko:K01218,ko:K12132 ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024 - R01332,R06200,R11307,R11308 RC00467 ko00000,ko00001,ko01000,ko01001 - GH26,GH5,GH9 - CBM_2,CBM_3,Dockerin_1,Glyco_hydro_9,fn3 KKPNOBBG_04543 33035.JPJF01000104_gene2579 0.0 1071.0 COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3XYYP@572511|Blautia 186801|Clostridia P COG COG0004 Ammonia permease - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,P-II KKPNOBBG_04544 33035.JPJF01000104_gene2578 0.0 900.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3XYNJ@572511|Blautia 186801|Clostridia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran KKPNOBBG_04545 33035.JPJF01000104_gene2577 0.0 1299.0 COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3XZ1H@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C KKPNOBBG_04546 877414.ATWA01000041_gene1535 1.74e-211 590.0 COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,26A52@186813|unclassified Clostridiales 186801|Clostridia C Acetokinase family buk - 2.7.2.7 ko:K00929 ko00650,ko01100,map00650,map01100 - R01688 RC00002,RC00043 ko00000,ko00001,ko01000 - - - Acetate_kinase KKPNOBBG_04547 877414.ATWA01000013_gene2354 7.77e-192 538.0 COG0280@1|root,COG0280@2|Bacteria,1TS7B@1239|Firmicutes,2496E@186801|Clostridia,26CM4@186813|unclassified Clostridiales 186801|Clostridia C Phosphate acetyl/butaryl transferase - - 2.3.1.8 ko:K00625 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - - PTA_PTB KKPNOBBG_04548 97139.C824_03840 3.37e-50 161.0 COG4922@1|root,COG4922@2|Bacteria,1VEC0@1239|Firmicutes,24JEI@186801|Clostridia,36PYK@31979|Clostridiaceae 186801|Clostridia S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL KKPNOBBG_04549 658655.HMPREF0988_01431 5.05e-188 545.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,27UFA@186928|unclassified Lachnospiraceae 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 KKPNOBBG_04550 658655.HMPREF0988_01430 5.05e-159 453.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,27N0H@186928|unclassified Lachnospiraceae 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04551 556261.HMPREF0240_00603 2.84e-178 501.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae 186801|Clostridia EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N KKPNOBBG_04552 658655.HMPREF0988_01428 1.15e-180 509.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,27JHK@186928|unclassified Lachnospiraceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY KKPNOBBG_04553 658655.HMPREF0988_01427 1.45e-196 548.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,27JBD@186928|unclassified Lachnospiraceae 186801|Clostridia P Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY KKPNOBBG_04554 588581.Cpap_2813 3.67e-281 776.0 COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,3WHHS@541000|Ruminococcaceae 186801|Clostridia C domain protein - - - - - - - - - - - - FAD_binding_2,FMN_bind KKPNOBBG_04555 97139.C824_03811 1.09e-244 709.0 COG3664@1|root,COG4977@1|root,COG3664@2|Bacteria,COG4977@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae 186801|Clostridia K family 39 - - - - - - - - - - - - AraC_binding,Cupin_2,Glyco_hydro_39,HTH_18 KKPNOBBG_04556 556261.HMPREF0240_00635 2.05e-166 473.0 COG0655@1|root,COG0655@2|Bacteria,1UYDQ@1239|Firmicutes,24BAR@186801|Clostridia,36H9Z@31979|Clostridiaceae 186801|Clostridia S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red KKPNOBBG_04557 877411.JMMA01000002_gene1886 2.29e-12 70.9 COG2091@1|root,COG2091@2|Bacteria,1VEYZ@1239|Firmicutes,24RQ3@186801|Clostridia,3WM4E@541000|Ruminococcaceae 186801|Clostridia H 4'-phosphopantetheinyl transferase superfamily sfp - - ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS KKPNOBBG_04558 931276.Cspa_c47630 1.63e-172 513.0 COG3711@1|root,COG3711@2|Bacteria,1TQT1@1239|Firmicutes,249R8@186801|Clostridia 186801|Clostridia GKT Psort location Cytoplasmic, score - - - ko:K03491 - - - - ko00000,ko03000 - - - HTH_11,Mga,PRD,PTS_EIIA_2 KKPNOBBG_04559 588581.Cpap_2791 1.63e-191 541.0 COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,249X1@186801|Clostridia,3WJCU@541000|Ruminococcaceae 186801|Clostridia C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH KKPNOBBG_04560 97139.C824_03947 2.17e-141 414.0 COG0477@1|root,COG2814@2|Bacteria,1UZXR@1239|Firmicutes,25CFX@186801|Clostridia,36WVE@31979|Clostridiaceae 186801|Clostridia EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_04561 588581.Cpap_2788 2.24e-211 588.0 COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia,3WIUB@541000|Ruminococcaceae 186801|Clostridia C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.310 ko:K16843 ko00270,map00270 - R05693 RC00031 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_04562 411490.ANACAC_03806 1.53e-98 292.0 COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia 186801|Clostridia G L-ribulose-5-phosphate 4-epimerase - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II KKPNOBBG_04563 1280698.AUJS01000039_gene2452 4.44e-264 736.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,27WE7@189330|Dorea 186801|Clostridia G FGGY family of carbohydrate kinases, N-terminal domain - - - - - - - - - - - - FGGY_C,FGGY_N KKPNOBBG_04565 1042156.CXIVA_15980 1.22e-122 360.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia,36GBX@31979|Clostridiaceae 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_04566 1123304.AQYA01000023_gene1494 3.58e-39 137.0 COG0346@1|root,COG0346@2|Bacteria,1VK1Y@1239|Firmicutes 1239|Firmicutes E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 KKPNOBBG_04567 588581.Cpap_2805 6.05e-117 347.0 COG0667@1|root,COG0667@2|Bacteria,1TQYY@1239|Firmicutes,24JUU@186801|Clostridia,3WGRS@541000|Ruminococcaceae 186801|Clostridia C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_04568 1232436.CAPF01000040_gene408 1.49e-236 659.0 COG0183@1|root,COG0183@2|Bacteria,2HQJS@201174|Actinobacteria,4CUEK@84998|Coriobacteriia 84998|Coriobacteriia I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N KKPNOBBG_04569 1232436.CAPF01000040_gene407 5.11e-57 181.0 COG1545@1|root,COG1545@2|Bacteria,2HVHS@201174|Actinobacteria,4CWVA@84998|Coriobacteriia 84998|Coriobacteriia S DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - - KKPNOBBG_04571 1256908.HMPREF0373_02736 0.0 1082.0 COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,25UR0@186806|Eubacteriaceae 186801|Clostridia C NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - - - - - - - - - - - Fer2_4,Fer4,Fer4_20,Fer4_7,NADH-G_4Fe-4S_3,Pyr_redox_2 KKPNOBBG_04572 588581.Cpap_2811 2.51e-124 373.0 COG1145@1|root,COG1894@1|root,COG1145@2|Bacteria,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WGG2@541000|Ruminococcaceae 186801|Clostridia C NADH ubiquinone oxidoreductase - - - - - - - - - - - - Fer4,NADH_4Fe-4S KKPNOBBG_04573 588581.Cpap_2799 6.14e-214 593.0 COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24DB5@186801|Clostridia 186801|Clostridia G AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N KKPNOBBG_04574 588581.Cpap_2798 7.17e-222 618.0 COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24CB6@186801|Clostridia,3WRKP@541000|Ruminococcaceae 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04575 1235798.C817_03144 0.0 974.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,27W9G@189330|Dorea 186801|Clostridia C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN,Pyr_redox_2 KKPNOBBG_04576 33035.JPJF01000017_gene3824 0.0 1026.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,3XZPG@572511|Blautia 186801|Clostridia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase KKPNOBBG_04577 33035.JPJF01000017_gene3823 0.0 2848.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,3XZ2S@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase KKPNOBBG_04578 33035.JPJF01000017_gene3822 0.0 949.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3XZHX@572511|Blautia 186801|Clostridia C NADH-dependent glutamate synthase small subunit gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 KKPNOBBG_04579 33035.JPJF01000017_gene3821 7.15e-288 787.0 COG0407@1|root,COG0407@2|Bacteria,1TRJG@1239|Firmicutes,24B34@186801|Clostridia 186801|Clostridia H PFAM Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04580 33035.JPJF01000017_gene3820 0.0 1113.0 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,3XYQ1@572511|Blautia 186801|Clostridia L RQC recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind KKPNOBBG_04582 1123075.AUDP01000015_gene3376 3.48e-48 159.0 2FDHY@1|root,345JE@2|Bacteria,1W104@1239|Firmicutes,24T1V@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04583 33035.JPJF01000017_gene3818 4.94e-160 451.0 COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,3Y0V5@572511|Blautia 186801|Clostridia NOU Type IV leader peptidase family pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 KKPNOBBG_04584 33035.JPJF01000017_gene3817 1.42e-244 677.0 COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,3Y1N8@572511|Blautia 186801|Clostridia NU Type II secretion system (T2SS), protein F - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF KKPNOBBG_04585 33035.JPJF01000017_gene3816 4.05e-297 817.0 COG4972@1|root,COG4972@2|Bacteria,1V5EN@1239|Firmicutes,25CNU@186801|Clostridia 186801|Clostridia NU Pilus assembly protein - - - - - - - - - - - - - KKPNOBBG_04586 33035.JPJF01000017_gene3815 3.16e-119 346.0 2E6F2@1|root,3312H@2|Bacteria,1VJ78@1239|Firmicutes,24JWX@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - T2SSM KKPNOBBG_04587 33035.JPJF01000017_gene3814 0.0 987.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3Y18R@572511|Blautia 186801|Clostridia NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N KKPNOBBG_04588 33035.JPJF01000017_gene3813 4.07e-233 644.0 COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,3XYY6@572511|Blautia 186801|Clostridia NU Type II/IV secretion system protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE KKPNOBBG_04589 33035.JPJF01000017_gene3812 0.0 2401.0 COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,1TPP4@1239|Firmicutes,24EQB@186801|Clostridia 186801|Clostridia U Pkd domain containing protein - - - - - - - - - - - - N_methyl KKPNOBBG_04590 1123075.AUDP01000015_gene3384 3.1e-54 181.0 2EU5X@1|root,33MNH@2|Bacteria,1VQRM@1239|Firmicutes,24RQW@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04592 1120998.AUFC01000002_gene2726 2.2e-42 155.0 COG2165@1|root,COG2165@2|Bacteria,1VGTY@1239|Firmicutes,24T0W@186801|Clostridia 186801|Clostridia NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl KKPNOBBG_04593 33035.JPJF01000017_gene3808 1.62e-310 847.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,3XYYT@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 9.98 glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N KKPNOBBG_04594 33035.JPJF01000017_gene3807 1.21e-111 322.0 COG3707@1|root,COG3707@2|Bacteria,1V2S1@1239|Firmicutes,24EWG@186801|Clostridia,3Y020@572511|Blautia 186801|Clostridia K ANTAR - - - ko:K22010 - M00839 - - ko00000,ko00002,ko02022 - - - ANTAR KKPNOBBG_04595 33035.JPJF01000017_gene3806 3.56e-301 820.0 COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,24969@186801|Clostridia,3XYT4@572511|Blautia 186801|Clostridia H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_04596 33035.JPJF01000017_gene3805 3.41e-296 811.0 COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,248XN@186801|Clostridia,3XZ7F@572511|Blautia 186801|Clostridia J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12,6.1.1.23 ko:K01876,ko:K09759 ko00970,map00970 M00359,M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_2,tRNA_anti-codon KKPNOBBG_04597 33035.JPJF01000017_gene3804 2.07e-42 140.0 COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,24RIE@186801|Clostridia,3Y0HE@572511|Blautia 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln KKPNOBBG_04598 33035.JPJF01000017_gene3803 0.0 877.0 COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,3XZNT@572511|Blautia 186801|Clostridia H Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase KKPNOBBG_04599 33035.JPJF01000017_gene3802 0.0 880.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,3XYZ1@572511|Blautia 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey KKPNOBBG_04600 33035.JPJF01000017_gene3801 1.21e-121 355.0 COG0568@1|root,COG0568@2|Bacteria,1VJ02@1239|Firmicutes,24RNB@186801|Clostridia,3Y0EP@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r2 KKPNOBBG_04601 33035.JPJF01000017_gene3800 5.91e-133 379.0 COG0491@1|root,COG0491@2|Bacteria,1V2P7@1239|Firmicutes,24KQT@186801|Clostridia 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B KKPNOBBG_04602 33035.JPJF01000017_gene3799 0.0 1107.0 COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,3XZ55@572511|Blautia 186801|Clostridia O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 KKPNOBBG_04603 33035.JPJF01000017_gene3796 5.9e-297 813.0 COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia,3XYP4@572511|Blautia 186801|Clostridia F Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - Xan_ur_permease KKPNOBBG_04604 33035.JPJF01000017_gene3795 5.23e-230 633.0 COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia,3XYID@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - RNase_T KKPNOBBG_04605 33035.JPJF01000017_gene3786 8.47e-301 828.0 COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3XYN4@572511|Blautia 186801|Clostridia M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 KKPNOBBG_04606 33035.JPJF01000017_gene3785 8.82e-311 853.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3Y1R1@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04607 33035.JPJF01000017_gene3784 0.0 1019.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_04608 33035.JPJF01000017_gene3783 2.33e-314 857.0 COG1653@1|root,COG1653@2|Bacteria,1V26U@1239|Firmicutes,24HG9@186801|Clostridia 186801|Clostridia G ABC transporter, solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_04609 33035.JPJF01000017_gene3782 4.4e-215 594.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,24CKT@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04610 33035.JPJF01000017_gene3781 3.99e-184 514.0 COG0395@1|root,COG0395@2|Bacteria,1V1ZI@1239|Firmicutes,24GHY@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04611 33035.JPJF01000017_gene3780 0.0 1632.0 COG4354@1|root,COG4354@2|Bacteria,1TR78@1239|Firmicutes,247UY@186801|Clostridia 186801|Clostridia G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - - - - - - - - - - - DUF608,Glyco_hydr_116N KKPNOBBG_04612 33035.JPJF01000017_gene3779 9.2e-268 732.0 COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia,3XYWH@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 KKPNOBBG_04613 33035.JPJF01000017_gene3778 1.75e-73 221.0 COG1725@1|root,COG1725@2|Bacteria,1VAC6@1239|Firmicutes,24MVE@186801|Clostridia,3Y0QJ@572511|Blautia 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - GntR KKPNOBBG_04614 33035.JPJF01000017_gene3777 1.74e-195 543.0 COG1131@1|root,COG1131@2|Bacteria,1TS5Y@1239|Firmicutes,24AH1@186801|Clostridia,3Y0DV@572511|Blautia 186801|Clostridia V Psort location - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_04616 33035.JPJF01000017_gene3775 5.84e-129 370.0 2DRS1@1|root,33CTC@2|Bacteria,1VPFR@1239|Firmicutes,24X55@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04617 500632.CLONEX_00407 1.16e-223 627.0 COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia 186801|Clostridia G solute-binding protein lacE - - ko:K10188 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04618 500632.CLONEX_00406 4.41e-158 449.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K10189 ko02010,map02010 M00199,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_04619 500632.CLONEX_00405 1.5e-150 429.0 COG0395@1|root,COG0395@2|Bacteria,1TSGI@1239|Firmicutes,24BDH@186801|Clostridia 186801|Clostridia P binding-protein-dependent transport systems inner membrane component - - - ko:K10190 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_04620 500632.CLONEX_00403 9.39e-178 516.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSN6@1239|Firmicutes,24D7T@186801|Clostridia 186801|Clostridia T response regulator - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_04621 500632.CLONEX_00402 2.35e-196 570.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,248RT@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_04622 1121346.KB899852_gene118 6.31e-139 434.0 COG0383@1|root,COG0383@2|Bacteria,1V5JH@1239|Firmicutes,4HRTD@91061|Bacilli,26VZF@186822|Paenibacillaceae 91061|Bacilli G Domain of unknown function (DUF5054) - - - - - - - - - - - - DUF5054,Glyco_hydro_38 KKPNOBBG_04623 742765.HMPREF9457_02920 5.32e-34 117.0 COG3655@1|root,COG3655@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - DUF4384,HTH_26,HTH_3 KKPNOBBG_04624 1236976.JCM16418_4883 8.37e-73 236.0 COG4260@1|root,COG4260@2|Bacteria,1TRYU@1239|Firmicutes,4HE99@91061|Bacilli,275JE@186822|Paenibacillaceae 91061|Bacilli L Antifreeze protein type I - - - - - - - - - - - - Band_7_1,DZR,SHOCT KKPNOBBG_04626 476272.RUMHYD_01979 1.01e-26 114.0 29XIW@1|root,30J9V@2|Bacteria,1W3YF@1239|Firmicutes,256PY@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04627 33035.JPJF01000017_gene3763 0.0 2133.0 COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,3XZEW@572511|Blautia 186801|Clostridia J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 KKPNOBBG_04628 33035.JPJF01000017_gene3762 0.0 1631.0 COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,3XZEY@572511|Blautia 186801|Clostridia G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase KKPNOBBG_04629 742740.HMPREF9474_00405 1.99e-112 333.0 COG0583@1|root,COG0583@2|Bacteria,1TP77@1239|Firmicutes,248CX@186801|Clostridia,22480@1506553|Lachnoclostridium 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04630 293826.Amet_0661 2.45e-105 328.0 COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,36DHD@31979|Clostridiaceae 186801|Clostridia S C4-dicarboxylate anaerobic carrier - - - - - - - - - - - - DcuC KKPNOBBG_04631 742740.HMPREF9474_01860 4.2e-114 352.0 COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24F7T@186801|Clostridia,223X8@1506553|Lachnoclostridium 186801|Clostridia E Peptidase family M20/M25/M40 - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_04632 411483.FAEPRAA2165_01167 2.7e-89 275.0 COG0679@1|root,COG0679@2|Bacteria,1V24M@1239|Firmicutes,25CB9@186801|Clostridia,3WSBZ@541000|Ruminococcaceae 186801|Clostridia S Sodium Bile acid symporter family - - - ko:K07088 - - - - ko00000 - - - Mem_trans KKPNOBBG_04633 33035.JPJF01000017_gene3761 0.0 1162.0 COG0457@1|root,COG0464@1|root,COG0457@2|Bacteria,COG0464@2|Bacteria,1TY3C@1239|Firmicutes,248IE@186801|Clostridia,3XZJN@572511|Blautia 186801|Clostridia O Psort location Cytoplasmic, score 8.87 SpoVK - - - - - - - - - - - TPR_8 KKPNOBBG_04634 33035.JPJF01000017_gene3760 7.29e-195 542.0 COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,3XZGB@572511|Blautia 186801|Clostridia J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD KKPNOBBG_04635 33035.JPJF01000017_gene3759 9.71e-148 417.0 COG1418@1|root,COG1418@2|Bacteria,1UI0F@1239|Firmicutes,24GIY@186801|Clostridia,3XZYU@572511|Blautia 186801|Clostridia S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K09163 - - - - ko00000 - - - HD KKPNOBBG_04636 742765.HMPREF9457_02961 1.09e-240 672.0 COG1875@1|root,COG1875@2|Bacteria,1UHTD@1239|Firmicutes,25ED1@186801|Clostridia,27WFV@189330|Dorea 186801|Clostridia T ATPase related to phosphate starvation-inducible protein PhoH phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH KKPNOBBG_04637 33035.JPJF01000017_gene3758 9.33e-177 493.0 COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,249SV@186801|Clostridia,3Y1GY@572511|Blautia 186801|Clostridia E ATPases associated with a variety of cellular activities - - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran KKPNOBBG_04638 33035.JPJF01000017_gene3757 0.0 942.0 COG1178@1|root,COG1178@2|Bacteria,1UXJF@1239|Firmicutes,25M9I@186801|Clostridia,3Y14J@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04639 33035.JPJF01000017_gene3756 3.1e-221 611.0 COG1840@1|root,COG1840@2|Bacteria,1TT3Y@1239|Firmicutes,24AJP@186801|Clostridia 186801|Clostridia P Bacterial extracellular solute-binding protein - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1,SBP_bac_6 KKPNOBBG_04640 33035.JPJF01000017_gene3755 2.48e-254 698.0 COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,3Y0X5@572511|Blautia 186801|Clostridia E Cys/Met metabolism PLP-dependent enzyme phnW - 2.6.1.37,3.11.1.1 ko:K03430,ko:K05306 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R00747,R04152 RC00008,RC00062,RC00368 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5,HAD_2 KKPNOBBG_04641 33035.JPJF01000017_gene3754 4.92e-167 468.0 COG0637@1|root,COG0637@2|Bacteria,1TP1A@1239|Firmicutes,24CZD@186801|Clostridia,3Y14W@572511|Blautia 186801|Clostridia S Haloacid dehalogenase-like hydrolase phnX - 3.11.1.1 ko:K05306 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R00747 RC00368 ko00000,ko00001,ko01000 - - - HAD_2 KKPNOBBG_04642 33035.JPJF01000017_gene3753 3.17e-251 693.0 COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,24GF0@186801|Clostridia,3Y1Q2@572511|Blautia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC KKPNOBBG_04643 33035.JPJF01000017_gene3752 0.0 1182.