LOCUS       gnlProkkaBMBODDLG_547  14219 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BMBODDLG_547.
ACCESSION   gnlProkkaBMBODDLG_547
VERSION     gnlProkkaBMBODDLG_547
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 04:22:19
            Original ID  :: gnl|Prokka|BMBODDLG_547
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14219
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14219
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[11:6072]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12..6072
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..14219
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14219
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(12..1742)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (127-378). E-value:
                     2.1e-24. Score: 78.1. Matches aSDomain:
                     nrpspksdomains_ctg546_1_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 161.9; E-value:
                     4.2e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg546_1"
                     /sec_met_domain="APE_KS2 (E-value: 6.7e-125, bitscore:
                     406.8, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHHLTTYITHDTLISALGFSTQENLEAIRAYHSGITLQTDKRIA
                     DTPLLAATISQERLQQRAETAGISAYTRMEQLFILTINDLIRQSGQTLEDKTCGLILST
                     TKGNIDLLTRHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALVTGKRMI
                     ENGIYRKVIVAGGDLLSHFITSGFLSFRSLSSRPCRPYDSNRDGLNLGEACGAVLLSTE
                     KTPNSIILSGGAISNDANHISGPSRTGDGLFFAIRQAMQEAGTALQNISFVNAHGTATV
                     YNDEMESKALTLAHLEQVPTHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYET
                     PGVPMPIPVYATHQHIPMKHCIKTASGFGGCNAAIVLSLPEYAPFKDEDNTLPEIRCTR
                     EVRIENSSVFINNELIFHSEEPDFGIFIRDTYKKSGGNNMKFYKMDDLCKLGYVAAEYL
                     LKDKTFAPLEMGMLLANATSSLHTDIRHQQLIDQDGDRAASPAVFVYTLPNVVSGEICI
                     RHKIQGENTFFITKAYQPEKLERYARIVMQKGKLNYCIIGWCELLKNTYRAVFKLIEKQ
                     "
     aSDomain        complement(609..1361)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg546_1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.10E-24"
                     /label="ctg546_1_PKS_KS.1"
                     /locus_tag="ctg546_1"
                     /protein_end="378"
                     /protein_start="127"
                     /score="78.1"
                     /tool="antismash"
                     /translation="MAENIAGYFHAEERVHVISNACISGVSALVTGKRMIENGIYRKVI
                     VAGGDLLSHFITSGFLSFRSLSSRPCRPYDSNRDGLNLGEACGAVLLSTEKTPNSIILS
                     GGAISNDANHISGPSRTGDGLFFAIRQAMQEAGTALQNISFVNAHGTATVYNDEMESKA
                     LTLAHLEQVPTHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYETPGVPMPIPV
                     YATHQHIPMKHCIKTASGFGGCNAAIVLS"
     CDS             complement(1727..2170)
                     /locus_tag="ctg546_2"
                     /transl_table=11
                     /translation="MKRKTSPQQAALTDRTTIKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKRYGLDYMSIYREGYVVPIVDLSCQFKQSLSFGEEAIVETRYIHSDAAKILFEYTI
                     YRASDQNIVATGTTTQVFLNTNRELELVNPAFYIEWKKKWNII"
     CDS             complement(2167..2604)
                     /locus_tag="ctg546_3"
                     /transl_table=11
                     /translation="MNRKEIICRGDELFRLIPQRPPMVMIDRFYGIEENTSWSGLTVTP
                     DNLFCRDGVLQETGIIEHIAQSAAARVGYIYMLREEPVPLGFIGSVEKMKIFRLPSAGA
                     ELYTGITIVQEIFDITLITAEVKENDELLAECRMKIYLKKE"
     CDS             complement(2601..3671)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 112.1; E-value:
                     5.7e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg546_4"
                     /transl_table=11
                     /translation="MMHKRYTKEQLTAVEAQRLAQEIAFGPVVFQVSRLMLKFGIFQLL
                     ADKRKGYTLQEISVQTGLTRYAAQVLLEASLTIGTILLEEDRYVLAKAGWFLLNDKMAR
                     VNMEFNHDVNYQGLFYLEEALLNGQPEGLKVFGGWPTIYEGLSQLPEQVQKSWFGFDHF
                     YSDNSFSQALEIVFLHSPKRLLDIGGNTGRWATRCVQYNQEVEVTIVDLPQQLEMMRKQ
                     TAGVPGAERIHGHGANLLDRTVPFPSGFDAVWMSQFLDCFSEEEATSILSRVAQSASKD
                     SKVYIMETLWDRQPYETGSYCLTQISLYFTAMANGNSKMFHSDDLIRCIKNAGLEVEEI
                     HDNIGLGHSILQCRLK"
     CDS             complement(3668..4570)
                     /locus_tag="ctg546_5"
                     /transl_table=11
                     /translation="MPETWKGKTRGGTFGYMFFIYMIRCLGITAAYGFLSLVVLYFIPF
                     APKATASTWQYARNRLKYGRAKAAGLLLKNYYRLGQILIDKVAIGNGMADKYHFEFENY
                     QAFLNVLNGNTGVIMIGAHVGNWEIGAPFFDEYGKKINIVMFDAEHERIKEILEKNAST
                     RDYKIIPVNEDNLTHVFRITEALERKEYVCFQGDRYLNKEKLLSSPFMGKEAEFPMGPF
                     LLASKMRVPVVFYFAMREAKKTIVSISLLPRRWYIPKRSGPNKHYWSNIHKRWKKSSGS
                     IRNNGSITTRSGHKYKSGL"
     CDS             complement(4570..4821)
                     /NRPS_PKS="Domain: PP-binding (7-74). E-value: 5.9e-13.
