LOCUS       gnlProkkaOHFECELD_178  11015 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OHFECELD_178.
ACCESSION   gnlProkkaOHFECELD_178
VERSION     gnlProkkaOHFECELD_178
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 08:33:59
            Original ID  :: gnl|Prokka|OHFECELD_178
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11015
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11015
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1701:6015]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1702..6015
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11015
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11015
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             2..475
                     /locus_tag="ctg82_1"
                     /transl_table=11
                     /translation="MLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDVV
                     FIPKNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTK
                     VKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     CDS             490..1638
                     /locus_tag="ctg82_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1702..2421
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg82_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2442..3743
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg82_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.1e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3760..4884
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg82_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.2e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4894..6015
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg82_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg82_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.7e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4984..5991
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg82_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg82_6_Aminotran_5.1"
                     /locus_tag="ctg82_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6012..6485
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg82_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6482..7927
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg82_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7927..8649
                     /locus_tag="ctg82_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8663..9676
                     /locus_tag="ctg82_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9681..10640
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg82_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 gcaattgggt gaagccatga ttgactcttt gggtattggt gttgaggata cctttacggt
       61 aggcattgat ctggagaagg ctttgactaa tcctaagggt agtgccgacc ttgtcctacg
      121 tgaaggtgat gtggtcttta tacctaagaa tactaatact gtaactatca atggtgctgt
      181 tatggtcccc aatacggttt cttatatgaa gggaaaggat gtggattatt acctgaatca
      241 ggccggtggc tattctgata atgcaaggaa gagtaagaag ttcattgttt acatgaatgg
      301 tcaggtgacg aaggttaagg gtagtggtaa gaaacagatt gagccggggt gtgagattat
      361 tgtgcctggt aaggctaaga agaaagggaa catagctaat attttaggtt atgctacttc
      421 cttcagttct ttgggtatga tgattgcttc tattgctaat cttataaaga aataatagaa
      481 tttactttta tgtcagaaca acgacaggat aaaaacttgc tctctgaacc acacaagaca
      541 gaaagtgatg agatagaaat tgatttggtc gatatctttc gcaagattat tgctattcgt
      601 aaaaaattat acaaagccgt tggaattggt tttattattg gaataattgt agcggtaagt
      661 atccctaaac agtatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaagggg
      721 agtaatggtt tagccggact tgctgcctcg tttttaggag atggggctct aataggggaa
      781 agcacagatg ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta
      841 ttggaacttt tagaaatgga agtctccgtt tctaaaaagg atgataaaat gactttgggg
      901 tcttatctcg atgaagagtc atctccttgg tgggattatc ttataggttt tccgggcata
      961 gtaataggag gagttaaatc attattcgga gaagatacgg ttcctgccag tggagggcgg
     1021 caaggaacta tcgaattgac gaaagaagta aatgagaaga ttaattttct taaaaagaag
     1081 attagtgcat ccattgataa gaaaaccgcc ataacgagca ttacggtcac cttacaaaat
     1141 ccgcagatca ctgcggttat agcagattct gtcgttcata aattacagga atatattatt
