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Overview
1.1
2.1
2.2

### Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaFCICFAKG_1 (original name was: gnl|Prokka|FCICFAKG_1)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS | 394,142 | 435,299 |

gnlProkkaFCICFAKG_2 (original name was: gnl|Prokka|FCICFAKG_2)

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii,RiPP-like | 67,868 | 90,810 |
Region 2.2 | arylpolyene | 136,250 | 166,020 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS | 394,142 | 435,299 |
Region 2.1 | lanthipeptide-class-ii,RiPP-like | 67,868 | 90,810 |
Region 2.2 | arylpolyene | 136,250 | 166,020 |

No secondary metabolite regions were found in these records:
  gnlProkkaFCICFAKG_3 (original name was: gnl|Prokka|FCICFAKG_3)
  gnlProkkaFCICFAKG_4 (original name was: gnl|Prokka|FCICFAKG_4)
  gnlProkkaFCICFAKG_5 (original name was: gnl|Prokka|FCICFAKG_5)
  gnlProkkaFCICFAKG_6 (original name was: gnl|Prokka|FCICFAKG_6)
  gnlProkkaFCICFAKG_7 (original name was: gnl|Prokka|FCICFAKG_7)

Compact view
gnlProkkaFCICFAKG_1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 394,142 - 435,299 nt. (total: 41,158 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

gnlProkkaFCICFAKG_2 - Region 1 - RiPP-like,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 67,868 - 90,810 nt. (total: 22,943 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
KnownClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for ctg2_81

ctg2_79
Leader:
MDKEELEKIVGNNFEEMSLQKMTEIQGM
Core:
G E Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R W C
Core with dehydrations:
G E Y Q V D Dha Dhb P A A Dha A I Dha R A Dhb I Q V Dha R A Dha Dha G K Cys L Dha W G Dha G A A F Dha A Y F Dhb H K R W Cys