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,3Y1VI@572511|Blautia 186801|Clostridia G Glycosyl hydrolases family 2, sugar binding domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_04644 33035.JPJF01000017_gene3751 4.78e-288 793.0 COG2211@1|root,COG2211@2|Bacteria,1TRYR@1239|Firmicutes,25C8G@186801|Clostridia,3XZ0S@572511|Blautia 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_04645 33035.JPJF01000017_gene3750 1.36e-265 729.0 COG1940@1|root,COG1940@2|Bacteria,1TQCE@1239|Firmicutes,24AE3@186801|Clostridia,3Y2BB@572511|Blautia 186801|Clostridia K MarR family xylR - - - - - - - - - - - HTH_24,MarR_2,ROK KKPNOBBG_04646 33035.JPJF01000017_gene3749 1.08e-167 474.0 COG4086@1|root,COG4086@2|Bacteria,1TR2I@1239|Firmicutes,24C10@186801|Clostridia,3XZRQ@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF1002) - - - - - - - - - - - - DUF1002 KKPNOBBG_04647 33035.JPJF01000017_gene3748 3.03e-149 420.0 COG2357@1|root,COG2357@2|Bacteria,1TSC9@1239|Firmicutes,25CET@186801|Clostridia,3XZH1@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 spoT - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT KKPNOBBG_04648 33035.JPJF01000017_gene3747 1.13e-223 619.0 COG3641@1|root,COG3641@2|Bacteria,1TS5F@1239|Firmicutes,247P0@186801|Clostridia,3XZ5V@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - ko:K07035 - - - - ko00000 - - - PTS_EIIC_2 KKPNOBBG_04649 33035.JPJF01000017_gene3746 9.96e-152 428.0 COG0539@1|root,COG0539@2|Bacteria,1UYC5@1239|Firmicutes,24AJ1@186801|Clostridia,3XZE6@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 9.98 rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 KKPNOBBG_04650 33035.JPJF01000054_gene1623 0.0 1062.0 COG1227@1|root,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,3XYRG@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score 8.87 ppaC - 3.6.1.1 ko:K15986 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - CBS,DHH,DHHA2,DRTGG KKPNOBBG_04651 33035.JPJF01000054_gene1624 0.0 961.0 COG1501@1|root,COG1501@2|Bacteria,1TSIW@1239|Firmicutes,24DS5@186801|Clostridia 186801|Clostridia G Glycosyl hydrolases family 31 - - - - - - - - - - - - Glyco_hydro_31 KKPNOBBG_04652 33035.JPJF01000054_gene1625 1.94e-136 386.0 COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3XYRI@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Flavin_Reduct KKPNOBBG_04653 33035.JPJF01000054_gene1626 1.15e-104 303.0 COG0703@1|root,COG0703@2|Bacteria,1V3W6@1239|Firmicutes,24HKA@186801|Clostridia,3Y00E@572511|Blautia 186801|Clostridia F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI KKPNOBBG_04654 33035.JPJF01000054_gene1627 1.84e-298 815.0 COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,3XZ1V@572511|Blautia 186801|Clostridia M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase KKPNOBBG_04655 33035.JPJF01000054_gene1628 6.89e-195 541.0 COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1V5FF@1239|Firmicutes,25B27@186801|Clostridia 186801|Clostridia K Bacterial transcription activator, effector binding domain - - - ko:K13653 - - - - ko00000,ko03000 - - - Cass2,HTH_18 KKPNOBBG_04656 33035.JPJF01000054_gene1629 3e-91 278.0 COG4886@1|root,COG4886@2|Bacteria,1V44C@1239|Firmicutes,25EA1@186801|Clostridia,3Y28C@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - FMN_bind,LRR_5 KKPNOBBG_04658 33035.JPJF01000054_gene1633 0.0 3225.0 COG2340@1|root,COG2340@2|Bacteria,1V1IM@1239|Firmicutes,24PYX@186801|Clostridia 186801|Clostridia N Cysteine-rich secretory protein family - - - - - - - - - - - - - KKPNOBBG_04659 33035.JPJF01000054_gene1634 0.0 2293.0 COG1657@1|root,COG3064@1|root,COG5492@1|root,COG1657@2|Bacteria,COG3064@2|Bacteria,COG5492@2|Bacteria,1UZVS@1239|Firmicutes,24DV2@186801|Clostridia,3Y094@572511|Blautia 186801|Clostridia IN Cysteine-rich secretory protein family - - - - - - - - - - - - Big_2,DUF4430,Prenyltrans,SLH,SQHop_cyclase_C KKPNOBBG_04660 33035.JPJF01000054_gene1635 1.33e-251 694.0 COG1657@1|root,COG1657@2|Bacteria,1VBUR@1239|Firmicutes,24F29@186801|Clostridia,3Y0B7@572511|Blautia 186801|Clostridia I Domain of unknown function (DUF4430) - - - - - - - - - - - - DUF4430 KKPNOBBG_04661 33035.JPJF01000054_gene1636 1.92e-244 672.0 COG0619@1|root,COG0619@2|Bacteria,1TSB5@1239|Firmicutes,24AN7@186801|Clostridia,3XZVA@572511|Blautia 186801|Clostridia P Cobalt transport protein - - - ko:K16785 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - CbiQ KKPNOBBG_04662 33035.JPJF01000054_gene1637 0.0 1085.0 COG1129@1|root,COG1129@2|Bacteria,1TQRP@1239|Firmicutes,24YCF@186801|Clostridia,3XYUV@572511|Blautia 186801|Clostridia G AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran,ECF-ribofla_trS,ECF_trnsprt KKPNOBBG_04663 33035.JPJF01000054_gene1638 1.09e-190 531.0 COG4720@1|root,COG4720@2|Bacteria,1V2DR@1239|Firmicutes,249XR@186801|Clostridia,3XZUX@572511|Blautia 186801|Clostridia S ECF-type riboflavin transporter, S component - - - ko:K16927 - M00582 - - ko00000,ko00002,ko02000 3.A.1.32 - - ECF-ribofla_trS,ECF_trnsprt KKPNOBBG_04664 33035.JPJF01000054_gene1639 5.29e-176 493.0 COG4509@1|root,COG4509@2|Bacteria,1TRWN@1239|Firmicutes,24JWH@186801|Clostridia,3Y2BS@572511|Blautia 186801|Clostridia S Sortase family srtB - 3.4.22.70 ko:K08600 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase KKPNOBBG_04665 33035.JPJF01000054_gene1640 7.88e-231 639.0 COG1865@1|root,COG1865@2|Bacteria,1TQHV@1239|Firmicutes,24AA4@186801|Clostridia,3Y0CC@572511|Blautia 186801|Clostridia S Adenosylcobinamide amidohydrolase cbiZ - - - - - - - - - - - CbiZ KKPNOBBG_04666 33035.JPJF01000054_gene1641 4.18e-120 345.0 COG5423@1|root,COG5423@2|Bacteria,1VBHK@1239|Firmicutes,24XGW@186801|Clostridia,3Y0MP@572511|Blautia 186801|Clostridia S Predicted metal-binding protein (DUF2284) - - - - - - - - - - - - DUF2284 KKPNOBBG_04667 1123075.AUDP01000024_gene1091 5.95e-132 387.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia,3WRCW@541000|Ruminococcaceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 KKPNOBBG_04668 1232453.BAIF02000033_gene2674 2.26e-179 513.0 COG0407@1|root,COG0407@2|Bacteria,1TSSK@1239|Firmicutes,24CHA@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04669 717605.Theco_0531 6.08e-21 102.0 COG1653@1|root,COG1653@2|Bacteria,1TS9Z@1239|Firmicutes,4HAYY@91061|Bacilli,26SK1@186822|Paenibacillaceae 91061|Bacilli G Arabinose-binding protein araN - - ko:K17234 ko02010,map02010 M00602 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.34 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04670 525904.Tter_2024 2.66e-60 201.0 COG1175@1|root,COG1175@2|Bacteria 2|Bacteria P transmembrane transport araP - - ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17316 ko02010,map02010 M00196,M00198,M00204,M00206,M00207,M00491,M00602,M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34 - - BPD_transp_1 KKPNOBBG_04671 457412.RSAG_02009 5.68e-61 201.0 COG0395@1|root,COG0395@2|Bacteria,1TSAB@1239|Firmicutes,249PI@186801|Clostridia,3WJ9E@541000|Ruminococcaceae 186801|Clostridia U ABC-type sugar transport system, permease component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04672 452637.Oter_2229 1.63e-179 554.0 COG2273@1|root,COG2273@2|Bacteria 2|Bacteria G xyloglucan:xyloglucosyl transferase activity - - - - - - - - - - - - BTAD,Glyco_hydro_16,Glyco_transf_25,Malectin,Ricin_B_lectin,Trans_reg_C,Trypsin,VCBS KKPNOBBG_04673 33035.JPJF01000054_gene1644 1.12e-304 830.0 COG3875@1|root,COG3875@2|Bacteria,1UYM4@1239|Firmicutes,24AR5@186801|Clostridia,3Y1D0@572511|Blautia 186801|Clostridia S Domain of unknown function (DUF2088) - - - - - - - - - - - - DUF2088 KKPNOBBG_04674 33035.JPJF01000054_gene1645 1.25e-239 659.0 COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,3Y2DN@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - 1.1.1.380 ko:K08322 ko00040,ko01100,map00040,map01100 - R10848 RC00085 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N KKPNOBBG_04675 33035.JPJF01000054_gene1646 5.13e-154 434.0 COG1802@1|root,COG1802@2|Bacteria,1V3SB@1239|Firmicutes,24EKV@186801|Clostridia 186801|Clostridia K transcriptional regulator (GntR - - - - - - - - - - - - FCD,GntR KKPNOBBG_04676 33035.JPJF01000054_gene1647 2.77e-273 754.0 COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia 186801|Clostridia EG Gluconate - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease KKPNOBBG_04677 33035.JPJF01000054_gene1648 1.12e-151 427.0 COG2186@1|root,COG2186@2|Bacteria,1V5UA@1239|Firmicutes,24BCM@186801|Clostridia,3Y01S@572511|Blautia 186801|Clostridia K FCD - - - - - - - - - - - - FCD,GntR KKPNOBBG_04678 33035.JPJF01000054_gene1649 0.0 1129.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,3Y0XG@572511|Blautia 186801|Clostridia EG Dehydratase family ilvD3 - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD KKPNOBBG_04679 33035.JPJF01000054_gene1650 6.12e-182 506.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,3Y15M@572511|Blautia 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase kduD - 1.1.1.127,1.1.1.69 ko:K00046,ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 KKPNOBBG_04681 33035.JPJF01000054_gene1651 7.17e-267 732.0 COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,3XZ7D@572511|Blautia 186801|Clostridia H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N KKPNOBBG_04682 33035.JPJF01000054_gene1652 1.6e-47 152.0 COG1476@1|root,COG1476@2|Bacteria,1VGJ5@1239|Firmicutes,24SZE@186801|Clostridia,3Y1YA@572511|Blautia 186801|Clostridia K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_19,HTH_3 KKPNOBBG_04683 33035.JPJF01000054_gene1653 0.0 869.0 COG1672@1|root,COG1672@2|Bacteria,1TR21@1239|Firmicutes,24ADD@186801|Clostridia,3Y0F7@572511|Blautia 186801|Clostridia S Archaea bacterial proteins of unknown function - - - ko:K06921 - - - - ko00000 - - - ATPase_2,DUF234 KKPNOBBG_04684 33035.JPJF01000054_gene1654 0.0 936.0 COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1TPVJ@1239|Firmicutes,2489X@186801|Clostridia,3XZ9P@572511|Blautia 186801|Clostridia T COG COG0642 Signal transduction histidine kinase yycG_1 - - - - - - - - - - - HAMP,HATPase_c,HisKA KKPNOBBG_04685 33035.JPJF01000054_gene1655 1.69e-161 452.0 COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,24843@186801|Clostridia,3XYGU@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_04686 33035.JPJF01000101_gene3271 4.19e-156 452.0 COG0681@1|root,COG0681@2|Bacteria,1VVMI@1239|Firmicutes,25114@186801|Clostridia,3XZH2@572511|Blautia 186801|Clostridia U Belongs to the peptidase S26 family - - - - - - - - - - - - - KKPNOBBG_04687 33035.JPJF01000101_gene3272 0.0 872.0 COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,3XZF0@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 apeA - - - - - - - - - - - Peptidase_M18 KKPNOBBG_04688 33035.JPJF01000101_gene3273 0.0 2020.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,3Y1CP@572511|Blautia 186801|Clostridia G Alpha mannosidase, middle domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_04689 33035.JPJF01000101_gene3274 1.14e-190 530.0 COG0395@1|root,COG0395@2|Bacteria,1TRGH@1239|Firmicutes,24C7R@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_04690 33035.JPJF01000101_gene3275 5.88e-199 552.0 COG1175@1|root,COG1175@2|Bacteria,1TSRA@1239|Firmicutes,24E4R@186801|Clostridia 186801|Clostridia P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K17238 ko02010,map02010 M00207,M00599 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.38 - - BPD_transp_1 KKPNOBBG_04691 33035.JPJF01000101_gene3276 0.0 896.0 COG2182@1|root,COG2182@2|Bacteria,1UI1M@1239|Firmicutes,25EAR@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_04692 33035.JPJF01000101_gene3277 6.76e-272 747.0 COG1653@1|root,COG1653@2|Bacteria,1V1YQ@1239|Firmicutes,24FS8@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 KKPNOBBG_04693 33035.JPJF01000101_gene3278 0.0 915.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT52@1239|Firmicutes,249A9@186801|Clostridia,3Y0A4@572511|Blautia 186801|Clostridia T COG COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04694 33035.JPJF01000101_gene3279 0.0 1106.0 COG2972@1|root,COG2972@2|Bacteria,1TW41@1239|Firmicutes,24AHF@186801|Clostridia 186801|Clostridia T signal transduction protein with a C-terminal ATPase domain - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_04695 33035.JPJF01000101_gene3280 6.86e-175 488.0 COG0454@1|root,COG0456@2|Bacteria,1V37I@1239|Firmicutes,24IZQ@186801|Clostridia,3XZHS@572511|Blautia 186801|Clostridia K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 KKPNOBBG_04696 33035.JPJF01000101_gene3281 5.11e-103 300.0 COG1695@1|root,COG1695@2|Bacteria,1V1R5@1239|Firmicutes,24FU3@186801|Clostridia,3XZWT@572511|Blautia 186801|Clostridia K Transcriptional regulator PadR-like family - - - - - - - - - - - - HTH_34,PadR,Vir_act_alpha_C KKPNOBBG_04697 33035.JPJF01000101_gene3282 2.14e-270 747.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,3XYXA@572511|Blautia 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_04698 33035.JPJF01000101_gene3283 8.67e-110 320.0 COG1309@1|root,COG1309@2|Bacteria,1UQPP@1239|Firmicutes,24UJ4@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_4,TetR_N KKPNOBBG_04699 33035.JPJF01000101_gene3284 1.93e-93 277.0 COG5660@1|root,COG5660@2|Bacteria,1VBBM@1239|Firmicutes,24NQV@186801|Clostridia 186801|Clostridia S Putative zinc-finger - - - - - - - - - - - - zf-HC2 KKPNOBBG_04700 33035.JPJF01000101_gene3286 0.0 976.0 COG2160@1|root,COG2160@2|Bacteria,1TPXC@1239|Firmicutes,24A08@186801|Clostridia,3XYUS@572511|Blautia 186801|Clostridia G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome KKPNOBBG_04701 33035.JPJF01000101_gene3287 3.59e-268 738.0 COG3629@1|root,COG3629@2|Bacteria,1UUVJ@1239|Firmicutes,25KD9@186801|Clostridia,3Y0XS@572511|Blautia 186801|Clostridia T Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD KKPNOBBG_04702 537007.BLAHAN_06385 6.93e-42 138.0 COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,3Y2CC@572511|Blautia 186801|Clostridia G PTS HPr component phosphorylation site ptsH - - ko:K11184,ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr KKPNOBBG_04703 537007.BLAHAN_06386 5.7e-154 441.0 COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,3XYJH@572511|Blautia 186801|Clostridia K May be required for sporulation whiA - - ko:K09762 - - - - ko00000 - - - HTH_WhiA,LAGLIDADG_WhiA,WhiA_N KKPNOBBG_04704 33035.JPJF01000078_gene23 4.9e-208 575.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,3XZM6@572511|Blautia 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 KKPNOBBG_04705 33035.JPJF01000078_gene24 9.55e-188 524.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,3XZDE@572511|Blautia 186801|Clostridia M UDP-N-acetylenolpyruvoylglucosamine reductase murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C KKPNOBBG_04706 33035.JPJF01000105_gene1796 1.21e-167 470.0 COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,3XZ1N@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 thiF - - ko:K22132 - - - - ko00000,ko03016 - - - ThiF KKPNOBBG_04707 33035.JPJF01000105_gene1797 1.75e-75 226.0 2ANER@1|root,315MJ@2|Bacteria,1V6SU@1239|Firmicutes,24JBZ@186801|Clostridia,3Y07D@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score spoVAE - - ko:K06407 - - - - ko00000 - - - SpoVAC_SpoVAEB KKPNOBBG_04708 33035.JPJF01000105_gene1798 5.99e-243 667.0 COG0332@1|root,COG0332@2|Bacteria,1TPDE@1239|Firmicutes,25EAS@186801|Clostridia,3XZKI@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 spoVAD - - ko:K06406 - - - - ko00000 - - - SpoVAD KKPNOBBG_04709 33035.JPJF01000105_gene1799 5.98e-108 311.0 2ANER@1|root,31DDD@2|Bacteria,1V46U@1239|Firmicutes,24JDI@186801|Clostridia,3Y02E@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score spoVAC - - ko:K06405 - - - - ko00000 - - - SpoVAC_SpoVAEB KKPNOBBG_04710 33035.JPJF01000105_gene1800 2.08e-132 376.0 COG2357@1|root,COG2357@2|Bacteria,1UZBZ@1239|Firmicutes,24FD2@186801|Clostridia,3XZXV@572511|Blautia 186801|Clostridia S Region found in RelA / SpoT proteins - - 2.7.6.5 ko:K07816 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - RelA_SpoT KKPNOBBG_04711 33035.JPJF01000105_gene1801 0.0 1516.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,248B9@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_04712 33035.JPJF01000004_gene2022 8.72e-163 455.0 COG3822@1|root,COG3822@2|Bacteria,1UXBF@1239|Firmicutes,249XW@186801|Clostridia,3Y111@572511|Blautia 186801|Clostridia S Pfam:DUF1498 - - 5.3.1.15 ko:K09988 ko00040,map00040 - R01898 RC00516 ko00000,ko00001,ko01000 - - - Lyx_isomer KKPNOBBG_04713 33035.JPJF01000004_gene2021 0.0 951.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,24AWQ@186801|Clostridia,3Y0N7@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF3502) - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - DUF3502,SBP_bac_1,SBP_bac_8 KKPNOBBG_04714 33035.JPJF01000004_gene2020 7.25e-205 569.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia,3Y17J@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_04715 33035.JPJF01000004_gene2019 1.37e-220 609.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,3Y198@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_04717 742765.HMPREF9457_00650 2.38e-50 159.0 2AD7W@1|root,312WU@2|Bacteria,1V7M4@1239|Firmicutes,24M52@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_04718 397288.C806_04703 1.52e-177 510.0 COG0534@1|root,COG0534@2|Bacteria,1TQWU@1239|Firmicutes,24BZG@186801|Clostridia,27JMH@186928|unclassified Lachnospiraceae 186801|Clostridia V MatE - - - - - - - - - - - - MatE KKPNOBBG_04719 457415.HMPREF1006_01658 1.9e-36 129.0 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - MarR,MarR_2 KKPNOBBG_04720 397290.C810_01652 1.36e-151 435.0 2DBGE@1|root,2Z949@2|Bacteria,1TT46@1239|Firmicutes,248XE@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_04722 411459.RUMOBE_03478 8.39e-59 182.0 28NQR@1|root,2ZBQ4@2|Bacteria,1V3BU@1239|Firmicutes,24FVP@186801|Clostridia,3Y035@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04723 411459.RUMOBE_03479 9.51e-47 150.0 2DAN3@1|root,32TVS@2|Bacteria,1VABD@1239|Firmicutes,2598P@186801|Clostridia,3Y0GU@572511|Blautia 186801|Clostridia L Helix-turn-helix domain - - - - - - - - - - - - HTH_17 KKPNOBBG_04724 500632.CLONEX_02356 3.38e-133 379.0 COG1396@1|root,COG1396@2|Bacteria,1TRKK@1239|Firmicutes,24C0F@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - HTH_3 KKPNOBBG_04725 411460.RUMTOR_00946 2.17e-302 825.0 COG0582@1|root,COG0582@2|Bacteria,1TSQW@1239|Firmicutes,249T6@186801|Clostridia,3XZQW@572511|Blautia 186801|Clostridia L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase KKPNOBBG_04726 33035.JPJF01000004_gene2018 2.99e-130 374.0 COG4942@1|root,COG4942@2|Bacteria 2|Bacteria D peptidase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - PDDEXK_2 KKPNOBBG_04727 33035.JPJF01000004_gene2016 0.0 1005.0 2CK7V@1|root,2Z9WF@2|Bacteria,1TRYE@1239|Firmicutes,24E2Q@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04728 33035.JPJF01000004_gene2015 3.85e-269 744.0 COG0260@1|root,COG0260@2|Bacteria,1TPJZ@1239|Firmicutes,248KF@186801|Clostridia,3Y1U6@572511|Blautia 186801|Clostridia E Cytosol aminopeptidase family, catalytic domain pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N KKPNOBBG_04729 33035.JPJF01000004_gene2014 0.0 1947.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia 186801|Clostridia G Glycosyl hydrolases family 38 C-terminal domain - - - - - - - - - - - - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_04730 33035.JPJF01000004_gene2013 3.9e-303 829.