                     Score: 41.1. Matches aSDomain:
                     nrpspksdomains_ctg546_6_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg546_6"
                     /sec_met_domain="PP-binding (E-value: 1.4e-13, bitscore:
                     41.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDM
                     VVLIDRNFGFTVTAKDFAGIKTFQDFYNLVISHIQKED"
     aSDomain        complement(4600..4800)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg546_6_PP-binding.1"
                     /evalue="5.90E-13"
                     /label="ctg546_6_PP-binding.1"
                     /locus_tag="ctg546_6"
                     /protein_end="74"
                     /protein_start="7"
                     /score="41.1"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDMVVLIDRN
                     FGFTVTAKDFAGIKTFQDFYNL"
     CDS             complement(4843..6072)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (78-405). E-value:
                     9.7e-50. Score: 161.5. Matches aSDomain:
                     nrpspksdomains_ctg546_7_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 307.8; E-value:
                     2.1e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg546_7"
                     /sec_met_domain="APE_KS1 (E-value: 3.8e-167, bitscore:
                     545.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGRNQEEVKESLFQGKSGIGIAPARKEMGYF
                     SALTGLVERPDLKKLLDRKKRHSLAERGEYAYMATLEAFRQARIEEKFLLENEVGILYG
                     NDSSAAPVIQAIDIIREKKNTALVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACA
                     SGSHAIGMAYLLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSAREDEPEKASRPFDK
                     NRDGLVPSGGGASLVLESYESAVKRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQM
                     AVKDAGIPLEEIAYINAHATSTPVGDLNEAKAIAEVFGSHHPYVTSTKSQTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASALLNIPSRRVETEFDTFLSNSFGFGGTNSS
                     LIIRKFKENN"
     aSDomain        complement(4858..5838)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg546_7_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.70E-50"
                     /label="ctg546_7_PKS_KS.1"
                     /locus_tag="ctg546_7"
                     /protein_end="405"
                     /protein_start="78"
                     /score="161.5"
                     /tool="antismash"
                     /translation="ATLEAFRQARIEEKFLLENEVGILYGNDSSAAPVIQAIDIIREKK
                     NTALVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYLLIKSGLQD
                     CILCGGAQEVNPYSVGSFDGLGAFSAREDEPEKASRPFDKNRDGLVPSGGGASLVLESY
                     ESAVKRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAVKDAGIPLEEIAYINAHA
                     TSTPVGDLNEAKAIAEVFGSHHPYVTSTKSQTGHEMWMAGASEVIYSTLMMNNGFIAPN
                     LNFEEPDEASALLNIPSRRVETEFDTFLSNSFGFGGTNSSLIIRKF"
     CDS             complement(6080..6808)
                     /NRPS_PKS="Domain: PKS_KR (3-170). E-value: 1.2e-18. Score:
                     59.5. Matches aSDomain: nrpspksdomains_ctg546_8_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     219.4; E-value: 8.7e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg546_8"
                     /sec_met_domain="adh_short (E-value: 2.5e-37, bitscore:
                     118.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAICLKLAEMGYHILINYQSNDTEAEATLQQ
                     IREQGSDGELMKFDVTDAAATHAALNGWMEQHPDTYIEVLVNNAGIRRDNLMLWMEQEE
                     WSRVLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGIIAA
                     TKALAQEVAKKHVTVNAIAPGFIRTDMTDGIDENEWKKHIPAGRFGEPGEVAALVGFLT
                     SGQASYITGEVISINGGLYT"
     aSDomain        complement(6299..6799)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg546_8_PKS_KR.1"
