LOCUS       c00044_gnlPro..        10321 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NDGFIKAM_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 09:40:34
            Original ID  :: gnl|Prokka|NDGFIKAM_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10321
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10321
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3134:7994]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3135..7994
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..10321
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10321
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             51..614
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="MKISFSKQTKERTFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKLDTDSFDLQSNTALAYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPVYET
                     EPDSIYTLDELYRMLYETLNKLPENYRTVFIKSFFEGKTHTEIAKEMNLSVKSINRYKQ
                     KTMELLRNELKEYMPLLLLLFLRA"
     CDS             complement(884..2017)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 54.6; E-value:
                     2.4e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_2"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-18, bitscore:
                     54.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFDRQQQRLLLEGKEYTFEEISQLIAGGAEAHSPAYWDLYLFLN
                     EWFNDSPVITVHTSGSTGIPKELMVRKDQMMQSARLTCEFLNLKKGESALLCMNLRYIG
                     AMMVVVRSLVAGLNLIVRPASGHPLADIKEPLRFVAMVPLQVYNTMQVPEEKERLKQTD
                     ILIIGGGAVDEALETEINHLPTAVYSTYGMTETLSHIALRRLNGASASEHYYPFPSVKL
                     SLSAENTLIIDAPLVCDETLQTNDIARIYPDGSFMILGRKDNVINSGGIKIQAEEMEKL
                     LRPFIPVSFVITSVPDQRLGQAVTLLLADQPDTEEIGNKLHEILEPYYRPKHILTIESI
                     PQTENGKINRAECRILAKQMLMTFYPHTLTLSRPAPN"
     CDS             complement(2049..3074)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_3"
                     /sec_met_domain="MR_MLE_C (E-value: 3.6e-30, bitscore:
                     94.4, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDCKIDIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILIRTCRQVEEEQGKLDKDGLCKYPSILFGLETAIWHFF
                     AGSWALSDTAFSRGEVGIPINGLIWMGDFENMLSQIEKKMEAGFRCVKLKIGAIDFEKE
                     LALLRHIRTHFSSKEIELRVDANGAFSPGDAMEKLKRLSEFDLHSIEQPIRAGQWEEMA
                     RLTSESPLPVALDEELIGCNTLEEKKKLLATIRPQYIIIKPSLHGGICGGDEWIMEAEK
                     QHIGWWITSALESNIGLNAIAHWCATFNNPLPQGLGTGMLFTDNIEVPLEIRKDCLWFC
                     K"
     CDS             complement(3135..3959)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_4"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-79, bitscore: 255.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSITKPMIAAVNGFAIGGRHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             complement(3963..5630)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.7e-08, bitscore:
                     21.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYAVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVVISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDALPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKIDQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPEGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPDYPRVWENYCKIIPEPDFAYSEMLAVGTLLKALPESCALHLANSSVVRYAQLYSIP
                     SAIEVCCNRGTSGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNINVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELTEAM
                     KTFTQPETMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             complement(5650..6765)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_6"
                     /sec_met_domain="Chorismate_bind (E-value: 1.9e-57,
                     bitscore: 184.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSETCPVVLIQPDQWGQPLPIDNDTAEEREVALRMQGQES
                     FLTSSTEEYASCFHTFINALRDNTFDKLVLSRHLTIDKVSGFSPLSIFRAACRRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLGIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYRFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDEQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIATPPLKS"
     CDS             complement(6762..7994)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_7"
                     /sec_met_domain="HBT (E-value: 1.4e-18, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYNLFVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNDLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     LGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLGMKREEVIAVGDGV
                     CDVTMIQLAGLGIAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIISEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             complement(8078..8440)
                     /locus_tag="ctg44_8"
                     /transl_table=11
                     /translation="MIQVRIKRVYEDFSETDGYRVLVDKLWPRGMKKEWLKYDYWAKDI
                     TPSPTLRKWFHEDIPGHWGDFVTQYQKELDASPSMADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMRLRE"
     CDS             complement(8505..10262)
                     /locus_tag="ctg44_9"
                     /transl_table=11
                     /translation="MRFWVCIFVLLFVHNQFSRADKIINNDSLYTEKYIRDIYISNPKR
                     ALQLLDEAETRKAFPLRLINELRSLSYRNMYMNKLAFMYARKSYLLDSISQREPKHMLK
                     MTVYLAELSSIMSKYNESMHYALSGIMQAQKLKDREAEARLLFCIGENNWRLSLKDEAY
                     NYFGRTIELLRGSKDMRGMMLLSYYYGAEMGFLMTDSRIDEALALAYEREKLLKKLEKV
                     PEVPEGYIDGQYSYLYAKLAYISYLEKKYAQAEGYYQKYLAIKESHTPDGKMYSIPYLI
                     LSKQYETVIDNCKDFKELLRTQRDTLNAQYLTILNKEVQAYLGLNRYKEAAEIRETIIA
                     ITDSINSTDRKNAALELNAMYGASEKEEYIAEQASQLKIRNVSLCFLACIVVLTLFILW
                     RLWRFNHIIEYKNRMLAKLINEKFANKKDGNQLLEVYEEQEVSSELEPELISPEEQDEL
                     LDETDKESGEEEENKKIFQELNHTVVQKQLYLSPELSREDLAQIVHLNNARFARMIREC
                     TGTNFNGYINGLRINYAIKLMKKYPNYTIRAIADESGFNSAPILYNLFKKKTGMTPYEF
                     KKAQDTLRN"
ORIGIN
        1 atcttattat atatttgcag caaaatgaaa aactacagaa tctctaaata atgaaaatat
       61 ctttttccaa acaaactaaa gaacggactt tcaaacaact ttatgaggaa tattacgccc
      121 cattttgtct gtatgcaaaa aggtttgttg atgataaaga gacacgtgaa gacatcgttt
      181 cggatgtatt cacctcatta tgggataaac tggatactga ttcttttgat cttcaatcga
      241 acaccgcatt agcttacatc aaaatgtgcg taaaaaatag ctgcctgaat ttcctgaaac