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia 186801|Clostridia G family 4 - - 3.2.1.86 ko:K01222 ko00010,ko00500,map00010,map00500 - R00839,R05133,R05134 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GT4 - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_04731 33035.JPJF01000004_gene2012 1.05e-201 561.0 COG0524@1|root,COG0524@2|Bacteria,1V123@1239|Firmicutes,24DMU@186801|Clostridia 186801|Clostridia G Kinase, PfkB family - - - - - - - - - - - - PfkB KKPNOBBG_04732 33035.JPJF01000004_gene2011 9.03e-203 563.0 COG0395@1|root,COG0395@2|Bacteria,1UXJB@1239|Firmicutes,25M50@186801|Clostridia,3Y1NB@572511|Blautia 186801|Clostridia G ABC-type sugar transport system, permease component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - - KKPNOBBG_04733 33035.JPJF01000004_gene2010 0.0 1129.0 COG1653@1|root,COG1653@2|Bacteria,1TTUX@1239|Firmicutes,25INP@186801|Clostridia,3Y22U@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_04734 33035.JPJF01000004_gene2009 2.74e-213 590.0 COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,3Y1CA@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04735 33035.JPJF01000004_gene2008 1.17e-168 473.0 COG3568@1|root,COG3568@2|Bacteria,1V8ES@1239|Firmicutes,24CS2@186801|Clostridia 186801|Clostridia L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos KKPNOBBG_04736 33035.JPJF01000004_gene2007 9.25e-217 598.0 COG0613@1|root,COG0613@2|Bacteria,1V6HN@1239|Firmicutes,24DQ6@186801|Clostridia 186801|Clostridia S DNA polymerase alpha chain like domain - - - - - - - - - - - - - KKPNOBBG_04737 33035.JPJF01000004_gene2006 9.44e-99 287.0 2BBZP@1|root,325I9@2|Bacteria,1V8YY@1239|Firmicutes,24M01@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04738 33035.JPJF01000004_gene2005 1.95e-202 563.0 COG0613@1|root,COG0613@2|Bacteria,1V2U3@1239|Firmicutes,24CV5@186801|Clostridia 186801|Clostridia S DNA polymerase alpha chain like domain - - - - - - - - - - - - PHP KKPNOBBG_04739 33035.JPJF01000004_gene2004 0.0 1066.0 COG2972@1|root,COG2972@2|Bacteria,1UZD9@1239|Firmicutes,248V9@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04740 33035.JPJF01000004_gene2003 0.0 924.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TV2J@1239|Firmicutes,249HW@186801|Clostridia,3Y1MG@572511|Blautia 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04741 33035.JPJF01000004_gene2002 3.49e-245 679.0 COG2271@1|root,COG2271@2|Bacteria,1TS33@1239|Firmicutes,248WJ@186801|Clostridia 186801|Clostridia G transporter glpT - - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - - MFS_1 KKPNOBBG_04742 33035.JPJF01000004_gene2001 0.0 878.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3XZ1E@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04743 33035.JPJF01000004_gene2000 0.0 995.0 COG2972@1|root,COG2972@2|Bacteria,1TR02@1239|Firmicutes,249P5@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase KKPNOBBG_04744 1123075.AUDP01000016_gene3428 5.08e-58 197.0 COG0407@1|root,COG0407@2|Bacteria,1TNZU@1239|Firmicutes,24A05@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04745 1123075.AUDP01000003_gene557 4.51e-143 416.0 COG0407@1|root,COG0407@2|Bacteria,1V5ND@1239|Firmicutes,24IEP@186801|Clostridia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_04746 33035.JPJF01000009_gene1481 6.64e-72 241.0 COG3069@1|root,COG3069@2|Bacteria,1U0AJ@1239|Firmicutes,24DKS@186801|Clostridia 186801|Clostridia C C4-dicarboxylate anaerobic carrier - - - ko:K03326 - - - - ko00000,ko02000 2.A.61.1 - - DcuC KKPNOBBG_04747 1123075.AUDP01000003_gene554 9.6e-50 186.0 COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia,3WM6D@541000|Ruminococcaceae 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30,PucR KKPNOBBG_04748 1499680.CCFE01000011_gene711 6.24e-57 200.0 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4ITPR@91061|Bacilli,1ZSG6@1386|Bacillus 91061|Bacilli P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS KKPNOBBG_04749 33035.JPJF01000004_gene1999 9.99e-137 390.0 2CG95@1|root,2ZMM2@2|Bacteria,1V1VY@1239|Firmicutes,24G6J@186801|Clostridia 186801|Clostridia S Protein of unknown function, DUF624 - - - - - - - - - - - - DUF624 KKPNOBBG_04750 33035.JPJF01000004_gene1998 0.0 2022.0 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia 186801|Clostridia G Glycosyl hydrolases family 38 C-terminal domain - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C KKPNOBBG_04751 33035.JPJF01000004_gene1997 3.64e-308 840.0 COG3538@1|root,COG3538@2|Bacteria,1TRJI@1239|Firmicutes,248YF@186801|Clostridia,3Y17E@572511|Blautia 186801|Clostridia S Metal-independent alpha-mannosidase (GH125) - - - ko:K09704 - - - - ko00000 - - - Glyco_hydro_125 KKPNOBBG_04752 33035.JPJF01000004_gene1996 0.0 979.0 COG1672@1|root,COG1672@2|Bacteria,1TQQ5@1239|Firmicutes,24918@186801|Clostridia,3Y11F@572511|Blautia 186801|Clostridia M non supervised orthologous group - - - - - - - - - - - - AAA-ATPase_like,PDDEXK_9 KKPNOBBG_04753 33035.JPJF01000004_gene1995 7.62e-173 485.0 COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia 186801|Clostridia L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS KKPNOBBG_04754 33035.JPJF01000004_gene1994 9.73e-55 171.0 COG3708@1|root,COG3708@2|Bacteria,1VFMZ@1239|Firmicutes,24RKD@186801|Clostridia 186801|Clostridia K Putative zinc ribbon domain - - - - - - - - - - - - Cass2,Zn_ribbon_2 KKPNOBBG_04755 33035.JPJF01000004_gene1993 4.16e-175 493.0 COG2378@1|root,COG2378@2|Bacteria,1TS78@1239|Firmicutes,25C7I@186801|Clostridia 186801|Clostridia K HTH domain - - - - - - - - - - - - HTH_11,WYL,Zn_ribbon_2 KKPNOBBG_04757 33035.JPJF01000004_gene1992 7.45e-82 243.0 2AF43@1|root,3152T@2|Bacteria,1VFMI@1239|Firmicutes,24RBI@186801|Clostridia,3Y0C4@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K06404 - - - - ko00000 - - - SpoVAB KKPNOBBG_04758 33035.JPJF01000004_gene1991 1.08e-135 385.0 28PNE@1|root,2ZCB6@2|Bacteria,1V214@1239|Firmicutes,24DN2@186801|Clostridia,3XZTN@572511|Blautia 186801|Clostridia S Psort location spoVAA - - ko:K06403 - - - - ko00000 - - - SporV_AA KKPNOBBG_04759 33035.JPJF01000004_gene1990 1.17e-156 441.0 COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia,3XZEX@572511|Blautia 186801|Clostridia K COG COG1191 DNA-directed RNA polymerase specialized sigma subunit sigF - - ko:K03091 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 KKPNOBBG_04760 33035.JPJF01000004_gene1989 5.78e-97 282.0 COG2172@1|root,COG2172@2|Bacteria,1V6V2@1239|Firmicutes,24JPT@186801|Clostridia,3Y0A1@572511|Blautia 186801|Clostridia H Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition spoIIAB - 2.7.11.1 ko:K06379 - - - - ko00000,ko01000 - - - HATPase_c_2 KKPNOBBG_04761 33035.JPJF01000004_gene1988 1.6e-65 199.0 COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,3Y0KP@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 8.87 spoIIAA - - ko:K06378 - - - - ko00000 - - - STAS KKPNOBBG_04762 33035.JPJF01000004_gene1987 2.64e-290 803.0 COG3063@1|root,COG3063@2|Bacteria,1UY48@1239|Firmicutes,24AGF@186801|Clostridia,3XYR7@572511|Blautia 186801|Clostridia NU Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 KKPNOBBG_04763 33035.JPJF01000004_gene1986 2.55e-28 101.0 2EGDA@1|root,33A54@2|Bacteria,1VKC8@1239|Firmicutes,258G8@186801|Clostridia,3Y0SU@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04764 33035.JPJF01000004_gene1985 2.83e-299 818.0 COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3XZC1@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M KKPNOBBG_04765 33035.JPJF01000004_gene1984 0.0 1328.0 COG1368@1|root,COG1368@2|Bacteria,1TQYQ@1239|Firmicutes,25CNS@186801|Clostridia,3XYIH@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Sulfatase KKPNOBBG_04766 33035.JPJF01000004_gene1983 0.0 1712.0 COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3XYWB@572511|Blautia 186801|Clostridia J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 KKPNOBBG_04767 33035.JPJF01000015_gene4979 2.41e-315 884.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XZXF@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_04768 1226325.HMPREF1548_02391 2.59e-156 461.0 COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,36FZX@31979|Clostridiaceae 186801|Clostridia C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FMN_bind KKPNOBBG_04769 1298593.TOL_1200 3.42e-71 230.0 COG0657@1|root,COG0657@2|Bacteria,1R4AU@1224|Proteobacteria,1RQMN@1236|Gammaproteobacteria,1XR8Q@135619|Oceanospirillales 135619|Oceanospirillales I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 KKPNOBBG_04770 699246.HMPREF0868_0312 1.05e-234 681.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_04771 545696.HOLDEFILI_00713 5.41e-59 196.0 COG0327@1|root,COG0327@2|Bacteria,1URBZ@1239|Firmicutes,3VPFA@526524|Erysipelotrichia 526524|Erysipelotrichia S NIF3 (NGG1p interacting factor 3) - - - - - - - - - - - - NIF3 KKPNOBBG_04772 888064.HMPREF9088_1772 9.38e-87 266.0 COG0627@1|root,COG0627@2|Bacteria,1TPA9@1239|Firmicutes,4HD64@91061|Bacilli,4B548@81852|Enterococcaceae 91061|Bacilli S Putative esterase - - - - - - - - - - - - Esterase KKPNOBBG_04773 269798.CHU_0721 2.31e-18 93.6 COG2755@1|root,COG2755@2|Bacteria,4NFVN@976|Bacteroidetes,47VUY@768503|Cytophagia 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL_2 KKPNOBBG_04774 33035.JPJF01000008_gene1204 2.34e-140 404.0 COG0395@1|root,COG0395@2|Bacteria,1UXJC@1239|Firmicutes,25M51@186801|Clostridia,3Y1N9@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04775 1280671.AUJH01000023_gene3629 8.04e-149 427.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia,4BX4G@830|Butyrivibrio 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_04776 33035.JPJF01000008_gene1202 8.21e-165 483.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,249PT@186801|Clostridia 186801|Clostridia G Domain of unknown function (DUF3502) - - - - - - - - - - - - DUF3502,SBP_bac_1,SBP_bac_8 KKPNOBBG_04777 33035.JPJF01000008_gene1201 4.23e-133 404.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,24FD5@186801|Clostridia 186801|Clostridia T Psort location Cytoplasmic, score - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_04778 33035.JPJF01000008_gene1200 8e-139 421.0 COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,24CTB@186801|Clostridia 186801|Clostridia T K07718 two-component system, sensor histidine kinase YesM - - - - - - - - - - - - His_kinase KKPNOBBG_04779 33035.JPJF01000004_gene1974 1.85e-35 121.0 2EIJI@1|root,33CAV@2|Bacteria,1VK5E@1239|Firmicutes,24MMQ@186801|Clostridia,3Y0TE@572511|Blautia 186801|Clostridia S COG NOG17864 non supervised orthologous group - - - - - - - - - - - - SASP KKPNOBBG_04780 33035.JPJF01000004_gene1973 1.87e-113 336.0 COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia 186801|Clostridia V PFAM SCP-like extracellular safA - - - - - - - - - - - CAP,LysM KKPNOBBG_04781 1232449.BAHV02000007_gene807 4.73e-238 665.0 COG0534@1|root,COG0534@2|Bacteria,1VS1B@1239|Firmicutes 1239|Firmicutes V MatE - - - - - - - - - - - - MatE KKPNOBBG_04782 1232449.BAHV02000007_gene806 2.82e-76 235.0 COG1309@1|root,COG1309@2|Bacteria,1V6GJ@1239|Firmicutes,24J0S@186801|Clostridia,269CC@186813|unclassified Clostridiales 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_04783 33035.JPJF01000004_gene1972 4.44e-28 101.0 COG1983@1|root,COG1983@2|Bacteria,1TUCF@1239|Firmicutes,25PAV@186801|Clostridia,3Y0SN@572511|Blautia 186801|Clostridia KT PspC domain - - - - - - - - - - - - PspC KKPNOBBG_04784 33035.JPJF01000004_gene1971 1.87e-123 361.0 2E3J1@1|root,32YHG@2|Bacteria,1VF3S@1239|Firmicutes,25E89@186801|Clostridia,3Y0KC@572511|Blautia 186801|Clostridia S Putative adhesin - - - - - - - - - - - - DUF4097 KKPNOBBG_04785 33035.JPJF01000004_gene1970 1.82e-103 309.0 COG4709@1|root,COG4709@2|Bacteria,1VETQ@1239|Firmicutes,24G3G@186801|Clostridia,3Y0B4@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DUF1700 KKPNOBBG_04786 33035.JPJF01000004_gene1969 2.83e-69 209.0 COG1695@1|root,COG1695@2|Bacteria,1VACN@1239|Firmicutes,24MRF@186801|Clostridia,3Y09J@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score 8.87 - - - ko:K10947 - - - - ko00000,ko03000 - - - PadR KKPNOBBG_04787 33035.JPJF01000004_gene1968 1.67e-119 343.0 2ADW4@1|root,313N4@2|Bacteria,1V790@1239|Firmicutes 1239|Firmicutes S Protein of unknown function (DUF4230) - - - - - - - - - - - - DUF4230 KKPNOBBG_04788 33035.JPJF01000004_gene1967 0.0 1082.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3XYGZ@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04789 33035.JPJF01000004_gene1966 0.0 1032.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,3XYTP@572511|Blautia 186801|Clostridia V COG COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04790 658655.HMPREF0988_02860 1.94e-51 194.0 COG2972@1|root,COG2972@2|Bacteria,1UW47@1239|Firmicutes,25KQI@186801|Clostridia,27RWA@186928|unclassified Lachnospiraceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04792 697281.Mahau_0700 9.24e-172 489.0 COG4030@1|root,COG4030@2|Bacteria,1TRZY@1239|Firmicutes,249GP@186801|Clostridia,42HQP@68295|Thermoanaerobacterales 186801|Clostridia S Protein of unknown function (DUF2961) - - - - - - - - - - - - DUF2961 KKPNOBBG_04793 1280680.AUJU01000008_gene189 3.06e-130 381.0 COG4608@1|root,COG4608@2|Bacteria,1UX9A@1239|Firmicutes,24Z8K@186801|Clostridia,4BYN2@830|Butyrivibrio 186801|Clostridia E Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY KKPNOBBG_04794 1280673.AUJJ01000001_gene2217 3.84e-133 388.0 COG0444@1|root,COG0444@2|Bacteria,1UX99@1239|Firmicutes,25KBT@186801|Clostridia,4BWQT@830|Butyrivibrio 186801|Clostridia EP Oligopeptide/dipeptide transporter, C-terminal region - - - - - - - - - - - - ABC_tran,oligo_HPY KKPNOBBG_04795 1122132.AQYH01000004_gene1674 9.74e-99 298.0 COG1173@1|root,COG1173@2|Bacteria,1R4DJ@1224|Proteobacteria,2U44U@28211|Alphaproteobacteria,4B9Q2@82115|Rhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_04796 1122132.AQYH01000004_gene1675 4.08e-127 373.0 COG0601@1|root,COG0601@2|Bacteria,1QDMV@1224|Proteobacteria,2TTGN@28211|Alphaproteobacteria,4B6XV@82115|Rhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_04797 1122132.AQYH01000004_gene1671 7.33e-227 651.0 COG0747@1|root,COG0747@2|Bacteria,1R49R@1224|Proteobacteria,2U1IU@28211|Alphaproteobacteria,4BBXQ@82115|Rhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_04798 428125.CLOLEP_00989 1.56e-28 126.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZCE@1239|Firmicutes,24C9H@186801|Clostridia 186801|Clostridia T COG COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04799 33035.JPJF01000004_gene1965 3.82e-310 848.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3XZM1@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp KKPNOBBG_04800 33035.JPJF01000004_gene1964 0.0 2092.0 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,3XYPU@572511|Blautia 186801|Clostridia L ATP-dependent helicase nuclease subunit A addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C KKPNOBBG_04801 33035.JPJF01000004_gene1963 0.0 2055.0 COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,3XYMT@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - Exonuc_V_gamma,PDDEXK_1,UvrD_C KKPNOBBG_04802 33035.JPJF01000004_gene1962 1.6e-182 509.0 COG0561@1|root,COG0561@2|Bacteria,1TR16@1239|Firmicutes,248MW@186801|Clostridia,3XZU4@572511|Blautia 186801|Clostridia S Sucrose-6F-phosphate phosphohydrolase - - - - - - - - - - - - Hydrolase_3 KKPNOBBG_04803 428125.CLOLEP_00806 1.39e-77 261.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3WIY2@541000|Ruminococcaceae 186801|Clostridia K response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04804 428125.CLOLEP_00807 1.72e-143 436.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_04805 428125.CLOLEP_00811 5.95e-108 321.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249S6@186801|Clostridia,3WP49@541000|Ruminococcaceae 186801|Clostridia P COG COG0395 ABC-type sugar transport system, permease component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04806 428125.CLOLEP_00810 3.73e-107 320.0 COG1175@1|root,COG1175@2|Bacteria,1TRI2@1239|Firmicutes,24DZ7@186801|Clostridia,3WP6P@541000|Ruminococcaceae 186801|Clostridia P COG COG1175 ABC-type sugar transport systems, permease components - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04807 428125.CLOLEP_00809 2.72e-122 371.0 COG1653@1|root,COG1653@2|Bacteria,1TX9U@1239|Firmicutes,25B7M@186801|Clostridia,3WPR7@541000|Ruminococcaceae 186801|Clostridia P COG COG1653 ABC-type sugar transport system, periplasmic component - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_04808 428125.CLOLEP_01107 5.42e-47 181.0 COG3534@1|root,COG3534@2|Bacteria,1TRY9@1239|Firmicutes,2497J@186801|Clostridia,3WHPB@541000|Ruminococcaceae 186801|Clostridia G Alpha-L-arabinofuranosidase domain protein - - - - - - - - - - - - Alpha-L-AF_C,Glyco_hydro_79n KKPNOBBG_04809 33035.JPJF01000004_gene1961 1.78e-81 243.0 COG3976@1|root,COG3976@2|Bacteria,1V72R@1239|Firmicutes,24JFD@186801|Clostridia,3Y05F@572511|Blautia 186801|Clostridia S FMN-binding domain protein - - - - - - - - - - - - - KKPNOBBG_04810 33035.JPJF01000004_gene1960 3.39e-240 665.0 COG1388@1|root,COG3757@1|root,COG1388@2|Bacteria,COG3757@2|Bacteria,1V484@1239|Firmicutes,24A8T@186801|Clostridia,3Y2DQ@572511|Blautia 186801|Clostridia M Lysin motif lyc2 GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.17 ko:K01185,ko:K07273 - - - - ko00000,ko01000 - - - CW_binding_1,Glyco_hydro_25,LysM,PG_binding_1,SH3_3 KKPNOBBG_04811 1122918.KB907282_gene4967 1.29e-103 310.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,4HASN@91061|Bacilli,26SH6@186822|Paenibacillaceae 91061|Bacilli G COG0395 ABC-type sugar transport system, permease component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04812 858215.Thexy_1726 4.88e-109 325.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,42FIE@68295|Thermoanaerobacterales 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04813 1122918.KB907282_gene4969 5.26e-88 281.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,4HB0G@91061|Bacilli,26UZ8@186822|Paenibacillaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04814 1195236.CTER_1950 1.56e-75 255.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3WIY2@541000|Ruminococcaceae 186801|Clostridia K response regulator receiver - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_04815 398512.JQKC01000017_gene3034 3.23e-78 266.0 COG2972@1|root,COG2972@2|Bacteria,1TT1G@1239|Firmicutes,2495G@186801|Clostridia,3WIVH@541000|Ruminococcaceae 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,His_kinase,dCache_1 KKPNOBBG_04816 1105031.HMPREF1141_3560 2.22e-75 236.0 COG2159@1|root,COG2159@2|Bacteria,1V72X@1239|Firmicutes,24FW1@186801|Clostridia,36Q1E@31979|Clostridiaceae 186801|Clostridia S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 KKPNOBBG_04817 457421.CBFG_03788 1.54e-283 788.0 COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,2684H@186813|unclassified Clostridiales 186801|Clostridia EG Dehydratase family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD KKPNOBBG_04818 324057.Pjdr2_0297 1.08e-256 746.0 COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,4HDFB@91061|Bacilli,26VW6@186822|Paenibacillaceae 91061|Bacilli G Bacterial alpha-L-rhamnosidase C-terminal domain - - - - - - - - - - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N KKPNOBBG_04819 1120950.KB892794_gene2330 9.85e-35 136.0 COG1063@1|root,COG1063@2|Bacteria,2GKU2@201174|Actinobacteria,4DSG4@85009|Propionibacteriales 201174|Actinobacteria E Dehydrogenase - - - - - - - - - - - - ADH_zinc_N KKPNOBBG_04820 742740.HMPREF9474_00636 7.76e-140 407.0 COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,21ZD2@1506553|Lachnoclostridium 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_04821 33035.JPJF01000004_gene1959 3.14e-194 540.0 COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia,3Y0BN@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04822 33035.JPJF01000004_gene1958 5.02e-223 617.0 COG1175@1|root,COG1175@2|Bacteria,1TP1Q@1239|Firmicutes,24ADV@186801|Clostridia,3XZ1D@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04823 33035.JPJF01000004_gene1957 1.91e-314 857.0 COG1653@1|root,COG1653@2|Bacteria,1TQHT@1239|Firmicutes,249J6@186801|Clostridia,3XZHY@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_8 KKPNOBBG_04824 33035.JPJF01000004_gene1956 5.1e-223 618.0 COG1609@1|root,COG1609@2|Bacteria,1TS5M@1239|Firmicutes,24AWP@186801|Clostridia,3Y018@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_04825 33035.JPJF01000004_gene1955 0.0 1307.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3XYP0@572511|Blautia 186801|Clostridia G Galactose mutarotase-like - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF5110,Gal_mutarotas_2,Glyco_hydro_31 KKPNOBBG_04827 33035.JPJF01000004_gene1953 1.39e-211 587.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,248MV@186801|Clostridia,3Y29U@572511|Blautia 186801|Clostridia S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_04828 33035.JPJF01000004_gene1952 3.21e-244 673.0 COG1063@1|root,COG1063@2|Bacteria,1TPIW@1239|Firmicutes,24AY7@186801|Clostridia,3XYJG@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score - - - ko:K18369 ko00640,map00640 - R10703 RC00545 ko00000,ko00001,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N,ADH_zinc_N_2 KKPNOBBG_04829 33035.JPJF01000004_gene1951 0.0 1248.