                     /evalue="1.20E-18"
                     /label="ctg546_8_PKS_KR.1"
                     /locus_tag="ctg546_8"
                     /protein_end="170"
                     /protein_start="3"
                     /score="59.5"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAICLKLAEMGYHILINYQSNDTEAEATLQQIRE
                     QGSDGELMKFDVTDAAATHAALNGWMEQHPDTYIEVLVNNAGIRRDNLMLWMEQEEWSR
                     VLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGIIAATKA
                     LAQE"
     CDS_motif       complement(6734..6796)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg546_8_0001"
                     /evalue="2.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg546_8"
                     /protein_end="25"
                     /protein_start="4"
                     /score="20.2"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAICLKLAEMG"
     CDS             complement(6805..7197)
                     /locus_tag="ctg546_9"
                     /transl_table=11
                     /translation="MGVLGLNYGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDI
                     VSMGTNSALMAKTVIENAYQVMAILMMGIVQAIDCLDIADRISPRSQQVYKEIRAFFPV
                     FREDTPKYKEIESMMVYLKKGRFQEK"
     CDS             complement(7179..8375)
                     /locus_tag="ctg546_10"
                     /transl_table=11
                     /translation="MQKLYKTAYHTNPMLVENTITLASLYKILFEEEPLTLSDPCMQKL
                     EESFNFLKTFSNDKIIYGINTGFGPMAQYRIEDESLSQLQYNIIRSHATGAGQPLPERY
                     VKAAMVARLYTFLQGKSGVHKELALLITEFINRGIIPYVPEHGSVGASGDLVQLAHIAL
                     TLIGEGEVFYQGKKRDTASVLAENGLQPFQMHIREGLSVTNGTSVMTGIGIVNLIYARQ
                     LMQWAVGASVMMNEIAASYDDFMSEPLNGAKQHEGQQEIARMMRQWVKGSLCVRKRENE
                     LYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAEKVLINEINSACDNPIVDPDT
                     QNVYHGGNFHGDYVSFEMDKLKIAVTKLTMLAERQINYLFHDRINGIPPPLSIWEYWD"
     CDS             complement(8565..10046)
                     /locus_tag="ctg546_11"
                     /transl_table=11
                     /translation="MENKLTIYNTLSRQKELFVPLHAPHVGMYVCGPTVYGDAHLGHAR
                     PAITFDILFRYLTHLGYKVRYVRNITDVGHLEHDADEGEDKIAKKARLEQLEPMEVVQY
                     YLNRYHKAMEALNVLPPSIEPHASGHIIEQIELVEEILKNGYAYESEGSVYFDVAKYNK
                     DHHYGKLSGRNLDDVLNTTRELDGQSEKRNPADFALWKCAQPEHIMRWPSPWSNGFPGW
                     HCECTAMGKKYLGEHFDIHGGGMDLIFPHHECEIAQSVASQGDDMVHYWMHNNMITING
                     QKMGKSYGNFINLDEFFHGTHKLLTQAYSPMTIRFFILQAHYRSTVDFSNEALQAAEKG
                     LERLTEAVKGLERITPSAQTTGIEGVKDLREKCYTAMNDDLNSPIVIAHLFDGARMINT
                     VLDKKATLSAEDLEELKSVFHLFMYEILGIKEEAANNEAREEAYGKVVDMLLEQRMKAK
                     ANKDWATSDKIRDELAALGFEVKDTKDGFTWRLNK"
     CDS             complement(10437..12320)
                     /locus_tag="ctg546_12"
                     /transl_table=11
                     /translation="MKKLLSLWMFLPIFLVLAACSDNSEDIDRYYATVSTPKVTTTTPT
                     SLTVTASVTGDLNQIVKKGFCYSTATSTPTIKDHVVNADENFSATLSTLTTGTSYYIRA
                     YVYCDSRYVYSEVITATTESLSLDDELKNYVAPTYADDYTSISDWSKRSQWNLANVHDP
                     SVVLAEDGYYYMYQTDASYGNAHTAGGHFHSRRSKDLVNWEYLGGTMKNLPEWVVPKLN
                     EIRKEMGLAEVNPNINDFGYWAPVVRKVKNGLYRMYYSIVCPGTLNGANTWSERAFIGL
                     MENNDPANNNGWVDKGYVITNASDKGLNFNIKPNDWANCYYKWNAIDPSYIITPEGERW
                     LVYGSWHSGIAALKLNGETGKPAETLGQPWATGQAPAEYGQLIATRQTGNRWQASEGPE
                     IIYRDGYYYLFLAYDALDVPYNTRVVRSKSITGPYVGIDGKDVTAGADALPIVTHPYKF
                     SKGYGWVGIAHCAIFDDGKDNWFYVSQGRMPKDVPGINAGNAIMMGHLRSIRWTKNGWP
                     LVMPERYGAVPKVAITEEELPGNWEHIDLTYKYGEQRTSATMTLAADHTITEGTWKGSM
                     WSYDAGQQILTVNGVELYLQRETDWEANPRTHTIVYAGYANNKTYWGKKSK"