      301 accaggaata tgaatggagc tatgcggaaa atatacagaa gaaagctcct gtctatgaaa
      361 cagaaccgga tagtatatat actcttgatg agctatacag aatgttgtat gagacattaa
      421 acaaacttcc cgaaaactat cgaacggtct ttattaaaag tttctttgaa ggcaaaacgc
      481 atacagagat tgcaaaagag atgaatctta gcgtgaagtc tatcaatcga tataaacaaa
      541 aaacgatgga acttttacgt aatgaattga aggagtatat gccactatta ctcttgttat
      601 ttcttcgtgc ataatctaca ccctcatgtt ctcttcctga tatatgcctt tcttttgaaa
      661 aacagttgtg cattatatgt attagtcctg tgttgtttat atcactctgc ttaatagtta
      721 gcaggggctt actagtgtgg acaaataagc tatctgttgt gaacaaatct gtttacggtt
      781 gtaaacagat ttgttcacat gggtgagccc ttgtaaaaca ttagagctta acaaaagaac
      841 aactaaatat caatgtatga catatagggg aatatagtat atattagttg ggagcaggac
      901 gagacagggt gagggtgtga gggtaaaacg tcatcaacat ttgtttggct aagatgcgac
      961 actctgcccg gtttattttt ccgttctctg tttgcggaat ggattctatt gtcaatatat
     1021 gcttgggacg ataataaggt tccagtattt catgtagttt atttccgatt tcttctgtgt
     1081 cgggctgatc tgccaataat aaagtgacag cctgccctaa gcgctgatcc ggaactgaag
     1141 taatgacaaa ggacacagga ataaacgggc ggagcaactt ctccatctcc tctgcttgaa
     1201 tcttaattcc tccactgtta atcacattgt ctttccggcc tagaatcata aaacttccat
     1261 cgggatagat acgtgcaatg tcattggtct gcaatgtttc gtcacatacc aaaggggcat
     1321 caatgattaa tgtattctct gcggataaag acaatttcac tgaaggaaat ggataataat
     1381 gttctgaagc cgatgctccg ttcagacgac gaagggcaat atgcgacaaa gtttcagtca
     1441 tgccataagt ggagtaaacg gcagtcggaa gatggtttat ctccgtttcc agagcctcat
     1501 caacggctcc gcctcctata atcagaatat ccgtttgttt taatcgctct ttttcttcgg
     1561 gaacctgcat cgtgttataa acttgcaatg ggaccattgc cacaaatctc aaaggttctt
     1621 ttatatccgc caacggatga ccggaagcag gacgaacaat cagattcaaa cctgcaacca
     1681 atgaacgtac gaccaccatc attgcaccga tataacgaag attcatacat aataatgccg
     1741 actcaccttt cttcaaattc agaaattcac aagtcagacg tgcactttgc atcatttgat
     1801 ccttgcgtac catcagttct ttaggtatac ccgtggagcc cgatgtatga actgtaataa
     1861 caggagaatc attaaaccat tcgttcagga aaagatataa atcccaataa gcaggagaat
     1921 gagcttctgc tcctcctgct atcagttggc ttatttcttc aaaagtgtat tcttttcctt
     1981 ccagtagcaa gcgctgttgt tgtcgatcga atatcatcag aatatccttt aaataccact
     2041 aaataccatc atttacaaaa ccacaggcaa tcttttctga tttcaagagg cacttctata
     2101 ttgtcagtaa agagcatacc cgttcccaat ccttgtggta acggattatt gaatgttgca
     2161 caccaatggg cgatagcatt caaaccaatg ttggactcca aagcggaagt gatccaccag
     2221 ccgatatgtt gcttttccgc ttccataatc cattcatccc ctccacatat tcctccgtgg
     2281 agagatggtt taatgatgat atattgcgga cggatggttg ccagcagttt ctttttttct
     2341 tccagcgtgt tgcatcctat cagctcttca tccaatgcta ctggcaacgg agattcagaa
     2401 gtgagccgag ccatttcttc ccattgtccg gcacgaatcg gctgttcgat agaatgtaaa
     2461 tcaaattctg acagacgttt cagtttttcc attgcatcac ccggagagaa agcaccgttt
     2521 gcatctacac gcaactctat ttctttagaa gagaaatggg tacgaatatg acgtagtaat
     2581 gccaattctt tttcaaagtc gatagcgcca atctttagtt tgacgcaacg gaatccggct
     2641 tccatctttt tctcgatctg ggataacatg ttttcaaaat ctcccatcca gatcaggccg
     2701 ttgattggaa tccctacctc tccacgtgaa aaagccgtat cggacaaagc ccaactccct
     2761 gcaaagaaat gccagatagc cgtttccaag ccaaataaga tggaaggata cttgcataga