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,3XZ2F@572511|Blautia 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase KKPNOBBG_04830 33035.JPJF01000004_gene1950 2.5e-200 556.0 COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,3XYXT@572511|Blautia 186801|Clostridia O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 KKPNOBBG_04831 33035.JPJF01000004_gene1949 3.62e-168 471.0 COG4976@1|root,COG4976@2|Bacteria,1UHZM@1239|Firmicutes,24A6U@186801|Clostridia,3XYHA@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Methyltransf_25 KKPNOBBG_04832 411459.RUMOBE_02166 6.49e-77 238.0 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity - - - - - - - - - - - - Abhydrolase_3,F5_F8_type_C,Peptidase_S9 KKPNOBBG_04833 33035.JPJF01000004_gene1948 0.0 1333.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3XZXF@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C KKPNOBBG_04834 33035.JPJF01000004_gene1947 0.0 926.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,24FD5@186801|Clostridia,3Y1DI@572511|Blautia 186801|Clostridia KT helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_04835 33035.JPJF01000004_gene1946 0.0 1043.0 COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,257VB@186801|Clostridia,3Y13A@572511|Blautia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04836 33035.JPJF01000004_gene1945 2.5e-203 564.0 COG0395@1|root,COG0395@2|Bacteria,1TP1G@1239|Firmicutes,247T2@186801|Clostridia 186801|Clostridia P PFAM binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04837 33035.JPJF01000004_gene1944 4.26e-201 558.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,24923@186801|Clostridia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K17319 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_04838 33035.JPJF01000004_gene1943 0.0 981.0 COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,25NJ2@186801|Clostridia,3Y1EP@572511|Blautia 186801|Clostridia G Domain of unknown function (DUF3502) - - - - - - - - - - - - DUF3502 KKPNOBBG_04839 33035.JPJF01000032_gene2144 1.34e-31 110.0 2EG1V@1|root,339TV@2|Bacteria,1VKAZ@1239|Firmicutes,24UGV@186801|Clostridia,3Y0SX@572511|Blautia 186801|Clostridia S COG NOG17973 non supervised orthologous group - - - - - - - - - - - - DUF4250 KKPNOBBG_04840 33035.JPJF01000032_gene2145 0.0 1632.0 COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3XZ90@572511|Blautia 186801|Clostridia O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N KKPNOBBG_04841 500632.CLONEX_03692 1.79e-227 634.0 COG0582@1|root,COG0582@2|Bacteria,1VRCP@1239|Firmicutes,24BDU@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Integrase_DNA,Phage_int_SAM_3,Phage_integrase KKPNOBBG_04842 500632.CLONEX_03693 2.97e-29 105.0 2EQGP@1|root,33I2P@2|Bacteria,1VKY1@1239|Firmicutes,24SQ3@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04844 1298920.KI911353_gene971 7.63e-311 869.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,21YQ6@1506553|Lachnoclostridium 186801|Clostridia G Galactose mutarotase-like - - - - - - - - - - - - CBM_35,Gal_mutarotas_2,Glyco_hydro_31 KKPNOBBG_04845 1536773.R70331_15735 2.78e-182 523.0 COG5434@1|root,COG5434@2|Bacteria,1TQQW@1239|Firmicutes,4HDV0@91061|Bacilli,26VXQ@186822|Paenibacillaceae 91061|Bacilli M Glycosyl hydrolases family 28 - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 KKPNOBBG_04846 1034769.KB910518_gene726 1.22e-190 593.0 28HPB@1|root,2Z7XC@2|Bacteria,1VMJ8@1239|Firmicutes,4HWJW@91061|Bacilli,26TCT@186822|Paenibacillaceae 91061|Bacilli S PFAM Heparinase II III family protein - - - - - - - - - - - - Alginate_lyase,Hepar_II_III KKPNOBBG_04847 1122925.KB895381_gene3880 6.87e-118 365.0 COG1653@1|root,COG1653@2|Bacteria,1V4UQ@1239|Firmicutes,4HTKS@91061|Bacilli,26VWZ@186822|Paenibacillaceae 91061|Bacilli G Domain of unknown function (DUF3502) - - - - - - - - - - - - DUF3502,SBP_bac_1 KKPNOBBG_04848 1122925.KB895381_gene3879 7.2e-116 342.0 COG0395@1|root,COG0395@2|Bacteria,1VR46@1239|Firmicutes,4IQN7@91061|Bacilli,26UMV@186822|Paenibacillaceae 91061|Bacilli G Binding-protein-dependent transport system inner membrane component - - - ko:K17320 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - BPD_transp_1 KKPNOBBG_04849 1122925.KB895381_gene3878 2.63e-115 342.0 COG4209@1|root,COG4209@2|Bacteria,1TQFY@1239|Firmicutes,4HBB0@91061|Bacilli,26QHF@186822|Paenibacillaceae 91061|Bacilli G binding-protein-dependent transport systems inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04850 44251.PDUR_16350 7e-16 90.1 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TT52@1239|Firmicutes,4IPNV@91061|Bacilli,27615@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,Response_reg KKPNOBBG_04851 478749.BRYFOR_08735 2.74e-64 210.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ramA - - - - - - - - - - - CN_hydrolase KKPNOBBG_04852 478749.BRYFOR_08747 5.39e-213 595.0 COG1331@1|root,COG1331@2|Bacteria,1TQ83@1239|Firmicutes,24ZNJ@186801|Clostridia 186801|Clostridia O Unsaturated glucuronyl hydrolase - - 3.2.1.180 ko:K18581 - - R10867 RC00049,RC02427 ko00000,ko01000 - GH88 - Glyco_hydro_88 KKPNOBBG_04853 478749.BRYFOR_08747 5.5e-209 585.0 COG1331@1|root,COG1331@2|Bacteria,1TQ83@1239|Firmicutes,24ZNJ@186801|Clostridia 186801|Clostridia O Unsaturated glucuronyl hydrolase - - 3.2.1.180 ko:K18581 - - R10867 RC00049,RC02427 ko00000,ko01000 - GH88 - Glyco_hydro_88 KKPNOBBG_04854 1449050.JNLE01000003_gene3345 8.7e-73 230.0 COG2207@1|root,COG2207@2|Bacteria,1TR4U@1239|Firmicutes,24JVF@186801|Clostridia,36IMW@31979|Clostridiaceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - ko:K02099 - - - - ko00000,ko03000 - - - HTH_18,HTH_AraC KKPNOBBG_04855 1226325.HMPREF1548_02368 7.42e-223 623.0 COG2942@1|root,COG2942@2|Bacteria,1UQC2@1239|Firmicutes,24D2T@186801|Clostridia 186801|Clostridia G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) - - - - - - - - - - - - GlcNAc_2-epim KKPNOBBG_04856 478749.BRYFOR_09572 0.0 1219.0 COG1874@1|root,COG1874@2|Bacteria,1UZRC@1239|Firmicutes,24EDS@186801|Clostridia 186801|Clostridia G Beta-galactosidase - - - - - - - - - - - - - KKPNOBBG_04857 768486.EHR_14305 1.85e-13 85.5 COG1196@1|root,COG1409@1|root,COG5492@1|root,COG1196@2|Bacteria,COG1409@2|Bacteria,COG5492@2|Bacteria,1TQ2K@1239|Firmicutes,4HBG8@91061|Bacilli,4B1XV@81852|Enterococcaceae 91061|Bacilli N Polysaccharide lyase family hylB GO:0005575,GO:0005576 4.2.2.1 ko:K01727 - - - - ko00000,ko01000 - PL8 - Big_2,F5_F8_type_C,FIVAR,Gram_pos_anchor,Lyase_8,Lyase_8_C,Lyase_8_N,SLH,YSIRK_signal KKPNOBBG_04858 1298920.KI911353_gene975 2.25e-119 350.0 COG0395@1|root,COG0395@2|Bacteria,1TR45@1239|Firmicutes,24A48@186801|Clostridia,220J6@1506553|Lachnoclostridium 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04859 1298920.KI911353_gene974 8.05e-114 338.0 COG1175@1|root,COG1175@2|Bacteria,1TRA3@1239|Firmicutes,24BD8@186801|Clostridia,21ZMA@1506553|Lachnoclostridium 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04860 1536775.H70737_17780 3.14e-105 327.0 COG1653@1|root,COG1653@2|Bacteria,1TPBS@1239|Firmicutes,4IPRZ@91061|Bacilli,26UKJ@186822|Paenibacillaceae 91061|Bacilli G ABC transporter substrate-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04861 1298920.KI911353_gene977 1.22e-132 401.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UZHC@1239|Firmicutes,24Z6S@186801|Clostridia,222S8@1506553|Lachnoclostridium 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_04862 1298920.KI911353_gene976 2.21e-174 515.0 COG2972@1|root,COG2972@2|Bacteria,1UZXN@1239|Firmicutes,25KS2@186801|Clostridia,2222V@1506553|Lachnoclostridium 186801|Clostridia T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,His_kinase KKPNOBBG_04863 478749.BRYFOR_08735 9.43e-91 277.0 COG0388@1|root,COG0388@2|Bacteria 2|Bacteria S hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ramA - - - - - - - - - - - CN_hydrolase KKPNOBBG_04865 1341157.RF007C_01015 1.95e-26 105.0 COG0681@1|root,COG0681@2|Bacteria,1V2HE@1239|Firmicutes,24R2U@186801|Clostridia,3WKN5@541000|Ruminococcaceae 186801|Clostridia U Peptidase S24-like - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 KKPNOBBG_04868 1341157.RF007C_01010 3.75e-12 71.2 29GZD@1|root,303X3@2|Bacteria,1TUK0@1239|Firmicutes,259H0@186801|Clostridia,3WQ8M@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04869 1235792.C808_03862 9.71e-142 435.0 COG0741@1|root,COG3064@1|root,COG0741@2|Bacteria,COG3064@2|Bacteria,1V3F0@1239|Firmicutes,249C4@186801|Clostridia,27PH1@186928|unclassified Lachnospiraceae 186801|Clostridia M CHAP domain - - - - - - - - - - - - CHAP,Lysozyme_like KKPNOBBG_04870 1235798.C817_04442 1.09e-47 157.0 2CUHA@1|root,32SVB@2|Bacteria,1V9BJ@1239|Firmicutes,24MJT@186801|Clostridia,27WUT@189330|Dorea 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04871 556261.HMPREF0240_03206 0.0 1004.0 COG3451@1|root,COG3451@2|Bacteria,1TPDR@1239|Firmicutes,248ND@186801|Clostridia,36G45@31979|Clostridiaceae 186801|Clostridia U Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - AAA_10,DUF87 KKPNOBBG_04872 1321372.AQQB01000003_gene1505 2.39e-54 172.0 COG3451@1|root,COG3451@2|Bacteria,1V6F7@1239|Firmicutes 1239|Firmicutes U PrgI family protein - - - - - - - - - - - - PrgI KKPNOBBG_04874 556261.HMPREF0240_03204 1.96e-34 122.0 2E03C@1|root,32UGX@2|Bacteria,1VC08@1239|Firmicutes,24NDJ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04876 742765.HMPREF9457_03563 2.15e-152 433.0 2DB6V@1|root,2Z7IJ@2|Bacteria,1TRNS@1239|Firmicutes,24ANE@186801|Clostridia,27W1T@189330|Dorea 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - TrbL KKPNOBBG_04877 1121422.AUMW01000014_gene1401 4.17e-43 143.0 2DMPF@1|root,32SVU@2|Bacteria,1VA0M@1239|Firmicutes,24JF3@186801|Clostridia,265G2@186807|Peptococcaceae 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_04878 1256908.HMPREF0373_02182 5.96e-297 826.0 COG3505@1|root,COG3505@2|Bacteria,1TPCF@1239|Firmicutes,2489C@186801|Clostridia,25VAZ@186806|Eubacteriaceae 186801|Clostridia U COG COG3505 Type IV secretory pathway, VirD4 components - - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf,TraG-D_C KKPNOBBG_04879 1256908.HMPREF0373_02185 8.64e-50 172.0 295P2@1|root,2ZT0F@2|Bacteria,1TT96@1239|Firmicutes,24HE4@186801|Clostridia,25WNU@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF3801) - - - - - - - - - - - - DUF3801 KKPNOBBG_04880 469596.HMPREF9488_00625 2.89e-168 489.0 COG3843@1|root,COG3843@2|Bacteria,1TPRX@1239|Firmicutes,3VNWF@526524|Erysipelotrichia 526524|Erysipelotrichia U Relaxase mobilization nuclease domain protein - - - - - - - - - - - - Relaxase KKPNOBBG_04881 742765.HMPREF9457_03571 1.41e-11 61.2 2CDK1@1|root,32VRY@2|Bacteria,1VCE4@1239|Firmicutes,24NN4@186801|Clostridia,27X0M@189330|Dorea 186801|Clostridia S Ribbon-helix-helix protein, copG family - - - - - - - - - - - - MobC,RHH_1 KKPNOBBG_04883 1232453.BAIF02000019_gene3918 7.66e-51 177.0 2EZFK@1|root,33SKU@2|Bacteria,1VRQE@1239|Firmicutes,24GB7@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04884 1232453.BAIF02000044_gene3484 3.13e-28 113.0 2EZFK@1|root,33SKU@2|Bacteria,1VRQE@1239|Firmicutes,24GB7@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04885 1410650.JHWL01000006_gene1446 5.15e-08 58.5 28PM6@1|root,2ZCAA@2|Bacteria,1V4NT@1239|Firmicutes,24HIP@186801|Clostridia,4BW1U@830|Butyrivibrio 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_04887 556261.HMPREF0240_03194 4.39e-117 347.0 COG0358@1|root,COG0358@2|Bacteria,1TSIU@1239|Firmicutes,2495Y@186801|Clostridia,36JYW@31979|Clostridiaceae 186801|Clostridia L Protein of unknown function (DUF3991) - - - - - - - - - - - - DUF3991,Toprim_2 KKPNOBBG_04888 1280698.AUJS01000043_gene3336 2.71e-64 201.0 COG2003@1|root,COG2003@2|Bacteria,1V38E@1239|Firmicutes,24M00@186801|Clostridia,27VSP@189330|Dorea 186801|Clostridia L RadC-like JAB domain - - - - - - - - - - - - RadC KKPNOBBG_04891 1232453.BAIF02000072_gene4667 4.42e-142 410.0 COG1475@1|root,COG1475@2|Bacteria,1TR7C@1239|Firmicutes,247TW@186801|Clostridia,26AD4@186813|unclassified Clostridiales 186801|Clostridia K ParB-like nuclease domain - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc KKPNOBBG_04892 556261.HMPREF0240_03188 3.48e-119 349.0 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,247R1@186801|Clostridia,36H17@31979|Clostridiaceae 186801|Clostridia D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 KKPNOBBG_04894 622312.ROSEINA2194_00641 3.23e-106 317.0 COG2253@1|root,COG2253@2|Bacteria,1TSFX@1239|Firmicutes,24C3A@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEii KKPNOBBG_04895 658086.HMPREF0994_04465 8.66e-77 235.0 COG5340@1|root,COG5340@2|Bacteria,1TQSK@1239|Firmicutes,247JC@186801|Clostridia,27KWM@186928|unclassified Lachnospiraceae 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEi_4 KKPNOBBG_04896 553973.CLOHYLEM_05412 5.61e-239 662.0 COG0526@1|root,COG0526@2|Bacteria,1VADU@1239|Firmicutes,25B1J@186801|Clostridia 186801|Clostridia CO Redoxin - - - - - - - - - - - - AhpC-TSA,Redoxin KKPNOBBG_04897 553973.CLOHYLEM_05410 4.8e-185 520.0 COG0348@1|root,COG0348@2|Bacteria,1TPHF@1239|Firmicutes,247KH@186801|Clostridia,21ZTK@1506553|Lachnoclostridium 186801|Clostridia C binding domain protein - - - - - - - - - - - - Fer4,Fer4_5 KKPNOBBG_04898 887325.HMPREF0381_1788 4.62e-09 53.1 2DTQ3@1|root,33M8V@2|Bacteria,1VMFA@1239|Firmicutes,24V02@186801|Clostridia,1HVZM@1164882|Lachnoanaerobaculum 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_04899 553973.CLOHYLEM_05408 8.09e-141 400.0 COG1136@1|root,COG1136@2|Bacteria,1TP5M@1239|Firmicutes,24BH7@186801|Clostridia,222FF@1506553|Lachnoclostridium 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_04900 553973.CLOHYLEM_05407 6.29e-272 751.0 COG0577@1|root,COG0577@2|Bacteria,1V684@1239|Firmicutes,24CM4@186801|Clostridia,222H0@1506553|Lachnoclostridium 186801|Clostridia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_04901 553973.CLOHYLEM_05406 1.8e-147 417.0 COG0745@1|root,COG0745@2|Bacteria,1TSRR@1239|Firmicutes,24AG3@186801|Clostridia,22036@1506553|Lachnoclostridium 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_04902 553973.CLOHYLEM_05405 3.12e-209 582.0 COG0642@1|root,COG0642@2|Bacteria,1VSVW@1239|Firmicutes,24DZD@186801|Clostridia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c KKPNOBBG_04903 33035.JPJF01000042_gene361 1.06e-194 551.0 COG0675@1|root,COG0675@2|Bacteria,1TT7D@1239|Firmicutes,24EJK@186801|Clostridia,3Y163@572511|Blautia 186801|Clostridia L Putative transposase DNA-binding domain - - - - - - - - - - - - OrfB_Zn_ribbon KKPNOBBG_04904 1195236.CTER_4237 2.11e-312 883.0 COG3250@1|root,COG3250@2|Bacteria,1VSYK@1239|Firmicutes,24D78@186801|Clostridia,3WSA4@541000|Ruminococcaceae 186801|Clostridia G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C KKPNOBBG_04905 1195236.CTER_4238 0.0 939.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,25BZC@186801|Clostridia,3WSA6@541000|Ruminococcaceae 1239|Firmicutes G Glycosyl hydrolases family 2 - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C KKPNOBBG_04906 1304866.K413DRAFT_4040 5.45e-163 463.0 COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,24F85@186801|Clostridia 186801|Clostridia C PFAM Aldo keto reductase family - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_04907 1195236.CTER_4240 2.94e-300 852.0 COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,25BZC@186801|Clostridia,3WSA6@541000|Ruminococcaceae 1239|Firmicutes G Glycosyl hydrolases family 2 - - - - - - - - - - - - Glyco_hydro_2,Glyco_hydro_2_C KKPNOBBG_04908 1195236.CTER_4241 2.87e-136 392.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,3WH4R@541000|Ruminococcaceae 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02026,ko:K10242 ko02010,map02010 M00206,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.23 - - BPD_transp_1 KKPNOBBG_04909 1195236.CTER_4242 1.49e-152 436.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia,3WIYD@541000|Ruminococcaceae 186801|Clostridia P ABC-type sugar transport systems permease components - - - ko:K02025,ko:K10189,ko:K10241 ko02010,map02010 M00199,M00206,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.23,3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_04910 1195236.CTER_4243 6.06e-221 620.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,3WIK9@541000|Ruminococcaceae 186801|Clostridia G PFAM Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_04911 1195236.CTER_4244 2.78e-167 495.0 COG2972@1|root,COG2972@2|Bacteria,1U0TK@1239|Firmicutes,25KJU@186801|Clostridia,3WPTI@541000|Ruminococcaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase KKPNOBBG_04912 1195236.CTER_4245 5.67e-97 309.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TPDP@1239|Firmicutes,24A5I@186801|Clostridia 186801|Clostridia T Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_04913 33035.JPJF01000015_gene4974 2.52e-115 332.0 COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,3Y025@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 bioY - - ko:K03523 ko02010,map02010 M00581,M00582 - - ko00000,ko00001,ko00002,ko02000 2.A.88.1,2.A.88.2 - - BioY KKPNOBBG_04914 1232453.BAIF02000024_gene4059 2.42e-79 244.0 2BUWD@1|root,32Q8G@2|Bacteria,1UHQJ@1239|Firmicutes,24F32@186801|Clostridia 186801|Clostridia S SatD family (SatD) - - - - - - - - - - - - SatD KKPNOBBG_04915 33035.JPJF01000015_gene4986 1.02e-50 161.0 COG1918@1|root,COG1918@2|Bacteria,1TTUK@1239|Firmicutes,25P4D@186801|Clostridia,3Y241@572511|Blautia 186801|Clostridia P FeoA - - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA KKPNOBBG_04916 33035.JPJF01000015_gene4987 1.16e-232 641.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3Y0XN@572511|Blautia 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate KKPNOBBG_04917 33035.JPJF01000015_gene4988 1.44e-311 857.0 COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,3XZS5@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - DUF4368,Recombinase,Resolvase,Zn_ribbon_recom KKPNOBBG_04919 1235802.C823_04050 3.09e-111 322.0 COG3506@1|root,COG3506@2|Bacteria,1TSXY@1239|Firmicutes,2484H@186801|Clostridia,25Y9J@186806|Eubacteriaceae 186801|Clostridia S Protein of unknown function (DUF1349) - - - ko:K09702 - - - - ko00000 - - - DUF1349 KKPNOBBG_04920 33035.JPJF01000015_gene4990 5.38e-93 272.0 COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,3Y030@572511|Blautia 186801|Clostridia F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1,dCMP_cyt_deam_2 KKPNOBBG_04921 33035.JPJF01000015_gene4991 2.8e-143 405.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,3XZXA@572511|Blautia 186801|Clostridia F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC KKPNOBBG_04922 33035.JPJF01000015_gene4992 4.45e-274 751.0 COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,3XYUY@572511|Blautia 186801|Clostridia G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - iHN637.CLJU_RS08920 Metalloenzyme KKPNOBBG_04923 33035.JPJF01000015_gene4993 1.87e-249 686.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,3XZCF@572511|Blautia 186801|Clostridia S ABC transporter substrate-binding protein PnrA-like tmpC - - ko:K07335 - - - - ko00000 - - - Bmp KKPNOBBG_04924 33035.JPJF01000015_gene4994 1.27e-212 589.