     CDS             complement(12400..14178)
                     /locus_tag="ctg546_13"
                     /transl_table=11
                     /translation="MRILRKLVYVCCSITLGLMALSSCEGGELYDVNAPDWISEKVDSI
                     ADSKKEPEEEVLEGMQEDVYSFGNTDYTSGFWTAFSKYYVVPDGQKWHGVFNLNINPAD
                     NTYYKNFALVITNDTDRGGEGYTEYGAYRFDTTNDTLAYNSQWGSHLFFKYTSSTLMLS
                     PVDNLDETVQKLGGKVTLTVDRTSENAFSIKIQNASATKTYKQPYKLPNLNIDKSNTNI
                     RCFLVPEGSYINFLQSNIIPIGGLTSAEDKNPLSMVLQNVPDQVNAGTSLEEAVVGITA
                     VVSFEEGVTKTVTAEELQFTAIPNMEELGTKTLVAIYNKTFKGENCNLPVVANATFEVV
                     EKIVSIQVTAQPTHTQYYYYTSAATEAMTDRTLAFLPEGLKVTATYADGSTQIIDNTKL
                     SFSAIVAKAGTQTVTITADEATATVAVKVAESTVSTVSNSADILGTEDNTTEWWTVFSD
                     NFNVPTGETKSISFTNYTSLANNWSNFAVVLRKADLAEYAVVRADNYGWGAGYDGNASL
                     VHNGTQGDWATWLADMNGAKVTVYVTNCGNGTTDIQAVMEGTSGTSYAQYYLGINKVDM
                     NDLNFALTIEGGHLVF"
ORIGIN
        1 ttccatattt tttattgttt ttcaatcagt ttaaatactg ctctataggt gtttttcaat
       61 aattcacacc atccgatgat acaatagttc agtttccctt tttgcatgac tatacgtgcg
      121 tatctttcca gtttctccgg ctgataggct ttagttatga aaaaggtgtt ttccccttgt
      181 atcttgtggc ggatgcaaat ctcgccggac actacattgg gtagtgtgta aacaaataca
      241 gccggactgg ctgcccggtc tccgtcctgg tctatcagtt gctggtgtct gatatccgta
      301 tgtagggatg aagtggcgtt ggcaagtaac atccccattt ccagtggggc gaatgtcttg
      361 tctttcagta agtattcggc ggcaacatat cccagtttgc aaaggtcatc cattttatag
      421 aatttcatat tgtttccgcc tgatttttta taggtatcac gtataaatat gccgaaatcc
      481 ggttcttcag aatgaaaaat aagttcgttg tttatgaaga cagaactgtt ttcaatacga
      541 acctcccgtg tacatcggat ttcgggcaag gtgttgtcct catccttgaa cggagcatat
      601 tccggtaaag ataagacaat ggctgcgtta cacccaccaa atcccgaagc ggtttttata
      661 caatgtttca tcggaatgtg ttggtgagtc gcatagaccg gtataggcat aggcacaccc
      721 ggtgtttcgt aacccggagt gccgaacagg atgccttgtt tcagttcgtg catacagaca
      781 atgctttcaa tgattcccga tgctcccaag gtatgcccga aatagggttt taagctatgt
      841 gtgggaactt gttccagatg agccagcgtg agggctttgg attccatttc gtcattgtat
      901 acggtggccg tgccatgggc attgacaaag ctgatgtttt ggagggctgt tcctgcctcc
      961 tgcatggctt ggcggatagc gaaaaagagt ccgtctcctg tacgggaagg gccggagata
     1021 tggttggcgt cattacttat ggctcctccg gaaagaatga tgctgtttgg cgtcttttcc
     1081 gtacttagta atacggctcc gcaagcttct cccaagttca gtccgtcacg gttgctgtca
     1141 tacggacggc atggacggga gctgagggac cggaaagaca ggaaaccact ggtgatgaaa
     1201 tgagagagaa ggtcacctcc cgctacaatt actttgcggt agatgccgtt ctctatcatg
     1261 cgttttcctg ttacaagggc tgacactcct gatatgcagg cgttggagat gacatgtacc
     1321 cgttcctcag catggaaata accggcaatg ttttctgcca ttttccaaag aaagaccgct
     1381 tcatcgggat gttccgtatg acgggtcagt aagtcgatgt tcccttttgt ggtagagagg
     1441 atgagtccgc aggttttatc ctccaaagtt tgtccggact gacggatgag gtcgttgatg
     1501 gtcaatataa acagttgttc catccgggta tatgcgctta ttcctgctgt ttctgcccgt
     1561 tgttgcaatc tctcttgcga gatagtagct gccaataggg gagtgtctgc aatccgtttg
     1621 tccgtctgca gggtgatgcc actgtggtag gcccggatgg cttccaaatt ttcctgtgtg
     1681 ctgaaaccca gcgcgctgat cagggtatca tgggtgatat aggtagtcag atgatgttcc
     1741 atttcttttt ccactctatg taaaaggcag gattaaccaa ttccagttct ctatttgtat
     1801 tcaggaatac ctgtgtagtg gttcctgttg ccacaatgtt ttggtctgat gcccggtaga
     1861 tggtgtattc aaaaaggatt ttggcagcat cactatgaat ataccgtgtc tcgacaatgg
     1921 cttcctcacc gaatgacagc gactgtttga actggcagct caggtctacg ataggaacta
     1981 catagccttc ccggtagatg ctcatatagt ccaagccata tcgctttccg aaagcttcac
     2041 gtccatcttc gaaataacgc acatattcac catgccatac tatctgcatg gaatctattt
     2101 cactgaagcg gaccttgatg gtggtccggt ctgtcagtgc tgcctgctgt ggacttgttt
     2161 ttcgtttcat tcttttttca gatatatttt catccggcat tcggccagaa gttcatcgtt