     2821 ccatctttat ccaattttcc ctgttcttcc tctacttgcc ggcaagttct tattaatata
     2881 tcttcgtaat cagggagatc atcacaactt aacgcaggca aaggcgcaca ttctccaatt
     2941 cccactctac ccggaaaatc aggagaagta aagtgaagat accagacttt tcgtgtagta
     3001 tatgttcccc gggaagttcc cgcgggttgc ttgaaatgaa gcaaccgagg aataatatct
     3061 atcttacaat ccataatgaa tatcttttca atctgctaat tactgcacaa tcagtctttc
     3121 attagcctat tattttaagg gaatttcgga tattgtttga agttcggttt acgtttctcc
     3181 aggaacgcat tctttccttc ctgtgcttca tccgtcaggt aataaagtaa tgttgcgtca
     3241 cctgccaact cctgaatacc tgcctggccg tccagttcgg cattcaatcc cgctttaatc
     3301 atgcgcaaag ccaatggact aagcaacatc atttcttccg cccattgcac gtattcatct
     3361 tccagctgtt ccaaaggtac taccttattc accaatccca tatccaatgc ttcttgtgca
     3421 ttatacttac ggcaaaggaa ccaaatttca cgtgctttct tctgtcctac cacacgcgcc
     3481 agataagatg caccgaatcc ggcatcaaaa ctacccacgc gaggacctgt ctgaccgaaa
     3541 atggcatttt ccgaagcaat ggataaatca catactacat ggagcacgtg acggccacca
     3601 atggcaaagc cgttcacggc agcaatcata ggtttcgtaa tactacggat ttgcttttgt
     3661 acatccaata cgctcaaacg aggcacaccg tctttcccga tatatccgcc acgtcctttc
     3721 acattctggt cgcctcccga acagaacgcc ttatcaccgg ctccggtaat tacaatcaca
     3781 tcaatatccg cttcttcacg gcaaatgcgc aatgcatcac tcatttcggc agtggtagtc
     3841 ggggtaaatg cattccgata acgttcacgg ttgattgtga tacgggcaat tccattataa
     3901 taatcaaaaa gaatatcgtc gtattctctg atggttgtcc actctctttg tgttggcata
     3961 atttatttct gttttaattg atgataataa ttcttcaaca tacgtgcatc cttgtttttg
     4021 ttggtaaaca cttccaggag cacaggttgt tccatagttt ccggctgggt gaaagttttc
     4081 attgcttcag tcagctcttc atcattttgt gcctgcagat aaaggaaacc acgttcctcc
     4141 gcccagcctt tggctgacgt tttatgaact gctgcaataa atttatgtga ggtgcccgac
     4201 atatccaatc ccggtaaagt atggaaaatc tctcctcctc cgttatttaa taaaaggata
     4261 cgcaggttgg aacggacgtt gatattccat aacgcattca tatcatagaa gaaacttaga
     4321 tctccgatag ctatgaaatt cagtttgtcg gaagctgccg cataaccgac agcggtagac
     4381 aacgatcctt caataccact tgttccccga ttgcagcaaa cttcaattgc agaaggaatc
     4441 gaatatagtt gtgcataacg aactaccgaa ctgtttgcca gatgcaatgc acaggactcc
     4501 ggcaaagctt tcaataatgt accgacagcc aacatctccg aataggcaaa atccggttcg
     4561 ggaataatct tacaataatt ctcccataca cggggatagt caggagtccg gttatccagc
     4621 aggctggcga tcttctccag aaattcaaac gggtccatct cgatcactgt agtcaatgag
     4681 ccgtacaaat cgaccacctc accctccggc gatacgtgcc aatgctcttt aggcggatgc
     4741 tgacggagaa acttcttcaa tcgtttggaa acgacatgtc ctccgtaagt aatcagcaat
     4801 tcgggaacca tctggtctat cttctcttcg ggcatggcat aaagtgccgc atcgaaattc
     4861 tttaccggaa taccgggaac tgtctgattg ccgatatgtt ccgtcaacca ggcaaaatgt
     4921 ttatataata acttgatata tcttttttca aacagataaa taaggttcat ctgaccgatg
     4981 ataatcatgc gcttctgata tttattcatc cggtcgacca gatcattata atcacggtca
     5041 tagacgttca atccctgata acgggttatc acacgtactt ccgggagtgc atctaccgtg
     5101 aattgaaaca gcggttcgga aataggaaca ttgatatgca ccgggccttt tccatgatga
     5161 ttcgtctcca gcaaggcttc attcaccagg cgattacaat accattcatc ttcttccgta
     5221 tgaatctccg gaagattgac cgacttcttt accagcgttt gaaacacacc cggttgcggc