     1201 gggtatcgaa cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa
     1261 cgtcagcagg aatattatgc tgctcaaaga aaatatgcgg attatgtaga cgcccatgat
     1321 aatgtggttc ttcaaagtgt acgtgctgag caggagcgtt tacagaacga catgagtttg
     1381 gcttatcaga tatatagtca ggttgctaat cagttgcagg tatccagagc caaagtacag
     1441 gaggaaaagc cagtctttgc agtagttgag cctgccgttg tacctttgaa accttcaggt
     1501 atgggactca aaatttatat tttattattt gtgttcctgt ccgtatctgg tactctcgtg
     1561 tgggtgcttt ttggcaaaag tctgctggct agcttgagaa aagaactgaa aaataaggag
     1621 atagaacagg ataaatgatg ctaaaacgtc gtttacaaca ttcttatatc aattaaattc
     1681 acttactata ttattaaacg aatgatacgt acagctatga taatggctgc gggcatggga
     1741 acccgttttg gccaatatac agaattgata cctaaagggt tcgtcaaagt gggaggtatt
     1801 ccaatgatag ttcgttctat tgatactttg ttatcatgtg gcattgagcg aattgtaatc
     1861 ggtacaggat ataaacaaga agtttatgaa gaattgaaga cagactatcc tatgcttgaa
     1921 acctgtttta gtcctcgtta tgctgaaaca aatagtatgt atactttata taatacgcgg
     1981 gagattctgg gcaatgatga ttttttattg ttagagtcag atttgatttt tgagaaacaa
     2041 gcaataatga gcttattgga gtgtcctgcg gcagatgcaa tgctaatagc tccagtgaca
     2101 aagtttcaag atcagtatta tgtggaacat gatgataatt ttcgcctttc ttcatgttct
     2161 gtcaataaga ataaactaaa cgctaaaggc gaattggtcg gcatccataa actatccggt
     2221 tccttttaca aaataatgtg tgctgattat gcgagtattg ttgatgaaca acccaatttg
     2281 ggatatgagt atgaattact acgaatatct tgttctcaat ctcctgttta tgtgcataaa
     2341 gtagaagggc tgaaatggta tgaaatcgat gacatatcag atttggaata tgcagagaaa
     2401 tatattgttc cgtattgtta attaaaataa tatatcaaat tatgagtaag acagtttata
     2461 ttgggatgac tgcggatatt atgcatccag gacttatccg cattattaat gaggctacta
     2521 aatacggtga tgttataatt ggtcttctta cagataaagc tattgcggag cataaacgcc
     2581 ttccttatct gacctatgaa caacgaaaag aggtagttca gaatattaaa ggcgtatgta
     2641 aagttgttcc tcaagaagaa tggagctatg ttgagaatct caaacgcatt aaacctgact
     2701 atataattca tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat
     2761 ttgaagtgat gaatgaacag ggaggaaagg ttatcgaaat tccatatact ttgggaatta
     2821 attcatcttc tttggataaa gatattaagg ctataggtac aacccccgat gtacgtttaa
     2881 aatcacttcg tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg
     2941 gactatgtgg cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat
     3001 ttgacggaat gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg
     3061 aggcggttga tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta
     3121 aacctattat ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac
     3181 gcactttaga acgtcatgga atctcagcta taataattga agataaagtt ggattaaaaa
     3241 agaattcatt gtttggtacg gatgttattc aaactcaaga tacaatcgaa ggtttctgta
     3301 ataagatcaa agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta
     3361 ttgagagcct tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg
     3421 tccaagcggg agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa
     3481 aagaattttg tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta
     3541 ctacatatga tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt
     3601 atgctaatca tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagacaatat
     3661 tagagaatga acgtgcttta gaggtgcgcg aactgtgtat gcccataaag gaaatattgg
     3721 aactgattcc gggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt
     3781 tatgaaacgt ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta
     3841 aaaaatattt gtgcctatat cacagaccat acttcacgtg agaaacatat catagctgct
     3901 aatgaaggtg cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct
     3961 gtggtttata tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca
     4021 gatgaacaag tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga
     4081 acaaaagatg aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca
     4141 atgcggattc cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat
     4201 gatatcatac aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat
     4261 gtttttggca aatataaact tcaaaaagag ttcggatgta attatccttt atctcgtgag
     4321 gatgctttgc aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact
     4381 ggcaagcttt ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat
     4441 gattttctca cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata
     4501 gcaaagcaag atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta
     4561 ggggcaatta gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac
     4621 aatggtgctc acgagtctgt aggaggacag cctactttag gatttagttt agatattccg
     4681 gctattgtcc gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt
     4741 gaagaagcaa tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt
     4801 aaaatagatt ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag
     4861 cattttatgg attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta
     4921 aatcctgggc ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt
     4981 tgtcctcgcg agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga
     5041 gttgctcatg ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc
     5101 aatattgata tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat
     5161 aatggggcat atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt
     5221 aatttggaat tttccgttta cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa
     5281 gaaaatcctg atatagctat ggtttatact actcatcacg agacgggtac aggaattctg
     5341 aaccctattc gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat
     5401 actacttctt ctttgggcat gattcctttt gatatagaga aagataatgt ggatttttgt
     5461 atggcatctg ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat
     5521 gaggaacaga ttaagttttc aaaaaaatat cccaagcgtt cttactattg taatctttat
     5581 ttgcagtatg agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact
     5641 atttacgcca ctcgtcaggc attaaatgaa tattttgaag tgggcgaaga agctaagttt
     5701 gcccgtcaca aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa
     5761 agtgtaataa agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat
     5821 cccaactggg attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat
     5881 ccaggtaaga tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta
     5941 gatgatattg agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca
     6001 ttaccgatgt catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc
     6061 gtggtataca cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct
     6121 tagtaggcaa atatagcaat atctacttag gtaaaaatgc tgaaatacgt tcaggctgtt
     6181 atctgattgc tcgtgataaa atcattattg gagaaaactc aacactcgcc tatggaacga
     6241 ctatattgac aactgctgat cctaatggac cgtataatgc attagcagtt ctttatcctt
     6301 ataaaaaggc accggtagtt ataggagata atgtttggat tggggctaat gttaccatcc
     6361 ttcctggagt aactattggt gattacgttg tagtagcagc tggagctgtt gtaacaaaag
     6421 atgtaccttc aggagtattg gtagctggtg taccagctat tgtgaaaaaa cgttttaata
     6481 aatgaaagaa aaaacttctt taaagaacaa agccatatgt ggaatctttt ggagtgcagt
     6541 tgaacgattt ttatcacagg ggatacagtt tgtagttaca gtcattatgg cgcgttttct
     6601 attgccatct gattatggaa tggtaggaat gttagcaata gttcttcaat tatctcaaac
     6661 gttaatggat agtggtttta ctaatgccct tattcgttat aaggaacgta ctgaaattga
     6721 ttattcaaca gttttctttt ttaatatatt agcatcatta gttatttatt ttctaatttt
     6781 ttttctagct ccttatatat cgtggtttta taaaataggt caattagttg agattactag
     6841 aattttatct attgttattg ttttaaattc ctttgcgatt attcctaaaa ctaaattaat
     6901 aatagctgta gattttaaaa ctcaatcaaa agtctcattt attgcagctt tggtttcagg
     6961 tattattggc atttgggctg catatttaga ttttggagtt tgggctttag ttggacaaac
     7021 tttagtaaac ggattgttga ttgtagtttt gtatgcatat ttttgtagat ggaaaccatt
     7081 gtggatattt tcattgaaat cgtttcgttt attatttgct tttgggtcaa aattagtatt
     7141 agctaatatt cttaatactt tatataaaaa tctgtatgct atagttatag gaaagaagtt
     7201 ttcgtcggtt gatttaggat tttatactcg tgcggaacaa tttgctcagt ttccttcata
     7261 taatttgagt gcaataattt ctagagtgac ataccccata ttgagccttg tgcaaaatga
     7321 taatgataga ttatctgctt tatataggaa atatgtccgt ttatcttctg cttttatctt
     7381 tccattgatg attttgttaa ttgtcatagc tcagccactg gtattattgc ttttgacaga
     7441 aaaatggata ggagtagttg tattgcttca aatattgtgt ttagattgga tgtttgatca
     7501 tttgagtagt ataaatttga atttactata tgtaaaggga cgttcagact tggctttacg
     7561 tttagaagtt ataaaaaaag tgttagcgac ggggatcctt cttctatcta ttccttgggg
     7621 gattgtaggt atgtgttggg ggcgtgttat gtattcattg attgctgtgt atttgaatac
     7681 ttattataca gaatcattga ttaaattaag tcttattaga cagatgagag atatactacc