     2221 ttctttcacc tcggcggtaa tcagtgtgat atcgaatatt tcctgcacaa tggttattcc
     2281 ggtatataat tctgctccgg cagaaggaag acggaatatt ttcatttttt ctacagagcc
     2341 gataaagcct agtggtacag gctcttctcg cagcatatag atatatccta cccgtgccgc
     2401 tgctgattgg gcgatgtgtt ctatgattcc tgtttcctgt aatacgccgt cccggcagaa
     2461 cagattatcg ggggtgacgg tcagccctga ccaggatgta ttttcttcta tcccatagaa
     2521 acggtctatc atgaccatgg gcggacgttg tggaatcagc cggaacagtt cgtctccccg
     2581 acaaatgatt tcttttctgt tcatttcagt ctgcattgca ggatactgtg tcccagtcct
     2641 atgttatcat gaatctcttc cacttccagt ccggcatttt taatacagcg gatcaggtca
     2701 tccgaatgga acatcttgct gttgccgttg gccatggctg tgaagtaaag gctgatttga
     2761 gtcaggcagt aagagcccgt ttcgtatggc tgccggtccc acagcgtttc catgatgtag
     2821 actttactgt ctttgctggc ggactgtgcc acacgactta ggatactggt tgcttcctct
     2881 tccgaaaagc agtccagaaa ctggctcatc catacggcgt caaagcctga aggaaagggc
     2941 acggtccgat ccagcagatt ggcgccgtgg ccatggatgc gttctgcacc gggcacaccg
     3001 gcagtttgtt ttctcatcat ttccagttgt tgaggcaaat ccacaatggt tacttctact
     3061 tcttgattat attggacgca tcgggttgcc catctgccgg tgtttccacc aatatcgagc
     3121 agtcgtttcg gtgagtgaag aaatacaatt tctaatgcct ggctgaacga gttgtccgag
     3181 tagaaatggt caaagccaaa ccagcttttc tgtacctgtt ccggcagttg ggaaagtcct
     3241 tcgtaaatgg taggccatcc gccgaatact ttcaatcctt ccggctgacc atttaaaaga
     3301 gcctcttcca gatagaaaag tccttgatag ttcacatcgt gattgaattc catattgaca
     3361 cgtgccattt tatcattcag cagaaaccag cctgccttgg ccagtacata gcggtcttct
     3421 tccaacagga tggttccgat ggtcagcgat gcttccagta atacttgtgc tgcatagcgt
     3481 gtcagtccgg tctgcacact gatttcttgc agcgtgtatc ctttccgttt gtcggccagc
     3541 aattggaata ttccgaattt caacatcaga cgtgaaactt ggaataccac gggaccgaaa
     3601 gcgatctctt gcgccagtct ttgtgcctct acagctgtca attgctcttt tgtatatctt
     3661 ttatgcatca taatccagat ttgtatttat gcccagaacg ggtagtaatt gaaccattgt
     3721 tccggatact gccggacgat tttttccagc gtttgtgtat attgctccaa taatgcttgt
     3781 tcggcccgct tctctttggt atgtaccacc gcctcggcaa taaagaaatg gaaacgatag
     3841 tttttttcgc ttcacgcatg gcaaaataga atacgacagg tactctcatt ttggaagcca
     3901 gcaggaaagg acccatcgga aattcggctt cttttcccat gaacggactg ctgagtaatt
     3961 tctctttatt cagatagcga tcaccttgaa agcagacata ttctttgcgc tccagtgcct
     4021 ctgtaatacg gaatacatgg gtcagattgt cttcatttac gggaattatt ttataatcgc
     4081 gtgtggaggc attcttttcc agaatctctt ttatccgttc gtgttcggca tcaaacatga
     4141 caatattgat ttttttgccg tattcatcga agaaaggagc acctatttcc caattaccta
     4201 catgggcacc tatcataatt acgccggtgt ttccattcag tacgttcaaa aatgcctgat
     4261 agttctcgaa ctcgaaatga tatttgtctg ccatcccatt gccgatggct actttgtcaa
     4321 tcaatatctg ccccagccgg tagtaatttt tcaataacag tccggcggct ttggcacgtc
     4381 cgtatttcag tctgttccgt gcgtattgcc aggtactggc ggtagctttc ggtgcgaaag
     4441 gtataaaata gaggacgacc aatgacagaa agccgtaagc cgcagtgata cccagacagc
     4501 gaatcatgta gatgaagaac atgtatccga atgtacctcc tcttgtttta cctttccatg
     4561 tttcgggcat cagtcttctt tttgtatgtg cgaaattacc agattataga aatcctggaa
     4621 ggttttgata ccggcaaagt ctttggctgt cacggtgaaa ccgaaattcc tgtcaatcag
     4681 tactaccata tctaccaaat caaggctatc caattccaag gtttgcatca aaggggcgtc
     4741 cggctgaatc aattctacat caatctcaaa ttcttcggcc agggtggttc tgatcttttc
     4801 gatgatttct tcgttggtca taaatttata tattggttta aattaattgt tttctttgaa
     4861 tttgcggata atcagtgagg aattggttcc tccgaatccg aatgagttgg acaagaatgt
     4921 gtcaaattcc gtttctaccc ttcgggaagg gatattcagc agggcagagg cttcatcggg
     4981 ctcctcaaaa ttgaggttgg gtgcgatgaa gccgttgttc atcatcaaag tggagtaaat
     5041 gacttcactg gctcctgcca tccacatctc atgtccggtc tgtgatttgg tggatgtgac
     5101 gtagggatga tggctcccga atacttccgc tatggctttt gcctcgttca aatcacctac
     5161 aggagtggat gtggcatgtg cattgatgta tgcaatctct tccaaaggaa tacccgcatc