     5281 actgtctgtc catccatctg tccgatccag gcagcgggac ggtctgctga aatgacaact
     5341 aaaggaacat tctgataaaa tgcttcggct acagccggat gaagatttaa taatgcagta
     5401 ccggaagtgc agcacacagc agcaggctta ccaccattca acgcaagacc aatggcaaaa
     5461 taaccggcac tccgttcatc cgtcactgca taacaggtga agttcggatg attagacaaa
     5521 gtatgtacga tgggcgtatt acgactaccc ggacacaaca caaccttagt aatcccgtgc
     5581 gcctcgagca acgcaaccaa ctggagtatg ttcttcttgt ctgtatacat gatgataatt
     5641 attagtagtt tatgatttta aaggaggcgt tgcaataagc cgtttgatgg tttgcaactt
     5701 cttttccgtt tccagccatt cgtcattcaa ttccgaagaa gccagtagtc caccgccggc
     5761 ataaagagtc agttgttcat cttcaatatg catgcagcgc agattcacat agatgtcagt
     5821 tcgcccttcc gggtccagcc agccgataaa gccggaataa tagcggcggt cgtagccttc
     5881 gttctgcaat ataaaccgat aggcttcttc tttcggtaaa ccgcatacag caggcgttgg
     5941 atgcaacact ttcaagagat ctcccaaacc tttgttatct ttcaaagaaa accggaaatc
     6001 tgttttcaaa tgtgacaaag cacctgcata agccggataa ggcccgttct ccgtagaatg
     6061 aatgcccaac gataggagtt ggcgacgaat ataagaagcg acataatcct gctctttccg
     6121 gttcttttca tcccacactt gcggcagtct gccatcttgt aaaggctgcg ttccggctaa
     6181 cgcaaccgta tgccattcgt ctttttcacc tgataaaatg atttcaggag tgcttcccag
     6241 ccagataccc gtctgcggag tgtagcacaa gtatatatat gaatgaatat aacgcctgca
     6301 cgctgcacga aatatagaca aaggagaaaa accggatact ttatcaatag taagatgacg
     6361 tgaaagtact aatttatcaa aagtattatc acgcaaagca tttataaagg tatgaaagca
     6421 ggaggcatat tcctccgtag aagaagtcag gaacgattct tgtccttgca tccgcaaagc
     6481 gacttcccgt tcttctgccg tatcattgtc aatcggcaaa ggttgccccc actgatcggg
     6541 ttgaatcaat acgacaggac acgtctcact cacctgaaac ggagcgatga caaatcctct
     6601 ctgtccattc agttctttca ggtcgtatat cagacgtacc gctccttccg cctgtgtcaa
     6661 cagacgggga actttctccc cgggaatacg gtaaacagca aacggctgct tccgctgaat
     6721 aaatgcatca atagttgtca aattacttat ttcttcgtcg gtcatctctt tttcatcaca
     6781 ctgttgacta cccgtatgga agacactagt ttgtttgttg aagtaaacac gtctacattc
     6841 catacatggg aggaacgtcc cttatgtaca actgttccta ctgcacgcac tgtatctcct
     6901 tcatgtgcag aagatatgtg gtttccactg acctgcattc ctactacaat ctcgtccggc
     6961 tggcaaagaa tcattgaacc gagtccggca actgtttccg ccaatgcaag agtagccccg
     7021 ccatgcaaaa tgccaaaagg ctgacgggta cgatggtcta ccggcattgt tgcttccaca
     7081 cggtcttcgt cggcataggt atattgaatt cccaagtttc ccatcaatgc gtggcgtgcc
     7141 tgcgcattca gttggtcaag gggaatttcg gctgcacgca cttcggatat gatagccttc
     7201 tccactgcaa cggccactcc gtcttcctca ttcgaagcag tcacataatc ggcacaggct
     7261 ttcaccgagt cttgtgaatg tcccatagct atacccagcc ccgccaattg aatcattgtt
     7321 acgtcacaca caccgtcgcc cacagcaatc acttcctcac gcttcatacc tagcacctcc
     7381 agcaaagcac ccaaagaatt agctttgtcg atggcgcagg gaactacttc cagaaaatag
     7441 ggctccgaac ggaatacgtc caacgcccca ttcagtcgtc tcttccagtg atcttccaaa
     7501 ccaagcaatg cttcttcgtc atcgctcacc agcatacact tacaaggagc aaaatcaacg
     7561 gcagcagaaa attcttcttc tttgattatt tgcaggtcat tcaaccgggc ttcattttgg
     7621 atatgttcat tttcaggaga atccgttatg atcgtatcat catgataagt gaataaagca
     7681 aaaccgtttt tacgggcttt cttttccaga tacggcaaca tttcgggatt aatccgacgt
     7741 tcaaacagaa tttctccgtt ttgtgcattg ataatctgac agccattata ggaaaggata