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,3XYSQ@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 9.99 - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 KKPNOBBG_04925 33035.JPJF01000015_gene4995 2.97e-246 678.0 COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3XZMU@572511|Blautia 186801|Clostridia P Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 KKPNOBBG_04926 33035.JPJF01000015_gene4996 0.0 969.0 COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,3XYKD@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran KKPNOBBG_04927 33035.JPJF01000015_gene4997 4.85e-181 504.0 COG2820@1|root,COG2820@2|Bacteria,1TSEU@1239|Firmicutes,25E2U@186801|Clostridia,3XZ3Q@572511|Blautia 186801|Clostridia F Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis udp - 2.4.2.3 ko:K00757 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01876,R02484,R08229 RC00063 ko00000,ko00001,ko01000 - - - PNP_UDP_1 KKPNOBBG_04928 33035.JPJF01000015_gene4998 3.02e-164 461.0 COG2188@1|root,COG2188@2|Bacteria,1V4G6@1239|Firmicutes,249MD@186801|Clostridia 186801|Clostridia K Transcriptional regulator, GntR family - - - - - - - - - - - - GntR,UTRA KKPNOBBG_04929 33035.JPJF01000015_gene5000 0.0 1506.0 COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3Y0MS@572511|Blautia 186801|Clostridia G COG COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - Gal_mutarotas_2,Glyco_hydro_31 KKPNOBBG_04931 33035.JPJF01000119_gene1827 6.88e-175 490.0 COG4974@1|root,COG4974@2|Bacteria,1TY7M@1239|Firmicutes,24BN9@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase KKPNOBBG_04932 1235802.C823_04082 1.6e-267 743.0 COG1621@1|root,COG1621@2|Bacteria,1TPAE@1239|Firmicutes,247UU@186801|Clostridia,25VFT@186806|Eubacteriaceae 186801|Clostridia G Glycosyl hydrolases family 32 - - 3.2.1.26 ko:K01193 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R00802,R02410,R03635,R03921,R06088 RC00028,RC00077 ko00000,ko00001,ko01000 - GH32 - Glyco_hydro_32C,Glyco_hydro_32N KKPNOBBG_04933 397290.C810_02908 0.0 912.0 COG1653@1|root,COG1653@2|Bacteria,1TS6D@1239|Firmicutes,248CI@186801|Clostridia,27JZY@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial extracellular solute-binding protein - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1 KKPNOBBG_04934 397290.C810_02909 5.99e-180 505.0 COG0395@1|root,COG0395@2|Bacteria,1TQ9F@1239|Firmicutes,24846@186801|Clostridia,27KJ7@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10234 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - BPD_transp_1 KKPNOBBG_04935 1235792.C808_03984 1.24e-179 505.0 COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia,27U35@186928|unclassified Lachnospiraceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_04936 1235800.C819_01632 2.36e-195 546.0 COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,27JY6@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 KKPNOBBG_04937 33035.JPJF01000119_gene1826 8.2e-148 422.0 COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,3Y0XN@572511|Blautia 186801|Clostridia P transporter of a GTP-driven Fe(2 ) uptake system feoB2 - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate KKPNOBBG_04938 33035.JPJF01000119_gene1825 1.53e-187 523.0 COG0583@1|root,COG0583@2|Bacteria,1TP9T@1239|Firmicutes,24AYF@186801|Clostridia,3Y06U@572511|Blautia 186801|Clostridia K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_04939 1226325.HMPREF1548_01171 5.81e-128 370.0 COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,247ZD@186801|Clostridia,36DN6@31979|Clostridiaceae 186801|Clostridia S Phenazine biosynthesis protein, PhzF family - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF KKPNOBBG_04940 33035.JPJF01000119_gene1823 3.09e-165 467.0 COG0697@1|root,COG0697@2|Bacteria,1V2EI@1239|Firmicutes,24GU6@186801|Clostridia 186801|Clostridia EG Psort location CytoplasmicMembrane, score - - - - - - - - - - - - EamA KKPNOBBG_04941 537007.BLAHAN_06708 6.58e-237 662.0 COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,3XZM1@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 10.00 - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp KKPNOBBG_04942 33035.JPJF01000097_gene1732 2.31e-257 706.0 COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,3Y0R9@572511|Blautia 186801|Clostridia C Alanine dehydrogenase/PNT, N-terminal domain ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N KKPNOBBG_04943 33035.JPJF01000097_gene1731 1.74e-191 533.0 COG1737@1|root,COG1737@2|Bacteria,1UM7F@1239|Firmicutes,24B91@186801|Clostridia 186801|Clostridia K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS KKPNOBBG_04944 742733.HMPREF9469_00612 0.0 1167.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,21Z4X@1506553|Lachnoclostridium 186801|Clostridia T Psort location CytoplasmicMembrane, score 9.49 - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg KKPNOBBG_04945 658086.HMPREF0994_03731 0.0 1337.0 COG3408@1|root,COG3408@2|Bacteria,1TPY5@1239|Firmicutes,249U8@186801|Clostridia,27KIP@186928|unclassified Lachnospiraceae 186801|Clostridia G Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N KKPNOBBG_04946 658086.HMPREF0994_03732 0.0 1070.0 COG3507@1|root,COG3507@2|Bacteria,1TQBJ@1239|Firmicutes,24CFJ@186801|Clostridia,27KVD@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 KKPNOBBG_04947 658655.HMPREF0988_00677 8.08e-206 582.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,27JS0@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 1 - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 KKPNOBBG_04948 658086.HMPREF0994_03733 2.38e-151 431.0 COG1082@1|root,COG1082@2|Bacteria,1TRMY@1239|Firmicutes,24CP4@186801|Clostridia,27K31@186928|unclassified Lachnospiraceae 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_04950 658086.HMPREF0994_07239 3.16e-171 497.0 COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,27J9K@186928|unclassified Lachnospiraceae 186801|Clostridia V MatE effD - - - - - - - - - - - MatE KKPNOBBG_04951 1123314.AUIO01000001_gene1568 2.96e-271 756.0 COG1874@1|root,COG1874@2|Bacteria,1UZ5Q@1239|Firmicutes,4HT9E@91061|Bacilli 91061|Bacilli G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35 KKPNOBBG_04952 658655.HMPREF0988_00675 1.04e-151 442.0 COG2207@1|root,COG2207@2|Bacteria,1UZ0N@1239|Firmicutes,24GNF@186801|Clostridia,27M17@186928|unclassified Lachnospiraceae 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18,HTH_AraC KKPNOBBG_04953 658086.HMPREF0994_03739 2.78e-249 696.0 COG2211@1|root,COG2211@2|Bacteria,1TSEH@1239|Firmicutes,24EDK@186801|Clostridia,27TJ2@186928|unclassified Lachnospiraceae 186801|Clostridia G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 KKPNOBBG_04954 658086.HMPREF0994_03740 0.0 1138.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,27TNA@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_04955 877415.JNJQ01000009_gene973 9.99e-32 120.0 COG1309@1|root,COG1309@2|Bacteria,1VG4K@1239|Firmicutes,3VRUN@526524|Erysipelotrichia 526524|Erysipelotrichia K transcriptional regulator - - - - - - - - - - - - - KKPNOBBG_04956 397288.C806_03275 5.36e-68 213.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,27IXU@186928|unclassified Lachnospiraceae 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.30 ko:K00019,ko:K00059 ko00061,ko00072,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00072,map00333,map00650,map00780,map01040,map01100,map01130,map01212 M00083,M00088,M00572 R01361,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 KKPNOBBG_04957 397288.C806_03275 4.79e-46 156.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,27IXU@186928|unclassified Lachnospiraceae 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100,1.1.1.30 ko:K00019,ko:K00059 ko00061,ko00072,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00072,map00333,map00650,map00780,map01040,map01100,map01130,map01212 M00083,M00088,M00572 R01361,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 KKPNOBBG_04958 33035.JPJF01000051_gene769 1.57e-172 500.0 COG5598@1|root,COG5598@2|Bacteria,1UY21@1239|Firmicutes,248BQ@186801|Clostridia 186801|Clostridia H PFAM Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_04959 1235799.C818_00348 5.58e-12 70.5 COG1309@1|root,COG1309@2|Bacteria,1V7BK@1239|Firmicutes,24HI0@186801|Clostridia,27PZS@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, tetR family grdR - - - - - - - - - - - TetR_N KKPNOBBG_04960 556261.HMPREF0240_01540 5.78e-57 177.0 COG1937@1|root,COG1937@2|Bacteria,1V7GT@1239|Firmicutes,25B4K@186801|Clostridia,36W9E@31979|Clostridiaceae 186801|Clostridia S Metal-sensitive transcriptional repressor - - - ko:K21600 - - - - ko00000,ko03000 - - - Trns_repr_metal KKPNOBBG_04961 476272.RUMHYD_02287 0.0 886.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,3XZ6B@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score - - - - - - - - - - - - E1-E2_ATPase,Hydrolase KKPNOBBG_04962 1298920.KI911353_gene649 3.2e-104 304.0 COG1878@1|root,COG1878@2|Bacteria,1V2DJ@1239|Firmicutes,24HUC@186801|Clostridia,223DU@1506553|Lachnoclostridium 186801|Clostridia S Putative cyclase - - - - - - - - - - - - Cyclase KKPNOBBG_04963 1211844.CBLM010000121_gene269 8.28e-46 153.0 COG1846@1|root,COG1846@2|Bacteria,1V1U2@1239|Firmicutes,3VSB5@526524|Erysipelotrichia 526524|Erysipelotrichia K Transcriptional regulator - - - - - - - - - - - - MarR KKPNOBBG_04964 1163671.JAGI01000002_gene3765 1.99e-69 217.0 COG0194@1|root,COG0194@2|Bacteria,1V3RZ@1239|Firmicutes,24HKC@186801|Clostridia,36I87@31979|Clostridiaceae 186801|Clostridia F Guanylate kinase gmk_1 - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin KKPNOBBG_04966 697329.Rumal_3609 2.51e-152 451.0 COG2244@1|root,COG2244@2|Bacteria,1TR1W@1239|Firmicutes,24917@186801|Clostridia,3WHMM@541000|Ruminococcaceae 186801|Clostridia C Psort location CytoplasmicMembrane, score - - - - - - - - - - - - Polysacc_synt KKPNOBBG_04967 742733.HMPREF9469_01991 4.78e-161 456.0 COG1951@1|root,COG1951@2|Bacteria,1UY6Q@1239|Firmicutes,24XUA@186801|Clostridia 186801|Clostridia C Fumarate hydratase (Fumerase) - - 4.2.1.2 ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase KKPNOBBG_04968 742733.HMPREF9469_01992 6.79e-92 271.0 COG1838@1|root,COG1838@2|Bacteria,1V3K8@1239|Firmicutes,250YK@186801|Clostridia 186801|Clostridia C Fumarase C-terminus - - 4.2.1.2 ko:K01678 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase_C KKPNOBBG_04969 742733.HMPREF9469_01993 1.96e-256 705.0 COG2301@1|root,COG2301@2|Bacteria,1TSF2@1239|Firmicutes,249TC@186801|Clostridia 186801|Clostridia G C-C_Bond_Lyase of the TIM-Barrel fold - - - - - - - - - - - - C-C_Bond_Lyase KKPNOBBG_04970 742733.HMPREF9469_01994 6.08e-198 550.0 COG0826@1|root,COG0826@2|Bacteria,1TT8S@1239|Firmicutes,2527T@186801|Clostridia 186801|Clostridia O Peptidase family U32 - - - - - - - - - - - - - KKPNOBBG_04971 742733.HMPREF9469_01995 3.04e-192 543.0 COG0028@1|root,COG0028@2|Bacteria,1TSJZ@1239|Firmicutes,24AIU@186801|Clostridia,22238@1506553|Lachnoclostridium 186801|Clostridia EH Thiamine pyrophosphate enzyme, N-terminal TPP binding domain aepY - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N KKPNOBBG_04972 742733.HMPREF9469_01996 3.3e-176 497.0 COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,25B10@186801|Clostridia 186801|Clostridia C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red KKPNOBBG_04973 742733.HMPREF9469_01997 1.67e-216 610.0 COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,24BFZ@186801|Clostridia 186801|Clostridia S MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD KKPNOBBG_04974 1410624.JNKK01000015_gene1479 7.57e-97 302.0 COG0151@1|root,COG0151@2|Bacteria,1TRZ2@1239|Firmicutes,2497Y@186801|Clostridia,27P12@186928|unclassified Lachnospiraceae 186801|Clostridia F ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4,GARS_A KKPNOBBG_04975 944565.HMPREF9127_0876 1.03e-74 236.0 COG2148@1|root,COG2148@2|Bacteria,1TP49@1239|Firmicutes,249F1@186801|Clostridia,22JAN@1570339|Peptoniphilaceae 186801|Clostridia M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf KKPNOBBG_04976 768706.Desor_5122 1.2e-179 509.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,25ZZI@186807|Peptococcaceae 186801|Clostridia E PFAM DegT DnrJ EryC1 StrS aminotransferase family - - 2.6.1.33 ko:K20429 - - R02773 RC00006,RC00781 ko00000,ko01000 - - - DegT_DnrJ_EryC1 KKPNOBBG_04978 33035.JPJF01000042_gene361 3.65e-225 629.0 COG0675@1|root,COG0675@2|Bacteria,1TT7D@1239|Firmicutes,24EJK@186801|Clostridia,3Y163@572511|Blautia 186801|Clostridia L Putative transposase DNA-binding domain - - - - - - - - - - - - OrfB_Zn_ribbon KKPNOBBG_04979 33035.JPJF01000084_gene5087 2.43e-247 682.0 COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,24B23@186801|Clostridia,3Y00V@572511|Blautia 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_3,Phage_integrase KKPNOBBG_04980 33035.JPJF01000084_gene5086 9e-230 639.0 COG2199@1|root,COG2199@2|Bacteria,1UZKR@1239|Firmicutes,25EAM@186801|Clostridia 186801|Clostridia T diguanylate cyclase - - - - - - - - - - - - GGDEF KKPNOBBG_04981 33035.JPJF01000083_gene5103 0.0 1142.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04982 33035.JPJF01000083_gene5104 0.0 1090.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3XZJG@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran KKPNOBBG_04983 1151292.QEW_0936 4.24e-95 283.0 COG1670@1|root,COG1670@2|Bacteria,1UYRS@1239|Firmicutes,249WX@186801|Clostridia 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 KKPNOBBG_04984 33035.JPJF01000083_gene5106 1.8e-190 530.0 COG4977@1|root,COG4977@2|Bacteria,1V166@1239|Firmicutes,25EAI@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_04985 33035.JPJF01000083_gene5107 7.74e-204 566.0 COG0697@1|root,COG0697@2|Bacteria,1TRH8@1239|Firmicutes,24B85@186801|Clostridia,3Y05N@572511|Blautia 186801|Clostridia EG COG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA KKPNOBBG_04987 33035.JPJF01000083_gene5112 0.0 883.0 COG0554@1|root,COG0554@2|Bacteria,1TRX3@1239|Firmicutes,24A76@186801|Clostridia,3XZRZ@572511|Blautia 186801|Clostridia C FGGY family of carbohydrate kinases, C-terminal domain - - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N KKPNOBBG_04988 33035.JPJF01000083_gene5113 4.29e-204 566.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3XZKV@572511|Blautia 186801|Clostridia G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C KKPNOBBG_04989 33035.JPJF01000083_gene5114 1.18e-189 527.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,3XZKM@572511|Blautia 186801|Clostridia G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N KKPNOBBG_04990 33035.JPJF01000083_gene5115 0.0 884.0 COG2407@1|root,COG2407@2|Bacteria,1TQDX@1239|Firmicutes,247N8@186801|Clostridia,3XZNR@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Arabinose_Isome,Fucose_iso_C KKPNOBBG_04991 33035.JPJF01000083_gene5117 8.12e-317 869.0 COG5512@1|root,COG5512@2|Bacteria,1TR27@1239|Firmicutes,247Z8@186801|Clostridia 186801|Clostridia S Domain of unknown function (DUF5060) - - - - - - - - - - - - DUF4038,DUF5060 KKPNOBBG_04992 33035.JPJF01000083_gene5118 4.11e-171 481.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3XZXP@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K10119 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 KKPNOBBG_04993 33035.JPJF01000083_gene5119 2.15e-171 483.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XYIT@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02025,ko:K05814,ko:K10201,ko:K17316 ko02010,map02010 M00198,M00205,M00207,M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.18,3.A.1.1.24,3.A.1.1.3,3.A.1.1.30 - - BPD_transp_1 KKPNOBBG_04994 33035.JPJF01000083_gene5120 2.38e-205 580.0 COG1653@1|root,COG1653@2|Bacteria,1TRY7@1239|Firmicutes,24E82@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_04995 180332.JTGN01000005_gene2788 3.81e-173 490.0 COG1609@1|root,COG1609@2|Bacteria,1UXXV@1239|Firmicutes,24A5P@186801|Clostridia 186801|Clostridia K Psort location Cytoplasmic, score - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 KKPNOBBG_04996 33035.JPJF01000083_gene5123 1.45e-126 361.0 COG0558@1|root,COG0558@2|Bacteria,1V4YR@1239|Firmicutes,24FWZ@186801|Clostridia,3Y08W@572511|Blautia 186801|Clostridia I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf KKPNOBBG_04997 33035.JPJF01000083_gene5125 1.23e-113 328.0 COG1102@1|root,COG1102@2|Bacteria,1V82X@1239|Firmicutes,24KX9@186801|Clostridia,3Y0GP@572511|Blautia 186801|Clostridia F Cytidylate kinase-like family - - - - - - - - - - - - Cytidylate_kin2 KKPNOBBG_04998 33035.JPJF01000083_gene5126 1.52e-144 409.0 COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,24AGM@186801|Clostridia,3XZHZ@572511|Blautia 186801|Clostridia M Psort location CytoplasmicMembrane, score lrgB - - - - - - - - - - - LrgB KKPNOBBG_04999 33035.JPJF01000083_gene5127 7e-73 219.0 COG1380@1|root,COG1380@2|Bacteria,1VEN4@1239|Firmicutes,24MMB@186801|Clostridia,3Y0DT@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 lrgA - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA KKPNOBBG_05000 411459.RUMOBE_02918 6.49e-75 230.0 COG2206@1|root,COG2206@2|Bacteria,1UI74@1239|Firmicutes,25EC7@186801|Clostridia 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - HD KKPNOBBG_05001 33035.JPJF01000083_gene5128 0.0 1338.0 COG1874@1|root,COG1874@2|Bacteria,1TQN6@1239|Firmicutes,2488V@186801|Clostridia,3XYX5@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 pbg - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M KKPNOBBG_05002 33035.JPJF01000083_gene5129 0.0 1966.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,248H7@186801|Clostridia,3XZCD@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 lacZ - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N KKPNOBBG_05003 33035.JPJF01000083_gene5130 1.32e-182 509.0 COG0395@1|root,COG0395@2|Bacteria,1TSGI@1239|Firmicutes,24BDH@186801|Clostridia,3XZD9@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K10190 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_05004 33035.JPJF01000083_gene5131 1.41e-200 556.0 COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,2494U@186801|Clostridia,3XYXH@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02025,ko:K10189 ko02010,map02010 M00199,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.4 - - BPD_transp_1 KKPNOBBG_05005 33035.JPJF01000083_gene5132 1.51e-286 788.0 COG1653@1|root,COG1653@2|Bacteria,1TQ0V@1239|Firmicutes,2481M@186801|Clostridia,3XZJC@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein lacE - - ko:K10188 ko02010,map02010 M00199 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.4 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_05006 33035.JPJF01000083_gene5133 1.33e-228 629.0 COG2207@1|root,COG2207@2|Bacteria,1V0IW@1239|Firmicutes,24BME@186801|Clostridia,3Y09S@572511|Blautia 186801|Clostridia K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_05008 33035.JPJF01000083_gene5135 1.18e-191 533.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,3Y2CH@572511|Blautia 186801|Clostridia E Diaminopimelate epimerase dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase KKPNOBBG_05009 33035.JPJF01000083_gene5136 2.65e-184 514.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZ8Y@1239|Firmicutes,248SM@186801|Clostridia,3XZ0Y@572511|Blautia 186801|Clostridia K transcriptional regulator (AraC - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05010 33035.JPJF01000083_gene5137 3.05e-168 474.0 COG0373@1|root,COG0373@2|Bacteria,1UI1H@1239|Firmicutes,249GW@186801|Clostridia,3Y0AN@572511|Blautia 186801|Clostridia H Psort location Cytoplasmic, score 8.87 spoVFA - - ko:K06410 - - - - ko00000 - - - 2-Hacid_dh_C,DpaA_N,Shikimate_DH KKPNOBBG_05011 33035.JPJF01000083_gene5138 4.73e-127 362.0 COG0452@1|root,COG0452@2|Bacteria,1TQPT@1239|Firmicutes,24HE6@186801|Clostridia,3XZPE@572511|Blautia 186801|Clostridia H dipicolinate synthase subunit B spoVFB - - ko:K06411 - - - - ko00000 - - - Flavoprotein KKPNOBBG_05012 33035.JPJF01000083_gene5139 0.0 1108.0 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,3XYHI@572511|Blautia 186801|Clostridia E Psort location Cytoplasmic, score 8.87 asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 KKPNOBBG_05013 33035.JPJF01000083_gene5141 3.18e-152 429.0 COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,247X5@186801|Clostridia,3XZMC@572511|Blautia 186801|Clostridia S Uncharacterised protein family UPF0066 tsaA - - - - - - - - - - - UPF0066 KKPNOBBG_05014 33035.JPJF01000083_gene5143 1.75e-306 845.0 COG1132@1|root,COG1132@2|Bacteria,1TSRV@1239|Firmicutes,248P6@186801|Clostridia,3XZUA@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 10.00 - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran KKPNOBBG_05015 33035.JPJF01000083_gene5144 1.18e-202 566.0 COG0640@1|root,COG0640@2|Bacteria,1V2A1@1239|Firmicutes,24RXK@186801|Clostridia 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 KKPNOBBG_05016 33035.JPJF01000083_gene5146 1.39e-234 651.0 COG2199@1|root,COG2199@2|Bacteria,1TQG9@1239|Firmicutes,249KA@186801|Clostridia,3Y0T6@572511|Blautia 186801|Clostridia T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF KKPNOBBG_05017 33035.JPJF01000083_gene5147 0.0 1268.0 COG2200@1|root,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia,3Y288@572511|Blautia 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 KKPNOBBG_05018 33035.JPJF01000083_gene5148 4.05e-154 434.0 2CET8@1|root,2Z7N2@2|Bacteria,1TT9T@1239|Firmicutes,24AN8@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - - KKPNOBBG_05019 545243.BAEV01000053_gene3733 1.04e-41 142.0 COG0454@1|root,COG0454@2|Bacteria,1VD9I@1239|Firmicutes,24MT9@186801|Clostridia,36N6C@31979|Clostridiaceae 186801|Clostridia K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 KKPNOBBG_05020 33035.JPJF01000083_gene5151 2.27e-227 632.0 2EQDY@1|root,33HZZ@2|Bacteria,1VKNF@1239|Firmicutes,24HVJ@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05021 33035.JPJF01000083_gene5152 4.34e-111 321.