     5221 cttgactgcc atctgcaaag agcgtctggg gccatccaca ttgggtacgg aaatgtgatc
     5281 tccgttggat gaaaagccgt atcctatgac ttctgccagg atagtcgctc cgcgctttac
     5341 ggctgactca taactttcca gcaccagact ggcgcctccg ccgctaggta ctagtccgtc
     5401 acggttttta tcgaatgggc gggatgcttt ttccggttcg tcttcccggg cggagaaggc
     5461 tcccaacccg tcgaaactac ccacggaata agggtttact tcctgtgctc ctccgcacag
     5521 aatgcagtcc tgaagtcctg atttgataag cagataagcc ataccgatgg cgtgtgaacc
     5581 actggcacag gctcccgata tagtgaagtt aattcctttt agatggaaaa taaccgaaag
     5641 attcatggta atggtggaat tcatggactg gaaaatagaa ccggaaccaa ccaatgccgt
     5701 attctttttc tcgcggataa tatctattgc ttgaataacc ggagcagcac tactgtcatt
     5761 gccatacagt attccgactt cgttctccaa caggaacttt tcttctatcc gggcttgccg
     5821 gaatgcttcc agggtagcca tataggcgta ttctccccgc tcggcaaggc tatggcgttt
     5881 cttgcggtcc aataatttct tcaaatcggg acgttcgaca agaccggtta acgccgagaa
     5941 atagcccatt tctttgcgag ccggagcgat tccgatgcct gactttcctt gaaacagtga
     6001 ctctttcact tcctcttgat tcctgcctat gcacgaatag atgcccattc ctgtaataac
     6061 tactcttttc atcttttgct tacgtatata atcctccatt gatggaaatc acttctccgg
     6121 taatgtagga agcttgcccg gatgtcagga agcctaccag tgcggctact tccccgggct
     6181 cgccgaagcg tcctgccggg atgtgttttt tccactcgtt ctcatcaatt ccgtctgtca
     6241 tatctgtacg gataaatccc ggtgctatgg catttaccgt cacgtgtttt ttggcaactt
     6301 cctgcgccaa cgctttggta gcggctatga ttccaccttt ggctgccgaa tagttggtct
     6361 gccccggcat ccctttgatg cccgacaggg aaacgatatt gataatacgt ccgaaccgct
     6421 ttaccagcat attcttcagc aagggttggg tgacgttaaa gaaaccgttc aggctgatat
     6481 ccagtacccg gctccattct tcctgttcca tccacagcat caggttgtca cggcgtatac
     6541 cggcattgtt caccagtacc tcaatgtaag tatcgggatg ctgttccatc catccgttca
     6601 gtgcggcgtg tgtggctgct gcatctgtca cgtcaaattt catcagttcg ccatccgagc
     6661 cttgttcccg tatttgttgc agggtggctt cagcttccgt atcgttgctt tggtagttta
     6721 tcagtatatg atatcccatt tcggccagtt tcagacaaat ggctcgtccg attccccggc
     6781 ttcctcctgt tactaatgcg tatttcattt ttcttgaaac ctcccttttt taaggtatac
     6841 catcatgctt tctatctctt tatatttagg tgtatcttcc cggaaaacag ggaaaaatgc
     6901 tcgtatttct ttatatactt gttgtgaccg ggggcttatc cggtcggcta tatccagaca
     6961 atcaatggct tgtacaatac ccatcatcag gatagccatc acctgataag cattttcaat
     7021 gactgttttt gccatcaagg cggaattggt acccatgctt acaatgtcct ggttgtcatt
     7081 gttgttgggg atgctatgca catacatcgg attagacaaa gtctggcact ccgccgtggt
     7141 agaagtcgcg gtaaattgtg atgcttgcaa gccatagttc aatcccagta ctcccatatt
     7201 gacaaagggg ggggaatgcc gttgatgcgg tcgtgaaaca ggtaattaat ctgccgttcg
     7261 gcaagcatcg tcagtttggt gactgctatt ttcaacttgt ccatttcaaa agatacataa
     7321 tctccgtgga agttaccacc atgatataca ttctgtgtgt cagggtccac tatcgggttg
     7381 tcacaagctg aatttatttc gtttatcaat actttttcag cattgagtaa ttcatcataa
     7441 accggcccta gaatttgtgg aatgcaacgt agcgaataat agggctgcac tttatgggtg
     7501 aagatcttct cttcgtgctt cccattataa agttcattct ctcttttgcg tacacacagg
     7561 ctgcctttta cccattggcg catcatgcgg gctatctctt gttgtccttc atgctgtttg
     7621 gccccgttca gcggttcaga catgaagtca tcgtatgagg cggctatttc attcatcata
     7681 acagatgcac ctaccgccca ctgcataagt tggcgtgcgt aaatcagatt gacaatacct
     7741 atacctgtca tgactgaagt gccgttggtc actgaaagcc cttcgcggat gtgcatttga
     7801 aaaggttgca atccgttttc cgccagcaca gaggccgtat ctcttttctt gccttggtaa
     7861 aagacttctc cttctccaat cagagtgagg gcgatatggg cgagttgtac cagatcacca
     7921 ctggccccca cactgccgtg ttcgggtacg tatggaataa tcccccgatt gataaactcg
     7981 gtaatgagca acgccagttc tttatgtacg ccggatttgc cttgcagaaa agtatagaga
     8041 cgcgctacca tggcggcttt gacatagcgt tccggaagag gttgcccggc tccggtggca
     8101 tggctgcgga tgatgttgta ttgtaattgc gataaggatt catcttcaat acgatattgg
     8161 gccatggggc caaagccggt attgatgcca tagatgattt tgtcgttaga gaatgttttc