     7801 aaacctccat agtttccaag ttcgagcatc ttagctagtg gcattaagcc ataagtcggt
     7861 ctgccggatg ccaatacgat acgtactccc atttgctgaa ccttcaacag ggcagccaat
     7921 gtacgtttac taatttcttt cgcatcattg aggagtgttc cgtctacatc aagaacaaat
     7981 aagttatact tcatgattac acgattttga tgtagattac aaaggtagga attggagtga
     8041 tctccagaag gcgtaaacag ataaaattac tttaatttca ctctctcaaa cgcatttcca
     8101 gataatcgcg aagaattcgg gcgtgattat acaccggttc ttttgaagca taaagtagtg
     8161 ttatcaccgg atgtggtttg ataagagtca gaaaatcagc cattgatgga gaagcatcca
     8221 gctctttttg atactgcgtg acaaaatctc cccaatgtcc gggaatatct tcatgaaacc
     8281 atttacgtaa tgtaggggat ggtgttatgt cttttgccca ataatcgtat ttcaaccatt
     8341 ctttcttcat tccgcgtggc cataatttat ctaccaacac ccggtatcca tctgtttctg
     8401 aaaaatcttc gtaaaccctc tttatcctta cctgtatcat ttccattaat atttagttat
     8461 caatagataa accgggaaaa acgaaaattg tttagtagaa ctatttaatt cctcaatgtg
     8521 tcctgcgctt ttttaaattc ataaggagtc attcccgtct ttttcttaaa aaggttatat
     8581 aatatcgggg cactattaaa tccggattca tcagcgatgg cacgtatggt atagttagga
     8641 tattttttca ttagcttgat cgcataatta atgcgcagtc cgttgatgta cccattgaaa
     8701 ttagttccgg tgcattctct tatcatccgg gcaaagcgtg cattattcag atgtacaatc
     8761 tgcgccaaat cttctcttga gagctctgga gaaagatata gctgtttttg aacgactgta
     8821 tgatttaatt cctggaatat tttcttgttc tcctcttctt ccccactttc tttgtctgtt
     8881 tcgtccaaaa gttcatcctg ttcttcagga gaaatcaatt ccggttccaa ttctgatgaa
     8941 acctcctgtt cctcgtacac ttccaataac tgattaccat cttttttatt ggcaaatttc
     9001 tcgtttatca gtttggcaag catcctgttt ttatactcga ttatatggtt gaaacgccac
     9061 aaacgccaaa gtataaacag ggtcagcact acaatacacg ccaaaaagca gagtgaaaca
     9121 ttccttattt ttagctgtga ggcttgctcg gcgatgtatt cttctttttc ggaagcaccg
     9181 tacatcgcgt tcaattctaa tgcagcattt ttcctgtcgg tactgttaat gctatccgtt
     9241 attgcaatga tggtttcacg tatttctgcg gcttctttat aacgattcag ccccagatat
     9301 gcctggactt ccttattaag tatagttaaa tattgagcgt tcaaggtatc ccgctgtgtt
     9361 ctcaacaatt ctttaaagtc cttacagttg tctattactg tctcatattg tttggaaaga
     9421 atcaaataag gaatcgaata catcttgcca tccggagtat gagattcttt tattgccaga
     9481 tatttttgat aatatccttc tgcttgcgca tatttctttt ctaaataaga aatataggcc
     9541 aattttgcat ataaatagct atattgacca tcaatgtagc cttcgggaac ctccggtact
     9601 ttctctaatt ttttaagaag tttttcacgt tcataagcaa gagccaaagc ttcatcaata
     9661 cgggaatctg tcattaaaaa tcccatctct gctccataat aataggaaag cagcatcatt
     9721 cctctcatat cctttgaccc acgcagtaat tcaatcgtac gaccaaaata attatacgcc
     9781 tcatctttca atgacagcct ccaattattc tctcctatgc aaaaaagcaa tctagcttcc
     9841 gcctctctgt ccttcagttt ttgagcctgc ataattccac taagagcata atgcatgctc
     9901 tcattatatt tactcattat ggatgaaagt tcagctaaat aaaccgtcat cttcaacatg
     9961 tgcttaggtt ctctttgaga gatggaatca agcaagtacg acttccttgc atacataaaa
    10021 gctagtttat tcatatacat attacgatat gacaaactgc gcaattcatt aatcagacgc
    10081 agagggaagg cttttctggt ttcggcctca tccaacaact gtaaagcacg tttggggttg
    10141 gaaatataaa tatctctgat atatttttct gtatacaaag agtcattatt tataatttta
    10201 tcagcccttg aaaattgatt gtgtacaaat agaagcacaa aaatacatac ccaaaaacgc
    10261 ataaaactct taatcgtgtt aaatcattaa ttatccaaag gtatgtattt tccaaaaaaa
    10321 g
//