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_05023 471855.Shel_05290 9.83e-24 100.0 2A35S@1|root,2ZBW6@2|Bacteria 2|Bacteria S L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase KKPNOBBG_05024 33035.JPJF01000083_gene5153 1.05e-253 704.0 COG0642@1|root,COG2205@2|Bacteria,1TS1G@1239|Firmicutes,248TF@186801|Clostridia,3Y01W@572511|Blautia 186801|Clostridia T subtilin biosynthesis sensor protein SpaK - - 2.7.13.3 ko:K20487 ko02020,ko02024,map02020,map02024 M00816 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA KKPNOBBG_05025 33035.JPJF01000083_gene5154 1.48e-143 406.0 COG0745@1|root,COG0745@2|Bacteria,1TQ0D@1239|Firmicutes,248WX@186801|Clostridia,3XZUE@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - ko:K20488 ko02020,ko02024,map02020,map02024 M00816 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C KKPNOBBG_05026 33035.JPJF01000083_gene5155 1.4e-121 352.0 COG4200@1|root,COG4200@2|Bacteria,1V4AY@1239|Firmicutes,24EXR@186801|Clostridia,3Y0KJ@572511|Blautia 186801|Clostridia S Lantibiotic protection ABC transporter permease subunit, MutG family mutG - - ko:K20492 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00817 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 - - ABC2_membrane_4 KKPNOBBG_05027 33035.JPJF01000083_gene5156 9.66e-133 380.0 COG4200@1|root,COG4200@2|Bacteria,1TRRE@1239|Firmicutes,24AHY@186801|Clostridia 186801|Clostridia S Lantibiotic protection ABC transporter permease subunit, MutE EpiE family - - - ko:K20491 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00817 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 - - ABC2_membrane_4 KKPNOBBG_05028 33035.JPJF01000083_gene5157 6.77e-154 433.0 COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,253U3@186801|Clostridia,3XZKN@572511|Blautia 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K20490 ko02010,ko02020,ko02024,map02010,map02020,map02024 M00254,M00817 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.1,3.A.1.124.2,3.A.1.124.6 - - ABC_tran KKPNOBBG_05029 33035.JPJF01000083_gene5158 1.28e-249 690.0 COG1277@1|root,COG1277@2|Bacteria,1UTUG@1239|Firmicutes,25EAK@186801|Clostridia 186801|Clostridia S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - ABC2_membrane_2,ABC2_membrane_3 KKPNOBBG_05030 33035.JPJF01000083_gene5159 4.37e-184 514.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,3XZE4@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05031 33035.JPJF01000083_gene5160 6.17e-140 400.0 2CJ98@1|root,326JR@2|Bacteria,1V6ZE@1239|Firmicutes,25DE6@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05032 33035.JPJF01000083_gene5161 1.53e-95 281.0 COG1595@1|root,COG1595@2|Bacteria,1VBJI@1239|Firmicutes,24NKR@186801|Clostridia,3Y1WC@572511|Blautia 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_05033 33035.JPJF01000004_gene2018 9.48e-111 328.0 COG4942@1|root,COG4942@2|Bacteria 2|Bacteria D peptidase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - PDDEXK_2 KKPNOBBG_05034 33035.JPJF01000098_gene1762 5.42e-228 627.0 COG1082@1|root,COG1082@2|Bacteria,1UZXE@1239|Firmicutes,24ECM@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_05035 33035.JPJF01000098_gene1763 4.38e-210 581.0 COG1082@1|root,COG1082@2|Bacteria,1TPZ2@1239|Firmicutes,24AF7@186801|Clostridia 186801|Clostridia G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) iolE - 4.2.1.44 ko:K03335 ko00562,ko01100,ko01120,map00562,map01100,map01120 - R02782,R05659 RC00782,RC01448 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_05036 33035.JPJF01000098_gene1764 0.0 1325.0 COG1102@1|root,COG2211@1|root,COG1102@2|Bacteria,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia 186801|Clostridia G Psort location CytoplasmicMembrane, score 10.00 gph - - ko:K03292 - - - - ko00000 2.A.2 - - Cytidylate_kin2,MFS_2 KKPNOBBG_05037 33035.JPJF01000098_gene1765 1.51e-202 561.0 COG1082@1|root,COG1082@2|Bacteria,1TS20@1239|Firmicutes,24E7U@186801|Clostridia 186801|Clostridia G Xylose isomerase-like TIM barrel - - 5.3.99.11 ko:K06606 ko00562,ko01120,map00562,map01120 - R09952 RC01513 ko00000,ko00001,ko01000 - - - AP_endonuc_2 KKPNOBBG_05038 33035.JPJF01000098_gene1766 3.33e-241 662.0 COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,24CRQ@186801|Clostridia 186801|Clostridia S Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively iolG - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C KKPNOBBG_05039 33035.JPJF01000098_gene1767 1.13e-227 629.0 COG1609@1|root,COG1609@2|Bacteria,1TSRM@1239|Firmicutes,24BFS@186801|Clostridia 186801|Clostridia K Bacterial regulatory proteins, lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_4 KKPNOBBG_05040 556261.HMPREF0240_01647 9.87e-138 397.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,36I3B@31979|Clostridiaceae 186801|Clostridia K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_05041 1158607.UAU_02140 5.77e-184 530.0 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,4HJPK@91061|Bacilli,4B6PF@81852|Enterococcaceae 91061|Bacilli G Vacuole effluxer Atg22 like - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_05042 33035.JPJF01000098_gene1774 0.0 1063.0 COG0577@1|root,COG0577@2|Bacteria,1TSMB@1239|Firmicutes,24ABI@186801|Clostridia,3Y1FY@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - - - - - - - - - - FtsX KKPNOBBG_05043 33035.JPJF01000098_gene1775 2.9e-171 478.0 COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,3Y191@572511|Blautia 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05044 33035.JPJF01000098_gene1776 2.14e-221 613.0 COG1879@1|root,COG1879@2|Bacteria,1TQW5@1239|Firmicutes,249PS@186801|Clostridia,3XZ2X@572511|Blautia 186801|Clostridia G Periplasmic binding protein domain - - - ko:K10540 ko02010,ko02030,map02010,map02030 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - Peripla_BP_4 KKPNOBBG_05045 33035.JPJF01000098_gene1777 5.72e-189 530.0 COG1879@1|root,COG1879@2|Bacteria,1UD4W@1239|Firmicutes,24AYQ@186801|Clostridia,3XZS6@572511|Blautia 186801|Clostridia G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 KKPNOBBG_05046 33035.JPJF01000098_gene1778 0.0 1134.0 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3XZ6E@572511|Blautia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_05047 33035.JPJF01000098_gene1779 0.0 985.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,3XZ1E@572511|Blautia 186801|Clostridia T Psort location Cytoplasmic, score 9.98 - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_05048 33035.JPJF01000098_gene1780 0.0 985.0 COG3064@1|root,COG4211@1|root,COG3064@2|Bacteria,COG4211@2|Bacteria,1UI1K@1239|Firmicutes,25EAQ@186801|Clostridia,3XZJQ@572511|Blautia 186801|Clostridia G Branched-chain amino acid transport system / permease component - - - ko:K10541 ko02010,map02010 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - BPD_transp_2 KKPNOBBG_05049 33035.JPJF01000098_gene1781 0.0 972.0 COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3XZ1W@572511|Blautia 186801|Clostridia P import. Responsible for energy coupling to the transport system mglA - 3.6.3.17 ko:K10542 ko02010,map02010 M00214 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.3 - - ABC_tran KKPNOBBG_05050 33035.JPJF01000098_gene1782 3.09e-283 777.0 COG1879@1|root,COG1879@2|Bacteria,1TT3I@1239|Firmicutes,247SI@186801|Clostridia,3XZQM@572511|Blautia 186801|Clostridia G Periplasmic binding protein domain mglB - - ko:K10540 ko02010,ko02030,map02010,map02030 M00214 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.3 - - Peripla_BP_4 KKPNOBBG_05051 457421.CBFG_03119 5.48e-135 387.0 COG1136@1|root,COG1136@2|Bacteria,1TQU8@1239|Firmicutes,24AM8@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05052 457421.CBFG_03120 0.0 1145.0 COG0577@1|root,COG0577@2|Bacteria,1TQ3S@1239|Firmicutes,248TI@186801|Clostridia 186801|Clostridia V ABC-type transport system involved in lipoprotein release permease component - - - - - - - - - - - - FtsX KKPNOBBG_05053 457421.CBFG_03121 1.97e-221 620.0 COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,26CRS@186813|unclassified Clostridiales 186801|Clostridia EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 KKPNOBBG_05054 457421.CBFG_03122 3.39e-120 346.0 COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,24F9Q@186801|Clostridia 186801|Clostridia K transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N KKPNOBBG_05055 658086.HMPREF0994_07268 6.11e-69 239.0 COG4219@1|root,COG5184@1|root,COG4219@2|Bacteria,COG5184@2|Bacteria,1TP3Z@1239|Firmicutes,24A30@186801|Clostridia,27R8K@186928|unclassified Lachnospiraceae 186801|Clostridia DKTZ BlaR1 peptidase M56 - - - - - - - - - - - - Peptidase_M56 KKPNOBBG_05056 33035.JPJF01000045_gene1022 2.71e-144 409.0 COG3279@1|root,COG3279@2|Bacteria,1V3QY@1239|Firmicutes,24IT9@186801|Clostridia,3Y1IK@572511|Blautia 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_05057 33035.JPJF01000045_gene1024 6.14e-232 647.0 COG3290@1|root,COG3290@2|Bacteria,1V48N@1239|Firmicutes,24CD0@186801|Clostridia,3Y0IS@572511|Blautia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5,SPOB_a KKPNOBBG_05058 33035.JPJF01000045_gene1037 1.12e-285 782.0 COG1228@1|root,COG1228@2|Bacteria,1TQQ0@1239|Firmicutes,24EHA@186801|Clostridia 186801|Clostridia Q Psort location Cytoplasmic, score - - - - - - - - - - - - Amidohydro_1 KKPNOBBG_05059 33035.JPJF01000045_gene1038 6.93e-79 235.0 COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,25035@186801|Clostridia 186801|Clostridia J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP KKPNOBBG_05060 33035.JPJF01000045_gene1039 0.0 1235.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3Y0Z1@572511|Blautia 186801|Clostridia C Succinyl-CoA ligase like flavodoxin domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig KKPNOBBG_05061 33035.JPJF01000045_gene1040 5.38e-113 325.0 COG1014@1|root,COG1014@2|Bacteria,1V3QA@1239|Firmicutes,24INU@186801|Clostridia 186801|Clostridia C Pyruvate ferredoxin/flavodoxin oxidoreductase - - - - - - - - - - - - POR KKPNOBBG_05062 33035.JPJF01000045_gene1041 7.33e-183 508.0 COG1013@1|root,COG1013@2|Bacteria,1UNVM@1239|Firmicutes,25CAM@186801|Clostridia 186801|Clostridia C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - - - - - - - - - - TPP_enzyme_C KKPNOBBG_05063 33035.JPJF01000045_gene1042 4.29e-249 684.0 COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia 186801|Clostridia C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR_N KKPNOBBG_05064 33035.JPJF01000045_gene1043 1.58e-41 136.0 COG2221@1|root,COG2221@2|Bacteria 2|Bacteria C Nitrite and sulphite reductase 4Fe-4S - - 1.2.7.3 ko:K00176 ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200 M00009,M00011,M00173,M00620 R01197 RC00004,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_6 KKPNOBBG_05065 33035.JPJF01000045_gene1044 0.0 900.0 COG5598@1|root,COG5598@2|Bacteria,1V15E@1239|Firmicutes,24CMY@186801|Clostridia 2|Bacteria H PFAM Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_05066 33035.JPJF01000045_gene1045 1.85e-147 418.0 COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia 186801|Clostridia K transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR KKPNOBBG_05067 33035.JPJF01000045_gene1046 9.7e-184 514.0 COG0697@1|root,COG0697@2|Bacteria,1VJPP@1239|Firmicutes,24SJ6@186801|Clostridia 186801|Clostridia EG EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_05068 33035.JPJF01000045_gene1047 0.0 923.0 COG5598@1|root,COG5598@2|Bacteria,1UZPX@1239|Firmicutes,24FC6@186801|Clostridia 186801|Clostridia H Trimethylamine methyltransferase (MTTB) - - 2.1.1.250 ko:K14083 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09124,R10016 RC00035,RC00732,RC01144,RC02984 ko00000,ko00001,ko00002,ko01000 - - - MTTB KKPNOBBG_05069 33035.JPJF01000045_gene1048 9.36e-143 404.0 COG5012@1|root,COG5012@2|Bacteria,1V55S@1239|Firmicutes,24HXM@186801|Clostridia 186801|Clostridia S cobalamin binding protein - - - - - - - - - - - - B12-binding,B12-binding_2 KKPNOBBG_05070 33035.JPJF01000045_gene1049 1.65e-283 777.0 COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1U23Q@1239|Firmicutes,24CZ9@186801|Clostridia 186801|Clostridia K Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain - - - - - - - - - - - - HTH_18,HTH_AraC,PocR KKPNOBBG_05071 33035.JPJF01000045_gene1050 2.2e-140 399.0 COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia,3XZPM@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.26 yugP - - ko:K06973 - - - - ko00000 - - - Zn_peptidase_2 KKPNOBBG_05072 33035.JPJF01000045_gene1051 8.4e-93 271.0 COG1786@1|root,COG1786@2|Bacteria,1V9ZT@1239|Firmicutes,24N2I@186801|Clostridia 186801|Clostridia S Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 KKPNOBBG_05073 33035.JPJF01000045_gene1052 0.0 867.0 COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 KKPNOBBG_05074 33035.JPJF01000045_gene1053 0.0 991.0 COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia 186801|Clostridia M Belongs to the BCCT transporter (TC 2.A.15) family - - - - - - - - - - - - BCCT KKPNOBBG_05075 33035.JPJF01000045_gene1054 2.06e-196 546.0 COG0583@1|root,COG0583@2|Bacteria,1TP3E@1239|Firmicutes,248HI@186801|Clostridia,3Y07S@572511|Blautia 186801|Clostridia K LysR substrate binding domain cpsY - - - - - - - - - - - HTH_1,LysR_substrate KKPNOBBG_05076 1196323.ALKF01000195_gene2022 2.24e-49 174.0 COG3173@1|root,COG3173@2|Bacteria,1U6NE@1239|Firmicutes,4IRID@91061|Bacilli,26WCY@186822|Paenibacillaceae 91061|Bacilli S Fructosamine kinase - - - - - - - - - - - - APH KKPNOBBG_05077 33035.JPJF01000073_gene4441 1.68e-264 732.0 COG0642@1|root,COG2205@2|Bacteria,1TS12@1239|Firmicutes,24AAW@186801|Clostridia,3Y1EW@572511|Blautia 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_05078 33035.JPJF01000073_gene4440 4.59e-146 414.0 COG0745@1|root,COG0745@2|Bacteria,1TYPK@1239|Firmicutes,247Y9@186801|Clostridia,3Y1K4@572511|Blautia 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_05079 33035.JPJF01000073_gene4439 1.27e-198 552.0 COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,253U3@186801|Clostridia,3Y1FM@572511|Blautia 186801|Clostridia V AAA domain, putative AbiEii toxin, Type IV TA system bcrA_2 - - ko:K01990,ko:K20459 ko02010,map02010 M00254,M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC_tran KKPNOBBG_05080 33035.JPJF01000073_gene4438 6.27e-155 438.0 COG4200@1|root,COG4200@2|Bacteria,1V273@1239|Firmicutes,24HVF@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - ko:K20460 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC2_membrane_4 KKPNOBBG_05081 33035.JPJF01000073_gene4437 1.48e-159 448.0 COG4200@1|root,COG4200@2|Bacteria,1TSD5@1239|Firmicutes,24DU9@186801|Clostridia,3Y1WR@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K20461 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC2_membrane_4 KKPNOBBG_05082 33035.JPJF01000073_gene4436 4.01e-296 816.0 COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,248XI@186801|Clostridia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran_2 KKPNOBBG_05083 33035.JPJF01000073_gene4435 1.09e-162 456.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia 186801|Clostridia V Abc transporter - - - ko:K01990,ko:K19340 ko02010,map02010 M00254,M00762 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.132.2 - - ABC_tran KKPNOBBG_05084 33035.JPJF01000073_gene4434 5.45e-109 316.0 COG0640@1|root,COG0640@2|Bacteria,1TX6K@1239|Firmicutes,25IRQ@186801|Clostridia,3Y26I@572511|Blautia 186801|Clostridia K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 KKPNOBBG_05085 180332.JTGN01000006_gene3279 0.0 1161.0 COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,248SQ@186801|Clostridia 186801|Clostridia V Psort location CytoplasmicMembrane, score - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD KKPNOBBG_05086 556261.HMPREF0240_02934 6.77e-142 403.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,36EH8@31979|Clostridiaceae 186801|Clostridia V ABC transporter, ATP-binding protein - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05087 33035.JPJF01000073_gene4433 1.13e-102 298.0 COG3695@1|root,COG3695@2|Bacteria,1TPJI@1239|Firmicutes,249H6@186801|Clostridia,3XZ1A@572511|Blautia 186801|Clostridia L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - - - - - - - - - - DNA_binding_1 KKPNOBBG_05088 33035.JPJF01000073_gene4432 2.08e-123 355.0 COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,248YH@186801|Clostridia,3Y1ZD@572511|Blautia 186801|Clostridia S GyrI-like small molecule binding domain - - - - - - - - - - - - GyrI-like KKPNOBBG_05089 1235792.C808_01557 9.29e-119 345.0 2C3WU@1|root,303AS@2|Bacteria,1V61S@1239|Firmicutes,24J09@186801|Clostridia,27RJ1@186928|unclassified Lachnospiraceae 186801|Clostridia - - - - - ko:K16905 ko02010,map02010 M00224 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - - KKPNOBBG_05090 1235792.C808_01556 8.54e-110 321.0 COG1668@1|root,COG1668@2|Bacteria,1V2WV@1239|Firmicutes,24IFP@186801|Clostridia,27RIP@186928|unclassified Lachnospiraceae 186801|Clostridia CP transmembrane transport - - - ko:K16906 ko02010,map02010 M00224 - - ko00000,ko00001,ko00002,ko02000 3.A.1 - - - KKPNOBBG_05091 658086.HMPREF0994_03290 3.02e-174 489.0 COG1131@1|root,COG1131@2|Bacteria,1TRNT@1239|Firmicutes,24B5J@186801|Clostridia,27M57@186928|unclassified Lachnospiraceae 186801|Clostridia V ATPases associated with a variety of cellular activities - - - ko:K01990,ko:K16907 ko02010,map02010 M00224,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05092 1235792.C808_01554 7.4e-103 301.0 COG1309@1|root,COG1309@2|Bacteria,1V2EH@1239|Firmicutes,24H5Z@186801|Clostridia,27PUD@186928|unclassified Lachnospiraceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_05093 33035.JPJF01000073_gene4427 0.0 924.0 28IHZ@1|root,2Z8J5@2|Bacteria,1TQV6@1239|Firmicutes,249TE@186801|Clostridia,3Y0MJ@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - KKPNOBBG_05094 33035.JPJF01000073_gene4426 4.48e-144 409.0 COG1131@1|root,COG1131@2|Bacteria,1TRTC@1239|Firmicutes,2488R@186801|Clostridia 186801|Clostridia V abc transporter atp-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05095 33035.JPJF01000073_gene4425 0.0 1883.0 COG1361@1|root,COG3386@1|root,COG1361@2|Bacteria,COG3386@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia 186801|Clostridia M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,DUF3794,SdrD_B KKPNOBBG_05096 33035.JPJF01000073_gene4423 3.76e-267 733.0 COG2230@1|root,COG2230@2|Bacteria,1TSG4@1239|Firmicutes,248GV@186801|Clostridia,3XZP3@572511|Blautia 186801|Clostridia M Mycolic acid cyclopropane synthetase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS KKPNOBBG_05097 1232453.BAIF02000084_gene388 1.46e-174 498.0 2DBN9@1|root,2ZA33@2|Bacteria,1U6HI@1239|Firmicutes,24G5F@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05098 1232453.BAIF02000084_gene387 9.7e-148 429.0 2BZQD@1|root,2Z7JR@2|Bacteria,1UZDH@1239|Firmicutes,248UH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - ABC2_membrane_2 KKPNOBBG_05099 1232453.BAIF02000084_gene386 1.49e-153 437.0 COG1131@1|root,COG1131@2|Bacteria,1TRJH@1239|Firmicutes,247XQ@186801|Clostridia,26A14@186813|unclassified Clostridiales 186801|Clostridia V ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran KKPNOBBG_05101 33035.JPJF01000073_gene4421 8.77e-101 295.0 COG1595@1|root,COG1595@2|Bacteria,1VH54@1239|Firmicutes,25MQV@186801|Clostridia,3Y22P@572511|Blautia 186801|Clostridia K Sigma-70, region 4 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_05102 33035.JPJF01000073_gene4420 4.86e-63 195.0 2EF6F@1|root,338ZI@2|Bacteria,1VI9H@1239|Firmicutes,24PYC@186801|Clostridia 186801|Clostridia S Bacterial PH domain - - - - - - - - - - - - bPH_4 KKPNOBBG_05105 476272.RUMHYD_00977 8.47e-30 112.0 COG2172@1|root,COG2172@2|Bacteria,1VGIQ@1239|Firmicutes,25DQ1@186801|Clostridia 186801|Clostridia T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 KKPNOBBG_05106 476272.RUMHYD_00976 2.93e-31 112.0 COG1366@1|root,COG1366@2|Bacteria,1VB77@1239|Firmicutes,24T7M@186801|Clostridia,3Y25G@572511|Blautia 186801|Clostridia T STAS domain - - - - - - - - - - - - STAS KKPNOBBG_05108 476272.RUMHYD_00984 0.0 1236.0 COG2274@1|root,COG2274@2|Bacteria,1TRMR@1239|Firmicutes,248Z2@186801|Clostridia 186801|Clostridia V bacteriocin system ABC transporter, ATP-binding protein - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran KKPNOBBG_05109 476272.RUMHYD_00983 0.0 1099.0 COG2274@1|root,COG2274@2|Bacteria,1V77J@1239|Firmicutes,25E7C@186801|Clostridia 186801|Clostridia V ABC transporter, transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran,Peptidase_C39 KKPNOBBG_05110 476272.RUMHYD_00982 6.15e-120 377.0 COG0845@1|root,COG0845@2|Bacteria,1V0EP@1239|Firmicutes,24DYZ@186801|Clostridia 186801|Clostridia M TIGRFAM NHLM bacteriocin system secretion protein - - - ko:K02022 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 KKPNOBBG_05111 476272.RUMHYD_00981 5.09e-42 145.0 COG1595@1|root,COG1595@2|Bacteria,1V4E2@1239|Firmicutes 1239|Firmicutes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 KKPNOBBG_05113 476272.RUMHYD_00980 2.17e-181 525.0 COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia 186801|Clostridia KT stage II sporulation protein E - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - 5TM-5TMR_LYT,SpoIIE,cNMP_binding KKPNOBBG_05115 476272.RUMHYD_00975 1.27e-92 283.0 2C5KF@1|root,323ZW@2|Bacteria,1VWWE@1239|Firmicutes,2529M@186801|Clostridia 186801|Clostridia S UPF0489 domain - - - - - - - - - - - - UPF0489 KKPNOBBG_05116 476272.RUMHYD_00974 1.15e-70 218.0 COG1443@1|root,COG1443@2|Bacteria,1V6RW@1239|Firmicutes,24JWV@186801|Clostridia,3Y1TZ@572511|Blautia 186801|Clostridia I NUDIX domain - - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX KKPNOBBG_05117 476272.RUMHYD_00973 1.88e-247 702.0 COG0535@1|root,COG3751@1|root,COG0535@2|Bacteria,COG3751@2|Bacteria,1VC7I@1239|Firmicutes,24NBM@186801|Clostridia 186801|Clostridia C radical SAM domain protein - - - - - - - - - - - - - KKPNOBBG_05123 33035.JPJF01000073_gene4416 4.43e-227 625.0 COG0407@1|root,COG0407@2|Bacteria,1UZD2@1239|Firmicutes,24C43@186801|Clostridia,3Y1E6@572511|Blautia 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) - - - - - - - - - - - - URO-D KKPNOBBG_05124 33035.JPJF01000073_gene4415 8.17e-302 826.0 COG2211@1|root,COG2211@2|Bacteria,1UJ7Q@1239|Firmicutes,24DJ1@186801|Clostridia 186801|Clostridia G TIGRFAM sugar (Glycoside-Pentoside-Hexuronide) transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 KKPNOBBG_05125 33035.JPJF01000073_gene4414 0.0 949.0 COG2508@1|root,COG2508@2|Bacteria,1VIT3@1239|Firmicutes,24JXW@186801|Clostridia,3Y0T9@572511|Blautia 186801|Clostridia QT PucR C-terminal helix-turn-helix domain - - - - - - - - - - - - HTH_30 KKPNOBBG_05126 33035.JPJF01000073_gene4413 2.14e-203 564.0 COG0657@1|root,COG0657@2|Bacteria,1UZ7B@1239|Firmicutes,25B2C@186801|Clostridia 186801|Clostridia I Psort location Cytoplasmic, score - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 KKPNOBBG_05127 33035.JPJF01000073_gene4412 2.46e-276 758.0 COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3XZ6F@572511|Blautia 186801|Clostridia S Psort location - - - - - - - - - - - - AATase KKPNOBBG_05128 33035.JPJF01000073_gene4411 9.14e-148 418.0 2EFH0@1|root,2ZA40@2|Bacteria,1V0W1@1239|Firmicutes,24BY4@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05129 33035.JPJF01000073_gene4410 3.81e-287 790.