#### antiSMASH-DB 4.0 matches for ctg2_79

33.3% NZ_CP045729.1: Lanthipeptides: LG045_RS07910_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C L S W
32
G S T P A I S R T+ ++R S S K C+S W
1
G T E T A Q S T P A---I S R V T L S I A R K S S A K C I S W
29
31.2% NZ_CP026035.1: Lanthipeptides: C2H96_RS00305_lanthipeptide
8
T P A A S A I S R A T I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R W C
48
T P A S A+ A + +R C+S G G+A S +H + C
8
T P A V S A V L S A V G R S T R L----C I S-G I G S A I S G I V S H N K D C
43
31.2% NZ_CP094446.1: Lanthipeptides: L3476_RS23825_lanthipeptide
2
E Y Q V D S T P A--A S A I S R A T I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R W C
48
+ + T P A S A++R S S C+S G+A S +H + C
2
D V E P R G T P A T I V S A V T R--------S S K P C I S-A I G S A I S G I I S H N K D C
41
with 15 more sequence matches
27.1% NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I Q V--S R A S S G K C L S
31
G+ ++T P A I A T I V S + K C S
1
G D V N P E T T P A T P T I I G A T I A V T A S L C P T T K C T S
33
27.1% NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I--Q V S R A S S G K C L S
31
G+ ++T P A I A T I V S + K C S
1
G D V N P E T T P A T P T I V E A T I A A T V S I C P T T K C T S
33
27.1% NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
18
T I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R W C
48
I V S R A S S C+S S A S ++ + C
11
V I V V S R A S S K A C M S G V S--A I S G L L S Y N K D C
39
27.1% NZ_KN125582.1: Lanthipeptides: DJ91_RS27550_lanthipeptide
19
I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R W C
48
I V S R S S K C S S A S ++ + C
12
I V V S R I S S A K C A S T I S--A I S G L V S Y N K D C
39
25.0% NZ_CP045729.1: Lanthipeptides: allorf_1568662_1568871_lanthipeptide
10
A A S A I S R A T I Q V S R A S S G K C L S W G S G A A F S A Y F T H K R
46
A S A + I +S+A S S +C W S + ++ H +
8
A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L S W A K H H K
44
22.9% NZ_CP099547.1: Lanthipeptides: allorf_0559994_0560212_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C L S W
32
G ++T P + S V S+A S G +S W
2
G G I T P N A T P T V T T S S V P C A T V S K A V S G A L V S W
33
20.8% NZ_NVMQ01000017.1: Lanthipeptides: CON32_RS17795_lanthipeptide
9
P A A S A I S R A T I Q V S R A S S G K C
29
P S R T+Q S+A S S C
9
P T V V V A S R I T V Q A S K A S S K S C
29
20.0% NZ_JAQCQD010000003.1: Lanthipeptides: PGZ38_RS05485_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C
29
G+ + T P A + I +R A S S C
1
G D M S A E L T P T T P A C F A S I I Y T A R A S S P N C
29
20.0% NZ_QSIO01000003.1: Lanthipeptides: DW820_RS07290_lanthipeptide
1
G E Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C
29
G+ + T P A + I +R A S S C
1
G D M S A E F T P T T P A C F A S I I Y T A R A S S A S C
29
18.8% NZ_FPCC01000026.1: Lanthipeptides: BM377_RS12935_lanthipeptide
1
G E Y Q V D S T P A A S A I S----------R A T I Q V S R A S S G K C
29
G+ ++T P A + + A T++V++ +G C
1
G D V D A E T T P A I T V S A A V V I G G S L G F E A T V K V T K T C N G N C
39
18.8% NZ_JADMPO010000001.1: Lanthipeptides: I2I27_RS01390_lanthipeptide
7
S T P--A A S A I S R A T I Q V S R A S S G K C
29
+T P A + + +I Q V++ G K C
8
T T P I C A V A V T A S L S I Q V A K T L K G K C
32
16.7% NZ_VTZW01000015.1: Lanthipeptides: allorf_204916_205050_lanthipeptide
32
W G S G A A F S A Y F T H
44
W G A F S Y F H
8
W E R G E A F S D Y F D H
20
16.2% NZ_MOWR01000001.1: Lanthipeptides: allorf_319458_319697_lanthipeptide
3
Y Q V D S T P A A S A I S R A T I Q V S R A S S G K C L S W G S G A A F S A
40
+Q ++T ++S R A V+ S C +W S + A
24
F Q T N N T----S V S R A F F A V T A T M S A A C Q N W S S Q K N Y P A
57
15.3% NZ_OAOR01000001.1 and 1 other:
NZ_OAOR01000001.1 Lanthipeptides: allorf_0316623_0316829_lanthipeptide
Lanthipeptides: allorf_0316623_0316829_lanthipeptide
28
K C L S W G S G A A F S A Y F T H
44
+C G G A A +A Y T H
32
R C F R S G M G A A Q A A Y R T H
48
12.5% NZ_SDJV01000024.1 and 1 other:
NZ_SDJV01000024.1 Lanthipeptides: ES032_RS12705_lanthipeptide
Lanthipeptides: ES032_RS12700_lanthipeptide
1
G E Y Q V D S T P A
10
G+ Q V++T P A
1
G D V Q V E T T P A
10
allorf_085809_085901
Leader:
MRVAHKQSPLAIDYDCQGA
Core:
L F V L V I L L C F T
Core with dehydrations:
L F V L V I L L Cys F Dhb

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

ctg2_79 - Class II
  Cleavage pHMM score: -2.10
  RODEO score: 0
  Monoisotopic mass: 4879.4 Da
  Molecular weight: 4882.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4900.4 Da N = 1
    4918.4 Da N = 2
    4936.4 Da N = 3
    4954.4 Da N = 4
    4972.5 Da N = 5
    4990.5 Da N = 6
    5008.5 Da N = 7
    5026.5 Da N = 8
    5044.5 Da N = 9
    5062.6 Da N = 10
allorf_085809_085901 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 1261.8 Da
  Molecular weight: 1262.6 Da
  Number of bridges: 1

gnlProkkaFCICFAKG_2 - Region 2 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 136,250 - 166,020 nt. (total: 29,771 nt) Show pHMM detection rules used
Region on contig edge.
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
NRPS/PKS domains
KnownClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 3.1
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

NRPS/PKS substrates
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg2_154: mal
  PKS_AT (5..284): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 66.7%
  minowa: inactive
  Prediction, score:
    inactive: 28.9
    Malonyl-CoA: 25.1
    Methoxymalonyl-CoA: 9.9
    trans-1,2-CPDA: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0