     8221 aggaaattga aactctcttc cagtttttgc atacatgggt cggagagtgt cagtggctct
     8281 tcttcaaaca aaatcttata tagggacgct aaagttattg tattctcaac tagcattgga
     8341 ttggtgtgat aagcagtttt gtatagtttc tgcaaaaata gttatttaaa aataagtatt
     8401 accatccgaa gggagatttt tcagttttga tggttatctg aaaggttcac cacagattat
     8461 acaaataaac gcagatgctt cttaaatcat tgattgttag gttggataat ctgtgtgaat
     8521 ctgtatagtc tgtggtgaaa aaatatagta ccgctctacg tattctattt attcagtctc
     8581 catgtgaaac catctttggt atctttcact tcaaagccaa gagcggctag ctcatcacgg
     8641 attttatcac ttgtagccca gtctttattg gctttggctt tcatacgttg ttccagcagc
     8701 atatctacta ctttgccata tgcctcttca cgtgcctcgt tattggcggc ttcttctttt
     8761 atacccaaga tttcatacat aaagagatgg aacacacttt tcagctcttc cagatcttcg
     8821 gcggaaaggg tcgctttttt atcaagcact gtgttgatca tacgggcgcc gtcaaacaga
     8881 tgggcgatga caatcggtga gttcaggtca tcgttcatgg ctgtatagca tttttcacgt
     8941 aagtctttta cgccttctat gccggtggtt tgtgcgcttg gggtgatgcg ttcaagacct
     9001 tttacagctt ctgtcagccg ttccaatcct ttttcggctg cttgtaatgc ttcgttactg
     9061 aagtccactg tactgcggta atgtgcctga aggatgaaga aacggatggt catggggctg
     9121 taggcttgtg tcagtaactt gtgagtaccg tgaaagaact catccaagtt aataaagttg
     9181 ccgtatgatt ttcccatctt ctgcccatta atggtaatca tgttgttgtg catccaatag
     9241 tgaaccatgt cgtctccttg tgaagccacg ctttgtgcga tctcacattc gtggtgtggg
     9301 aaaattaagt ccattccccc tccatgaata tcgaaatgct cgcccaaata ttttttgccc
     9361 attgcagtac attcacaatg ccaaccggga aaaccgttac tccacgggct tggccagcgc
     9421 atgatatgtt cgggttgtgc acatttccac agagcgaaat cggcaggatt acgcttctcg
     9481 ctttgaccgt ccagttcgcg ggtggtgttc agcacatcgt ccaggttacg gccggacagt
     9541 ttgccgtaat gatggtcttt gttgtatttt gctacatcga aataaacgga accttcactt
     9601 tcataagcat agccgttttt cagaatttct tctaccagct ctatctgttc aatgatatga
     9661 cctgatgcat gtggctcgat actgggtgga agtacattca aggcttccat tgccttgtgg
     9721 tagcgattga ggtaatattg tactacttcc atgggttcca attgttccaa acgggccttt
     9781 ttggcgattt tatcttcacc ttcgtctgca tcgtgttcca gatgaccgac atcggtaatg
     9841 ttacggacat aacgtacctt gtatcccaga tgggtaagat aacggaacag gatatcgaac
     9901 gtgatggcgg gacgtgcgtg tcctaaatgg gcgtcgccat atacggtagg accgcataca
     9961 tacataccta catgaggggc atgcaaggga acgaaaagtt ccttttgacg gcttaatgta
    10021 ttgtaaatgg ttagtttatt ttccataatt cattctatta gaattgcaaa gttataaatt
    10081 aaagtgtgta tttggctaat aattaacaaa aaatctgatg ctggtgtcct ctgcttgtct
    10141 acaaatgatg tttgttggtt taaggaatag agatttatgg tgataaataa aagtaagaat
    10201 taggataaaa ggttgtcttt gaacgtaaaa gaacaaaata atgatttttt gtatggagat
    10261 tagggaacct aactcttttt ccttttcatg aaataggttt ctcttgtatc tgtttaatga
    10321 tctttaattt ctgctattga cttgtaaaac aggaccactg ccccataaac attggtgttg
    10381 ttttgagggg cagtggtcct gtttctatat gaagtttgcg tgcgggagcg ggaatgttat
    10441 ttggatttct ttccccaata cgtcttgttg ttggcatagc cggcatagac gatggtatgg
    10501 gtacgtggat tggcttccca atcggtttca cgttgcagat aaagttccac tccgttaaca
    10561 gtcagaatct gttggccggc gtcatagctc cacatactgc ctttccaggt accttcggtg
    10621 atagtgtggt cggcggcgag ggtcattgtt gctgaagttc tctgctctcc atatttgtat
    10681 gtaaggtcga tgtgttccca attgccgggc aattcttctt cggtgatggc tactttggga
    10741 acggctccgt aacgttcggg cattacgaga ggccaaccgt ttttcgtcca gcggatgctg
    10801 cgtagatgtc ccatcatgat ggcgttaccg gcgttgatgc ccggaacatc cttaggcatg
    10861 cgaccttgtg agacgtagaa ccagttgtct ttgccatcat cgaagatagc acagtgggcg
    10921 atgcctaccc agccgtaacc tttgctgaat ttatagggat gggtcactat gggcagtgca
    10981 tcggcaccgg cggtcacgtc tttgccgtca atgcctacgt agggaccagt gatgctcttc
    11041 gaacggacta cacgggtgtt gtagggcacg tcaagggcgt cgtaggccag gaagaggtag
    11101 tagtagccat cacggtaaat aatttctgga ccttcactgg cttgccagcg gttacctgtc
    11161 tggcgggtgg cgattaactg accatactca gcaggtgctt ggcctgtagc ccaaggctgg