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSRP@1239|Firmicutes,24CRG@186801|Clostridia 186801|Clostridia T response regulator - - - - - - - - - - - - HTH_18,Response_reg KKPNOBBG_05130 33035.JPJF01000092_gene282 9.63e-199 566.0 COG2972@1|root,COG2972@2|Bacteria,1UYCU@1239|Firmicutes,24A6J@186801|Clostridia 186801|Clostridia T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase KKPNOBBG_05131 33035.JPJF01000092_gene283 0.0 996.0 COG1653@1|root,COG1653@2|Bacteria,1TQ1D@1239|Firmicutes,24AFW@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K17318 ko02010,map02010 M00603 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.29,3.A.1.1.9 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_05132 33035.JPJF01000092_gene284 1.08e-180 504.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,3Y023@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05133 33035.JPJF01000092_gene285 1.07e-212 588.0 COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia,3Y17Y@572511|Blautia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05134 33035.JPJF01000092_gene286 0.0 877.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,3Y0CH@572511|Blautia 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_05135 33035.JPJF01000092_gene287 9.66e-290 793.0 COG2211@1|root,COG2211@2|Bacteria,1URUG@1239|Firmicutes,248SK@186801|Clostridia 186801|Clostridia G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 KKPNOBBG_05136 642492.Clole_3151 7.65e-101 302.0 COG2207@1|root,COG2207@2|Bacteria,1TR4U@1239|Firmicutes,24JVF@186801|Clostridia 186801|Clostridia K Transcriptional regulator - - - ko:K02099 - - - - ko00000,ko03000 - - - HTH_18 KKPNOBBG_05137 515620.EUBELI_20530 7.51e-188 537.0 COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,25VAF@186806|Eubacteriaceae 186801|Clostridia G ABC-type sugar transport system periplasmic component - - - - - - - - - - - - SBP_bac_8 KKPNOBBG_05138 1304866.K413DRAFT_0361 2.55e-145 418.0 COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia,36H73@31979|Clostridiaceae 186801|Clostridia G PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05139 1410626.JHXB01000016_gene1729 9.41e-124 361.0 COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,27IM4@186928|unclassified Lachnospiraceae 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05140 180332.JTGN01000009_gene4236 1.6e-115 341.0 COG3507@1|root,COG3507@2|Bacteria,1UYIB@1239|Firmicutes,24975@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 KKPNOBBG_05141 33035.JPJF01000037_gene2997 3.82e-214 592.0 COG2207@1|root,COG2207@2|Bacteria,1V062@1239|Firmicutes,25B1G@186801|Clostridia,3XZV3@572511|Blautia 186801|Clostridia K Cupin domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05142 33035.JPJF01000037_gene2998 9.14e-302 823.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,3XZFW@572511|Blautia 186801|Clostridia G Galactokinase galactose-binding signature galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg KKPNOBBG_05143 33035.JPJF01000037_gene2999 7.45e-218 603.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UYG6@1239|Firmicutes,24JEP@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05144 1232453.BAIF02000067_gene2013 2.44e-45 162.0 COG2207@1|root,COG2207@2|Bacteria,1TSRS@1239|Firmicutes,24BXX@186801|Clostridia 186801|Clostridia K transcriptional regulator (AraC family) - - - - - - - - - - - - AraC_binding,Cupin_2,HTH_18,HTH_AraC KKPNOBBG_05145 556261.HMPREF0240_03046 4.54e-126 371.0 COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia,36EEG@31979|Clostridiaceae 186801|Clostridia H Uroporphyrinogen decarboxylase (URO-D) hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,URO-D KKPNOBBG_05146 935845.JADQ01000019_gene4214 3.62e-51 192.0 COG2972@1|root,COG2972@2|Bacteria,1UZMM@1239|Firmicutes,4HGBU@91061|Bacilli,26SEP@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase - - 2.7.13.3 ko:K07718 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,His_kinase,dCache_1 KKPNOBBG_05147 658086.HMPREF0994_02106 3.89e-54 198.0 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia,27IEC@186928|unclassified Lachnospiraceae 186801|Clostridia T helix_turn_helix, arabinose operon control protein - - - ko:K07720 ko02020,map02020 M00519 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_18,HTH_AraC,Response_reg KKPNOBBG_05148 1121929.KB898662_gene422 1.61e-96 304.0 COG1653@1|root,COG1653@2|Bacteria,1TRIH@1239|Firmicutes,4HA29@91061|Bacilli 91061|Bacilli G solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_05149 428125.CLOLEP_02796 1.19e-92 282.0 COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,3WKCR@541000|Ruminococcaceae 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05150 525904.Tter_2701 2.02e-79 248.0 COG0395@1|root,COG0395@2|Bacteria,2NR1D@2323|unclassified Bacteria 2|Bacteria U Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05151 5465.ENH83266 3.94e-91 293.0 COG2730@1|root,2RDG8@2759|Eukaryota,394NW@33154|Opisthokonta,3NVK2@4751|Fungi,3QNTZ@4890|Ascomycota,218EI@147550|Sordariomycetes,1EU1M@1028384|Glomerellales 4751|Fungi G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase KKPNOBBG_05152 1235798.C817_02825 0.0 930.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia 186801|Clostridia G family 4 - - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_05153 33035.JPJF01000141_gene2440 1.23e-194 540.0 COG0726@1|root,COG0726@2|Bacteria,1TT1X@1239|Firmicutes,249PF@186801|Clostridia,3XZPS@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score pdaA - - ko:K01567 - - - - ko00000,ko01000 - - - Polysacc_deac_1 KKPNOBBG_05154 33035.JPJF01000009_gene1457 4.07e-239 662.0 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,247ME@186801|Clostridia,3Y0PJ@572511|Blautia 186801|Clostridia L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 KKPNOBBG_05155 33035.JPJF01000141_gene2443 2.79e-173 485.0 COG0561@1|root,COG0561@2|Bacteria,1V1JB@1239|Firmicutes,24AY8@186801|Clostridia,3Y059@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Hydrolase_3 KKPNOBBG_05156 33035.JPJF01000141_gene2444 2.39e-315 860.0 COG1653@1|root,COG1653@2|Bacteria,1TR5H@1239|Firmicutes,24977@186801|Clostridia 186801|Clostridia G PFAM extracellular solute-binding protein family 1 - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 KKPNOBBG_05157 33035.JPJF01000141_gene2445 5.98e-203 562.0 COG1175@1|root,COG1175@2|Bacteria,1TRU7@1239|Firmicutes,24AIC@186801|Clostridia,3XYIT@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02025,ko:K05814,ko:K17316 ko02010,map02010 M00198,M00207,M00605 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.24,3.A.1.1.3,3.A.1.1.30 - - BPD_transp_1 KKPNOBBG_05158 33035.JPJF01000141_gene2446 2.13e-194 540.0 COG0395@1|root,COG0395@2|Bacteria,1TPRG@1239|Firmicutes,249ZC@186801|Clostridia,3Y2EE@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05159 33035.JPJF01000141_gene2447 7.64e-217 602.0 COG0673@1|root,COG0673@2|Bacteria,1V0BK@1239|Firmicutes 1239|Firmicutes S oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C,ox_reductase_C KKPNOBBG_05160 33035.JPJF01000141_gene2448 6.49e-229 632.0 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase - - - - - - - - - - - - ADH_zinc_N KKPNOBBG_05161 33035.JPJF01000141_gene2449 3.03e-181 506.0 COG4977@1|root,COG4977@2|Bacteria,1VVMD@1239|Firmicutes 1239|Firmicutes K AraC-like ligand binding domain - - - - - - - - - - - - HTH_18 KKPNOBBG_05162 33035.JPJF01000141_gene2450 4.65e-180 503.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes,24BNN@186801|Clostridia,3XZEN@572511|Blautia 186801|Clostridia K Psort location Cytoplasmic, score - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05163 33035.JPJF01000141_gene2451 0.0 884.0 COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,3Y1J8@572511|Blautia 186801|Clostridia G Family 4 glycosyl hydrolase - - 3.2.1.22 ko:K07406 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Glyco_hydro_4,Glyco_hydro_4C KKPNOBBG_05164 272563.CD630_16510 3.61e-235 671.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia 186801|Clostridia T GGDEF domain - - - - - - - - - - - - EAL,GGDEF KKPNOBBG_05165 33035.JPJF01000141_gene2452 3.21e-41 136.0 2E45D@1|root,32Z1F@2|Bacteria,1VEXR@1239|Firmicutes,24R89@186801|Clostridia,3Y0W2@572511|Blautia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05166 33035.JPJF01000117_gene2823 7.39e-274 750.0 COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,3Y1B3@572511|Blautia 186801|Clostridia E Cys/Met metabolism PLP-dependent enzyme patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 KKPNOBBG_05167 33035.JPJF01000117_gene2824 9.64e-187 520.0 COG0546@1|root,COG0546@2|Bacteria,1V1RB@1239|Firmicutes,2487B@186801|Clostridia 186801|Clostridia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 KKPNOBBG_05168 33035.JPJF01000117_gene2825 0.0 1035.0 COG0510@1|root,COG4750@1|root,COG0510@2|Bacteria,COG4750@2|Bacteria,1TRCJ@1239|Firmicutes,24BS7@186801|Clostridia,3Y18T@572511|Blautia 186801|Clostridia M Choline/ethanolamine kinase - - - - - - - - - - - - Choline_kinase,HTH_24,NTP_transf_3,NTP_transferase KKPNOBBG_05169 33035.JPJF01000117_gene2826 4.74e-191 533.0 COG4750@1|root,COG4750@2|Bacteria,1TRCJ@1239|Firmicutes,24BS7@186801|Clostridia 186801|Clostridia M Psort location Cytoplasmic, score - - - - - - - - - - - - APH,Aminotran_1_2,Choline_kinase,HTH_24,NTP_transf_3 KKPNOBBG_05170 33035.JPJF01000117_gene2827 6.95e-212 587.0 COG0697@1|root,COG0697@2|Bacteria,1UYTR@1239|Firmicutes,249JF@186801|Clostridia 186801|Clostridia EG PFAM EamA-like transporter family - - - - - - - - - - - - EamA KKPNOBBG_05171 33035.JPJF01000117_gene2828 2.29e-119 342.0 COG2002@1|root,COG2002@2|Bacteria,1V02A@1239|Firmicutes,248XR@186801|Clostridia,3XZW9@572511|Blautia 186801|Clostridia K COG COG2002 Regulators of stationary sporulation gene expression spoVT - - ko:K04769 - - - - ko00000,ko03000 - - - MazE_antitoxin,SpoVT_C KKPNOBBG_05172 33035.JPJF01000117_gene2829 0.0 918.0 COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,3XZKK@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase,QRPTase_C,QRPTase_N KKPNOBBG_05173 33035.JPJF01000117_gene2830 3.3e-105 306.0 COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,24E6R@186801|Clostridia,3Y0AD@572511|Blautia 186801|Clostridia M D-alanyl-D-alanine carboxypeptidase - - 3.4.17.14 ko:K07260 ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020 M00651 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 - - - VanY KKPNOBBG_05174 33035.JPJF01000117_gene2831 0.0 1276.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia 186801|Clostridia T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg KKPNOBBG_05175 33035.JPJF01000117_gene2832 1.56e-178 499.0 COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,25CE3@186801|Clostridia,3XZYV@572511|Blautia 186801|Clostridia K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS KKPNOBBG_05176 33035.JPJF01000117_gene2833 1.04e-245 675.0 COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B2J@186801|Clostridia,3XZKP@572511|Blautia 186801|Clostridia E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N KKPNOBBG_05177 33035.JPJF01000117_gene2834 2.49e-204 565.0 COG1830@1|root,COG1830@2|Bacteria,1TR4S@1239|Firmicutes,24CYU@186801|Clostridia,3XYSF@572511|Blautia 186801|Clostridia G DeoC/LacD family aldolase - - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC KKPNOBBG_05178 33035.JPJF01000117_gene2835 0.0 975.0 COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3XZDA@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N KKPNOBBG_05179 33035.JPJF01000117_gene2836 6.84e-225 622.0 COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24C83@186801|Clostridia,3Y0JY@572511|Blautia 186801|Clostridia G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP KKPNOBBG_05180 33035.JPJF01000117_gene2837 2.56e-111 321.0 COG3090@1|root,COG3090@2|Bacteria,1V6K0@1239|Firmicutes,24K3G@186801|Clostridia,3Y19Y@572511|Blautia 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ KKPNOBBG_05181 537007.BLAHAN_05143 1.56e-254 704.0 COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,3XZAD@572511|Blautia 186801|Clostridia G Psort location CytoplasmicMembrane, score 9.99 - - - - - - - - - - - - DctM KKPNOBBG_05182 33035.JPJF01000076_gene5056 2.21e-226 624.0 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3Y1AB@572511|Blautia 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain hprA - 1.1.1.29 ko:K00018 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200 M00346 R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C KKPNOBBG_05183 33035.JPJF01000076_gene5057 5.69e-298 816.0 COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,3XYYG@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 9.98 pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI KKPNOBBG_05185 33035.JPJF01000076_gene5058 1.28e-166 466.0 COG3884@1|root,COG3884@2|Bacteria,1TRH5@1239|Firmicutes,24G5K@186801|Clostridia,3XZPR@572511|Blautia 186801|Clostridia I Psort location Cytoplasmic, score 8.87 - - 3.1.2.21 ko:K01071 ko00061,ko01100,map00061,map01100 - R04014,R08157,R08158 RC00014,RC00039 ko00000,ko00001,ko01000,ko01004 - - - Acyl-ACP_TE KKPNOBBG_05186 33035.JPJF01000076_gene5059 8.93e-186 518.0 COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia,3XZD5@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 cvfB - - ko:K00243 - - - - ko00000 - - - S1,S1_2 KKPNOBBG_05187 33035.JPJF01000076_gene5060 1.23e-121 349.0 COG0500@1|root,COG0500@2|Bacteria,1UI1D@1239|Firmicutes,25EAD@186801|Clostridia,3Y0F8@572511|Blautia 186801|Clostridia Q Tellurite resistance protein TehB - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,NUDIX KKPNOBBG_05188 33035.JPJF01000076_gene5061 0.0 2176.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,3XZJ6@572511|Blautia 186801|Clostridia L Psort location Cytoplasmic, score 9.98 dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon KKPNOBBG_05189 33035.JPJF01000076_gene5062 2.62e-237 652.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,3XYH6@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK KKPNOBBG_05190 33035.JPJF01000076_gene5063 4.75e-305 835.0 COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,3XZ2Q@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH KKPNOBBG_05191 33035.JPJF01000076_gene5064 4.12e-149 420.0 COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,3XZZU@572511|Blautia 186801|Clostridia P Psort location Cytoplasmic, score 8.87 - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N KKPNOBBG_05192 33035.JPJF01000076_gene5065 9.28e-161 454.0 COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3XYZF@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 8.87 spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind KKPNOBBG_05193 33035.JPJF01000076_gene5066 1.01e-138 402.0 COG3773@1|root,COG3773@2|Bacteria,1V6F0@1239|Firmicutes,25B2E@186801|Clostridia,3Y0E4@572511|Blautia 186801|Clostridia M Bacterial SH3 domain - - 3.5.1.28 ko:K01449 - - R04112 RC00064,RC00141 ko00000,ko01000 - - - Hydrolase_2,SH3_3 KKPNOBBG_05194 33035.JPJF01000076_gene5067 1.56e-144 410.0 COG0745@1|root,COG0745@2|Bacteria,1TSNV@1239|Firmicutes,2493A@186801|Clostridia,3Y04C@572511|Blautia 186801|Clostridia KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_05195 33035.JPJF01000076_gene5068 7.1e-166 469.0 COG0642@1|root,COG2205@2|Bacteria,1TR7T@1239|Firmicutes,24CJ8@186801|Clostridia,3XZXT@572511|Blautia 186801|Clostridia T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_05196 33035.JPJF01000076_gene5069 9.67e-294 806.0 COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,3XZ77@572511|Blautia 186801|Clostridia S Psort location CytoplasmicMembrane, score 9.99 pbuG - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease KKPNOBBG_05197 33035.JPJF01000076_gene5070 1.54e-147 417.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XZQT@572511|Blautia 186801|Clostridia V Psort location CytoplasmicMembrane, score 9.49 - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05198 33035.JPJF01000076_gene5071 0.0 1440.0 COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,248SQ@186801|Clostridia,3Y0XZ@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_05199 33035.JPJF01000076_gene5072 8.14e-86 254.0 COG1585@1|root,COG1585@2|Bacteria,1VAS9@1239|Firmicutes,24MRQ@186801|Clostridia,3Y0IA@572511|Blautia 186801|Clostridia OU Psort location CytoplasmicMembrane, score 9.26 - - - - - - - - - - - - NfeD KKPNOBBG_05200 33035.JPJF01000076_gene5073 2.18e-140 405.0 COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,3XZEQ@572511|Blautia 186801|Clostridia O SPFH Band 7 PHB domain protein qmcA - - - - - - - - - - - Band_7 KKPNOBBG_05201 33035.JPJF01000076_gene5074 2.45e-269 738.0 COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,3XZ6Q@572511|Blautia 186801|Clostridia S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin KKPNOBBG_05202 33035.JPJF01000076_gene5075 3.03e-230 634.0 COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3XYMZ@572511|Blautia 186801|Clostridia E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N KKPNOBBG_05203 33035.JPJF01000076_gene5076 2.39e-159 449.0 COG0340@1|root,COG0340@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,3XZNZ@572511|Blautia 186801|Clostridia H Biotin-- acetyl-CoA-carboxylase ligase birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 KKPNOBBG_05204 33035.JPJF01000020_gene3425 2.59e-68 207.0 2CJXG@1|root,32SB0@2|Bacteria,1VAFJ@1239|Firmicutes,24MNI@186801|Clostridia,3Y06J@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_05205 33035.JPJF01000020_gene3426 1.43e-177 495.0 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,3XZ5H@572511|Blautia 186801|Clostridia H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase KKPNOBBG_05206 33035.JPJF01000020_gene3427 5.3e-214 592.0 COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,3XZC5@572511|Blautia 186801|Clostridia H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus KKPNOBBG_05207 33035.JPJF01000020_gene3428 5.57e-99 288.0 COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,3XZTG@572511|Blautia 186801|Clostridia K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N KKPNOBBG_05208 33035.JPJF01000020_gene3429 0.0 963.