     7741 aagctttttt ttagcattaa taatgggagg aggtacttgg tatatgattt tattgttaga
     7801 gggtgaaatt gttcaaattg tagtaggaag tgttattgct ttattgctat atggaacgtt
     7861 gttgtattgc ttttctcgat ccttgtttga tgaaatatgg gcggttatat taaaaataaa
     7921 aaggtaatgg ataaactgag tttgattatt agtaaaatac gacggaatca ttggtataga
     7981 acctatatgc gtcctatata tttatttgtt tatggcaata gaaaattgaa gaatagaaat
     8041 agaatatttt tgcagtattc acaagagctg ctaactaact ttcatcaagc aatgaatgaa
     8101 gtgggaattc cttattggtt agaatttgga actcttttag gtgctgttag agaacacagt
     8161 tttataagtc atgattttga tcttgatgtg ggccttttta aggaagatta ttcagatata
     8221 ataagagagg tcttaaaaaa atatggtttc aaaagaataa ggtgtataac cgcccttgat
     8281 tttattgatg cttatgagga aacttatctt tataaaggtg tgacaattga tcttttcctt
     8341 ttttcaagag agaaaaattg tgatggggtc tattgttatg attttgttcc agtatattca
     8401 gatataaaga gaactaaaaa aggtgataat gcaatccgga gaattcattt tcctagaatt
     8461 gatttgattg aatattcatt tattggaatt aatacttttg ttcctgaaaa ttatgaggaa
     8521 catctttgta tgcattatgg taaagactat atgattccaa atcctcattg gaaagattca
     8581 gatgcgcaac atactgatat cttttatggt agagagatta gaattgaatt gtttgataaa
     8641 agtaaataat agtagataat acatgttcta tctatttttt ttactaattg tgctattttt
     8701 gttatatata caaagtagga aaagacaata ttctactgta gcgggaattt gtgttcctat
     8761 tattataatt tttgttgtaa tttgtcgtta tagagtgggg tatgactatt taacgtatta
     8821 tacattaatt gaaaatgaag aagaggcaca gattttatac ttattttctc ctttaagcat
     8881 tgtttgggca gagattgctt tatattttga atctccacag atgttatttg ttctttttgg
     8941 gcttccaaca tttgctcttc taatatttac tttaaaaaaa tattcaaaag attatgcgtt
     9001 atcagtaact attttaattt gtttcttctt ttttacatca ctcagtatta ttcgacaagc
     9061 tttggctttg gctatttgtt tttatggtta tcgttttata gtaaaacgtt cactaattaa
     9121 atatatatta tgtatattga ttgcagcttt attccatcct tctgcaggag tagcgattat
     9181 tatatattgg ttgccatttc taaagtttag attagttgta ttattatcta taatatcaat
     9241 agtagccaaa cctttatttt tttatatgct aaatatatta ggggtgtata cctcttatct
     9301 tgatggcaag atggatattg aaggtgggaa atatactcaa ttaatatact ttttgttgtt
     9361 tattatttgt tttgttttgg gaagtaaaaa catagataaa aacaagtgta atttatttaa
     9421 tgttttattg ttaagttttg ttttcgtatc ttttttagga gctcatttag gcgggagaat
     9481 agcgttttat tttaatatat attattgttt gttgattcct aaagtggtta aaggattgga
     9541 tgggcaacta agagagcaag tgaagcttct ttcttatttt ctatgtattt cttatttctt
     9601 attgtaccta ttcgttccat tcataaaagg tgtaccctca tattatatcc catataagtt
     9661 tatatttttc aaatagtaaa atgttgatat ctataattgt cccttgttat aattctgaaa
     9721 gatatttgtc tgattgttta ttgtctatat tgaatcaaac ctatgttaat tgggaggtga
     9781 tttgtataga tgatggaagt caagataata cattatctat tttaaatcat tacgctacat
     9841 tggatgagcg ttttaaaatt atttctcagt ctaatgcagg agtgtctgtc gcaagaaata
     9901 aggctctatc ccagtgtcaa ggagagtata tttgctttgt tgatagtgat gacctgatag
     9961 aacctaattt tttgataaca cttttacagc ttataagtca tcaggctgat ttggcaatct
    10021 gtggttttac tcgttctatg gttttctgta tggatgatgc tcaaggatat atagaaatga
    10081 gtggtaaacg ttgtatagaa agaattattc tagataaaag tttcaatcct cagatttgtt
    10141 gtatgttatt tcgacataat attataaaag agaaacaatt agaatttgtg atagggtgta
    10201 ctcgtggtga agatcgtgaa tttatattga aatatttagt ttattctaat aaggtttgtt
    10261 atacaaacaa tcttctttat cactatcgtg taaatgatca gtcagccatg gcaatctttt
    10321 ctattaaaag tttgacaagt atagaagctt cacaacgcac ggtcaactac tataaaaaag
    10381 tgaattattc tgttagaggg cttgaatttg aattttcacg tacattgtgg aaattcatga
    10441 ttttagctat tttgtctggg caaaatgatt tatatcaaat cattcgagaa aagtatgatc
    10501 taaaaagaca aatggaacat ctttattctc atccaggact atccgaaaaa cttacagcga
    10561 gattgtttgt ttggaatgag gcacttttta aatgggtatt ttctattatt agatatctat
    10621 ataaaaaaag atggagatga ataaacgaaa tagattatct gaacaagaaa taaaaaaagt
    10681 agaacttgac gctttattgt atattcggaa aatttgtcag caatatcatc ttcgctatta
    10741 tttagcttgg ggtactttgt tgggagccgt taggcataaa ggatttattc cttgggatga
    10801 tgatattgat ataatgatgc cacgttcaga ttatgagcga ttattggagt tagttccttc
    10861 cttgagacat agttattata aaatcttaag taatccaaag aatgaggatt attattatac
    10921 tcatgcaaaa atgatagata ctcgtacttt gtgtgtggaa aatgatttgc aaactattca
    10981 aaatatgggg atttgggttg atattttccc cttag
//