    11221 cccaaagttt cggcaggctt gcctgtctcg ccattgagtt tgagagcagc tatgccgcta
    11281 tgccatgaac cgtagaccaa ccagcgttcg ccttcgggcg tgatgatgta agaggggtcg
    11341 atggcattcc atttgtagta gcaattggcc cagtcatttg gctttatgtt gaagttaagt
    11401 cctttgtcag aagcattggt gatgacgtag cctttgtcca cccagccgtt gttgttggcg
    11461 gggtcgttgt tttccatcag gccgatgaag gcgcgctccg accaggtgtt ggcaccgttg
    11521 agtgtgccag ggcagacgat ggaatagtac atgcgataga ggccgttctt taccttgcgt
    11581 actacgggag cccaatagcc gaagtcatta atattagggt taacttcggc aagtcccatt
    11641 tctttgcgta tttcattgag cttaggtact acccattcgg gcaggttctt cattgtaccg
    11701 ccgaggtatt cccagttgac aaggtctttg gaacgacgac tgtggaagtg cccgcctgcc
    11761 gtgtgggcgt ttccatagga agcatctgtc tgatacatgt aataataacc atcttcggcc
    11821 aataccaccg aggggtcgtg tacgttggca agattccatt gagagcgttt gctccagtca
    11881 cttatcgagg tatagtcatc ggcgtaggtg ggggccacat aattcttgag ttcatcgtct
    11941 aagcttaagc tttctgtggt ggccgtgatc acctcagaat agacatagcg gctgtcacag
    12001 tagacgtatg cacggatata gtaagaggta ccggtggtca aggttgagag ggtggcgctg
    12061 aaattctcat cggcattcac cacatggtct ttgatagtcg gtgtggaagt tgctgtactg
    12121 taacagaagc ctttcttgac tatttggttc agatcacccg taaccgacgc ggtgacggtc
    12181 aatgaggtgg gtgtggttgt agttactttc ggagtactta cagttgcata atagcggtct
    12241 atatcttcgc tgttgtcaga acaagcggct aaaacaagga atattggtaa gaacatccac
    12301 agggataata gttttttcat ctgttgatag tttaaaggcc atgccgcttc ttctggttcc
    12361 tgaggaaaac ggcatggttt gtgtgattac tgattcggct tagaagacga gatgtccgcc
    12421 ttcaatcgtt aaagcgaagt tcaagtcgtt catatctact ttgttgatcc ctaaatagta
    12481 ttgggcatag gaggtacctg aagtgccttc cattaccgcc tgaatgtcgg ttgtaccatt
    12541 gccgcaattg gtcacgtaga cggtgacttt ggctccgttc atatcggcaa gccaagtagc
    12601 ccagtcgcct tgtgtaccgt tgtgaacgag gctggcattt ccatcgtatc ctgcacccca
    12661 tccatagttg tcggcgcgta ccactgcata ttcggcaaga tcggctttgc ggagaacgac
    12721 agcgaagttg ctccagttat tagccaggct ggtgtaattg gtgaagctga tggacttagt
    12781 ttcaccggtc ggcacgttga aattgtcgga aaagacagtc caccactccg ttgtattgtc
    12841 ttcggttccc agaatgtctg cagagttgct gacagtggaa actgttgatt cggccacttt
    12901 aactgctacg gtagcggtag cttcatcggc agtaatggtt acggtctgtg taccggcttt
    12961 ggcgacaatg gcagagaaac tgagttttgt gttgtcaata atttgggtgc ttccgtcggc
    13021 ataagtagcc gttactttca atccttccgg aaggaatgcc agcgtacgat ccgtcatcgc
    13081 ttcggttgca gccgaagtat aatagtaata ttgtgtatgt gtaggttgag ccgtcacttg
    13141 gatggataca atcttttcca ctacttcaaa cgtagcattg gctaccaccg gcaagttgca
    13201 attctcaccc ttgaaggtct tgttatagat ggctaccagt gtcttcgtac ccagttcttc
    13261 catattgggg atggcggtga actggagttc ttcggcggtt acggtcttag tcaccccttc
    13321 ttcgaagctg acgacggcag taataccgac cacggcttct tcgagtgaag tgccggcatt
    13381 gacctgatcg ggtacatttt gcagtaccat cgagagcgga ttcttgtcct cggcagaagt
    13441 aaggccaccg ataggaatga tgtttgattg taagaagttg atataagagc cttcaggtac
    13501 taggaaacag cggatgttgg tattgctctt gtctatattc agattgggta acttgtacgg
    13561 ctgtttgtag gttttggttg ccgaggcgtt ctggattttg atagagaagg cattttcact
    13621 ggttcggtct acggtgagtg tcactttgcc gcccaatttc tgtacagttt cgtccagatt
    13681 atcaacgggt gacagcatca gcgtgctgga ggtgtacttg aagaagagat gggaacccca
    13741 ttgggagtta taggccaaag tatcgtttgt agtgtcaaaa cgataagcac catattccgt
    13801 atatccttct cctccacggt ctgtatcgtt ggtaatgacg agggcgaagt ttttataata
    13861 ggtattgtcg gcgggattga tgttgagatt gaacacccca tgccatttct gcccgtcggg
    13921 cacgacgtaa tacttggaga aagctgtcca gaaaccggag gtgtagtctg tgttaccgaa
    13981 ggagtagaca tcttcctgca taccttccag tacttcttct tccggctctt tctttgaatc
    14041 tgctatagag tccactttct cggagatcca gtcaggggcg tttacatcat ataactcgcc
    14101 accctcgcag cttgacaatg ccatcaaccc caaggtgatg gaacagcaaa cgtatactaa
    14161 ttttctgagt attctcattg tcttaaattt taataggttt ttttatttgc ttaagtcga
//