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,3XZC3@572511|Blautia 186801|Clostridia J Psort location Cytoplasmic, score 10.00 lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind KKPNOBBG_05209 742733.HMPREF9469_03082 3.32e-25 94.4 2EJ02@1|root,33CR7@2|Bacteria,1VPEQ@1239|Firmicutes,24WQH@186801|Clostridia,223KR@1506553|Lachnoclostridium 186801|Clostridia S Arc-like DNA binding domain - - - - - - - - - - - - Arc KKPNOBBG_05210 97139.C824_04198 4.35e-38 134.0 2EV86@1|root,33NNV@2|Bacteria,1VMZG@1239|Firmicutes,24TGH@186801|Clostridia,36TZ0@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05211 742733.HMPREF9469_03083 5.76e-66 209.0 2EV86@1|root,33NNV@2|Bacteria,1VMZG@1239|Firmicutes,24X61@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05212 515620.EUBELI_20209 7.09e-119 340.0 28NU7@1|root,2ZBSM@2|Bacteria,1V2N8@1239|Firmicutes,24G4F@186801|Clostridia,25VQU@186806|Eubacteriaceae 186801|Clostridia S NOG32933 non supervised orthologous group - - - - - - - - - - - - - KKPNOBBG_05213 742733.HMPREF9469_03085 9.42e-108 316.0 COG1396@1|root,COG1396@2|Bacteria,1VM51@1239|Firmicutes,24FE9@186801|Clostridia 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_05214 411470.RUMGNA_03135 3.14e-62 193.0 2CE0F@1|root,33VDC@2|Bacteria,1VUJY@1239|Firmicutes,2509T@186801|Clostridia,3Y1PY@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - KKPNOBBG_05215 411461.DORFOR_02987 2.54e-186 526.0 COG2946@1|root,COG2946@2|Bacteria,1TST2@1239|Firmicutes 2|Bacteria L Psort location Cytoplasmic, score 8.87 - - - ko:K07467 - - - - ko00000 - - - HTH_3,Rep_trans KKPNOBBG_05216 658088.HMPREF0987_01877 3.3e-31 110.0 2E38H@1|root,32Y87@2|Bacteria,1VIF1@1239|Firmicutes,24RTS@186801|Clostridia,27Q0I@186928|unclassified Lachnospiraceae 186801|Clostridia S Excisionase from transposon Tn916 - - - - - - - - - - - - Tn916-Xis KKPNOBBG_05217 1408306.JHXX01000005_gene1147 7.66e-217 608.0 COG0582@1|root,COG0582@2|Bacteria,1TPCB@1239|Firmicutes,2485Y@186801|Clostridia,4BXJ9@830|Butyrivibrio 186801|Clostridia L Phage integrase family - - - - - - - - - - - - Integrase_DNA,Phage_int_SAM_3,Phage_integrase KKPNOBBG_05218 553973.CLOHYLEM_05950 1.35e-82 263.0 COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,21XUT@1506553|Lachnoclostridium 186801|Clostridia J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon,tRNA_bind KKPNOBBG_05219 742723.HMPREF9477_01391 3.77e-115 332.0 COG5340@1|root,COG5340@2|Bacteria,1TQSK@1239|Firmicutes,247JC@186801|Clostridia,27MPR@186928|unclassified Lachnospiraceae 186801|Clostridia K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - AbiEi_4 KKPNOBBG_05220 552396.HMPREF0863_02469 9.81e-26 102.0 COG2253@1|root,COG2253@2|Bacteria,1TSFX@1239|Firmicutes 1239|Firmicutes S Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEii KKPNOBBG_05221 1519439.JPJG01000110_gene2365 9.64e-82 251.0 COG2253@1|root,COG2253@2|Bacteria,1TSFX@1239|Firmicutes,24C3A@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - AbiEii KKPNOBBG_05222 33035.JPJF01000014_gene4755 1.89e-155 438.0 COG1402@1|root,COG1402@2|Bacteria,1TUPT@1239|Firmicutes,259JU@186801|Clostridia,3Y23Z@572511|Blautia 186801|Clostridia S Creatinine amidohydrolase - - - - - - - - - - - - Creatininase KKPNOBBG_05223 33035.JPJF01000014_gene4754 0.0 918.0 COG3669@1|root,COG3669@2|Bacteria,1TT4V@1239|Firmicutes,24A0S@186801|Clostridia 186801|Clostridia G PFAM glycoside hydrolase family 29 (alpha-L-fucosidase) - - 3.2.1.51 ko:K01206 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04147 - GH29 - Alpha_L_fucos,Fucosidase_C KKPNOBBG_05224 33035.JPJF01000014_gene4753 9.26e-139 399.0 COG2207@1|root,COG2207@2|Bacteria,1UI06@1239|Firmicutes,250WD@186801|Clostridia 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05225 556261.HMPREF0240_01149 1.17e-108 318.0 COG0745@1|root,COG0745@2|Bacteria,1TT2Z@1239|Firmicutes,248PN@186801|Clostridia,36DR9@31979|Clostridiaceae 186801|Clostridia T response regulator, receiver - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_05226 1235798.C817_04364 3.06e-123 362.0 COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,247M8@186801|Clostridia 186801|Clostridia V ABC-type multidrug transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05227 1235798.C817_04365 2.67e-51 176.0 2DBS5@1|root,2ZAPZ@2|Bacteria,1TSG3@1239|Firmicutes,24C94@186801|Clostridia 186801|Clostridia S ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_4 KKPNOBBG_05228 556261.HMPREF0240_01146 1.36e-88 273.0 COG0642@1|root,COG0642@2|Bacteria,1UICA@1239|Firmicutes,25EHC@186801|Clostridia,36UQG@31979|Clostridiaceae 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_05229 33035.JPJF01000014_gene4752 0.0 1170.0 COG4289@1|root,COG4289@2|Bacteria,1TSHI@1239|Firmicutes,249KM@186801|Clostridia 186801|Clostridia S Uncharacterized protein conserved in bacteria (DUF2264) - - - - - - - - - - - - DUF2264 KKPNOBBG_05230 645991.Sgly_2137 2.88e-157 447.0 COG2207@1|root,COG2207@2|Bacteria,1TQKE@1239|Firmicutes,24A8P@186801|Clostridia,262WN@186807|Peptococcaceae 186801|Clostridia K PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,HTH_18 KKPNOBBG_05231 33035.JPJF01000009_gene1417 9.37e-103 311.0 COG5464@1|root,COG5464@2|Bacteria,1TYQI@1239|Firmicutes,24D7J@186801|Clostridia,3Y26P@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - Transposase_31 KKPNOBBG_05232 33035.JPJF01000014_gene4745 2.33e-144 409.0 COG0745@1|root,COG0745@2|Bacteria,1TQRT@1239|Firmicutes,249PK@186801|Clostridia,3XZNU@572511|Blautia 186801|Clostridia T Response regulator receiver domain - - - - - - - - - - - - Response_reg,Trans_reg_C KKPNOBBG_05233 33035.JPJF01000014_gene4744 8.72e-168 474.0 COG0642@1|root,COG2205@2|Bacteria,1TT7F@1239|Firmicutes,247UJ@186801|Clostridia 186801|Clostridia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA KKPNOBBG_05234 33035.JPJF01000014_gene4743 7.29e-146 412.0 COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,247JJ@186801|Clostridia,3XYM9@572511|Blautia 186801|Clostridia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran KKPNOBBG_05235 33035.JPJF01000014_gene4742 0.0 1280.0 COG0577@1|root,COG0577@2|Bacteria,1TRAS@1239|Firmicutes,248SQ@186801|Clostridia,3Y0XZ@572511|Blautia 186801|Clostridia V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX KKPNOBBG_05237 33035.JPJF01000014_gene4740 2.77e-181 506.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UUUQ@1239|Firmicutes,25KCM@186801|Clostridia,3Y1UF@572511|Blautia 186801|Clostridia K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_18 KKPNOBBG_05238 33035.JPJF01000014_gene4738 9.02e-311 848.0 COG1807@1|root,COG1807@2|Bacteria,1V22V@1239|Firmicutes,24GKH@186801|Clostridia,3XYRT@572511|Blautia 186801|Clostridia M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 KKPNOBBG_05240 33035.JPJF01000014_gene4736 9.64e-263 721.0 COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia 186801|Clostridia Q amidohydrolase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 KKPNOBBG_05241 33035.JPJF01000014_gene4735 3.4e-145 412.0 COG4126@1|root,COG4126@2|Bacteria,1TT35@1239|Firmicutes,24KAI@186801|Clostridia,3Y0DR@572511|Blautia 186801|Clostridia E AroM protein - - - ko:K14591 - - - - ko00000 - - - AroM KKPNOBBG_05242 33035.JPJF01000014_gene4734 5.28e-210 582.0 arCOG05881@1|root,2Z800@2|Bacteria,1TS9C@1239|Firmicutes,24CDW@186801|Clostridia,3XZMR@572511|Blautia 186801|Clostridia S Protein of unknown function (DUF1177) - - - - - - - - - - - - DUF1177 KKPNOBBG_05243 33035.JPJF01000014_gene4733 0.0 1056.0 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,3Y0CE@572511|Blautia 186801|Clostridia E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 KKPNOBBG_05244 33035.JPJF01000014_gene4732 4.76e-205 569.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,3Y02S@572511|Blautia 186801|Clostridia EP Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 KKPNOBBG_05245 33035.JPJF01000014_gene4731 7.84e-191 532.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,3XZYG@572511|Blautia 186801|Clostridia EP N-terminal TM domain of oligopeptide transport permease C - - - - - - - - - - - - BPD_transp_1,OppC_N KKPNOBBG_05246 33035.JPJF01000014_gene4730 1.34e-279 764.0 COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,3XZGT@572511|Blautia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_05247 33035.JPJF01000014_gene4729 1.12e-246 677.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,3XZ1P@572511|Blautia 186801|Clostridia EP Psort location CytoplasmicMembrane, score 9.49 - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_05248 33035.JPJF01000014_gene4728 3.22e-227 626.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3XZ61@572511|Blautia 186801|Clostridia E Psort location CytoplasmicMembrane, score 9.49 - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY KKPNOBBG_05249 33035.JPJF01000014_gene4727 6.62e-296 808.0 COG0624@1|root,COG0624@2|Bacteria,1UY58@1239|Firmicutes,24FFH@186801|Clostridia,3Y1CB@572511|Blautia 186801|Clostridia E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 KKPNOBBG_05250 33035.JPJF01000010_gene1235 3.67e-194 540.0 COG2207@1|root,COG2207@2|Bacteria,1V293@1239|Firmicutes 1239|Firmicutes K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 KKPNOBBG_05251 33035.JPJF01000010_gene1236 8.49e-105 302.0 COG0346@1|root,COG0346@2|Bacteria,1V5GM@1239|Firmicutes,24RNN@186801|Clostridia 186801|Clostridia E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase_4 KKPNOBBG_05252 33035.JPJF01000010_gene1237 3.21e-302 829.0 COG2182@1|root,COG2182@2|Bacteria,1TT4I@1239|Firmicutes,249TR@186801|Clostridia 186801|Clostridia G Bacterial extracellular solute-binding protein - - - - - - - - - - - - SBP_bac_1 KKPNOBBG_05253 33035.JPJF01000010_gene1238 4.2e-183 511.0 COG0395@1|root,COG0395@2|Bacteria,1TSAB@1239|Firmicutes,249PI@186801|Clostridia,3Y0AX@572511|Blautia 186801|Clostridia G Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 KKPNOBBG_05254 33035.JPJF01000010_gene1239 5.26e-202 560.0 COG1175@1|root,COG1175@2|Bacteria,1V180@1239|Firmicutes,25C4R@186801|Clostridia 186801|Clostridia P Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05255 33035.JPJF01000010_gene1240 3.38e-148 420.0 COG4221@1|root,COG4221@2|Bacteria,1UHZY@1239|Firmicutes,24P08@186801|Clostridia 186801|Clostridia S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short KKPNOBBG_05256 33035.JPJF01000010_gene1241 1.34e-258 711.0 COG0673@1|root,COG0673@2|Bacteria,1U4A4@1239|Firmicutes,249UF@186801|Clostridia 186801|Clostridia E PFAM oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA KKPNOBBG_05257 33035.JPJF01000010_gene1242 2.22e-112 322.0 COG0346@1|root,COG0346@2|Bacteria,1V5GM@1239|Firmicutes,24GNP@186801|Clostridia 186801|Clostridia E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase_4 KKPNOBBG_05258 33035.JPJF01000010_gene1243 3.14e-190 529.0 COG1082@1|root,COG1082@2|Bacteria,1V08R@1239|Firmicutes,24C9W@186801|Clostridia 186801|Clostridia G PFAM Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 KKPNOBBG_05259 33035.JPJF01000010_gene1244 0.0 910.0 COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,3Y00Y@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1,PMI_typeI KKPNOBBG_05260 33035.JPJF01000010_gene1245 4.03e-261 726.0 COG1073@1|root,COG1073@2|Bacteria,1TSFY@1239|Firmicutes,24ETS@186801|Clostridia 186801|Clostridia M COG1073 Hydrolases of the alpha beta superfamily - - - ko:K06889 - - - - ko00000 - - - CW_binding_2,Cu_amine_oxidN1,DLH,DUF3887,Hydrolase_4,Peptidase_S9 KKPNOBBG_05261 33035.JPJF01000010_gene1248 9.19e-217 605.0 COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,3XZGW@572511|Blautia 186801|Clostridia C Radical SAM superfamily - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM KKPNOBBG_05262 33035.JPJF01000010_gene1249 8.28e-127 362.0 COG1309@1|root,COG1309@2|Bacteria,1V1ZJ@1239|Firmicutes,24FQ3@186801|Clostridia,3Y20D@572511|Blautia 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N KKPNOBBG_05263 457421.CBFG_01650 1.49e-122 355.0 COG3910@1|root,COG3910@2|Bacteria,1TSWP@1239|Firmicutes,249W3@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score - - - - - - - - - - - - AAA_15,AAA_21,AAA_23 KKPNOBBG_05264 33035.JPJF01000010_gene1250 3.01e-178 508.0 COG1994@1|root,COG1994@2|Bacteria,1V3Y3@1239|Firmicutes,24C6G@186801|Clostridia 186801|Clostridia S Peptidase M50 - - - - - - - - - - - - Peptidase_M50 KKPNOBBG_05265 33035.JPJF01000010_gene1251 4.25e-55 173.0 COG4828@1|root,COG4828@2|Bacteria,1VACG@1239|Firmicutes,24JWS@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1622) - - - - - - - - - - - - DUF1622 KKPNOBBG_05266 658086.HMPREF0994_06015 2.58e-65 212.0 COG2207@1|root,COG2207@2|Bacteria,1V0Z0@1239|Firmicutes 1239|Firmicutes K AraC family - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC KKPNOBBG_05267 1449338.JQLU01000005_gene1504 3.71e-162 469.0 COG1653@1|root,COG1653@2|Bacteria,1UWS1@1239|Firmicutes,4I336@91061|Bacilli,27HT9@186828|Carnobacteriaceae 91061|Bacilli G Bacterial extracellular solute-binding protein - - - - - - - - - - - - - KKPNOBBG_05268 1449338.JQLU01000005_gene1503 1.18e-135 392.0 COG1175@1|root,COG1175@2|Bacteria,1TREE@1239|Firmicutes,4HBEF@91061|Bacilli,27FZI@186828|Carnobacteriaceae 91061|Bacilli G Binding-protein-dependent transport system inner membrane component - - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05269 1121115.AXVN01000014_gene1228 6.94e-28 115.0 COG0491@1|root,COG0491@2|Bacteria,1V3ZB@1239|Firmicutes,25BG4@186801|Clostridia 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B KKPNOBBG_05270 1552123.EP57_12330 1.34e-128 373.0 COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,26KR6@186820|Listeriaceae 91061|Bacilli G ABC transporter (permease) - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 KKPNOBBG_05271 33035.JPJF01000010_gene1252 2.44e-36 123.0 COG0690@1|root,COG0690@2|Bacteria,1VH7Y@1239|Firmicutes,24RJ1@186801|Clostridia,3Y0SS@572511|Blautia 186801|Clostridia U SecE/Sec61-gamma subunits of protein translocation complex secE - - ko:K03073 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecE KKPNOBBG_05272 33035.JPJF01000010_gene1253 2.73e-118 338.0 COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,3XZ8Y@572511|Blautia 186801|Clostridia K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG KKPNOBBG_05273 33035.JPJF01000010_gene1254 5.65e-92 269.0 COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,3XZUC@572511|Blautia 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N KKPNOBBG_05274 33035.JPJF01000010_gene1255 1.62e-160 450.0 COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3XZIY@572511|Blautia 186801|Clostridia J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 KKPNOBBG_05275 33035.JPJF01000010_gene1261 0.0 1001.0 COG3290@1|root,COG5002@1|root,COG3290@2|Bacteria,COG5002@2|Bacteria,1VC62@1239|Firmicutes,25E8N@186801|Clostridia,3Y0QU@572511|Blautia 186801|Clostridia T GHKL domain - - - - - - - - - - - - HATPase_c_5 KKPNOBBG_05276 33035.JPJF01000010_gene1262 2.06e-219 635.0 2DQRX@1|root,338BJ@2|Bacteria,1VI3G@1239|Firmicutes,24SAD@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05277 33035.JPJF01000010_gene1263 1.16e-152 431.0 COG3279@1|root,COG3279@2|Bacteria,1VA5A@1239|Firmicutes,24DB9@186801|Clostridia,3Y0I2@572511|Blautia 186801|Clostridia KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg KKPNOBBG_05278 33035.JPJF01000010_gene1264 3.69e-168 474.0 COG4974@1|root,COG4974@2|Bacteria,1TY7M@1239|Firmicutes,24BN9@186801|Clostridia 186801|Clostridia L Psort location Cytoplasmic, score - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase KKPNOBBG_05279 33035.JPJF01000013_gene4726 1.63e-31 112.0 2DTB6@1|root,33JI0@2|Bacteria,1VQRZ@1239|Firmicutes,24X41@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05280 33035.JPJF01000013_gene4725 1.28e-264 729.0 COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,3XYVZ@572511|Blautia 186801|Clostridia M Glycosyl hydrolases family 18 - - - ko:K06306 - - - - ko00000 - - - Glyco_hydro_18,LysM KKPNOBBG_05281 33035.JPJF01000013_gene4724 0.0 2188.0 COG1196@1|root,COG2931@1|root,COG1196@2|Bacteria,COG2931@2|Bacteria,1UI05@1239|Firmicutes 1239|Firmicutes Q Parallel beta-helix repeats - - - - - - - - - - - - - KKPNOBBG_05282 33035.JPJF01000013_gene4723 2.17e-129 381.0 28NJG@1|root,33CS1@2|Bacteria,1VKJX@1239|Firmicutes,24UHP@186801|Clostridia 186801|Clostridia - - - - 5.2.1.8 ko:K07533 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2 KKPNOBBG_05283 1123075.AUDP01000003_gene527 2.15e-75 229.0 2BBZW@1|root,325IG@2|Bacteria,1URJM@1239|Firmicutes,259FU@186801|Clostridia,3WQ3I@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05285 1123075.AUDP01000003_gene529 3.08e-65 204.0 2C6ZI@1|root,32VIE@2|Bacteria,1VBAJ@1239|Firmicutes,24Q9Q@186801|Clostridia,3WQB0@541000|Ruminococcaceae 186801|Clostridia - - - - - - - - - - - - - - - KKPNOBBG_05287 33035.JPJF01000013_gene4722 3.08e-108 312.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3XZVD@572511|Blautia 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 KKPNOBBG_05288 33035.JPJF01000013_gene4721 2.14e-63 196.0 COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,3XZZA@572511|Blautia 186801|Clostridia J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N KKPNOBBG_05289 1216932.CM240_0499 1.41e-89 265.0 COG1396@1|root,COG1396@2|Bacteria,1VA98@1239|Firmicutes,24A4S@186801|Clostridia,36M7R@31979|Clostridiaceae 186801|Clostridia K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 KKPNOBBG_05290 33035.JPJF01000013_gene4708 4.41e-308 844.0 COG1757@1|root,COG1757@2|Bacteria,1TQPI@1239|Firmicutes,2495U@186801|Clostridia,3Y1HZ@572511|Blautia 186801|Clostridia C Na H antiporter - - - - - - - - - - - - Na_H_antiporter KKPNOBBG_05291 33035.JPJF01000013_gene4707 1.22e-272 746.0 COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3XZ6G@572511|Blautia 186801|Clostridia C Psort location Cytoplasmic, score trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3,Thioredoxin KKPNOBBG_05292 33035.JPJF01000013_gene4706 0.0 1266.0 COG0526@1|root,COG0526@2|Bacteria,1TRBZ@1239|Firmicutes,249GQ@186801|Clostridia 186801|Clostridia CO PFAM Arylsulfotransferase (ASST) - - - - - - - - - - - - Arylsulfotran_2,Arylsulfotrans,Thioredoxin KKPNOBBG_05293 33035.JPJF01000013_gene4705 3.38e-149 421.0 COG0664@1|root,COG0664@2|Bacteria,1V575@1239|Firmicutes,24H9V@186801|Clostridia 186801|Clostridia K Cyclic nucleotide-binding domain protein - - - - - - - - - - - - HTH_Crp_2,cNMP_binding KKPNOBBG_05294 33035.JPJF01000013_gene4704 0.0 2493.0 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,3XYKN@572511|Blautia 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 KKPNOBBG_05295 33035.JPJF01000013_gene4703 0.0 2326.0 COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,3XYSW@572511|Blautia 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 KKPNOBBG_05296 33035.JPJF01000013_gene4702 5.93e-255 705.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3Y10V@572511|Blautia 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 KKPNOBBG_05297 33035.JPJF01000013_gene4701 2.72e-88 259.0 COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,3XZTZ@572511|Blautia 186801|Clostridia J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 KKPNOBBG_05298 33035.JPJF01000013_gene4700 1.15e-102 298.0 COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,3XYYV@572511|Blautia 186801|Clostridia J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG - - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 KKPNOBBG_05299 33035.JPJF01000013_gene4699 0.0 1360.0 COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,3XYNI@572511|Blautia 186801|Clostridia J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 KKPNOBBG_05300 33035.JPJF01000013_gene4698 4.21e-285 779.0 COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,3XZPV@572511|Blautia 186801|Clostridia J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 KKPNOBBG_05301 33035.JPJF01000013_gene4685 1.56e-11 62.4 COG1595@1|root,COG1595@2|Bacteria,1VACS@1239|Firmicutes,24KS7@186801|Clostridia,3Y07M@572511|Blautia 186801|Clostridia K RNA polymerase sigma-70 factor, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 KKPNOBBG_05302 33035.JPJF01000013_gene4683 7.14e-266 732.0 COG0477@1|root,COG2814@2|Bacteria,1UZ7N@1239|Firmicutes,25NTE@186801|Clostridia,3Y26K@572511|Blautia 186801|Clostridia EGP MFS_1 like family - - - - - - - - - - - - MFS_1_like KKPNOBBG_05303 33035.JPJF01000013_gene4682 4.59e-115 331.0 COG2191@1|root,COG2191@2|Bacteria,1UZ0V@1239|Firmicutes,24FX7@186801|Clostridia,3Y09I@572511|Blautia 186801|Clostridia C molybdenum containing formylmethanofuran dehydrogenase, subunit E K00199 - - 1.2.7.12 ko:K11261 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00567 R03015,R08060,R11743 RC00197,RC00323 ko00000,ko00001,ko00002,ko01000 - - - FmdE,zf-dskA_traR KKPNOBBG_05304 33035.JPJF01000013_gene4681 0.0 1094.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,3XYKH@572511|Blautia 186801|Clostridia L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_III,MutS_V,Smr KKPNOBBG_05305 1105031.HMPREF1141_2137 3.06e-71 219.0 COG3153@1|root,COG3153@2|Bacteria,1V3PW@1239|Firmicutes,24ACS@186801|Clostridia,36J99@31979|Clostridiaceae 186801|Clostridia K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 ## 4998 queries scanned ## Total time (seconds): 311.2778494358063 ## Rate: 16.06 q/s